879 results
Search Results
2. Uncemented science at its best!: What makes a paper successful, meaning in this case much cited?
- Author
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Anne Lübbeke
- Subjects
Orthopedic surgery ,RD701-811 - Published
- 2020
- Full Text
- View/download PDF
3. How registry data can improve outcomes from joint replacement - a seminal paper.
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Tucker K
- Subjects
- Registries, Arthroplasty, Replacement
- Published
- 2020
- Full Text
- View/download PDF
4. Original Papers
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Michel Guez
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Orthopedics and Sports Medicine ,Surgery ,General Medicine - Published
- 2006
5. Uncemented science at its best!: What makes a paper successful, meaning in this case much cited?
- Author
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Lübbeke, Anne
- Subjects
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FRACTURE fixation , *SERIAL publications , *SURVIVAL , *TOTAL hip replacement , *CITATION analysis - Abstract
The article offers information on the influence of implant fixation on prosthesis longevity evaluated in the interplay with the individual prosthesis brands. It mentions the risk of stem revision for periprosthetic fracture after surgery. It mentions that periprosthetic fracture as more common cause of revision after uncemented than after cemented fixation.
- Published
- 2020
- Full Text
- View/download PDF
6. Original Papers.
- Author
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Guez, Michel
- Subjects
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CHRONIC pain , *NECK pain , *WHIPLASH injuries , *INFLAMMATION , *SOCIODEMOGRAPHIC factors - Abstract
Chronic neck pain, a common cause of disability, seems to be the result of several interacting mechanisms. In addition to degenerative and inflammatory changes and trauma, psychological and psychosocial factors are also involved. One common type of trauma associated with chronic neck pain is whiplash injury; this sometimes results in whip-lash-associated disorder (WAD), a controversial condition with largely unknown pathogenetic mechanisms. We studied the prevalence of chronic neck pain of traumatic and non-traumatic origin and compared the prevalence of, sociodemographic data, self-perceived health, workload and chronic lowback pain in these groups. In a ready-made questionnaire (MONICA study), we added questions about cervical spine and low-back complaints. 6,000 (72%) completed a self-administered questionnaire. 43% reported neck pain: 48% of women and 38% of men. Women of working age had more neck pain than retired women, a phenomenon not seen in men. 19% of the studied population suffered from chronic neck pain and it was more frequent in women. A history of neck trauma was common in those with chronic neck pain. Those with a history of neck trauma perceived their health worse and were more often on sick-leave. About 50% of those with traumatic and non-traumatic chronic neck pain also had chronic low-back pain. We assessed the subjective and objective neuropsychological functioning in 42 patients with chronic neck pain, 21 with a whiplash trauma, and 21 without previous neck trauma. Despite cognitive complaints, the WAD patients had normal neuropsychological functioning, but the WAD group especially had deviant MMPI results—indicating impaired coping ability and somatization.WAD patients had no alterations in cerebral blood-flow pattern, as measured by rCBF-SPECT and SPM analysis, compared to healthy controls. This contrasts with the non-traumatic group with chronic neck pain, which showed marked blood-flow changes. The blood-flow changes in the non-trau-matic group were similar to those described earlier in pain patients but— remarkably enough—were different from those in the WAD group. Chronic neck pain of whiplash and non-traumatic origin appears to be unique in some respects. A better understanding of the underlying pathological mechanisms is a prerequisite for prevention of the development of such chronic pain syndromes and for improvement of the treatment of patients with severe symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
7. The rise of registry-based research: a bibliometric analysis.
- Author
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Romanini, Emilio, Schettini, Irene, Torre, Marina, Venosa, Michele, Tarantino, Alessio, Calvisi, Vittorio, and Zanoli, Gustavo
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REPORTING of diseases ,RESEARCH methodology ,BIBLIOMETRICS ,ARTHROPLASTY ,QUANTITATIVE research ,MEDICAL care research ,ORTHOPEDICS ,DATA analysis software - Abstract
Background and purpose — The main purpose of arthroplasty registries is to collect information on patients, techniques, and devices to monitor and improve the outcome of the specific procedure. This study analyses the role played by registries in the orthopedic research community and describes publication trends, characteristics, and patterns of this field of research. Patients and methods — A descriptive-bibliometric review was conducted. Scopus was the database used for the research. All articles published from 1991 to December 2020 containing keywords related to registries and arthroplasty were considered. In particular, the following dimensions were analyzed in detail: (i) papers/year; (ii) journals; (iii) countries; (iv) research growth rate; (v) collaboration among countries. VOSviewer software was used to perform the bibliometric analysis. Finally, the 50 most cited papers of the last 10 years were briefly analyzed. Results — 3,933 articles were identified. There has been growing interest in the topic since 2010. Acta Orthopaedica ranked first for the number of articles published. The country with the largest number of articles citing registries was the United States, followed by the United Kingdom and Sweden. The relative number of articles per 100,000 inhabitants is 0.60 for Europe and 0.38 for the United States. The literature in this research area has an average yearly growth rate of 28%. Interpretation — The publication rate in the field of arthroplasty registries is constantly growing with a noteworthy impact in the evolution of this research and clinical area. The growth rate is significantly higher than that of arthroplasty literature (28% vs. 10%) and the collaboration among countries is strong and increasing with time. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. Summary of Papers l-lll.
- Author
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Young, Sven
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HIV infection complications ,POVERTY areas ,DATABASES ,FEMUR injuries ,BONE fractures ,INFECTION ,MEDICAL information storage & retrieval systems ,SURGICAL complications - Abstract
The article presents three abstracts of articles about intramedullary nail operations, including one by S. Young, S. A. Lie, G. Hallan et al. on low infection rates in intramedullary nail operations in 55 low and middle income countries (LMIC), one by S. Young, S. A. Lie, G. Hallan et al. on risk factors for infection after intramedullary nail operations in LMIC and one by S. Young, L. Banza, G. Hallan et al. on complications after intramedullary nailing of femoral fractures in LIMC.
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- 2014
9. Shoulder instability surgery in Norway
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Blomquist, Jesper, Solheim, Eirik, Liavaag, Sigurd, Schroder, Cecilie P, Espehaug, Birgitte, and Havelin, Leif I
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Adult ,Joint Instability ,Male ,Reoperation ,Adolescent ,Norway ,Shoulder Joint ,Incidence ,Middle Aged ,Prognosis ,Original Papers ,Arthroplasty ,Diagnostic Self Evaluation ,Young Adult ,Treatment Outcome ,Recurrence ,Surveys and Questionnaires ,Humans ,Female ,Registries ,Child ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
Background and purpose In January 2008, we established the Norwegian Register for Shoulder Instability Surgery. We report on the establishment, the baseline data, and the results at 1-year follow-up. Methods Primary and revision shoulder stabilization is reported by the surgeon on a 1-page paper form containing the patient's history of shoulder injury, clinical findings, and perioperative findings. The WOSI questionnaire for self-assessment of shoulder function is completed at baseline and at follow-up after 1, 2, and 5 years. To evaluate the completeness of registration, we compared our data with those in the Norwegian Patient Registry (NPR). Results The NPR reported 39 hospitals performing shoulder stabilizations. 20 of these started to report to our register during 2009, and 464 procedures (404 primary, 59 revisions) were included up to December 31, 2009, which represented 54% of the procedures reported to NPR. Of the 404 primary procedures, 83% were operations due to anterior instability, 10% were operations due to posterior instability, and 7% were operations due to multidirectional instability. Arthroscopic soft tissue techniques were used in 88% of the patients treated for primary anterior instability and open coracoid transfer was used in 10% of such patients. At 1-year follow-up of 213 patients, we found a statistically significantly improved WOSI score in all types of instability. 10% of the patients treated with arthroscopic anterior labral repair and 16% treated with arthroscopic posterior labral repair reported recurrent instability. No statistically significant difference in functional improvement or rate of recurrence was found between these groups. Interpretation The functional results are in accordance with those in previous studies. However, the incidence of recurrent instability 1 year after arthroscopic labral repair is higher than expected.
- Published
- 2012
10. The Exeter femoral stem continues to migrate during its first decade after implantation
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Nieuwenhuijse, Marc J, Valstar, Edward R, Kaptein, Bart L, and Nelissen, Rob G H H
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Male ,Arthroplasty, Replacement, Hip ,Bone Cements ,Middle Aged ,Prosthesis Design ,Radiostereometric Analysis ,Original Papers ,Osteoarthritis, Hip ,Prosthesis Failure ,Arthritis, Rheumatoid ,Treatment Outcome ,Humans ,Female ,Hip Joint ,Spondylitis, Ankylosing ,Femur ,Hip Prosthesis ,Longitudinal Studies ,Postoperative Period ,Prospective Studies ,Aged ,Follow-Up Studies - Abstract
Background Due to its collarless, double-tapered polished design, the Exeter femoral stem is known to migrate distally in the first 5 years after implantation. However, its long-term migration pattern has not been investigated. Patients and methods 39 consecutive patients (41 total hip arthroplasties) received a cemented Exeter stem and had prospective clinical and RSA follow-up. Patients were evaluated postoperatively at 6, 12, 26, and 52 weeks, and annually thereafter. Short-term results have been reported. In this study, the mean length of follow-up was 9.4 years (SD 3.2 years). No patients were lost to follow-up. 15 patients died during follow-up. Results No stems were revised. In 4 stems, fractures of the cement mantle were noted within the first 3 postoperative years. In 3 stems, this resulted in a complete circumferential cement mantle discontinuity. For the 37 well-performing stems, continuous but small migration was measured between 2 and 12 years of follow-up. Continued subsidence of 0.08 mm/year (95% CI: 0.05–0.12, p < 0.001) was seen in combination with continued rotation in retroversion of 0.07°/year (95% CI: 0.02–0.12, p = 0.01). At 10 years of follow-up, mean subsidence was 2.1 (SD 1.2) mm and mean retroversion was 1.8° (SD 2.0). Two-thirds of this occurred during the first 2 postoperative years. In the 3 stems with a complete circumferential cement fracture, a sudden and disproportionately high increase in subsidence was measured in the time period of occurrence. Interpretation The Exeter femoral stem continues to migrate during the first decade after implantation. Absolute stability is not required for good long-term survival if this is compatible with the design of the implant.
