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Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estudios de Filosofía is the property of Universidad de Antioquia, Instituto de Filosofia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The recent development of specialized research fields in philosophy of memory and philosophy of perception invites a dialogue about the relationship between these mental capacities. Following a brief review of some of the key issues that can be raised at the interface of memory and perception, this introduction provides an overview of the contributions to the special issue, and outlines possible directions for further research. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a neurodegenerative disorder related, in part, to the accumulation of amyloid-β peptide (Aβ) and especially the Aβ peptide 1-42 (Aβ 1-42 ). The aim of this study was to design nanocarriers able to: (i) interact with the Aβ 1-42 in the blood and promote its elimination through the “ sink effect ” and (ii) correct the memory defect observed in AD-like transgenic mice. To do so, biodegradable, PEGylated nanoparticles were surface-functionalized with an antibody directed against Aβ 1-42 . Treatment of AD-like transgenic mice with anti-Aβ 1-42 -functionalized nanoparticles led to: (i) complete correction of the memory defect; (ii) significant reduction of the Aβ soluble peptide and its oligomer level in the brain and (iii) significant increase of the Aβ levels in plasma. This study represents the first example of Aβ 1-42 monoclonal antibody-decorated nanoparticle-based therapy against AD leading to complete correction of the memory defect in an experimental model of AD. [ABSTRACT FROM AUTHOR]

Learning and memory are among the executive functions attributed to intelligent forms of life. Unfortunately, there is a lack of clear understanding regarding the underlying mechanisms governing these functions. Most of the modern day scientists attribute these functions solely to brain. However, in the latter half of last century, a number of reports suggested existence of extra-cranial memory and potential of its transfer between animals. Some have linked this phenomenon to RNA while others believed that peptides were responsible. The terms like "educated RNA" and "scotophobin" were coined. This atypical work involving flatworms, yeast RNA and scotophobin was received with deep skepticism and ultimately disregarded. However, the recent reproduction of some of this earlier work by scientists at Tufts University has reignited the debate on the mechanisms of learning and memory. Keeping this in view, we believe it is high time to summarize this historical work and discuss the possibilities to delineate these atypical claims. The objective is to incite the present day researchers to explore this opportunity under the perspective of newer advancements in science. [ABSTRACT FROM AUTHOR]

A semantic tagger aiming to detect relevant entities in Arabic medical documents and tagging them with their appropriate semantic class is presented. The system takes profit of a Multilingual Framework covering four languages (Arabic, English, French, and Spanish), in a way that resources available for each language can be used to improve the results of the others, this is specially important for less resourced languages as Arabic. The approach has been evaluated against Wikipedia pages of the four languages belonging to the medical domain. The core of the system is the definition of a base tagset consisting of the three most represented classes in SNOMED-CT taxonomy and the learning of a binary classifier for each semantic category in the tagset and each language, using a distant learning approach over three widely used knowledge resources, namely Wikipedia , Dbpedia , and SNOMED-CT . [ABSTRACT FROM AUTHOR]

Aim of the present study is to model the human mental lexicon, by focussing on storage and processing dynamics, as lexical organisation relies on the process of input recoding and adaptive strategies for long-term memory organisation. A fundamental issue in word processing is represented by the emergence of the morphological organisation level in the lexicon, based on paradigmatic relations between fully-stored word forms. Morphology induction can be defined as the task of perceiving and identifying morphological formatives within morphologically complex word forms, as a function of the dynamic interaction between lexical representations and distribution and degrees of regularity in lexical data. In the computational framework we propose here (TSOMs), based on Self-Organising Maps with Hebbian connections defined over a temporal layer, the identification/perception of surface morphological relations involves the alignment of recoded representations of morphologically-related input words. Facing a non-concatenative morphology such as the Arabic inflectional system prompts a reappraisal of morphology induction through adaptive organisation strategies, which affect both lexical representations and long-term storage. We will show how a strongly adaptive self-organisation during training is conducive to emergent relations between word forms, which are concurrently, redundantly and competitively stored in human mental lexicon, and to generalising knowledge of stored words to unknown forms. [ABSTRACT FROM AUTHOR]

