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Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event

Authors :
Sundaram, Rajeshwari
Ma, Ling
Ghoshal, Subhashis
Source :
International Journal of Biostatistics; February 2017, Vol. 13 Issue: 1
Publication Year :
2017

Abstract

Recurrent events are often encountered in medical follow up studies. In addition, such recurrences have other quantities associated with them that are of considerable interest, for instance medical costs of the repeated hospitalizations and tumor size in cancer recurrences. These processes can be viewed as point processes, i.e. processes with arbitrary positive jump at each recurrence. An analysis of the mean function for such point processes have been proposed in the literature. However, such point processes are often skewed, leading to median as a more appropriate measure than the mean. Furthermore, the analysis of recurrent event data is often complicated by the presence of death. We propose a semiparametric model for assessing the effect of covariates on the quantiles of the point processes. We investigate both the finite sample as well as the large sample properties of the proposed estimators. We conclude with a real data analysis of the medical cost associated with the treatment of ovarian cancer.

Details

Language :
English
ISSN :
2194573X and 15574679
Volume :
13
Issue :
1
Database :
Supplemental Index
Journal :
International Journal of Biostatistics
Publication Type :
Periodical
Accession number :
ejs42192129
Full Text :
https://doi.org/10.1515/ijb-2016-0057