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Cholesterol metabolism plays an important role in pathogenesis of Alzheimer’s disease (AD). Curcumin has been reported to decrease cholesterol in serum through increasing the cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) expression, but the underlying mechanisms are not fully understand yet. To investigate the effects of curcumin on the activity of calcineurin and the expression of ABCA1 in vitro, N2a/APP695swe cells were treated with curcumin at 5 umol/L for 24 h, or with the calcineurin activity inhabitor CyclosporinA (CsA) at 0.5 umol/L for 48 h. Our findings showed that curcumin could increase the expression of the ABCA1 at mRNA and protein levels, furthermore, it could inhibit the calcineurin activity, CsA also could increase the expression of the ABCA1 at mRNA and protein levels. These findings suggest that curcumin may upregulate the expression of ABCA1 via inhibiting the calcineurin activity in N2a/APP695swe cells.

Because of the complex geologic space body and the underground seepage conditions, it is difficult to predict groundwater water inflow in prevention and treatment control work of coal mine. To predict the groundwater flow of the coal seam under the roof sandstone aquifer in Nanshan coal, the big water well method and three-dimensional numerical model were used at the same time. The quantity of predicted normal water inflow was 553.5 m3/h by using numerical model and the big-well method is about 591.6 m3/h. The result of big-well methods was relatively close to the result of numerical simulation method, which proved the rationality of the two methods in parameters selection and model building, and greatly improved the reliability and accuracy of prediction results. Compared with large-well method, by establishing the complex 3D geological structure of underground water and fitting the parameters based on the actual data of hydrology, numerical method could simulate the process of groundwater seepage and dewatering engineering, overcome the parameter uncertainty of large-well method, improve the predictive accuracy of the mine water inflow, and has important application value.

UHF electromagnetic waves radiated by PD in GIS can range from several hundreds of MHz to several GHz. FDTD method is usually used to simulate the characteristics of the UHF electromagnetic waves. Compared with the traditional ideal Gaussian pulses in simulation, one equivalent PD mathematical model based on the actual measure PD sources was considered to simulate the propagation characteristics. Time domain and frequency domain spectrum of signals excited by the two PD sources were studied to analyze the propagation characteristics. It can draw the conclusions that each insulator detect leads to each electromagnetic and its time domain and frequency domain spectrum. So it is recommended to use equivalent PD mathematical model to simulator the propagation characteristics.

In order to realize single longitudinal mode (SLM) output, an erbium-doped fiber (EDF) laser with fiber ring cavity is proposed which uses an un-pumped EDF saturated absorber as a SLM selector. Ring cavity length, coupler ratio and insertion loss which affect ring cavity filter performance are analyzed theoretically and simulated numerically. Un-pumped EDF length and Er3+ concentration are analyzed theoretically and simulated. Research shows that, the bigger coupling output ratio of ring cavity, the greater transmission peak; the greater mode line width; the shorter ring cavity length, the wider free spectral range; the bigger coupling loss, the smaller transmission peak; when the difference between two cavities length is big, cursor effect is not obvious. Laser threshold increases with absorber length increasing; the bigger saturated absorber concentration, the higher laser threshold.

Thermal recovery technology are widely used to enhance heavy oil recovery, the four most important of which are thermal modification, sub-critical water modification, catalytic modification and catalytic modification with hydrogen donor. These four kinds of technologies previously were studied separately, which were not systematically integrated together. This paper used high-temperature and high-pressure reactor to simulate heavy oil’s thermal recovery in static condition. By studying basic properties and structural parameters changed of four kinds of thermal recovery technologies, we have drawn the conclusion that The quality of crude oil dropped only by the use of TM, and The degrees of improvement were as follows: CMH> CM> SWM . H/C (Atomic ratio), fA, fN, fPand CI were important parameters, which could explain the extent of condensation and condensation direction. Long chain sulfur compound break down into small molecules, damaging the colloidal structure of heavy oil, improving the quality of heavy irreversible.

With the road traffic congestion problems become more and more serious, and the current traffic lights don’t possess the function of revising timely and flexible, it can't meet the requirements of real-time controlling and make the traffic in intersection more efficient. The design of Microcontroller-based traffic signal controller fixes this problem. It based on STC90C51 as CPU solutions; LED lights and digital pipe were used as display module; 8 independent keyboards were used as the only manual input device; Software used the C programming language. The intelligent traffic light system covered the multi-phase and multi-period. So we could choose two-phase/four-phase/six-phase according to the particular road and traffic condition. Besides, it took the special status of emergency vehicles into account. It also had a manual input keyboard so that you could adjust the signal at any time. This design can effectively improve the traffic congestion problem.

