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Hyperbaric oxygen therapy (HBOT) is utilized as an adjunctive treatment for human and veterinary patients with compromised tissues. Medical records from two veterinary hospitals with HBOT chambers were searched for small animal veterinary dentistry and oral surgery specialty patients. The HBOT records were combined with the medical records from the referring specialty veterinary dentistry and oral surgery services. Clinical indications for HBOT treatments associated with a positive outcome in this case series included resistant bacterial infections, electrical cord injury, bite wound injuries, osteomyelitis, crush/traumatic injuries including mandibular fractures, oral surgery performed at previously irradiated sites, and osteonecrosis, presumably radiation induced. Conditions within this case series that remained unchanged or were associated with partial improvement included preoperative treatment of stomatitis without steroid usage and delayed HBOT treatment for long-term endodontic health of laterally luxated immature permanent mandibular incisors. Eighty-eight percent of the HBOT sessions were tolerated well by the patients in this case series. The most common adverse event was mild anxiety. One patient required oral anxiolytic medications to complete the course of treatment. One patient experienced transient seizure activity and was able to complete that session as well as subsequent sessions at a lower chamber pressure. Future prospective studies are necessary to further evaluate and characterize the potential benefits of HBOT as well as to clarify optimal treatment protocols for specific conditions in veterinary dentistry and oral surgery. [ABSTRACT FROM AUTHOR]

Importance: This is the first reported case of fragrance products-induced recurrent oxidative hemolytic anemia in a dog, detailing the successful therapeutic approach employed. Case Presentation: A 4-year-old intact female Pomeranian dog presented with brown tongue, pigmenturia, peripheral edema, and vomiting. Blood smears revealed a high count of eccentrocytes and Heinz bodies, along with a precipitous decline in packed cell volume and an increase in blood methemoglobin levels, suggesting an oxidative hemolytic crisis. This clinicopathological pattern recurred several times after the patient returned home. Antioxidants, methylene blue, hyperbaric oxygen (HBO) therapy, and blood transfusion were successfully employed to address recurrent hemolytic anemia; however, oxidative hemolytic crises recurred. After the owner removed exposure to various home remedies and fragrances, the clinical signs and hemolytic crises did not recur. Conclusions and Relevance: Recurring oxidative hemolytic crises should raise suspicions of environmental toxicity, which, although harmless in small quantities to humans, can be devastating to small-breed dogs. In addition to removing the causative agents, methylene blue and other antioxidants, along with HBO, may be beneficial in the acute management of oxidative hemolytic anemia. [ABSTRACT FROM AUTHOR]

Introduction: The safety of hyperbaric oxygen treatment (HBO2) in patients with cardiovascular implanted electronic devices (CIED) remains unclear. Methods: We conducted a retrospective analysis of seven CIED patients (median age 79 [73–83] years, five males [71.4%]), including five with pacemakers and two with implantable cardioverter defibrillators (ICD), who underwent HBO2 between June 2013 and April 2023. During the initial session, electrocardiogram monitoring was conducted, and CIED checks were performed before and after the treatment. In addition, the medical records were scrutinized to identify any abnormal CIED operations. Results: All seven CIED patients underwent HBO2 within the safety pressure range specified by the CIED manufacturers or general pressure test by the International Organization for Standardization (2.5 [2.5–2.5] atmosphere absolute × 18 [5–20] sessions). When comparing the CIED parameters before and after HBO2, no significant changes were observed in the waveform amplitudes, pacing thresholds, lead impedance of the atrial and ventricular leads, or battery levels. All seven patients, including two with the rate response function activated, exhibited no significant changes in the pacing rate or pacing failure. Two ICD patients did not deactivate the therapy, including the defibrillation; however, they did not experience any arrhythmia or inappropriate ICD therapy during the HBO2. Conclusion: CIED patients who underwent HBO2 within the safety pressure range exhibited no significant changes in the parameters immediately after the HBO2 and had no observable abnormal CIED operations during the treatment. The safety of defibrillation by an ICD during HBO2 should be clarified. [ABSTRACT FROM AUTHOR]