- Published
- 2012
11. Stable fixation of an osseointegated implant system for above-the-knee amputees
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Nebergall, Audrey, Bragdon, Charles, Antonellis, Anne, Kärrholm, Johan, Brånemark, Rickard, and Malchau, Henrik
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Adult ,Male ,Artificial Limbs ,Middle Aged ,Prosthesis Design ,Radiostereometric Analysis ,Original Papers ,Amputation, Surgical ,Prosthesis Failure ,Amputees ,Osseointegration ,Humans ,Female ,Bone Remodeling ,Femur ,Longitudinal Studies ,Bone Resorption ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
Background and purpose Rehabilitation of patients with transfemoral amputations is particularly difficult due to problems in using standard socket prostheses. We wanted to assess long-term fixation of the osseointegrated implant system (OPRA) using radiostereometric analysis (RSA) and periprosthetic bone remodeling. Methods 51 patients with transfemoral amputations (55 implants) were enrolled in an RSA study. RSA and plain radiographs were scheduled at 6 months and at 1, 2, 5, 7, and 10 years after surgery. RSA films were analyzed using UmRSA software. Plain radiographs were graded for bone resorption, cancellization, cortical thinning, and trabecular streaming or buttressing in specifically defined zones around the implant. Results At 5 years, the median (SE) migration of the implant was –0.02 (0.06) mm distally. The rotational movement was 0.42 (0.32) degrees around the longitudinal axis. There was no statistically significant difference in median rotation or migration at any follow-up time. Cancellization of the cortex (plain radiographic grading) appeared in at least 1 zone in over half of the patients at 2 years. However, the prevalence of cancellization had decreased by the 5-year follow-up. Interpretation The RSA analysis for the OPRA system indicated stable fixation of the implant. The periprosthetic bone remodeling showed similarities with changes seen around uncemented hip stems. The OPRA system is a new and promising approach for addressing the challenges faced by patients with transfemoral amputations.
- Published
- 2012
12. The effect of adding tobramycin to Simplex P cement on femoral stem micromotion as measured by radiostereometric analysis
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Bohm, Eric, Petrak, Martin, Gascoyne, Trevor, and Turgeon, Thomas
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musculoskeletal diseases ,Aged, 80 and over ,Male ,Arthroplasty, Replacement, Hip ,Bone Cements ,Methylmethacrylate ,Middle Aged ,Radiostereometric Analysis ,Original Papers ,Anti-Bacterial Agents ,Biomechanical Phenomena ,Prosthesis Failure ,Treatment Outcome ,Tobramycin ,Humans ,Female ,Hip Joint ,Femur ,Hip Prosthesis ,Longitudinal Studies ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
Background Previous in vitro research on addition of antibiotics to bone cement has found no statistically significant deterioration in mechanical properties. However, no clinical studies have compared the performance of tobramycin-laden bone cement with that of standard bone cement (Simplex P). Patients and Methods 23 patients (25 hips) were randomized to receive an Exeter (Stryker Orthopaedics) femoral stem cemented with either Simplex P (standard) or Simplex T (tobramycin-laden) cement. There were 2 years of follow-up, with scheduled radiostereometric (RSA) examinations. Results All stems migrated distally and showed some degree of retroversion. No clinically significant differences in stem subsidence or retroversion were found between the Simplex T and Simplex P cement groups after 2 years. Overall subsidence was less than in previous studies, probably due to a postponed initial post-surgical examination. Rates of subsidence in both cement groups were consistent with those from previous studies of Exeter stems. Interpretation Subsidence of the femoral stem after 2 years was similar in the Simplex T (tobramycin-laden) and Simplex P (standard) groups.
- Published
- 2012
13. Factors predisposing to claims and compensations for patient injuries following total hip and knee arthroplasty
- Author
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Unto Häkkinen, Gunnar Rosenqvist, Ville Remes, and Jutta Järvelin
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musculoskeletal diseases ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Arthroplasty, Replacement, Hip ,Comorbidity ,Logistic regression ,Prosthesis ,Patient safety ,Insurance Claim Review ,Sex Factors ,Quality of life ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Registries ,Arthroplasty, Replacement, Knee ,Finland ,Multinomial logistic regression ,Aged ,Retrospective Studies ,ta112 ,business.industry ,Malpractice ,Age Factors ,Retrospective cohort study ,General Medicine ,Articles ,medicine.disease ,Insurance, Liability ,Arthroplasty ,Original Papers ,Hospitals ,Logistic Models ,Compensation and Redress ,Physical therapy ,Surgery ,Female ,Hip Prosthesis ,Patient Safety ,business ,Knee Prosthesis - Abstract
Background and purpose Factors associated with malpractice claims are poorly understood. Knowledge of these factors could help to improve patient safety. We investigated whether patient characteristics and hospital volume affect claims and compensations following total hip arthroplasty (THA) and knee arthroplasty (TKA) in a no-fault scheme. Methods A retrospective registry-based study was done on 16,646 THAs and 17,535 TKAs performed in Finland from 1998 through 2003. First, the association between patient characteristics—e.g., age, sex, comorbidity, prosthesis type—and annual hospital volume with filing of a claim was analyzed by logistic regression. Then, multinomial logistic regression was applied to analyze the association between these same factors and receipt of compensation. Results For THA and TKA, patients over 65 years of age were less likely to file a claim than patients under 65 (OR = 0.57, 95% CI: 0.46–0.72 and OR = 0.65, CI: 0.53–0.80, respectively), while patients with increased comorbidity were more likely to file a claim (OR = 1.17, CI: 1.04–1.31 and OR = 1.14, CI: 1.03-1.26, respectively). Following THA, male sex and cemented prosthesis reduced the odds of a claim (OR = 0.74, CI: 0.60–0.91 and OR = 0.77, CI: 0.60–0.99, respectively) and volume of between 200 and 300 operations increased the odds of a claim (OR = 1.29, CI: 1.01–1.64). Following TKA, a volume of over 300 operations reduced the probability of compensation for certain injury types (RRR = 0.24, CI: 0.08–0.72). Interpretation Centralization of TKA to hospitals with higher volume may reduce the rate of compensable patient injuries. Furthermore, more attention should be paid to equal opportunities for patients to file a claim and obtain compensation.
- Published
- 2012
14. Low BMD affects initial stability and delays stem osseointegration in cementless total hip arthroplasty in women
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Jessica J. Alm, Niko Moritz, Petteri Lankinen, Hannu T. Aro, and Tatu J. Mäkinen
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Adult ,Joint Instability ,musculoskeletal diseases ,Aging ,medicine.medical_specialty ,WOMAC ,Bone density ,Arthroplasty, Replacement, Hip ,medicine.medical_treatment ,Osteoporosis ,Dentistry ,Radiostereometric Analysis ,Osteoarthritis, Hip ,Bone Density ,Osseointegration ,Risk Factors ,medicine ,Humans ,Orthopedics and Sports Medicine ,Longitudinal Studies ,Aged ,Retrospective Studies ,Hip surgery ,Bone mineral ,business.industry ,General Medicine ,Middle Aged ,musculoskeletal system ,medicine.disease ,Original Papers ,Arthroplasty ,Prosthesis Failure ,Surgery ,Osteopenia ,Bone Diseases, Metabolic ,Logistic Models ,Harris Hip Score ,Female ,Hip Joint ,Hip Prosthesis ,business - Abstract
Background and purpose Immediate implant stability is a key factor for success in cementless total hip arthroplasty (THA). Low bone mineral density (BMD) and age-related geometric changes of the proximal femur may jeopardize initial stability and osseointegration. We compared migration of hydroxyapatite-coated femoral stems in women with or without low systemic BMD. Patients and methods 61 female patients with hip osteoarthritis were treated with cementless THA with anatomically designed hydroxyapatite-coated femoral stems and ceramic-ceramic bearing surfaces (ABG-II). Of the 39 eligible patients between the ages of 41 and 78 years, 12 had normal systemic BMD and 27 had osteopenia or osteoporosis. According to the Dorr classification, 21 had type A bone and 18 had type B. Translational and rotational migration of the stems was evaluated with radiostereometric analysis (RSA) up to 2 years after surgery. Results Patients with low systemic BMD showed higher subsidence of the femoral stem during the first 3 months after sur gery than did those with normal BMD (difference = 0.6, 95% CI: 0.1–1.1; p = 0.03). Low systemic BMD (odds ratio (OR) = 0.1, CI: 0.006–1.0; p = 0.02), low local hip BMD (OR = 0.3, CI: 0.1–0.7; p = 0.005) and ageing (OR = 1.1, CI: 1.0–1.2; p = 0.02) were risk factors for delayed translational stability. Ageing and low canal flare index were risk factors for delayed rotational stabilization (OR = 3, CI: 1.1–9; p = 0.04 and OR = 1.1, CI: 1.0–1.2; p = 0.02, respectively). Harris hip score and WOMAC score were similar in patients with normal systemic BMD and low systemic BMD. Interpretation Low BMD, changes in intraosseous dimensions of the proximal femur, and ageing adversely affected initial stability and delayed osseointegration of cementless stems in women.
