1. Disruption of neurexin 1 associated with autism spectrum disorder
- Author
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Hyung-Goo Kim, Kishikawa, Shotaro, Higgins, Anne W., Ihn-Sik Seong, Donovan, Diana J., Yiping Shen, Lally, Eric, Weiss, Lauren A., Najm, Juliane, Kutsche, Kerstin, Descartes, Maria, Holt, Lynn, Braddock, Stephen, Troxell, Robin, Kaplan, Lee, Volkmar, Fred, Klin, Ami, Tsatsanis, Katherine, Harris, David J., Noens, Ilse, Pauls, David L., Daly, Mark J., MacDonald, Marcy E., Morton, Cynthia C., Quade, Bradley J., and Gusella, James F.
- Subjects
Autism -- Genetic aspects ,Chromosome abnormalities -- Health aspects ,Genetic disorders -- Research ,Biological sciences - Abstract
Two independent subjects that display an autism spectrum disorder (ASD) in association with a balanced chromosomal abnormality involving 2p16.3 are studied to implicate the neurexin 1 (NRXN1) gene. It is suggested that subtle changes in NRXN1 contribute to susceptibility to ASD.
- Published
- 2008