43 results on '"Sundaram, Rajeshwari"'
Search Results
2. Place-Based Child Opportunity at Birth and Child Development from Infancy to Age 4.
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Putnick, Diane L., Bell, Erin M., Tyris, Jordan, McAdam, Jordan, Ghassabian, Akhgar, Mendola, Pauline, Sundaram, Rajeshwari, and Yeung, Edwina
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- 2024
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3. Longitudinal Child Growth Patterns in Twins and Singletons in the Upstate KIDS Cohort.
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Gleason, Jessica L., Yeung, Edwina H., Sundaram, Rajeshwari, Putnick, Diane L., Mendola, Pauline, Bell, Erin M., Polinski, Kristen J., Robinson, Sonia L., and Grantz, Katherine L.
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- 2023
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4. Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism
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Polinski, Kristen J., Robinson, Sonia L., Putnick, Diane L., Sundaram, Rajeshwari, Bell, Erin, Joseph, Paule V., Segars, James, Guan, Weihua, Silver, Robert M., Schisterman, Enrique F., Mumford, Sunni L., and Yeung, Edwina H.
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ABSTRACTResearch suggests that polycystic ovary syndrome (PCOS) traits (e.g., hyperandrogenism) may create a suboptimal intrauterine environment and induce epigenetic modifications. Therefore, we assessed the associations of PCOS traits with neonatal DNA methylation (DNAm) using two independent cohorts. DNAm was measured in both cohorts using the Infinium MethylationEPIC array. Multivariable robust linear regression was used to determine associations of maternal PCOS exposure or preconception testosterone with methylation β-values at each CpG probe and corrected for multiple testing by false-discovery rate (FDR). In the birth cohort, 12% (102/849) had a PCOS diagnosis (8.1% PCOS without hirsutism; 3.9% PCOS with hirsutism). Infants exposed to maternal PCOS with hirsutism compared to no PCOS had differential DNAm at cg02372539 [β(SE): −0.080 (0.010); FDR p = 0.009], cg08471713 [β(SE):0.077 (0.014); FDR p = 0.016] and cg17897916 [β(SE):0.050 (0.009); FDR p = 0.009] with adjustment for maternal characteristics including pre-pregnancy BMI. PCOS with hirsutism was also associated with 8 differentially methylated regions (DMRs). PCOS without hirsutism was not associated with individual CpGs. In an independent preconception cohort, total testosterone concentrations were associated with 3 DMRs but not with individual CpGs, though the top quartile of testosterone compared to the lowest was marginally associated with increased DNAm at cg21472377 near an uncharacterized locus (FDR p = 0.09). Examination of these probes and DMRs indicate they may be under foetal genetic control. Overall, we found several associations among newborns exposed to PCOS, specifically when hirsutism was reported, and among newborns of women with relatively higher testosterone around conception.
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- 2023
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5. Patterns and Variability of Endocrine-disrupting Chemicals During Pregnancy: Implications for Understanding the Exposome of Normal Pregnancy.
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Buck Louis, Germaine M., Yeung, Edwina, Kannan, Kurunthachalam, Maisog, Joseph, Zhang, Cuilin, Grantz, Katherine L., and Sundaram, Rajeshwari
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PREGNANCY ,POLLUTANTS ,DURATION of pregnancy ,REGRESSION analysis ,PREGNANCY outcomes ,RESEARCH funding ,COLLECTION & preservation of biological specimens ,ENVIRONMENTAL exposure ,ENDOCRINE disruptors - Abstract
Background: The exposome is a novel research paradigm offering promise for understanding the complexity of human exposures, including endocrine-disrupting chemicals (EDCs) and pregnancy outcomes. The physiologically active state of pregnancy requires understanding temporal changes in EDCs to better inform the application of the exposome research paradigm and serve as the impetus for study.Methods: We randomly selected 50 healthy pregnant women with uncomplicated pregnancies from a pregnancy cohort who had available serum/urine samples in each trimester for measuring 144 persistent and 48 nonpersistent EDCs. We used unsupervised machine-learning techniques capable of handling hierarchical clustering of exposures to identify EDC patterns across pregnancy, and linear mixed-effects modeling with false-discovery rate correction to identify those that change over pregnancy trimesters. We estimated the percent variation in chemical concentrations accounted for by time (pregnancy trimester) using Akaike Information Criterion-based R methods.Results: Four chemical clusters comprising 80 compounds, of which six consistently increased, 63 consistently decreased, and 11 reflected inconsistent patterns over pregnancy. Overall, concentrations tended to decrease over pregnancy for persistent EDCs; a reverse pattern was seen for many nonpersistent chemicals. Explained variance was highest for five persistent chemicals: polybrominated diphenyl ethers #191 (51%) and #126 (47%), hexachlorobenzene (46%), p,p'-dichloro-diphenyl-dichloroethylene (46%), and o,p'-dichloro-diphenyl-dichloroethane (36%).Conclusions: Concentrations of many EDCs are not stable across pregnancy and reflect varying patterns depending on their persistency underscoring the importance of timed biospecimen collection. Analytic techniques are available for assessing temporal patterns of EDCs during pregnancy apart from physiologic changes. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. Predicting the risk of cardiac myxoma in Carney complex
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Pitsava, Georgia, Zhu, Chunming, Sundaram, Rajeshwari, Mills, James L., and Stratakis, Constantine A.
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Carney complex (CNC), is an autosomal dominant multiple neoplasia and lentiginosis syndrome. We aimed to identify risk factors associated with the occurrence and recurrence of cardiac myxomas, the predominant cause of death in CNC patients.