MMP-8 protein, osteoblast cells, and osteoclasts are markers of bone remodeling. Combining α-mangostin with hyperbaric oxygen therapy can enhance bone regeneration during orthodontic retraction. The aim of the research is to assess the alveolar cell bone and MMP-8 expression for bone remodeling in endodontic retraction after α-mangostin administration and hyperbaric oxygen therapy. Short (orthodontic) elastomeric chain retraction was performed on 25 model animals over a 28-day period. The osteoblast and osteoclast bone cells were then stained with H and E, and immunohistochemistry was used to detect MMP-8 protein. The α-mangosteen, hyperbaric oxygen, and combination therapy group improved alveolar bone repair by increasing osteoblast cells and decreasing osteoclast cells, which corresponded to bone formation of matrix and an increase in MMP- 8 protein. α-mangosteen therapy or in combination with hyperbaric oxygen therapy improved MMP-8 protein expression in alveolar bone after orthodontic retraction, resulting in balanced generation of osteoblast and osteoclast cells. [ABSTRACT FROM AUTHOR]

Hyperbaric oxygen treatment (HBOT) can be utilised for necrotising soft tissue infections, clostridial myonecrosis (gas gangrene), crush injuries, acute traumatic ischaemia, delayed wound healing, and compromised skin grafts. Our case was a 17-month-old male patient with Noonan syndrome, idiopathic thrombocytopenic purpura, and bilateral undescended testicles. Haematoma and oedema developed in the scrotum and penis the day after bilateral orchiopexy and circumcision. Ischaemic appearances were observed on the penile and scrotal skin on the second postoperative day. Enoxaparin sodium and fresh frozen plasma were started on the recommendation of haematology. Hyperbaric oxygen treatment was initiated considering the possibility of tissue necrosis. We observed rapid healing within five days. We present this case to emphasise that HBOT may be considered as an additional treatment option in patients with similar conditions. To our knowledge, no similar cases have been reported in the literature. [ABSTRACT FROM AUTHOR]

Purpose: Our purpose was to determine changes in patient-reported hematuria and urinary symptoms after hyperbaric oxygen (HBO2) treatment for radiation cystitis (RC). Materials and Methods: We analyzed prospectively collected data from the Multicenter Registry for Hyperbaric Oxygen Therapy Consortium accumulated within a week of beginning and ending HBO2. Measures included the modified Radiation Therapy Oncology Group (RTOG) Hematuria Scale, Urinary Distress Inventory Short Form, and EuroQol Five Dimension Five Level instrument. RTOG hematuria and Urinary Distress Inventory Short Form scores were compared using the sign test. Logistic regression was used to evaluate characteristics associated with hematuria improvement. Results: A total of 470 registry patients had RC. The median age, number of HBO2 sessions, and years after radiation were 73 (IQR 12) years, 39 (IQR 10) sessions, and 5 (IQR 8) years, respectively. Eighty-four percent of patients (393/470) had prostate cancer--related radiation. EuroQol Five Dimension Five Level scores improved from 0.83 (IQR 0.14) to 0.85 (IQR 0.22; P < .001. Three hundred seventy patients had complete RTOG hematuria scores that improved from 2 (IQR 2) to 0 (IQR 2; P < .001. Two hundred forty-six patients had complete Urinary Distress Inventory Short Form ratings that decreased from 33.3 (IQR 44) to 22.2 (IQR 33; P < .001). Regression analysis of those with visible hematuria before HBO2 showed lower improvement odds associated with higher HBO2 hematuria scores (odds ratio [OR] 0.44, 95% CI 0.26-0.73; P < .01), a smoking history (OR 0.44, 95% CI 0.21-0.92; P [ .03), or a nonprostate cancer history (OR 0.32, 95% CI 0.10-0.99; P [ .05). Conclusions: HBO2 for RC improved reported hematuria, urinary function, and quality of life. Higher baseline hematuria scores, smoking, and nonprostate cancer history were associated with lower odds of hematuria improvement. [ABSTRACT FROM AUTHOR]

Tooth movement in orthodontic treatment relies on the remodeling capacity of alveolar bone and periodontal ligament in response to mechanical stimuli. Innovations are sought to optimize cellular responses at skeletal and dental levels, enabling controlled tooth movement. This study aimed to evaluate the effectiveness of hyperbaric oxygen therapy and Myrmecodia pendans extract from Ant nest plants in orthodontic tooth movement. This literature review focused on articles that met specific inclusion criteria: English publications reporting controlled trials investigating the effects of hyperbaric oxygen therapy and ant nest extract on orthodontic tooth movement, compared to no additional therapy or a placebo. PubMed, Google Scholar, ProQuest, ScienceDirect, and Wiley Online Library were utilized as search engines using relevant keywords. The results indicated that hyperbaric oxygen therapy and antnest extract administration have the potential to enhance orthodontic tooth movement through various mechanisms, including promoting bone remodeling, stimulating interaction between osteoclasts and osteoblasts, and increasing bone metabolism. These findings suggest the benefits of Hyperbaric oxygen therapy and antnest extract administration in orthodontic treatment. Further research is recommended. [ABSTRACT FROM AUTHOR]