- Published
- 2012
15. Total hip arthroplasty in young adults, with focus on Perthes' disease and slipped capital femoral epiphysis
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Lehmann, Trude G, Engesæter, Ingvild Ø, Laborie, Lene B, Lie, Stein Atle, Rosendahl, Karen, and Engesæter, Lars B
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musculoskeletal diseases ,Adult ,Male ,Sweden ,Norway ,Arthroplasty, Replacement, Hip ,Incidence ,Reproducibility of Results ,Slipped Capital Femoral Epiphyses ,Original Papers ,Osteoarthritis, Hip ,United Kingdom ,Legg-Calve-Perthes Disease ,Quality of Life ,Humans ,Female ,Registries ,Follow-Up Studies ,Retrospective Studies - Abstract
Background and purpose Pediatric hip diseases account for 9% of all primary hip arthroplasties in the Norwegian Arthroplasty Register. We wanted to validate the diagnosis as reported to the register and to assess the quality of life of these patients after hip replacement. Patients and methods 540 patients accepted to participate in this follow-up study (634 hips). All were less than 40 years of age and had been reported to the Norwegian Arthroplasty Register as having undergone a primary total hip arthroplasty (THA) between 1987 and 2007. The underlying diagnosis, age at diagnosis, and type of treatment given prior to the hip replacement were recorded from the original hospital notes. Results The diagnoses reported to the Norwegian Arthroplasty Register were confirmed to be correct in 91% of all cases (538/592). For the 94 hips that had been treated due to Perthes' disease or slipped capital femoral epiphysis (SCFE), the diagnosis was verified in 95% of cases (89/94). The corresponding proportion for inflammatory hip disease was 98% (137/140) and it was only 61% for primary osteoarthritis (19/31). The self reported quality of life (EQ-5D) was poorer for these young patients with THA than for persons in age-matched cohorts from Great Britain and Sweden, except for those with an underlying SCFE. Interpretation The diagnoses reported to the Norwegian Arthroplasty Register as the underlying cause of THA were correct in 91% of cases. Individuals who undergo THA before the age of 40 have a reduced quality of life, except for those requiring a hip replacement because of SCFE.
- Published
- 2012
16. Fixation of the fully hydroxyapatite-coated Corail stem implanted due to femoral neck fracture
- Author
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von Schewelov, Thord, Ahlborg, Henrik, Sanzén, Lennart, Besjakov, Jack, and Carlsson, Åke
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Aged, 80 and over ,Fracture Healing ,Male ,Arthroplasty, Replacement, Hip ,Prosthesis Design ,Radiostereometric Analysis ,Original Papers ,Femoral Neck Fractures ,Prosthesis Failure ,Fracture Fixation, Internal ,Absorptiometry, Photon ,Durapatite ,Treatment Outcome ,Bone Density ,Humans ,Female ,Femur ,Hip Prosthesis ,Longitudinal Studies ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
Background Today, dislocated femoral neck fractures are commonly treated with a cemented hip arthroplasty. However, cementing of the femoral component may lead to adverse effects and even death. Uncemented stems may lower these risks and hydroxyapatite (HA) coating may enhance integration, but prosthetic stability and clinical outcome in patients with osteoporotic bone have not been fully explored. We therefore studied fixation and clinical outcome in patients who had had a femoral neck fracture and who had received a fully HA-coated stem prosthesis. Patients and methods 50 patients with a dislocated femoral neck fracture were operated with the fully HA-coated Corail total or hemiarthroplasty. 38 patients, mean age 81 (70–96) years, were followed for 24 months with conventional radiographs, RSA, DEXA, and for clinical outcome. Results 31 of the 38 implants moved statistically significantly up to 3 months, mainly distally, mean 2.7 mm (max. 20 mm (SD 4.3)), and rotated into retroversion mean 3.3º (–1.8 to 17) (SD 4.3) and then appeared to stabilize. Distal stem migration was more pronounced if the stem was deemed to be too small. There was no correlation between BMD and stem migration. The migration did not result in any clinically adverse effects. Interpretation The fully hydroxyapatite-coated Corail stem migrates during the first 3 months, but clinical outcome appears to be good, without any adverse events.
- Published
- 2012
17. No adverse effects of submelt-annealed highly crosslinked polyethylene in cemented cups
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Stephan M. Röhrl, Bo Nivbrant, and Kjell G. Nilsson
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Male ,medicine.medical_specialty ,Time Factors ,Arthroplasty, Replacement, Hip ,medicine.medical_treatment ,macromolecular substances ,Outcome assessment ,Prosthesis Design ,Radiostereometric Analysis ,chemistry.chemical_compound ,Highly crosslinked polyethylene ,Outcome Assessment, Health Care ,Humans ,Medicine ,Prosthesis design ,Orthopedics and Sports Medicine ,Longitudinal Studies ,Prospective Studies ,Adverse effect ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Bone Cements ,technology, industry, and agriculture ,Clinical performance ,Follow up studies ,Femur Head ,General Medicine ,Middle Aged ,Polyethylene ,Original Papers ,Arthroplasty ,Biomechanical Phenomena ,Prosthesis Failure ,Surgery ,chemistry ,Female ,Hip Joint ,Hip Prosthesis ,business ,Follow-Up Studies - Abstract
Background and purpose Highly crosslinked polyethylene (PE) is in standard use worldwide. Differences in the crosslinking procedure may affect the clinical performance. Experimenatal data from retrieved cups have shown free radicals and excessive wear of annealed highly crosslinked PE. We have previously reported low wear and good clinical performance after 6 years with this implant, and now report on the 10-year results. Patients and methods In 8 patients, we measured wear of annealed highly crosslinked PE prospectively with radiostereometry after 10 years. Activity was assessed by UCLA activity score and a specifically designed activity score. Conventional radiographs were evaluated for osteolysis and clinical outcome by the Harris hip score (HHS). Results The mean (95% CI) proximal head penetration for highly crosslinked PE after 10 years was 0.07 (–0.015 to 0.153) mm, and the 3D wear was 0.2 (0.026 to 0.36) mm. Without creep, proximal head penetration was 0.02 (–0.026 to 0.066) mm and for 3D penetration was 0.016 (–0.47 to 0.08) mm. This represents an annual proximal wear of less than 2 µm. All cups were clinically and radiographically stable but showed a tendency of increased rotation after 5 years. Interpretation Wear for annealed highly crosslinked PE is extremely low up to 10 years. Free radicals do not affect mechanical performance or lead to clinically adverse effects. Creep stops after the first 6 months after implantation. Highly crosslinked PE is a true competitor of hard-on-hard bearings.
- Published
- 2012
18. Trochanteric stabilizing plate in the treatment of trochanteric fractures: a scoping review.
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Alm, Carl Erik, Gjertsen, Jan-Erik, Basso, Trude, Matre, Kjell, Rörhl, Stephan, Madsen, Jan Erik, and Frihagen, Frede
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BIOLOGICAL models ,STATISTICAL reliability ,SYSTEMATIC reviews ,HIP fractures ,BONE screws ,COMPARATIVE studies ,FRACTURE fixation ,REOPERATION ,LITERATURE reviews - Abstract
Background and purpose — The trochanteric stabilizing plate (TSP) may be used as an adjunct to a sliding hip screw (SHS) in the treatment of trochanteric fractures to increase construct stability. We performed a scoping review of the literature to clarify when and how the TSP may be useful. Methods — A systematic search was performed in 5 databases and followed by a backwards-and-forwards citation search of the identified papers. 24 studies were included. Results — 6 biomechanical studies and 18 clinical studies were included in the review. The studies presented mainly low-level evidence. All studies were on unstable trochanteric fractures or fracture models. Due to the heterogeneity of methods and reporting, we were not able to perform a meta-analysis. In the biomechanical trials, the TSP appeared to increase stability compared with SHS alone, up to a level comparable with intramedullary nails (IMNs). We identified 1,091 clinical cases in the literature where a TSP had been used. There were 82 (8%) reoperations. The rate of complications and reoperations for SHS plus TSP was similar to previous reports on SHS alone and IMN. It was not possible to conclude whether the TSP gave better clinical results, when compared with either SHS alone or with IMN. Interpretation — The heterogeneity of methods and reporting precluded any clear recommendations on when to use the TSP, or if it should be used at all. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
19. Patient-reported outcome after rheumatoid arthritis-related surgery in the lower extremities
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Anna Clara Benoni, Anna Nilsdotter, and Ann Bremander
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Adult ,Male ,medicine.medical_specialty ,Knee Joint ,medicine.medical_treatment ,Arthritis ,Arthroplasty ,Arthritis, Rheumatoid ,Quality of life ,Foot Joints ,Surveys and Questionnaires ,medicine ,Humans ,Orthopedics and Sports Medicine ,Registries ,Aged ,Retrospective Studies ,Aged, 80 and over ,Sweden ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Arthralgia ,Original Papers ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Lower Extremity ,Patient Satisfaction ,Rheumatoid arthritis ,Orthopedic surgery ,Quality of Life ,Female ,Hip Joint ,Patient-reported outcome ,Self Report ,Ankle ,business ,Ankle Joint ,Follow-Up Studies - Abstract
Background and purpose Although decreasing with the development of effective pharmacological regimes, joint surgery has improved the function and quality of life of patients with rheumatoid arthritis (RA). Few studies have assessed patient-reported outcomes after RA surgery to the lower extremities. Here we report patient-relevant outcome after RA-related surgery based on the first data from the Swedish National Register of Rheuma Surgery (RAKIR). Patients and methods 258 RA patients (212 women) who had joint surgery performed at the Department of Orthopaedics, Spenshult Hospital between September 2007 and June 2009 were included. Mean age at surgery was 64 (20–86) years. The patients completed the SF-36 and HAQ questionnaires preoperatively and 6 months postoperatively, and 165 patients completed them after 12 months. Results Improvement was seen as early as at 6 months. At 12 months, 165 patients (141 women)—including hip (n = 15), knee (n = 27), foot (n = 102), and ankle (n = 21) patients—reported statistically significant improvements from preoperatively to 12 months postoperatively in HAQ (mean change: –0.11) and SF-36 subscales physical function (11), role physical (12), bodily pain (13), social functioning (6.4), and role emotional (9.4). Hip and knee patients reported the greatest improvements. Interpretation Orthopedic RA-related surgery of the lower extremities has a strong effect on pain and physical function. Improvement is evident as early as 6 months postoperatively and remains after 12 months.