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- 2021
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7. Association of Maternal Exposure to Persistent Organic Pollutants in Early Pregnancy With Fetal Growth
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Ouidir, Marion, Buck Louis, Germaine M., Kanner, Jenna, Grantz, Katherine L., Zhang, Cuilin, Sundaram, Rajeshwari, Rahman, Mohammad L., Lee, Sunmi, Kannan, Kurunthachalam, Tekola-Ayele, Fasil, and Mendola, Pauline
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IMPORTANCE: Prenatal exposure to persistent organic pollutants (POPs) has been associated with birth size, but data on fetal growth and among racially/ethnically diverse pregnant women remain scarce. OBJECTIVES: To assess the association between maternal plasma POPs in early pregnancy and fetal growth and by infant sex and maternal race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used the National Institute of Child Health and Human Development Fetal Growth Studies–Singleton cohort, which recruited nonobese, low-risk pregnant women before 14 weeks’ gestation between July 1, 2009, and January 31, 2013, in 12 community-based clinics throughout the United States. Participants self-identified their race/ethnicity, self-reported their behavioral risk factors, and were followed up throughout their pregnancy. Data were analyzed from July 31, 2018, to June 3, 2019. EXPOSURES: Levels of 76 POPs in early gestation plasma were measured: 11 perfluoroalkyl and polyfluoroalkyl substances, 1 polybrominated biphenyl, 9 polybrominated diphenyl ethers (PBDEs), 44 polychlorinated biphenyls (PCBs), and 11 organochlorine pesticides (OCPs). The bayesian kernel machine regression method was used to examine chemical class mixtures, and generalized additive mixed model was used to analyze individual chemicals. MAIN OUTCOMES AND MEASURES: Fourteen fetal biometrics were measured, including head circumference, abdominal circumference, and femur length, within 5 ultrasonography appointments. RESULTS: A total of 2284 low-risk pregnant women were included: 606 women (26.5%) self-identified as white with a mean (SD) age of 30.3 (4.4) years, 589 (25.8%) as black with a mean (SD) age of 25.5 (5.5) years, 635 (27.8%) as Hispanic with a mean (SD) age of 27.1 (5.5) years, and 454 (19.9%) as Asian with a mean (SD) age of 30.5 (4.5) years. A comparison between the 75th and 25th percentile of exposure revealed that the OCP mixture was negatively associated with most fetal growth measures, with a reduction of 4.7 mm (95% CI, −6.7 to −2.8 mm) in head circumference, 3.5 mm (95% CI, −4.7 to −2.2 mm) in abdominal circumference, and 0.6 mm (95% CI, −1.1 to −0.2 mm) in femur length. Higher exposure to the PBDE mixture was associated with reduced abdominal circumference (–2.4 mm; 95% CI, −4.0 to −0.5 mm) and femur length (−0.5 mm; 95% CI, −1.0 to −0.1 mm), and the dioxin-like PCB mixture was associated with reduced head circumference (–6.4 mm; 95% CI, −8.4 to −4.3 mm) and abdominal circumference (–2.4 mm; 95% CI, −3.9 to −0.8 mm). Associations with individual chemicals were less consistent. There were some interactions by fetal sex, although most of the results did not vary by maternal race/ethnicity. For example, oxychlordane (–0.98 mm; 95% CI, –1.60 to –0.36 mm; P for interaction <.001), trans-nonachlor (–0.31 mm; 95% CI, –0.54 to –0.08 mm; P for interaction = .005), and p,p’-dichlorodiphenyldichloroethylene (–0.19 mm; 95% CI, –0.22 to –0.09 mm; P for interaction = .006) were associated with shorter femur length among boys only. CONCLUSIONS AND RELEVANCE: This study found that, among pregnant women with low POP levels, a mixture of OCPs was negatively associated with most fetal growth measures and that mixtures of PBDEs and dioxin-like PCBs were associated with reduced abdominal circumference. These findings suggested that, although exposures may be low, associations with fetal growth are apparent.
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- 2020
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8. Association of Trajectory and Covariates of Children’s Screen Media Time
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Trinh, Mai-Han, Sundaram, Rajeshwari, Robinson, Sonia L., Lin, Tzu-Chun, Bell, Erin M., Ghassabian, Akhgar, and Yeung, Edwina H.
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IMPORTANCE: Many children begin interacting with screen media as early as infancy. Although screen time is associated with negative developmental consequences, few longitudinal studies in the United States have examined covariates of screen time among children under 3 years of age. OBJECTIVES: To identify trajectories of screen time among children aged 1 to 3 years, to examine their association with screen use at 8 years of age, and to assess potential determinants of screen time. DESIGN, SETTING, AND PARTICIPANTS: This prospective birth cohort study included 3895 children (3083 singletons and 812 unrelated multiples) in New York State who had screen time data available for at least 1 time point from 1 to 3 years of age; 1156 children had data at 8 years. The study spanned September 4, 2007, through June 12, 2014, in the first phase, and August 29, 2014, through November 15, 2019, in the second phase. Data analysis for the present study was conducted from September 28, 2018, to July 15, 2019. MAIN OUTCOMES AND MEASURES: Maternal reports of children’s television, movie, and computer game times were summed for total daily screen time at 12, 18, 24, 30, and 36 months of age. Two screen time trajectories (low and increasing use) were classified by cluster analysis, and logistic regression was used to model risk factors for the increasing trajectory. Children exhibiting the highest 10th percentile of screen use at each point were examined, and linear mixed models were used to identify risk factors of this high exposure category. RESULTS: Among the 3895 children included in the analysis (2031 boys [52.1%] and 1864 girls [47.9%]), median daily screen time increased from 30 (interquartile range, 0-60) minutes at 12 months of age to 120 (interquartile range, 75-200) minutes at 36 months of age. Of 1045 children with complete data at all 5 time points, 279 (26.7%) had an increasing screen time trajectory. Female child sex (adjusted odds ratio [aOR], 0.90; 95% CI, 0.81-0.99) and graduate school levels of paternal (aOR, 0.73; 95% CI, 0.56-0.95) and maternal (aOR, 0.60; 95% CI, 0.47-0.77) education, compared with having completed college, were associated with lower risk of increasing trajectory. Maternal nulliparity was associated with higher risk of increasing trajectory (aOR, 1.14; 95% CI, 1.00-1.30). Children with an increasing trajectory from 1 to 3 years of age had an additional 22 (95% CI, 11-33) minutes per day of screen time at 8 years of age. Covariates associated with the highest 10th percentile of screen exposure included paterman graduate school education compared with college (aOR, 0.63; 95% CI, 0.39-0.99), maternal graduate school education compared with college (aOR, 0.55; 95% CI, 0.37-0.82), maternal nulliparity (aOR, 1.98; 95% CI, 1.50-2.61), twins compared with singletons (aOR, 1.41; 95% CI, 1.05-1.91), non-Hispanic black compared with non-Hispanic white race/ethnicity (aOR, 4.77; 95% CI, 2.25-10.10), and type of care (home-based care aOR, 2.17 [95% CI, 1.38-3.41]; parental care aOR, 2.11 [95% CI, 1.41-3.15]) compared with center-based care. CONCLUSIONS AND RELEVANCE: These findings suggest that a range of parental and child characteristics are associated with screen time. Screen time habits appear to track from as early as infancy, emphasizing the need for earlier interventions.
