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Start Over Author "Lightwood, Daniel" Journal acta neuropathologica
3 results on '"Lightwood, Daniel"'

1. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity

Author

Gittings, Lauren M., primary, Boeynaems, Steven, additional, Lightwood, Daniel, additional, Clargo, Alison, additional, Topia, Sarfaraj, additional, Nakayama, Lisa, additional, Troakes, Claire, additional, Mann, David M. A., additional, Gitler, Aaron D., additional, Lashley, Tammaryn, additional, and Isaacs, Adrian M., additional

Published
2019
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2. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

Author

Gittings, Lauren M., Boeynaems, Steven, Lightwood, Daniel, Clargo, Alison, Topia, Sarfaraj, Nakayama, Lisa, Troakes, Claire, Mann, David M. A., Gitler, Aaron D., Lashley, Tammaryn, and Isaacs, Adrian M.

Subjects
DISEASE duration, PHASE separation, AMYOTROPHIC lateral sclerosis
Abstract

A GGGGCC repeat expansion in I C9orf72 i is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Therefore, in order to investigate DPR arginine methylation in I C9orf72 i FTD/ALS we generated and characterised two novel antibodies that detect the two forms of dimethylated poly-GR (Supplementary Fig. In summary, our data show that arginine methylation is a common post-translation modification of poly-GR in I C9orf72 i patient brain that may influence disease course. [Extracted from the article]

Published
2020
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3. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

Author

Courade, Jean-Philippe, primary, Angers, Rachel, additional, Mairet-Coello, Georges, additional, Pacico, Nathalie, additional, Tyson, Kerry, additional, Lightwood, Daniel, additional, Munro, Rebecca, additional, McMillan, David, additional, Griffin, Robert, additional, Baker, Terry, additional, Starkie, Dale, additional, Nan, Ruodan, additional, Westwood, Marta, additional, Mushikiwabo, Marie-Laetitia, additional, Jung, Sophie, additional, Odede, Geofrey, additional, Sweeney, Berni, additional, Popplewell, Andrew, additional, Burgess, Gillian, additional, Downey, Patrick, additional, and Citron, Martin, additional

Published
2018
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