The degree of difficulty of coal seam water infusion is the important basis of pouring water into coal beds, by fully analyzing influence factors of the degree of difficulty of pouring water into coal beds, the main influence factors of pouring water into coal beds was determined and the fuzzy clustering analysis model was build which base on the depth of burying of the coal seam, crack growth degree, porosity, moist edge, water saturation value-added and consistent coefficient. By comparing evaluation result of this model with Fisher evaluation result, the model result is accuracy and reliability. According to this model to predict South decurrent 18th layer 7th face Coal Seam of Shuangyashan Mining Group Dongrong No.2 Coal Mine,the predicted results are consistent with the actual situation and offering theoretical guidance to the choice of injection water parameters .

Steel structure system is the combination of specific fitting composites which are bamboo veneer and cold bending thin-wall steel, it is a high efficiency and energy-saving building structure system. It contains the advantages of both steel and bamboo, giving full play to the advantages of light weight, high strength, seismic.

This paper attempts to use PLAXIS 2D for calculation sheet pile wharf, mainly introduces this methods simulation process, parameter selection and so on. Using this method for a underground continuous wall structure to simulate, calculate and analysis. The results with the actual criterion calculating results come very close.

In this paper, the mineral properties of the lean magnetite in RongTian mine corporation was studied, during which the analysis of the mineral properties, prelimenary separation on the lump mine, two-section grinding, one section fine screening and three-section low intensity magnetic separation process were carried out. The results showed that if the suitable mineral processing flowsheet is adapted, we can achieved such index:concentrate grade of 63.65%, Fe recovery of 47.12% based on the ore grade of 10.05%.. According to the experimental result analysis, most of the iron minerals could be used to support the steel production of LingGang Group.Single magnetic process proved to be an suitable and promising process to conduct the fine particles of lean magnitite.

The box-culvert jacking of highway constructions crossing the existing railway is construction difficult and technically complex. If there are safe accidents, it will bring great loss. According to this situation, a new method based on WBS-RBS is presented in this paper to comprehensively identify the risk factors of safety accident with the fault tree, and then the fuzzy probability of basic events are described to triangle fuzzy numbers. Furthermore the happening fuzzy probability of the top event can be calculated. The proposed method provides a scientific method for the safety risk analysis of similar engineering.

It is inevitable to make the new-built highways under-pass the existing railroad by virtue of high-speed development of the transportation in China. Since the relevant surveys on the safety risk evaluation of this kind of the project are lacked at this current stage as well as the limited referential sample data, the survey is to research the factors of safety risk and the self-characteristics as well as to build up the safety risk evaluation model by means of support vector machine plus the analysis with the help of the project example. It turns out that the analyzed result by means of the model has the propinquity with the expected result, as means the model with the limited samples is characterized of improving the objective correctness of the evaluation result in order to supply a scientific method for the safety evaluation of this kind of projects.

In order to improve the control accuracy of the coiling temperature of strip in the laminar cooling process when working condition is varying, an intelligent setting method of the cooling water volume is researched in this paper. The strip coiling temperature mechanism model is built firstly. Secondly, the key model parameters are identified with case-based reasoning (CBR) technology to improve the model accuracy. Lastly, the cooling water volume setting method based the model is proposed where disturbance input method is applied. The simulation result showed that the proposed method can improve the strip coiling temperature accuracy when the operation condition is changing. The strip coiling temperature accuracy can be improved due to the CBR technology which can adjust the key model parameters according to the varying operation condition. So, the setting values based the improved model are adjusted with the changing working condition, with self-adaptive ability.

Based on the material of EPDM, we develop specialized rubber material for low-temperature multi-effect distillation (LT-MED) conditions. For heat transfer tube and tube sheet connected to the rubber (herein referred as EPDM rubber material) ring are used in the LT-MED desalination equipment, we make regular aging and multivariate synergistic aging test on EPDM. According to the experimental results, we develop an evaluation method applicable to usage of sealing rubber material under LT-MED conditions, and rubber material properties are measured by the changes of mechanical indicators. Finally, we also tested the sealing performance of the sealing rings. The results show that EPDM rubber material can tolerate the LT-MED conditions with the ring boost rate of 0.038kPa/h when the rates of change in Shoer hardness range from-5% to 10%, the rates of change in tensile strength within-20%, the rates of change in elongation at break range from-30% to 10%.

A nano-particle array grating is proposed to achieve fine polarized output and transmittance on GaN-based LED. This nanostructure enables simple fabrication, since the novel arrays can be directly coated on the surface of GaN. In this letter, Aluminum nano-particle array gratings are optimized at blue and green band respectively. Extinction ratio up to 26dB and a TM polarized transmittance of 76% are achieved. Theoretical results show the nano-particle grating can be a guidance in designing the integrated GaN based and polarized photonic devices. Numerical simulations are performed using the Finite-difference time-domain (FDTD) solutions.

