2,703 results on '"Oh, D."'
Search Results
2. Association of low serum 25-Hydroxy vitamin D [25(OH) d] with hepatic encephalopathy in patients with decompensated liver cirrhosis.
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Mumit Sarkar, Abdul, Al Mukit, Abdullah, Bari, Tanzilul, Islam, Rofiqul, Islam, Shafiqul, Sarker, Khalequzzaman, Chowdhury, Manzurul, Harun Or Rashid, Mohd., and Alim, Abdul
- Abstract
The mechanism of hepatic encephalopathy is complex and has not been conclusively established. Recent studies support lower serum 25-Hydroxy Vitamin D [25(OH) D] levels in patients with hepatic encephalopathy. This study aimed to evaluate the association between serum 25(OH) D and hepatic encephalopathy in patients with decompensated cirrhosis of liver. A total of 70 cirrhosis patients (35 cases of hepatic encephalopathy and 35 patients without encephalopathy as control, mean age 53.07 ± 12.99 years, 67 % male) were recruited for this study. Assessment of the severity of cirrhosis was done by using a model for end-stage liver disease(MELD) and Child Turcotte Pugh (CTP) scores, and assessment of the severity of hepatic encephalopathy was done according to West Haven criteria. Serum 25 (OH) D level was measured by Chemiluminescent Microparticle Immuno Assay(CMIA). The mean serum 25(OH) D level among hepatic encephalopathy patients was significantly lower in comparison to the control group without encephalopathy (18.76 ± 8.84 nmol/L vs 31.19 ± 13.9 nmol/L, P <0.0001). 91.4 % of hepatic encephalopathy patients had moderate to severe 25(OH)D deficiency as compared to 51.4 % in the control group. There was a significant correlation observed between the severity of the 25 (OH) D deficiency and the severity of liver disease (r = − 0.35, P = 0.002). No statistically significant difference in serum 25(OH) D levels was found among patients with different hepatic encephalopathy grades (P = 0.416). A significant association was found between a low serum 25(OH) D leveland hepatic encephalopathy. It requires further large-scale multicenter studies to establish it as a risk factor and predictor of hepatic encephalopathy. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Circulating total 25(OH)D and calculated free 25(OH)D in professional academy footballers at a northerly latitude in the UK.
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Bowles, Simon D., Basu, Subhashis, Ranchordas, Mayur K., Simper, Trevor, and Lynn, Anthony
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There is limited data on the vitamin D status of UK-based professional academy footballers. Therefore, the objective of this study was to report total 25(OH)D, free 25(OH)D and free 1, 25(OH)2D at the end of the winter (March) and summer periods (October) in a cohort (n = 27) of professional academy footballers in northern England. Blood samples were collected to measure total 25(OH)D, parathyroid hormone, vitamin D binding protein, albumin and calcium. Free 25(OH)D and 1, 25(OH)2D were calculated. Dietary vitamin D intake and retrospective summer sunlight exposure were also collected. At the end of winter, 2/27 (7.4%) players were vitamin D deficient (25(OH)D < 30 nmol/l) and 11/27 (40.7%) were insufficient (25(OH)D > 30 nmol/l < 50 nmol/l). By the end of summer, none were deficient but 3/14 (21.4%) were still insufficient. Median total 25(OH)D (82.2 nmol/l [IQR: 50.3-90.2] vs. 54.2 nmol/l [IQR: 36.8-71.9]; P = .02), free 25(OH)D (25.8 pmol/l [IQR: 15.1-33.1] vs. 13.2 pmol/l [IQR: 9.0-14.9]; P = .005) and free 1, 25(OH)2D (389 fmol/l [IQR: 209-594] vs. 212 fmol/l [IQR: 108-278]; P = .034) were significantly higher at the end of summer than the end of winter. At the end of winter, free 25(OH)D was lower (P = .003) in those vitamin D insufficient (8.8 pmol/l [IQR: 5.5-11.8]) vs. sufficient (13.7 pmol/l [IQR: 12.0-17.0]). There was a high prevalence of vitamin D insufficiency at the end of the winter. Free 25(OH)D was also lower at the winter timepoint and in players that were insufficient vs. sufficient. [ABSTRACT FROM AUTHOR]
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- 2024
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4. The saturation effect of 25(OH)D level on sleep duration for older people:The NHANES 2011–2018.
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Duan, Ran, Feng, Tong, Hou, JiXin, Wei, Yu, and Lin, Lin
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• In this study of individuals aged over 60 years, we demonstrated the positive association between 25(OH)D with sleep duration. • Of note, a 25(OH)D saturation value (40.6 ng/mL) was discovered in the sleep duration in all subjects. • At 25(OH)D levels 40.6 ng/mL, the increase in sleep duration was greater as a 25(OH)D increased, whereas at 25(OH)D levels above 40.6 ng/mL, the increase was not significant, which is important for maintaining optimal sleep duration. This study aimed to investigate the potential relationship between vitamin D and sleep duration in older adults. The study utilized multivariate linear regression models to estimate the associations between serum 25(OH)D and sleep duration. In addition, a smooth curve fitting approach was used to identify any non-linear trends between the two variables. The study included 15,749 participants over the age of 60. The results showed a positive correlation between serum 25(OH)D levels and sleep duration in the fully-adjusted model. This correlation was observed in both males and females, as well as in non-Hispanic White and non-Hispanic Black participants. No significant interactions were found between serum 25(OH)D levels and the stratifying variables. The curve fitting analysis revealed a non-linear relationship between 25(OH)D and sleep duration, with a saturation point observed at a serum 25(OH)D level of 40.6 ng/mL. In conclusion, the findings suggest that there is a positive correlation between serum 25(OH)D levels and sleep duration, with a saturation effect observed. A positive correlation is evident when serum 25(OH)D falls below 40.6 ng/mL. [ABSTRACT FROM AUTHOR]
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- 2023
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5. The association between serum 25(OH)D levels and neuromyelitis optica spectrum disorder: The importance of prediction intervals in meta-analysis interpretation.
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Chen, I-Wen, Liu, Wei-Cheng, and Hung, Kuo-Chuan
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• Liu et al. found lower 25(OH)D in NMOSD patients based on six studies. • Prediction intervals suggest a more conservative future effect estimate. • Prediction interval crossing zero shows inconsistent 25(OH)D-NMOSD link. • More research is needed to confirm the 25(OH)D-NMOSD link. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Niveles de 25(OH)D durante la pandemia de COVID-19: impacto del confinamiento y la radiación ultravioleta.
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Ramírez-Stieben, Luis A., Nollas, Fernando, Gloria, Suita, Belardinelli, Marina V., Pustilnik, Estefanía, Bolzán, Diamela, and Feldman, Rodolfo N.
- Abstract
Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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7. VITAMIN D SUPPLEMENTATION: EFFECT ON THE 25(OH) D PROFILE AND OCCURRENCE OF MUSCLE INJURIES IN PROFESSIONAL SOCCER ATHLETES.
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de Jesus Modesto, Marilza and de Lacerda, Luiz
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DIETARY supplements ,VITAMIN D ,MUSCLE injuries ,ATHLETES ,PROFESSIONAL athletes ,ADIPOSE tissues - Abstract
Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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8. Correlation between serum 25(OH)D and cognitive impairment in Parkinson's disease.
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Wu, Han, Khuram Raza, Hafiz, Li, Zhen, Li, Zeheng, Zu, Jie, Xu, Chuanying, Yang, Di, and Cui, Guiyun
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• A prospective, observational, cross-sectional cohort study for Parkinson's disease. • Serum 25(OH)D associated with cognitive impairment in Parkinson's disease patients. • Serum 25(OH)D is a biomarker of cognitive impairment in Parkinson's disease. This study aimed to investigate the relationship between serum 25(OH)D and cognitive impairment in patients with Parkinson's disease (PD), hoping to provide possible ideas for the diagnosis and prevention of PD with cognitive impairment. Vitamin D is a neurosteroid with neurotrophic and neuroprotective functions, playing an important role in PD and its progression. In the present study, serum 25(OH)D levels were significantly decreased in PD patients (45.86 ± 14.81 nmol/L)compared to healthy controls(56.54 ± 14.00 nmol/L) (P < 0.001), and significant differences were also observed in PD patients with normal cognition (PD-NC), PD patients with mild cognitive impairment (PD-MCI)and PD patients with dementia (PDD)(P < 0.05). Moreover, there was a positive correlation between serum 25(OH)D levels and Montreal cognitive assessment(MoCA) scores (r = 0.489, P < 0.001).The increased serum 25(OH)D was an independent protective factor of cognitive impairment in PD (OR = 0. 949, P = 0.005), and the sensitivity, specificity, and AUC under the ROC curve area of serum 25(OH)D were 53.3%, 86.5%, and 0.713, respectively. These findings support the relationship between cognitive impairment and Vitamin D in PD patients. Serum 25(OH)D may be a useful biomarker for diagnosing cognitive impairment in patients with PD. [ABSTRACT FROM AUTHOR]
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- 2022
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9. 25(OH)D level and vascular lesion scores in kidney histopathology as risk-stratification tool for predicting renal progression in people with type 2 diabetes.