Spinal cord ischemia (SCI) with paraplegia or paraparesis is a devastating complication of complex aortic repair (CAR). Treatment includes cerebrospinal fluid drainage, maintenance of hemoglobin concentration (>10 g/L), and elevating mean arterial blood pressure. Animal and human case series have reported improvements in SCI outcomes with hyperbaric oxygen therapy (HBOT). We reviewed our center's experience with HBOT as a rescue treatment for spinal cord ischemia post-CAR in addition to standard treatment. A retrospective review of the University Health Network's Hyperbaric Medicine Unit treatment database identified HBOT sessions for patients with SCI post-CAR between January 2013 and June 2021. Mean estimates of overall motor function scores were determined for postoperative, pre-HBOT, post-HBOT (within 4 hours of the final HBOT session), and at the final assessment (last available in-hospital evaluation) using a linear mixed model. A subgroup analysis compared the mean estimates of overall motor function scores between improvement and non-improvement groups at given timepoints. Improvement of motor function was defined as either a ≥2 point increase in overall muscle function score in patients with paraparesis or an upward change in motor deficit categorization (para/monoplegia, paraparesis, and no deficit). Subgroup analysis was performed by stratifying by improvement or non-improvement of motor function from pre-HBOT to final evaluation. Thirty patients were treated for SCI. Pre-HBOT, the motor deficit categorization was 10 paraplegia, three monoplegia, 16 paraparesis, and one unable to assess. At the final assessment, 14 patients demonstrated variable degrees of motor function improvement; eight patients demonstrated full motor function recovery. Seven of the 10 patients with paraplegia remained paraplegic despite HBOT. The estimated mean of overall muscle function score for pre-HBOT was 16.6 ± 2.9 (95% confidence interval [CI], 10.9-22.3) and for final assessment was 23.4 ± 2.9 (95% CI, 17.7-29.1). The estimated mean difference between pre-HBOT and final assessment overall muscle function score was 6.7 ± 3.1 (95% CI, 0.6-16.1). The estimated mean difference of the overall muscle function score between pre-HBOT and final assessment for the improved group was 16.6 ± 3.5 (95% CI, 7.5-25.7) vs −4.9 ± 4.2 (95% CI, −16.0 to 6.2) for the non-improved group. HBOT, in addition to standard treatment, may potentially improve recovery in spinal cord function following SCI post-CAR. However, the potential benefits of HBOT are not equally distributed among subgroups. [ABSTRACT FROM AUTHOR]

A mild pneumocoelom was diagnosed by computed tomography in a stranded juvenile loggerhead sea turtle (Caretta caretta). After gas extraction by ultrasound-guided puncture, the animal did not improve and was subjected to hyperbaric oxygen therapy (HBOT). After HBOT, the turtle developed marked subcutaneous emphysema and was found dead the following morning. Gross lesions included a distended right atrium with numerous gas bubbles within the epicardium, gas bubbles in the hepatic, gastric and mesenteric veins, a small gas-filled bulla in the left lung and diffuse haemorrhages in the encephalon. Histological lesions included gas-like emboli in the lumen of the right atrium with myocardial necrosis, gas-like emboli in the lumina of intestinal, pulmonary and renal blood vessels and severe meningeal haemorrhages. From a forensic pathology perspective, the subcutaneous emphysema of immediate onset after HBOT and the greater severity of the histological lesions in blood vessels, heart, lung and brain differentiate this case from other cases of gas embolism in turtles due to incidental capture. Two factors contributed to this outcome: the existence of a probably unresolved pneumocoelom and the application of HBOT without an initial diagnosis that accurately indicated its use. Therefore, as in human medicine, the use of HBOT in sea turtles with lung lesions and pneumocoelom is discouraged. This is the first description of an iatrogenic gas embolism in a sea turtle. [Display omitted] [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Cirugía Oral y Maxilofacial is the property of Sociedad Espanola de Cirugia Oral y Maxilofacial (SECOM) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Osteoradionecrosis is a condition in which the nonvital irradiated bone, fails to heal to over for three to six months, causing the bone to open and disrupt the mucosa or overlying skin without cancer recurrence. Osteoradionecrosis most often occurs at mandibular sites, one of the treatments is hyperbaric oxygen therapy (HBOT) but it's still a contradiction whether HBOT has a good effect or not. This study aims to determine the effectiveness of HBOT in osteoradionecrosis of the mandible. This scoping review was on studies reporting the use of HBOT in osteoradionecrosis of the mandible. Search for articles refers to Preferred Reporting Items for Systematic Review and Metaanalysis (PRISMA) through PubMed and Google Scholar that meet the criteria according to the PICO (Population, Intervention, Comparison, Outcome) framework. The filterings were the year published, indexed by Scopus, the title and abstract, and the contents of the entire article. There were 7 articles related to the administration of HBOT in the treatment of mandibular osteoradionecrosis with the majority as multimodality therapy. HBOT has a positive role in the healing process of mandibular osteoradionecrosis, especially as a multimodality therapy. [ABSTRACT FROM AUTHOR]

