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366 results on '"Olson, J. A."'

1. Thermal vacuum testing of the compact cryocooler control electronics (C3E) with a Lockheed Martin microcryocooler

Author: Fulop, Gabor F., MacDougal, Michael H., Ting, David Z., Kimata, Masafumi, Kirkconnell, C. S., Baxter, J. M., Hon, R. C., Smith, C. K., Huynh, L., Gregoire, J. F., Kaszeta, R. W., Olson, J. R., and Roth, E.
Published: 2024
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2. Health Equity Implications of Missing Data Among Youths With Childhood‐OnsetSystemic Lupus Erythematosus: A Proof‐of‐ConceptStudy in the Childhood Arthritis and Rheumatology Research Alliance Registry

Author: Woo, Jennifer M. P., Simmonds, Faith, Dennos, Anne, Son, Mary Beth F., Lewandowski, Laura B., Rubinstein, Tamar B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Marafon, D. Pires, Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: Health disparities in childhood‐onset systemic lupus erythematosus (SLE) disproportionately impact marginalized populations. Socioeconomically patterned missing data can magnify existing health inequities by supporting inferences that may misrepresent populations of interest. Our objective was to assess missing data and subsequent health equity implications among participants with childhood‐onset SLE enrolled in a large pediatric rheumatology registry. We evaluated co‐missingness of 12 variables representing demographics, socioeconomic position, and clinical factors (e.g., disease‐related indices) using Childhood Arthritis and Rheumatology Research Alliance Registry childhood‐onset SLE enrollment data (2015–2022; n = 766). We performed logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for missing disease‐related indices at enrollment (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI‐2K] and/or Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) associated with data missingness. We used linear regression to assess the association between socioeconomic factors and SLEDAI‐2K at enrollment using 3 analytic methods for missing data: complete case analysis, multiple imputation, and nonprobabilistic bias analyses, with missing values imputed to represent extreme low or high disadvantage. On average, participants were missing 6.2% of data, with over 50% of participants missing at least 1 variable. Missing data correlated most closely with variables within data categories (i.e., demographic). Government‐assisted health insurance was associated with missing SLEDAI‐2K and/or SDI scores compared to private health insurance (OR 2.04 [95% CI 1.22, 3.41]). The different analytic approaches resulted in varying analytic sample sizes and fundamentally conflicting estimated associations. Our results support intentional evaluation of missing data to inform effect estimate interpretation and critical assessment of causal statements that might otherwise misrepresent health inequities.
Published: 2023
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3. Childhood‐OnsetLupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐TermKidney Status and Variation in Care

Author: Smitherman, Emily A., Chahine, Rouba A., Beukelman, Timothy, Lewandowski, Laura B., Rahman, A. K. M. Fazlur, Wenderfer, Scott E., Curtis, Jeffrey R., Hersh, Aimee O., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: The goal was to characterize short‐term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood‐onset systemic lupus erythematosus (cSLE) and nephritis. We analyzed previously collected prospective data from North American patients with cSLE with kidney biopsy‐proven nephritis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry from March 2017 through December 2019. We determined the proportion of patients with abnormal kidney status at the most recent registry visit and applied generalized linear mixed models to identify associated factors. We also calculated frequency of medication use, both during induction and ever recorded. We identified 222 patients with kidney biopsy–proven nephritis, with 64% class III/IV nephritis on initial biopsy. At the most recent registry visit at median (interquartile range) of 17 (8–29) months from initial kidney biopsy, 58 of 106 patients (55%) with available data had abnormal kidney status. This finding was associated with male sex (odds ratio [OR] 3.88, 95% confidence interval [95% CI] 1.21–12.46) and age at cSLE diagnosis (OR 1.23, 95% CI 1.01–1.49). Patients with class IV nephritis were more likely than class III to receive cyclophosphamide and rituximab during induction. There was substantial variation in mycophenolate, cyclophosphamide, and rituximab ever use patterns across rheumatology centers. In this cohort with predominately class III/IV nephritis, male sex and older age at cSLE diagnosis were associated with abnormal short‐term kidney status. We also observed substantial variation in contemporary medication use for pediatric lupus nephritis between pediatric rheumatology centers. Additional studies are needed to better understand the impact of this variation on long‐term kidney outcomes.
Published: 2023
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4. Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry

Author: Ringold, Sarah, Dennos, Anne C., Kimura, Yukiko, Beukelman, Timothy, Shrader, Peter, Phillips, Thomas A., Kohlheim, Melanie, Schanberg, Laura E., Yeung, Rae S. M., Horton, Daniel B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Magni Manzoni, S., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: Children with well‐controlled juvenile idiopathic arthritis (JIA) frequently experience flares after medication discontinuation, but the outcomes of these flares have not been well described. The objective of this study was to characterize the rates and predictors of disease recapture among children with JIA who restarted medication to treat disease flare. Children with JIA who discontinued conventional synthetic or biologic disease‐modifying antirheumatic drugs for well‐controlled disease but subsequently experienced a flare and restarted medication were identified from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. The primary outcome was inactive disease (ID) (physician global assessment <1 and active joint count = 0) 6 months after flare. A total of 333 patients had complete data for ID at 6 months after flare. The recapture rate for the cohort was 55%, ranging from 47% (persistent oligoarthritis) to 69% (systemic arthritis) (P= 0.4). Approximately 67% of children achieved ID by 12 months. In the multivariable model, history and reinitiation of biologic drugs were associated with increased odds of successful recapture (odds ratio [OR] 4.79 [95% confidence interval (95% CI) 1.22–18.78] and OR 2.74 [95% CI 1.62–4.63], respectively). Number of joints with limited range of motion was associated with decreased odds (OR 0.83 per 1 joint increase [95% CI 0.72–0.95]). Approximately half of JIA flares post‐discontinuation were recaptured within 6 months, but rates of recapture varied across JIA categories. These findings inform shared decision‐making for patients, families, and clinicians regarding the risks and benefits of medication discontinuation. Better understanding of biologic predictors of successful recapture in JIA are needed.
Published: 2023
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5. HDAC9structural variants disrupting TWIST1transcriptional regulation lead to craniofacial and limb malformations

Author: Hirsch, Naama, Dahan, Idit, D'haene, Eva, Avni, Matan, Vergult, Sarah, Vidal-García, Marta, Magini, Pamela, Graziano, Claudio, Severi, Giulia, Bonora, Elena, Nardone, Anna Maria, Brancati, Francesco, Fernández-Jaén, Alberto, Rory, Olson J., Hallgrímsson, Benedikt, and Birnbaum, Ramon Y.
Abstract: Structural variants (SVs) can affect protein-coding sequences as well as gene regulatory elements. However, SVs disrupting protein-coding sequences that also function as cis-regulatory elements remain largely uncharacterized. Here, we show that craniosynostosis patients with SVs containing the histone deacetylase 9 (HDAC9) protein-coding sequence are associated with disruption of TWIST1regulatory elements that reside within the HDAC9sequence. Based on SVs within the HDAC9‐TWIST1locus, we defined the 3′-HDAC9sequence as a critical TWIST1regulatory region, encompassing craniofacial TWIST1enhancers and CTCF sites. Deletions of either Twist1enhancers (eTw5-7Δ/Δ) or CTCF site (CTCF-5Δ/Δ) within the Hdac9protein-coding sequence led to decreased Twist1expression and altered anterior/posterior limb expression patterns of SHH pathway genes. This decreased Twist1expression results in a smaller sized and asymmetric skull and polydactyly that resembles Twist1+/−mouse phenotype. Chromatin conformation analysis revealed that the Twist1promoter interacts with Hdac9sequences that encompass Twist1enhancers and a CTCF site, and that interactions depended on the presence of both regulatory regions. Finally, a large inversion of the entire Hdac9sequence (Hdac9INV/+) in mice that does not disrupt Hdac9expression but repositions Twist1regulatory elements showed decreased Twist1expression and led to a craniosynostosis-like phenotype and polydactyly. Thus, our study elucidates essential components of TWIST1transcriptional machinery that reside within the HDAC9sequence. It suggests that SVs encompassing protein-coding sequences could lead to a phenotype that is not attributed to its protein function but rather to a disruption of the transcriptional regulation of a nearby gene.
Published: 2022
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6. Down Syndrome–Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes