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Duan, Suyan, Lu, Fang, Sun, Rui, Chen, Chen, Chen, Si, Geng, Luhan, Qian, Li, Pan, Ying, Zhang, Chengning, Zeng, Ming, Sun, Bin, Mao, Huijuan, Zhang, Bo, Xing, Changying, and Yuan, Yanggang
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To evaluate the potential of the combined individual vascular histopathological lesion and serum 25-hydroxy vitamin D [25(OH)D] level as predictors of outcomes in patients with diabetes and chronic kidney disease. A total of 190 patients with type 2 diabetes and kidney disease stages 1–4 were retrospectively included. Kaplan-Meier analysis and the log-rank test were performed to assess renal survival differences. And the time-dependent receiver operating characteristic analyses were used to characterize the predictive accuracy. Hazard ratios for vascular lesion scores and 25(OH)D levels with renal outcomes were estimated using Cox proportional hazards regression models with follow-up time. Over a median follow-up of 23.78 (12.61, 37.14) months, 71 patients (37.4 %) experienced the renal outcomes. Enrolled patients with more severe vascular lesions had worse kidney function, heavier proteinuria, lower serum 25(OH)D levels, and higher prevalence of composite kidney outcomes. Baseline serum 25(OH)D was a significant independent risk factor for vascular lesion scores. The effect of serum 25(OH)D level on kidney prognosis was more pronounced in males and those with more exacerbated vascular lesions (score 2). The severity of vascular lesions and serum 25(OH)D levels were associated with unfavorable kidney outcomes. Accordingly, further time-dependent receiver operating characteristic curves confirmed that combined 25(OH)D level and vascular lesion score had a stable and reliable performance in renal outcomes prediction at short and long-term follow-up times. 25(OH)D level and vascular lesion scores in kidney histopathology could serve as a useful risk-stratification tool for predicting renal progression in patients with type 2 diabetes. • 25-hydroxy vitamin D level was an independent risk factor of vascular lesions in type 2 diabetes with CKD. • The severity of vascular lesions and serum 25-hydroxy vitamin D levels were significantly associated with kidney outcomes. • 25-hydroxy vitamin D level was a useful risk-stratification tool for predicting CKD progression in type 2 diabetes. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Associations of Serum 25(OH)D With Risk of Recurrent Cardiovascular Events in Individuals With Coronary Heart Disease
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Lin, Xiaoyu, Chen, Xue, Liu, Sen, Deng, Yulei, Wang, Yuexuan, Lu, Qi, Li, Rui, Ou, Yunjing, Tian, Qingying, Liao, Yunfei, Cui, Guanglin, Yang, Kun, Pan, An, and Liu, Gang
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- 2023
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11. The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial.
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Wyon, M.A., Wolman, R., Martin, C., and Galloway, S.
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The use of vitamin D supplementation has increased due to greater recognition of widespread deficiency. There has been little research on the effectiveness of different delivery methods and therefore the aim of was to test the efficacy of different delivery methods on serum 25(OH)D. Using a randomised repeated measures double-blind placebo design (registered under ClinicalTrials.gov Identifier no. NCT03463642), changes in serum 25(OH)D over a 4-week period using a capillary spot method were monitored. 62 female participants blindly chose a number related to a supplementation delivery method: pill placebo, pill, oral liquid, oral liquid placebo, Skin oil application (SOA) placebo, SOA plus vitamin D 3 suspension, or SOA plus vitamin D 3 suspension with essential oil enhancer; active vitamin D supplements contained 100,000IU. Participants took their allocated supplements over a 24-hr period with serum 25(OH)D retested 4 weeks later. Liquid chromatography-tandem mass spectrometry method was applied to dried blood spot samples by an independent laboratory. ANCOVA reported a significant difference between the groups (F 1,6 = 146.68; p < 0.001, eta
2 = 0.51). Separate analysis within the delivery methods (pill, SOA, oral liquid) indicated significant differences between the active and placebo supplementation groups (p < 0.01). Post hoc analysis of absolute changes indicated vit D pill and SOA + vit D + essential oil had significant increases (p < 0.05) in serum 25(OH)D compared to all other interventions with no significant difference between them. In human participants vitamin D oral pill has the greatest effect on serum 25(OH)D levels. Skin oil application delivery of vitamin D using a penetrator enhancer has also been shown to be an effective method of delivery. [ABSTRACT FROM AUTHOR]- Published
- 2021
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12. Bioavailable 25(OH)D level is associated with clinical outcomes of patients with diffuse large B-cell lymphoma: An exploratory study.
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Chen, Peizhan, Cao, Yiwen, Duan, Xiaohua, Li, Jingquan, Zhao, Weili, and Wang, Hui
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Vitamin D insufficiency is associated with worse clinical outcomes in multiple cancer types; however, its roles in diffuse large B-cell lymphoma (DLBCL) patients are still unclear. Here, we aimed to determine the prognostic values of circulating total 25(OH)D and bioavailable 25(OH)D levels in DLBCL patients. A total of 332 newly diagnosed DLBCL patients were recruited. The plasma total 25(OH)D and bioavailable 25(OH)D levels at diagnosis were determined, and their associations with the clinical characteristics and the prognosis of patients were evaluated. The predictive values of clinical characteristics and 25(OH)D levels in the responses to R–CHOP treatments in DLBCL patients were also assessed. Of the patients, 92.8% had insufficient vitamin D status (<30 ng/mL). Patients with higher plasma bioavailable 25(OH)D were associated with better progression-free survival (PFS, multivariate adjusted-HR = 0.72, 95% CI = 0.38–1.35, P = 0.301, Tertile 2 vs. 1; multivariate adjusted-HR = 0.39, 95% CI = 0.20–0.79, P = 0.009, Tertile 3 vs. 1) and overall survival (OS, multivariate adjusted-HR = 0.89, 95% CI = 0.39–2.02, P = 0.777, Tertile 2 vs. 1; multivariate adjusted-HR = 0.21, 95% CI = 0.07–0.65, P = 0.007, Tertile 3 vs. 1). Meanwhile, higher plasma total 25(OH)D level was significantly associated with better PFS but not OS in DLBCL patients. Besides, DLBCL patients with higher total or bioavailable 25(OH)D levels were more sensitive to the R–CHOP regimen treatments. The bioavailable 25(OH)D level may serve as a novel prognostic biomarker in DLBCL patients. • DLBCL patients with higher bioavailable 25(OH)D level are associated with better prognosis. • Blood 25(OH)D levels are negatively correlated with IPI factors in DLBCL patients. • DLBCL patients with higher blood 25(OH)D levels are more sensitive to R–CHOP treatments. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Comparison of Saliva and Serum Total 25(OH)D Levels in Young Children: A Pilot Study.