- Published
- 2011
20. The European Bone and Joint Infection Society definition of periprosthetic joint infection is meaningful in clinical practice: a multicentric validation study with comparison with previous definitions.
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SOUSA, Ricardo, RIBAU, Ana, ALFARO, Pedro, BURCH, Marc-Antoine, PLOEGMAKERS, Joris, MCNALLY, Martin, CLAUSS, Martin, WOUTHUYZEN-BAKKER, Marjan, and SORIANO, Alex
- Subjects
PROSTHESIS-related infections ,CONFIDENCE intervals ,FAMILY medicine ,RESEARCH methodology ,RETROSPECTIVE studies ,LONGITUDINAL method - Abstract
Background and purpose -- A new periprosthetic joint infection (PJI) definition has recently been proposed by the European Bone and Joint Infection Society (EBJIS). The goals of this paper are to evaluate its diagnostic accuracy and compare it with previous definitions and to assess its accuracy in preoperative diagnosis. Patients and methods -- We retrospectively evaluated a multicenter cohort of consecutive revision total hip and knee arthroplasties. Cases with minimum required diagnostic workup were classified according to EBJIS, 2018 International Consensus Meeting (ICM 2018), Infectious Diseases Society of America (IDSA), and modified 2013 Musculoskeletal Infection Society (MSIS) definitions. 2 years' minimum follow-up was required to assess clinical outcome. Results -- Of the 472 cases included, PJI was diagnosed in 195 (41%) cases using EBJIS; 188 (40%) cases using IDSA; 172 (36%) using ICM 2018; and 145 (31%) cases using MSIS. EBJIS defined fewer cases as intermediate (5% vs. 9%; p = 0.01) compared with ICM 2018. Specificity was determined by comparing risk of subsequent PJI after revision surgery. Infected cases were associated with higher risk of subsequent PJI in every definition. Cases classified as likely/confirmed infections using EBJIS among those classified as not infected in other definitions showed a significantly higher risk of subsequent PJI compared with concordant non-infected cases using MSIS (RR = 3, 95% CI 1-6), but not using ICM 2018 (RR = 2, CI 1-6) or IDSA (RR = 2, CI 1-5). EBJIS showed the highest agreement between preoperative and definitive classification (k = 0.9, CI 0.8-0.9) and was better at ruling out PJI with an infection unlikely result (sensitivity 89% [84-93], negative predictive value 90% [85-93]). Conclusion -- The newly proposed EBJIS definition emerged as the most sensitive of all major definitions. Cases classified as PJI according to the EBJIS criteria and not by other definitions seem to have increased risk of subsequent PJI compared with concordant non-infected cases. EBJIS classification is accurate in ruling out infection preoperatively. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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21. Discussion.
- Published
- 2014
22. Discussion.
- Author
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Young, Sven
- Subjects
HIV infection complications ,POVERTY areas ,FEMUR injuries ,BONE fractures ,COMPOUND fractures ,INFECTION ,SURGICAL complications ,TIBIA injuries ,HUMERUS injuries - Abstract
In this article the authors focus on three research projects on intramedullary nailing in low and middle income countries (LIMC) which they were involved in and which are discussed in three articles abstracted within the issue. In the article they offer opinions on research findings contained in the three abstracted articles and discuss the challenges that are associated with conducting surgery for fracture fixation in LIMC.
- Published
- 2014
23. The effect of erythropoietin on bone.
- Author
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Rölfing, Jan Hendrik Duedal
- Subjects
ANIMAL experimentation ,BONE regeneration ,BONE growth ,ACADEMIC dissertations ,DOSE-effect relationship in pharmacology ,ERYTHROPOIETIN ,HEALTH outcome assessment ,RABBITS ,RESEARCH funding ,SWINE ,IN vitro studies ,THERAPEUTICS - Abstract
The article discusses a PHD thesis project which investigated the efficacy of using erythropoietin to promote bone regeneration in pre-clinical experiments. The research, which evaluated the articles "Erythropoietin Augments Bone Formation in a Rabbit Posterolateral Spinal Fusion Model" by J. H. D. Rölfing, M. Bendtsen and J. Jensen et al. in the "Journal of Orthopedic Research",The Osteogenic Effect of Erythropoietin on Human Mesenchymal Stromal Cells Is Dose-Dependent and Involves Non-Hematopoietic Receptors and Multiple Intracellular Signaling Pathway" by J. H. D. Rölfing, A. Baatrup, M. Stiehler et al. in "Stem Cell Reeview" and "A Single Topical Dose of Erythropoietin Applied on a Collagen Carrier Enhances Calvarial Bone Healing in Pigs" by J. H. D. Rölfing, J. Jensen, J. N. Jensen et al. in "Acta Orthopaedica", found that erythropoietin was effective in bone regeneration.
- Published
- 2014
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24. The Danish Shoulder Arthroplasty Registry: clinical outcome and short-term survival of 2,137 primary shoulder replacements
- Author
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Stig Brorson, John Jakobsen, Bo S Olsen, and Jeppe V. Rasmussen
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,Denmark ,medicine.medical_treatment ,Osteoarthritis ,Arthroplasty ,Danish ,Quality of life ,Surveys and Questionnaires ,medicine ,Humans ,Orthopedics and Sports Medicine ,Registries ,Aged ,Pain Measurement ,Retrospective Studies ,Shoulder Joint ,business.industry ,Shoulder Fracture ,Shoulder Dislocation ,Retrospective cohort study ,General Medicine ,medicine.disease ,Original Papers ,language.human_language ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Short term survival ,Quality of Life ,Shoulder Fractures ,language ,Female ,Shoulder joint ,business - Abstract
The Danish Shoulder Arthroplasty Registry (DSR) was established in 2004. Data are reported electronically by the surgeons. Patient-reported outcome is collected 10–14 months postoperatively using the Western Ontario osteoarthritis of the shoulder index (WOOS). 2,137 primary shoulder arthroplasties (70% women) were reported to the registry between January 2006 and December 2008. Mean age at surgery was 69 years (SD 12). The most common indications were a displaced proximal humeral fracture (54%) or osteoarthritis (30%). 61% were stemmed hemiarthroplasties, 28% resurfacing hemiarthroplasties, 8% reverse shoulder arthroplasties, and 3% total arthroplasties. Median WOOS was 59% (IQR: 37–82). 5% had been revised by the end of June 2010. The most frequent indications for revision were dislocation or glenoid attrition.
- Published
- 2012
25. Radiographic evaluation of osteoarthritis of the hip: an inter-observer study of 61 hips treated for late-detected developmental hip dislocation
- Author
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Terje Terjesen and Ragnhild Gunderson
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Radiography ,Arthroplasty, Replacement, Hip ,Osteoarthritis ,Osteoarthritis, Hip ,medicine ,Prevalence ,Humans ,Orthopedics and Sports Medicine ,Developmental dislocation ,Longitudinal Studies ,Hip Dislocation, Congenital ,Retrospective Studies ,Orthodontics ,Observer Variation ,Developmental hip dislocation ,business.industry ,Reproducibility of Results ,Mean age ,General Medicine ,Middle Aged ,medicine.disease ,Original Papers ,Surgery ,Clinical Practice ,Orthopedic surgery ,Female ,Hip Joint ,business ,Kappa ,Follow-Up Studies - Abstract
Background and purpose Different methods have been used to classify osteoarthritis (OA) of the hip. We evaluated the reliability of different classifications in order to find which grading system is most appropriate for use in clinical practice. Patients and methods 49 patients (61 affected hips) with late-detected developmental dislocation of the hip (DDH) were studied. The mean age at follow-up was 45 (32–49) years. 3 classifications of OA were compared. The gradings by Kellgren and Lawrence (1957) (K&L) and Croft et al. (1990) are global visual assessments based on osteophytes, cysts, subchondral sclerosis, and narrowing of the joint space. The third classification is based on narrowing in the upper, weight-bearing part of the joint and defines as OA a minimum joint space width (JSW) of less than 2.0 mm at the narrowest part. 2 experienced observers, one radiologist and one orthopedic surgeon, assessed and measured the radiographs. Results Minimum JSW (< 2.0 mm in 9 hips) gave the best inter-observer agreement (kappa value = 0.87). Using the K&L grading, inter-observer agreement was moderate (kappa = 0.55), but kappa increased when the number of categories was reduced from 5 to 3 (no OA, mild OA, and severe OA). The Croft classification gave similar agreement as the K&L grading. The intra-observer agreement was better than inter-observer agreement, irrespective of the grading system. There was a good accordance between the minimum JSW and the 2 other methods. Interpretation Joint space narrowing using a minimum JSW of < 2.0 mm as criterion for OA was the simplest and most reproducible classification in long-term follow-up of patients with DDH. A classification based on global visual assessment can be used in addition if only hips with severe OA are included.