Author: Jones, Jordan T., Smith, Chelsey, Becker, Mara L., Lovell, Daniel, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Akoghlanian, S., Al Ahmed, O., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Anastasopoulos, D., Anderson, E., Andrew, M., Ardalan, K., Ardoin, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Birmingham, J., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Brooks, E., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullington, A., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carpenter, S., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chiu, Y., Chundru, K., Clairman, H., Co, D., Collins, K., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Cospito, T., Costanzo, D., Cron, R., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Dionizovik‐Dimanovski, M., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Drummond, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edens, C., Edens, C., Edgerly, Y., Elder, M., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Feldman, B., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleck, D., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gergely, T., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Goh, I., Goldberg, T., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Guevara, M., Guittar, P., Gurion, R., Guzman, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hansman, E., Hanson, A., Harel, L., Haro, S., Harris, J., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hughes, R., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Iqbal, S., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Kahn, P., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khaleel, M., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lang, B., Lapidus, S., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Luca, N., Lvovich, S., Ma, M., Mackey, C., Madison, C., Madison, J., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCallum, B., McCarthy, K., McConnell, K., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McHugh, A., McKibben, K., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Morris, S., Moss, C., Moussa, T., Mruk, V., Mulvhihill, E., Muscal, E., Nahal, B., Nanda, K., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nguyen, E., Nicholas, J., Nigrovic, P., Nocton, J., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., O’Connor, M., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orlando, M., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Punaro, M., Puplava, B., Quach, J., Quinlan‐Waters, M., Quintero, A., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramsay, E., Ramsey, S., Reed, A., Reed, A., Reed, A., Reid, H., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Roberson, S., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosenwasser Raines, N., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster–Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabatino, M., Sabbagh, S., Sadun, R., Sandborg, C., Sanni, A., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shen, B., Shenoi, S., Shergill, K., Shiff, N., Shirley, J., Shishov, M., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Snider, C., Soep, J., Son, M., Soybilgic, A., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Stasek, J., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stoops, S., Strelow, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sura, A., Sutter, M., Syed, R., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Treemarcki, E., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vega‐Fernandes, P., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Wang, C., Waqar, L., Waterfield, M., Watson, M., Watts, A., Waugaman, B., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zemel, L., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: Down syndrome–associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize clinical manifestations and therapeutic preferences in DA compared to JIA, using the new Childhood Arthritis and Rheumatology Research Alliance (nCARRA) registry. In a case–control study, between July 2015 and March 2019, patients with a diagnosis of JIA and Down syndrome (DS) were identified and matched by age, sex, and JIA subtype to patients who have JIA without DS. Collected data included demographic characteristics, disease characteristics, laboratory results, treatment exposure, and outcome measures. A total of 36 children with DA and 165 with JIA were identified. Most patients presented with polyarticular rheumatoid factor–negative disease. At entry into the nCARRA registry, there were minimal differences between the groups, and at the last visit there were significant differences (P< 0.05) for multiple outcome measures. Patients with DA and those with JIA had similar therapeutic exposure to disease‐modifying antirheumatic drugs (DMARDs) and biologics, but those with DA had more DMARD‐related adverse events (93% versus 25%) and biologic therapy ineffectiveness (60% versus 17%). There was little difference between patients with DA and those with JIA at baseline, and similar therapy was implemented for those in the nCARRA registry; however, at the last visit, the patients with DA had greater disease burden. Additionally, there were more DMARD‐related adverse events and biologic ineffectiveness for those patients with DA. More research is needed to determine differences in pathophysiology and optimal therapeutic approaches.
Published: 2021
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7. The Line Emission Mapper (LEM) probe mission concept

Author: den Herder, Jan-Willem A., Nikzad, Shouleh, Nakazawa, Kazuhiro, Kraft, R., Bogdán, Á., ZuHone, J., Adams, J. S., Alvarado-Gómez, J. D., Argiroffi, C., Ayromlou, M., Azadi, M., Bandler, S. R., Barbera, M., Bhardwaj, A., Biffi, V., Bodewits, D., Boettcher, E., Branham, B., Burchett, J. N., Burke, D. J., Cann, J., Carter, J. A., Castro, D., Chakraborty, P., Chan, K. W., Chen, S., Churazov, E., Coderre, K., Corcoran, M. F., Cumbee, R. S., DePalo, S. V., Dolag, K., Donahue, M., Doriese, W. B., Drake, J. J., Dunn, W., Eckart, M. E., Eckert, D., Ettori, S., Ezoe, Y., Feldman, C. H., Flaccomio, E., Forman, W. R., Galeazzi, M., Gall, A. C., Garraffo, C., Gonzalez, M., Grosso, N., Hartley, J., Hell, N., Hernquist, L., Hodges-Kluck, E., Houston, J., Hull, S. V., Islam, N., Janas, P. M., Jennings, F. J., Jones, C., Kaaret, P., Kanner, H., Karovska, M., Kashyap, V., Kavanagh, P. J., Kelley, R. L., Khabibullin, I., Kilbourne, C. A., Kim, C.-G., Koutroumpa, D., Kovács, O. E., Kuntz, K. D., Lee, S.-H., Leutenegger, M. A., Linn, T., Lotti, S., Markevitch, M., Martin, K., May, L., McCammon, D., McEntee, S. C., Mei, S., Mernier, F., Miceli, M., Miller, J. B., Mirakhor, M. S., Monsch, K., Nazé, Y., Nelson, D., Nordt, A. A., Ogorzalek, A., Olson, J., Orlando, S., Osborne, E., Oskinova, L. M., Patnaude, D., Pfeifle, R. W., Pinto, C., Plucinsky, P., Ponti, G., Porquet, D., Porter, F. S., Préle, D., Ramm, S., Randall, S. W., Rasia, E., Rau, M. M., Richardson, S., Sakai, K. S., Sarkar, A., Schellenberger, G., Sciortino, S., Schaye, J., Simionescu, A., Smith, S. J., Sobolewska, M., Steiner, J. F., Stern, J., Su, Y., Sun, M., Truong, N., Ursino, E., Valentini, M., Veilleux, S., Vladutescu-Zopp, S., Vogelsberger, M., Wakeham, N. A., Walker, S. A., Wang, Q. D., Wargelin, B., Weaver, K. A., Werk, J. K., Werner, N., Wolk, S. J., Zhang, C., Zhang, W. W., and Zhuravleva, I.
Published: 2024
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8. Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA–B27, and Equal Sex Representation in Sacroiliitis

Author: Rumsey, Dax G., Lougee, Aimee, Matsouaka, Roland, Collier, David H., Schanberg, Laura E., Schenfeld, Jennifer, Shiff, Natalie J., Stoll, Matthew L., Stryker, Scott, Weiss, Pamela F., Beukelman, Timothy, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Magni Manzoni, S., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., Okeke, O., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Pires Marafon, D., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.
Abstract: To describe characteristics of children with enthesitis‐related arthritis (ERA) and juvenile psoriatic arthritis (PsA) who were enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. All children with ERA and those with juvenile PsA were identified. Demographic characteristics, clinical characteristics, and treatments were described. The children with sacroiliitis and those without sacroiliitis were compared. In the children with sacroiliitis, the first visit with clinically active sacroiliitis (which came first in 72% of cases) was compared to the first visit without clinically active sacroiliitis. A total of 902 children with ERA or juvenile PsA were identified. Children with ERA were older at diagnosis (ages 10.8 years versus 8.2 years; P< 0.01) and were more likely to be male (56% versus 38%; P< 0.01). Polyarticular involvement was reported in 57% of children with ERA and in 72% of those with juvenile PsA. Of the children tested, HLA–B27 was positive in 38% of those in the ERA group and in 12% of those in the juvenile PsA group. At least 1 biologic was taken by 72% of those with ERA and 64% of those with juvenile PsA. Sacroiliitis (diagnosed clinically and/or by imaging) was reported in 28% of the children (40% of those with ERA and 12% of those with juvenile PsA). Of these, 54% of the children were female, 36% were HLA–B27 positive, and 81% took at least 1 biologic. In children with sacroiliitis, scores according to the physician global assessment of disease activity, parent/patient global assessment of well‐being, and clinical Juvenile Arthritis Disease Activity Score 10 were all significantly worse at the first visit with clinically active sacroiliitis versus the first visit without active sacroiliitis. In this registry, there are more than 900 children with ERA or juvenile PsA. There was high biologic use in this population, especially in those with sacroiliitis. Further, there was equal sex representation in those children with sacroiliitis.
Published: 2021
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9. On the development of a continuous methodology to fractionate microfibriallated cellulose

Author: Shanb Ghazani, M., Martinez, D. M., Al-Shibl, M., Madani, A., Olson, J., DeMuner, B., and Kadla, J.
Abstract: The focus of this study is the development of a methodology to mechanically separate or fractionate micro-fibrillated fibre suspensions (MFC) into different size classes. We extend the principle outlined by Madani et al.(2010) and create a continuous separation in an annular gap undergoing spiral Poiseuille flow (solid body rotation superimposed on pressure driven flow). Achieving hydrodynamic stability of this flow was the main scientific challenge for scale-up. This work is presented in two different studies. In the first study, we perform a series of batch-wise centrifugation tests to develop the criteria for motion of the individual classes of particles which compose a Eucalyptus MFC suspension. Here, we suspend the MFC in a weak gel and demonstrate a linear reduction in average particle size with increasing centrifugal force; motion is initiated in heavier particles before the lighter ones. In the second study, we use this batch-wise data to design a continuous prototype and we successfully demonstrate a continuous separation with performance similar to that achieved in the batch-wise tests.
Published: 2020
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10. Association of Short‐Term Ultraviolet Radiation Exposure and Disease Severity in Juvenile Dermatomyositis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