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- 2020
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9. Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior.
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Ghassabian, Akhgar, Bell, Erin M., Ma, Wan-Li, Sundaram, Rajeshwari, Kannan, Kurunthachalam, Buck Louis, Germaine M., and Yeung, Edwina
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BISPHENOL A ,ENDOCRINE disruptors ,PERFLUOROOCTANOIC acid ,PERFLUOROOCTANE sulfonate ,TRANSMISSION electron microscopy - Abstract
Abstract Experimental studies suggest that prenatal exposure to endocrine disrupting chemicals interferes with developmental processes in the fetal brain. Yet, epidemiological evidence is inconclusive. In a birth cohort (2008–2010, upstate New York), we quantified concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) in stored newborn dried blood spots using liquid chromatography/tandem mass spectrometry. Mothers reported on children's behavior using the Strengths and Difficulties Questionnaire at age 7 (650 singletons and 138 twins). Difficulties in total behavior (i.e., emotional, conduct, hyperactivity, and peer problems) and prosocial behavior were classified using validated cut-offs. We used logistic regression with generalized estimating equations to estimate the odds of having difficulties per exposure category. In total, 111 children (12.1%) had total behavioral difficulties and 60 (6.5%) had difficulties in prosocial behavior. The median (interquartile range) of PFOS, PFOA, and BPA were 1.74 ng/ml (1.33), 1.12 ng/ml (0.96), and 7.93 ng/ml (10.79), respectively. Higher PFOS levels were associated with increased odds of having behavioral difficulties (OR per SD of log PFOS = 1.30, 95%CI: 1.03–1.65). We observed associations between PFOS in the highest relative to the lowest quartile and behavioral difficulties (OR for PFOS 1.14-1.74 = 1.65, 95%CI: 0.84–3.34; PFOS 1.75-2.47 = 1.73, 95%CI: 0.87–3.43; and PFOS >2.47 = 2.47, 95%CI: 1.29–4.72 compared to PFOS <1.41). The associations between higher concentrations of PFOS and behavioral difficulties at age 7 years were driven by problems in conduct and emotional symptoms. Higher PFOA levels were associated with difficulties in prosocial behavior (OR = 1.35, 95%CI: 1.03–1.75). There was an inverse association between BPA concentrations and difficulties in prosocial behavior but only in the 2nd and 4th quartiles. We found no interactions between sex and chemical concentrations. Increasing prenatal exposure to PFOS and PFOA, as reflected in neonatal concentrations, may pose risk for child behavioral difficulties. Graphical abstract Image 1 Highlights • We quantified concentrations of chemicals in newborn dried blood spots (DBS). • Higher PFOS levels were related to increased odds of behavioral difficulties. • Higher PFOA levels were associated with difficulties in prosocial behavior. • Newborn DBS can be used as a biospecimen for measurement of persistent chemicals. In children born between 2008 and 2010, we found that higher neonatal concentration of perfluorooctane sulfonate (PFOS) were associated with behavioral difficulties at age 7 years. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Perfluoroalkyl Chemicals, Menstrual Cycle Length, and Fecundity: Findings from a Prospective Pregnancy Study.
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Lum, Kirsten J., Sundaram, Rajeshwari, Barr, Dana B., Louis, Thomas A., and Buck Louis, Germaine M.
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BIRTH rate ,FATTY acids ,FERTILITY ,FLUOROCARBONS ,LIQUID chromatography ,LONGITUDINAL method ,MASS spectrometry ,MENSTRUAL cycle ,POLLUTANTS ,PROBABILITY theory ,RESEARCH funding ,SULFONAMIDES ,TIME ,SULFUR acids - Abstract
Background: Perfluoroalkyl substances have been associated with changes in menstrual cycle characteristics and fecundity, when modeled separately. However, these outcomes are biologically related, and we evaluate their joint association with exposure to perfluoroalkyl substances.Methods: We recruited 501 couples from Michigan and Texas in 2005-2009 upon their discontinuing contraception and followed them until pregnancy or 12 months of trying. Female partners provided a serum sample on enrollment and completed daily journals on menstruation, intercourse, and pregnancy test results. We measured seven perfluoroalkyl substances in serum using liquid chromatography-tandem mass spectrometry. We assessed the association between perfluoroalkyl substances and menstrual cycle length using accelerated failure time models and between perfluoroalkyl substances and fecundity using a Bayesian joint modeling approach to incorporate cycle length.Results: Menstrual cycles were 3% longer comparing women in the second versus first tertile of perfluorodecanoate (PFDeA; acceleration factor [AF] = 1.03, 95% credible interval [CrI] = [1.00, 1.05]), but 2% shorter for women in the highest versus lowest tertile of perfluorooctanoic acid (PFOA; AF = 0.98, 95% CrI = [0.96, 1.00]). When accounting for cycle length, relevant covariates, and remaining perfluoroalkyl substances, the probability of pregnancy was lower for women in second versus first tertile of perfluorononanoate (PFNA; odds ratio [OR] = 0.6, 95% CrI = [0.4, 1.0]) although not when comparing the highest versus lowest (OR = 0.7, 95% CrI = [0.3, 1.1]) tertile.Conclusions: In this prospective cohort study, we observed associations between two perfluoroalkyl substances and menstrual cycle length changes, and between select perfluoroalkyl substances and diminished fecundity at some (but not all) concentrations. See video abstract at, http://links.lww.com/EDE/B136. [ABSTRACT FROM AUTHOR]- Published
- 2017
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11. Comparing child growth between small-for-gestational age twins and singletons in the upstate KIDS cohort.
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Gleason, Jessica L., Yeung, Edwina, Sundaram, Rajeshwari, Mendola, Pauline, Bell, Erin, Polinski, Kristen, and Grantz, Katherine
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GROWTH of children ,AGE - Published
- 2023
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12. Seafood Intake, Sexual Activity, and Time to Pregnancy
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Gaskins, Audrey J, Sundaram, Rajeshwari, Buck Louis, Germaine M, and Chavarro, Jorge E
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In the present prospective cohort study with preconception enrollment and daily follow-up of couples, seafood intake in both partners was associated with a higher SIF and greater fecundity.