The article discusses the important role of veterinary dental technicians in the field of veterinary dentistry. While dentists often receive the most attention, dental technicians play a crucial role in patient care before and after dental procedures. They are responsible for conducting dental examinations, taking radiographs, gathering patient history, monitoring recovery, administering medications, and educating pet owners on postoperative care. Dental technicians also have the skills to perform various dental procedures and contribute to the efficiency of the dental practice by managing administrative tasks and ensuring the availability of necessary supplies. The collaboration between dental technicians and dentists allows for continuous professional development and ensures that both professionals stay updated on advancements in the field. Overall, veterinary dental technicians make invaluable contributions to the quality of dental care provided to animal patients. [Extracted from the article]

Hyperbaric oxygen (HBO) therapy involves intermittent inhalation by the patient of 100% oxygen under a pressure greater than 1 atmosphere. Both therapeutic and toxic effects can result from two features of this form of treatment; mechanical effects arising from exposure to increased ambient pressure and the physiological effects of hyperoxia. Substantial evidence supports the use of HBO therapy in certain carefully defined settings, though many patients who might benefit go untreated because of their physicians' unfamiliarity with recent research and overall uncertainty about the legitimacy of HBO as a therapy. The author discusses the mechanism of action of HBO therapy and the commonly accepted clinical indications. [ABSTRACT FROM AUTHOR]

The Journal of Urology Home Study Course 2024 Volume 211/212 is a comprehensive learning activity designed for practicing urologic physicians, American Board of Urology candidates, and residents. The course consists of two volumes published annually, each containing six issues. Participants can earn up to 2.0 AMA PRA Category 1 Credits for each issue by reading the educational material, passing an online posttest, and submitting an evaluation. The American Urological Association ensures that the content is valid, fair, balanced, scientifically rigorous, and free of commercial bias. The course is accredited by the Accreditation Council for Continuing Medical Education, and participants who are not MDs or DOs can receive documentation of participation. The course covers various urology topics and includes articles on prostate cancer, hyperbaric oxygen therapy, renal function, prophylactic mesh, and retrograde intrarenal surgery. [Extracted from the article]

This article discusses the use of hyperbaric oxygen (HBO2) therapy as a treatment for radiation cystitis (RC), a bladder condition that can occur after pelvic radiation. The study examines the outcomes of patients undergoing HBO2 therapy for RC and finds that 66% of patients had positive results, with a decrease in hematuria (blood in urine) and urinary symptoms. The study also identifies factors that may affect the success of HBO2 therapy, such as the type of cancer and other medical conditions. However, the findings should be interpreted with caution due to limitations in data collection and the absence of a control group. The authors emphasize the need for further research in this area to better understand the use of HBO2 therapy for RC patients. [Extracted from the article]

The Journal of Urology published an article titled "Editor's Choice" that discusses three different studies. The first study focuses on the use of hyperbaric oxygen therapy for radiation cystitis, finding that it can be beneficial for patients with recurrent symptoms. The second study compares the safety and effectiveness of radiation-free retrograde intrarenal surgery (RIRS) to traditional RIRS using fluoroscopy, concluding that radiation-free RIRS is a viable alternative that minimizes radiation exposure without compromising surgical outcomes. The third study examines the effectiveness of using prophylactic biologic mesh to prevent parastomal hernias after creating an ileal conduit, finding that while the use of biologic mesh is safe, it does not significantly protect against parastomal hernias in the short to medium term. [Extracted from the article]