Author: Neely, Jessica, Long, Craig S., Sturrock, Hugh, Kim, Susan, Abramson, L., Anderson, E., Andrew, M., Battle, N., Becker, M., Benham, H., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Brunner, H., Cabrera, A., Canter, D., Carlton, D., Caruso, B., Ceracchio, L., Chalom, E., Chang, J., Charpentier, P., Clark, K., Dean, J., Dedeoglu, F., Feldman, B., Ferguson, P., Fox, M., Francis, K., Gervasini, M., Goldsmith, D., Gorton, G., Gottlieb, B., Graham, T., Griffin, T., Grosbein, H., Guppy, S., Haftel, H., Helfrich, D., Higgins, G., Hillard, A., Hollister, J. R., Hsu, J., Hudgins, A., Hung, C., Huttenlocher, A., Ilowite, N., Imlay, A., Imundo, L., Inman, C. J., Jaqith, J., Jerath, R., Jung, L., Kahn, P., Kapedani, A., Kingsbury, D., Klein, K., Klein‐Gitelman, M., Kunkel, A., Lapidus, S., Layburn, S., Lehman, T., Lindsley, C., MacgregorHannah, M., Malloy, M., Mawhorter, C., McCurdy, D., Mims, K., Moorthy, N., Morus, D., Muscal, E., Natter, M., Olson, J., O'Neil, K., Onel, K., Orlando, M., Palmquist, J., Phillips, M., Ponder, L., Prahalad, S., Punaro, M., Puplava, D., Quinn, S., Quintero, A., Rabinovich, C., Reed, A., Reed, C., Ringold, S., Riordan, M., Roberson, S., Robinson, A., Rossette, J., Rothman, D., Russo, D., Ruth, N., Schikler, K., Sestak, A., Shaham, B., Sherman, Y., Simmons, M., Singer, N., Spalding, S., Stapp, H., Syed, R., Thomas, E., Torok, K., Trejo, D., Tress, J., Upton, W., Vehe, R., Scheven, E., Walters, L., Weiss, J., Weiss, P., Welnick, N., White, A., Woo, J., Wootton, J., Yalcindag, A., Zapp, C., Zemel, L., and Zhu, A.
Abstract: Ultraviolet (UV) radiation is considered to be an important environmental factor in the clinical course of children with juvenile dermatomyositis (DM). We aimed to evaluate the association between UV radiation and severe disease outcomes in juvenile DM. This is a cross‐sectional study of patients with juvenile DM enrolled in the US multicenter Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry from 2010 to 2015. The mean UV index (UVI) in the calendar month prior to symptom onset in each subject's zip code was calculated from daily satellite solar noon measurements. Multivariable logistic regression was used to model the relationship between the mean UVI and calcinosis as well as other outcomes of severe disease. Covariates included sex, race, age, time to diagnosis, disease duration, and latitude. In a multivariable model, there was no association between the mean UVI and calcinosis. African American race was associated with a 3‐fold greater odds of calcinosis. However, there was a significant statistical interaction between race and mean UVI. Accounting for this interaction, the odds of calcinosis markedly decreased in African American subjects and steadily increased in non–African American subjects over a range of increasing the mean UVI. Higher mean UVI was associated with decreased odds of using biologics or nonmethotrexate disease‐modifying antirheumatic drugs and skin ulceration. We described a novel association between UV radiation, calcinosis, and race in a large cohort of patients with juvenile DM. This study furthers our knowledge of the role of UV radiation in the clinical course of juvenile DM and highlights the complex interplay between genes and environment in the clinical phenotypes and development of calcinosis in children with juvenile DM.
Published: 2019
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11. The Origins Space Telescope

Author: Barto, Allison A., Breckinridge, James B., Stahl, H. Philip, Leisawitz, D., Amatucci, E., Allen, L., Arenberg, J., Armus, L., Battersby, C., Beaman, B. G., Bauer, J., Bell, R., Beltran, P., Benford, D., Bergin, E., Bolognese, J., Bradford, C. M., Bradley, D., Burgarella, D., Carey, S., Carter, R., Chi, J. D., Cooray, A., Corsetti, J., D'Asto, T., De Beck, E., Denis, K., Derkacz, C., Dewell, L., DiPirro, M., Earle, C. P., East, M., Edgington, S., Ennico, K., Fantano, L., Feller, G., Flores, A., Folta, D., Fortney, J., Gavares, B. J., Generie, J., Gerin, M., Granger, Z., Greene, T. P., Griffiths, A., Harpole, G., Harvey, K., Helmich, F., Helou, G., Hilliard, L., Howard, J., Jacoby, M., Jamil, A., Jamison, T., Kaltenegger, L., Kataria, T., Knight, J. S., Knollenberg, P., Lawrence, C., Lightsey, P., Lipscy, S., Lynch, C., Mamajek, E., Martins, G., Mather, J. C., Meixner, M., Melnick, G., Milam, S., Mooney, T., Moseley, S. H., Narayanan, D., Neff, S., Nguyen, T., Nordt, A., Olson, J., Padgett, D., Petach, M., Petro, S., Pohner, J., Pontoppidan, K., Pope, A., Ramspacher, D., Rao, A., Rieke, G., Rieke, M., Roellig, T., Sakon, I., Sandin, C., Sandstrom, K., Scott, D., Seals, L., Sheth, K., Staguhn, J., Steeves, J., Stevenson, K., Stokowski, L., Stoneking, E., Su, K., Tajdaran, K., Tompkins, S., Turner, J., Vieira, J., Webster, C., Wiedner, M., Wright, E. L., Wu, C., and Zmuidzinas, J.
Published: 2019
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12. The Role of Chemistry in Fracture Pattern Development and Opportunities to Advance Interpretations of Geological Materials

Author: Laubach, S. E., Lander, R. H., Criscenti, L. J., Anovitz, L. M., Urai, J. L., Pollyea, R. M., Hooker, J. N., Narr, W., Evans, M. A., Kerisit, S. N., Olson, J. E., Dewers, T., Fisher, D., Bodnar, R., Evans, B., Dove, P., Bonnell, L. M., Marder, M. P., and Pyrak‐Nolte, L.
Abstract: Fracture pattern development has been a challenging area of research in the Earth sciences for more than 100 years. Much has been learned about the spatial and temporal complexity inherent to these systems, but severe challenges remain. Future advances will require new approaches. Chemical processes play a larger role in opening‐mode fracture pattern development than has hitherto been appreciated. This review examines relationships between mechanical and geochemical processes that influence the fracture patterns recorded in natural settings. For fractures formed in diagenetic settings (~50 to 200 °C), we review evidence of chemical reactions in fractures and show how a chemical perspective helps solve problems in fracture analysis. We also outline impediments to subsurface pattern measurement and interpretation, assess implications of discoveries in fracture history reconstruction for process‐based models, review models of fracture cementation and chemically assisted fracture growth, and discuss promising paths for future work. To accurately predict the mechanical and fluid flow properties of fracture systems, a processes‐based approach is needed. Progress is possible using observational, experimental, and modeling approaches that view fracture patterns and properties as the result of coupled mechanical and chemical processes. A critical area is reconstructing patterns through time. Such data sets are essential for developing and testing predictive models. Other topics that need work include models of crystal growth and dissolution rates under geological conditions, cement mechanical effects, and subcritical crack propagation. Advances in machine learning and 3‐D imaging present opportunities for a mechanistic understanding of fracture formation and development, enabling prediction of spatial and temporal complexity over geologic timescales. Geophysical research with a chemical perspective is needed to correctly identify and interpret fractures from geophysical measurements during site characterization and monitoring of subsurface engineering activities. Fracture patterns in rock strongly affect directions, magnitudes, and heterogeneities of both fluid flow and rock strength. Accurate and testable predictions of patterns are essential for understanding many societally important processes in the Earth and for effectively managing subsurface engineering operations. Chemical processes play a larger role in opening‐mode fracture pattern development than has hitherto been appreciated. For fractures formed at depths of ~1–10 km and temperatures of 50–200 °C, new evidence shows chemical reactions are common and more diverse than previously recognized. We describe how viewing fracture formation and evolution from a chemical perspective helps to solve problems in fracture pattern analysis. We outline the main impediments to subsurface fracture pattern measurement and interpretation, assess implications of recent discoveries in fracture history reconstruction for process‐based models of fracture and cement accumulation, review models of fracture cementation and chemically assisted fracture growth, and discuss promising paths for future work. Potential exists for basic scientific investigations to lead to progress on what has been one of the most refractory practical problems in subsurface science. Results suggest that progress in fracture interpretation and prediction can be made using observational, experimental, modeling, and theoretical approaches that view fracture patterns as the result of coupled mechanical and chemical processes. A chemical perspective helps solve challenges to understanding subsurface fractures: inadequate samples, ambiguous analogs, and difficulties determining which models are correct from observationsMany tools of chemical analysis, experiment, modeling, and theory have yet to be brought to bear on understanding how fracture patterns develop at geological timescalesChemical and mechanical investigations together have great potential to solve challenging practical problems in subsurface science
Published: 2019
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13. Recent Canadian efforts to develop population-level pregnancy intervention studies to mitigate effects of natural disasters and other tragedies

Author: Olson, D. M., Brémault-Phillips, S., King, S., Metz, G. A.S., Montesanti, S., Olson, J. K., Hyde, A., Pike, A., Hoover, T., Linder, R., Joggerst, B., and Watts, R.
Abstract: AbstractThe preconception, pregnancy and immediate postpartum and newborn periods are times for mothers and their offspring when they are especially vulnerable to major stressors – those that are sudden and unexpected and those that are chronic. Their adverse effects can transcend generations. Stressors can include natural disasters or political stressors such as conflict and/or migration. Considerable evidence has accumulated demonstrating the adverse effects of natural disasters on pregnancy outcomes and developmental trajectories. However, beyond tracking outcomes, the time has arrived for gathering more information related to identifying mechanisms, predicting risk and developing stress-reducing and resilience-building interventions to improve outcomes. Further, we need to learn how to encapsulate both the quantitative and qualitative information available and share it with communities and authorities to mitigate the adverse developmental effects of future disasters, conflicts and migrations. This article briefly reviews prenatal maternal stress and identifies three contemporary situations (wildfire in Fort McMurray, Alberta, Canada; hurricane Harvey in Houston, USA and transgenerational and migrant stress in Pforzheim, Germany) where current studies are being established by Canadian investigators to test an intervention. The experiences from these efforts are related along with attempts to involve communities in the studies and share the new knowledge to plan for future disasters or tragedies.
Published: 2019
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14. Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

