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Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome.
- Source :
-
American Journal of Human Genetics . Apr2002, Vol. 70 Issue 4, p896. 9p. - Publication Year :
- 2002
-
Abstract
- A genome scan of the hoarding phenotype (a component of obsessive-compulsive disorder) was conducted on 77 sib pairs collected by the Tourette Syndrome Association International Consortium for Genetics (TSAICG). All sib pairs were concordant for a diagnosis of Gilles de la Tourette syndrome (GTS). However, the analyses reported here were conducted for hoarding as both a dichotomous trait and a quantitative trait. Not all sib pairs in the sample were concordant for hoarding. Standard linkage analyses were performed using GENEHUNTER and Haseman-Elston methods. In addition, novel analyses with a recursive-partitioning technique were employed. Significant allele sharing was observed for both the dichotomous and the quantitative hoarding phenotypes for markers at 4q34-35 ( ), by use of GENEHUNTER, and at 5q35.2-35.3 ( ) and 17q25 P p .0007 P p .000002 ( ), by use of the revisited Haseman-Elston method. The 4q site is in proximity to D4S1625, which P p .00002 was identified by the TSAICG as a region linked to the GTS phenotype. The recursive-partitioning technique examined multiple markers simultaneously. Results suggest joint effects of specific loci on 5q and 4q, with an overall P value of .000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of .0001 for genomewide scans. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETICS
*PHENOTYPES
*TOURETTE syndrome
Subjects
Details
- Language :
- English
- ISSN :
- 00029297
- Volume :
- 70
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 6417448
- Full Text :
- https://doi.org/10.1086/339520