In this work the adsorption of phosphate using the magnetic Fe-Zn bimetal oxide modified fly ash was studied. The experimental results showed that the effective pH range for the adsorption of phosphate was between 3.0 and 9.0. The removal percentage of phosphate reached maximum at pH 8.0. Kinetic study showed that the phosphate adsorption was well described by pseudo second order model. The removal efficiency of phosphate increased with the increase of adsorbent dosage and the decrease of the initial concentration. The adsorption of phosphate could be described well by Langmuir isotherm, the Langmuir constant Q0 was 24.15mg/g.

Structured light 3D measurement technology with its simple structure, non-contact measurement, fast measurement speed and other advantages, has been widely used. Steel plate surface quality detection is not confined to the two-dimensional feature of gray detection, and local topography measurement for surface quality of steel plate detection becomes increasingly important. In this paper, steel plate surface 3D detection method based on structured light and the factors affecting the measurement accuracy are analyzed. Several effective methods of improving 3D detection accuracy are put forward. Compared with the traditional structured light 3D detection methods, the detection accuracy of new methods is remarkably improved, thus possessing better application values.

Dense Chinese Fir LVL was manufactured from Chinese Fir veneer which was impregnated with laboratory prepared water soluble phenol formaldehyde(PF) resin. The influences of various processing factors on properties of dense Chinese Fir LVL were explored. It is showed that the mechanical properties of dense Chinese Fir LVL first increase and then decrease with the increase of drying temperature and hot-pressing time. Plank performance becomes higher with the increase of compressibility and hot-pressing temperature. The optimum technological parameters for LVL process are set.

In this paper, novel active narrowband notch filters with triple-layer composite nanostructures on a GaN-based LED are obtained by mainly adjusting the grating period and duty cycle. The three layers consist of two dielectric thin layers and one metallic / dielectric grating layer. The grating layer composes of subwavelength period and thickness rectangular stripes, which lies between a transition layer and a protecting layer. Line-width and attenuation peak properties of the resonance filters are calculated and investigated by using a full vector implementation of Rigorous Coupled Wave Analysis (RCWA) algorithm. It is shown that the grating period can significantly change the filter peak wavelength, and the grating duty cycle heavily changes the filter line-width. The filter attenuation peak has a red shift with 23.3nm as the grating period increases 18nm. The FWHM (Full Width at Half Maximum) of the filter reduces from 1.9nm to 0.28nm as the duty cycle changes from 0.55 to 0.3, which compressed more than six times. Moreover, thickness of each composite nanostructure layer can also affect the narrowband width and peak wavelength of the filter. The results provide guidance in designing, optimizing and fabricating such an active narrowband filter with highly integrated photonic devices.

In this paper, an improved algorithm of general radial basis (RBF) function neural network is introduced, based on improved algorithm, the neural network realized quickly fault diagnosis and self-update of neural network structure, and the neural network is applied to the on-line fault diagnosis expert system. The expert system deals with the fault data that send from on-line monitoring equipment by using neural network, and it can discover the fault type and give reasonable solution by forward reasoning. Meanwhile, the expert system has the ability of achieving new knowledge based on the application of self-update ability of RBF neural network.

Conventional methods that perform lung segment -ation in CT slices rely on a large contrast in hounsfield units between the lung and surrounding tissues. However, the lung fields are affected by high density pathologies, and they are discontinuities in the pixel intensities, the traditional segment- ation methods can’t get the good results. Here, we present a new segmentation method of the active contour, which is constraining with respect to a set of fixed reference shapes of lung fields. This approach is based on the shapes descriptors by the legendre moments computed from the shape regions, and it can be used in some complex lung field segmentation, especially suitable for the segmentation of lung field with the juxta-pleural pulmonary nodules. Experiments illustrate that the proposed method is able to segment the lung fields in the CT images successfully.

Offshore wind farm is developed in the ascendant currently. The reliable operation, power loss, investment cost and performance of wind farms were effect by the integration solutions of electrical interconnection system directly. Several new integration configurations based on VSC-HVDC were comparative analyzed. For the new HVDC topology applied the wind farm internal DC bus, the Variable Speed DC (VSDC) system that is suitable for those topologies was proposed. The structure of VSDC was discussed and maximum wind power tracking was simulated on the minimal system. It is clear that new integration configurations based on VSC-HVDC has good prospects.