Author: Stevens, Brandi E., Torok, Kathryn S., Li, Suzanne C., Hershey, Nicole, Curran, Megan, Higgins, Gloria C., Moore, Katharine F., Egla Rabinovich, C., Dodson, Samuel, Stevens, Anne M., Abramson, L, Anderson, E., Andrew, M., Battle, N., Becker, M., Benham, H., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Brunner, H., Cabrera, A., Canter, D., Carlton, D., Caruso, B., Ceracchio, L., Chalom, E., Chang, J., Charpentier, P., Clark, K., Dean, J., Dedeoglu, F., Feldman, B., Ferguson, P., Fox, M., Francis, K., Gervasini, M., Goldsmith, D., Gorton, G., Gottlieb, B., Graham, T., Griffin, T., Grosbein, H., Guppy, S., Haftel, H., Helfrich, D., Hillard, A., Hollister, J. R., Hsu, J., Hudgins, A., Hung, C., Huttenlocher, A., Ilowite, N., Imlay, A., Imundo, L., Inman, C. J., Jaqith, J., Jerath, R., Jung, L., Kahn, P., Kapedani, A., Kingsbury, D., Klein, K., Klein‐Gitelman, M., Kunkel, A., Lapidus, S., Layburn, S., Lehman, T., Lindsley, C., Macgregor‐Hannah, M., Malloy, M., Mawhorter, C., McCurdy, D., Mims, K., Moorthy, N., Morus, D., Muscal, E., Natter, M., Olson, J., O'Neil, K., Onel, K., Orlando, M., Palmquist, J., Phillips, M., Ponder, L., Prahalad, S., Punaro, M., Puplava, D., Quinn, S., Quintero, A., Reed, A., Reed, C., Ringold, S., Riordan, M., Roberson, S., Robinson, A., Rossette, J., Rothman, D., Russo, D., Ruth, N., Schikler, K., Sestak, A., Shaham, B., Sherman, Y., Simmons, M., Singer, N., Spalding, S., Stapp, H., Syed, R., Thomas, E., Torok, K., Trejo, D., Tress, J., Upton, W., Vehe, R., Scheven, E., Walters, L., Weiss, J., Weiss, P., Welnick, N., White, A., Woo, J., Wootton, J., Yalcindag, A., Zapp, C., Zemel, L., and Zhu, A.
Abstract: To investigate clinical manifestations of juvenile systemic sclerosis (SSc; scleroderma), including disease characteristics and patient quality of life, using the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry. Patients with juvenile SSc were prospectively enrolled between 2010 and 2013. The diagnosis of juvenile SSc was determined by the enrolling pediatric rheumatologist, with the requirement for disease onset prior to age 18 years. Collected data included demographics, disease characteristics, medication exposure, and quality of life metrics. In total, 64 patients with juvenile SSc were enrolled a median of 3.6 years after disease onset, which occurred at a median age of 10.3 years. The most common organ manifestations were dermatologic and vascular, followed by musculoskeletal, gastrointestinal, and pulmonary; in 38% of patients, ≥4 organ systems were affected. Patients with juvenile SSc had significantly more disability at enrollment compared with CARRALegacy Registry patients with juvenile idiopathic arthritis, dermatomyositis, or systemic lupus erythematosus. Although physician‐reported measures correlated most closely with arthritis, dermatologic manifestations, and pulmonary manifestations, poor patient‐reported measures were associated with gastrointestinal involvement. During >50 person‐years of follow‐up, most organ manifestations remained stable, and no mortality or development of new solid organ involvement after enrollment was reported. In the first multicenter prospective cohort of patients with juvenile SSc in North America, the disease burden was high: multiorgan manifestations were common, and functional disability was greater than that observed in patients with other childhood‐onset rheumatic diseases. Gastrointestinal involvement had the greatest impact on quality of life.
Published: 2018
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15. Bar force measurement in low consistency refining: the effect of plate pattern

Author: Harirforoush, R., Olson, J., and Wild, P.
Abstract: The effect of plate pattern on forces applied to pulp fibers by refiner bars in low consistency refining is investigated in an AIKAWA 16-inch single-disc refiner. These forces are measured using a custom-built piezoelectric sensor. Trials are conducted using SPF softwood thermomechanical pulp, northern bleached softwood kraft pulp, and aspen hardwood thermomechanical pulp at 3.3 to 3.6 % consistency at rotational speeds of 1200 and 1400 rpm. The pulp is sampled at regular intervals, and the length-weighted fiber length, freeness, tear index, and tensile index are measured for each sample. The results show that the plate with higher bar edge length results in lower mean peak normal and shear forces. The mean peak normal and shear forces at the onset of fiber cutting depend on rotational speed, pulp furnish and plate pattern, and these parameters are lower for a plate pattern with higher bar edge length. In addition, the mean coefficient of friction is a function of plate gap, pulp furnish, and plate pattern. The plate having higher bar edge length results in higher mean coefficient of friction.
Published: 2018
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16. Indications of the onset of fiber cutting in low consistency refining using a refiner force sensor: The effect of pulp furnish

Author: Harirforoush, R., Olson, J., and Wild, P.
Abstract: Detection of the onset of fiber cutting is beneficial in low consistency refining as it may prevent reduction of average fiber length, optimize fiber quality improvements by operating at gaps just wider than the critical gap, avoid decreasing the strength properties of paper, and increase energy efficiency. The objective of this study is to understand the effect of pulp furnish on measured bar forces and, more specifically, on the detection of fiber cutting. Bar forces, i. e. forces applied to pulp fibers by the refiner bars, are measured with a custom-designed piezoelectric force sensor. Trials were conducted with an AIKAWA 16-in. single-disc refiner using hemlock/balsam softwood thermomechanical pulp, SPF softwood thermomechanical pulp, northern bleached softwood kraft pulp, and aspen hardwood thermomechanical pulp at 3.0 to 3.5 % consistency at rotational speeds of 1200 and 1400 rpm. The power of the time domain signal of the measured forces is introduced as an indicator of the onset of fiber cutting. Our results show that this new fiber cutting metric is a sensitive and reliable metric for determination of fibre cutting for a range of pulp furnishes. The study suggests that the refiner force sensor has potential to be exploited for in-process detection of fiber cutting.
Published: 2018
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17. Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

Author: Rubinstein, Tamar B., Mowrey, Wenzhu B., Ilowite, Norman T., Wahezi, Dawn M., Abramson, L., Anderson, E., Andrew, M., Battle, N., Becker, M., Benham, H., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Brunner, H., Cabrera, A., Canter, D., Carlton, D., Caruso, B., Ceracchio, L., Chalom, E., Chang, J., Charpentier, P., Clark, K., Dean, J., Dedeoglu, F., Feldman, B., Ferguson, P., Fox, M., Francis, K., Gervasini, M., Goldsmith, D., Gorton, G., Gottlieb, B., Graham, T., Griffin, T., Grosbein, H., Guppy, S., Haftel, H., Helfrich, D., Higgins, G., Hillard, A., Hollister, J.R., Hsu, J., Hudgins, A., Hung, C., Huttenlocher, A., Imlay, A., Imundo, L., Inman, C.J., Jaqith, J., Jerath, R., Jung, L., Kahn, P., Kapedani, A., Kingsbury, D., Klein, K., Klein‐Gitelman, M., Kunkel, A., Lapidus, S., Layburn, S., Lehman, T., Lindsley, C., Macgregor‐Hannah, M., Malloy, M., Mawhorter, C., McCurdy, D., Mims, K., Moorthy, N., Morus, D., Muscal, E., Natter, M., Olson, J., O'Neil, K., Onel, K., Orlando, M., Palmquist, J., Phillips, M., Ponder, L., Prahalad, S., Punaro, M., Puplava, D., Quinn, S., Quintero, A., Rabinovich, C., Reed, A., Reed, C., Ringold, S., Riordan, M., Roberson, S., Robinson, A., Rossette, J., Rothman, D., Russo, D., Ruth, N., Schikler, K., Sestak, A., Shaham, B., Sherman, Y., Simmons, M., Singer, N., Spalding, S., Stapp, H., Syed, R., Thomas, E., Torok, K., Trejo, D., Tress, J., Upton, W., Vehe, R., Scheven, E., Walters, L., Weiss, J., Weiss, P., Welnick, N., White, A., Woo, J., Wootton, J., Yalcindag, A., Zapp, C., Zemel, L., and Zhu, A.
Abstract: Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographic and clinical characteristics of lupus patients within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry with regard to time between symptom onset and presentation to a pediatric rheumatologist. We analyzed data from 598 CARRALegacy Registry participants for differences between those who presented early (within <1 month of symptom onset), between 1–3 months (typical presentation), with moderate delays (3–12 months), and with severe delays (≥1 year). Factors associated with early presentation, moderate delay, and severe delay were determined by multinomial logistic regression. Forty‐four percent of patients presented early, while 23% had moderate delays and 9% had severe delays. Family history of lupus, absence of discoid rash, and location in a state with a higher density of pediatric rheumatologists were associated with earlier presentation. Younger age, low household income (<$25,000 per year), and a family history of lupus were associated with severe delay. Delays to care ≥1 year exist in a notable minority of pediatric lupus patients from the CARRALegacy Registry. In this large and diverse sample of patients, access to care and family resources played an important role in predicting time to presentation to a pediatric rheumatologist.
Published: 2018
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18. Comparisons of Heart Rate and Energy Expenditure During Exergaming in College-age Adults

