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1. Impact of perioperative chemotherapy on survival outcomes among patients with metastatic colorectal cancer to the liver

Author: Baidoun, Firas, Merjaneh, Zahi, Nanah, Rama, Saad, Anas M, and Abdel-Rahman, Omar
Abstract: Aim:Compare overall survival (OS) between adjuvant and neoadjuvant chemotherapy and analyze the effect of chemotherapy on OS. Materials & methods:National Cancer Database was queried for patients diagnosed with metastatic colorectal adenocarcinoma with isolated liver metastases between 2004 and 2016. We evaluated the OS and chemotherapy effect using Kaplan-Meier estimates and multivariable cox regression analyses. Results:Total 6883 patients with metastatic colorectal cancer and liver metastases were included, of which 6042 patients were treated with surgery and chemotherapy and 841 patients were treated with surgery only. Patients who received neoadjuvant chemotherapy had better OS compared with patients who received adjuvant chemotherapy. Conclusion:Patients with colorectal cancer with isolated liver metastases who were treated with neoadjuvant chemotherapy had better OS compared with adjuvant chemotherapy.
Published: 2022
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2. The Association of Chronic Kidney Disease With Outcomes Following Percutaneous Left Atrial Appendage Closure.

Author: Ahuja, Keerat Rai, Ariss, Robert W., Nazir, Salik, Vyas, Rohit, Saad, Anas M., Macciocca, Michael, and Moukarbel, George V.
Abstract: The aim of this study was to investigate the associations of chronic kidney disease (CKD) and end-stage renal disease (ESRD) with in-hospital and short-term outcomes using a large national database representative of contemporary clinical practice. CKD and ESRD are associated with increased risk for stroke and bleeding in patients with atrial fibrillation on oral anticoagulation. Left atrial appendage closure (LAAC) may provide a reasonable alternative for these patients; however, the impact of CKD and ESRD on in-hospital and short-term outcomes following LAAC remain largely unknown. The Nationwide Readmissions Database was used to identify LAAC procedures from 2016 to 2017 in patients with no CKD, CKD (stages I-V), and ESRD. Multivariable logistic regression models were used to assess in-hospital and short-term outcomes. The primary outcome was in-hospital mortality. Of 21,274 patients who underwent LAAC during the study period, 3,954 (18.6%) had CKD and 571 (2.7%) had ESRD. ESRD was associated with increased risk for in-hospital mortality compared with no CKD (3.3% vs 0.4%; adjusted odds ratio: 6.48; 95% confidence interval: 3.35-12.50; P < 0.001) and CKD (3.3% vs 0.5%; adjusted odds ratio: 11.43; 95% confidence interval: 4.77-27.39; P < 0.001). CKD was associated with increased risk for in-hospital acute kidney injury or hemodialysis and stroke or transient ischemic attack. ESRD and CKD were associated with increased readmissions extending to 90 days compared with no CKD, and ESRD was associated with increased readmissions compared with CKD. There was no difference with respect to other in-hospital outcomes. ESRD is associated with higher in-hospital mortality, and CKD is associated with higher rates of stroke or transient ischemic attack in patients undergoing LAAC. Further research is needed to assess the impact of CKD and ESRD on long-term outcomes in these patients. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2021
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3. Supplemental calcium and vitamin D and long-term mortality in aortic stenosis

Author: Kassis, Nicholas, Hariri, Essa H, Karrthik, Antonette K, Ahuja, Keerat R, Layoun, Habib, Saad, Anas M, Gad, Mohamed M, Kaur, Manpreet, Bazarbashi, Najdat, Griffin, Brian P, Popovic, Zoran B, Harb, Serge C, Desai, Milind Y, and Kapadia, Samir R
Abstract: ObjectiveCalcium metabolism has long been implicated in aortic stenosis (AS). Studies assessing the long-term safety of oral calcium and/or vitamin D in AS are scarce yet imperative given the rising use among an elderly population prone to deficiency. We sought to identify the associations between supplemental calcium and vitamin D with mortality and progression of AS.MethodsIn this retrospective longitudinal study, patients aged ≥60 years with mild-moderate native AS were selected from the Cleveland Clinic Echocardiography Database from 2008 to 2016 and followed until 2018. Groups were stratified into no supplementation, supplementation with vitamin D alone and supplementation with calcium±vitamin D. The primary outcomes were mortality (all-cause, cardiovascular (CV) and non-CV) and aortic valve replacement (AVR), and the secondary outcome was AS progression by aortic valve area and peak/mean gradients.ResultsOf 2657 patients (mean age 74 years, 42% women) followed over a median duration of 69 months, 1292 (49%) did not supplement, 332 (12%) took vitamin D alone and 1033 (39%) supplemented with calcium±vitamin D. Calcium±vitamin D supplementation was associated with a significantly higher risk of all-cause mortality (absolute rate (AR)=43.0/1000 person-years; HR=1.31, 95% CI (1.07 to 1.62); p=0.009), CV mortality (AR=13.7/1000 person-years; HR=2.0, 95% CI (1.31 to 3.07); p=0.001) and AVR (AR=88.2/1000 person-years; HR=1.48, 95% CI (1.24 to 1.78); p<0.001). Any supplementation was not associated with longitudinal change in AS parameters in a linear mixed-effects model.ConclusionsSupplemental calcium with or without vitamin D is associated with lower survival and greater AVR in elderly patients with mild-moderate AS.
Published: 2022
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4. Takotsubo syndrome: Does "Diabetes Paradox" exist?

Author: Ahuja, Keerat Rai, Nazir, Salik, Jain, Vardhmaan, Isogai, Toshiaki, Saad, Anas M., Verma, Beni R., Shekhar, Shashank, Kumar, Ravi, Eltahawy, Ehab A., and Madias, John E.
Abstract: • Previous studies have shown conflicting data on the prevalence and association of diabetes mellitus (DM) with outcomes of Takotsubo syndrome (TTS). • We found lower prevalence of DM in TTS (19.3% vs 23.1%) during the study period. • No difference was noted for in-hospital mortality and other outcomes in patients with TTS with and without DM • TTS patients with complicated DM compared to uncomplicated DM were noted to have statistically significant lower in-hospital mortality Previous small-scale studies have reported conflicting findings regarding the prevalence of diabetes mellitus (DM) and its association with outcomes in patients with takotsubo syndrome (TTS) We sought to assess the prevalence of DM and its association with outcomes in TTS patients. Nationwide inpatient sample (NIS) was queried to extract patient information from January 1, 2009 to September 30, 2015. Propensity score matching (PSM) was done to compare mortality and other in-hospital outcomes. A total of 40,327 hospitalizations for TTS were included. The prevalence of DM in TTS was 19.3% vs 23.1% (p -value < 0.01) in patients without TTS in the NIS from 2009 to 2015. In the PSM cohort, there was no difference in in-hospital mortality (1.1% vs 1.4%; p = 0.76), stroke (1.2% vs 0.9%; p = 0.09), cardiogenic shock (3.7% vs 3.9%; p = 0.61), cardiac arrest (1.2% vs 1.2%; p = 0.94), ventricular arrhythmias (3.7% vs 3.3%; p = 0.23), circulatory support (2.1% vs 1.8%; p = 0.17), and invasive mechanical ventilation (4.9% vs 4.7%; p = 0.54) in TTS patients with versus without diabetes. In sub-group analysis, diabetes with chronic complications patients were found to have lower mortality (0.7% vs 2.0%; p = 0.04) compared to patients without diabetes and those with uncomplicated diabetes (0.6% vs 2.6%; p = 0.002). Prevalence of DM was lower in TTS in comparison to patients without TTS. In addition, complicated DM patients were found to have lower in-hospital mortality. Further studies are needed to assess the mid and long-term outcomes of DM with and without chronic complications in TTS Title: Conceptual Pathophysiologic Autonomic Nervous System (ANS)-Heart, and ANS-Adrenals Connections in Non-Diabetic and Diabetic Patients with Takotsubo Syndrome Legend: Schematic to illustrate the proposed mechanism of catecholamine-induced cardiomyocyte injury operating via norepinephrine release at the neural-myocardial junction and/or circulating catecholamines, mainly epinephrine released by the adrenals, in patient with takotsubo syndrome and intact neural connections in nondiabetic patients (left) and neuropathy-mediated damages neural connections in in diabetic patients (right). [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2021
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5. Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990–2050

Author: Micah, Angela E, Cogswell, Ian E, Cunningham, Brandon, Ezoe, Satoshi, Harle, Anton C, Maddison, Emilie R, McCracken, Darrah, Nomura, Shuhei, Simpson, Kyle E, Stutzman, Hayley N, Tsakalos, Golsum, Wallace, Lindsey E, Zhao, Yingxi, Zende, Rahul R, Abbafati, Cristiana, Abdelmasseh, Michael, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abolhassani, Hassan, Abrigo, Michael R M, Adhikari, Tara Ballav, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Ajami, Marjan, Aji, Budi, Akalu, Yonas, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alemayehu, Yosef, Alhassan, Robert Kaba, Alinia, Cyrus, Aljunid, Syed Mohamed, Almustanyir, Sami Almustanyir, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amini, Saeed, Amini-Rarani, Mostafa, Amu, Hubert, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Angell, Blake, Anjomshoa, Mina, Antonio, Carl Abelardo T, Antony, Catherine M, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Aripov, Timur, Arrigo, Alessandro, Ashraf, Tahira, Atnafu, Desta Debalkie, Ausloos, Marcel, Avila-Burgos, Leticia, Awan, Asma Tahir, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azhar, Gulrez Shah, Babalola, Tesleem Kayode, Bahrami, Mohammad Amin, Baig, Atif Amin, Banach, Maciej, Barati, Nastaran, Bärnighausen, Till Winfried, Barrow, Amadou, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Benzian, Habib, Berman, Adam E, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bibi, Sadia, Bijani, Ali, Bodolica, Virginia, Bragazzi, Nicola Luigi, Braithwaite, Dejana, Breitborde, Nicholas J K, Breusov, Alexey V, Briko, Nikolay Ivanovich, Busse, Reinhard, Cahuana-Hurtado, Lucero, Callander, Emily Joy, Cámera, Luis Alberto, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chen, Simiao, Cicero, Arrigo Francesco Giuseppe, Dadras, Omid, Dahlawi, Saad M A, Dai, Xiaochen, Dalal, Koustuv, Dandona, Lalit, Dandona, Rakhi, Davitoiu, Dragos Virgil, De Neve, Jan-Walter, de Sá-Junior, Antonio Reis, Denova-Gutiérrez, Edgar, Dhamnetiya, Deepak, Dharmaratne, Samath Dhamminda, Doshmangir, Leila, Dube, John, Ehsani-Chimeh, Elham, El Sayed Zaki, Maysaa, El Tantawi, Maha, Eskandarieh, Sharareh, Farzadfar, Farshad, Ferede, Tomas Y, Fischer, Florian, Foigt, Nataliya A, Freitas, Alberto, Friedman, Sara D, Fukumoto, Takeshi, Fullman, Nancy, Gaal, Peter Andras, Gad, Mohamed M, Garcia-Gordillo, MA, Garg, Tushar, Ghafourifard, Mansour, Ghashghaee, Ahmad, Gholamian, Asadollah, Gholamrezanezhad, Ali, Ghozali, Ghozali, Gilani, Syed Amir, Glăvan, Ionela-Roxana, Glushkova, Ekaterina Vladimirovna, Goharinezhad, Salime, Golechha, Mahaveer, Goli, Srinivas, Guha, Avirup, Gupta, Veer Bala, Gupta, Vivek Kumar, Haakenstad, Annie, Haider, Mohammad Rifat, Hailu, Alemayehu, Hamidi, Samer, Hanif, Asif, Harapan, Harapan, Hartono, Risky Kusuma, Hasaballah, Ahmed I, Hassan, Shoaib, Hassanein, Mohamed H, Hayat, Khezar, Hegazy, Mohamed I, Heidari, Golnaz, Hendrie, Delia, Heredia-Pi, Ileana, Herteliu, Claudiu, Hezam, Kamal, Holla, Ramesh, Hossain, Sheikh Jamal, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Huda, Tanvir M, Hwang, Bing-Fang, Iavicoli, Ivo, Idrisov, Bulat, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayawardena, Ranil, Jazayeri, Seyed Behzad, Jha, Ravi Prakash, Jonas, Jost B, Joo, Tamas, Joukar, Farahnaz, Jürisson, Mikk, Kaambwa, Billingsley, Kalhor, Rohollah, Kanchan, Tanuj, Kandel, Himal, Karami Matin, Behzad, Karimi, Salah Eddin, Kassahun, Getinet, Kayode, Gbenga A, Kazemi Karyani, Ali, Keikavoosi-Arani, Leila, Khader, Yousef Saleh, Khajuria, Himanshu, Khalilov, Rovshan, Khammarnia, Mohammad, Khan, Junaid, Khubchandani, Jagdish, Kianipour, Neda, Kim, Gyu Ri, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kohler, Stefan, Kosen, Soewarta, Koteeswaran, Rajasekaran, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Kumar, G Anil, Kusuma, Dian, Lamnisos, Demetris, Lansingh, Van Charles, Larsson, Anders O, Lasrado, Savita, Le, Long Khanh Dao, Lee, Shaun Wen Huey, Lee, Yeong Yeh, Lim, Stephen S, Lobo, Stany W, Lozano, Rafael, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahdavi, Mokhtar Mahdavi, Majeed, Azeem, Makki, Alaa, Maleki, Afshin, Malekzadeh, Reza, Manda, Ana Laura, Mansour-Ghanaei, Fariborz, Mansournia, Mohammad Ali, Marrugo Arnedo, Carlos Alberto, Martinez-Valle, Adolfo, Masoumi, Seyedeh Zahra, Maude, Richard James, McKee, Martin, Medina-Solís, Carlo Eduardo, Menezes, Ritesh G, Meretoja, Atte, Meretoja, Tuomo J, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Milevska Kostova, Neda, Miller, Ted R, Mini, GK, Mirica, Andreea, Mirrakhimov, Erkin M, Mohajer, Bahram, Mohamed, Teroj Abdulrahman, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Moitra, Modhurima, Mokdad, Ali H, Molokhia, Mariam, Moni, Mohammad Ali, Moradi, Yousef, Morze, Jakub, Mousavi, Seyyed Meysam, Mpundu-Kaambwa, Christine, Muriithi, Moses K, Muthupandian, Saravanan, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Nangia, Vinay, Naqvi, Atta Abbas, Narayana, Aparna Ichalangod, Nascimento, Bruno Ramos, Naveed, Muhammad, Nayak, Biswa Prakash, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Neupane Kandel, Sandhya, Nguyen, Trang Huyen, Nonvignon, Justice, Noubiap, Jean Jacques, Nwatah, Vincent Ebuka, Oancea, Bogdan, Ojelabi, Foluke Adetola Ogunyemi, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Olgiati, Stefano, Olusanya, Jacob Olusegun, Onwujekwe, Obinna E, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Palladino, Raffaele, Panda-Jonas, Songhomitra, Park, Eun-Cheol, Pashazadeh Kan, Fatemeh, Pawar, Shrikant, Pazoki Toroudi, Hamidreza, Pereira, David M, Perianayagam, Arokiasamy, Pesudovs, Konrad, Piccinelli, Cristiano, Postma, Maarten J, Prada, Sergio I, Rabiee, Mohammad, Rabiee, Navid, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahmani, Amir Masoud, Ram, Usha, Ranabhat, Chhabi Lal, Ranasinghe, Priyanga, Rao, Chythra R, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Reiner Jr, Robert C, Renzaho, Andre M N, Reshmi, Bhageerathy, Riaz, Mavra A, Ripon, Rezaul Karim, Saad, Anas M, Sahraian, Mohammad Ali, Sahu, Maitreyi, Salama, Joseph S, Salehi, Sana, Samy, Abdallah M, Sanabria, Juan, Sanmarchi, Francesco, Santos, João Vasco, Santric-Milicevic, Milena M, Sathian, Brijesh, Savic, Miloje, Saxena, Deepak, Sayyah, Mehdi, Schwendicke, Falk, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Seylani, Allen, Shahabi, Saeed, Shaikh, Masood Ali, Sheikh, Aziz, Shetty, Adithi, Shetty, Pavanchand H, Shibuya, Kenji, Shrime, Mark G, Shuja, Kanwar Hamza, Singh, Jasvinder A, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani, Shahin, Soofi, Moslem, Spurlock, Emma Elizabeth, Stefan, Simona Cătălina, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Taddele, Biruk Wogayehu, Tefera, Yonas Getaye, Thavamani, Aravind, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tudor Car, Lorainne, Ullah, Anayat, Ullah, Saif, Umar, Nasir, Undurraga, Eduardo A, Valdez, Pascual R, Vasankari, Tommi Juhani, Villafañe, Jorge Hugo, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vollmer, Sebastian, Vos, Theo, Vu, Giang Thu, Vu, Linh Gia, Wamai, Richard G, Werdecker, Andrea, Woldekidan, Mesfin Agachew, Wubishet, Befikadu Legesse, Xu, Gelin, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yiğit, Vahit, Yip, Paul, Yirdaw, Birhanu Wubale, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Yunusa, Ismaeel, Zahirian Moghadam, Telma, Zandian, Hamed, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Ziapour, Arash, Zuniga, Yves Miel H, Hay, Simon I, Murray, Christopher J L, and Dieleman, Joseph L
Abstract: The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020.
Published: 2021
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6. Prognostic and predictive value of microsatellite instability status among patients with colorectal cancer

