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This study aimed to describe health-related quality of life (HRQoL) 3 months and 1 year after stroke, compare HRQoL between dependent (modified Rankin scale [mRS] 3-5) and independent (mRS 0-2) patients, and identify factors predictive of poor HRQoL. Patients with a first ischemic stroke or intraparenchymal hemorrhage from the Joinville Stroke Registry were analyzed retrospectively. Using the 5-level version of the EuroQol-5D questionnaire, HRQoL was calculated for all patients 3 months and 1 year after stroke, stratified by mRS score (0-2 or 3-5). One-year HRQoL predictors were examined using univariate and multivariate analyses. Three months after a stroke, data from 884 patients were analyzed; 72.8% were categorized as mRS 0-2 and 27.2% as mRS 3-5, and the mean HRQoL was 0.670 ± 0.256. At 1-year follow-up, 705 patients were evaluated; 75% were classified as mRS 0-2 and 25% as mRS 3-5, and the mean HRQoL was 0.71 ± 0.249. An increase in HRQoL was observed between 3 months and 1 year (mean difference 0.024, P <.0001), both in patients with 3-month mRS 0-2 (0.013, P =.027) and mRS 3-5 (0.052, P <.0001). Increasing age, female sex, hypertension, diabetes, and a high mRS were associated with poor HRQoL at 1 year. This study described the HRQoL after a stroke in a Brazilian population. This analysis shows that the mRS was highly associated with HRQoL after stroke. Age, sex, diabetes, and hypertension were also associated with HRQoL, although not independently of mRS. • Health-related quality of life (HRQoL) utility after stroke is currently unknown in Brazil. Using population-based data, we found that the 1-year HRQoL after stroke is 0.71, significantly lower in dependent (0.40) than independent patients (0.81). • These real-world findings are helpful for many future studies, such as those examining the burden of stroke and economic evaluations that include stroke as an outcome or seek to improve functional status after stroke. • The study also confirms that the modified Rankin scale (mRS) is a reliable HRQoL surrogate and provides mapping scores to convert mRS to utility, which is helpful for stroke studies that include the mRS but not the EQ-5D. [ABSTRACT FROM AUTHOR]

Nowadays, there is a growing need for rehabilitation associated with demographic changes and health trends, with an increase in the prevalence of non-communicable diseases and an aging population. Although well-being is classically associated with a set of physical activities, the reality of today's society often shows that there is a lack of time available to develop activities that promote well-being. This fact is aggravated in aging populations by less mobility and greater isolation. In this domain, information and communication technologies have greatly contributed to helping healthcare providers to develop new understanding, measurement and action strategies that promote the physical and emotional well-being of their patients. Accordingly, the role of Virtual Reality has been shown to be promising for the generation of well-being. This article, as part of a broader funding project, reviews the state of the art of the role that Virtual Reality has played in the promotion of well-being, being an exercise of conceptualization that converges in the proposal of a conceptual model - an Index-Engine of Physical and Emotional Sustainability, which will be prototyped and field tested in the future. [ABSTRACT FROM AUTHOR]

Introduction: Studies on the normal electrocardiogram limits in African populations are limited, especially in sub-Saharan Africa. There is no literature describing normal ECG limits in Angolans.Objectives: The aim of this study is to establish the normal ECG limits for adult Angolans, without established heart disease, stratified by gender and age.Methods: A cross-sectional study was performed, involving 2179 participants from a population in northern Angola, without established heart disease, aged between 15 and 74 years. A 12‑lead ECG and a rhythm strip were recorded for all participants and analysed and processed by the University of Glasgow software and encoded by the Minnesota Code. The normal range of the electrocardiographic parameters were established as the 2nd and 98th percentiles of the measurement distribution per age group and gender. Mann-Whitney and Kruskal-Wallis tests were used for two independent groups and Bonferroni adjustments were used for multiple testing. GAMLSS models were used to obtain the continuous age-dependent percentile curves.Results: The normal range of the ECG differed between men and women: heart rate 49 to 100 bpm vs. 55 to 108 bpm, P wave duration 81 to 130 ms vs. 84 to 130 ms, PR interval 119 to 210 ms vs. 120 to 202 ms, QRS duration 74 to 110 ms vs. 70 to 104 ms, QT interval 324 to 441 ms vs. 314 and 438 ms, P-wave axis - 29 to 850 vs. -18 to 810, QRS-wave axis - 13 to 850 vs. -180 and 820, T-wave axis 0 to 720 vs. -8 to 730, Sokolow-Lyon index 2.13 to 6.21 mV vs. 1.60 to 4.87 mV, Cornell index 0.17 to 6.24 mV vs. 0.14 mV to 4.35 mV.Conclusions: The values described for the electrocardiographic measurements above can act as a reference framework for Angolan adults without established heart disease. Our study suggests that the normal range of most ECG parameters vary according to age and sex and the ECG diagnostic criteria must therefore be specific for these demographic measures. [ABSTRACT FROM AUTHOR]