Author: Oh, Y., Johnson, L. E., Olson, J. R., Shea, K. R., and Braun, S.
Abstract: The purpose of this study was twofold: 1) to discover the differences in degree of energy expenditure (EE) during Just Dance 2015 using Xbox 360 Kinect, Wii-U, PS3 Move, and Control YouTube video; and 2) to uncover whether or not exergaming could elicit moderate to vigorous levels of intensity (≥ 40% Heart Rate Reserve (HRR)) based on heart rate average (HRavg) measurements. Twenty-five healthy college-aged students participated in this study. Data collection was comprised of baseline testing, a 30 second familiarization period with each gaming console, and a gaming session. Participants danced to the song “Love Me Again” on a Just Dance 2015 program on Xbox 360 Kinect, Wii-U, PS3 Move, and a control YouTube. EE and HRR were calculated using FT4 Polar Heart Rate Monitor. One-way repeated measures ANOVA indicated no significant differences in energy expenditure across the consoles, F(2.74, 65.86)=0.65, p=.570. The paired samples t-test indicated the HRavgfor the Xbox 360 Kinect (117±18 bpm) was significantly greater than the HRavgfor the Control (112±16 bpm), t(24)=3.03, p=.006. About a third (28%-36%) of participants met moderate levels of intensity while exergaming. Dancing on all three major gaming consoles and YouTube video increase energy expenditures and can be used as an alternative form of exercise with the ability to achieve moderate levels of intensity.
Published: 2017
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19. The Natural History of Severe Acute Liver Injury

Author: Koch, David G, Speiser, J L, Durkalski, V, Fontana, R J, Davern, T, McGuire, B, Stravitz, R T, Larson, A M, Liou, I, Fix, O, Schilsky, M L, McCashland, T, Hay, J E, Murray, N, Shaikh, O S, Ganger, D, Zaman, A, Han, S B, Chung, R T, Brown, R S, Munoz, S, Reddy, K R, Rossaro, L, Satyanarayana, R, Hanje, A J, Olson, J, Subramanian, R M, Karvellas, C, Hameed, B, Sherker, A H, Lee, W M, and Reuben, A
Abstract: Objectives:Acute liver failure (ALF) is classically defined by coagulopathy and hepatic encephalopathy (HE); however, acute liver injury (ALI), i.e., severe acute hepatocyte necrosis without HE, has not been carefully defined nor studied. Our aim is to describe the clinical course of specifically defined ALI, including the risk and clinical predictors of poor outcomes, namely progression to ALF, the need for liver transplantation (LT) and death.Methods:386 subjects prospectively enrolled in the Acute Liver Failure Study Group registry between 1 September 2008 through 25 October 2013, met criteria for ALI: International Normalized Ratio (INR)≥2.0 and alanine aminotransferase (ALT)≥10 × elevated (irrespective of bilirubin level) for acetaminophen (N-acetyl-p-aminophenol, APAP) ALI, or INR≥2.0, ALT≥10x elevated, and bilirubin≥3.0 mg/dl for non-APAP ALI, both groups without any discernible HE. Subjects who progressed to poor outcomes (ALF, death, LT) were compared, by univariate analysis, with those who recovered. A model to predict poor outcome was developed using the random forest (RF) procedure.Results:Progression to a poor outcome occurred in 90/386 (23%), primarily in non-APAP (71/179, 40%) vs. only 14/194 (7.2%) in APAP patients comprising 52% of all cases (13 cases did not have an etiology assigned; 5 of whom had a poor outcome). Of 82 variables entered into the RF procedure: etiology, bilirubin, INR, APAP level and duration of jaundice were the most predictive of progression to ALF, LT, or death.Conclusions:A majority of ALI cases are due to APAP, 93% of whom will improve rapidly and fully recover, while non-APAP patients have a far greater risk of poor outcome and should be targeted for early referral to a liver transplant center.
Published: 2017
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20. The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3

Author: Li, Z, Bridges, B, Olson, J, and Weinman, S A
Abstract: The multispecific transcription factor and tumor suppressor FOXO3 is an important mediator of apoptosis, but the mechanisms that control its proapoptotic function are poorly understood. There has long been evidence that acetylation promotes FOXO3-driven apoptosis and recently a specific JNK (c-Jun N-terminal kinase)-dependent S574 phosphorylated form (p-FOXO3) has been shown to be specifically apoptotic. This study examined whether acetylation and S574 phosphorylation act independently or in concert to regulate the apoptotic function of FOXO3. We observed that both sirtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetylate FOXO3 in vitroand in vivo, and that lipopolysaccharide (LPS) treatment of THP-1 monocytes induced a rapid increase of FOXO3 acetylation, partly by suppression of SIRT1 and SIRT7. Acetylation was required for S574 phosphorylation and cellular apoptosis. Deacetylation of FOXO3 by SIRT activation or SIRT1 or SIRT7 overexpression prevented its S574 phosphorylation and blocked apoptosis in response to LPS. We also found that acetylated FOXO3 preferentially bound JNK1, and a mutant FOXO3 lacking four known acetylation sites (K242, 259, 290 and 569R) abolished JNK1 binding and failed to induce apoptosis. This interplay of acetylation and phosphorylation also regulated cell death in primary human peripheral blood monocytes (PBMs). PBMs isolated from alcoholic hepatitis patients had high expression of SIRT1 and SIRT7 and failed to induce p-FOXO3 and apoptosis in response to LPS. PBMs from healthy controls had lower SIRT1 and SIRT7 and readily formed p-FOXO3 and underwent apoptosis when similarly treated. These results reveal that acetylation is permissive for generation of the apoptotic form of FOXO3 and the activity of SIRT1 and particularly SIRT7 regulate this process in vivo, allowing control of monocyte apoptosis in response to LPS.
Published: 2017
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21. Outcome of Adult Brain Tumor Consortium (ABTC) prospective dose-finding trials of I-125 balloon brachytherapy in high-grade gliomas: challenges in clinical trial design and technology development when MRI treatment effect and recurrence appear similar.

Author: Kleinberg, L., Stieber, V., Mikkelsen, T., Judy, K., Weingart, J., Barnett, G., Olson, J., Desideri, S., Ye, X., and Grossman, S.
Published: 2015
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22. High-power synchronously pumped femtosecond Raman fiber laser.

Author: Churin, D., Olson, J., Norwood, R. A., Peyghambarian, N., and Kieu, K.
Published: 2015
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23. Lockheed Martin Two-Stage Pulse Tube Cryocooler for GIFTS.

Author: Ross, Ronald G., Nast, T., Frank, D., Roth, E., Champagne, P., Olson, J., Evtimov, B., Clappier, R., Renna, T., and Martin, B.
Abstract: Lockheed Martin’s Advanced Technology Center (LM-ATC) is developing the cryocooler system for the Geosynchronous Imaging Fourier Transform Spectrometer (GIFTS). This is a NASA New Millennium Program (NMP) Earth Observing-3 mission to demonstrate revolutionary science enabling technologies. One of the new technologies for future generation remote sensors is the two-stage pulse tube cryocooler. Lockheed Martin is presently fabricating two cryocooler flight models, which includes the cryocooler and electronic controller. LM-ATC’s cryocooler approach employs a unique staging arrangement, which results in high power efficiency, compact, efficient packaging and interfacing and excellent reliability. It is robust and simple, consisting of a two-stage coldhead with no moving parts, driven by a linear flexure-bearing compressor and powered by a high-efficiency electronic controller that includes ripple suppression and vibration cancellation. The design is a “split” system in which the compressor and cold head are separated by a transfer line. The approach allows on orbit adjustment of the relative cooling loads and temperatures of the two stages. The controller provides precise temperature control at 55K. The cryocooler is designed to simultaneously provide cooling of 1.5 W at 55 K and 8 W at 140 K while rejecting heat at 300 K. Total system power is projected to be 150 W, and the exported vibration is expected to be less than 0.2 N. This paper presents the status of the flight model and overall system characteristics. [ABSTRACT FROM AUTHOR]
Published: 2005
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24. Lockheed Martin RAMOS Engineering Model Cryocooler.

Author: Ross, Ronald G., Frank, D., Roth, E., Champagne, P., Olson, J., Evtimov, B., Clappier, R., Nast, T., Renna, T., and Martin, B.
Abstract: Lockheed Martin’s Advanced Technology Center (LM-ATC) is developing the cryocooler system for the United States infrared instrument on the Russian-American Observational Satellites (RAMOS) under contract to the Space Dynamics Laboratory. The project is presently fabricating the engineering model, which consists of the cryocooler and electronic controller. LM-ATC s cryocooler is robust and simple, consisting of a two-stage coldhead with no moving parts, driven by a linear flexure-bearing compressor and powered by a high-efficiency electronic controller that includes ripple suppression and vibration cancellation. A distance of up to one meter separates the coldhead and compressor. The controller provides temperature control at 75K. The cryocooler is designed simultaneously to provide 0.75 W of cooling at 75K and 6 W cooling at 130K while rejecting heat at 313K. Total system power is 117 W and the exported vibration is less then 0.2N. This paper presents the status of the engineering model and overall system characteristics. [ABSTRACT FROM AUTHOR]
Published: 2005
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25. Lockheed Martin 6K/18K Cryocooler.