Author: Baidoun, Firas, Saad, Anas M, and Abdel-Rahman, Omar
Abstract: Objectives:Compare overall survival (OS) between microsatellite instability (MSI) high and MSI-stable and analyze the effect of chemotherapy on OS. Methods:National cancer database was queried for patients diagnosed with colorectal adenocarcinoma between 2010 and 2016. We evaluated the OS and the chemotherapy effect using Kaplan–Meier estimates and multivariate Cox regression analyses. Results:Total of 30,436 stage II patients and 30,302 stage III patients were included. In stage II with high-risk features and MSI-high, patients who received chemotherapy had better OS compared to patients who didn't receive chemotherapy. The same was found in stage II with no high-risk features and MSI-high group. Conclusion:Stage II colorectal cancer patients with high-risk features and MSI-high who received chemotherapy have better OS compared to patients who didn't receive chemotherapy.
Published: 2021
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7. Temporal Trends of Transcatheter Edge-to-Edge Repair of the Mitral Valve Short-Term Outcomes in the United States: Nationwide Representative Study

Author: Abdelfattah, Omar M., Saad, Anas M., Hisung, Ingrid, Abushouk, Abdelrahman I., Gad, Mohamed M., Okasha, Osama, Isogai, Toshiaki, Ahuja, Keerat R., Shekhar, Shashank, Burns, Daniel J. P., Krishnaswamy, Amar, and Kapadia, Samir R.
Abstract: ABSTRACTBackground: Transcatheter edge-to-edge repair of the mitral valve (TEER) has recently emerged as a viable treatment option in high-risk patients with severe mitral regurgitation. The present study investigated the trends in TEER short-term outcomes during 2014–2018.Methods: We performed a retrospective study using the Nationwide Readmissions Database. We analyzed data on the in-hospital and 30-day outcomes of patients who underwent TEER procedure during 2014–2018.Results: A total of 22,914 patients underwent TEER; 1,674 in 2014, 3,252 in 2015, 4,645 in 2016, 6,000 in 2017, and 7,343 in 2018 with a median age of 78, 80, 81, and 80 years, respectively, with a 4.2 fold increase in TEER utilization. Heart failure was present in 75.6%, and 83.6% of patients, in 2014, and 2018 respectively, while 73.3%, and 85.3% of patients, respectively, had hypertension. In-hospital mortality following TEER was significantly decreased from 3.9% in 2014 to 2% in 2018 (P< 0.001). Similarly, stroke rates were decreased from 1.2% in 2014 to 1% in 2018 (P= 0.093), and the median length of hospital stay was significantly shortened from 4 to 2 days (P< 0.001). The overall 30-day readmission rate was 15.3% and did not change significantly over the study period (P= 0.876); however, the 30-day HF readmission rate exhibited a significant decline from 4.7% in 2014 to 0.6% in 2018 (P< 0.001).Conclusion: Although TEER therapy is now offered to a more critically ill and larger patient population in the United States, the outcomes of patients undergoing TEER are improving with decreasing mortality, morbidity, and hospital stay.Abbreviations: TEER: Transcatheter edge-to-edge repair of the mitral valve (TEER); NRD: National Readmissions Database; MR: Mitral Regurgitation; DMR: Degenerative Mitral Regurgitation; FMR: Functional Mitral Regurgitation; HF: Heart failure; LVEF: Left Ventricular Ejection Fraction; GDMT: Guideline-Directed Management and Therapy; AKI: Acute Kidney Injury; MI: Myocardial infarction
Published: 2021
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8. Causes of Death After Neuroendocrine Tumors Diagnosis

Author: Sonbol, Mohamad Bassam, Saad, Anas M., Gonzalez-Velez, Miguel, Starr, Jason, and Halfdanarson, Thorvardur R.
Abstract: Supplemental digital content is available in the text.
Published: 2021
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9. Short-Term Outcomes of Transcatheter Aortic Valve Replacement in Kidney Transplant Recipients: A Nationwide Representative Study

Author: Hassanein, Mohamed, Abdelfattah, Omar M., Saad, Anas M., Isogai, Toshiaki, Gad, Mohamed M., Ahuja, Keerat R., Ahmed, Taha, Shekhar, Shashank, Fatica, Richard, Poggio, Emilio, and Kapadia, Samir R.
Abstract: ABSTRACTBackground: Kidney transplant is the preferred treatment for end-stage kidney disease due to a better quality of life and lower morbidity and mortality than dialysis. These patients are considered high-risk patients for surgical interventions. Transcatheter aortic valve replacement (TAVR) has been introduced as an alternative to surgical aortic valve replacement in patients at high operative risk with aortic stenosis (AS). However, the outcomes of TAVR in kidney transplant patients regarding benefits and harms have not been well-studied in nationally representative data.Methods: Patients hospitalized for TAVR between January 2012 and December 2017 were identified retrospectively in the Nationwide Readmissions Database (NRD). Patients were subdivided based on having a previous history of kidney transplant.Results: Our study included 171,011 TAVR patients, of which 0.4% had a history of functioning kidney transplant. Patients with a history of kidney transplant generally had more rates of comorbidities and were more likely to develop in-hospital hemorrhagic stroke (0.7% vs. 0.1%, P= 0.004), ischemic stroke (4.5% vs. 2%, P< 0.001), acute kidney injury (25.3% vs. 13.4%, P< 0.001), and sepsis (3.9% vs. 1.6%, P< 0.001), but showed similar in-hospital mortality rates. These findings were confirmed after adjusting for other comorbidities.Conclusion: Patients with a history of kidney transplantation experience an increased risk of adverse outcomes following TAVR compared to non-kidney transplant patients. Further attention should be directed to measures to improve such outcomes in kidney transplant patients undergoing TAVR.Abbreviations:KT: kidney transplant; KTRs: kidney transplant recipients; TAVR: transcatheter aortic valve replacement; AS: aortic stenosis; SAVR: surgical aortic valve replacement; IHS: in-hospital stroke; AKI: acute kidney injury; ESKD: end-stage kidney disease; CKD: chronic kidney disease; TCEP: transcatheter cerebral embolic protection; DSCT: dual source computed tomography; VLCV: very low contrast volume
Published: 2021
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10. Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): From Guidelines to Clinical Practice

Author: Abdelfattah, Omar M., Hassanein, Mohamed, Saad, Anas M., Abela, George, and Aldasouqi, Saleh
Abstract: Background: Lipid profiles have been used for the purposes of health screening and monitoring of the effects of lipid-lowering medications, especially in patients with diabetes who are prone to hyperlipidemia. Fasting for lipid profiles has been the norm for the past decades. This long-lasting tradition poses a risk of hypoglycemia, especially in patients with diabetes. Objective: Our aim is to review the overlooked occurrence of hypoglycemia in patients who fast for laboratory tests, especially lipid profile tests, and commute to the laboratory facility while fasting; a condition we titled “Fasting-Evoked En route Hypoglycemia in Diabetes patients” or “FEEHD”. We also review its prevalence and clinical impact on patients with diabetes. Methods: We undertook an extensive literature search using search engines such as PubMed and Google Scholar. We used the following keywords for the search: Fasting, Non-fasting; Hypoglycemia; Hypoglycemic Agents; Laboratory Tests; Glucose, Hypoglycemia, Lipid Profiles, FEEHD. Results: Our literature review has shown that the prevalence of FEEHD is alarmingly high (17-21% of patients at risk). This form of hypoglycemia is under recognized in the clinical practice despite its frequent occurrence. Recent changes in various international guidelines have uniformly endorsed the utilization of non-fasting lipid profiles as the new standard for obtaining lipid profiles with the exception of certain conditions. Multiple studies showed the efficacy of non-fasting lipid tests in comparison to fasting lipid tests, in routine clinical practice. Conclusion: We hope to increase awareness among clinicians about this overlooked and potentially harmful form of hypoglycemia in patients with diabetes, which can be easily avoided. We also hope to call upon clinicians to consider changing the habit of ordering lipid profiles in the fasting state, which has been recently shown to be largely unnecessary in routine clinical settings, with few exceptions in selected cases.
Published: 2020
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11. Epidemiology of Cholangiocarcinoma; United States Incidence and Mortality Trends

Author: Gad, Mohamed M., Saad, Anas M., Faisaluddin, Mohammed, Gaman, Mihnea Alexandru, Ruhban, Inas A., Jazieh, Khalid A., Al-Husseini, Muneer J., Simons-Linares, Carlos Roberto, Sonbol, M. Bassam, and Estfan, Bassam N.
Abstract: •Cholangiocarcinoma is an aggressive malignancy with few available studies assessing incidence and mortality.•Cholangiocarcinoma incidence rates have significantly increased over the study period (2000-2015).•Cholangiocarcinoma mortality increased significantly over the study period but decreased after 2013.•Incidence and mortality of cholangiocarcinoma were increasing in the study period with significant observed disparities based on race and gender.
Published: 2020
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12. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017