Despite the predation costs, sleep is ubiquitous in the animal realm. Humans spend a third of their life sleeping, and the quality of sleep has been related to co-morbidity, Alzheimer disease, etc. Excessive wakefulness induces rapid changes in cognitive performances, and it is claimed that one could die of sleep deprivation as quickly as by absence of water. In this context, the fact that a few people are able to go without sleep for months, even years, without displaying any cognitive troubles requires explanations. Theories ascribing sleep to memory consolidation are unable to explain such observations. It is not the case of the theory of sleep as the hebbian reinforcement of the inhibitory synapses (ToS-HRIS). Hebbian learning (Long Term Depression - LTD) guarantees that an efficient inhibitory synapse will lose its efficiency just because it is efficient at avoiding the activation of the post-synaptic neuron. This erosion of the inhibition is replenished by hebbian learning (Long Term Potentiation - LTP) when pre and post-synaptic neurons are active together - which is exactly what happens with the travelling depolarization waves of the slow-wave sleep (SWS). The best documented cases of months-long insomnia are reports of patients with Morvan's syndrome. This syndrome has an autoimmune cause that impedes - among many things - the potassium channels of the post-synaptic neurons, increasing LTP and decreasing LTD. We hypothesize that the absence of inhibitory efficiency erosion during wakefulness (thanks to a decrease of inhibitory LTD) is the cause for an absence of slow-wave sleep (SWS), which results also in the absence of REM sleep. [ABSTRACT FROM AUTHOR]

The article presents a discussion on developments in research on the relations between music and human memory. The author takes note of a related 2007 study by musicologist Andreas Dorschel, also commenting on works by artistic and medical theorists throughout history, such as Jean-Jacques Rousseau, Theodor Zwinger, and George Gordon Byron. Discussion focuses on the metaphysical aspects of music associated with shepherds in Byron's poem "Manfred." Further attention is paid to motifs of transience connected to alphorn music in works by poet Jean Paul.

Summary: This review paper discusses the relationship between the mastication and learning and memory in rats. Immunohistochemistry of choline acetyltransferase (ChAT) showed that the numbers of ChAT-positive neurons in the nucleus of the diagonal band/medial septal nucleus (NDB/MS) of a powder diet group (PDG) and a molar crown-less powder diet group (MCPDG) were smaller than those of solid diet group (SDG). Subsequently, the concentrations of acetylcholine (ACh) in the hippocampus and in the cerebral cortex in MCPDG were significantly lower than that of SDG. The response latency of the MCPDG group was significantly shorter in passive avoidance tests. The impact of mastication on recovery of learning and memory function rats receiving permanent middle cerebral artery occlusion (MCAO) was also evaluated. In a Morris water maze task, rats fed a solid diet after MCAO surgery had greater functional recovery than rats fed a liquid. Finally, a whole-cell patch-clamp study revealed crucial roles of nitric oxide (NO) in the physiological control of cholinergic neurons in NDB/MS and in the pathogenic mechanism for cell death. Collectively, these results suggest key roles for NO both in the learning and memory function, and potentially in dementia. Mastication may have a significant impact on the maintenance and recovery of learning and memory, presumably through pathogenic and physiological mechanisms of NO action. [Copyright &y& Elsevier]

Summary: Most excitatory input in the hippocampus impinges on dendritic spines. Therefore, the dendritic spines are likely to be of major importance for neural processing. The morphology of dendritic spines is very diverse and changes in spine size as well as in their density are thought to reflect changes in the strength of synaptic transmission. Thus, alterations in dendritic spine densities or shape are suspected to be morphological manifestations of psychopathological, pathophysiological, physiological and/or behavioural changes. However, in spite of a long history of research, the specific function of dendritic spines within the hippocampal formation is still not well understood. This review will shed light on the hippocampal dendritic spines, their ultrastructure and morphology, as well as their supposed roles in neuronal plasticity and in certain mental illnesses. [Copyright &y& Elsevier]

The article presents a study which explores the distribution of KIBRA protein and protein kinase Mζ (PKMζ) in mouse neurons and in hippocampus. It also examines the specific antibodies against KIBRA, as well as the interaction between KIBRA and PKMζ. The data gathered from the mouse subjects were analyzed through immunoprecipitation and in situ hybridization. Findings reveal that KIBRA and PKMζ can possibly operate together in memory performance at the cellular level.