Author: Ross, Ronald G., Olson, J., Champagne, P., Roth, E., Evtimov, B., Clappier, R., Nast, T., Renna, T., and Martin, B.
Abstract: Under contract with the Jet Propulsion Laboratory (Advanced Cryocooler Technology Development Program), Lockheed Martin’s Advanced Technology Center (LM-ATC) is developing a four-stage pulse tube cryocooler and electronic controller to provide simultaneous cooling at 6 K and 18 K. LM-ATC successfully completed the design phase of the program, where a robust, simple pulse tube cryocooler system was designed to meet JPL’s cryocooler needs. The simplicity of LM-ATC s approach, with a single compressor, coldhead and electronic controller, makes it very appealing for the large observatories (Constellation-X, Terrestrial Planet Finder, and the James Webb Space Telescope) that require high reliability. The cryocooler is designed simultaneously to provide 20 mW of cooling at 6 K and 150 mW cooling at 18 K while conductively rejecting heat at 290K. The Lockheed Martin pulse tube is a simple four-stage coldhead with no moving parts, driven by a linear flexure-bearing compressor, powered by a high-efficiency electronic controller. The controller provides simultaneous temperature control at both 6 K and 18 K, vibration cancellation, and bus current ripple suppression. This paper summarizes the characteristics of the system and the status of the program. [ABSTRACT FROM AUTHOR]
Published: 2005
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26. Design and performance of a large lumen glaucoma drainage device

Author: Olson, J L and Groman-Lupa, S
Abstract: PurposeWe report the in vivo testing of a large-lumen glaucoma drainage (LL-GDD) device equipped with a flow regulator. The device’s membrane can be non-invasively opened with laser in the postoperative period to adjust aqueous flow and intraocular pressure.MethodsThe initial LL-GDD prototypes were constructed using 22 G silicone angiocatheters cut down to size. A 10 nm PVDF membrane was then affixed to the end using cyanoacrylate. The LL-GDD was tested first in a model eye equipped with ports for infusion and pressure measurement and in New Zealand rabbits.ResultsNew Zealand white satin cross rabbits were used, two eyes receiving the LL-GDD and the two fellow eyes serving as the control group with no intervention performed. After the procedure, the IOP in the LL-GGD surgical group dropped an average of 5.5 mm Hg (P=0.001), which was maintained until the membrane laser procedure at week 5 resulting in an average IOP reduction of 1.8 mm Hg. At week 7, the average IOP in the surgical group was 11 mm Hg compared with 18 mm Hg in the control group (P<0.001). A second laser procedure was done to completely open the membrane face, which resulted in an immediate drop in the average IOP of the surgical group by another 2.7 mm Hg, which was maintained until the study termination at day 55.ConclusionsThe large-lumen glaucoma drainage device demonstrated an ability both to prevent immediate postoperative hypotony and to allow progressively lower IOP on demand in this proof-of-concept study.
Published: 2017
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27. Fast cool-down coaxial pulse tube microcooler

Author: Pagano, Thomas S., Nast, T., Olson, J. R., Champagne, P., Roth, E., Kaldas, G., Saito, E., Loung, V., McCay, B. S., Kenton, A. C., and Dobbins, C. L.
Published: 2016
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28. First flight of the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument

Author: den Herder, Jan-Willem A., Takahashi, Tadayuki, Bautz, Marshall, Duncan, Nicole, Saint-Hilaire, P., Shih, A. Y., Hurford, G. J., Bain, H. M., Amman, M., Mochizuki, B. A., Hoberman, J., Olson, J., Maruca, B. A., Godbole, N. M., Smith, D. M., Sample, J., Kelley, N. A., Zoglauer, A., Caspi, A., Kaufmann, P., Boggs, S., and Lin, R. P.
Published: 2016
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29. Fast cooldown coaxial pulse tube microcooler

Author: Dhar, Nibir K., Dutta, Achyut K., Nast, T., Olson, J. R., Champagne, P., Roth, E., Kaldas, G., Saito, E., Loung, V., McCay, B. S., Kenton, A. C., and Dobbins, C. L.
Published: 2016
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30. Outcome of Adult Brain Tumor Consortium (ABTC) prospective dose-finding trials of I-125 balloon brachytherapy in high-grade gliomas: challenges in clinical trial design and technology development when MRI treatment effect and recurrence appear similar

Author: Kleinberg, L., Stieber, V., Mikkelsen, T., Judy, K., Weingart, J., Barnett, G., Olson, J., Desideri, S., Ye, X., and Grossman, S.
Abstract: The aim of this study is to define the maximal safe radiation dose to guide further study of the GliaSite balloon brachytherapy (GSBT) system in untreated newly diagnosed glioblastoma (NEW-GBM) and recurrent high-grade glioma (REC-HGG). GBST is a balloon placed in the resection cavity and later filled through a subcutaneous port with liquid I-125 Iotrex, providing radiation doses that diminish uniformly with distance from the balloon surface. The Adult Brain Tumor Consortium initiated prospective dose-finding studies to determine maximum tolerated dose in NEW-GBM treated before standard RT or after surgery for REC-HGG. Patients were inevaluable if there was progression before the 90-day posttreatment toxicity evaluation point. Ten NEW-GBM patients had the balloon placed, and 2/10 reached the 90 day timepoint. Five REC-HGG enrolled and two were assessable at the 90-day evaluation endpoint. Imaging progression occurred before 90-day evaluation in 7/12 treated patients. The trials were closed as too few patients were assessable to allow dose escalation, although no dose-limiting toxicities (DLTs) were observed. Median survival from treatment was 15.3 months (95 % CI 7.1–23.6) for NEW-GBM and 12.8 months (95 % CI 4.2–20.9) for REC-HGG. These trials failed to determine a maximum tolerated dose (MTD) for further testing as early imaging changes, presumed to be progression, were common and interfered with the assessment of treatment-related toxicity. The survival outcomes in these and other related studies, although based on small populations, suggest that GSBT may be worthy of further study using clinical and survival endpoints, rather than standard imaging results. The implications for local therapy development are discussed.
Published: 2015
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31. High-power synchronously pumped femtosecond Raman fiber laser

Author: Churin, D., Olson, J., Norwood, R. A., Peyghambarian, N., and Kieu, K.
Abstract: We report a high-power synchronously pumped femtosecond Raman fiber laser operating in the normal dispersion regime. The Raman laser is pumped by a picosecond Yb^3+-doped fiber laser. It produces highly chirped pulses with energy up to 18 nJ, average power of 0.76 W and 88% efficiency. The pulse duration is measured to be 147 fs after external compression. We observed two different regimes of operation of the laser: coherent and noise-like regime. Both regimes were experimentally characterized. Numerical simulations are in a good agreement with experimental results.
Published: 2015

32. The Texas Earth and Space Science (TXESS) Revolution: A Model for the Delivery of Earth Science Professional Development to Minority-Serving Teachers.

Author: Ellins, K. K., Snow, E., Olson, H. C., Stocks, E., Willis, M., Olson, J., and Odell, M. R.
Subjects: EARTH science education, SPACE sciences education, CAREER development, SCIENCE teachers, MINORITY teachers, CURRICULUM
Abstract: The Texas Earth and Space Science (TXESS) Revolution was a 5-y teacher professional development project that aimed to increase teachers' content knowledge in Earth science and preparing them to teach a 12th-grade capstone Earth and Space Science course, which is new to the Texas curriculum. The National Science Foundation-supported project was designed around six principles that proved to be critical to in its success: (1) model best practices in workshop presentations, (2) use authentic Earth science data and cybertechnology to teach up-to-date content, (3) provide ongoing training to cohorts of learners over a 2-y period, (4) involve geoscience consortia and programs that can provide proven content for classrooms, (5) use ongoing evaluations to guide future workshops, and (6) provide opportunities for leadership development through participation in research and curriculum development projects. The project served 177 science teachers by supporting them with the pedagogical, technological, and scientific tools to teach modern geoscience. TXESS Revolution teachers directly impacted more than 29,000 students, of which about 69% are nonwhite, by exposing students in Texas to the geosciences and planting the seeds for them to pursue geoscience as a field of study. Using a train-the-trainer approach, TXESS Revolution teachers shared their professional development with other Texas teachers, strengthening Earth science education at all K-12 levels throughout the state, an impact that extends beyond preparation in Earth and space science. [ABSTRACT FROM AUTHOR]
Published: 2013
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33. Stress-Corrosion Cracking as an Alternative Time-Dependent Shale-Stability Model.

Author: Park, N., Olson, J. E., and Holder, J.
Subjects: STRESS corrosion, SHALE, OFFSHORE oil well drilling, HOLES, CHEMISTRY
Abstract: The article discusses the application of the concept of time-dependent cracking to hole enlargement for vertical wellbores through the discrete-element method (DEM) that simulates grain-scale processes. The stress-corrosion model was verified through a published example from the North Sea which demonstrated the application to wellbore stability in shale. Compressive failure is predicted through the analysis of the influence of fluid chemistry and filtrate invasion into the formation.
Published: 2010
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34. Hospital electronic medical record-based public health surveillance system deployed during the 2002 Winter Olympic Games.

Author: Gundlapalli AV, Olson J, Smith SP, Baza M, Hausam RR, Eutropius LJ, Pestotnik SL, Duncan K, Staggers N, Pincetl P, and Samore MH
Abstract: BACKGROUND: Several computer biosurveillance systems are in place to detect events of public health (PH) significance; however, most lack access to timely and detailed patient-level data and investigation of alerts places a strain on PH resources. METHODS: Hospital-based infection control professionals led a multi-disciplinary team to develop a computer rule-based system that relies on the patient's electronic medical record. The rules operated on HL7 messages transmitted by clinical computing systems and encompassed a variety of types of patient-level data, including laboratory test ordering and results, radiology ordering and reports, emergency room and outpatient clinic visits, and hospital admissions. Laboratory data were mapped to standard vocabularies, and radiology data were processed using natural language-processing algorithms before the rules were applied to filter for events of PH interest. For each rule, statistical process controls were applied to generate alerts when levels exceeded two standard deviations above the mean. The system was deployed at a large hospital in Salt Lake City during the 2002 Winter Olympic Games, and it was accessed 3 times a day to perform surveillance. Daily reports were provided to local PH agencies after preliminary investigation of the alerts. RESULTS: Of the 24 rules monitored, 9 generated alerts on 11 different occasions. The only significant event of PH interest that was noted during the surveillance period was an increase in influenza during the Games. The positive predictive value of the rules varied with a high value (89%) noted for identification of pneumonia from chest radiograph reports by natural language-processing algorithms. CONCLUSIONS: With the assistance of a novel computer-based surveillance system linked to the electronic medical record that uses objective, quantifiable events and access to patient data, infection control practitioners could play a front-line role in biosurveillance and facilitate bidirectional communication with PH agencies. [ABSTRACT FROM AUTHOR]
Published: 2007
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35. Infra-red FTS Measurements of CH4, N2O, O3, HNO3, HCl, CFC-11 and CFC-12 from the MANTRA Balloon Campaign.