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Hussein, Alaa Sabah, Almoudi, Manal Mohamed, Abu-Hassan, Mohamed Ibrahim, Schroth, Robert J., Saripudin, Bahruddin, and Chinna, Karuthan
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SALIVA ,VITAMIN D deficiency ,SALIVA analysis ,ENZYME-linked immunosorbent assay ,SERUM - Abstract
Vitamin D deficiency is associated with different health conditions including dental caries in children. This pilot study aimed to assess 25-hydroxyvitamin D [25(OH)D] levels in saliva of young children and investigate the possible association between saliva and serum total 25(OH)D levels. A total of 25 healthy children were enrolled in this study. Paired serum and unstimulated whole saliva samples were collected from each child. Serum and saliva values of total 25(OH)D levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA) kit. Descriptive statistics, bivariate and Pearson's correlation analysis were performed. The significance level for alpha was set at 0.05. Two children had deficient serum 25(OH)D while seven children had deficient levels of 25(OH)D when measured from saliva. The mean 25(OH)D level were higher in serum compared to saliva (25.66±9.52 ng/mL vs. 23.38±13.92 ng/mL). However, the difference was not significant (p=0.306). There was a significant association between serum and saliva 25(OH)D levels (r2 = 0.626.; p < 0.001). Saliva analysis of 25(OH)D yielded lower levels than serum samples. The findings revealed a positive correlation between serum and saliva values of total 25(OH)D suggesting saliva 25(OH)D may potentially be used as screening test for vitamin D status in young children. [ABSTRACT FROM AUTHOR]
- Published
- 2020
14. Association Between 25(OH)D Levels and Primary Arterial Hypertension
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Požarskis, Anatolijs, Požarska, Rita, and Baranovska, Ļubova
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This study seeks to determine whether patients from a family physician’s practice have an association between 25(OH)D levels and primary arterial hypertension (AH). The study included a total of 1068 patients who were tested for vitamin D status. Data from their outpatient medical records were analysed: sex, age, body mass index, glomerular filtration rate, and the history of AH. Primary arterial hypertension was diagnosed in 63% of the patients. The mean vitamin D level in the study population was 25 ng/ml, and the largest group, or 36%, was found to have vitamin D deficiency (20–29 ng/ml). Odds ratio (OR) for hypertension was not inversely correlated with higher vitamin D levels. No statistically significant increase was observed in OR in a multi-factor analysis. The relevant hypertension ORs were 1.8 (0.4–7.5), 1.1 (0.3–4.5), 1.7 (0.4–7.2) and 0.7 (0.1–4.8) 30 ng/ml to 45 ng/ml, 20 to 29 ng/ml, 10 to 19 ng/ml, and < 10 ng/ml compared to the group of ³ 45 ng/ml. No association was found between 25(OH)D levels and the primary arterial hypertension in study participants.
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- 2023
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15. Levels of bioavailable, and free forms of 25(OH)D after supplementation with vitamin D3in primary hyperparathyroidism
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dos Santos, Lívia Marcela, Ohe, Monique Nakayama, Pallone, Sthefanie Giovanna, Nacaguma, Isabela Ohki, Kunii, Ilda Sizue, da Silva, Renata Elen Costa, Maeda, Sergio Setsuo, Vieira, José Gilberto Henriques, and Lazaretti-Castro, Marise
- Abstract
The 25 hydroxyvitamin D [25(OH)D] is the major metabolite for ascertaining vitamin D status, which circulates bound to a specific carrier (vitamin D-binding protein - VDBP). A portion that circulates unbound vary according to the VDBP genotype. This study evaluates the behavior of different forms of 25(OH)D, before and after supplementation with 14,000 IU of vitamin D3, weekly for 12 weeks, in individuals with primary hyperparathyroidism and controls. Fifty-six patients with active primary hyperparathyroidism (PHPT) and 64 paired controls (CTRL), not taking vitamin D3 for the last three months, were enrolled. The genetic isotypes of VDBP were determined to calculate bioavailable and free 25(OH)D. A p<0.05 was considered significant. There were no statistical differences in free, bioavailable, and total 25(OH)D levels between PHPT and CTRL groups at baseline. The distribution of VDBP haplotypes 1s/1s, 1f/1f, 1s/1f, 2/2, 1s/2, and 1f/2 was similar between groups. After supplementation, all three forms of 25(OH)D proportionally increased within each group, although the percentage increment was lower in the PHPT group (p< 0.05). Total 25(OH)D is better correlated with PTH in the PHPT group than bioavailable and free 25(OH)D (r= −0.41; p< 0.05). The concentrations of total, free, and bioavailable 25(OH)D were similar in both PHPT and CTRL groups, and all forms increased proportionally after supplementation, although this increment percentage was higher in the CTRL group, with a subsequent reduction of PTH and AP. Total 25(OH)D correlated better with PTH than other forms, suggesting no advantages in measuring free or bioavailable 25(OH)D in these situations.
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- 2023
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16. Threshold of 25(OH)D and consequently adjusted parathyroid hormone reference intervals: data mining for relationship between vitamin D and parathyroid hormone
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Gong, M., Wang, K., Sun, H., Wang, K., Zhou, Y., Cong, Y., Deng, X., and Mao, Y.
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Purpose: By recruiting reference population, we aimed to (1): estimate the 25(OH)D threshold that maximally inhibits the PTH, which can be defined as the cutoff value for vitamin D sufficiency; (2) establish the PTH reference interval (RI) in population with sufficient vitamin D. Methods: Study data were retrieved from LIS (Laboratory Information Management System) under literature suggested criteria, and outliers were excluded using Tukey fence method. Locally weighted regression (LOESS) and segmented regression (SR) were conducted to estimate the threshold of 25(OH)D. Multivariate linear regression was performed to evaluate the associations between PTH concentration and variables including 25(OH)D, gender, age, estimated glomerular filtration rate (EGFR), body mass index (BMI), albumin-adjusted serum calcium (aCa), serum phosphate(P), serum magnesium(Mg), and blood collection season. Ztest was adopted to evaluate whether the reference interval should be stratified by determinants such as age and gender. Results: A total of 64,979 apparently healthy subjects were recruited in this study, with median (Q1, Q3) 25(OH)D of 45.33 (36.15, 57.50) nmol/L and median (Q1, Q3) PTH of 42.19 (34.24, 52.20) ng/L. The segmented regression determined the 25(OH)D threshold of 55 nmol/L above which PTH would somewhat plateau and of 22 nmol/L below which PTH would rise steeply. Multivariate linear regression suggested that gender, EGFR, and BMI were independently associated with PTH concentrations. The PTH RI was calculated as 22.17–72.72 ng/L for subjects with 25(OH)D ≥ 55 nmol/L with no necessity of stratification according to gender, age, menopausal status nor season. Conclusion: This study reported 25(OH)D thresholds of vitamin D sufficiency at 55 nmol/L and vitamin D deficiency at 22 nmol/L, and consequently established PTH RIs in subjects with sufficient vitamin D for northern China population for the first time.
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- 2023
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17. The role of baseline serum 25(OH)D concentration for a potential personalized vitamin D supplementation
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Ferrario, Paola G., Watzl, Bernhard, and Ritz, Christian
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There are many examples in clinical nutrition with individuals responding differently to a dietary intervention. Here, personalized nutritional recommendations could be targeted, tailoring interventions to address plurality in response. For this, we reconsidered two randomized controlled trials investigating whether two different supplementation doses of cholecalciferol resulted in an increased serum 25(OH)D concentration. Three different statistical methods were applied in order to identify participants who would enjoy an increased benefit from receiving a specific dose of cholecalciferol. We concluded that, for individuals with high baseline serum 25(OH)D concentrations, only the high supplementation dose will lead to a substantial increase in the serum 25(OH)D concentration. The presented statistical methods can be adequately used for more individualized approaches.
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- 2022
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18. Findings from Xuzhou Medical University in the Area of Epilepsy Described [Correlation Analysis of 25(Oh)D With Cognitive Function In Epilepsy Patients: a Cross-sectional Study].
- Abstract
A study conducted by researchers at Xuzhou Medical University in Jiangsu, China, examined the correlation between the level of 25(OH)D in peripheral blood and cognitive function in patients with epilepsy. The study included 68 epilepsy patients and 30 healthy subjects. The results showed that the levels of 25(OH)D and cognitive function were significantly lower in the epilepsy group compared to the healthy control group. Logistic regression analysis indicated that serum 25(OH)D level was an independent risk factor for epilepsy combined with cognitive impairment. The researchers concluded that decreased levels of vitamin D may be a biomarker for early screening of cognitive impairment associated with epilepsy. [Extracted from the article]
- Published
- 2024
19. Level of vitamin 25 (OH) D and B group vitamins and functional efficiency among the chronically ill elderly in domiciliary care – a pilot study.
