1. Socioeconomic Inequalities and Molecular Risk for Aging in Young Adulthood.
- Author
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Potente, Cecilia, Chumbley, Justin, Xu, Wenjia, Levitt, Brandt, Cole, Steven W, Ravi, Sudharshan, Bodelet, Julien Stephane, Gaydosh, Lauren, Harris, Kathleen Mullan, and Shanahan, Michael J
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PSYCHOLOGICAL aspects of aging , *MATHEMATICAL models , *METABOLISM , *GENE expression , *HEALTH insurance reimbursement , *SOCIAL classes , *MESSENGER RNA , *GENE expression profiling , *HEALTH insurance , *THEORY , *RESEARCH funding , *BODY mass index , *SMOKING , *PSYCHOLOGICAL stress - Abstract
Diverse manifestations of biological aging often reflect disparities in socioeconomic status (SES). In this paper, we examine associations between indicators of SES and an mRNA-based aging signature during young adulthood, before clinical indications of aging are common. We use data from wave V (2016–2018) of the National Longitudinal Study of Adolescent to Adult Health, a nationally representative study of adults aged 33–43 years, with transcriptomic data from a subset of 2,491 participants. Biological aging is measured using 1) a composite transcriptomic aging signature previously identified by Peters et al.'s out-of-sample meta-analysis (Nat Commun. 2015;6:8570) and 2) 9 subsets that represent functional pathways of coexpressed genes. SES refers to income, education, occupation, subjective social status, and a composite measure combining these 4 dimensions. We examine hypothesized mechanisms through which SES could affect aging: body mass index, smoking, health insurance status, difficulty paying bills, and psychosocial stress. We find that SES—especially the composite measure and income—is associated with transcriptomic aging and immune, mitochondrial, ribosomal, lysosomal, and proteomal pathways. Counterfactual mediational models suggest that the mediators partially account for these associations. The results thus reveal that numerous biological pathways associated with aging are already linked to SES in young adulthood. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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