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- 2018
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13. Maternal polycystic ovarian syndrome and offspring growth: the Upstate KIDS Study
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Bell, Griffith A, Sundaram, Rajeshwari, Mumford, Sunni L, Park, Hyojun, Broadney, Miranda, Mills, James L, Bell, Erin M, and Yeung, Edwina H
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BackgroundPolycystic ovarian syndrome (PCOS) is the most common cause of female infertility and is associated with higher levels of circulating androgens. Exposure to higher levels of androgens in utero may be a risk factor for obesity among children of women with PCOS.MethodsWe examined whether maternal PCOS was associated with differences in offspring growth and obesity in the Upstate KIDS study, a prospective cohort study of infants born in New York State (excluding New York City) oversampled for fertility treatments and multiple births. Measurements of offspring length/height and weight were recorded at doctor’s visits through 3 years of age. PCOS diagnosis was self-reported by mothers at baseline. We used linear mixed models with robust SEs to estimate differences in growth by maternal PCOS exposure. We used logistic regression to examine whether infants experienced rapid weight gain at 4, 9 and 12 months. Growth measures were reported by 4098 mothers for 4949 children (1745 twins). Of these, 435 mothers (10.6%) had a diagnosis of PCOS.ResultsCompared with children born to mothers without PCOS, children of mothers with PCOS did not have significant differences in weight (4.81 g, 95% CI −95.1 to 104.7), length/height (0.18 cm, 95% CI −0.16 to 0.52) and body mass index (−0.14 kg/m2, 95% CI −0.30 to 0.01) through 3 years of age. We also observed no association between maternal PCOS and offspring rapid weight gain.ConclusionsOverall, we found little evidence to suggest that maternal PCOS influences early childhood growth in this large, prospective cohort study.
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- 2018
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14. Maternal caffeine consumption and child growth in the ECHO cohort of NICHD Fetal Growth Studies.
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Gleason, Jessica L., Sundaram, Rajeshwari, Mitro, Susanna D., Hinkle, Stefanie, Gilman, Stephen, Zhang, Cuilin, Newman, Roger, Hunt, Kelly, Robinson, Morgan, Kannan, Kurunthachalam, and Grantz, Katherine
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GROWTH of children ,FETAL development ,CAFFEINE - Published
- 2022
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15. Exposure to perfluoroalkyl substances and neonatal immunoglobulin profiles in the upstate KIDS study (2008–2010).
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Jones, Laura E., Ghassabian, Akhgar, Lawrence, David A., Sundaram, Rajeshwari, Yeung, Edwina, Kannan, Kurunthachalam, and Bell, Erin M.
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FLUOROALKYL compounds ,IMMUNOGLOBULIN E ,IMMUNOGLOBULIN M ,PERFLUOROOCTANE sulfonate ,RANDOM effects model ,BODY mass index - Abstract
Infant exposure to per/polyfluoroalkyl compounds is associated with immune disruption. We examined associations between neonatal concentrations of perflurooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) and immunoglobulin (Ig) isotype profiles in a prospective cohort of infants. We measured Ig isotypes, including IgA, IgE, IgM and the IgG subclasses IgG 1 , IgG 2 , IgG 3 , and IgG 4, and PFOA and PFOS in newborn dried bloodspots from N = 3175 infants in the Upstate KIDS Study (2008–2010). We examined the association between newborn Ig isotype levels and individual PFOS and PFOA concentrations using mixed effects regression models with a random intercept to account for twins among study participants. We assessed the joint effect PFOA and PFOS with quantile-based g-computation on all singletons and one randomly selected twin (N = 2901), with Ig categorized as above or below median value. Models were adjusted for infant sex, and maternal pre-pregnancy body mass index, race, parity, age and infertility treatment. In adjusted models, PFOA was inversely associated with IgE (coefficient = −0.12 per unit increase in PFOA, 95% CI: −0.065, −0.17), whereas IgG 2 , IgM, and IgA were positively associated with PFOA (coefficient for IgG 2 = 0.22, 95% CI: 0.15, 0.27; coefficient for IgM = 0.11, 95% CI: 0.08, 0.15; and coefficient for IgA = 0.15, 95% CI: 0.07, 0.18). There was no relation between PFOS and Ig isotypes. Analysis of the joint effect of PFOA and PFOS showed an OR of 1.2 (95% CI: 1.04, 1.36) for IgA and OR of 1.12 (95% CI: 1.00, 1.24) for IgG 2 levels above the median for every quartile increase. PFOA levels were significantly associated with elevated IgA, IgM, IgG 2 , and reduced levels of IgE in single-pollutant models. A small but significant joint effect of PFOA and PFOS was observed. Our results suggest that early exposure to PFOA and PFOS may disrupt neonatal immunoglobulin levels. [Display omitted] • Early exposure to PFOA and PFOS may disrupt neonatal immunoglobulin profiles. • PFOA was significantly associated with elevated IgA, IgM, IgG 2 and lower IgE levels. • Analysis yielded a significant joint effect consistent with single-pollutant models. • Effects of PFAS exposure on immunity are measurable even in newborns. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Perfluoroalkyl Chemicals, Menstrual Cycle Length, and Fecundity
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Lum, Kirsten J., Sundaram, Rajeshwari, Barr, Dana B., Louis, Thomas A., and Buck Louis, Germaine M.
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Supplemental Digital Content is available in the text.
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- 2017
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17. Maternal obesity, gestational weight gain, and offspring asthma and atopy.
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Polinski, Kristen J., Bell, Griffith A., Trinh, Mai-Han, Sundaram, Rajeshwari, Mendola, Pauline, Robinson, Sonia L., Bell, Erin M., Adeyeye, Temilayo, Lin, Tzu-Chun, and Yeung, Edwina H.
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- 2022
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18. Age of Juice Introduction and Child Anthropometry at 2-3 and 7-9 Years.
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Robinson, Sonia L., Sundaram, Rajeshwari, Lin, Tzu-Chun, Putnick, Diane L., Gleason, Jessica L., Ghassabian, Akhgar, Stevens, Danielle R., Bell, Erin M., and Yeung, Edwina H.