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Kocka, Katarzyna Halina, Ślusarska, Barbara Janina, Nowicki, Grzegorz Józef, Bartoszek, Agnieszka Barbara, Rudnicka-Drożak, Ewa Anna, Panasiuk, Lech, and Kocki, Tomasz
- Abstract
Introduction and objective. Deficits of vitamin resources constitute a significant public health problem, especially among the elderly population. The aim of the research was to determine the level of vitamin 25 (OH) D and vitamins from group B in the chronically ill elderly in domiciliary care, depending on functional capacity and coexisting diseases. Materials and method. The pilot study included 137 patients staying in long-term domiciliary care. Samples of the participants’ venous blood was obtained for laboratory tests. Centrifuged serum was used to determine the level of the following biochemical parameters: vitamin 25 (OH)D, B12, folic acid and total protein, albumin, triglycerides, total cholesterol and HDL cholesterol. Assessment of the functional status of patients was made by using the Barthel scale. Results. More than ¾ of the patients with functional deficit (according to Barthel’s score 0–85 points) were deficient in vitamin 25 (OH)D, while folic acid values were below the reference values in more than half of the patients. Respondents with lower functional efficiency were characterised by a reduced average value of vitamin 25 (OH)D and folic acid. Conclusions. The studied group of the chronically ill elderly was characterised by a deficiency of vitamin D3 and folic acid. Subjects with a functional impairment deficit show a reduced mean value of vitamin 25 (OH)D and folic acid in the blood serum, compared to the group of patients with higher mobility. [ABSTRACT FROM AUTHOR]
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- 2019
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20. Exploring possible relationships between 25(OH)D deficiency and variables related to inflammation, endothelial function, and enzymatic antioxidants in adolescent athletes: a prospective study.
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Varamenti, Evdokia, Cherif, Anissa, Nikolovski, Zoran, Tabben, Montassar, Jamurtas, Athanasios Z., and Cardinale, Marco
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Although the role of vitamin D in calcium and bone metabolism is well documented, there is little clarity regarding the implications of low vitamin D status for inflammation, endothelial function, and antioxidant status in adolescent athletes. A prospective cohort study was conducted, and 44 male adolescent athletes, training at a sports academy in the Middle East, were assigned to either the intervention group (VitDs), consisting of vitamin D deficient athletes [twenty-five hydroxyvitamin D (25(OH)D) <20 ng/ml; n = 22], or the comparison group, consisting of vitamin D sufficient athletes [25(OH)D >30 ng/ml; n = 22]. Vitamin D status, inflammatory cytokines, endothelium-related variables, and antioxidant enzymes were measured twice during a nine-week training period. At the baseline, the athletes in the VitDs group had significantly lower concentrations of 25(OH)D, vascular endothelial growth factor (VEGF), and glutathione peroxidase (GPx), and higher levels of parathyroid hormone (PTH), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1 ra), and nitrite (NO2) (p < 0.05), in comparison to the athletes in the sufficient group. After vitamin D supplementation for the VitDs group, the two cohorts differed considerably in vitamin D binding protein (VDBP) and PTH concentrations (p < 0.05). Our data suggest that the low levels of vitamin D possibly induced alterations in the investigated biochemical parameters of athletes in the VitDs group at the beginning of the monitoring period. Furthermore, while the vitamin D supplementation was effective in increasing 25(OH)D status, it may have concurrently positively influenced variables that are related to inflammation, endothelial function, and enzymatic antioxidants. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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21. Study Results from University Indonesia in the Area of Biomedicine Published [Urinary PYD/Creatinine Ratio Has Negative Correlation to Serum 25(OH)D and Positive Correlation to Chronic Lead Exposure Index].
- Abstract
A study conducted by researchers at the University Indonesia explores the correlation between lead exposure and bone damage. The study involved 104 workers exposed to lead, and the researchers found a significant negative correlation between serum 25(OH)D levels (a form of vitamin D) and the urinary PYD/creatinine ratio, which is an indicator of bone damage. Additionally, there was a significant positive correlation between chronic lead exposure and the urinary PYD/creatinine ratio. The researchers suggest that pyridinoline may be a potential biomarker for detecting bone metabolism disorders caused by chronic lead exposure, and emphasize the importance of vitamin D adequacy in preventing such disorders. [Extracted from the article]
- Published
- 2024
22. The association of 25(OH)D levels and hippocampal morphology in a clinically mixed sample.
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Dogan, Melike Karacam, Karakaşlı, Ahmet Alp, Özkan, Esra, Türkoğlu, Özge, Yalcinkaya, Oguz Kaan, Oytun, Merve Güner, Zengin, Hatice Yağmur, Doğu, Burcu Balam, Karaosmanoğlu, Ayça, Karahan, Sevilay, Topçuoğlu, Esen Saka, and Ayhan, Yavuz
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Background: 25(OH)D may play role in differentiation and development of the hippocampus(1).25(OH)D deficiency was associated with reduced hippocampal volume in mild cognitive impairment(MCI)(2).We previously have shown that 25(OH)D levels were independently associated with reduced cognition independent from disease and AD‐related morphological changes(3),however the association with hippocampal subfields was not studied.We aimed to study the possible association between hippocampal subvolumes and 25(OH)D levels in our middle‐old age research participants. Method: The participants were collected from a cognitive disorders research clinic at Hacettepe University.Those who use 25(OH)D supplements at the evaluation,have renal failure or diseases that could affect 25(OH)D metabolism were excluded.Concurrent serum 25(OH)D levels,Modified Mini Mental Test(3MS) scores and brain MRI data were retrospectively analyzed.FreeSurfer v.6.0 was used for automated structural neuroimaging analysis.Desikan‐Killiany atlas was utilized and in addition to the total volumes,the volumes of 12 distinct subfields of right and left hippocampi were analysed.Volumes were normalized to total intracranial volumes.Linear regression was used to determine the factors associated with the hippocampal volumes and the hippocampal subfields.Age, gender, education(years),3MS scores,syndromic diagnoses and 25(OH)D levels were used as the independent variables.Funded by TUBITAK 214S048,Hacettepe University THD2018‐17363 and Psychiatric Association of Turkey. Result: 208 patients(54 AD,83 subjective and mild CI,71 cognitively intact)were evaluated.Mean age was 70±9. 58.7% of the sample was female.19.7% had not finished primary school.Mean 25(OH) level was 20.5±12.16 ng/ml,57% of the sample had clinical vitamin D deficiency.25(OH)D levels were not different among diagnostic groups.Cognitive scores and age were the most consistent predictors of hippocampal subfields.In the multivariate analyses there was no association between hippocampal subunits and 25(OH)D levels regardless of the diagnoses(F=0.207, df=2, p=0.813). Conclusion: Hippocampal volumes were not associated with 25(OH)D levels in line with our previous findings.This finding further support the hypothesis that vitamin D might be an independent factor for cognitive impairment.However our results differed from studies reporting positive correlation between hippocampal atrophy and 25(OH)D deficiency.This may be due to the heterogenous and limited nature of our sample,cross‐sectional nature of the study (those with previous vitamin D use were not eliminated) and the limited low range of 25(OH)D levels in our sample,consistent with the Turkish population.Further studies are needed to assess the role of 25(OH)D in neurodegeneration and cognitive decline. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Relationship between 25(OH)D levels and athletic performance in elite Polish judoists.
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Książek, Anna, Dziubek, Wioletta, Pietraszewska, Jadwiga, and Stowinska-Lisowska, Małgorzata
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There is a growing body of evidence for a role of vitamin D in muscle function and for its influence on athletic performance, injury profile and recovery in well-trained athletes. The aim of our study was to assess the relationship between 25(OH)D levels and hand grip strength, lower limb isokinetic strength and muscle power in elite judoists. We enrolled 25 Polish elite judoists. The mean age was 21.9±9.8 years, the mean height was 179.2±6.6 cm, the mean body mass was 79.1 ±8.7 kg, and the mean career duration was 11.5±3.9 years. Serum levels of 25(OH)D and parathormone (PTH) were measured by electrochemiluminescence (ECLIA) using the Elecsys system (Roche, Switzerland). Serum calcium was determined by colorimetry using the Konelab 60 system from bioMérieux (France). Lower limb strength was tested with the Biodex Multi-Joint 4 Isokinetic Dynamometer (Biodex Medical System, New York, USA), and hand grip strength was measured with a manual dynamometer (TAKEI, Japan). Muscle power was determined with the electronic jump mat OptoJump (Microgate, Bolzano, Italy). Our study showed decreased serum 25(OH)D levels in 80% of the professional judoists. The results also demonstrated a statistically significant positive correlation between vitamin D levels and left hand grip strength, muscle power assessed by vertical jump, and total work in left and right knee extensors at an angular velocity of 60°/s. Based on our results it can be concluded that in well-trained professional athletes, there may be a relationship between serum levels of 25(OH)D and skeletal muscle strength, power, and work. [ABSTRACT FROM AUTHOR]
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- 2018
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24. Correlations of 25(OH)D level with blood lipid, inflammatory factors and vascular endothelial function in diabetic patients.