Author: Fogal, P. F., Blatherwick, R. D., Murcray, F. J., and Olson, J. R.
Subjects: INFRARED radiation, BALLOON gases, MIDDLE atmosphere, NITROGEN, LATITUDE
Abstract: Copyright of Atmosphere - Ocean (Canadian Meteorological & Oceanographic Society) is the property of Canadian Meteorological & Oceanographic Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2005
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36. Patient education. Helping preschoolers become healthy eaters.

Author: Fuller C, Keller L, Olson J, Plymale A, and Gottesman MM
Published: 2005
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37. Policy column. Prescribing syringes to injection drug users with HIV: an important clinical and public health tool.

Author: Stozek MA, Taylor LE, LeBreux L, Olson J, Wolf F, and Rich JD
Published: 2004
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38. Customization of a commercially available prep scale SFC system to provide enhanced capabilities.

Author: Olson J, Pan J, Hochlowski J, Searle P, and Blanchard D
Abstract: Preparative Scale Supercritical Fluid Chromatography is emerging as a powerful alternative to HPLC for the purification and separation of complex chemical reaction mixtures. Advantages include greatly reduced solvent usage (and thus lower cost and environmental impact), higher throughput, and in some cases higher resolution. While there are commercially available prep SFC instruments, none currently offer all the features desired by many medicinal chemists engaged in the drug discovery process. These include: the ability to collect an unlimited number of fractions per sample with high recovery and negligible carryover, fully automated capacity to collect several hundred fractions, and the ability to collect fractions into the same disposable test tubes and racks which are already employed in HPLC. This article describes the customization of a preparatory scale SFC system purchased from Berger Instruments, Inc., Newark, DE. (a subsidiary Mettler-Toledo International, Inc., of Greifensee, Switzerland) in order to provide these capabilities. [ABSTRACT FROM AUTHOR]
Published: 2002
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39. Sustained Pyridoxine Response in Primary Hyperoxaluria Type 1 Recipients of Kidney Alone Transplant

Author: Lorenz, E. C., Lieske, J. C., Seide, B. M., Meek, A. M., Olson, J. B., Bergstralh, E. J., and Milliner, D. S.
Abstract: The authors demonstrate sustained response to pyridoxine therapy following kidney alone transplant in a series of patients with primary hyperoxaluria type 1.
Published: 2014
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40. The Texas Earth and Space Science (TXESS) Revolution: A Model for the Delivery of Earth Science Professional Development to Minority-Serving Teachers

Author: Ellins, K. K., Snow, E., Olson, H. C., Stocks, E., Willis, M., Olson, J., and Odell, M. R.
Abstract: ABSTRACTThe Texas Earth and Space Science (TXESS) Revolution was a 5-y teacher professional development project that aimed to increase teachers' content knowledge in Earth science and preparing them to teach a 12th-grade capstone Earth and Space Science course, which is new to the Texas curriculum. The National Science Foundation–supported project was designed around six principles that proved to be critical to in its success: (1) model best practices in workshop presentations, (2) use authentic Earth science data and cybertechnology to teach up-to-date content, (3) provide ongoing training to cohorts of learners over a 2-y period, (4) involve geoscience consortia and programs that can provide proven content for classrooms, (5) use ongoing evaluations to guide future workshops, and (6) provide opportunities for leadership development through participation in research and curriculum development projects. The project served 177 science teachers by supporting them with the pedagogical, technological, and scientific tools to teach modern geoscience. TXESS Revolution teachers directly impacted more than 29,000 students, of which about 69% are nonwhite, by exposing students in Texas to the geosciences and planting the seeds for them to pursue geoscience as a field of study. Using a train-the-trainer approach, TXESS Revolution teachers shared their professional development with other Texas teachers, strengthening Earth science education at all K–12 levels throughout the state, an impact that extends beyond preparation in Earth and space science.
Published: 2013
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41. Measuring IV Curves and Subcell Photocurrents in the Presence of Luminescent Coupling

Author: Steiner, M. A., Geisz, J. F., Moriarty, T. E., France, R. M., McMahon, W. E., Olson, J. M., Kurtz, S. R., and Friedman, D. J.
Abstract: High-quality, direct-bandgap solar cells emit significant luminescence at their band edge when forced to operate in forward bias, thereby creating a possible source of photocurrent in lower bandgap junctions of a multijunction cell. We study the effects of luminescent coupling on the measurement of the subcell photocurrents for a series-connected III-V multijunction solar cell. We describe a technique that uses a set of light-emitting diodes (LEDs) and a Xenon-lamp white-light source to accurately determine the subcell photocurrents under a reference spectrum, taking the luminescent coupling current into account. The technique quantifies the luminescent coupling efficiencies and compensates for any spectral overlap between the LEDs and the other junctions. Since quantum efficiency curves are used in the adjustment of the simulator spectrum, we also show how to correct those curves to remove the effects of luminescent coupling.
Published: 2013
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42. Metal Pillar Interconnection Topology for Bonded Two-Terminal Multijunction III–V Solar Cells

Author: McMahon, W. E., Lin, C.-T, Ward, J. S., Geisz, J. F., Wanlass, M. W., Carapella, J. J., Olavarría, W., Young, M., Steiner, M. A., France, R. M., Kibbler, A. E., Duda, A., Olson, J. M., Perl, E. E., Friedman, D. J., and Bowers, J. E.
Abstract: Metal-interconnected multijunction solar cells offer one pathway toward efficiencies in excess of 50%. However, if a three- or four-terminal configuration is used, optical losses from the interfacial grid can be considerable. Here, we examine an alternative that provides an optimal interconnection for two-terminal bonded devices. This “pillar-array” topology is optimized by minimizing the sum of all power losses, including shadow losses and numerically computed electrical losses. Numerical modeling is used to illustrate the benefit of a pillar-array interfacial metallization for some two-terminal configurations.
Published: 2013
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43. Pushing Inverted Metamorphic Multijunction Solar Cells Toward Higher Efficiency at Realistic Operating Conditions

Author: France, R. M., Geisz, J. F., Steiner, M. A., Friedman, D. J., Ward, J. S., Olson, J. M., Olavarria, W., Young, M., and Duda, A.
Abstract: A unique aspect of the inverted metamorphic multijunction (IMM) solar cell is the bandgap tunability of each junction, creating extremely flexible device designs. The optimal structure has subcell photocurrents that are matched for a given spectrum. However, the subcell photocurrents depend on the cell operating temperature, and therefore, the bandgaps need to be optimized for a certain range of operating conditions. In addition, imperfect material quality results in a loss of voltage and current that depends on the cell bandgap and thickness. In this case, an iterative process of multijunction design and subcell characterization is necessary to determine the optimal design. We compare two different three-junction devices to demonstrate the effect of bandgap selection and lattice-mismatched material quality on device performance at different temperatures. The triple-junction (3J)-IMM design with two lattice-mismatched junctions of perfect material quality (2MMJ) is theoretically optimal at room temperature but experimentally performs similarly to a simpler design with one mismatched junction (1MMJ) at higher temperature because of material quality tradeoffs and the temperature dependence of the designs. Significant progress in the growth, processing, and measurement has led to a 1MMJ design with (42.6 ± 2.1)% peak efficiency at 327 suns and (40.9 ± 2.0)% efficiency at 1093 suns under the direct spectrum.
Published: 2013
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44. Risk Markers of Juvenile Idiopathic Arthritis-associated Uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry

Author: Angeles-Han, Sheila T., Pelajo, Christina F., Vogler, Larry B., Rouster-Stevens, Kelly, Kennedy, Christine, Ponder, Lori, McCracken, Courtney, Lopez-Benitez, Jorge, Drews-Botsch, Carolyn, Prahalad, Sampath, Abramson, L., Becker, M., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Chalom, E., Dedeoglu, F., Ferguson, P., Goldsmith, D., Gottlieb, B., Graham, T., Griffin, T., Higgins, G., Hollister, J.R., Hsu, J., Huttenlocher, A., Ilowite, N., Imundo, L., Inman, C.J., Jerath, R., Jung, L., Kahn, P., Kingsbury, D., Klein-Gitelman, M., Lehman, T., Lindsley, C., McCurdy, D., Moorthy, N., Muscal, E., Nater, M., Olson, J., O’Neil, K., Onel, K., Prahalad, S., Punaro, M., Quintero, A., Rabinovich, C., Reed, A., Ringold, S., Robinson, A., Rothman, D., Ruth, N., Schikler, K., Sestak, A., Singer, N., Spalding, S., Syed, R., Szer, I., Torok, K., Vehe, R., von Scheven, E., Weiss, J., Weiss, P., White, A., Yalcindag, A., and Zemel, L.
Abstract: Objective.To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and non-Hispanic white (NHW) children.Methods.There were 4983 children with JIA enrolled in the CARRA Registry. Of those, 3967 NHW and AA children were included in this study. Demographic and disease-related data were collected from diagnosis to enrollment. Children with JIA were compared to those with JIA-U. Children with JIA-U were also compared by race.Results.There were 459/3967 children (11.6%) with JIA-U in our cohort with a mean age (SD) of 11.4 years (± 4.5) at enrollment. Compared to children with JIA, they were younger at arthritis onset, more likely to be female, had < 5 joints involved, had oligoarticular JIA, and were antinuclear antibody (ANA)-positive, rheumatoid factor (RF)-negative, and anticitrullinated protein antibody-negative. Predictors of uveitis development included female sex, early age of arthritis onset, and oligoarticular JIA. Polyarticular RF-positive JIA subtype was protective. Nearly 3% of children with JIA-U were AA. However, of the 220 AA children with JIA, 6% had uveitis; in contrast, 12% of the 3721 NHW children with JIA had uveitis.Conclusion.In the CARRA registry, the prevalence of JIA-U in AA and NHW children is 11.6%. We confirmed known uveitis risk markers (ANA positivity, younger age at arthritis onset, and oligoarticular JIA). We describe a decreased likelihood of uveitis in AA children and recommend further exploration of race as a risk factor in a larger population of AA children.
Published: 2013
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45. Using Phase Effects to Understand Measurements of the Quantum Efficiency and Related Luminescent Coupling in a Multijunction Solar Cell