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Photocatalysis was recognised as a suitable process for the photoabatement of atmospheric pollutants. The photooxidation mechanism on TiO 2 has been widely studied. However, recent studies demonstrated that the very often-assumed photooxidation intermediated by the hydroxyl radical cannot explain all the experimental observations. Indeed, this study contributes for a new understanding of NO photooxidation. First, the adsorption equilibrium isotherms of NO, NO 2 and H 2 O on the photocatalyst, Aeroxide ® P25 from Evonik Industries, were obtained. Also, the concentration of hydroxyl radicals was determined by photoluminescence. A comprehensive design of experiments was then followed; NO conversion and selectivity were obtained as a function of the relative humidity, irradiance, NO inlet concentration and residence time, following a response surface methodology (RSM). These results were then used to discuss the photooxidation mechanism of NO. [ABSTRACT FROM AUTHOR]

The present study evaluated whether a natural dietary additive, dried Artemisia annua leaves, may be useful to control Rhipicephalus (Boophilus) microplus on naturally infested cattle. Twenty heifers of the Canchim breed, weighing around 250 kg, were divided into two equally sized experimental groups: 1) control animals and 2) animals receiving 200 g/day of dried A. annua leaves for two months. Before treatment began, the animals were homogeneously distributed in control and treatment groups based on their pre-treatment weight and tick infestation level. Counts of engorged female ticks then occurred weekly during the two-month experimental period. We also monitored cattle weight gain and packed cell volume (PCV). Artemisinin (0.96%) was quantified in the plant material by high-performance liquid chromatography with refractive index detector (HPLC-IR). No statistical differences between the control and treatment groups were observed for engorged female counts (log averages of 1.3 ticks and 1.4 ticks per animal, respectively), daily cattle weight gain (0.910 kg and 0.888 kg, respectively) or PCV (33.5% and 33.0%, respectively). We conclude that the oral supplementation of cattle feed with dried A. annuna leaves did not control natural infestation of R. (B.) microplus . The hypothesis of artemisinin’s action on cattle ticks by ingestion through the animals’ blood was not confirmed at the evaluated dose. [ABSTRACT FROM AUTHOR]

This paper describes a method specially devoted to quantitatively measure the success of collaborative university-industry R&D funded contracts, which could be managed as a singular project or a program of projects. The method aims to measure the success throughout the program/project lifecycle, combining both retrospective (lagging) and prospective (leading) performance indicators. The method uses tangible/specific outcomes as performance indicators, like patents or publications, as well as intangible/subjective performance indicators such as social relationships, organizational arrangements or motivations. The proposed method was conceived by conducting a thorough review of the published literature on this area, and by analyzing, as case studies, two consecutive R&D collaborative funded programs, between University of Minho and Bosch Car Mutimedia, amounting to an overall investment of over 70 million Euros, from 2012 to 2018. [ABSTRACT FROM AUTHOR]

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In this article we analyze the evolution of the attitudes towards Europe of Portuguese parliamentary elites in the context of the sovereign debt crisis. Our analysis relies on interviews to a total of 227 MPs in the context of the ENEC project in 2014 and of the Intune Project in 2009 and 2007. Our principal finding is that an important gap has risen between the attitudes of the MPs and of the masses. Indeed, while the Portuguese are becoming increasingly less pro- European, this is not the case of their deputies. We show that, in 2014, the percentage of deputies that believed that EU membership benefited the country has decreased a little, but it stays as high as 89%. Our data, however, show that MPs now exhibit lower levels of trust towards the European institutions. Interestingly, the drop in the levels of trust towards EU institutions does not affect all institutions equally: trust towards the European Parliament remains constant regarding 2007, whereas the levels of trust in the remaining two institutions decrease. Finally, we show that it is in the Socialist Party (PS) that there is the steepest decline in the level of overall trust, which is rooted in declining levels of confidence in the European Commission. Given that PS has traditionally portrayed itself as the most pro-Europe of the Portuguese parties, this is solid evidence of a growing discontent with the European Commission. [ABSTRACT FROM AUTHOR]