Author: Reiner, Robert C, Wiens, Kirsten E, Deshpande, Aniruddha, Baumann, Mathew M, Lindstedt, Paulina A, Blacker, Brigette F, Troeger, Christopher E, Earl, Lucas, Munro, Sandra B, Abate, Degu, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Getaneh, Abegaz, Kedir Hussein, Abreu, Lucas Guimarães, Abrigo, Michael R M, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adabi, Maryam, Adebayo, Oladimeji M, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Afarideh, Mohsen, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmed, Anwar E, Ahmed, Muktar Beshir, Ahmed, Rushdia, Ajumobi, Olufemi, Akal, Chalachew Genet, Akalu, Temesgen Yihunie, Akanda, Ali S, Alamene, Genet Melak, Alanzi, Turki M, Albright, James R, Alcalde Rabanal, Jacqueline Elizabeth, Alemnew, Birhan Tamene, Alemu, Zewdie Aderaw, Ali, Beriwan Abdulqadir, Ali, Muhammad, Alijanzadeh, Mehran, Alipour, Vahid, Aljunid, Syed Mohamed, Almasi, Ali, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M, Altirkawi, Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amare, Azmeraw T, Amini, Saeed, Amit, Arianna Maever Loreche, Andrei, Catalina Liliana, Anegago, Masresha Tessema, Anjomshoa, Mina, Ansari, Fereshteh, Antonio, Carl Abelardo T, Antriyandarti, Ernoiz, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Aremu, Olatunde, Armoon, Bahram, Aryal, Krishna K, Arzani, Afsaneh, Asadi-Lari, Mohsen, Ashagre, Alebachew Fasil, Atalay, Hagos Tasew, Atique, Suleman, Atre, Sachin R, Ausloos, Marcel, Avila-Burgos, Leticia, Awasthi, Ashish, Awoke, Nefsu, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Ayele, Asnakew Achaw, Aynalem, Yared A Asmare, Azari, Samad, Babaee, Ebrahim, Badawi, Alaa, Bakkannavar, Shankar M, Balakrishnan, Senthilkumar, Bali, Ayele Geleto, Banach, Maciej, Barac, Aleksandra, Bärnighausen, Till Winfried, Basaleem, Huda, Bassat, Quique, Bayati, Mohsen, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Yibeltal Alemu, Bell, Michelle L, Bennett, Derrick A, Berbada, Dessalegn Ajema, Beyranvand, Tina, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bijani, Ali, Bikbov, Boris, Biswas, Raaj Kishore, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Brady, Oliver J, Bragazzi, Nicola Luigi, Briko, Nikolay Ivanovich, Briko, Andrey Nikolaevich, Burugina Nagaraja, Sharath, Butt, Zahid A, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cárdenas, Rosario, Carvalho, Félix, Castro, Franz, Chansa, Collins, Chatterjee, Pranab, Chattu, Vijay Kumar, Chauhan, Bal Govind, Chin, Ken Lee, Christopher, Devasahayam J, Chu, Dinh-Toi, Claro, Rafael M, Cormier, Natalie M, Costa, Vera M, Damiani, Giovanni, Daoud, Farah, Dandona, Lalit, Dandona, Rakhi, Darwish, Amira Hamed, Daryani, Ahmad, Das, Jai K, Das Gupta, Rajat, Dasa, Tamirat Tesfaye, Davila, Claudio Alberto, Davis Weaver, Nicole, Davitoiu, Dragos Virgil, De Neve, Jan-Walter, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demoz, Gebre Teklemariam, Denova-Gutiérrez, Edgar, Deribe, Kebede, Desalew, Assefa, Dessie, Getenet Ayalew, Dharmaratne, Samath Dhamminda, Dhillon, Preeti, Dhimal, Meghnath, Dhungana, Govinda Prasad, Diaz, Daniel, Ding, Eric L, Diro, Helen Derara, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Dolecek, Christiane, Dubey, Manisha, Dubljanin, Eleonora, Duko Adema, Bereket, Dunachie, Susanna J, Durães, Andre R, Duraisamy, Senbagam, Effiong, Andem, Eftekhari, Aziz, El Sayed, Iman, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elemineh, Demelash Abewa, El-Jaafary, Shaimaa I, Elkout, Hajer, Elsharkawy, Aisha, Enany, Shymaa, Endalamfaw, Aklilu, Endalew, Daniel Adane, Eskandarieh, Sharareh, Esteghamati, Alireza, Etemadi, Arash, Farag, Tamer H, Faraon, Emerito Jose A, Fareed, Mohammad, Faridnia, Roghiyeh, Farioli, Andrea, Faro, Andre, Farzam, Hossein, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Fentahun, Netsanet, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Francis, Joel Msafiri, Franklin, Richard Charles, Frostad, Joseph Jon, Fukumoto, Takeshi, Gayesa, Reta Tsegaye, Gebremariam, Kidane Tadesse, Gebremedhin, Ketema Bizuwork Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gedefaw, Getnet Azeze, Geramo, Yilma Chisha Dea, Geta, Birhanu, Gezae, Kebede Embaye, Ghashghaee, Ahmad, Ghassemi, Fariba, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Goli, Srinivas, Gomes, Nelson G M, Gopalani, Sameer Vali, Goulart, Bárbara Niegia Garcia, Grada, Ayman, Gugnani, Harish Chander, Guido, Davide, Guimares, Rafael Alves, Guo, Yuming, Gupta, Rajeev, Gupta, Rahul, Hafezi-Nejad, Nima, Haile, Michael Tamene, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian James, Handiso, Demelash Woldeyohannes, Haririan, Hamidreza, Hariyani, Ninuk, Hasaballah, Ahmed I, Hasan, Md. Mehedi, Hasanzadeh, Amir, Hassankhani, Hadi, Hassen, Hamid Yimam, Hayelom, Desta Haftu, Heidari, Behnam, Henry, Nathaniel J, Herteliu, Claudiu, Heydarpour, Fatemeh, Hidru, Hagos D de, Hoang, Chi Linh, Hoogar, Praveen, Hoseini-Ghahfarokhi, Mojtaba, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Househ, Mowafa, Hu, Guoqing, Humayun, Ayesha, Hussain, Syed Ather, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Milena D, Inbaraj, Leeberk Raja, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwu, Chinwe Juliana, Jaca, Anelisa, Jafari Balalami, Nader, Jahanmehr, Nader, Jakovljevic, Mihajlo, Jalali, Amir, Jayatilleke, Achala Upendra, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jia, Peng, Johnson, Kimberly B, Jonas, Jost B, Jozwiak, Jacek Jerzy, Kabir, Ali, Kabir, Zubair, Kahsay, Amaha, Kalani, Hamed, Kanchan, Tanuj, Karami Matin, Behzad, Karch, André, Karki, Surendra, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kayode, Gbenga A, Kazemi Karyani, Ali, Keiyoro, Peter Njenga, Ketema, Daniel Bekele, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalid, Nauman, Khalil, Ali Talha, Khalil, Ibrahim, Khalilov, Rovshan, Khan, Md Nuruzzaman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Junaid, Khatab, Khaled, Khater, Amir, Khater, Mona M, Khatony, Alireza, Khayamzadeh, Maryam, Khazaei, Mohammad, Khazaei, Salman, Khodamoradi, Ehsan, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Aliasghar A, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Sezer, Kisa, Adnan, Kissoon, Niranjan, Kondlahalli, Shivakumar KM KM M, Kosek, Margaret N, Koyanagi, Ai, Kraemer, Moritz U G, Krishan, Kewal, Kugbey, Nuworza, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Aparna, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lansingh, Van C, Lasrado, Savita, Lee, Paul H, Leili, Mostafa, Lenjebo, Tsegaye Tsegaye Lolaso Lolaso, Levine, Aubrey J, Lewycka, Sonia, Li, Shanshan, Linn, Shai, Lodha, Rakesh, Longbottom, Joshua, Lopukhov, Platon D, Magdeldin, Sameh, Mahasha, Phetole Walter, Mahotra, Narayan Bahadur, Malta, Deborah Carvalho, Mamun, Abdullah A, Manafi, Navid, Manafi, Farzad, Manda, Ana-Laura, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Marczak, Laurie B, Martins-Melo, Francisco Rogerlândio, März, Winfried, Masaka, Anthony, Mathur, Manu Raj, Maulik, Pallab K, Mayala, Benjamin K, McAlinden, Colm, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M, Meles, Gebrekiros Gebremichael, Melese, Addisu, Memish, Ziad A, Mena, Alemayehu Toma, Menezes, Ritesh G, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Mengistu, Getnet, Meretoja, Tuomo J, Miazgowski, Bartosz, Mihretie, Kebadnew Mulatu M, Miller-Petrie, Molly K, Mills, Edward J, Mir, Seyed Mostafa, Mirabi, Parvaneh, Mirrakhimov, Erkin M, Mohamadi-Bolbanabad, Amjad, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammad, Dara K, Mohammad Darwesh, Aso, Mohammad Gholi Mezerji, Naser, Mohammadifard, Noushin, Mohammed, Ammas Siraj, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moodley, Yoshan, Moradi, Masoud, Moradi, Ghobad, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moraga, Paula, Mosapour, Abbas, Mouodi, Simin, Mousavi, Seyyed Meysam, Mozaffor, Miliva Mozaffor Mozaffor, Muluneh, Atalay Goshu, Muriithi, Moses K, Murray, Christopher J L, Murthy, GVS, Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Najafi, Farid, Nangia, Vinay, Nazari, Javad, Ndwandwe, Duduzile Edith, Negoi, Ionut, Ngunjiri, Josephine W, Nguyen, QuynhAnh P, Nguyen, Trang Huyen, Nguyen, Cuong Tat, Nigatu, Dabere, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A, Nojomi, Marzieh, Noubiap, Jean Jacques, Oh, In-Hwan, Okpala, Oluchi, Olagunju, Andrew T, Omar Bali, Ahmed, Onwujekwe, Obinna E, Ortega-Altamirano, Doris D V, Osarenotor, Osayomwanbo, Osei, Frank B, Owolabi, Mayowa Ojo, P A, Mahesh, Padubidri, Jagadish Rao, Pana, Adrian, Pashaei, Tahereh, Pati, Sanghamitra, Patle, Ajay, Patton, George C, Paulos, Kebreab, Pepito, Veincent Christian Filipino, Pereira, Alexandre, Perico, Norberto, Pesudovs, Konrad, Pigott, David M, Piroozi, Bakhtiar, Platts-Mills, James A, Poljak, Mario, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Poustchi, Hossein, Prada, Sergio I, Preotescu, Liliana, Quintana, Hedley, Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rajati, Fatemeh, Ramezanzadeh, Kiana, Rana, Saleem M, Ranabhat, Chhabi Lal, Rasella, Davide, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Reta, Melese Abate, Rezaei, Satar, Ribeiro, Ana Isabel, Rickard, Jennifer, Rios González, Carlos Miguel, Rios-Blancas, Maria Jesus, Roever, Leonardo, Ronfani, Luca, Roro, Elias Merdassa, Rostami, Ali, Rothenbacher, Dietrich, Rubagotti, Enrico, Rubino, Salvatore, Saad, Anas M, Sabour, Siamak, Sadeghi, Ehsan, Safari, Saeed, Safdarian, Mahdi, Sagar, Rajesh, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Salehi, Farkhonde, Salehi Zahabi, Saleh, Salem, Marwa R Rashad, Salem, Hosni, Salimi, Yahya, Salimzadeh, Hamideh, Sambala, Evanson Zondani, Samy, Abdallah M, Sanabria, Juan, Santos, Itamar S, Saraswathy, Sivan Yegnanarayana Iyer, Sarker, Abdur Razzaque, Sartorius, Benn, Sathian, Brijesh, Satpathy, Maheswar, Sbarra, Alyssa N, Schaeffer, Lauren E, Schwebel, David C, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Shabaninejad, Hosein, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shallo, Seifadin Ahmed, Shams-Beyranvand, Mehran, Shamsi, MohammadBagher, Shamsizadeh, Morteza, Sharif, Mehdi, Shey, Muki Shehu, Shibuya, Kenji, Shiferaw, Wondimeneh Shibabaw Shibabaw, Shigematsu, Mika, Shil, Apurba, Shin, Jae Il, Shiri, Rahman, Shirkoohi, Reza, Si, Si, Siabani, Soraya, Singh, Jasvinder A, Singh, Narinder Pal, Sinha, Dhirendra Narain, Sisay, Malede Mequanent, Skiadaresi, Eirini, Smith, David L, Sobhiyeh, Mohammad Reza, Sokhan, Anton, Soofi, Moslem, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Sreeramareddy, Chandrashekhar T, Sudaryanto, Agus, Sufiyan, Mu'awiyyah Babale, Suleria, Hafiz Ansar Rasul, Sykes, Bryan L, Tamirat, Koku Sisay, Tassew, Aberash Abay, Taveira, Nuno, Taye, Bineyam, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tesfay, Berhe etsay, Tesfay, Fisaha Haile, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thirunavukkarasu, Sathish, Thomas, Nihal, Tlaye, Kenean Getaneh, Tlou, Boikhutso, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Khanh Bao, Trihandini, Indang, Ullah, Irfan, Unnikrishnan, Bhaskaran, Valadan Tahbaz, Sahel, Valdez, Pascual R, Varughese, Santosh, Veisani, Yousef, Violante, Francesco S, Vollmer, Sebastian, Vos, Theo, Wada, Fiseha Wadilo, Waheed, Yasir, Wang, Yafeng, Wang, Yuan-Pang, Weldesamuel, Girmay Teklay, Welgan, Catherine A, Westerman, Ronny, Wiangkham, Taweewat, Wijeratne, Tissa, Wiysonge, Charles Shey Shey, Wolde, Haileab Fekadu, Wondafrash, Dawit Zewdu, Wonde, Tewodros Eshete, Wu, Ai-Min, Xu, Gelin, Yadollahpour, Ali, Yahyazadeh Jabbari, Seyed Hossein, Yamada, Tomohide, Yaseri, Mehdi, Yenesew, Muluken Azage, Yeshaneh, Alex, Yilma, Mekdes Tigistu, Yimer, Ebrahim M, Yip, Paul, Yirsaw, Biruck Desalegn, Yisma, Engida, Yonemoto, Naohiro, Younis, Mustafa Z, Yousof, Hebat-Allah Salah A, Yu, Chuanhua, Yusefzadeh, Hasan, Zamani, Mohammad, Zambrana-Torrelio, Carlos, Zandian, Hamed, Zeleke, Ayalew Jejaw, Zepro, Nejimu Biza, Zewale, Taye Abuhay, Zhang, Dongyu, Zhang, Yunquan, Zhao, Xiu-Ju, Ziapour, Arash, Zodpey, Sanjay, and Hay, Simon I
Abstract: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea.
Published: 2020
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13. The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Kamangar, Farin, Nasrollahzadeh, Dariush, Safiri, Saeid, Sepanlou, Sadaf G, Fitzmaurice, Christina, Ikuta, Kevin S, Bisignano, Catherine, Islami, Farhad, Roshandel, Gholamreza, Lim, Stephen S, Abolhassani, Hassan, Abu-Gharbieh, Eman, Adedoyin, Rufus Adesoji, Advani, Shailesh M, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Akinyemiju, Tomi, Akunna, Chisom Joyqueenet, Alahdab, Fares, Alipour, Vahid, Almasi-Hashiani, Amir, Almulhim, Abdulaziz M, Anber, Nahla Hamed, Ansari-Moghaddam, Alireza, Arabloo, Jalal, Arab-Zozani, Morteza, Awedew, Atalel Fentahun, Badawi, Alaa, Berfield, Kathleen S Sachiko, Berhe, Kidanemaryam, Bhattacharyya, Krittika, Biondi, Antonio, Bjørge, Tone, Borzì, Antonio Maria, Bosetti, Cristina, Carreras, Giulia, Carvalho, Felix, Castro, Clara, Chu, Dinh-Toi, Costa, Vera Marisa, Dagnew, Baye, Darega Gela, Jiregna, Daryani, Ahmad, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Dianatinasab, Mostafa, Elbarazi, Iffat, Emamian, Mohammad Hassan, Etemadi, Arash, Faris, Pawan Sirwan, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Gad, Mohamed M, Gallus, Silvano, Gebre, Abadi Kahsu, Gebrehiwot, Tsegaye Tewelde, Gebremeskel, Gebreamlak Gebremedhn, Gebresillassie, Begashaw Melaku, Ghasemi-kebria, Fatemeh, Ghashghaee, Ahmad, Ghith, Nermin, Golechha, Mahaveer, Gorini, Giuseppe, Gupta, Rahul, Hafezi-Nejad, Nima, Haj-Mirzaian, Arvin, Harvey, James D., Hashemian, Maryam, Hassen, Hamid Yimam, Hay, Simon I, Henok, Andualem, Hoang, Chi Linh, Hosgood, H Dean, Househ, Mowafa, Ilesanmi, Olayinka Stephen, Ilic, Milena D., Irvani, Seyed Sina Naghibi, Jain, Charvi, James, Spencer L, Jee, Sun Ha, Jha, Ravi Prakash, Joukar, Farahnaz, Kabir, Ali, Kasaeian, Amir, Kassaw, Mesfin Wudu, Kaur, Supreet, Kengne, Andre Pascal, Kerboua, Esma, Khader, Yousef Saleh, Khalilov, Rovshan, Khan, Ejaz Ahmad, Khoja, Abdullah T, Kocarnik, Jonathan M, Komaki, Hamidreza, Kumar, Vivek, La Vecchia, Carlo, Lasrado, Savita, Li, Bingyu, Lopez, Alan D, Majeed, Azeem, Manafi, Navid, Manda, Ana Laura, Mansour-Ghanaei, Fariborz, Mathur, Manu Raj, Mehta, Varshil, Mehta, Dhruv, Mendoza, Walter, Mithra, Prasanna, Mohammad, Karzan Abdulmuhsin, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Jemal Abdu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moosavi, Delaram, Moosazadeh, Mahmood, Moradi, Ghobad, Moradpour, Farhad, Moradzadeh, Rahmatollah, Naik, Gurudatta, Negoi, Ionut, Nggada, Haruna Asura, Nguyen, Huong Lan Thi, Nikbakhsh, Rajan, Nixon, Molly R, Olagunju, Andrew T, Olagunju, Tinuke O, Padubidri, Jagadish Rao., Pakshir, Keyvan, Patel, Shanti, Pathak, Mona, Pham, Hai Quang, Pourshams, Akram, Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rafiei, Alireza, Ramezanzadeh, Kiana, Rath, Goura Kishor, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rezaei, Nima, Roro, Elias Merdassa, Saad, Anas M, Salimzadeh, Hamideh, Samy, Abdallah M, Sartorius, Benn, Sarveazad, Arash, Sekerija, Mario, Sha, Feng, Shamsizadeh, Morteza, Sheikhbahaei, Sara, Shirkoohi, Reza, Siddappa Malleshappa, Sudeep K, Singh, Jasvinder A, Sinha, Dhirendra Narain, Smarandache, Catalin-Gabriel, Soshnikov, Sergey, Suleria, Hafiz Ansar Rasul, Tadesse, Degena Bahrey, Tesfay, Berhe Etsay, Thakur, Bhaskar, Traini, Eugenio, Tran, Khanh Bao, Tran, Bach Xuan, Ullah, Irfan, Vacante, Marco, Veisani, Yousef, Vujcic, Isidora S, Weldesamuel, Girmay Teklay, Xu, Rixing, Yazdi-Feyzabadi, Vahid, Yuce, Deniz, Zadnik, Vesna, Zaidi, Zoubida, Zhang, Zhi-Jiang, Malekzadeh, Reza, and Naghavi, Mohsen
Abstract: Oesophageal cancer is a common and often fatal cancer that has two main histological subtypes: oesophageal squamous cell carcinoma and oesophageal adenocarcinoma. Updated statistics on the incidence and mortality of oesophageal cancer, and on the disability-adjusted life-years (DALYs) caused by the disease, can assist policy makers in allocating resources for prevention, treatment, and care of oesophageal cancer. We report the latest estimates of these statistics for 195 countries and territories between 1990 and 2017, by age, sex, and Socio-demographic Index (SDI), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD).
Published: 2020
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14. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017