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WANG, J. -M., YE, S. -D., LI, S. -M., and HU, W.
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OBJECTIVE: To investigate the correlation between 25-hydroxyvitamin D [25(OH) D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients. PATIENTS AND METHODS: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. The levels of 25(OH)D in diabetic patients were also compared to detect the levels of serum lipids and inflammatory cytokines in different groups. According to the inflammatory factors, patients with diabetes mellitus were divided into several groups. In addition, 25(OH) D, endothelial function indicators [nitrogen oxide (NO) and von Willebrand factor (vWF)], serum lipids [triglyceride (TG) and total cholesterol (TC)], high-density lipoprotein (HDL), and inflammatory factor tumor necrosis factor-alpha (TNF-α) were compared among different groups. RESULTS: Compared with normal group, the 25(OH)D, NO, and HDL in the diabetic group were significantly lower than those in the normal group (p<0.05). Other lipids and inflammatory factors in the former were significantly higher than those in the normal group. Patients have lower HDL in those with less amount of 25(OH) D. Other blood lipid components such as TC and TG, LDL, and inflammatory factors significantly increased gradually as the 25(OH)D grows (p<0.05). For patients with more inflammatory cytokines, levels of 25(OH)D, NO, vWF, and ET-1 were significantly lower than those with normal inflammatory cytokines. Correlation analysis revealed that 25(OH)D was positively correlated with HDL and NO, but negatively correlated with TG, TC, TNF-α, and vWF. CONCLUSIONS: In diabetic patients, the level of 25(OH)D is decreased and the inflammatory factors are increased. In patients with proper supplementation of 25(OH)D, the inflammation can be reduced and endothelial function can be improved. [ABSTRACT FROM AUTHOR]
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- 2018
25. Lack of correlation between serum 25(OH)D level and endoscopy-based chronic rhinosinusitis in Korean adults.
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Eun Jung Lee, Chi Sang Hwang, and Kyung-Su Kim
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- 2019
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26. Autonomous University of Nuevo Leon Researchers Publish New Data on Diet and Nutrition [An HPLC-UV Method to Assess Human Plasma 25(OH)D [ [3] ]].
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Researchers from the Autonomous University of Nuevo Leon have published a study validating a method to assess vitamin D status. The study aimed to determine the linearity, precision, limits of detection and quantitation, and accuracy of the method. The researchers used an HPLC-UV method with a UV-Vis diode-array detector and an AcclaimTM 120 C18 column. The method showed excellent linearity and reliability in quantifying a vitamin D metabolite in human plasma samples. The study was supported by Universidad Autonoma De Nuevo Leon, the European Regional Development Fund, and Idisba Grants. [Extracted from the article]
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- 2024
27. New Diet and Nutrition Research from Ordos Central Hospital Discussed [Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A...].
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A recent meta-analysis conducted by researchers at Ordos Central Hospital examined the effects of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality in elderly individuals. The study included 14 randomized controlled trials and found that intermittent monthly administration of vitamin D3 significantly raised serum 25(OH)D levels and did not increase all-cause mortality. However, it did not significantly reduce the risks of falls and fractures. The researchers concluded that further research is needed to determine the safety and efficacy of this method. [Extracted from the article]
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- 2024
28. How Much Does Serum 25(OH)D Improve by Vitamin D Supplement and Fortified Food in Children? A Systematic Review and Meta-Analysis
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Nikooyeh, Bahareh, Ghodsi, Delaram, and Neyestani, Tirang R.
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This study was conducted to respond certain important questions regarding the efficacy of vitamin D fortification and supplementation in children using a meta-analytical approach. MEDLINE, PubMed, Embase, Cochrane Library, and Google Scholar were searched, and 2341 studies were found in a preliminary search. After screening of titles and abstracts, 31 studies were selected. Significant raises in circulating 25-hydroxy vitamin D (25(OH)D) concentrations were observed in both groups that took vitamin D supplement (mean difference [MD] 28.7, 95% confidence interval [CI] 22.5–34.9) and vitamin D-fortified foods (MD 20.29, 95% CI 13.3–27.2). The meta-regression revealed a significant association between age of participants (B-1.4, 95% CI -2.8, -0.02, P= 0.047) and dose of vitamin D (B0.007, 95% CI 0.003, 0.01, P< 0.001), with the effect on serum 25(OH)D concentrations. The analysis showed that serum 25(OH)D concentration increases by 0.7 nmol/L for every 100 IU of vitamin D intake after adjustment for age, baseline serum 25(OH)D and latitude which is far less than the reported amount in adults. Altogether, these findings indicate that in a mass vitamin D fortification program, circulating 25(OH)D concentration response in children may be lower in children than in adults and vitamin D supplementation may still be needed in this subpopulation.
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- 2022
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29. The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women.
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ter Horst, K.W., Versteeg, R.I., Gilijamse, P.W., Ackermans, M.T., Heijboer, A.C., Romijn, J.A., la Fleur, S.E., Trinko, R., DiLeone, R.J., and Serlie, M.J.
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Aim Vitamin D deficiency has been proposed to be involved in obesity-induced metabolic disease. However, data on the relationship between 25-hydroxycholecalciferol (25(OH)D) and insulin resistance have been inconsistent, and few studies have investigated the active vitamin D metabolite, 1,25-dihydroxycholecalciferol (1,25(OH) 2 D). This study aimed to determine the relationship between circulating levels of both 25(OH)D and 1,25(OH) 2 D and direct measures of glucose metabolism and insulin action in obese women. Methods Serum levels of 25(OH)D and 1,25(OH) 2 D, and glucose metabolism and tissue-specific insulin action, as assessed in the basal state and during a two-step euglycaemic–hyperinsulinaemic clamp study with [6,6- 2 H 2 ]glucose infusion, were measured in 37 morbidly obese women (age: 43 ± 10 years; body mass index: 44 ± 6 kg/m 2 ). Results Sixteen subjects had circulating 25(OH)D levels < 50 nmol/L, consistent with vitamin D deficiency, and 21 had normal 25(OH)D levels. There were no differences in either baseline characteristics or parameters of glucose metabolism and insulin action between the groups. Serum 25(OH)D, but not 1,25(OH) 2 D, was negatively correlated with both body mass index ( r = −0.42, P = 0.01) and total body fat ( r = −0.46, P < 0.01). Neither 25(OH)D nor 1,25(OH) 2 D levels were related to any measured metabolic parameters, including fasting glucose, fasting insulin, basal endogenous glucose production, and hepatic, adipose-tissue and skeletal muscle insulin sensitivity. Conclusion Obesity was associated with lower levels of circulating 25(OH)D, but not with the hormonally active metabolite 1,25(OH) 2 D. Neither 25(OH)D nor 1,25(OH) 2 D were related to glucose metabolism and tissue-specific insulin sensitivity in obese women, suggesting that vitamin D does not play a major role in obesity-related insulin resistance. [ABSTRACT FROM AUTHOR]
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- 2016
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30. The Effects of Follicular Fluid 25(OH)D Concentration on Intrafollicular Estradiol Level, Oocyte Quality, and Fertilization Rate in Women Who Underwent IVF Program
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Ekapatria, Christofani, Hartanto, Bayuaji, Wiryawan, Permadi, Tono, Djuwantono, Maringan Diapari Lumban, Tobing, Meita, Dhamayanti, Arief, Boediono, and Johanes Cornelius, Mose
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Objective: 25(OH)D (Vitamin D) has been investigated for its role in the process of folliculogenesis and thus affects the quality of oocyte produced by in vitro fertilization. Our aims were to investigate the effects of 25(OH)D levels in follicular fluid, follicular estradiol level, successful fertilization rate in IVF treatment and the correlation between 25(OH)D levels in follicular fluid with the oocyte quality. Design and Setting: This is an analytic observational study with cross-sectional design conducted between September–November 2018 in two fertility clinics at tertiary hospitals in Bandung, Indonesia. Participants: The inclusion criteria were women aged 20–35 years who underwent controlled ovarian stimulation in IVF program with normal ovarian reserve and normal BMI. Eligible women were divided into two groups based on their 25(OH)D levels: low and high. Results: There was a significant difference in oocyte quality (p= 0.03) and follicular estradiol levels (p= 0.02) between the two categories of 25(OH)D levels. High level of 25(OH)D has significantly higher level in comparison with the low level of 25(OH)D. No significant differences were found in terms of successful fertilization rate (p= 0.13). High level of 25(OH)D has higher successful fertilization rate compared to low level of 25(OH)D (71.8% vs 55.26%). A significant positive correlation between 25(OH)D level in follicular fluid and oocyte quality was also found (r= 0.32, p= 0.01). Conclusion: Women with higher level of 25(OH)D are significantly more likely to have high-quality oocyte and follicular estradiol levels than those with low level of 25(OH)D, although there are no significant results for its relation to successful fertilization rate.