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Objectives: To assess the association between age of juice introduction and child anthropometry after the American Academy of Pediatrics changed their guidelines in 2017 to recommend delaying juice introduction until at least 12 months of age (previously 6 months), citing concerns of weight gain.Study Design: Upstate KIDS is a prospective birth cohort with follow-up through 9 years of age. Juice introduction was assessed on parental questionnaires at 4-18 months and categorized as <6, 6-<12, and ≥12 months. Child height and weight were recorded at 2-3 and 7-9 years of age. Weight-, height-, and body mass index (BMI)-for-age and sex z scores were calculated using the Centers for Disease Control and Prevention reference. Overweight/obese and obese status were categorized as BMI-for-age z score ≥85th and ≥95th percentiles. Controlling for sociodemographic characteristics and parental BMI, we assessed the associations of age of juice introduction with child anthropometry.Results: Prevalence of childhood obesity was 16.4% at 2-3 (n = 1713) and 22.8% at 7-9 years of age (n = 1283). Juice introduction at <6 vs ≥12 months was associated with higher weight-for-age z score at 2-3 years of age (mean difference = 0.21; 95% CI 0.04-0.37). At 7-9 years of age, juice introduction at <6 vs ≥12 months was related to higher BMI-for-age (0.38; 0.12-0.64) and weight-for-age z scores (0.27; 0.06-0.49). Risk of developing overweight/obesity and obesity was 1.54 (0.99-2.38) and 2.17 (1.11-4.23) times higher among children with juice introduced at <6 months. No associations were found with juice introduced at 6-<12 vs ≥12 months.Conclusions: Risk of developing overweight/obesity or obesity is higher among children introduced to juice before 6 months of age compared with ≥12 months. [ABSTRACT FROM AUTHOR]- Published
- 2022
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19. Adverse childhood experiences and premature mortality through mid-adulthood: A five-decade prospective study
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Yu, Jing, Patel, Reeya A., Haynie, Denise L., Vidal-Ribas, Pablo, Govender, Theemeshni, Sundaram, Rajeshwari, and Gilman, Stephen E.
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Adverse childhood experiences (ACEs) can have lasting effects on adult health and survival. In this study, we aimed to examine how the cumulative number and clustering patterns of ACEs were related to premature mortality.
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- 2022
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20. Feeding Problems as an Indicator of Developmental Delay in Early Childhood.
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Putnick, Diane L., Bell, Erin M., Ghassabian, Akhgar, Robinson, Sonia L., Sundaram, Rajeshwari, and Yeung, Edwina
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Objective: To determine whether feeding problems are indicators of developmental delay.Study Design: In this prospective longitudinal cohort study, mothers of 3597 children (49% female, 35% multiples) reported on their children's feeding problems and developmental delays (using the Ages and Stages Questionnaire [ASQ]) when children were age 18, 24, and 30 months. Average scores of feeding problems were computed at each age, as well as a categorical score indicating a persistently high number of feeding problems ≥90th percentile across time. The Battelle Developmental Inventory, Second Edition (BDI-2) was used to assess development in 5 domains for a subset of children at 4 years.Results: In adjusted analyses, feeding problems (per point increase) were increasingly associated with 6 ASQ domains from 18 months (OR, 1.30-1.98) to 24 months (OR, 2.07-2.69) to 30 months (OR, 3.90-5.64). Compared with children who never experienced feeding problems, children who experienced a high number of feeding problems at 1 or 2 time points were more than twice as likely to have a delay on all ASQ domains (OR, 2.10-2.50), and children who experienced a high number of feeding problems at all 3 time points were ≥4-fold more likely to have a delay on all ASQ domains (OR, 3.94-5.05). Children with 1-point higher feeding problems at 30 months scored 3-4 points lower in all BDI-2 domains at 4 years.Conclusions: Frequent feeding problems, especially those that persist into the third year, could be used to identify children at risk for developmental delay for more targeted screening. [ABSTRACT FROM AUTHOR]- Published
- 2022
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21. Examining Infertility Treatment and Early Childhood Development in the Upstate KIDS Study
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Yeung, Edwina H., Sundaram, Rajeshwari, Bell, Erin M., Druschel, Charlotte, Kus, Christopher, Ghassabian, Akhgar, Bello, Scott, Xie, Yunlong, and Buck Louis, Germaine M.
- Abstract
IMPORTANCE: An increasing percentage of births are conceived with assisted reproductive technology (ART) and other infertility treatment. Despite findings that such treatments may be associated with diminished gestation and birth size, scarce data exist regarding infertility treatments and children’s development in the United States. OBJECTIVE: To assess the use and type of infertility treatment in relation to children’s development through age 36 months. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study (conducted 2008-2014) that sampled based on infertility treatment and plurality. Included in the study were infants born between 2008 and 2010 in New York state (excluding New York City) whose parents completed developmental screening instruments through 36 months of age. A total of 4824 mothers (97% of 4989) completed 1 or more developmental screening instruments for 5841 children, including 1830 conceived with infertility treatment and 2074 twins. EXPOSURES: Maternal self-report of any infertility treatment was further categorized into ART and ovulation induction/intrauterine insemination. Assisted reproductive technology use was previously validated by linkage with the Society for Assisted Reproductive Technology–Clinical Outcome Reporting System. MAIN OUTCOMES AND MEASURES: Five developmental domains (fine motor, gross motor, communication, personal-social functioning, and problem-solving ability), as measured by the parental completion of the Ages and Stages Questionnaires at 4, 8, 12, 18, 24, 30, and 36 months of age. Generalized linear mixed modeling techniques estimated adjusted odds ratios (aORs) and 95% CIs for use and type of infertility treatment in relation to failing a developmental domain. Data were stratified by plurality and weighted for the sampling scheme. RESULTS: There were 1422 mothers (29.5%; mean [SD], age, 34.1 [5.2] years) who underwent infertility treatment. Infertility treatment was not associated with risk of their children failing any developmental domain (aOR, 1.33; 95% CI, 0.94-1.89). Assisted reproductive technology was associated with increased risk for failing any developmental domain but only when singletons and twins were evaluated together (aOR, 1.81; 95% CI, 1.21-2.72). Adjustment for birth weight further attenuated this estimate (aOR, 1.26; 95% CI, 0.82-1.93). After stratifying by plurality, type of treatment also was not significantly associated with failing any developmental domain for ovulation induction/intrauterine insemination (aOR, 1.00; 95% CI, 0.57-1.77 for singletons and aOR, 1.30; 95% CI, 0.76-2.21 for twins) or ART (aOR, 1.38; 95% CI, 0.78-2.43 for singletons and aOR, 1.58; 95% CI, 0.94-2.65 for twins). CONCLUSIONS AND RELEVANCE: After considering plurality, children’s development through age 3 years was similar irrespective of infertility treatment or specific type. To our knowledge, these findings are among the first to focus on non-ART treatments in the United States.