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- 2012
26. Validity, reliability, and responsiveness of a self-reported foot and ankle score (SEFAS)
- Author
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Dawson, Jill, Doll, Helen, Jenkinson, Crispin, Lavis, Grahame, Sharp, Robert, Cooke, Paul, Cöster, Maria, and Carlsson, Åke
- Subjects
Adult ,Male ,medicine.medical_specialty ,Intraclass correlation ,medicine.medical_treatment ,Ankle replacement ,Arthroplasty, Replacement, Ankle ,Disability Evaluation ,Physical medicine and rehabilitation ,Cronbach's alpha ,Foot Joints ,Surveys and Questionnaires ,Correspondence ,Osteoarthritis ,medicine ,Content validity ,Humans ,Orthopedics and Sports Medicine ,Aged ,Language ,Aged, 80 and over ,Sweden ,business.industry ,Arthritis ,Construct validity ,Reproducibility of Results ,General Medicine ,Middle Aged ,Original Papers ,Arthroplasty ,medicine.anatomical_structure ,Treatment Outcome ,Patient Satisfaction ,Orthopedic surgery ,Physical therapy ,Surgery ,Female ,Self Report ,Ankle ,business ,Ankle Joint ,New Zealand - Abstract
Background and purpose A questionnaire was introduced by the New Zealand Arthroplasty Registry for use when evaluating the outcome of total ankle replacement surgery. We evaluated the reliability, validity, and responsiveness of the modified Swedish version of the questionnaire (SEFAS) in patients with osteoarthritis or inflammatory arthritis before and/or after their ankle was replaced or fused. Patients and methods The questionnaire was translated into Swedish and cross-culturally adapted according to a standardized procedure. It was sent to 135 patients with ankle arthritis who were scheduled for or had undergone surgery, together with the foot and ankle outcome score (FAOS), the short form 36 (SF-36) score, and the EuroQol (EQ-5D) score. Construct validity was evaluated with Spearman’s correlation coefficient when comparing SEFAS with FAOS, SF-36, and EQ-5D, content validity by calculating floor and ceiling effects, test-retest reliability with intraclass correlation coefficient (ICC), internal consistency with Cronbach’s alpha (n = 62), agreement by Bland-Altman plot, and responsiveness by effect size and standardized response mean (n = 37). Results For construct validity, we correlated SEFAS with the other scores and 70% or more of our predefined hypotheses concerning correlations could be confirmed. There were no floor or ceiling effects. ICC was 0.92 (CI 95%: 0.88–0.95), Cronbach’s alpha 0.96, effect size was 1.44, and the standardized response mean was 1.00. Interpretation SEFAS is a self-reported foot and ankle score with good validity, reliability and responsiveness, indicating that the score can be used to evaluate patients with osteoarthritis or inflammatory arthritis of the ankle and outcome of surgery.
- Published
- 2012
27. Redeployment of the trainee orthopaedic surgeon during COVID-19: a fish out of water?
- Author
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Faria, Giles, Tadros, Baha John, Holmes, Natalie, Virani, Siddharth, Reddy, Gaddam Kumar, Dhinsa, Baljinder Singh, and Relwani, Jaikumar
- Subjects
ACADEMIC medical centers ,EMPLOYMENT reentry ,HOSPITAL medical staff ,ORTHOPEDICS ,SURGEONS ,THEMATIC analysis ,RETROSPECTIVE studies ,SECONDARY care (Medicine) ,TERTIARY care ,COVID-19 pandemic - Abstract
Background and purpose — COVID-19 has had a significant impact on health services and the entire healthcare sector, including trauma and orthopaedics, has been compelled to adapt. At the heart of this was the redeployment of the orthopaedic trainees to support "frontline specialties". This paper sheds light on the experience of orthopaedic trainees in redeployment. Methods — In this retrospective study, we asked orthopaedic trainees in the KSS (Kent, Surrey, Sussex) and London Deaneries to complete a survey regarding their experience in redeployment during the COVID-19 outbreak. The study took place in the Kent, Surrey, Sussex, and London regions of the United Kingdom over a period of 8 weeks from 15th of March 2020 until 15th of May 2020. The study was based at East Kent Hospitals University NHS Foundation Trust and participants were recruited from a number of secondary and tertiary care centres across the region. 120 orthopaedic trainees were contacted, working in 21 teaching hospitals. Of these, 40 trainees (30%) from 13 hospitals responded and completed the survey. Results — 50% of the surveyed trainees were redeployed to other specialties. Trainees spent varying amounts of time in the redeployed speciality and gave differing views on how comfortable they felt and how useful they felt the experience was. One-third of trainees experienced symptoms and/or tested positive for COVID-19 and the majority of these were redeployed to other specialties. Interpretation — Orthopaedic training appears to have taken a temporary back seat at this time but trainees have made a significant contribution to reinforcing key front-line specialties in the fight against COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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28. Physical child abuse demands increased awareness during health and socioeconomic crises like COVID-19: A review and education material.
- Author
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Martinkevich, Polina, Larsen, Lise Langeland, Græsholt-Knudsen, Troels, Hesthaven, Gitte, Hellfritzsch, Michel Bach, Petersen, Karin Kastberg, Møller-Madsen, Bjarne, and Rölfing, Jan Duedal
- Subjects
CHILD abuse ,HEALTH care teams ,HEALTH status indicators ,TEACHING aids ,SOCIOECONOMIC factors ,STAY-at-home orders ,COVID-19 pandemic - Abstract
Background and purpose — Physical abuse of children, i.e., nonaccidental injury (NAI) including abusive head trauma (AHT) is experienced by up to 20% of children; however, only 0.1% are diagnosed. Healthcare professionals issue less than 20% of all reports suspecting NAI to the responsible authorities. Insufficient knowledge concerning NAI may partly explain this low percentage. The risk of NAI is heightened during health and socioeconomic crises such as COVID-19 and thus demands increased awareness. This review provides an overview and educational material on NAI and its clinical presentation. Methods — We combined a literature review with expert opinions of the senior authors into an educational paper aiming to help clinicians to recognize NAI and act appropriately by referral to multidisciplinary child protection teams and local authorities. Results — Despite the increased risk of NAI during the current COVID-19 crisis, the number of reports suspecting NAI decreased by 42% during the lockdown of the Danish society. Healthcare professionals filed only 17% of all reports of suspected child abuse in 2016. Interpretation — The key to recognizing and suspecting NAI upon clinical presentation is to be aware of inconsistencies in the medical history and suspicious findings on physical and paraclinical examination. During health and socioeconomic crises the incidence of NAI is likely to peak. Recognition of NAI, adequate handling by referral to child protection teams, and reporting to local authorities are of paramount importance to prevent mortality and physical and mental morbidity. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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29. Cognitive training for the prevention of skill decay in temporarily non-performing orthopedic surgeons.
- Author
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Kelc, Robi, Vogrin, Matjaz, and Kelc, Janja
- Subjects
ABILITY ,ANXIETY ,APRAXIA ,CLINICAL competence ,COGNITION ,MEMORY ,MENTAL health ,PSYCHOLOGY of movement ,SURGEONS - Abstract
Surgical tasks are prone to skill decay. During unprecedented circumstances, such as an epidemic, personal illness, or injury, orthopedic surgeons may not be performing surgical procedures for an uncertain period of time. While not being able to execute regular surgical tasks or use surgical simulators, skill decay can be prevented with regular mental practice, using a scientifically proven skill acquisition and retaining tool. This paper describes different theories on cognitive training answering the question on how it works and offers a brief review of its application in surgery. Additionally, practical recommendations are proposed for performing mental training while not performing surgical procedures. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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30. Guidelines for a structured manuscript: Statistical methods and reporting in biomedical research journals.
- Author
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CHRISTENSEN, Robin, RANSTAM, Jonas, OVERGAARD, Søren, and WAGNER, Philippe
- Subjects
STATISTICS ,EXPERIMENTAL design ,PUBLISHING ,REPORT writing ,MEDICAL protocols ,DATA analysis ,NEWSLETTERS ,MEDICAL research ,AUTHORSHIP - Abstract
The article focuses on providing guidelines for authors to structure their manuscripts according to good statistical standards facilitating sound scientific work and making articles more accessible to readers. Topics include importance of planning statistical analyses during the study protocol stage, emphasizing the need for high-quality data and appropriate statistical knowledge for valid results, and addressing specific issues such as post hoc modification of research objectives.
- Published
- 2023
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31. Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review.