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- 2022
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31. Maternal vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) levels associated with blood pressure: A cross-sectional study in Padang, West Sumatra.
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Lipoeto, Nur Indrawaty, Aji, Arif Sabta, Ayudia, Fanny, Faradila, Faradila, and Sukma, Nazla Putri
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- 2018
32. The individual and joint effects of maternal 25(OH)D deficiency and gestational diabetes on infant birth size.
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Liu, Zheng, Meng, Tong, Liu, Jue, Xu, Xiangrong, Luo, Shusheng, Jin, Chuyao, Han, Na, and Wang, Hai-Jun
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Background and Aims: To examine the independent effect of maternal serum 25-hydroxyvitamin D [25(OH)D] deficiency and its joint effect with gestational diabetes mellitus (GDM) on infant birth size.Methods and Results: This retrospective cohort study was conducted in 15,724 mother-offspring dyads in Beijing, China between 2016 and 2017. Outcomes included infant birth weight Z-score (adjusted for gestational age and sex) and large for gestational age (LGA). Exposures were maternal 25(OH)D concentrations. Linear and logistic regression models were used to assess the associations of exposures with continuous and binary outcomes, respectively. Exposure-outcome associations were not observed when analyzing 25(OH)D concentrations continuously or in quartiles (P > 0.05); however, mothers with severely deficient 25(OH)D concentrations (n = 307) had a decreased risk of LGA compared with those with sufficient 25(OH)D concentrations (≥30.0 ng/mL; n = 5400) (adjusted odds ratio (OR): 0.63; 95% confidence interval (CI): 0.42, 0.93). Compared to mothers with no 25(OH)D deficiency (≥20.0 ng/mL) and no GDM (n = 7975), those with both 25(OH)D deficiency and GDM (n = 1090) had 0.15 (95% CI: 0.09, 0.21) higher infant birth weight Z-score and a higher risk of LGA (OR: 1.29; 95% CI: 1.09, 1.52). Maternal 25(OH)D deficiency and GDM had additive interaction on the risk of LGA (relative risk due to interaction: 0.18).Conclusion: Mothers with severely deficient 25(OH)D might have a decreased risk of LGA. However, the joint effect of maternal 25(OH)D deficiency and GDM might increase the risk of LGA. Our findings have clinical and public health implications and provide potential directions for future studies. [ABSTRACT FROM AUTHOR]- Published
- 2020
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33. Variables influyentes en los niveles de 25(OH)D total y libre en población sana
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Fernández-Vicente, M., Miján-de-la-Torre, A., Vella-Ramírez, J.C., Martí-Bonmatí, E., Benito-Ibáñez, V.V., and Martínez-de-Arriba, R.
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La vitamina D ejerce un papel fundamental en la homeostasis del calcio y el metabolismo óseo. Procede, mayoritariamente, de la síntesis cutánea, por acción de la luz solar. Así, variaciones en la exposición a esta radiación modifican sus niveles séricos. Estudiamos dos analitos diferentes de vitamina D en población sana española, y la influencia de la estacionalidad, el clima y la latitud en sus estatus.
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- 2022
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34. Intra-trial Mean 25(OH)D and PTH Levels and Risk of Falling in Older Men and Women in the Boston STOP IT Trial
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Dawson-Hughes, Bess, Wang, Jifan, Barger, Kathryn, Bischoff-Ferrari, Heike A, Sempos, Christopher T, Durazo-Arvizu, Ramon A, and Ceglia, Lisa
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- 2022
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35. Association between serum 25 (OH) D levels and depression symptoms in adults with prediabetes.
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Vu, Thi Quynh Chi, Tran, Quoc Kham, and Niu, Kaijun
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Depression symptoms are a significant risk factor for prediabetes-related diabetes, and low vitamin D levels are connected with depression symptoms. The goal of this study is to examine the association between vitamin D and depression symptoms in prediabetic persons. This cross-sectional survey was conducted in Tianjin, China, among 4051 individuals. Symptoms of depression were assessed using the Self-Rating Depression Scale (SDS) (cut-off point SDS ≥45). Serum 25 (OH) D concentrations were determined using an enzyme immunoassay (OCTEIA 25-hydroxy Vitamin D, IDS Ltd, UK) and classified into three levels: 50 nmol/L, 50–75 nmol/L, and >75 nmol/L. The link between serum 25 (OH) D concentrations and depression symptoms in prediabetes was investigated using multiple logistic regression analysis. The models were adjusted for a variety of potential confounders. The prevalence of symptoms of depression in prediabetic adults was 14.2% (12.5% males and 16.4% females). After adjusting for potentially confounding variables, the odds ratios - ORs for symptoms of depression in women across serum 25 (OH) D levels were 1.00 (reference), 1.03 (0.57, 1.39), and 0.28 (0.12, 0.57), respectively (p = 0.0015). However, no statistically significant connection was discovered in males. In women with prediabetes, we showed a substantial negative connection between serum 25 (OH) D levels and depressed symptoms. Vitamin D supplementation may be an effective way to decrease the risk of depression symptoms in women with prediabetes. • We investigated 25 (OH) D concentrations and depression symptoms in 4051 women with prediabetes. • We showed a substantial negative connection between serum 25(OH)D levels and symptoms of depression. [ABSTRACT FROM AUTHOR]
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- 2022
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36. Relationship between 25(OH)D levels and circulating lipids in African American adolescents.
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Sriram, Swetha, Croghan, Ivana, Lteif, Aida, Donelan-Dunlap, Bonnie, Zhuo Li, and Kumar, Seema
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Background: Vitamin D deficiency is commonly seen among African American adolescents. Lipid levels during childhood are excellent predictors of adult dyslipidemia and atherosclerosis. There is a paucity of data on the relationship between 25 hydroxy vitamin D [25(OH)D] levels and lipids among African American adolescents. The objective of this study was to determine if there is an association between 25(OH)D levels and circulating lipids in African American adolescents residing in midwestern United States. Methods: African American adolescents residing in Rochester, MN (latitude 44°N), USA, underwent measurements of 25(OH)D and lipids following overnight fast. Pearson's correlation test, linear regression model and scatter plots were used to explore the association between 25(OH)D levels and lipids. Results: 25(OH)D levels <30 ng/mL were seen in 21/24 (87%) of the subjects. 25(OH)D levels were inversely correlated with total cholesterol (r = -0.42; p = 0.040) and with non-high-density lipoprotein (non-HDL) cholesterol (r = -0.42; p = 0.040). These associations remained statistically significant after adjustment for age, gender and adiposity. In the multivariate linear regression model, and after adjusting for BMI Z-score, each 1 ng/mL increase in 25(OH)D was associated with a decrease in total cholesterol of 1.38 mg/dL (95% CI: -2.63, -0.14, p = 0.030) and with a decrease in non-HDL cholesterol of 1.14 mg/dL (95% CI: -2.09, -0.18, p = 0.020). Conclusions: 25(OH)D levels were inversely correlated with total cholesterol and non-HDL cholesterol levels in African American adolescents residing in midwestern United States. Further studies with larger sample sizes are needed to determine if low vitamin D status in African American adolescents is a potential modifiable risk factor for cardiovascular disease. [ABSTRACT FROM AUTHOR]
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- 2016
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37. Assessment of plasma level of 25(OH)D and its correlation with cardiorespiratory fitness in young females of Dammam City, KSA.