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- 2016
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22. Urinary Concentrations of Benzophenone-type UV Filters in U.S. Women and Their Association with Endometriosis.
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Kunisue, Tatsuya, Chen, Zhen, Louis, Germaine M. Buck, Sundaram, Rajeshwari, Hediger, Mary L., Sun, Liping, and Kannan, Kurunthachalam
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- 2012
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23. Validity of self-reported time to pregnancy.
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Cooney, Maureen A., Buck Louis, Germaine M., Sundaram, Rajeshwari, McGuiness, Bridget M., and Lynch, Courtney D.
- Abstract
Background: The reliability of retrospective time to pregnancy (TTP) has been established, but its validity has been assessed in only 1 study, which had a short follow-up.Methods: Ninety-nine women enrolled a decade earlier in a prospective TTP study were queried by means of mailed questionnaires about the duration of time they had required to become pregnant. Their responses were compared with their earlier data from daily diaries (gold standard).Results: One-third of women could not recall their earlier TTP either in menstrual cycles or calendar months. Only 17%-19% of women recalled their TTP exactly. Agreement increased to 41%-51%, 65%-72%, and 72%-77% when defined as +/-1, +/-2, and +/-3 months, respectively. Women with longer observed TTPs or previous pregnancies were more likely to under-report their TTP.Conclusions: The findings raise questions about the commonly assumed validity of self-reported TTP. Recalled TTP may introduce error when estimating fecundability or classifying couples' fecundity status. [ABSTRACT FROM AUTHOR]- Published
- 2009
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24. Maternal obesity, gestational weight gain and offspring asthma and atopy
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Polinski, Kristen J., Bell, Griffith A., Trinh, Mai-Han, Sundaram, Rajeshwari, Mendola, Pauline, Robinson, Sonia L., Bell, Erin M., Adeyeye, Temilayo, Lin, Tzu-Chun, and Yeung, Edwina H.
- Abstract
Maternal obesity may affect offspring asthma and atopic disease risk by altering fetal immune system development. However, few studies examine gestational weight gain (GWG).
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- 2022
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25. Perfluorochemicals and Endometriosis
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Louis, Germaine M. Buck, Peterson, C. Matthew, Chen, Zhen, Hediger, Mary L., Croughan, Mary S., Sundaram, Rajeshwari, Stanford, Joseph B., Fujimoto, Victor Y., Varner, Michael W., Giudice, Linda C., Kennedy, Anne, Sun, Liping, Wu, Qian, and Kannan, Kurunthachalam
- Abstract
Environmental chemicals may be associated with endometriosis. No published research has focused on the possible role of perfluorochemicals (PFCs) despite their widespread presence in human tissues.
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- 2012
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26. Validity of Self-Reported Time to Pregnancy
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Cooney, Maureen A., Louis, Germaine M. Buck, Sundaram, Rajeshwari, McGuiness, Bridget M., and Lynch, Courtney D.
- Abstract
The reliability of retrospective time to pregnancy (TTP) has been established, but its validity has been assessed in only 1 study, which had a short follow-up.
- Published
- 2009
- Full Text
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27. Changes in Cell-Cycle Kinetics Responsible for Limiting Somatic Growth in Mice
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Chang, Maria, Parker, Elizabeth A, Muller, Tessa J M, Haenen, Caroline, Mistry, Maanasi, Finkielstain, Gabriela P, Murphy-Ryan, Maureen, Barnes, Kevin M, Sundaram, Rajeshwari, and Baron, Jeffrey
- Abstract
In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with age, approaching zero as the animal approaches adult body size. To investigate the underlying changes in cell-cycle kinetics, [methyl-3H]thymidine and 5'-bromo-2'deoxyuridine were used to double-label proliferating cells in 1-, 2-, and 3-wk-old mice for four weeks. Proliferation of renal tubular epithelial cells and hepatocytes decreased with age. The average cell-cycle time did not increase in liver and increased only 1.7 fold in kidney. The fraction of cells in S-phase that will divide again declined approximately 10 fold with age. Concurrently, average cell area increased approximately 2 fold. The findings suggest that somatic growth deceleration primarily results not from an increase in cell-cycle time but from a decrease in growth fraction (fraction of cells that continue to proliferate). During the deceleration phase, cells appear to reach a proliferative limit and undergo their final cell divisions, staggered over time. Concomitantly, cells enlarge to a greater volume, perhaps because they are relieved of the size constraint imposed by cell division. In conclusion, a decline in growth fraction with age causes somatic growth deceleration and thus sets a fundamental limit on adult body size.
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- 2008
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28. Changes in Cell-Cycle Kinetics Responsible for Limiting Somatic Growth in Mice
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CHANG, MARIA, PARKER, ELIZABETH A., MULLER, TESSA J. M., HAENEN, CAROLINE, MISTRY, MAANASI, FINKIELSTAIN, GABRIELA P., MURPHY-RYAN, MAUREEN, BARNES, KEVIN M., SUNDARAM, RAJESHWARI, and BARON, JEFFREY
- Abstract
In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with age, approaching zero as the animal approaches adult body size. To investigate the underlying changes in cell-cycle kinetics, methyl-3Hthymidine and 5′-bromo-2′deoxyuridine were used to double-label proliferating cells in 1-, 2-, and 3-wk-old mice for four weeks. Proliferation of renal tubular epithelial cells and hepatocytes decreased with age. The average cell-cycle time did not increase in liver and increased only 1.7 fold in kidney. The fraction of cells in S-phase that will divide again declined approximately 10 fold with age. Concurrently, average cell area increased approximately 2 fold. The findings suggest that somatic growth deceleration primarily results not from an increase in cell-cycle time but from a decrease in growth fraction (fraction of cells that continue to proliferate). During the deceleration phase, cells appear to reach a proliferative limit and undergo their final cell divisions, staggered over time. Concomitantly, cells enlarge to a greater volume, perhaps because they are relieved of the size constraint imposed by cell division. In conclusion, a decline in growth fraction with age causes somatic growth deceleration and thus sets a fundamental limit on adult body size.
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- 2008
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29. 0236 Associations of Media Use and Nocturnal Sleep Duration Among US Adolescents: Mediating Effects of Chronotype.