Author: Yadgir, Simon, Johnson, Catherine Owens, Aboyans, Victor, Adebayo, Oladimeji M., Adedoyin, Rufus Adesoji, Afarideh, Mohsen, Alahdab, Fares, Alashi, Alaa, Alipour, Vahid, Arabloo, Jalal, Azari, Samad, Barthelemy, Celine M., Benziger, Catherine P., Berman, Adam E., Bijani, Ali, Carrero, Juan J., Carvalho, Félix, Daryani, Ahmad, Durães, Andre R., Esteghamati, Alireza, Farid, Talha A., Farzadfar, Farshad, Fernandes, Eduarda, Filip, Irina, Gad, Mohamed M., Hamidi, Samer, Hay, Simon I., Ilesanmi, Olayinka Stephen, Naghibi Irvani, Seyed Sina, Jürisson, Mikk, Kasaeian, Amir, Kengne, Andre Pascal, Khan, Abdur Rahman, Kisa, Adnan, Kisa, Sezer, Kolte, Dhaval, Manafi, Navid, Manafi, Amir, Mensah, George A., Mirrakhimov, Erkin M., Mohammad, Yousef, Mokdad, Ali H., Negoi, Ruxandra Irina, Thi Nguyen, Huong Lan, Nguyen, Trang Huyen, Nixon, Molly R., Otto, Catherine M., Patel, Shanti, Pilgrim, Thomas, Radfar, Amir, Rawaf, David Laith, Rawaf, Salman, Rawasia, Wasiq Faraz, Rezapour, Aziz, Roever, Leonardo, Saad, Anas M., Saadatagah, Seyedmohammad, Senthilkumaran, Subramanian, Sliwa, Karen, Tesfay, Berhe Etsay, Tran, Bach Xuan, Ullah, Irfan, Vaduganathan, Muthiah, Vasankari, Tommi Juhani, Wolfe, Charles D.A., Yonemoto, Naohiro, and Roth, Gregory A.
Abstract: Supplemental Digital Content is available in the text.
Published: 2020
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15. Temporal trends of pancreatic ductal adenocarcinoma in young adults in the United States: A Population-Based Study

Author: Gad, Mohamed M., Saad, Anas M., Al-Husseini, Muneer J., Abdel-Gawad, Youssef M., Alsalhani, Obai M., Alhaddad, Razan, Mohamad, Bashar, Saleh, Mohannad Abou, and Simons-Linares, Carlos Roberto
Abstract: •Pancreatic adenocarcinoma incidence trends have been on the rise in the U.S. general population over the past few decades.•A debate over the specific subpopulation driving the rise exists and the contribution of the young population is controversial.•Our results, largest young population cohort reported to the best of our knowledge, show that incidence trends have been relatively stable in the young population in the U.S. since the year 2000.
Published: 2020
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16. Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017

Author: James, Spencer L, Castle, Chris D, Dingels, Zachary V, Fox, Jack T, Hamilton, Erin B, Liu, Zichen, S Roberts, Nicholas L, Sylte, Dillon O, Henry, Nathaniel J, LeGrand, Kate E, Abdelalim, Ahmed, Abdoli, Amir, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abedi, Aidin, Abosetugn, Akine Eshete, Abushouk, Abdelrahman I, Adebayo, Oladimeji M, Agudelo-Botero, Marcela, Ahmad, Tauseef, Ahmed, Rushdia, Ahmed, Muktar Beshir, Eddine Aichour, Miloud Taki, Alahdab, Fares, Alamene, Genet Melak, Alanezi, Fahad Mashhour, Alebel, Animut, Alema, Niguse Meles, Alghnam, Suliman A, Al-Hajj, Samar, Ali, Beriwan Abdulqadir, Ali, Saqib, Alikhani, Mahtab, Alinia, Cyrus, Alipour, Vahid, Aljunid, Syed Mohamed, Almasi-Hashiani, Amir, Almasri, Nihad A, Altirkawi, Khalid, Abdeldayem Amer, Yasser Sami, Amini, Saeed, Loreche Amit, Arianna Maever, Andrei, Catalina Liliana, Ansari-Moghaddam, Alireza, T Antonio, Carl Abelardo, Yaw Appiah, Seth Christopher, Arabloo, Jalal, Arab-Zozani, Morteza, Arefi, Zohreh, Aremu, Olatunde, Ariani, Filippo, Arora, Amit, Asaad, Malke, Asghari, Babak, Awoke, Nefsu, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Badawi, Alaa, Badiye, Ashish D, Bagli, Eleni, Baig, Atif Amin, Bairwa, Mohan, Bakhtiari, Ahad, Balachandran, Arun, Banach, Maciej, Banerjee, Srikanta K, Banik, Palash Chandra, Banstola, Amrit, Barker-Collo, Suzanne Lyn, Ba¨rnighausen, Till Winfried, Barrero, Lope H, Barzegar, Akbar, Bayati, Mohsen, Baye, Bayisa Abdissa, Bedi, Neeraj, Behzadifar, Masoud, Bekuma, Tariku Tesfaye, Belete, Habte, Benjet, Corina, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Bhardwaj, Pankaj, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bibi, Sadia, Bijani, Ali, Bin Sayeed, Muhammad Shahdaat, Borges, Guilherme, Borzì, Antonio Maria, Boufous, Soufiane, Brazinova, Alexandra, Briko, Nikolay Ivanovich, Budhathoki, Shyam S, Car, Josip, Cárdenas, Rosario, Carvalho, Félix, Castaldelli-Maia, João Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Cerin, Ester, Chandan, Joht S, Chanie, Wagaye Fentahun, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chatziralli, Irini, Chaudhary, Neha, Cho, Daniel Youngwhan, Kabir Chowdhury, Mohiuddin Ahsanul, Chu, Dinh-Toi, Colquhoun, Samantha M, Constantin, Maria-Magdalena, Costa, Vera M, Damiani, Giovanni, Daryani, Ahmad, Dávila-Cervantes, Claudio Alberto, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Derakhshani, Afshin, Deribe, Kebede, Desai, Rupak, Nasab, Mostafa Dianati, da Silva, Diana Dias, Dibaji Forooshani, Zahra Sadat, Doyle, Kerrie E, Driscoll, Tim Robert, Dubljanin, Eleonora, Adema, Bereket Duko, Eagan, Arielle Wilder, Eftekhari, Aziz, Ehsani-Chimeh, Elham, Sayed Zaki, Maysaa El, Elemineh, Demelash Abewa, El-Jaafary, Shaimaa I, El-Khatib, Ziad, Ellingsen, Christian Lycke, Emamian, Mohammad Hassan, Endalew, Daniel Adane, Eskandarieh, Sharareh, Faris, Pawan Sirwan, Faro, Andre, Farzadfar, Farshad, Fatahi, Yousef, Fekadu, Wubalem, Ferede, Tomas Y, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Folayan, Morenike Oluwatoyin, Foroutan, Masoud, Francis, Joel Msafiri, Franklin, Richard Charles, Fukumoto, Takeshi, Geberemariyam, Biniyam Sahiledengle, Gebre, Abadi Kahsu, Gebremedhin, Ketema Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebremichael, Berhe, Gedefaw, Getnet Azeze, Geta, Birhanu, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gill, Tiffany K, Goulart, Alessandra C, Grada, Ayman, Grivna, Michal, Mohialdeen Gubari, Mohammed Ibrahim, Guimarães, Rafael Alves, Guo, Yuming, Gupta, Gaurav, Haagsma, Juanita A, Hafezi-Nejad, Nima, Bidgoli, Hassan Haghparast, Hall, Brian James, Hamadeh, Randah R, Hamidi, Samer, Haro, Josep Maria, Hasan, Md Mehedi, Hasanzadeh, Amir, Hassanipour, Soheil, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hayat, Khezar, Hendrie, Delia, Heydarpour, Fatemeh, Híjar, Martha, Ho, Hung Chak, Hoang, Chi Linh, Hole, Michael K, Holla, Ramesh, Hossain, Naznin, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hu, Guoqing, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena, Ilic, Milena D, Inbaraj, Leeberk Raja, Indriasih, Endang, Naghibi Irvani, Seyed Sina, Shariful Islam, Sheikh Mohammed, Islam, M Mofizul, Ivers, Rebecca Q, Jacobsen, Kathryn H, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Jalilian, Farzad, Jayaraman, Sudha, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, John-Akinola, Yetunde O, Jonas, Jost B, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Ju¨risson, Mikk, Kabir, Ali, Kadel, Rajendra, Kahsay, Amaha, Kalankesh, Leila R, Kalhor, Rohollah, Kamil, Teshome Abegaz, Kanchan, Tanuj, Kapoor, Neeti, Karami, Manoochehr, Kasaeian, Amir, Kassaye, Hagazi Gebremedhin, Kavetskyy, Taras, Kebede, Hafte Kahsay, Keiyoro, Peter Njenga, Kelbore, Abraham Getachew, Kelkay, Bayew, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalid, Nauman, Khalil, Ibrahim A, Khalilov, Rovshan, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Maseer, Khanna, Tripti, Khazaie, Habibolah, Shadmani, Fatemeh Khosravi, Khundkar, Roba, Kiirithio, Daniel N, Kim, Young-Eun, Kim, Daniel, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Komaki, Hamidreza, M Kondlahalli, Shivakumar K, Korshunov, Vladimir Andreevich, Koyanagi, Ai, G Kraemer, Moritz U, Krishan, Kewal, Bicer, Burcu Kucuk, Kugbey, Nuworza, Kumar, Vivek, Kumar, Nithin, Kumar, G Anil, Kumar, Manasi, Kumaresh, Girikumar, Kurmi, Om P, Kuti, Oluwatosin, Vecchia, Carlo La, Lami, Faris Hasan, Lamichhane, Prabhat, Lang, Justin J, Lansingh, Van C, Laryea, Dennis Odai, Lasrado, Savita, Latifi, Arman, Lauriola, Paolo, Leasher, Janet L, Huey Lee, Shaun Wen, Lenjebo, Tsegaye Lolaso, Levi, Miriam, Li, Shanshan, Linn, Shai, Liu, Xuefeng, Lopez, Alan D, Lotufo, Paulo A, Lunevicius, Raimundas, Lyons, Ronan A, Madadin, Mohammed, El Razek, Muhammed Magdy Abd, Mahotra, Narayan Bahadur, Majdan, Marek, Majeed, Azeem, Malagon-Rojas, Jeadran N, Maled, Venkatesh, Malekzadeh, Reza, Malta, Deborah Carvalho, Manafi, Navid, Manafi, Amir, Manda, Ana-Laura, Manjunatha, Narayana, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Maravilla, Joemer C, March, Lyn M, Mason-Jones, Amanda J, Masoumi, Seyedeh Zahra, Massenburg, Benjamin Ballard, Maulik, Pallab K, Meles, Gebrekiros Gebremichael, Melese, Addisu, Melketsedik, Zeleke Aschalew, N Memiah, Peter T, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Meresa Berwo, Mengesha, Melkamu Merid, Meretoja, Tuomo J, Meretoja, Atte, Merie, Hayimro Edemealem, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mini, GK, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei-Alavijeh, Mehdi, Mithra, Prasanna, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Yousef, Mohammad, Karzan Abdulmuhsin, Darwesh, Aso Mohammad, Gholi Mezerji, Naser Mohammad, Mohammadian-Hafshejani, Abdollah, Mohammadoo-Khorasani, Milad, Mohammadpourhodki, Reza, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mohebi, Farnam, Molokhia, Mariam, Monasta, Lorenzo, Moodley, Yoshan, Moosazadeh, Mahmood, Moradi, Masoud, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradpour, Farhad, Morawska, Lidia, Velásquez, Ilais Moreno, Morisaki, Naho, Morrison, Shane Douglas, Mossie, Tilahun Belete, Muluneh, Atalay Goshu, Murthy, Srinivas, Musa, Kamarul Imran, Mustafa, Ghulam, Nabhan, Ashraf F, Nagarajan, Ahamarshan Jayaraman, Naik, Gurudatta, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nascimento, Bruno Ramos, Naserbakht, Morteza, Nayak, Vinod, Ndwandwe, Duduzile Edith, Negoi, Ionut, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Thi Nguyen, Huong Lan, Nikbakhsh, Rajan, Anggraini Ningrum, Dina Nur, Nnaji, Chukwudi A, Nyasulu, Peter S, Ogbo, Felix Akpojene, Oghenetega, Onome Bright, Oh, In-Hwan, Okunga, Emmanuel Wandera, Olagunju, Andrew T, Olagunju, Tinuke O, Bali, Ahmed Omar, Onwujekwe, Obinna E, Asante, Kwaku Oppong, Orpana, Heather M, Ota, Erika, Otstavnov, Nikita, Otstavnov, Stanislav S, A, Mahesh P, Padubidri, Jagadish Rao, Pakhale, Smita, Pakshir, Keyvan, Panda-Jonas, Songhomitra, Park, Eun-Kee, Patel, Sangram Kishor, Pathak, Ashish, Pati, Sanghamitra, Patton, George C, Paulos, Kebreab, Peden, Amy E, Filipino Pepito, Veincent Christian, Pereira, Jeevan, Pham, Hai Quang, Phillips, Michael R, Pinheiro, Marina, Polibin, Roman V, Polinder, Suzanne, Poustchi, Hossein, Prakash, Swayam, Angga Pribadi, Dimas Ria, Puri, Parul, Syed, Zahiruddin Quazi, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafay, Anwar, Rafiee, Ata, Rafiei, Alireza, Rahim, Fakher, Rahimi, Siavash, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ranganathan, Kavitha, Rao, Sowmya J, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Renjith, Vishnu, N Renzaho, Andre M, Resnikoff, Serge, Rezapour, Aziz, Ribeiro, Ana Isabel, Rickard, Jennifer, Rios González, Carlos Miguel, Ronfani, Luca, Roshandel, Gholamreza, Saad, Anas M, Sabde, Yogesh Damodar, Sabour, Siamak, Saddik, Basema, Safari, Saeed, Safari-Faramani, Roya, Safarpour, Hamid, Safdarian, Mahdi, Sajadi, S Mohammad, Salamati, Payman, Salehi, Farkhonde, Zahabi, Saleh Salehi, Rashad Salem, Marwa R, Salem, Hosni, Salman, Omar, Salz, Inbal, Samy, Abdallah M, Sanabria, Juan, Riera, Lidia Sanchez, Santric Milicevic, Milena M, Sarker, Abdur Razzaque, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Sawyer, Susan M, Saxena, Sonia, Sayyah, Mehdi, Schwebel, David C, Seedat, Soraya, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Seyedmousavi, Seyedmojtaba, Sha, Feng, Shaahmadi, Faramarz, Shahabi, Saeed, Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharif-Alhoseini, Mahdi, Sharifi, Hamid, Sheikh, Aziz, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Siabani, Soraya, Sigfusdottir, Inga Dora, Singh, Pankaj Kumar, Singh, Jasvinder A, Sinha, Dhirendra Narain, Smarandache, Catalin-Gabriel, R Smith, Emma U, Soheili, Amin, Soleymani, Bija, Soltanian, Ali Reza, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Stein, Dan J, Stokes, Mark A, Sufiyan, Mu'awiyyah Babale, Rasul Suleria, Hafiz Ansar, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Taddele, Biruk Wogayehu, Tadesse, Degena Bahrey, Tamiru, Animut Tagele, Tarigan, Ingan Ukur, Tefera, Yonatal Mesfin, Tehrani-Banihashemi, Arash, Tekle, Merhawi Gebremedhin, Tekulu, Gebretsadkan Hintsa, Tesema, Ayenew Kassie, Tesfay, Berhe Etsay, Thapar, Rekha, Tilahune, Asres Bedaso, Tlaye, Kenean Getaneh, Tohidinik, Hamid Reza, Topor-Madry, Roman, Tran, Bach Xuan, Tran, Khanh Bao, Tripathy, Jaya Prasad, Tsai, Alexander C, Car, Lorainne Tudor, Ullah, Saif, Ullah, Irfan, Umar, Maida, Unnikrishnan, Bhaskaran, Upadhyay, Era, Uthman, Olalekan A, Valdez, Pascual R, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Waheed, Yasir, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Wiangkham, Taweewat, Wolde, Haileab Fekadu, Woldeyes, Dawit Habte, Wondafrash, Dawit Zewdu, Wondmeneh, Temesgen Gebeyehu, Wondmieneh, Adam Belay, Wu, Ai-Min, Yadav, Rajaram, Yadollahpour, Ali, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, Youm, Yoosik, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Yong, Yu, Chuanhua, Yusefzadeh, Hasan, Moghadam, Telma Zahirian, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zarei, Ahmad, Zare, Fatemeh, Zhang, Zhi-Jiang, Zhang, Yunquan, Zodpey, Sanjay, Dandona, Lalit, Dandona, Rakhi, Degenhardt, Louisa, Dharmaratne, Samath Dhamminda, Hay, Simon I, Mokdad, Ali H, Reiner, Robert C, Sartorius, Benn, and Vos, Theo
Abstract: BackgroundPast research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
Published: 2020
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17. The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017