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Al Asoom, Lubna I.
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Copyright of Journal of Taibah University Medical Sciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
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38. Increases in pre-hospitalization serum 25(OH)D concentrations are associated with improved 30-day mortality after hospital admission: A cohort study.
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Amrein, Karin, Litonjua, Augusto A., Moromizato, Takuhiro, Quraishi, Sadeq A., Gibbons, Fiona K., Pieber, Thomas R., Jr.Camargo, Carlos A., Giovannucci, Edward, and Christopher, Kenneth B.
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Summary Context Pre-hospital vitamin D status may be a modifiable risk factor for all-cause mortality among hospitalized patients. Objective To examine the association between increases in serum 25-hydroxyvitamin D [25(OH)D] levels during the year before hospitalization and risk of 30-day all-cause mortality after hospital admission. Design Retrospective cohort study. Setting Two Boston teaching hospitals. Patients or other participants We studied 4344 adults hospitalized between 1993 and 2011 who had serum 25(OH)D concentrations measured at least twice within 7–365 days before the index hospitalization. Intervention(s) None. Main outcome measure(s) The exposure of interest was change in pre-hospital serum 25(OH)D concentrations. The main outcome was 30-day all-cause mortality. We used mixed-effects logistic regression to describe how 30-day mortality differed with changes in pre-hospital 25(OH)D concentrations. Additionally, the odds of 30-day mortality in patients with pre-hospital 25(OH)D increases of ≥10 ng/mL was compared to that of patients with increases of <10 ng/mL. Results In a mixed-effect logistic regression model adjusted for age, gender, race, type (medical/surgical), Deyo-Charlson Index, creatinine and hematocrit, 30-day all-cause mortality rate was 8% (95%CI: 1–15) lower for each 10 ng/mL increase in pre-hospital 25(OH)D ( P = 0.025) compared with the 30-day all-cause mortality rate in the entire cohort. In an adjusted logistic regression model, absolute changes of ≥10 ng/mL in patients with initial 25(OH)D concentrations < 20 ng/mL (n = 1944) decreased the odds of 30-day all-cause mortality by 48% (adjusted OR 0.52; 95%CI 0.30–0.93; P = 0.026) compared to patients with changes of <10 ng/mL. Conclusions In patients with initial 25(OH)D < 20 ng/mL, subsequent improvements in vitamin D status before hospitalization are associated with decreased odds of 30-day all-cause mortality after hospital admission. A causal relation may not be inferred from this observational study. [ABSTRACT FROM AUTHOR]
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- 2016
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39. Vitamin D [25(OH)D] and 1,25(OH)2D serum concentrations in patients tested at the Charlotte Maxeke Johannesburg Academic Hospital
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Botha, S, Maphayi, MR, Cassim, N, and George, JA
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Introduction:There has been a significant increase in vitamin D [25(OH)D] testing in recent years.Aims:To describe the number of tests, concentrations for 25(OH)D and 1,25(OH)2D in adults (≥ 18 years), characteristics of those tested and to determine the 25(OH)D concentration at which parathyroid hormone increases (PTH threshold).Methods:Data were extracted for 25(OH)D and 1,25(OH)2D tests, from the National Health Laboratory Services data warehouse for Charlotte Maxeke Johannesburg Academic Hospital from 2015 to 2017. Results were categorised by age, sex and race. Vitamin D status was described using National Academy of Medicine guidelines. The PTH threshold was determined by LOWESS plots.Results:25(OH)D and 1,25(OH)2D tests increased, with no change in median concentrations over time. Black Africans (6.7%) had the highest prevalence of Vitamin D deficiency (VDD). Males had significantly lower 25(OH)D values (p < 0.001) and a higher proportion of VDD (p = 0.009). Younger patients (< 30 years; 7.9%) and elderly (> 74 years; 10.5%) black Africans had highest prevalence of VDD. The PTH threshold differed by race group.Conclusions:Clear testing guidelines are needed to curb test overutilisation. Further work is required to understand the appropriate cut-off levels to define VDD in our populations.
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- 2021
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40. How Much Does Serum 25(OH)D Improve by Vitamin D Supplement and Fortified Food in Children? A Systematic Review and Meta-Analysis
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Nikooyeh, Bahareh, Ghodsi, Delaram, and Neyestani, Tirang R.
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- 2022
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41. Genetically Predicted Lifelong Circulating 25(OH)D Levels are Associated With Serum Calcium Levels and Kidney Stone Risk
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Jian, Zhongyu, Huang, Yu, He, Yazhou, Jin, Xi, Li, Hong, Li, Sheyu, and Wang, Kunjie
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- 2022
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42. Reports on Heart Disease Findings from Huazhong University of Science and Technology Provide New Insights [Associations of Serum 25(Oh)D With Risk of Recurrent Cardiovascular Events In Individuals With Coronary Heart Disease].
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A report from Huazhong University of Science and Technology in Wuhan, China discusses the relationship between vitamin D and the risk of recurrent cardiovascular events in individuals with coronary heart disease (CHD). The study found that higher serum 25-hydroxyvitamin D (25(OH)D) concentrations were associated with a lower risk of recurrent cardiovascular events, with a potential threshold around 50 nmol/L. The findings suggest the importance of maintaining adequate vitamin D levels in preventing recurrent cardiovascular events in individuals with CHD. The research was funded by the National Natural Science Foundation of China and other organizations. [Extracted from the article]
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- 2024
43. Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study.
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Ibero-Baraibar, Idoia, Navas-Carretero, Santiago, Abete, Itziar, Martinez, J.A., and Zulet, M.A.
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Summary Background & aims The aim of this study is to further clarify the role of plasma 25(OH)D concentration after a weight-lowering nutritional intervention on body composition, blood pressure and inflammatory biomarkers in overweight/obese middle-aged subjects. Methods This longitudinal research encompassed a total of 50 subjects [57.26 (5.24) year], who were under a 15% energy restricted diet for 4 weeks. Anthropometric and body composition variables, blood routine, inflammatory markers as well as 25(OH)D were analysed. Results Circulating 25(OH)D levels [12.13(±17.61%)] increased while anthropometric, body composition, routine blood markers as well as the concentration of TNF-α, C-reactive protein and Lp-PLA2 were significantly reduced after the intervention. Multiple linear regression analyses evidenced that Δ25(OH)D increase was linked to the decrease in weight, adiposity, SBP and IL-6 levels. Moreover, a relationship was found between Δ25(OH)D, Δfat mass ( r = −0.405; p = 0.007), ΔSBP ( r = −0.355; p = 0.021) and ΔIL-6 ( r = −0.386; p = 0.014). On the other hand, a higher increase in 25(OH)D was accompanied by reductions in weight, BMI, SBP, IL-6 and an increase in bone mineral concentration ( p < 0.05). Interestingly, higher levels of 25(OH)D at the endpoint, showed a significantly higher decrease in weight, BMI and total fat mass. Conclusions The increase in plasma 25(OH)D level is linked with the decrease in SBP and adiposity in middle-aged subjects after a weight-loss intervention. Therefore, 25(OH)D assessment is a potential marker to be accounted in metabolic measures related to blood pressure, adiposity and inflammation in obesity management. Trial registration www.clinicaltrials.gov (NCT01596309). [ABSTRACT FROM AUTHOR]
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- 2015
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44. Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study.
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Yalbuzdag, Seniz Akcay, Sarifakioglu, Banu, Afsar, Sevgi Ikbali, Celik, Canan, Can, Aslı, Yegin, Tugba, Senturk, Burcu, and Guzelant, Aliye Yildirim
- Abstract
Background In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment. Methods The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status. Results A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients. Conclusions High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients. [ABSTRACT FROM AUTHOR]
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- 2015
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45. Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study.