- Author
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Deckers, Claudia, Steyvers, Maarten J, Hannink, Gerjon, Schreuder, H W Bart, de Rooy, Jacky W J, and Van Der Geest, Ingrid C M
- Subjects
BONE tumors ,MEDICAL information storage & retrieval systems ,MAGNETIC resonance imaging ,MEDLINE ,META-analysis ,ONLINE information services ,QUALITY assurance ,SYSTEMATIC reviews ,CHONDROSARCOMA ,TUMOR grading - Abstract
Background and purpose — Adequate staging of chondroid tumors at diagnosis is important as it determines both treatment and outcome. This systematic review provides an overview of MRI criteria used to differentiate between atypical cartilaginous tumors (ACT) and high-grade chondrosarcoma (HGCS). Patients and methods — For this systematic review PubMed and Embase were searched, from inception of the databases to July 12, 2018. All original articles describing MRI characteristics of pathologically proven primary central chondrosarcoma and ACT were included. A quality appraisal of the included papers was performed. Data on MRI characteristics and histological grade were extracted by 2 reviewers. Meta-analysis was performed if possible. The study is registered with PROSPERO, CRD42018067959. Results — Our search identified 2,132 unique records, of which 14 studies were included. 239 ACT and 140 HGCS were identified. The quality assessment showed great variability in consensus criteria used for both pathologic and radiologic diagnosis. Due to substantial heterogeneity we refrained from pooling the results in a meta-analysis and reported non-statistical syntheses. Loss of entrapped fatty marrow, cortical breakthrough, and extraosseous soft tissue expansion appeared to be present more often in HGCS compared with ACT. Interpretation — This systematic review provides an overview of MRI characteristics used to differentiate between ACT and HGCS. Future studies are needed to develop and assess more reliable imaging methods and/or features to differentiate ACT from HGCS. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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- View/download PDF
32. Rates of knee arthroplasty in anterior cruciate ligament reconstructed patients: a longitudinal cohort study of 111,212 procedures over 20 years.
- Author
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Abram, Simon G F, Judge, Andrew, Khan, Tanvir, Beard, David J, and Price, Andrew J
- Subjects
ANTERIOR cruciate ligament surgery ,CONFIDENCE intervals ,DECISION making ,LONGITUDINAL method ,RISK assessment ,SURVIVAL analysis (Biometry) ,TOTAL knee replacement ,PROPORTIONAL hazards models ,ODDS ratio - Abstract
Background and purpose — Long-term rates of knee arthroplasty in patients with anterior cruciate ligament (ACL) injury who undergo ligament reconstruction (ACLr) are unclear. We determined this risk of arthroplasty through comparison with the general population. Patients and methods — All patients undergoing an ACLr in England, 1997–2017, were identified from national hospital statistics. Patients subsequently undergoing a knee arthroplasty were identified and survival analysis was performed (survival without undergoing knee arthroplasty). A Cox proportional hazards model was used to identify factors associated with knee arthroplasty. Relative risk of knee arthroplasty (total or partial) in comparison with the general population was determined. Results — 111,212 ACLr patients were eligible for analysis (mean age 29; 77% male). Overall, 0.46% (95% confidence interval [CI] 0.40–0.52) ACLr patients underwent knee arthroplasty within 5 years, 0.97% (CI 0.82–1.2) within 10 years, and 1.8% (CI 1.4–2.3) within 15 years. Knee arthroplasty risk was greater in older age groups and women. In comparison with the general population, the relative risk of undergoing arthroplasty at a younger age (at time of arthroplasty) was elevated: at 30–39 years (risk ratio [RR] 20; CI 11–35), 40–49 years (RR 7.5; CI 5.5–10), and 50–59 years (RR 2.5; CI 1.8–3.5), but not 60–69 years (RR 1.7; CI 0.93–3.2). Interpretation — Patients sustaining an ACL injury who undergo ACLr are at elevated risk of subsequent knee arthroplasty in comparison with the general population. Although the absolute rate of arthroplasty is low, the risk of arthroplasty at a younger age is particularly elevated. When the outcome of shared decision-making is ACLr, this data will help inform patients and clinicians about the long-term risk of requiring knee arthroplasty. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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33. Outcome of the cementless Taperloc stem.
- Author
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McLaughlin, Jeffrey R. and Labek, Gerold
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- 2011
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34. Patient-reported outcome measures in arthroplasty registries.
- Author
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Rolfson, Ola, Bohm, Eric, Franklin, Patricia, Lyman, Stephen, Denissen, Geke, Dawson, Jill, Dunn, Jennifer, Eresian Chenok, Kate, Dunbar, Michael, Overgaard, Søren, Garellick, Göran, and Lübbeke, Anne
- Subjects
REPORTING of diseases ,DOCUMENTATION ,EVALUATION of medical care ,HEALTH outcome assessment ,PATIENT satisfaction ,TOTAL hip replacement ,TOTAL knee replacement ,PAIN measurement - Abstract
Abstract — The International Society of Arthroplasty Registries (ISAR) Patient-Reported Outcome Measures (PROMs) Working Group have evaluated and recommended best practices in the selection, administration, and interpretation of PROMs for hip and knee arthroplasty registries. The 2 generic PROMs in common use are the Short Form health surveys (SF-36 or SF-12) and EuroQol 5-dimension (EQ-5D). The Working Group recommends that registries should choose specific PROMs that have been appropriately developed with good measurement properties for arthroplasty patients. The Working Group recommend the use of a 1-item pain question (“During the past 4 weeks, how would you describe the pain you usually have in your [right/left] [hip/knee]?”; response: none, very mild, mild, moderate, or severe) and a single-item satisfaction outcome (“How satisfied are you with your [right/left] [hip/knee] replacement?”; response: very unsatisfied, dissatisfied, neutral, satisfied, or very satisfied). Survey logistics include patient instructions, paper- and electronic-based data collection, reminders for follow-up, centralized as opposed to hospital-based follow-up, sample size, patient- or joint-specific evaluation, collection intervals, frequency of response, missing values, and factors in establishing a PROMs registry program. The Working Group recommends including age, sex, diagnosis at joint, general health status preoperatively, and joint pain and function score in case-mix adjustment models. Interpretation and statistical analysis should consider the absolute level of pain, function, and general health status as well as improvement, missing data, approaches to analysis and case-mix adjustment, minimal clinically important difference, and minimal detectable change. The Working Group recommends data collection immediately before and 1 year after surgery, a threshold of 60% for acceptable frequency of response, documentation of non-responders, and documentation of incomplete or missing data. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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35. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures.
- Author
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Johansson, Torsten
- Subjects
CALLUS ,BONE fractures ,HUMERUS injuries ,PAIN measurement ,RANDOMIZED controlled trials ,VISUAL analog scale ,POSTMENOPAUSE ,FRACTURE healing ,TERIPARATIDE ,THERAPEUTICS - Abstract
Background and purpose —There is solid evidence from animal experiments that parathyroid hormone (PTH) improves fracture healing. So far, only 3 papers on PTH and fracture repair in humans have been published. They suggest that PTH may enhance fracture healing, but the results do not appear to justify specific clinical recommendations. This study was carried out to determine whether teriparatide enhances fracture healing of proximal humerus fractures. Patients and methods —40 post-menopausal women with a proximal humerus fracture were randomized to either daily injections with 20 µg teriparatide (PTH 1-34 (Forteo)) for 4 weeks or control treatment. At randomization, the patients were asked to assess how their pain at rest and during activity (visual analog scale (VAS)) and also function (DASH score) had been prior to the fracture. At 7 weeks and again at 3 months, their current state was assessed and the tests were repeated, including radiographs. 2 radiologists performed a blind qualitative scoring of the callus at 7 weeks. Callus formation was arbitrarily classified as ”normal” or “better”. Results —39 patients completed the follow-up. The radiographic assessment showed a correct correlation, “better” in the teriparatide group and “normal” in the control group, in 21 of the 39 cases. There were no statistically significant differences in pain, in use of strong analgesics, or in function between the groups at the follow-up examinations. Interpretation —There were no radiographic signs of enhanced healing or improved clinical results in the group treated with teriparatide [ABSTRACT FROM AUTHOR]
- Published
- 2016
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36. The rise of registry-based research: a bibliometric analysis
- Author
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Emilio Romanini, Irene Schettini, Marina Torre, Michele Venosa, Alessio Tarantino, Vittorio Calvisi, and Gustavo Zanoli
- Subjects
Orthopedic surgery ,RD701-811 - Abstract
Background and purpose — The main purpose of arthroplasty registries is to collect information on patients, techniques, and devices to monitor and improve the outcome of the specific procedure. This study analyses the role played by registries in the orthopedic research community and describes publication trends, characteristics, and patterns of this field of research. Patients and methods — A descriptive-bibliometric review was conducted. Scopus was the database used for the research. All articles published from 1991 to December 2020 containing keywords related to registries and arthroplasty were considered. In particular, the following dimensions were analyzed in detail: (i) papers/year; (ii) journals; (iii) countries; (iv) research growth rate; (v) collaboration among countries. VOSviewer software was used to perform the bibliometric analysis. Finally, the 50 most cited papers of the last 10 years were briefly analyzed. Results — 3,933 articles were identified. There has been growing interest in the topic since 2010. Acta Orthopaedica ranked first for the number of articles published. The country with the largest number of articles citing registries was the United States, followed by the United Kingdom and Sweden. The relative number of articles per 100,000 inhabitants is 0.60 for Europe and 0.38 for the United States. The literature in this research area has an average yearly growth rate of 28%. Interpretation — The publication rate in the field of arthroplasty registries is constantly growing with a noteworthy impact in the evolution of this research and clinical area. The growth rate is significantly higher than that of arthroplasty literature (28% vs. 10%) and the collaboration among countries is strong and increasing with time.
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- 2021
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37. How many shoulder fractures are displaced? How a misleading statement became orthopedic knowledge.