Author: Etemadi, Arash, Safiri, Saeid, Sepanlou, Sadaf G, Ikuta, Kevin, Bisignano, Catherine, Shakeri, Ramin, Amani, Mohammad, Fitzmaurice, Christina, Nixon, Molly, Abbasi, Nooshin, Abolhassani, Hassan, Advani, Shailesh M, Afarideh, Mohsen, Akinyemiju, Tomi, Alam, Tahiya, Alikhani, Mahtab, Alipour, Vahid, Allen, Christine A, Almasi-Hashiani, Amir, Arabloo, Jalal, Assadi, Reza, Atique, Suleman, Awasthi, Ashish, Bakhtiari, Ahad, Behzadifar, Masoud, Berhe, Kidanemaryam, Bhala, Neeraj, Bijani, Ali, Bin Sayeed, Muhammad Shahdaat, Bjørge, Tone, Borzì, Antonio M, Braithwaite, Dejana, Brenner, Hermann, Carreras, Giulia, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castro, Franz, Chu, Dinh-Toi, Costa, Vera M, Daryani, Ahmad, Davitoiu, Dragos V, Demoz, Gebre T, Demis, Asmamaw B, Denova-Gutiérrez, Edgar, Dey, Subhojit, Dianati Nasab, Mostafa, Djalalinia, Shirin, Emamian, Mohammad Hassan, Farahmand, Mohammad, Fernandes, João C, Fischer, Florian, Foroutan, Masoud, Gad, Mohamed M, Gallus, Silvano, Gebremeskel, Gebreamlak Gebremedhn, Gedefew, Getnet A, Ghaseni-Kebria, Fatemeh, Gorini, Giuseppe, Hafezi-Nejad, Nima, Haj-Mirzaian, Arvin, Haro, Josep M, Harvey, James D, Hasanzadeh, Amir, Hashemian, Maryam, Hassen, Hamid Y, Hay, Simon I, Hidru, Hagos D, Hostiuc, Mihaela, Househ, Mowafa, Ilesanmi, Olayinka s, Ilic, Milena D., Innos, Kaire, Islami, Farhad, James, Spencer L, Jenabi, Ensiyeh, kalhor, Rohollah, Kamangar, Farin, Kasaeian, Amir, Kengne, Andre P, Khader, Yousef S, Khalilov, Rovshan, Khan, Ejaz A, Khan, Gulfaraz, Khayamzadeh, Maryam, Khazaee-Pool, Maryam, Khazaei, Salman, Khoja, Abdullah T, Khosravi Shadmani, Fatemah, Kim, Yun Jin, Kocarnik, Jonathan M, Komaki, Hamidreza, Koyanagi, Ai, Kumar, Vivek, La Vecchia, Carlo, Lopez, Alan D, Lunevicius, Raimundas, Manafi, Navid, Manda, Ana-Laura, Geta, Birhanu, Meheretu, Hailemariam, Mengistu, Getnet, Miazgowski, Bartosz, Mir, Seyed Mostafa, Mohammad, Karzan A, Mohammad Gholi Mezerji, Naser, Mohammadian, Mahdi, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moosazadeh, Mahmood, Moossavi, Maryam, Moradi, Ghobad, Moradpour, Farhad, Moradzadeh, Rahmatollah, Moreno Vel squez, Ilais, Mosapour, Abbas, Naderi, Mehdi, Naik, Gurudatta, Najafi, Farid, Nahvijou, Azin, Negoi, Ionut, Nikbakhsh, Rajan, Nojomi, Marzieh, Olagunju, Andrew T, Olagunju, Tinuke O, Oren, Eyal, Parsian, Hadi, Piccinelli, Cristiano, Pourshams, Akram, Poustchi, Hossein, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahimi, Mahdi, Rahmati, Marveh, Renzaho, Andre M N, Rezaei, Nima, Ribeiro, Ana Isabel, Roshandel, Gholamreza, Saad, Anas M, Saadatagah, Seyedmohammad, Salimzadeh, Hamideh, Samy, Abdallah M, Sanabria, Juan, Santric Milicevic, Milena M, Sarveazad, Arash, Sawhney, Monika, Shaahmadi, Faramarz, Sekerija, Mario, Shaikh, Masood A, Shamshirian, Amir, Siddappa Malleshappa, Sudeep K, Singh, Jasvinder A, Smarandache, Catalin-Gabriel, Soofi, Moslem, Tabuchi, Takahiro, Tadesse, Degena B, Tapak, Leili, Tesfay, Berhe E, Traini, Eugenio, Tran, Bach, Tran, Khanh B, Vacante, Marco, Vahedian-Azimi, Amir, Veisani, Yousef, Vosoughi, Kia, Vujcic, Isidora S, Westerman, Ronny, Wondmieneh, Adam B, Xu, Rixing, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yousefi, Zabihollah, Yousefi, Bhaman, Zahirian Moghadam, Telma, Zaki, Leila, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zarghi, Afshin, Zhang, Zhi-Jiang, Naghavi, Mohsen, and Malekzadeh, Reza
Abstract: Stomach cancer is a major health problem in many countries. Understanding the current burden of stomach cancer and the differential trends across various locations is essential for formulating effective preventive strategies. We report on the incidence, mortality, and disability-adjusted life-years (DALYs) due to stomach cancer in 195 countries and territories from 21 regions between 1990 and 2017.
Published: 2020
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18. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Pourshams, Akram, Sepanlou, Sadaf G, Ikuta, Kevin S, Bisignano, Catherine, Safiri, Saeid, Roshandel, Gholamreza, Sharif, Mehdi, Khatibian, Morteza, Fitzmaurice, Christina, Nixon, Molly R, Abbasi, Nooshin, Afarideh, Mohsen, Ahmadian, Elham, Akinyemiju, Tomi, Alahdab, Fares, Alam, Tahiya, Alipour, Vahid, Allen, Christine A, Anber, Nahla Hamed, Ansari-Moghaddam, Alireza, Arabloo, Jalal, Badawi, Alaa, Bagherzadeh, Mojtaba, Belayneh, Yaschilal Muche, Biadgo, Belete, Bijani, Ali, Biondi, Antonio, Bjørge, Tone, Borzì, Antonio M, Bosetti, Cristina, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Carreras, Giulia, Carvalho, Félix, Choi, Jee-Young J, Chu, Dinh-Toi, Dang, Anh Kim, Daryani, Ahmad, Davitoiu, Dragos Virgil, Demoz, Gebre Teklemariam, Desai, Rupak, Dey, Subhojit, Do, Hoa Thi, Do, Huyen Phuc, Eftekhari, Aziz, Esteghamati, Alireza, Farzadfar, Farshad, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Gad, Mohamed M, Gallus, Silvano, Geta, Birhanu, Gorini, Giuseppe, Hafezi-Nejad, Nima, Harvey, James D, Hasankhani, Milad, Hasanzadeh, Amir, Hassanipour, Soheil, Hay, Simon I, Hidru, Hagos D, Hoang, Chi Linh, Hostiuc, Sorin, Househ, Mowafa, Ilesanmi, Olayinka Stephen, Ilic, Milena D, Irvani, Seyed Sina Naghibi, Jafari Balalami, Nader, James, Spencer L, Joukar, Farahnaz, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kengne, Andre Pascal, Khalilov, Rovshan, Khan, Ejaz Ahmad, Khater, Amir, Khosravi Shadmani, Fatemeh, Kocarnik, Jonathan M, Komaki, Hamidreza, Koyanagi, Ai, Kumar, Vivek, La Vecchia, Carlo, Lopukhov, Platon D, Manafi, Farzad, Manafi, Navid, Manda, Ana-Laura, Mansour-Ghanaei, Fariborz, Mehta, Dhruv, Mehta, Varshil, Meier, Toni, Meles, Hagazi Gebre, Mengistu, Getnet, Miazgowski, Tomasz, Mohamadnejad, Mehdi, Mohammadian-Hafshejani, Abdollah, Mohammadoo-Khorasani, Milad, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moossavi, Maryam, Moradzadeh, Rahmatollah, Naik, Gurudatta, Negoi, Ionut, Nguyen, Cuong Tat, Nguyen, Long Hoang, Nguyen, Trang Huyen, Olagunju, Andrew T, Olagunju, Tinuke O, Pennini, Alyssa, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rahimi, Mahdi, Rath, Goura Kishor, Rawaf, David Laith, Rawaf, Salman, Reiner, Robert C, Rezaei, Nima, Rezapour, Aziz, Saad, Anas M, Saadatagah, Seyedmohammad, Sahebkar, Amirhossein, Salimzadeh, Hamideh, Samy, Abdallah M, Sanabria, Juan, Sarveazad, Arash, Sawhney, Monika, Sekerija, Mario, Shabalkin, Pavel, Shaikh, Masood Ali, Sharma, Rajesh, Sheikhbahaei, Sara, Shirkoohi, Reza, Siddappa Malleshappa, Sudeep K, Sisay, Mekonnen, Soreide, Kjetil, Soshnikov, Sergey, Sotoudehmanesh, Rasoul, Starodubov, Vladimir I, Subart, Michelle L, Tabarés-Seisdedos, Rafael, Tadesse, Degena Bahray Bahrey, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Ullah, Irfan, Vacante, Marco, Vahedian-Azimi, Amir, Varavikova, Elena, Westerman, Ronny, Wondafrash, Dawit Dawit Zewdu, Xu, Rixing, Yonemoto, Naohiro, Zadnik, Vesna, Zhang, Zhi-Jiang, Malekzadeh, Reza, and Naghavi, Mohsen
Abstract: Worldwide, both the incidence and death rates of pancreatic cancer are increasing. Evaluation of pancreatic cancer burden and its global, regional, and national patterns is crucial to policy making and better resource allocation for controlling pancreatic cancer risk factors, developing early detection methods, and providing faster and more effective treatments.
Published: 2019
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19. The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Safiri, Saeid, Sepanlou, Sadaf G, Ikuta, Kevin S, Bisignano, Catherine, Salimzadeh, Hamideh, Delavari, Alireza, Ansari, Reza, Roshandel, Gholamreza, Merat, Shahin, Fitzmaurice, Christina, Force, Lisa M, Nixon, Molly R, Abbastabar, Hedayat, Abegaz, Kedir Hussein, Afarideh, Mohsen, Ahmadi, Ayat, Ahmed, Muktar Beshir, Akinyemiju, Tomi, Alahdab, Fares, Ali, Raghib, Alikhani, Mahtab, Alipour, Vahid, Aljunid, Syed Mohamed, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amini, Saeed, Anber, Nahla Hamed, Ansari-Moghaddam, Alireza, Arabloo, Jalal, Arefi, Zohreh, Asghari Jafarabadi, Mohammad, Azadmehr, Abbas, Badawi, Alaa, Baheiraei, Nafiseh, Bärnighausen, Till Winfried, Basaleem, Huda, Behzadifar, Masoud, Behzadifar, Meysam, Belayneh, Yaschilal Muche, Berhe, Kidanemaryam, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Biondi, Antonio, Bjørge, Tone, Borzì, Antonio M, Bosetti, Cristina, Bou-Orm, Ibrahim R., Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Carreras, Giulia, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Cerin, Ester, Chiang, Peggy Pei-Chia, Chido-Amajuoyi, Onyema Greg, Daryani, Ahmad, Davitoiu, Dragos Virgil, Demoz, Gebre Teklemariam, Desai, Rupak, Dianati nasab, Mostafa, Eftekhari, Aziz, El Sayed, Iman, Elbarazi, Iffat, Emamian, Mohammad Hassan, Endries, Aman Yesuf, Esmaeilzadeh, Firooz, Esteghamati, Alireza, Etemadi, Arash, Farzadfar, Farshad, Fernandes, Eduarda, Fernandes, João C, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Gad, Mohamed M, Gallus, Silvano, Ghaseni-Kebria, Fatemeh, Ghashghaee, Ahmad, Gorini, Giuseppe, Hafezi-Nejad, Nima, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hasanpour-Heidari, Susan, Hasanzadeh, Amir, Hassanipour, Soheil, Hay, Simon I, Hoang, Chi Linh, Hostiuc, Mihaela, Househ, Mowafa, Ilesanmi, Olayinka Stephen, Ilic, Milena D., Innos, Kaire, Irvani, Seyed Sina Naghibi, Islami, Farhad, Jaca, Anelisa, Jafari Balalami, Nader, Jafari delouei, Nastaran, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, James, Spencer L., Javanbakht, Mehdi, Jenabi, Ensiyeh, Jha, Ravi Prakash, Joukar, Farahnaz, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kassaw, Mesfin Wudu, Kengne, Andre Pascal, Khader, Yousef Saleh, Khaksarian, Mojtaba, Khalilov, Rovshan, Khan, Ejaz Ahmad, Khayamzadeh, Maryam, Khazaee-Pool, Maryam, Khazaei, Salman, Khosravi Shadmani, Fatemeh, Khubchandani, Jagdish, Kim, Daniel, Kisa, Adnan, Kisa, Sezer, Kocarnik, Jonathan M, Komaki, Hamidreza, Kopec, Jacek A, Koyanagi, Ai, Kuipers, Ernst J., Kumar, Vivek, La Vecchia, Carlo, Lami, Faris Hasan, Lopez, Alan D, Lopukhov, Platon D, Lunevicius, Raimundas, Majeed, Azeem, Majidinia, Maryam, Manafi, Amir, Manafi, Navid, Manda, Ana-Laura, Mansour-Ghanaei, Fariborz, Mantovani, Lorenzo Giovanni, Mehta, Dhruv, Meier, Toni, Meles, Hagazi Gebre, Mendoza, Walter, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Mir, Seyed Mostafa, Mirzaei, Hamed, Mohammad, Karzan Abdulmuhsin, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadoo-Khorasani, Milad, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moossavi, Maryam, Moradi, Ghobad, Moradpour, Farhad, Moradzadeh, Rahmatollah, Nahvijou, Azin, Naik, Gurudatta, Najafi, Farid, Nazari, Javad, Negoi, Ionut, Nguyen, Cuong Tat, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olagunju, Tinuke O, Pana, Adrian, Pereira, David M., Pirestani, Majid, Pourshams, Akram, Poustchi, Hossein, Qorbani, Mostafa, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rahmati, Marveh, Rajati, Fatemeh, Rawaf, David Laith, Rawaf, Salman, Reiner, Robert C, Renzaho, Andre M N, Rezaei, Nima, Rezapour, Aziz, Saad, Anas M, Saadatagah, Seyedmohammad, Saddik, Basema, Salehi, Farkhonde, Salehi Zahabi, Saleh, Salz, Inbal, Samy, Abdallah M, Sanabria, Juan, Santric Milicevic, Milena M, Sarveazad, Arash, Satpathy, Maheswar, Schneider, Ione J C, Sekerija, Mario, Shaahmadi, Faramarz, Shabaninejad, Hosein, Shamsizadeh, Morteza, Sharafi, Zeinab, Sharif, Mehdi, Sharifi, Amrollah, Sheikhbahaei, Sara, Shirkoohi, Reza, Siddappa Malleshappa, Sudeep K, Silva, Diego Augusto Santos, Sisay, Mekonnen, Smarandache, Catalin-Gabriel, Soofi, Moslem, Soreide, Kjetil, Soshnikov, Sergey, Starodubov, Vladimir I., Subart, Michelle L., Sullman, Mark JM, Tabarés-Seisdedos, Rafael, Taherkhani, Amir, Tesfay, Berhe etsay, Topor-Madry, Roman, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Ullah, Irfan, Uthman, Olalekan A, Vacante, Marco, Vahedian-Azimi, Amir, Valli, Alessandro, Varavikova, Elena, Vujcic, Isidora S, Westerman, Ronny, Yazdi-Feyzabadi, Vahid, Yisma, Engida, Yu, Chuanhua, Zadnik, Vesna, Zahirian Moghadam, Telma, Zaki, Leila, Zandian, Hamed, Zhang, Zhi-Jiang, Murray, Christopher J L, Naghavi, Mohsen, and Malekzadeh, Reza
Abstract: Data about the global, regional, and country-specific variations in the levels and trends of colorectal cancer are required to understand the impact of this disease and the trends in its burden to help policy makers allocate resources. Here we provide a status report on the incidence, mortality, and disability caused by colorectal cancer in 195 countries and territories between 1990 and 2017.
Published: 2019
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20. Risk and survival of chronic myeloid leukemia after breast cancer: A population-based study.