This systematic review aims to provide an overview of the literature on the effect of hyperbaric oxygen therapy (HBOT) on symptoms of local late radiation toxicity (LRT) in patients treated for breast cancer. A systematic search was performed in September 2021. All studies with a sample size of ≥10 patients reporting the effect of HBOT for symptoms of LRT after radiotherapy of the breast and/or chest wall were included. The ROBINS-I tool was used for critical appraisal of methodological quality. The toxicity outcomes pain, fibrosis, lymphedema, necrosis/skin problems, arm and shoulder mobility, and breast and arm symptoms were evaluated. Nine studies concerning a total of 1308 patients were included in this review. Except for one study, sample sizes were small. Most studies had inadequate methodology with a substantial risk of bias. Post-HBOT, a significant reduction of pain was observed in 4/5 studies, of fibrosis in 1/2 studies, and of lymphedema of the breast and/or arm in 4/7 studies. Skin problems of the breast were significantly reduced in 1/2 studies, arm- and shoulder mobility significantly improved in 2/2 studies, and breast- and arm symptoms were significantly reduced in one study. This systematic review indicates that HBOT might be useful for reducing symptoms of LRT in breast cancer patients, however evidence is limited. A randomized controlled trial in a larger cohort of patients including a combination of patient- and clinician-reported outcome measures would be valuable to assess the effect of HBOT on symptoms of LRT. • Pain significantly reduced in four out of five studies. • Fibrosis significantly reduced in one out of two studies. • Lymphedema of the breast and arm significantly reduced in four out of seven studies. • A randomized controlled trial is recommended for future research. • A combination of patient- and clinician reported outcome measures would be valuable. [ABSTRACT FROM AUTHOR]

Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the effect of using a combination of Channa Striata gel and hyperbaric oxygen therapy on pressure areas during orthodontic treatment. Material and Methods: The study was conducted using the ARRIVE Essential 10 guidelines. In this study, 35 3-4 months male guinea pigs (Cavia Cobaya) weighing 300- 400 grams were used and divided into 5 groups (n=7). Decalcification was performed to dissolve the dental calcium and jawbone to cut the tissue properly. The decalcification was performed for 30 days. Then preparations were made with HE (Hematoxylin Eosin), observed using a microscope, and counted the number of osteoclasts and macrophages on a light microscope with 400 times magnification. The results of the preparations were analyzed using the SPSS program. Results: The Kruskal-Wallis test of macrophage cells and the ANOVA test of osteoclast cells showed significant results between all groups (p<0.05). Conclusion: The effect of hyperbaric oxygen therapy 2,4 ATA administered on days 8-14 and Channa Striata extract gel administered on days 3-14 can increase the number of macrophages in the periodontal ligament and osteoclasts in the alveolar bone in the pressure area during orthodontic tooth movement. [ABSTRACT FROM AUTHOR]

Malocclusion remarkably prevails in 56% of the global population. This study has aims analyzing the HBOT method and S. hermanii gel incorporation in the alveolar bone remodeling advancement during the orthodontic tooth movement with TRAP-6, OPG, and ALP as biomarker. Thirty male guinea pigs, was randomized into five groups: Normal control group (NT), negative control group (NC) Helical springs were inserted during 14 days without any administration, Treatment group 1 (T1). Helical springs were inserted with S. hermanii gel administration at days 3 to 14, Treatment group 2 (T2) with HBOT treatment from 8 to 14 days at 2.4 ATA, Treatment group 3 (T3) with both administrations of S. Hermanii and HBOT treatment. The parameters stained through immunohistochemical (IHC) method. Positive expression of TRAP-6, OPG, and ALP was assessed semi-quantitatively according to the modified Kaemmerer method and were evaluated by using Kruskal Wallis and Mann Whitney tests (P < 0.05). The administration of combined treatments of S. Hermanii and HBOT was proven to increase the ALP and OPG expression and decrease the TRAP-6 expression, compared to NC and NT (p=0.05). The combined treatments did not affect the ALP expression significantly compared to the S. Hermanii-only group, which indicates that the elevated ALP expression was predominantly affected by the S. Hermanii components also OPG expression due to flavonoids, arginine, and the chondroitin sulfate components. the combined treatments did not lower the TRAP-6 significantly compared to the HBOT-only group, which indicates a predominant portion of oxygen exposure in the TRAP-6 decrease. [ABSTRACT FROM AUTHOR]