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Haynie, Denise L, Maultsyby, Katherine, Lewin, Daniel, Lipsky, Leah, Sundaram, Rajeshwari, and Simons-Morton, Bruce
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- 2019
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30. Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies–Singletons
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Gleason, Jessica L., Tekola-Ayele, Fasil, Sundaram, Rajeshwari, Hinkle, Stefanie N., Vafai, Yassaman, Buck Louis, Germaine M., Gerlanc, Nicole, Amyx, Melissa, Bever, Alaina M., Smarr, Melissa M., Robinson, Morgan, Kannan, Kurunthachalam, and Grantz, Katherine L.
- Abstract
IMPORTANCE: Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. OBJECTIVE: To evaluate the association between maternal caffeine intake and neonatal anthropometry, testing effect modification by fast or slow caffeine metabolism genotype. DESIGN, SETTING, AND PARTICIPANTS: A longitudinal cohort study, the National Institute of Child Health and Human Development Fetal Growth Studies–Singletons, enrolled 2055 nonsmoking women at low risk for fetal growth abnormalities with complete information on caffeine consumption from 12 US clinical sites between 2009 and 2013. Secondary analysis was completed in 2020. EXPOSURES: Caffeine was evaluated by both plasma concentrations of caffeine and paraxanthine and self-reported caffeinated beverage consumption measured/reported at 10-13 weeks gestation. Caffeine metabolism defined as fast or slow using genotype information from the single nucleotide variant rs762551 (CYP1A2*1F). MAIN OUTCOMES AND MEASURES: Neonatal anthropometric measures, including birth weight, length, and head, abdominal, arm, and thigh circumferences, skin fold and fat mass measures. The ß coefficients represent the change in neonatal anthropometric measure per SD change in exposure. RESULTS: A total of 2055 participants had a mean (SD) age of 28.3 (5.5) years, mean (SD) body mass index of 23.6 (3.0), and 580 (28.2%) were Hispanic, 562 (27.4%) were White, 518 (25.2%) were Black, and 395 (19.2%) were Asian/Pacific Islander. Delivery occurred at a mean (SD) of 39.2 (1.7) gestational weeks. Compared with the first quartile of plasma caffeine level (=28 ng/mL), neonates of women in the fourth quartile (>659 ng/mL) had lower birth weight (ß?=?-84.3 g; 95% CI, -145.9 to -22.6 g; P?=?.04 for trend), length (ß?=?-0.44 cm; 95% CI, -0.78 to -0.12 cm; P?=?.04 for trend), and head (ß?=?-0.28 cm; 95% CI, -0.47 to -0.09 cm; P?<?.001 for trend), arm (ß?=?-0.25 cm; 95% CI, -0.41 to -0.09 cm: P?=?.02 for trend), and thigh (ß?=?-0.29 cm; 95% CI, -0.58 to -0.04 cm; P?=?.07 for trend) circumference. Similar reductions were observed for paraxanthine quartiles, and for continuous measures of caffeine and paraxanthine concentrations. Compared with women who reported drinking no caffeinated beverages, women who consumed approximately 50 mg per day (~?1/2 cup of coffee) had neonates with lower birth weight (ß?=?-66 g; 95% CI, -121 to -10 g), smaller arm (ß?=?-0.17 cm; 95% CI, -0.31 to -0.02 cm) and thigh (ß?=?-0.32 cm; 95% CI, -0.55 to -0.09 cm) circumference, and smaller anterior flank skin fold (ß?=?-0.24 mm; 95% CI, -0.47 to -0.01 mm). Results did not differ by fast or slow caffeine metabolism genotype. CONCLUSIONS AND RELEVANCE: In this cohort study, small reductions in neonatal anthropometric measurements with increasing caffeine consumption were observed. Findings suggest that caffeine consumption during pregnancy, even at levels much lower than the recommended 200 mg per day of caffeine, are associated with decreased fetal growth.
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- 2021
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31. Parental Weight Status and Offspring Behavioral Problems and Psychiatric Symptoms.
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Robinson, Sonia L., Ghassabian, Akhgar, Sundaram, Rajeshwari, Trinh, Mai-Han, Lin, Tzu-Chun, Bell, Erin M., and Yeung, Edwina
- Abstract
Objectives: To assess relations of prepregnancy maternal and paternal obesity with offspring behavioral problems and psychiatric symptoms at 7-8 years in the Upstate KIDS study, a prospective cohort study.Study Design: Maternal body mass index (BMI) was calculated from prepregnancy height and weight provided in vital records or self-report at 4 months postpartum. Mothers reported paternal height and weight. At 7-8 years, mothers indicated if their children had been diagnosed with ADHD or anxiety (n = 1915). Additionally, children's behavior was measured with the Strengths and Difficulties Questionnaire at 7 years of age (n = 1386) and the Vanderbilt ADHD Diagnostic Parent Rating Scale at 8 years of age (n = 1484). Based on Strengths and Difficulties Questionnaire scores, we identified children with borderline behavioral problems. Adjusted risk ratios (aRR) and 95% CIs were estimated with robust multivariable Poisson regression.Results: Compared with children of mothers with a BMI of <25, children whose mothers had BMI 25-30, 30-35, and ≥35 kg/m2 had higher risks of reported ADHD (aRR, 1.14, 95% CI, 0.78-1.69; aRR, 1.96, 95% CI, 1.29-2.98; and aRR, 1.82, 95% CI,1.21-2.74, respectively). Risks of hyperactivity problems identified by the Strengths and Difficulties Questionnaire and a positive screen for inattentive or hyperactive/impulsive behavior with the Vanderbilt ADHD Diagnostic Parent Rating Scale were also higher with increasing maternal prepregnancy BMI. Paternal BMI was not associated with child outcomes.Conclusions: Our findings suggest that maternal, rather than paternal, obesity is associated with maternal report of child ADHD diagnosis and inattentive or hyperactivity problems. Further research is needed to understand how maternal obesity might influence these behavioral changes during or after pregnancy. [ABSTRACT FROM AUTHOR]- Published
- 2020
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32. Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event
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Sundaram, Rajeshwari, Ma, Ling, and Ghoshal, Subhashis
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Recurrent events are often encountered in medical follow up studies. In addition, such recurrences have other quantities associated with them that are of considerable interest, for instance medical costs of the repeated hospitalizations and tumor size in cancer recurrences. These processes can be viewed as point processes, i.e. processes with arbitrary positive jump at each recurrence. An analysis of the mean function for such point processes have been proposed in the literature. However, such point processes are often skewed, leading to median as a more appropriate measure than the mean. Furthermore, the analysis of recurrent event data is often complicated by the presence of death. We propose a semiparametric model for assessing the effect of covariates on the quantiles of the point processes. We investigate both the finite sample as well as the large sample properties of the proposed estimators. We conclude with a real data analysis of the medical cost associated with the treatment of ovarian cancer.