Author: Al-Husseini, Muneer J., Mohamed, Hadeer H., Saad, Anas M., Gad, Mohamed M., Atia, Mona, Qaddoora, Umniyah, Abushouk, Abdelrahman Ibrahim, and El-Shinawi, Mohamed
Subjects: BREAST cancer patients, CHRONIC myeloid leukemia, CANCER complications, CANCER chemotherapy, CANCER radiotherapy
Abstract: We aimed to investigate the risk and survival of chronic myeloid leukemia (CML) after breast cancer (BC) diagnosis. We used the Surveillance, Epidemiology, and End Results 'SEER' database. Females, diagnosed with BC between 1992 and 2014, were selected and followed for the development of CML after a 6-month latency period from BC diagnosis. We used the Multiple Primary Standardized Incidence Ratios session of the SEER*Stat software (version 8.3.4) to calculate the Observed/Expected (O/E) ratios with 95% confidence intervals (CI). To calculate the overall survival, we performed an unadjusted Kaplan-Meier analysis using the SPSS software. We included 474,866 females with BC, of which 178 were later diagnosed with CML. We found the risk of CML to increase significantly after BC diagnosis (O/E = 1.26, 95% CI: 1.08-1.45) and the risk was specifically higher within the first 5 years of diagnosis (O/E = 1.45, 95% CI: 1.16-1.8). When the risk was stratified by cancer stage, localized BC was associated with a significant increase in CML risk within 5 years of diagnosis (O/E = 1.4, 95% CI: 1.06-1.82), while regional BC was associated with a significant increase in CML risk after more than 5 years of diagnosis (O/E = 1.59, 95% CI: 1.09-2.25). Moreover, radiotherapy, chemotherapy, and presence of hormonal receptors were associated with a significant increase in CML risk in BC patients. The median overall survival of CML after BC was 28 months. Breast cancer patients have an increased risk of developing CML and further investigation is required to establish the causes of this finding. [ABSTRACT FROM AUTHOR]
Published: 2019
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21. Impact of Hospital Procedural Volume on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve.

Author: Kassis, Nicholas, Saad, Anas M., Hariri, Essa, Gad, Mohamed M., Abdelfattah, Omar M., Yun, James J., Reed, Grant W., Puri, Rishi, Krishnaswamy, Amar, and Kapadia, Samir R.
Published: 2020
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22. Initial systemic chemotherapeutic and targeted therapy strategies for the treatment of colorectal cancer patients with liver metastases

Author: Saad, Anas M and Abdel-Rahman, Omar
Abstract: ABSTRACTIntroduction: The liver is the most common metastatic site in colorectal cancer with more than half the patients developing a liver metastasis either at the time of their diagnosis (synchronous) or later (metachronous). Surgical resection remains the principal curative approach that offers significant survival improvements. However, upfront surgery is only possible in about 10–20% of patients at the time of diagnosis, making the consideration of other treatment modalities essential.Areas covered: In this review, the authors provide an overview of the standard approaches for the initial management of patients with colorectal cancer with liver metastases. They then provide an up-to-date discussion of first-line systemic chemotherapy/targeted therapy options in the contexts of initially resectable and unresectable disease and review toxicities and complications following these options.Expert opinion: Advances in chemotherapeutic agents and biological targeted therapies have improved the prognosis of colorectal cancer with liver metastases. However, there is still no ‘single best approach’, making further trials necessary to provide more evidence.
Published: 2019
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23. Trends in Clinical Characteristics and Outcomes in ST-Elevation Myocardial Infarction Hospitalizations in the United States, 2002-2016.

Author: Ahuja, Keerat Rai, Saad, Anas M., Nazir, Salik, Ariss, Robert W., Shekhar, Shashank, Isogai, Toshiaki, Kassis, Nicholas, Mahmood, Asif, Sheikh, Mujeeb, and Kapadia, Samir R.
Abstract: ST-segment Elevation Myocardial Infarction (STEMI) remains a major modern-day public health problem. We aimed to assess the demographic trends in STEMI related hospitalizations in the United States over a period of fifteen years. The nationwide inpatient sample was queried to obtain information of patients hospitalized with STEMI from January 1, 2002, to December 31, 2016. Annual hospitalization rates were calculated and annual percentage change (APC) was evaluated using regression analysis. A total of 4,121,155 eligible patients were included in this analysis. Overall, the total number of STEMI hospitalization decreased from 421,043 in 2002 to 208,510 in 2016 (P-trend <0.01). With the decreasing trend, the rate was relatively higher among males as compared to females, whites as compared to non-whites, and lower as compared to high socioeconomic status (SES). The rate of PCI in STEMI patients increased from 32.8% in 2002 to 67.8% in 2016 (APC = 5.392%, 95% CI [4.384-6.411], P < 0.001), but was higher among males as compared to females, urban as compared to rural hospitals and higher as compared to lower SES. In-hospital mortality decreased from 11% in 2002 to 10.5% in 2016 (APC = -0.771%, 95% CI [-1.230 to -0.311], P = 0.003), but remained higher among females, rural hospitals and low SES as compared to their correspondent groups. Among STEMI patients, the prevalence of individual comorbidities was noted to be increasing over the study period. Although there has been a declining trend in the number of STEMI hospitalizations, patients with modifiable risk factors presenting with STEMI has been on the rise. Females, rural communities and lower SES groups need special attention because of greater vulnerability. [ABSTRACT FROM AUTHOR]
Published: 2022
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24. Short-Term Outcomes Following Urgent Transcatheter Edge-to-Edge Repair With MitraClip in Cardiogenic Shock: A Population-Based Analysis.