- Author
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BRORSON, Stig
- Subjects
JOINT dislocations ,SHOULDER joint injuries ,HEALTH literacy ,ORTHOPEDICS ,DECISION making in clinical medicine ,BONE fractures ,DECEPTION ,SARCOMA ,EPIDEMIOLOGICAL research - Abstract
The article focuses on the importance of accurate prevalence knowledge in clinical decision-making, emphasizing the potential cognitive bias and errors that may arise from over- or underestimating the prevalence of clinical phenomena. Topics include the sources of knowledge on prevalence, the fundamental classification of proximal humeral fractures into minimally displaced and displaced categories, and the misleading statement regarding the prevalence of minimally displaced fractures.
- Published
- 2023
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38. Determinants of outcome in lumbar spinal stenosis surgery.
- Author
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Sigmundsson, Freyr Gauti
- Subjects
LUMBAR vertebrae surgery ,PAIN ,ORTHOPEDIC surgery ,ACADEMIC medical centers ,CHI-squared test ,CONFIDENCE intervals ,STATISTICAL correlation ,ACADEMIC dissertations ,HEALTH surveys ,LONGITUDINAL method ,LUMBAR vertebrae ,MAGNETIC resonance imaging ,PATIENT satisfaction ,QUALITY of life ,QUESTIONNAIRES ,SPINAL stenosis ,STATISTICS ,DATA analysis ,MULTIPLE regression analysis ,VISUAL analog scale ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DATA analysis software ,DESCRIPTIVE statistics ,MANN Whitney U Test - Abstract
The article presents a college thesis which investigated the determinants of the outcomes of lumbar spinal stenosis surgery and is based on several papers previously published by F. G. Sigmundsson, B. Jönsson and B.Strömqvist, including papers which appeared in a 2013 issue of "Acta Orthopaedica", a 2012 issue of "Acta Orthopaedica" and a 2014 issue of "Spine".
- Published
- 2014
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39. Long-term outcomes of over 8,000 medial Oxford Phase 3 Unicompartmental Knees-a systematic review.
- Author
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Mohammad, Hasan R, Strickland, Louise, Hamilton, Thomas W, and Murray, David W
- Subjects
ARTHROPLASTY ,CONFIDENCE intervals ,KNEE surgery ,PAIN ,COMPLICATIONS of prosthesis ,PUBLISHING ,REOPERATION ,SURGEONS ,SURVIVAL analysis (Biometry) ,SYSTEMATIC reviews ,TREATMENT effectiveness ,DISEASE progression - Abstract
Background and purpose - There is debate as to the relative merits of unicompartmental and total knee arthroplasty (UKA, TKA). Although the designer surgeons have achieved good results with the Oxford UKA there is concern over the reproducibility of these outcomes. Therefore, we evaluated published long-term outcomes of the Oxford Phase 3 UKA. Patients and methods - We searched databases to identify studies reporting ≥10 year outcomes of the medial Oxford Phase 3 UKA. Revision, non-revision, and re-operation rates were calculated per 100 component years (% pa). Results - 15 studies with 8,658 knees were included. The annual revision rate was 0.74% pa (95% CI 0.67--0.81, n = 8,406) corresponding to a 10-year survival of 93% and 15-year survival of 89%. The non-revision re-operation rate was 0.19% pa (95% CI 0.13--0.25, n = 3,482). The re-operation rate was 0.89% pa (95% CI 0.77--1.02, n = 3,482). The most common causes of revision were lateral disease progression (1.42%), aseptic loosening (1.25%), bearing dislocation (0.58%), and pain (0.57%) (n = 8,658). Average OKS scores were 40 at 10 years (n = 3,417). The incidence of medical complications was 0.83% (n = 1,443). Interpretation - Very good outcomes were achieved by both designer and non-designer surgeons. The PROMs, medical complication rate, and non-revision re-operation rate were better than those found in meta-analyses and publications for TKA but the revision rate was higher. However, if failure is considered to be all re-operations and not just revisions, then the failure rate of UKA was less than that of TKA. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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40. Hope for better days: 2 studies aiming to answer the remaining questions around dual mobility cups.
- Author
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Verhaar, Jan
- Subjects
PREVENTION of surgical complications ,HIP joint dislocation ,PROSTHETICS ,SERIAL publications ,TOTAL hip replacement - Abstract
An editorial is presented on studies aiming to answer the remaining questions around dual mobility cups. Topics include the dual mobility cups (DMCs) came onto the market to reduce the risk of dislocation after total hip arthroplasty, and the spherical liner in a DMC encloses the metal femoral head and articulates with a thin metal shell which is fixed to the acetabular bone.
- Published
- 2020
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41. Bone grafting: historical and conceptual review, starting with an old manuscript by Vittorio Putti.
- Author
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Donati, Davide, Zolezzi, Carola, Tomba, Patrizia, and Viganò, Anna
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BONE grafting ,ORTHOPEDICS ,BONE surgery ,HISTORY of surgery - Abstract
Vittorio Putti has been recognized as one of the founders of orthopedic science. He wrote a number of original papers on different topics from his vast experience of orthopedics. In a paper on bone grafting dated 1912, Putti demonstrated his modern way of thinking by his ability to study past experiences critically and by his willingness to compare his own experiences with those of other orthopedic surgeons. Putti's paper proposes principles that still apply today, and which can be considered as the basis of the modern science of grafting. The results of his work can be summarized as follows: a) The uniformity of bone graft integration processes, and a marked reduction in integration capacity in heteroplastic grafts. b) The osteogenetic incapability of the graft as opposed to the osteogenetic capability of the periosteum. c) Marked reduction in the biological capability of bone that has been treated with preservatives, boiled, or macerated. d) The importance of the quality of the tissues in which the bone graft is inserted, including the mechanical characteristics of the graft and its fixation. e) The importance of asepsis. f) The importance of functional exercise. These important experiences were achieved without Putti having any knowledge of immunology, vascular surgery, tissue preservation or non decalcified histology techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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42. Postoperative mortality after a hip fracture over a 15-year period in Denmark: a national register study.
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FRACTURE fixation ,BONE fractures ,HIP joint injuries ,POSTOPERATIVE period ,RISK assessment ,TOTAL hip replacement ,HEMIARTHROPLASTY - Published
- 2020
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43. Methods.
- Author
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Young, Sven
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INFECTION risk factors ,HIV infection complications ,POVERTY areas ,DATABASES ,FEMUR injuries ,BONE fractures ,MEDICAL information storage & retrieval systems ,SURGICAL complications - Abstract
In this article the authors discuss methods which they used during research on intramedullary nailing in fracture fixation in low and middle income countries (LIMC) with assistance from the Surgical Implant Generation Network and which is featured in three articles which are abstracted and discussed within the issue. In the article they offer opinions on points raised in their research and on the challenges of surgery and conducting research in LIMC.
- Published
- 2014
44. Increased risk of intraoperative and early postoperative periprosthetic femoral fracture with uncemented stems.
- Author
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Lindberg-Larsen, Martin, Jørgensen, Christoffer C, Solgaard, Søren, Kjersgaard, Anne G, and Kehlet, Henrik
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FEMUR injuries ,FRACTURE fixation ,BONE fractures ,OSTEOPOROSIS ,REGRESSION analysis ,TOTAL hip replacement ,DISEASE incidence - Abstract
Background and purpose — The use of uncemented fixation in total hip arthroplasty (THA) is increasing. Registry studies have indicated an increased risk of revision of uncemented implants due to early periprosthetic femoral fracture. In this paper, we describe the incidence and predisposing factors for intraoperative and early postoperative (≤90 days) periprosthetic femoral fractures after cemented and uncemented THA. Patients and methods — This was a prospective observational study in 8 Danish high-volume centers from February 2010 to November 2013. We used the 90-day follow-up from the Danish National Patient Registry and patient records. We obtained intraoperative information from the Danish Hip Arthroplasty Registry and from surgical notes. Results — Of 7,169 primary consecutive THAs, 5,482 (77%) were performed using uncemented femoral components. The total incidence of periprosthetic femoral fractures≤90 days postoperatively was 2.1% (n = 150). 70 fractures were detected intraoperatively (46 required osteosynthesis). 51 postoperatively detected fractures occurred without trauma (42 of which were reoperated) and 29 were postoperative fall-related fractures (27 of which were reoperated). 134 fractures (2.4%) were found in uncemented femoral components and 16 (0.9%) were found in cemented femoral components (p < 0.001). Uncemented femoral stem (relative risk (RR) = 4.1, 95% CI: 2.3–7.2), medically treated osteoporosis (RR =2.8, CI: 1.6–4.8), female sex (RR =1.6, CI: 1.1–2.2), and age (RR =1.4 per 10 years, CI: 1.2–1.6) were associated with increased risk of periprosthetic femoral fracture when analyzed using multivariable regression analysis. Interpretation — Uncemented femoral components were associated with an increased risk of early periprosthetic femoral fractures, especially in elderly, female, and osteoporotic patients. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
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45. Effect of platelet-rich plasma on rat Achilles tendon healing is related to microbiota.