Purpose Almost 95% of patients undergoing radiotherapy treatments will develop a form of radiodermatitis. Despite this prevalence, treatment recommendations lack consensus, and clinical practices differ. The purpose of this scoping review is to examine the literature for radiodermatitis treatment options occurring in persons with head and neck, as well as breast, cancer and to report the pain felt by these populations after receiving radiotherapy. Methods A scoping review based on the Preferred Reporting Items for Systematic reviews and Meta-analyses extension for Scoping Reviews (PRISMA&lowbar;Sc-R) checklist was performed. To identify the sources of evidence, the MEDLINE, CINAHL, Cochrane, LiSSA and Google Scholar databases were searched. All available articles published in the French and English languages were included. Results Two hundred fifty-five studies met the inclusion criteria. The included studies demonstrated heterogeneous results, owing to significant variations in the interventions, the controls and the assessment tools. The quality of the evidence was found to be low and at high risk for biases. Conclusion This scoping review provides a broad overview of the available data and highlights the paucity of highquality evidence to guide therapeutic interventions for the optimal management of radiodermatitis. Since radiodermatitis is a common injury of radiotherapy for breast cancer and head and neck cancer, more research is needed to guide the prevention and treatment of radiodermatitis for patients suffering from this complication. [ABSTRACT FROM AUTHOR]

So called Caisson's disease of bone is well recognized in the literature. The purpose of this paper is to move away from simply considering the orthopaedic aspects of avascular injury to bones and joints and provide some background physiology and physics to help understand the challenges encountered whilst diving. This is relevant to those working with professional divers. Either commercially or within the military setting, and some guidance will be provided for those involved in the acute care of divers injured or affected by the problems covered within this article. It is recommended that acute units that deal with diving accidents have established protocols to deal with the issues covered, including access to hyperbaric chambers. [ABSTRACT FROM AUTHOR]

Deep caries could harm the vitality of the pulp, so it is necessary to protect the pulp with pulp capping procedure. Pulp capping material will release growth factors, one of it is TGF-β which plays a role in pulp tissue repair. Hyperbaric Oxygen Therapy (HBOT) is a treatment that can be used as an adjunct therapy in wound healing. TGF-β levels can be increased by HBOT procedure. This study aimed to determine the role of HBOT on the success of pulp capping treatment in terms of increasing levels of growth factor TGF-β. A scoping review was conducted refers to PRISMA Extension for Scoping Reviews (PRISMA-ScR) Protocols through 4 databases included PubMed, Science Direct, Wiley Online Library and Google Scholar. Inclusion and exclusion criteria according to the Population, Concept, and Context (PCC) framework. A total 6 articles showed an enhancing in TGF-β levels after HBOT with difference of HBOT treatment, other treatment, and measurement of TGF-β expression. Administration of HBOT will increase levels of TGF-β growth factor in the process of tissue repair. Thus, has the potential to increase the success of pulp capping treatment in terms of increasing levels of TGF-β growth factor. [ABSTRACT FROM AUTHOR]

Successful treatment of diabetic wounds requires multifactorial approaches. Herein we investigated the effects of a bioengineered three-dimensional dermal derived matrix-scaffold (DMS) in combination with hyperbaric oxygen (HBO) in repairing of wound model in diabetic rats. Thirty days after induction of diabetes, a circular wound was created and treatments were performed for 21 days. Animals were randomly allocated into the untreated group, DMS group, HBO group, and DMS+HBO group. On days 7, 14, and 21, tissue samples were obtained for stereological, molecular, and tensiometrical assessments. Our results showed that the wound closure rate, volume of new dermis and epidermis, numerical density fibroblasts and blood vessels, collagen density, and biomechanical characterize were significantly higher in the treatment groups than in the untreated group, and these changes were more obvious in the DMS+HBO ones. Moreover, the expression of TGF-β , bFGF , miRNA-21 , miRNA-146a , and VEGF genes were meaningfully upregulated in treatment groups compared to the untreated group and were greater in the DMS+HBO group. This is while expression of TNF-α and IL-1β , as well as the numerical density of neutrophil and macrophage decreased more considerably in the DMS+HBO group than in the other groups. Overall, using both DMS engraftment and HBO treatment has more effects on diabetic wound healing. • The DMS and HBO increase the amount of collagen. • The DMS and HBO improve the stereological characteristics. • The DMS and HBO regulate the inflammatory process. • The DMS and HBO upregulated regenerative genes. • The DMS and HBO improve biomechanical characteristics. [ABSTRACT FROM AUTHOR]