Author: Farwati, Medhat, Saad, Anas M., Abushouk, Abdelrahman Ibrahim, Bansal, Agam, Gad, Mohamed M., Krishnaswamy, Amar, Yun, James, and Kapadia, Samir
Published: 2021
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25. Conduction Disturbance, Pacemaker Rates, and Hospital Length of Stay Following Transcatheter Aortic Valve Implantation with the Sapien 3 Valve

Author: Isogai, Toshiaki, Shekhar, Shashank, Saad, Anas M., Abdelfattah, Omar M., Tarakji, Khaldoun G., Wazni, Oussama M., Kalra, Ankur, Yun, James J., Krishnaswamy, Amar, Reed, Grant W., Kapadia, Samir R., and Puri, Rishi
Abstract: In the absence of randomized data, an expert panel recently proposed an algorithm for conduction disturbance management in transcatheter aortic valve implantation (TAVI) recipients. However, external validations of its recommendations are limited.
Published: 2022
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26. Risk Stratification and Management of Advanced Conduction Disturbances Following TAVI in Patients With Pre-Existing RBBB

Author: Isogai, Toshiaki, Dykun, Iryna, Agrawal, Ankit, Shekhar, Shashank, Saad, Anas M., Verma, Beni Rai, Abdelfattah, Omar M., Kalra, Ankur, Krishnaswamy, Amar, Reed, Grant W., Kapadia, Samir R., and Puri, Rishi
Abstract: Pre-existing right bundle branch block (RBBB) is a strong predictor of increased need for a permanent pacemaker (PPM) following transcatheter aortic valve implantation (TAVI). Yet, further risk stratification and management remain challenging in patients with pre-existing RBBB owing to limited data. Therefore, we sought to investigate the incidence, predictors, and management of advanced conduction disturbances after TAVI in patients with pre-existing RBBB.
Published: 2022
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27. Abstract 11507: Radiation Reduction in Catheterization Laboratory: Single Center Experience

Author: Shekhar, Shashank, Ajay, Abhishek, Kumar, Anirudh, Kaur, Manpreet, Isogai, Toshiaki, Saad, Anas M, Abushouk, Abdelrahman, Abdelfattah, Omar M, Lak, Hassan Mehmood, Farwati, Medhat, Wunderle, Kevin, Ellis, Stephen G, Khatri, Jaikirshan, Krishnaswamy, Amar, and Kapadia, Samir R
Abstract: Introduction:Radiation reduction measures were incorporated in the Cleveland Clinic Catheterization laboratories to mitigate the hazards from radiation exposure to patients and personnel during diagnostic and interventional coronary procedures. We report our experience with these improved systems over a 10-year period.Methods:Fluoroscopes were modified in 2013 by reducing the default fluoroscopic pulse rate from 10 to 7.5 pules/s, added default low-dose acquisitions, revised field-of-view dose factors, and instructed operators to use larger fields-of-view with appropriate collimation. A retrospective data analysis of all patients undergoing diagnostic catheterization from 2009 to 2012 (pre-initiative group), and 2013 to 2019 (post-initiative group) was done using Siemens CARE analytics software. The effectiveness of radiation reduction measures was assessed by comparing the total air kerma (Ka,r), and fluoroscopy- and acquisition-mode air kerma in patients in the two groups after propensity matching them based on age, sex, BSA, and total fluoroscopic time.Results:The total fluoroscopic time for the pre-initiative group (N=18,181) was 8.02 seconds while that for the post-initiative group (N=25,868) was 8.05 seconds. After matching 18,181 patients in both the groups (mean age, 64 years; 62% males), a significant reduction (54.4%) in the mean Ka,rwas observed in the post- in comparison to the pre-initiative group (420.94 mGy vs. 921.21 mGy; p<2.2e-16). Further analysis revealed a reduction in the mean acquisition- (59.3%; 217.33 mGy vs. 533.50 mGy; p<2.2e-16) and fluoroscopy-mode (47.5%; 203.61 mGy vs. 387.71 mGy; p<2.2e-16) air kerma in the post-initiative group. A sub-analysis of patients matched on the basis of their exact fluoroscopy and acquisition times also revealed a significant reduction in Ka,r, acquisition- and fluoroscopy-mode air kerma in the post-initiative group relative to the pre-initiative group (43.95%, 44.04%, 43.78% respectively).Conclusions:Optimization of imaging systems can significantly reduce patient radiation exposures which directly affect the radiation exposure of the Cath lab personnel. Similar algorithms can be applied in other labs to achieve a reduction in radiation exposure.
Published: 2021
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28. Abstract 11938: Mechanisms of Significant Functional Tricuspid Regurgitation in Pulmonary Arterial Hypertension

Author: Kassis, Nicholas, Layoun, Habib, Goyal, Amit, Dong, Tiffany, Saad, Anas M, Puri, Rishi, Heresi, Gustavo A, Tonelli, Adriano, Kapadia, Samir R, and Harb, Serge C
Abstract: Introduction:The relationship between pulmonary arterial hypertension (PAH) and secondary (or functional) tricuspid regurgitation (STR) is well-established, and the simultaneous presence of both conditions portends particularly poor outcomes. Yet not all patients with PAH develop significant STR, and the mechanisms underlying this phenomenon remain unclear.Methods:From the Cleveland Clinic Pulmonary Hypertension Registry, patients diagnosed with PAH between 2007-2013 were included. STR, defined by absent primary tricuspid valve disease on transthoracic echocardiogram (TTE), was considered significant if ≥moderate in severity (≥2+ grade) on TTE. Right-sided chambers, annular, and valvular anatomic and functional characteristics by cardiac computed tomography and TTE were compared between patients with significant vs. nonsignificant STR.Results:Among 88 included patients, 52 had significant STR. The median age was 57 years, and 78% were female. No differences were observed in all baseline clinical characteristics between groups. Relative to those with nonsignificant STR, patients with significant STR had worse right ventricular (RV) dysfunction as evidenced by lower tricuspid annular planar systolic excursion [1.5 (1.3,1.7) vs 2.1 (1.7,2.4); p=0.02] and fractional area change, and worse RV global longitudinal strain and RV free wall strain. Significant STR was further associated with increased RV sphericity as denoted by a smaller sphericity index [1.8 (1.6,2.1) vs. 2 (1.7,2.5); p=0.004], with similar annular dimensions and shape, mural and septal leaflets’ length and angle, and tenting height.Conclusion:Anatomic and functional alterations in the RV rather than in the tricuspid valve are implicated in the development of STR in patients with PAH. The underlying mechanism may be linked to RV dyfunction and remodeling, via increasing RV size and sphericity.
Published: 2021
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29. Causes of Death Among Patients With Metastatic Prostate Cancer in the US From 2000 to 2016

Author: Elmehrath, Ahmed O., Afifi, Ahmed M., Al-Husseini, Muneer J., Saad, Anas M., Wilson, Nathaniel, Shohdy, Kyrillus S., Pilie, Patrick, Sonbol, Mohamad Bassam, and Alhalabi, Omar
Abstract: IMPORTANCE: Owing to improved survival among US patients with prostate cancer (PC), patients tend to live long enough after a PC diagnosis for non–cancer-related comorbidities to be associated with their overall survival. Although studies have investigated causes of death among patients with localized PC, data are lacking regarding causes of death among patients with metastatic PC. OBJECTIVE: To assess causes of death among US patients with metastatic PC from 2000 to 2016. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used data from the Surveillance, Epidemiology, and End Results Program database to analyze a sample of 26?168 US men who received a diagnosis of metastatic PC from January 1, 2000, to December 31, 2016. Data were analyzed from February 2 to July 28, 2020. EXPOSURE: Diagnosis of metastatic PC. MAIN OUTCOMES AND MEASURES: Standardized mortality ratios (SMRs) for different causes of death were calculated by dividing the observed number of deaths from each cause of death by the expected number of deaths in the age-matched US male population for the same period, adjusting for age and race/ethnicity. RESULTS: Of 26?168 patients with metastatic PC included in the analysis, 48.9% were aged 50 to 70 years (mean age at diagnosis, 70.83 years); 74.5% were White individuals, and 72.7% received a diagnosis of stage M1b metastatic PC. A total of 16?732 patients (63.9%) died during the follow-up period. The mean age at death was 74.13 years. Most deaths (59.0%) occurred within the latency period of 2 years after diagnosis of metastatic PC, whereas 31.6% occurred 2 to 5 years after diagnosis and 9.4% occurred more than 5 years after diagnosis. Of the total deaths, 13?011 (77.8%) were from PC, 924 (5.5%) were from other cancers, and 2797 (16.7%) were from noncancer causes. During all latency periods, the most common noncancer causes of death were cardiovascular diseases (SMR, 1.34; 95% CI, 1.26-1.42), chronic obstructive pulmonary disease (SMR, 1.19; 95% CI, 1.03-1.36), and cerebrovascular diseases (SMR, 1.31; 95% CI, 1.13-1.50). CONCLUSIONS AND RELEVANCE: In this cohort study, deaths from noncancer causes, including cardiovascular disease, constituted a substantial number of deaths among men with metastatic PC. Therapy and follow-up should be tailored to the needs of each patient with metastatic PC, and counseling regarding future health risks should be provided.
Published: 2021
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30. The risk of melanoma in patients with chronic lymphocytic leukemia; a population-based study.

Author: Turk, Tarek, Saad, Anas M., Al-Husseini, Muneer J., and Gad, Mohamed M.
Subjects: CHRONIC lymphocytic leukemia, CANCER
Abstract: Introduction: Melanoma is a highly malignant tumor that has been repeatedly reported in chronic lymphocytic leukemia (CLL) patients. We aim to assess the epidemiologic characteristics of this association and emphasize the importance of carefully approaching such cases. Methods: Patients who were diagnosed with CLL between 2000 and 2015 and registered in the Surveillance, Epidemiology and End Results (SEER) database of the US National Cancer Institute were identified using the SEER*stat software (version 8.3.5). The Multiple Primary Standardized Incidence Ratios session of the SEER*stat software (version 8.3.5) was used to calculate the observed/expected (O/E) ratios of melanoma. Results: 48,876 CLL cases were reviewed, of which 474 developed a second primary melanoma of the skin. O/E ratio was 2.07 (95% CI 1.89-2.27), and excess risk was 9.7 per 10,000. The increase in melanoma risk was higher within the first 5 years following CLL diagnosis; O/E = 2.22 (95% CI 1.56-2.14) and excess risk was 10.43 per 10,000. It was higher in males compared to females O/E was 2.10 (95% CI 1.89-2.33) and 1.98 (95% CI 1.62-2.40) in males and females, respectively, and in people aged 45-64; O/E = 2.30 (95% CI 1.95-2.70). Out of 7827 CLL patients receiving chemotherapy, 70 later developed melanoma with a significant O/E of 2.28 (95% CI 1.77-2.88) and an excess risk of 10.66 per 10,000. Conclusion: CLL increases the risk of developing melanoma, especially within 5 years of the diagnosis, and in white males aged between 45-64 years. It is crucial to keep rigorous screening, high-suspicion and close follow-up for recurrence in consideration while managing these patients. [ABSTRACT FROM AUTHOR]
Published: 2020
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31. Abstract P869: Racial Disparities in Pregnancy-Associated Stroke, a US Nationwide Cohort Study

Author: Gad, Mohamed M, Abdeldayem, Jasmin, Abdelfattah, Omar M, Saad, Anas M, Mahmoud, Ahmed M, and Elgendy, Islam Y
Abstract: Introduction:Pregnancy-associated stroke (PAS) is a rare event but is associated with high morbidity and mortality. Understanding racial disparities in outcomes may help improve care in susceptible populations and shed light on areas of possible targeted improvement.Methods:Pregnant and post-partum women hospitalized from January 2002 to December 2017 were identified from the Nationwide Inpatient Sample. White and Black women were included in the current study. PAS was identified using the International Classification of Diseases (ICD) 9 and 10 revisions. In-hospital mortality was the primary outcome. Multivariate regression analysis was used for Adjusted Odds Ratio (aOR) and 95% Confidence Interval (CI) to adjust for differences in baseline and pregnancy-related comorbidities.Results:Among 38,797,752 pregnant and post-partum women, 21.9% were black. A total of 10,959 women (0.03%) suffered from PAS. Of women with PAS, 4,521 (41.3%) were Black. Black women with PAS had a higher in-hospital mortality rate compared to white women (7.8% vs. 5.0%, P< 0.001). A significant disparity was noted in the risk of mortality by age groups where black women of ages 18-24 with PAS had a higher aOR of mortality 2.10, 95% (confidence interval) CI (1.88-2.35) compared to white women, ages 25-29 had aOR of 2.75, 95% CI (2.46-3.07), ages 30-34 had aOR of 3.94, 95% CI (3.50-4.43), ages 35-40 had aOR of 3.73, 95% CI (3.25-4.29), and ages 40 and older had aOR of 1.27, 95% CI (1.08-1.51). A significant difference was noted when stratifying outcome by income as black women in the lowest quartile of income had an aOR of 1.91, 95% CI (1.74-2.10), while those in the highest quartile of income had OR of 2.38, 95% CI (2.02-2.80).Conclusions:Black women with PAS were associated with higher in-hospital mortality compared with the White counterparts. These differences were observed mainly among the younger age groups. Targeted interventions are needed to minimize these observed racial differences.
Published: 2021
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32. Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

