Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Authors :: Ruiz-de-León, María J.
Jiménez-Sousa, María A.
Moreno, Santiago
García, Marcial
Gutiérrez-Rivas, Mónica
León, Agathe
Montero-Alonso, Marta
González-García, Juan
Resino, Salvador
Rallón, Norma
Benito, José M.
Vallejo, Alejandro
Benito, J.M.
Rallón, N.
Restrepo, C.
Rodríguez, N.
García, M.
Cabello, A.
Gorgolas, M.
Resino, S.
Briz, V.
Jiménez, M.A.
Vázquez, M.S.
Fernández, A.
García, P.
Muñoz, M.A.
Sánchez, J.
Jiménez, J.L.
Sepúlveda, D.
García, I.
Consuegra, I.
León, A.
Arnedo, M.
Plana, M.
Climent, N.
García, F.
Ruiz-Mateos, E.
Domínguez, B.
Tarancón, L.
Rafii-El-Idrissi, M.
Polaino, M.J.
Genebat, M.
Viciana, P.
Leal, M.
Vidal, F.
Rodríguez, E.
Viladés, C.
Peraire, J.
Romero, J.
Rodríguez, C
Vera, M.
Esté, J.
Ballana, E.
Martínez, M.A.
Franco, S.
Nevot, M.
Vallejo, A.
Moreno, S.
Pernas, M.
Casado, C.
López, C.
Capa, L.
Pérez, M.
Alcami, J.
Sanjuán, R.
Cueva, J.M.
Delgado, R.
Sierra, O.
Valenzuela, A.
Source :: Journal of Microbiology, Immunology and Infection; August 2019, Vol. 52 Issue: 4 p667-671, 5p
Publication Year :: 2019
Abstract: Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

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