- Author
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Dietrich, Franciele, Hammerman, Malin, Blomgran, Parmis, Tätting, Love, Bampi, Vinicius Faccin, Silva, Jefferson Braga, and Aspenberg, Per
- Subjects
ACHILLES tendon ,BIOLOGICAL models ,HUMAN microbiota ,INFLAMMATION ,RATS ,STAPHYLOCOCCUS aureus ,T cells ,WOUND healing ,PLATELET-rich plasma - Abstract
Background and purpose — In 3 papers in Acta Orthopaedica 10 years ago, we described that platelet-rich plasma (PRP) improves tendon healing in a rat Achilles transection model. Later, we found that microtrauma has similar effects, probably acting via inflammation. This raised the suspicion that the effect ascribed to growth factors within PRP could instead be due to unspecific influences on inflammation. While testing this hypothesis, we noted that the effect seemed to be related to the microbiota. Material and methods — We tried to reproduce our old findings with local injection of PRP 6 h after tendon transection, followed by mechanical testing after 11 days. This failed. After fruitless variations in PRP production protocols, leukocyte concentration, and physical activity, we finally tried rats carrying potentially pathogenic bacteria. In all, 242 rats were used. Results — In 4 consecutive experiments on pathogen-free rats, no effect of PRP on healing was found. In contrast, apparently healthy rats carrying Staphylococcus aureus showed increased strength of the healing tendon after PRP treatment. These rats had higher levels of cytotoxic T-cells in their spleens. Interpretation — The failure to reproduce older experiments in clean rats was striking, and the difference in response between these and Staphylococcus-carrying rats suggests that the PRP effect is dependent on the immune status. PRP functions may be more complex than just the release of growth factors. Extrapolation from our previous findings with PRP to the situation in humans therefore becomes even more uncertain. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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46. Reverse hybrid total hip arthroplasty.
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Wangen, Helge, Havelin, Leif I, Fenstad, Anne M, Hallan, Geir, Furnes, Ove, Pedersen, Alma B, Overgaard, Søren, Kärrholm, Johan, Garellick, Göran, Mäkelä, Keijo, Eskelinen, Antti, and Nordsletten, Lars
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DIAGNOSIS of bone fractures ,COMPARATIVE studies ,CONFIDENCE intervals ,BONE fractures ,FEMUR injuries ,REOPERATION ,TOTAL hip replacement ,RELATIVE medical risk ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,DIAGNOSIS - Abstract
Background and purpose — The use of a cemented cup together with an uncemented stem in total hip arthroplasty (THA) has become popular in Norway and Sweden during the last decade. The results of this prosthetic concept, reverse hybrid THA, have been sparsely described. The Nordic Arthroplasty Register Association (NARA) has already published 2 papers describing results of reverse hybrid THAs in different age groups. Based on data collected over 2 additional years, we wanted to perform in depth analyses of not only the reverse hybrid concept but also of the different cup/stem combinations used. Patients and methods — From the NARA, we extracted data on reverse hybrid THAs from January 1, 2000 until December 31, 2013. 38,415 such hips were studied and compared with cemented THAs. The Kaplan-Meier method and Cox regression analyses were used to estimate the prosthesis survival and the relative risk of revision. The main endpoint was revision for any reason. We also performed specific analyses regarding the different reasons for revision and analyses regarding the cup/stem combinations used in more than 500 cases. Results — We found a higher rate of revision for reverse hybrids than for cemented THAs, with an adjusted relative risk of revision (RR) of 1.4 (95% CI: 1.3–1.5). At 10 years, the survival rate was 94% (CI: 94–95) for cemented THAs and 92% (95% CI: 92–93) for reverse hybrids. The results for the reverse hybrid THAs were inferior to those for cemented THAs in patients aged 55 years or more (RR =1.1, CI: 1.0–1.3; p < 0.05). We found a higher rate of early revision due to periprosthetic femoral fracture for reverse hybrids than for cemented THAs in patients aged 55 years or more (RR =3.1, CI: 2.2–4.5; p < 0.001). Interpretation — Reverse hybrid THAs had a slightly higher rate of revision than cemented THAs in patients aged 55 or more. The difference in survival was mainly caused by a higher incidence of early revision due to periprosthetic femoral fracture in the reversed hybrid THAs. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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47. Aarhus Regenerative Orthopaedics Symposium (AROS).
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Foldager, Casper B, Bendtsen, Michael, Berg, Lise C, Brinchmann, Jan E, Brittberg, Mats, Bunger, Cody, Canseco, Jose, Chen, Li, Christensen, Bjørn B, Colombier, Pauline, Deleuran, Bent W, Edwards, James, Elmengaard, Brian, Farr, Jack, Gatenholm, Birgitta, Gomoll, Andreas H, Hui, James H, Jakobsen, Rune B, Joergensen, Natasja L, and Kassem, Moustapha
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OLDER people ,AGING ,BIOLOGICAL models ,CONFERENCES & conventions ,NONSTEROIDAL anti-inflammatory agents ,ORTHOPEDICS ,HEALTH outcome assessment ,REGENERATION (Biology) ,COMORBIDITY ,POLYPHARMACY - Abstract
The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often accompanied by decline in quality of life due to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers. In this position paper, we review our contemporary understanding of societal, patient-related, and basic science-related challenges in order to provide a reasoned roadmap for the future to deal with this compelling and urgent healthcare problem. [ABSTRACT FROM PUBLISHER]
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- 2016
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48. Good results at 2-year follow-up of a custom-made triflange acetabular component for large acetabular defects and pelvic discontinuity: a prospective case series of 50 hips.
- Author
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Scharff-Baauw, Marieke, Van Hooff, Miranda L, Van Hellemondt, Gijs G, Jutte, Paul C, Bulstra, Sjoerd K, and Spruit, Maarten
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ACETABULUM surgery ,TOTAL hip replacement ,CLINICAL trials ,FUNCTIONAL status ,BONE screws ,HEALTH outcome assessment ,SURGICAL complications ,TREATMENT effectiveness ,REOPERATION ,CASE studies ,DESCRIPTIVE statistics ,ACETABULUM (Anatomy) ,LONGITUDINAL method - Abstract
Background and purpose — Custom triflange acetabular components (CTACs) are suggested as good solutions for large acetabular defects in revision total hip arthroplasty. However, high complication rates have been reported and most studies are of limited quality. This prospective study evaluates the performance of a CTAC in patients with large acetabular defects including pelvic discontinuity. Patients and methods — Prospectively collected data of 49 consecutive patients (50 hips), who underwent an acetabular revision with a CTAC were analyzed. Follow-up (FU) was 2 years. The median age of the patients was 68 years (41–89) and 41 were women. Primary outcomes were re-revision of the CTAC and differences between the modified Oxford Hip Score (mOHS) preoperatively and at 2-year follow-up. Secondary outcomes included several patient-reported outcomes (PROMs), radiological results, complications, and a comparison between hips with and without pelvic discontinuity (PD). Results — 1 patient (1 hip) was lost to the 2-year FU. No CTAC needed re-revision. The preoperative and 2-year FU mOHS were available in 40 hips and improved statistically significantly. All of the other secondary outcomes improved over time. 5 hips (of 45 with radiological 2-year FU) had loosening of screws. 8 hips had complications, including 3 persistent wound leakage, 3 pelvic fractures, and 1 dislocation. The mOHS and complication rate were similar in hips with and without PD. Interpretation — Reconstruction of large acetabular defects with and without PD with this CTAC showed good improvement in patient-reported daily functioning, high patient-reported satisfaction, few complications, and no re-revisions at 2-year FU. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
49. Emotional tones in scientific writing: comparison of commercially funded studies and non-commercially funded orthopedic studies.
- Author
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Steffens, Anath N V, Langerhuizen, David W G, Doornberg, Job N, Ring, David, and Janssen, Stein J
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ABSTRACTING ,ONLINE information services ,EXPERIMENTAL design ,SERIAL publications ,SYSTEMATIC reviews ,FEAR ,ENDOWMENT of research ,DESCRIPTIVE statistics ,ORTHOPEDICS ,MEDICAL writing ,EMOTIONS ,MEDLINE ,ANGER ,SADNESS - Abstract
Background and purpose — There is ongoing debate as to whether commercial funding influences reporting of medical studies. We asked: Is there a difference in reported tones between abstracts, introductions, and discussions of orthopedic journal studies that were commercially funded and those that were not commercially funded? Methods — We conducted a systematic PubMed search to identify commercially funded studies published in 20 orthopedic journals between January 1, 2000 and December 1, 2019. We identified commercial funding of studies by including in our search the names of 10 medical device companies with the largest revenue in 2019. Commercial funding was designated when either the study or 1 or more of the authors received funding from a medical device company directly related to the content of the study. We matched 138 commercially funded articles 1 to 1 with 138 non-commercially funded articles with the same study design, published in the same journal, within a time range of 5 years. The IBM Watson Tone Analyzer was used to determine emotional tones (anger, fear, joy, and sadness) and language style (analytical, confident, and tentative). Results — For abstract and introduction sections, we found no differences in reported tones between commercially funded and non-commercially funded studies. Fear tones (non-commercially funded studies 5.1%, commercially funded studies 0.7%, p = 0.04), and analytical tones (non-commercially funded studies 95%, commercially funded studies 88%, p = 0.03) were more common in discussions of studies that were not commercially funded. Interpretation — Commercially funded studies have comparable tones to non-commercially funded studies in the abstract and introduction. In contrast, the discussion of non-commercially funded studies demonstrated more fear and analytical tones, suggesting them to be more tentative, accepting of uncertainty, and dispassionate. As text analysis tools become more sophisticated and mainstream, it might help to discern commercial bias in scientific reports. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
50. Treatment of prosthetic joint infections due to Propionibacterium.
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CLINDAMYCIN ,RIFAMPIN ,PENICILLIN ,LINEZOLID ,DISEASE susceptibility ,INFECTION ,INTRAVENOUS therapy ,PROPIONIBACTERIUM ,COMPLICATIONS of prosthesis ,STAPHYLOCOCCAL diseases ,TREATMENT duration ,THERAPEUTICS - Abstract
A letter to the editor is presented in response to article "Treatment of prosthetic joint infections due to Propionibacterium" by A.M. Jacobs and others which appeared in a 2015 issue of journal.
- Published
- 2016
- Full Text
- View/download PDF
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