The adsorption of copper in aqueous solutions by steel slag was studied in batch adsorption experiments. The adsorption equilibrium data fitted best with Langmuir and Freundlich equations. The adsorption was preferential type. A comparison of the kinetics models on the apparent adsorption rate showed that the adsorption system was best described by the pseudo-second-order kinetics. The adsorption rate was controlled by both liquid film diffusion and intraparticle dispersion.

In some e-commerce system, users do not know performance of commodities described by numeric values, but they can provide conceptual descriptions, such as “high”, “medium” and “low” on its price. The query based on concepts as inputs is named conceptual query. The basic method of conceptual query is to convert user's fuzzy concept into standard SQL statement based on the domain knowledge. However, if a condition is composed of the high and multilevel concepts, then its conversion of the concepts is very complex. Its efficiency will be poor. A new knowledge-based query method on multilevel generalized data is proposed in this paper. The knowledge of fuzzy concepts needs to be established, and multilevel generalized data is generated, a knowledge-based multilevel query is achieved on generalized data. Experiments on the synthetic data sets show that on a higher level and multiple levels the query efficiency of the method proposed in the paper is better than the basic method. The knowledge-based conceptual query on multilevel generalized data will provide efficient methods for the query about housing products in rural town and can meet the needs of customers with different knowledge, and has higher practical value.

With the development of RFID technology, we can identify, locate, track and monitor items in supply chain, retail store, and asset management applications. RFID has become a key technology in the Internet of Things. But RFID data can’t be effectively managed by only using traditional data model because they have their own unique characteristics, such as aggregation, location, temporal and history-oriented, which have to be fully considered and integrated into the data model. Therefore, the architecture of RFID spatio-temporal data management is proposed in this paper. We provide a brief overview of RFID technology and highlight a few of the spatio-temporal data management challenges, such as RFID middleware, RFID event processing, In-memory cache.

This paper proposed a preprocessing method of SWCNTs dispersion based on rinsing technology. With the assistance of SDS, SC and SDBS, this method adopted the ultrasonication oscillation technology to solve the problem of SWCNTs dispersion. In addition, it compared the effect of the three kinds of surfactants on SWCNTs dispersion under the same conditions. And AFM was applied in this experiment to scan and image the samples. The results showed that the solubility and adsorption efficiency of the surfactants had influence on the SWCNTs dispersion quality. Furthermore, the paper primarily and theoretically modeled and analyzed the experiment results from the aspect of the surfactants' hydrophilic and lipophilic structure.

Highly polarized light transmission from GaN based light emitting diode is proposed using a double-layer metallic grating film and a dielectric transition layer. TM mode transmission and the polarized extinction ratio (ER) are calculated using commercial software, based on a full vector implementation of Rigorous Coupled Wave Analysis (RCWA) algorithm. Such a thin-film double-layer grating with subwavelength metallic stripes are designed and simulated by perfect parameters of period, thickness and filling factor for achieving good polarization properties. It is found that TM transmission and ER are almost stable and flat under different slit arrays of the double-layer grating. The polarized structure shows larger width of incident wavelength with a transition layer of a low refractive index than that of a high refractive index, but higher TM transmission and ER can be obtained for low refractive index transition layer. Flat sensitivity and high transmission of the TM mode on the double-layer metal grating thickness have been achieved. Up to 100nm range of the grating height can be employed to achieve TM transmission more than 92% while ER> 20dB. The results provide guidance in designing, optimizing and fabricating the integrated GaN-based and polarized photonic devices.

It has been shown that learning to rank approaches are capable of learning highly effective ranking functions. However, these approaches have mostly ignored the important issue of efficiency. Given that both efficiency and effectiveness are important for real search engines, models that are optimized for effectiveness may not meet the strict efficiency requirements necessary to deploy in a production environment. In this work, we present a unified framework for jointly optimizing effectiveness and efficiency. We propose new metrics that capture the tradeoff between these two competing forces and devise a strategy for automatically learning models that directly optimize the tradeoff metrics. Experiments indicate that models learned in this way provide a good balance between retrieval effectiveness and efficiency. With specific loss functions, learned models converge to familiar existing ones, which demonstrate the generality of our framework. Finally, we show that our approach naturally leads to a reduction in the variance of query execution times, which is important for query load balancing and user satisfaction.

Semiconducting nanowires offer the possibility of nearly unlimited complex bottom-up design, which allows for new device concepts. However, essential parameters that determine the electronic quality of the wires, and which have not been controlled yet for the III–V compound semiconductors, are the wire crystal structure and the stacking fault density. In this paper, we have used the molecular dynamics simulations to study the formation of the stacking faults in GaN NW along [0001] and [11-20] directions. The results show that under same growth condition the GaN NW along [0001] has stacking fault while there is no stacking fault in GaN NW along [11-20]. We have analysis the possible reason and further study is underway.

