1. Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
- Author
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Ruiz-de-León, María J., Jiménez-Sousa, María A., Moreno, Santiago, García, Marcial, Gutiérrez-Rivas, Mónica, León, Agathe, Montero-Alonso, Marta, González-García, Juan, Resino, Salvador, Rallón, Norma, Benito, José M., Vallejo, Alejandro, Benito, J.M., Rallón, N., Restrepo, C., Rodríguez, N., García, M., Cabello, A., Gorgolas, M., Resino, S., Briz, V., Jiménez, M.A., Vázquez, M.S., Fernández, A., García, P., Muñoz, M.A., Sánchez, J., Jiménez, J.L., Sepúlveda, D., García, I., Consuegra, I., León, A., Arnedo, M., Plana, M., Climent, N., García, F., Ruiz-Mateos, E., Domínguez, B., Tarancón, L., Rafii-El-Idrissi, M., Polaino, M.J., Genebat, M., Viciana, P., Leal, M., Vidal, F., Rodríguez, E., Viladés, C., Peraire, J., Romero, J., Rodríguez, C, Vera, M., Esté, J., Ballana, E., Martínez, M.A., Franco, S., Nevot, M., Vallejo, A., Moreno, S., Pernas, M., Casado, C., López, C., Capa, L., Pérez, M., Alcami, J., Sanjuán, R., Cueva, J.M., Delgado, R., Sierra, O., and Valenzuela, A.
- Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.
- Published
- 2019
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