Copyright of Relações Internacionais is the property of Relacoes Internacionais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The stagnation temperatures experienced by glazed photovoltaic-thermal (PV-T) collectors pose a threat to their performance and longevity, in part due to the limited temperature stability of ethylene vinyl acetate (EVA) encapsulants. In order to identify suitable solutions for application in residential solar domestic hot water (SDHW) PV-T systems, a comparative analysis of known overheating prevention and stagnation handling measures was conducted and dynamic simulations were used to support the analysis. While no measure was found to comply with all desirable goals including reliability, implementation and operation costs, integral venting mechanisms were identified as the most promising among the control systems reviewed. Moreover, active collector heat dumping and automatic collector shading led to minimal electrical efficiency increases and decreases, respectively, while purging tank water when the collector overheats was found to be ineffective due to delays in the start of circulation. [ABSTRACT FROM AUTHOR]

Purpose Hemorrhagic cystitis is an important dose limiting side effect of ifosfamide based cancer chemotherapy. Despite chemoprophylaxis inflammation can still be found in cystoscopy guided biopsies. Previous studies confirmed the role of TNF-α and IL-1β. We evaluated the protective effect of the IL-1R antagonist anakinra and the anti-TNF-α antibody infliximab in experimental ifosfamide induced hemorrhagic cystitis. Materials and Methods Hemorrhagic cystitis was induced by an injection of ifosfamide (400 mg/kg intraperitoneally) in Swiss wild-type C57Bl/6, IL-1R –/– , TNFR1 –/– or TNFR1/R2 –/– mice. Mice were treated 30 minutes before ifosfamide with anakinra (100 mg/kg intraperitoneally), infliximab (5 mg/kg intraperitoneally) or vehicle. Visceral nociception was evaluated after hemorrhagic cystitis induction. At 12 hours the animals were sacrificed. Bladders were harvested to assess bladder wet weight, vascular permeability, macroscopic and microscopic findings, muscle contractility, and for cystometrography. Inflammatory cell infiltration was assessed by myeloperoxidase assay and flow cytometry. Results Anakinra attenuated hemorrhage, edema, neutrophil infiltration, visceral hyperalgesia and bladder dysfunction. IL-1R –/– mice also showed milder hemorrhagic cystitis. Infliximab inhibited bladder edema and visceral hyperalgesia without preventing hemorrhage, bladder dysfunction, neutrophils or accumulation. Additionally, the lack of TNFR1 decreased bladder edema but not cell infiltration whereas concomitant deficiency of TNFR1 and TNFR2 resulted in worse hemorrhagic cystitis. Conclusions Anakinra is effective for preventing experimentally ifosfamide induced hemorrhagic cystitis. It seems that neutrophil and macrophage infiltration in this circumstance depends on IL-1 signaling through IL1R. Possibly TNFR2 has a protective role in hemorrhagic cystitis. [ABSTRACT FROM AUTHOR]

Objective: To assess the level of knowledge of primary school teachers in the public school network of Northeastern Brazil with respect to management of dental trauma and its relationship with prognosis. Methods: A questionnaire was applied to 195 school teachers of public schools in Northeastern Brazil. The questionnaire comprised 12 objective questions about dental trauma and methods for its prevention and management. Data were submitted to chi-square test and Poisson regression test (P > 0.05). Results: Out of the 141 teachers who responded the questionnaires, the majority were women (70.2%) and most of them had experienced previous dental accidents involving a child (53.2%). The majority (84.4%) had incomplete college education and few were given some training on how to deal with emergency situations during their undergraduate course (13.5%) or after it (38.3%). Their level of knowledge about dental trauma and emergency protocols showed that unsatisfactory knowledge level was associated with the male sex: 46% higher for men in comparison to women (P = 0.025). Conclusions: Approximately half of teachers evaluated had unsatisfactory knowledge about dental trauma and emergency protocols, with female teachers showing more knowledge than men. [ABSTRACT FROM AUTHOR]

Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Relações Internacionais is the property of Relacoes Internacionais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: Background/purpose: The mechanism of fetal gastric dilation in gastroschisis is controversial. This study was designed to characterize changes in the contractile profile of strips of stomach from rats following experimental gastroschisis. Methods: Pregnant Wistar rats were operated on day 18.5. Fetuses were divided into three groups: gastroschisis (G), sham (S), and control (C). On day 21.5, gastric fundus and antrum strips were obtained and suspended to a force transducer connected to a digital data acquisition system. They were submitted to increasing concentrations of carbachol (CCh) and weighed at the end of each procedure. Frequency and amplitude of each contraction were evaluated. Results: Under basal conditions, spontaneous oscillatory contractions of antrum and fundus strips of G, S, and C were similar (P>0.05; ANOVA). However, cumulative concentrations of CCh (0.01–100μM) produced different effects in all groups and were characterized by a significant increase in amplitude and frequency of spontaneous contractions in antral smooth muscle and a sustained increase in tonus in fundic strips. Upon analysis, no significant difference in frequency or amplitude was noted in antral tissues comparing C to G and to S (P>0.05). No significant contractility difference was noted in fundic smooth muscle (comparing all groups, P >0.05), with the CCh-induced curve following a typical sigmoidal format, dependent on increasing concentrations (P<0.001). Conclusions: Gastric contractile responses to CCh are preserved in experimental gastroschisis. These results do not support the theory that gastric dilation occurs secondary to intestinal inflammation alone. [Copyright &y& Elsevier]

Abstract: Objective: Many studies have documented the high rates of functional impairment among patients with schizophrenia. The majority of the available instruments used to assess functioning, however, focus on global measures of functional recovery rather than specific domains of psychosocial functioning. Most of these instruments have important limitations regarding use in psychiatry. The aim of the present study was to evaluate the psychometric properties of the Brazilian version of the Functioning Assessment Short Test (FAST) in patients with schizophrenia. Methods: A convenience sample of 107 chronic outpatients with schizophrenia and 108 controls was assessed in a university hospital (Hospital de Clínicas de Porto Alegre, Brazil). Psychometric properties of FAST (internal consistency, concurrent validity, and test-retest reliability) were analyzed. Results: The internal consistency obtained was high; the Cronbach’s alpha was 0.89. FAST total score was higher in patients than in the control group (Z = 11.95; P<0.001). FAST test-retest agreement was excellent (intraclass correlation coefficient = 0.93; 95% confidence interval 0.81–0.97). In addition, FAST displayed a positive correlation with the Brief Psychiatric Rating Scale (ρ = 0.41; P<0.001) and a negative correlation with the Global Assessment of Functioning scale (ρ =−0.71; P = 0.001). Conclusions: Psychotic symptoms, comorbidity, and functional and cognitive impairment contribute to the decreased quality of life of patients with schizophrenia. It is important to obtain a valid and reliable instrument that is capable of evaluating the functional domains in this pathology. In this context, FAST showed accurate psychometrics properties and was able to detect functional differences between patients with the diagnosis of schizophrenia and healthy subjects. [Copyright &y& Elsevier]

Abstract: Background: The use of crack cocaine is a major public health concern in Brazil and internationally. Recent data suggest that childhood trauma is associated with worse outcomes among cocaine users. This study had the objective of evaluating the relationship of childhood trauma with executive functioning and impulsivity in outpatients with crack cocaine use disorders. Methods: This is a cross-sectional study of 84 consecutive outpatients with a primary crack cocaine use disorder who sought treatment in Porto Alegre, Brazil. Childhood trauma was evaluated with the Childhood Trauma Questionnaire; executive functioning, with the Wisconsin Card Sorting Test; and impulsivity, with the Barratt Impulsivity Scale. Results: Childhood trauma was strongly associated with executive dysfunction and impulsivity, even when controlled for possible confounders. Conclusions: Childhood trauma may be associated with executive dysfunction and impulsivity in crack cocaine users. The full impact of trauma needs to be further investigated in longitudinal studies. [Copyright &y& Elsevier]