Base on the practical experience of reinforcing engineering and the application of new type of cement based grouting material in recent years, a new type of cement-based concrete for strengthening engineering with high-bonding, low-shrinking, self-compacted was developed in this paper. Fast-speed strengthening and repairing of structures can be realized by combining this new strengthening material with the traditional method of increasing section area for strengthening, and by the adoption of the technology of perfusion pumped on-site. This new strengthening concrete can be applied to both reinforced concrete structures strengthening and masonry structures strengthening. Compared with the traditional strengthening method of increasing section area, due to smaller section needed, the construction speed is quicker, and the quality can be more easily guaranteed. Therefore, this new type of material possesses a wide application prospect. And a series of experimental researches on the mechanical properties of this new strengthening concrete is conducted in this paper.

Flatness is a crucial parameter describing geometry of the steel strip surface. Measurement of flatness is very important for control of strip shapes. In the paper, the phase shift algorithm was introduced in measurement of flatness, and a new flatness measuring system based on the phase shift technique was developed. A new formula was derived to compute phase value from one single fringe image, which made higher spatial resolution. The system can avoid adverse effects caused by motion of the strip. Compared with present flatness measuring systems, the system presented in the paper gained more accurate results of flatness measurement.

Toll evasion is a known challenging problem in expressway transportation. Existing solutions mainly rely on the audit by people on the spot. However, with the increase of expressway networks, this kind of methods become less practical and lead to low efficiency. Considering this deficiency, this paper presents a method based on data mining to automatically assist the toll audit. Our method not only takes use of the data recorded from the expressway toll system, but also brings convenience to the auditing process.

Aiming at the problem of tight coupling and interface complexity of WebService based on XML-RPC interactive model, this paper proposed the REST-based WebService, and gave out the design method of each part, including the design of restful Resource-Oriented Architecture, design of request and response interactive model and design of service discovery architecture based on semantic search. This research result was applied into an actual project, which indicated this WebService is loose coupling, interface uniform, portability, reliability and has good web-scale scalability features. Finally, an example is presented to illustrate this WebService architecture.

In solvent extraction system of perrhenate with the extractant of N235 at high concentration, the equilibrium molalities of ReO4- were measured at ionic strengths from 0.2 to 2.0 mol.kg-1 in the aqueous phase containing Na2SO4 as the supporting electrolyte from 278.15K to 303.15K. The standard extraction constants K0 at various temperatures were obtained. Thermodynamic quantities for the extraction process were also calculated.

Single-wall carbon nanotubes are candidates for a number of building blocks in nanoscale electronics. With respect to the assembly of carbon nanotube field effect transistor, the dielectrophoresis technology is adopted, which assembles SWCNTs between the micro-electrodes, SWCNTs are affected by the electrophoretic force which is carried out by the related theoretical analysis in a nonuniform electric field. The driving electric field of dielectrophoresis is simulated by the comsol software. According to the simulation results, a number of the experiments are done. It turns out that the required experimental parameters of the efficient assembly of SWCNT were obtained. AFM scanning and electrical properties of SWCNTs show that the method can achieve the effective assembly of carbon nanotube field effect transistor. SWCNTs are driven in the microelectrode gap, having a good arrangement of uniform orientation and assembly results, and proportional to the arrangement density along the electrode width direction and the duration of DEP. Meanwhile, it also provides an effective method of assembly and manufacture for other one-dimensional nanomaterials assembly of nanoelectronic devices.

The extraction kinetics of molybdenum(VI) with trialkyl amine (N235, R3N, R = C8–C10) dissolved in heptane has been investigated by constant interfacial cell with laminar flow. The stiochiometry and the equilibrium constant of the extracted complex formation reaction between Mo(VI) and N235 are determined. The influences of stirring speed, temperature, concentrations of extractant and chlorine on the extraction rate has been studied. It can be concluded that the mass transfer process is a mixed chemical reaction - diffusion controlled. The extraction rate equations and the rate-determining step have been obtained under the experimental conditions by predictions derived from interfacial reaction models. Based on the approximate solutions of the flux equation, diffusion parameters and thickness of the diffusion film have been calculated.

The progress of the application of microwave pyrolysis in China and oversea is reviewed. Introduce the methods and mechanism of produce high value-added chemicals through microwave heating of biomass, sludge and fossil fuel. And there should non-thermal effect existing in the microwave pyrolysis, and is worth to explore a way for the efficient fast pyrolysis of resources utilization of validity.