Traumatic spinal cord injury (TSCI) is one of the catastrophic events in the nervous system that leads to the loss of sensory and motor function of the spinal cord at the site of injury. Considering that several factors such as apoptosis, inflammation, and oxidative stress play a role in the spread of damage caused by trauma, therefore, the treatment should also be based on multifactorial approaches. Currently, we investigated the effects of human menstrual blood stem cells (MenSCs)-derived exosomes in combination with hyperbaric oxygen therapy (HBOT) in the recovery of TSCI in rats. Ninety male mature Sprague-Dawley (SD) rats were planned into five equal groups, including; control group, TSCI group, Exo group (underwent TSCI and received MenSCs -derived exosomes), HBOT group (underwent TSCI and received HBOT), and Exo+HBOT group (underwent TSCI and received MenSCs -derived exosomes plus HBOT). After the behavioral evaluation, tissue samples were obtained for stereological, immunohistochemical, biochemical, and molecular assessments. Our results showed that the numerical density of neurons, the concentrations of antioxidative biomarkers (CAT, GSH, and SOD), and neurological function scores were significantly greater in the treatments group than in the TSCI group, and these changes were more obvious in the Exo+HBOT ones (P<0.05). This is while the numerical densities of apoptotic cells and glial cells, the levels of an oxidative factor (MDA) and proinflammatory cytokines (IL-1β and TNF-α) were considerably decreased in the treatment groups, specially the Exo+HBOT group, compared to the TSCI group (P<0.05). We conclude that the co-administration of exosomes derived from MenSCs and HBOT has more neuroprotective effects in animals with TSCI. • We studied the effects of MenSCs-derived exosomes and HBOT treatment following spinal cord injury. • Treatment improved rehabilitation of motor function after spinal cord injury. • Treatment increased the survival of motor neurons and reduced the glial cells after spinal cord injury. • Treatment inhibited apoptosis and neuroinflammation in spinal cord injury. • Treatment attenuated oxidative stress in spinal cord injury. [ABSTRACT FROM AUTHOR]

774 PATIENT- REPORTED OUTCOMES FOLLOWING HBO2 FOR RADIATION CYSTITISRegistry for Hyperbaric Oxygen Therapy. J Urol. 2024; 211( 6): 765- 774. Copyright © 2024 American Urological Association Education and Research, Inc. Unauthorized reproduction of this article is prohibited. [Extracted from the article]

Rehabilitation of a post-exenterated orbital defect is a necessity, to restore a patient's esthetic appearance and help overcome the associated psychosocial stigma. An implant supported prosthesis enjoys a better patient acceptance due to its superior retention and stability. This clinical report highlights the challenges faced in planning, designing and placement of maxillofacial implants in the supra-orbital rim of an exenterated socket post-radiotherapy along with the management of the unexpected complications which developed subsequently. Administration of hyperbaric oxygen therapy, fabrication of a digitally designed surgical guide to ensure predictable implant placement, selection of surface treated implants for better biomechanical anchorage, and a gentler surgical technique for recovery of irradiated hard and soft tissues were measures undertaken during the treatment phase. An effort has been made to point-out the fact that despite the various approaches adopted in an irradiated patient, success of implant placement in such a situation remains a challenge. [Display omitted] [ABSTRACT FROM AUTHOR]

Purpose: Hemorrhagic cystitis (HC) which occurs in 9%--31% of recipients after hematopoietic stem cell transplantation (HSCT) is an important cause of morbidity and mortality. Various treatment approaches have been applied for such as conservative treatments (hydration, analgesic agents, antibiotics), intravesical treatments (bladder irrigation, hyaluronic acid, and prostaglandin E), intravenous or intravesical antiviral agents, hyperbaric oxygen, and surgical treatments. Materials and Methods: This retrospective study included two hundred thirty-three children who underwent HSCT in Pediatric Bone Marrow Transplantation unit between April 2010 and June 2017. Results: Ten patients (4.2%) developed HC. The mean age of patients was 12.8 years and the mean duration of the onset of HC was 20 days. Urine and blood BK polyomavirus were positive in nine and four patients, respectively. Six patients received intravesical hyaluronic acid, three patients received intravesical prostaglandin E, three patients received intravenous ganciclovir, two patients received intravenous and/or intravesical cidofovir and hyperbaric oxygen treatment. The mean time of recovery from hematuria was 43 days. This study showed that the BK polyomavirus has an important role in the development of HC in HSCT patients, as in harmony with the literature. HC has been successfully treated in eight patients with supportive measures and/or intravesical hyaluronic acid. Conclusions: BK polyomavirus plays an important role in the development of HC pediatric patients. Intravesical hyaluronic acid, besides supportive measures, was effective for the treatment of HC and hyperbaric oxygen may be reserved for refractory cases. [ABSTRACT FROM AUTHOR]