Author: Steiner, M. A., Kurtz, S. R., Geisz, J. F., McMahon, W. E., and Olson, J. M.
Abstract: We analyze the quantum efficiency measurement of a series-connected multijunction solar cell by modeling the cell as an ac resistive-capacitive circuit and studying the complex current as a function of the light biasing. The photocurrent induced by directly absorbed photons is modeled as an independent current source, whereas the luminescent coupling current from higher bandgap to lower bandgap subcells is modeled as a dependent current source in the bottom subcell. We derive expressions for the equivalent impedance and the complex current in measurements of the top and bottom subcells of a two-junction device. High light biasing of the nonlimiting cell drives the magnitude and phase shift of the current toward well-defined limits, but insufficient light biasing yields a composite response that is not fully characteristic of either subcell. We recommend that the experimenter always monitor the phase shift of the signal for signs of insufficient light biasing, and to help identify genuine luminescent coupling effects.
Published: 2012
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46. Differences in Efficacy and Cytokine Profiles following Echinocandin or Liposomal Amphotericin B Monotherapy or Combination Therapy for Murine Pulmonary or Systemic Aspergillus flavusInfections

Author: Olson, J. A., Schwartz, J., Hahka, D., George, A., Proffitt, R. T., and Adler-Moore, J. P.
Abstract: ABSTRACTGiven the recent increase in aspergillosis caused by species other than Aspergillus fumigatus, micafungin, caspofungin, and liposomal amphotericin B (L-AmBi) were investigated as monotherapy or combination therapy for murine systemic or pulmonary Aspergillus flavusinfection. Treatment for 3 or 6 days was begun at 24 h (intravenous [i.v.], 2.8 × 104conidia) or 2 h (intranasal, 4.1 × 106to 6.75 × 106conidia) postchallenge as follows: 5 or 10 mg/kg L-AmBi, 10 mg/kg caspofungin, 15 mg/kg micafungin, L-AmBi plus echinocandin, L-AmBi on days 1 to 3 and echinocandin on days 4 to 6, or echinocandin on days 1 to 3 and L-AmBi on days 4 to 6. Mice were monitored for survival, fungal burden, serum or tissue cytokines, and lung histopathology. In the systemic infection, micafungin or caspofungin was more effective than L-AmBi in prolonging survival (P< 0.05), and L-AmBi was associated with significantly elevated serum levels of interleukin-6 (IL-6), macrophage inflammatory protein 1α (MIP-1α), and IL-12 (P< 0.05). In contrast, L-AmBi was significantly more effective than the echinocandins in reducing fungal growth in most tissues (P< 0.05). Concomitant therapies produced significantly enhanced survival, reduction in fungal burden, and low levels of proinflammatory cytokines, while antagonism was seen with some sequential regimens. In comparison, in the pulmonary infection, L-AmBi was significantly better (P< 0.05) than caspofungin or the combination of L-AmBi and caspofungin in prolonging survival and reducing lung fungal burden. Caspofungin stimulated high lung levels of IL-1α, tumor necrosis factor alpha (TNF-α), and IL-6, with extensive tissue damage. In summary, systemic A flavusinfection was treated effectively with L-AmBi plus micafungin or caspofungin provided that the drugs were administered concomitantly and not sequentially, while pulmonary A. flavusinfection responded well to L-AmBi but not to caspofungin.
Published: 2011
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47. Guidelines for the Diagnosis of Antibody‐Mediated Rejection in Pancreas Allografts—Updated Banff Grading Schema

Author: Drachenberg, C. B., Torrealba, J. R., Nankivell, B. J., Rangel, E. B., Bajema, I. M., Kim, D. U., Arend, L., Bracamonte, E. R., Bromberg, J. S., Bruijn, J. A., Cantarovich, D., Chapman, J. R., Farris, A. B., Gaber, L., Goldberg, J. C., Haririan, A., Honsová, E., Iskandar, S. S., Klassen, D. K., Kraus, E., Lower, F., Odorico, J., Olson, J. L., Mittalhenkle, A., Munivenkatappa, R., Paraskevas, S., Papadimitriou, J. C., Randhawa, P., Reinholt, F. P., Renaudin, K., Revelo, P., Ruiz, P., Samaniego, M. D., Shapiro, R., Stratta, R. J., Sutherland, D. E. R., Troxell, M. L., Voska, L., Seshan, S. V., Racusen, L. C., and Bartlett, S. T.
Abstract: The first Banff proposal for the diagnosis of pancreas rejection (Am J Transplant 2008; 8: 237) dealt primarily with the diagnosis of acute T‐cell‐mediated rejection (ACMR), while only tentatively addressing issues pertaining to antibody‐mediated rejection (AMR). This document presents comprehensive guidelines for the diagnosis of AMR, first proposed at the 10th Banff Conference on Allograft Pathology and refined by a broad‐based multidisciplinary panel. Pancreatic AMR is best identified by a combination of serological and immunohistopathological findings consisting of (i) identification of circulating donor‐specific antibodies, and histopathological data including (ii) morphological evidence of microvascular tissue injury and (iii) C4d staining in interacinar capillaries. Acute AMRis diagnosed conclusively if these three elements are present, whereas a diagnosis of suspicious for AMRis rendered if only two elements are identified. The identification of only one diagnostic element is not sufficient for the diagnosis of AMR but should prompt heightened clinical vigilance. AMR and ACMR may coexist, and should be recognized and graded independently. This proposal is based on our current knowledge of the pathogenesis of pancreas rejection and currently available tools for diagnosis. A systematized clinicopathological approach to AMR is essential for the development and assessment of much needed therapeutic interventions.
Published: 2011
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48. A case of severe hidradenitis suppurativa contributing to a death and a review of the literature.

Author: Groginsky, Elisabeth M., Olson, John K., Lallas, Thomas A., Buekers, Thomas E., Potts, Scot, Sorosky, Joel I., Groginsky, E M, Olson, J K, Lallas, T A, Buekers, T E, Potts, S, and Sorosky, J I
Subjects: DISEASE complications, DENDRITIC cells, INFLAMMATION, HISTOPATHOLOGY
Abstract: Objective: Our aim was to report a fatal complication of hidradenitis suppurativa and a review of the literature.Materials and Methods: A case of severe hidradenitis suppurativa obscuring the diagnosis and precluding the treatment of a ruptured sigmoid diverticulum is presented.Results: We describe a 48-year-old woman who had a long history of untreated hidradenitis suppurativa with extensive vulvar involvement and poor nutritional status. The advanced state of her disease on initial presentation led directly to her death.Conclusion: Although it is a treatable disease, hidradenitis suppurativa can lead to systemic sequelae severe enough to contribute directly to death. [ABSTRACT FROM AUTHOR]
Published: 1999
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49. Are patients willing to incur out-of-pocket costs for pharmacogenomic testing?

Author: Bielinski, S J, St Sauver, J L, Olson, J E, Wieland, M L, Vitek, C R, Bell, E J, Mc Gree, M E, Jacobson, D J, McCormick, J B, Takahashi, P Y, Black, J L, Caraballo, P J, Sharp, R R, Beebe, T J, Weinshilboum, R M, Wang, L, and Roger, V L
Published: 2017
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50. Changes in International Normalized Ratio (INR) and Model for Endstage Liver Disease (MELD) Based on Selection of Clinical Laboratory

Author: Trotter, J. F., Olson, J., Lefkowitz, J., Smith, A. D., Arjal, R., and Kenison, J.
Abstract: Priority for liver transplantation is based on the Model for Endstage Liver Disease (MELD) score, a mathematical function which includes international normalized ratio (INR). We present an analysis to determine the lab-to-lab variation in INR at 14 clinical laboratories across the United States. We performed a survey to identify representative clinical laboratories across the United States, where INR was measured in the determination of MELD score. Five 'standard' samples for INR were formulated and were sent to the 14 clinical laboratories to determine variation in INR and MELD score. Among the 14 clinical laboratories, the range in INR for the five samples was: sample 1 (1.2-2.0), sample 2 (1.4-2.5), sample 3 (1.7-3.4), sample 4 (1.9-3.7) and sample 5 (2.4-5.1). The range in calculated MELD score was: sample 1 (8-14), sample 2 (10-17), sample 3 (12-20), sample 4 (14-21) and sample 5 (16-25). The selection of the clinical laboratory used to determine INR may result in substantial changes in MELD score independent of severity-of-illness. These data suggest that further review of interlaboratory variation in MELD should be undertaken because of the potential impact on prioritization for liver transplantation.
Published: 2007
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