Author: Galles, Natalie C, Liu, Patrick Y, Updike, Rachel L, Fullman, Nancy, Nguyen, Jason, Rolfe, Sam, Sbarra, Alyssa N, Schipp, Megan F, Marks, Ashley, Abady, Gdiom Gebreheat, Abbas, Kaja M, Abbasi, Sumra Wajid, Abbastabar, Hedayat, Abd-Allah, Foad, Abdoli, Amir, Abolhassani, Hassan, Abosetugn, Akine Eshete, Adabi, Maryam, Adamu, Abdu A, Adetokunboh, Olatunji O, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afzal, Saira, Aghamir, Seyed Mohammad Kazem, Ahinkorah, Bright Opoku, Ahmad, Sohail, Ahmad, Tauseef, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Ahmed Salih, Yusra, Akalu, Yonas, Aklilu, Addis, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Albano, Luciana, Alemayehu, Yosef, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhassan, Robert Kaba, Ali, Liaqat, Aljunid, Syed Mohamed, Almustanyir, Sami, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amu, Hubert, Andrei, Catalina Liliana, Andrei, Tudorel, Ansar, Adnan, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antony, Benny, Arabloo, Jalal, Arab-Zozani, Morteza, Artanti, Kurnia Dwi, Arulappan, Judie, Awan, Asma Tahir, Awoke, Mamaru Ayenew, Ayza, Muluken Altaye, Azarian, Ghasem, Azzam, Ahmed Y, B, Darshan B, Babar, Zaheer-Ud-Din, Balakrishnan, Senthilkumar, Banach, Maciej, Bante, Simachew Animen, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Barrow, Amadou, Bassat, Quique, Bayarmagnai, Narantuya, Bejarano Ramirez, Diana Fernanda, Bekuma, Tariku Tesfaye, Belay, Habtamu Gebrehana, Belgaumi, Uzma Iqbal, Bhagavathula, Akshaya Srikanth, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharyya, Krittika, Bibi, Sadia, Bijani, Ali, Biondi, Antonio, Boloor, Archith, Braithwaite, Dejana, Buonsenso, Danilo, Butt, Zahid A, Camargos, Paulo, Carreras, Giulia, Carvalho, Felix, Castañeda-Orjuela, Carlos A, Chakinala, Raja Chandra, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chowdhury, Fazle Rabbi, Christopher, Devasahayam J, Chu, Dinh-Toi, Chung, Sheng-Chia, Cortesi, Paolo Angelo, Costa, Vera Marisa, Couto, Rosa A S, Dadras, Omid, Dagnew, Amare Belachew, Dagnew, Baye, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, De Neve, Jan-Walter, Derbew Molla, Meseret, Derseh, Behailu Tariku, Desai, Rupak, Desta, Abebaw Alemayehu, Dhamnetiya, Deepak, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Dorostkar, Fariba, Edem, Bassey, Edinur, Hisham Atan, Eftekharzadeh, Sahar, El Sayed, Iman, El Sayed Zaki, Maysaa, Elhadi, Muhammed, El-Jaafary, Shaimaa I, Elsharkawy, Aisha, Enany, Shymaa, Erkhembayar, Ryenchindorj, Esezobor, Christopher Imokhuede, Eskandarieh, Sharareh, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Fares, Jawad, Faris, Pawan Sirwan, Feleke, Berhanu Elfu, Ferede, Tomas Y, Fernandes, Eduarda, Fernandes, João C, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Francis, Mark Rohit, Fukumoto, Takeshi, Gad, Mohamed M, Gaidhane, Shilpa, Gallus, Silvano, Garg, Tushar, Geberemariyam, Biniyam Sahiledengle, Gebre, Teshome, Gebregiorgis, Birhan Gebresillassie, Gebremedhin, Ketema Bizuwork, Gebremichael, Berhe, Gessner, Bradford D, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghashghaee, Ahmad, Gilani, Syed Amir, Glăvan, Ionela-Roxana, Glushkova, Ekaterina Vladimirovna, Golechha, Mahaveer, Gonfa, Kebebe Bekele, Gopalani, Sameer Vali, Goudarzi, Houman, Gubari, Mohammed Ibrahim Mohialdeen, Guo, Yuming, Gupta, Veer Bala, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Haeuser, Emily, Halwani, Rabih, Hamidi, Samer, Hanif, Asif, Haque, Shafiul, Harapan, Harapan, Hargono, Arief, Hashi, Abdiwahab, Hassan, Shoaib, Hassanein, Mohamed H, Hassanipour, Soheil, Hassankhani, Hadi, Hay, Simon I, Hayat, Khezar, Hegazy, Mohamed I, Heidari, Golnaz, Hezam, Kamal, Holla, Ramesh, Hoque, Mohammad Enamul, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Househ, Mowafa, Hsieh, Vivian Chia-rong, Huang, Junjie, Humayun, Ayesha, Hussain, Rabia, Hussein, Nawfal R, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inamdar, Sumant, Iqbal, Usman, Irham, Lalu Muhammad, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, Itumalla, Ramaiah, Jha, Ravi Prakash, Joukar, Farahnaz, Kabir, Ali, Kabir, Zubair, Kalhor, Rohollah, Kamal, Zul, Kamande, Stanley M, Kandel, Himal, Karch, André, Kassahun, Getinet, Kassebaum, Nicholas J, Katoto, Patrick DMC, Kelkay, Bayew, Kengne, Andre Pascal, Khader, Yousef Saleh, Khajuria, Himanshu, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Junaid, Khan, Maseer, Khan, Moien AB, Khang, Young-Ho, Khoja, Abdullah T, Khubchandani, Jagdish, Kim, Gyu Ri, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kuate Defo, Barthelemy, Kulkarni, Vaman, Kumar, Avinash, Kumar, G Anil, Kumar, Nithin, Kwarteng, Alexander, La Vecchia, Carlo, Lami, Faris Hasan, Landires, Iván, Lasrado, Savita, Lassi, Zohra S, Lee, Hankil, Lee, Yeong Yeh, Levi, Miriam, Lewycka, Sonia, Li, Shanshan, Liu, Xuefeng, Lobo, Stany W, Lopukhov, Platon D, Lozano, Rafael, Lutzky Saute, Ricardo, Magdy Abd El Razek, Muhammed, Makki, Alaa, Malik, Ahmad Azam, Mansour-Ghanaei, Fariborz, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martins-Melo, Francisco Rogerlândio, Matthews, Philippa C, Medina, John Robert Carabeo, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Meretoja, Tuomo J, Mersha, Amanual Getnet, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Miazgowski, Bartosz, Milne, George J, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Hamid Reza, Misra, Sanjeev, Mithra, Prasanna, Moghadaszadeh, Masoud, Mohamed, Teroj Abdulrahman, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Arif, Mohammed, Shafiu, Mohapatra, Archisman, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Montasir, Ahmed Al, Moore, Catrin E, Moradi, Ghobad, Moradzadeh, Rahmatollah, Moraga, Paula, Mueller, Ulrich Otto, Munro, Sandra B, Naghavi, Mohsen, Naimzada, Mukhammad David, Naveed, Muhammad, Nayak, Biswa Prakash, Negoi, Ionut, Neupane Kandel, Sandhya, Nguyen, Trang Huyen, Nikbakhsh, Rajan, Ningrum, Dina Nur Anggraini, Nixon, Molly R, Nnaji, Chukwudi A, Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Ochir, Chimedsuren, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Onwujekwe, Obinna E, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakshir, Keyvan, Park, Eun-Cheol, Pashazadeh Kan, Fatemeh, Pathak, Mona, Paudel, Rajan, Pawar, Shrikant, Pereira, Jeevan, Peres, Mario F P, Perianayagam, Arokiasamy, Pinheiro, Marina, Pirestani, Majid, Podder, Vivek, Polibin, Roman V, Pollok, Richard Charles G, Postma, Maarten J, Pottoo, Faheem Hyder, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahimi-Movaghar, Vafa, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmawaty, Setyaningrum, Rajesh, Aashish, Ramshaw, Rebecca E, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Sowmya J, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre M N, Rezaei, Negar, Rezai, Mohammad Sadegh, Rios-Blancas, Maria, Rogowski, Emma L B, Ronfani, Luca, Rwegerera, Godfrey M, Saad, Anas M, Sabour, Siamak, Saddik, Basema, Saeb, Mohammad Reza, Saeed, Umar, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salam, Nasir, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M, Sanabria, Juan, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sawhney, Monika, Saxena, Deepak, Saxena, Sonia, Seidu, Abdul-Aziz, Seylani, Allen, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shetty, Pavanchand H, Shigematsu, Mika, Shin, Jae Il, Sidemo, Negussie Boti, Singh, Ambrish, Singh, Jasvinder A, Sinha, Smriti, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soheili, Amin, Tadesse, Eyayou Girma, Tamiru, Animut Tagele, Tan, Ker-Kan, Tekalegn, Yohannes, Temsah, Mohamad-Hani, Thakur, Bhaskar, Thapar, Rekha, Thavamani, Aravind, Tobe-Gai, Ruoyan, Tohidinik, Hamid Reza, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tripathi, Manjari, Tsegaye, Berhan, Tsegaye, Gebiyaw Wudie, Ullah, Anayat, Ullah, Saif, Ullah, Sana, Unim, Brigid, Vacante, Marco, Velazquez, Diana Zuleika, Vo, Bay, Vollmer, Sebastian, Vu, Giang Thu, Vu, Linh Gia, Waheed, Yasir, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Yiğit, Vahit, Yirdaw, Birhanu Wubale, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zamani, Mohammad, Zamanian, Maryam, Zewdie, Dejene Tesfaye, Zhang, Zhi-Jiang, Zhong, Chenwen, Zumla, Alimuddin, Murray, Christopher J L, Lim, Stephen S, and Mosser, Jonathan F
Abstract: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time.
Published: 2021
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33. Abstract 13768: Impact of Socioeconomic Status on 30-Day Readmission Risk in Young Patients With First Acute Myocardial Infarction: A Population-Based Cohort Study

Author: Gad, Mohamed M, Saad, Anas M, Ahuja, Keerat Rai, Bazarbashi, Najdat, Karrthik, Antonette, Kaur, Manpreet, Kaur, Simrat, Sammour, Yasser, Chahine, Johnny, Kadri, Amer, and kapadia, Samir R
Abstract: Introduction:Socioeconomic status (SES) has been correlated with cardiovascular disease and myocardial infarctions in numerous studies.Aim:We aim to understand the relationship between SES and the outcomes of the first acute myocardial infarction (AMI) in young patients with no history of cardiac disease.Methods:Patients who were hospitalized with a primary diagnosis of AMI between January 2011 to August 2015 were identified retrospectively in the Nationwide Readmission Database (NRD). Only adult patients who survived to discharge were included in the current study. Patients older than 60 years or those with a prior history of myocardial infarctions, stroke, or coronary artery disease were excluded. Patients were subdivided based on the median household income into an above median (higher income) group and a below median (lower income) group. Continuous variables were expressed as means +/- standard deviation or median (IQR), and categorical variables were expressed as percentages. All statistical tests were two-sided.Results:A total of 87,664 patients with a mean age of 49.6 +/- 8.2 years, were identified and included in the analysis. Males were about 64.1% of patients, and 58.3% of patients fell in the lower income group. Lower-income patients had higher rates of diabetes; 21.6% in lower-income vs. 17.8% in higher-income, p-value<0.001, hypertension; 59.7% vs. 54.0%, p-value<0.001, obesity; 22.0% vs, 20.0%, p-value<0.001, renal failure; 7.4% vs. 5.1%, p-value<0.001, smoking; 55.2% vs. 46.0%, p-value<0.001, and drug abuse; 8.6% vs. 5.2%, p-value<0.001. The median length of stay in the index admission was similar in both groups; 2 days (2-4) in the lower income patients, and 2 days (2-3) in the higher income patients. However, the 30-day readmission rate was significantly higher in the lower income group, 10.2% vs. 8.3%, p-value<0.001. The most common cause of readmission was re-infarction.Conclusions:More young adults who develop an acute myocardial infarction are from lower socioeconomic status, and those have a higher risk of readmission to the hospital within 30 days of discharge. Many factors might contribute to this disparity and further studies should evaluate how to improve outcomes in the lower income patients.
Published: 2019
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34. Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Author: Saad, Anas M., Gad, Mohamed M., Al-Husseini, Muneer J., Ruhban, Inas A., Sonbol, Mohamad Bassam, and Ho, Thai H.
Abstract: Renal-cell carcinoma (RCC) is one of the common malignancies in the United States. RCC incidence and mortality have been changing for many reasons. We performed a thorough investigation of incidence and mortality trends of RCC in the United States using the cell Surveillance, Epidemiology, and End Results (SEER) database.
Published: 2019
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34 results on '"Saad, Anas M"'

1. Impact of perioperative chemotherapy on survival outcomes among patients with metastatic colorectal cancer to the liver

2. The Association of Chronic Kidney Disease With Outcomes Following Percutaneous Left Atrial Appendage Closure.

3. Supplemental calcium and vitamin D and long-term mortality in aortic stenosis

4. Takotsubo syndrome: Does "Diabetes Paradox" exist?

5. Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990–2050

6. Prognostic and predictive value of microsatellite instability status among patients with colorectal cancer

7. Temporal Trends of Transcatheter Edge-to-Edge Repair of the Mitral Valve Short-Term Outcomes in the United States: Nationwide Representative Study

8. Causes of Death After Neuroendocrine Tumors Diagnosis

9. Short-Term Outcomes of Transcatheter Aortic Valve Replacement in Kidney Transplant Recipients: A Nationwide Representative Study

10. Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): From Guidelines to Clinical Practice

11. Epidemiology of Cholangiocarcinoma; United States Incidence and Mortality Trends

12. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017

13. The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

14. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017

15. Temporal trends of pancreatic ductal adenocarcinoma in young adults in the United States: A Population-Based Study

16. Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017

17. The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017

18. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

19. The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

20. Risk and survival of chronic myeloid leukemia after breast cancer: A population-based study.

21. Impact of Hospital Procedural Volume on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve.

22. Initial systemic chemotherapeutic and targeted therapy strategies for the treatment of colorectal cancer patients with liver metastases

23. Trends in Clinical Characteristics and Outcomes in ST-Elevation Myocardial Infarction Hospitalizations in the United States, 2002-2016.

24. Short-Term Outcomes Following Urgent Transcatheter Edge-to-Edge Repair With MitraClip in Cardiogenic Shock: A Population-Based Analysis.

25. Conduction Disturbance, Pacemaker Rates, and Hospital Length of Stay Following Transcatheter Aortic Valve Implantation with the Sapien 3 Valve

26. Risk Stratification and Management of Advanced Conduction Disturbances Following TAVI in Patients With Pre-Existing RBBB

27. Abstract 11507: Radiation Reduction in Catheterization Laboratory: Single Center Experience

28. Abstract 11938: Mechanisms of Significant Functional Tricuspid Regurgitation in Pulmonary Arterial Hypertension

29. Causes of Death Among Patients With Metastatic Prostate Cancer in the US From 2000 to 2016

30. The risk of melanoma in patients with chronic lymphocytic leukemia; a population-based study.

31. Abstract P869: Racial Disparities in Pregnancy-Associated Stroke, a US Nationwide Cohort Study

32. Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

33. Abstract 13768: Impact of Socioeconomic Status on 30-Day Readmission Risk in Young Patients With First Acute Myocardial Infarction: A Population-Based Cohort Study

34. Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

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