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- 2017
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33. The Natural History of the Normal First Stage of Labor
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Zhang, Jun, Troendle, James, Mikolajczyk, Rafael, Sundaram, Rajeshwari, Beaver, Julie, and Fraser, William
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The inability to reduce the climbing rate of cesarean delivery worldwide is due, in part, to an inadequate understanding of the normal labor process, especially the first stage of labor. Improved diagnostic and interventional procedures are needed to manage women who labor slowly. This multicenter, prospective, observational study investigated patterns of labor in a large population, and assessed an alternative diagnostic approach for abnormal labor progression. The first stage of labor was studied using data from the National Collaborative Perinatal Project collected from 1959 to 1966. A total of 26,836 singleton term pregnancies delivered at 20 weeks or later were included in the final analysis. Other inclusion criteria were spontaneous onset of labor, a vertex fetal presentation at admission, and a normal perinatal outcome. To assess labor progression among nulliparous and multiparous pregnancies, a repeated-measures analysis with an eighth-degree polynomial model was used to construct average labor curves. An interval-censored regression assessed the duration of labor stratified by cervical dilation at admission, and the time for progression centimeter by centimeter.
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- 2010
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34. 275: Pre-gravid serum concentrations of perfluorooctanoic acid and the risk of gestational diabetes: a prospective study in the LIFE study.
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Zhang, Cuilin, Sundaram, Rajeshwari, Maisog, Jose, Barr, Dana, and Louis, Germaine Buck
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- 2014
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35. 334: Neonatal and maternal outcomes with prolonged second stage of labor.
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Laughon, S. Katherine, Berghella, Vincenzo, Sundaram, Rajeshwari, Reddy, Uma, Lu, Zhaohui, and Hoffman, Matt
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- 2013
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36. O-054.
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Louis, Germaine, Sundaram, Rajeshwari, Schisterman, Enrique, Sweeney, Anne, Lynch, Courtney, Gore-Langton, Rob, Maisog, Jose, Kim, Sungduk, Chen, Zhen, and Barr, Dana
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- 2012
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37. Induction of labor in a contemporary obstetric cohort.
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Laughon, S. Katherine, Zhang, Jun, Grewal, Jagteshwar, Sundaram, Rajeshwari, Beaver, Julie, and Reddy, Uma M.
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INDUCED labor (Obstetrics) ,OBSTETRICS ,COHORT analysis ,ELECTRONIC health records ,NULLIPARAS ,CERVIX uteri ,CESAREAN section - Abstract
Objective: We sought to describe details of labor induction, including precursors and methods, and associated vaginal delivery rates. Study Design: This was a retrospective cohort study of 208,695 electronic medical records from 19 hospitals across the United States, 2002 through 2008. Results: Induction occurred in 42.9% of nulliparas and 31.8% of multiparas and elective or no recorded indication for induction at term occurred in 35.5% and 44.1%, respectively. Elective induction at term in multiparas was highly successful (vaginal delivery 97%) compared to nulliparas (76.2%). For all precursors, cesarean delivery was more common in nulliparas in the latent compared to active phase of labor. Regardless of method, vaginal delivery rates were higher with a ripe vs unripe cervix, particularly for multiparas (86.6-100%). Conclusion: Induction of labor was a common obstetric intervention. Selecting appropriate candidates and waiting longer for labor to progress into the active phase would make an impact on decreasing the national cesarean delivery rate. [ABSTRACT FROM AUTHOR]
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- 2012
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38. Women's lifestyle behaviors while trying to become pregnant: evidence supporting preconception guidance.
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Lum, Kirsten J., Sundaram, Rajeshwari, and Buck Louis, Germaine M.
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LIFESTYLES ,SUBSTANCE abuse in pregnancy ,PRECONCEPTION care ,CONTRACEPTION ,MENSTRUAL cycle ,HABIT breaking ,SMOKING cessation ,TREATMENT of addictions - Abstract
Objective: We sought to prospectively measure women''s daily cigarette, alcohol, and caffeine use, while attempting pregnancy in relation to intentions to change. Study Design: This was a cohort comprising 90 women enrolled upon discontinuing contraception and followed up prospectively until pregnant. Women reported number of daily cigarettes, and alcoholic and caffeinated beverages for 459 menstrual cycles while attempting pregnancy. Results: A significant mean reduction in daily caffeinated drinks (estimate [EST] = −0.52; 95% confidence interval [CI], −0.70 to −0.33) was observed when compared to baseline usage. Intention to change was associated with a reduction in caffeinated drinks (EST = −0.32; 95% CI, −0.64 to 0.00), and with alcohol and cigarette usage from the first menstrual cycle (EST = −0.15; 95% CI, −0.28 to −0.02 and EST = −1.65; 95% CI, −3.12 to −0.19, respectively). Conclusion: A reduction in daily caffeine intake while attempting pregnancy was observed, but not in alcohol or cigarette use, underscoring the need for preconception guidance. [Copyright &y& Elsevier]
- Published
- 2011
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39. Validity of Self-reported Time to Pregnancy.
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Cooney, Maureen A., Buck Louis, Germaine M., Sundaram, Rajeshwari, McGuiness, Bridget M., and Lynch, Courtney D.
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- 2010
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40. 575: Predicting macrosomia by individualized fetal growth velocity and maternal characteristics.
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Zhang, Jun, Kim, Sung Duk, Albert, Paul, Sundaram, Rajeshwari, Klebanoff, Mark, and Grewal, Jagteshwar
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- 2009
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41. 114: Fetal growth and timing of parturition in humans: A prospective study.
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Zhang, Jun, Sundaram, Rajeshwari, Sun, Wenyu, and Troendle, James
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- 2007
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42. O-054
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Louis, Germaine, Sundaram, Rajeshwari, Schisterman, Enrique, Sweeney, Anne, Lynch, Courtney, Gore-Langton, Rob, Maisog, Jose, Kim, Sungduk, Chen, Zhen, and Barr, Dana
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- 2012
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43. Validity of Self-reported Time to Pregnancy
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Cooney, Maureen A., Louis, Germaine M. Buck, Sundaram, Rajeshwari, McGuiness, Bridget M., and Lynch, Courtney D.
- Published
- 2010
- Full Text
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