Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

A GGGGCC repeat expansion in I C9orf72 i is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Therefore, in order to investigate DPR arginine methylation in I C9orf72 i FTD/ALS we generated and characterised two novel antibodies that detect the two forms of dimethylated poly-GR (Supplementary Fig. In summary, our data show that arginine methylation is a common post-translation modification of poly-GR in I C9orf72 i patient brain that may influence disease course. [Extracted from the article]