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Torbergsen, Anne C., Watne, Leiv O., Wyller, Torgeir B., Frihagen, Frede, Strømsøe, Knut, Bøhmer, Thomas, and Mowe, Morten
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Summary Background & aims The incidence of hip fractures in Oslo is among the highest in the world. Vitamin D, as well as vitamin K, may play an important role in bone metabolism. We examined if vitamin K1 and 25(OH)D were associated with an increased risk of hip fracture, and whether the possible synergistic effect of these two micronutrients is mediated through bone turnover markers. Methods Blood was drawn for vitamin K1, 25(OH)D, and the bone turnover marker osteocalcin upon admission for hip fracture and in healthy controls. Results Vitamin K1 and 25(OH)D were independently associated with a risk of hip fracture. The adjusted odds ratio (95% CI) per ng/ml increase in vitamin K1 was 0.07 (0.02–0.32), and that per nmol/L increase in 25(OH)D was 0.96 (0.95–0.98). There was a significant interaction between 25(OH)D and vitamin K1 ( p < 0.001), and a significant correlation between total osteocalcin and vitamin K1 and 25(OH)D (rho = 0.18, p = 0.01; rho = 0.20, p = 0.01, respectively). Conclusions Vitamin K1 and 25(OH)D are lower in hip fracture patients compared with controls. Vitamin K1 and 25(OH)D are independently and synergistically associated with the risk of hip fracture when adjusting for confounders. Intervention studies should include both vitamins. [ABSTRACT FROM AUTHOR]
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- 2015
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46. Interlaboratory Trial for Measurement of Vitamin D and 25-Hydroxyvitamin D [25(OH)D] in Foods and a Dietary Supplement Using Liquid Chromatography-Mass Spectrometry.
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Roseland, Janet Maxwell, Patterson, Kristine Y., Andrews, Karen W., Phillips, Katherine M., Phillips, Melissa M., Pehrsson, Pamela R., Dufresne, Guy L., Jakobsen, Jette, Gusev, Pavel A., Savarala, Sushma, Nguyen, Quynhanh V., Makowski, Andrew J., Scheuerell, Chad R., Larouche, Guillaume P., Wise, Stephen A., Harnly, James M., Williams, Juhi R., Betz, Joseph M., and Taylor, Christine L.
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- 2016
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47. Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?
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Henriksen, Vanessa T., Rogers, Victoria E., Rasmussen, G. Lynn, Trawick, Roy H., Momberger, Nathan G., Aguirre, Dale, and Barker, Tyler
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CYTOKINES ,INFLAMMATION ,BLOOD serum analysis ,ARTHROPLASTY ,KNEE surgery ,VITAMIN D ,SKELETAL muscle - Abstract
Abstract: Vitamin D is a fat-soluble micronutrient that regulates inflammation and skeletal muscle size and function. Inflammation and skeletal muscle dysfunction (i.e., atrophy and weakness) are predominant impairments that continue to challenge the rehabilitation from total knee arthroplasty (TKA). Data suggest a decrease in serum 25-hydroxyvitamin D (25(OH)D) concentrations after TKA. Despite the decrease being attributed to a systemic inflammatory response, it is unclear what inflammatory mediator(s) is contributing to the decrease in serum 25(OH)D concentrations after TKA. In immune cells, pro-inflammatory cytokines mediate the enzymatic conversion of 25(OH)D to 1,25-dihydroxyvitamin D, implying that pro-inflammatory cytokines contribute to the decrease in substrate availability (i.e., 25(OH)D). We propose the hypothesis that pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after TKA. To complement the supporting literature for the proposed hypothesis, we analyzed serum 25(OH)D and pro-inflammatory cytokine concentrations prior to and serially after TKA in a case subject (female; age, 62year; height, 160cm; body mass, 63kg; body mass index, 26.5kg/m
2 ). The subtle decrease (12%) from pre-surgery to 2-d post-surgery and the more pronounced decrease (74%) from 3-week to 8-week post-surgery in serum 25(OH)D concentrations corresponded with the increase in serum pro-inflammatory cytokine (i.e., TNF-α, IFN-γ, IL-1β, GM-CSF, and IL-6) concentrations. This observation lends credence to the proposed hypothesis that pro-inflammatory cytokines could contribute to the decrease in serum 25(OH)D concentrations after TKA. Clearly, future research is needed to confirm the proposed hypothesis and to identify if attenuating the decrease in serum 25(OH)D concentrations improves patient outcomes after TKA. [Copyright &y& Elsevier]- Published
- 2014
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48. Blunted serum 25(OH)D response to vitamin D3supplementation in children with autism
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Kerley, Conor P., Elnazir, Basil, Greally, Peter, and Coghlan, David
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Introduction:Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation.Methods:We conducted post-hoc analysis of two double-blind, randomized, placebo-controlled trials (RCT) of vitamin D3supplementation, one RCT involving children with ASD and another involving children with asthma. Both trials were conducted in the same geographic location (Dublin, Ireland, 53°N), conducted over Winter season and utilized the same vitamin D3dose (2000 IU/day).Results:We included 18 children with ASD and 17 children with asthma. There was no significant difference in 25(OH)D or age at baseline, however, BMI was significantly lower in ASD (P= 0.03). Compliance with vitamin D supplementation was high in both trials. Despite a significantly longer intervention period (20w vs. 15w; P < 0.0001), ASD children had a significantly lower absolute increase (+26 vs. +45 nmol/l) in 25(OH)D (P = 0.04).Conclusions:Despite similar demographics, children with ASD had a lower increase in 25(OH)D levels with supplementation. Potential mechanisms include altered absorption/metabolism as well as well genetic factors. Clinical and research work relating to vitamin D is ASD should measure 25(OHO)D response to supplementation to assess therapeutic doses.
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- 2020
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49. Researchers from Medical University of South Carolina Report on Findings in Gestational Diabetes [Predicting Comorbidities of Pregnancy: a Comparison Between Total and Free 25(Oh)D and Their Associations With Parathyroid Hormone].
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A study conducted by researchers from the Medical University of South Carolina explores the relationship between vitamin D levels and pregnancy complications, specifically gestational diabetes. The study suggests that free 25(OH)D concentration, a measure of vitamin D status, may be a better indicator of pregnancy complications than total 25(OH)D concentration. The researchers found a significant relationship between lower mean free 25(OH)D concentration and the development of gestational diabetes. However, further research with a larger cohort is needed to validate these findings and explore the relationship with other pregnancy complications. [Extracted from the article]
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- 2024
50. Oral Vitamin D Supplementation to Mothers During Lactation— Effect of 25(OH)D Concentration on Exclusively Breastfed Infants at 6 Months of Age: A Randomized Double-Blind Placebo-Controlled Trial
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Trivedi, Maharshi, Faridi, Mohammad Moonis Akbar, Aggarwal, Anju, Madhu, Sri Venkata, and Malhotra, Rajiv Kumar
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Background:Exclusively breastfed infants are at risk of vitamin D deficiency.Objective:To find out proportion of exclusively breastfed infants having serum 25(OH)D concentration <11 ng/mL at 6 months of age with or without oral supplementation of vitamin D3to lactating mothers.Methods:Randomized placebo-controlled study included 132 mothers and infants divided into two groups. Mothers received either vitamin D360,000 IU between 24 and 48 hours postpartum and at 6, 10, and 14 weeks amounting to 240,000 IU of vitamin D3or placebo. Serum 25(OH)D concentration in the mothers was measured at recruitment and that of infants, at birth and 6 months. Infants were evaluated for rickets at 6 months.Findings:Total 114 mother–infant dyads followed. Subjects in both groups were comparable in basic characteristics. At 6 months of age, serum 25(OH)D concentration in infants was 18.93 (5.12) ng/mL in the intervention group and 6.43 (3.76) ng/mL in the control group (mean difference = 12.5; 95% CI = 10.80–14.17; p< 0.001) and vitamin D deficiency and insufficiency was corrected in 93.1% and 38% infants, respectively, in the intervention group. There was no change in the vitamin D status of infants in the control group. In 60.3% infants (RR = 0.519; 95% CI = −0.485 to 0.735) of the intervention group 25(OH)D concentration was <20 ng/mL at 6 months of age. Six infants in the control group suffered from biochemical rickets. Radiological rickets developed in one infant in the intervention group and two infants in the control group.Conclusion:Serum 25(OH)D concentration of exclusively breastfed infants rise significantly when mothers are orally supplemented with 240,000 IU of vitamin D3during lactation in comparison with the infants of unsupplemented mothers with 94.6% and 48.1% reduction in the risk of vitamin D deficiency and insufficiency, respectively, at 6 months of age.
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- 2024
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