Nickel material is long-established used in dentistry due to its several advantages. Nickel's use in the alloy is mainly because of the reasonable price compared to precious alloy, has sufficient hardness, and good physical and mechanical properties. However, the use of Nickel has a risk of causing an allergic reaction, that is, type IV hypersensitivity. Nickel allergy prevention can be done by genetic therapy but at an expensive cost. This study used an alternative hyperbaric oxygen therapy (HBOT) 2,4 ATA, which has anti-inflammatory effects, inhibits inflammatory cytokines, and affects epithelial thickness. This study was carried out to determine the influence of HBOT on changes in the number of macrophages cells, neutrophils cells, and epithelial thickness in inflammation caused by hypersensitivity reaction of BALB/C mice induced by Nickel. Fifteen BALB/C mice were randomly divided into three groups: a negative control group without therapy, a positive control group using corticosteroid therapy, and an HBOT group. All groups were given an intraperitoneal injection of NiCl2+IFA on the first sensitization and NiCl2+CFA on the second sensitization intradermally. The positive control group was given the corticosteroid dexamethasone at a dose of 0.02 mg/mouse/day on days 11-13; the HBOT group was given HBOT 2.4 ATA for 3x30 minutes with 5-minute intervals for three days on days 11-13. The ears of BALB/C mice were taken 48 hours after the second injection and examined with Haematoxylin Eosin staining. The data were analyzed by using One Way ANOVA and Tukey-HSD test. There were a significant decrease in the epithelial thickness and both macrophages and neutrophil cells by using HBOT. It was shown that HBOT effectively reduced inflammation in the ears of mice with nickel hypersensitivity. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Cirugía Oral y Maxilofacial is the property of Sociedad Espanola de Cirugia Oral y Maxilofacial (SECOM) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chronic wound is a serious medical issue due to its high prevalence and complications; hyperbaric oxygen therapy (HBOT) is also considered in comprehensive treatment. Clinical trials, including large meta-analyses bring inconsistent results about HBOT efficacy. This review is summarizing the possible effect of HBOT on the healing of chronic wound models at the cellular level. HBOT undoubtedly escalates the production of reactive oxygen and nitrogen radicals (ROS and RNS), which underlie both the therapeutic and toxic effects of HBOT on certain tissues. HBOT paradoxically elevates the concentration of Hypoxia inducible factor (HIF) 1 by diverting the HIF-1 degradation to pathways that are independent of the oxygen concentration. Elevated HIF-1 stimulates the production of different growth factors, boosting the healing process. HBOT supports synthesis of Heat shock proteins (HSP), which are serving as chaperones of HIF-1. HBOT has antimicrobial effect, increases the effectiveness of some antibiotics, stimulates fibroblasts growth, collagen synthesis and suppresses the activity of proteolytic enzymes like matrix metalloproteinases. All effects of HBOT were investigated on cell cultures and animal models, the limitation of their translation is discussed at the end of this review. [ABSTRACT FROM AUTHOR]

Benign subcutaneous emphysema of the upper limb is extremely uncommon. Patients with this condition that involves the limbs usually present with local symptoms, and they are systematically well. We report a case of 18-year-old male presented after a minor cut wound in the forearm with diffuse subcutaneous emphysema. The patient was treated with hyperbaric oxygen therapy after wound exploration. Recovery was uneventful. Infectious etiology by gas-forming organisms should be ruled out before considering other causes. [ABSTRACT FROM AUTHOR]

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetic foot ulcer (DFU) is a serious complication of diabetes and hyperbaric oxygen therapy (HBOT) is also considered in comprehensive treatment. The evidence supporting the use of HBOT in DFU treatment is controversial. The aim of this work was to introduce a DFU model in ZDF rat by creating a wound on the back of an animal and to investigate the effect of HBOT on the defect by macroscopic evaluation, quantitative histological evaluation of collagen (types I and III), evaluation of angiogenesis and determination of interleukin 6 (IL6) levels in the plasma. The study included 10 rats in the control group (CONT) and 10 in the HBOT group, who underwent HBOT in standard clinical regimen. Histological evaluation was performed on the 18th day after induction of defect. The results show that HBOT did not affect the macroscopic size of the defect nor IL6 plasma levels. A volume fraction of type I collagen was slightly increased by HBOT without reaching statistical significance (1.35±0.49 and 1.94±0.67 %, CONT and HBOT, respectively). In contrast, the collagen type III volume fraction was ~120 % higher in HBOT wounds (1.41±0.81 %) than in CONT ones (0.63±0.37 %; p=0.046). In addition, the ratio of the volume fraction of both collagens in the wound ((I+III)w) to the volume fraction of both collagens in the adjacent healthy skin ((I+III)h) was ~65 % higher in rats subjected to HBOT (8.9±3.07 vs. 5.38±1.86 %, HBOT and CONT, respectively; p=0.028). Vessels density (number per 1 mm2) was found to be higher in CONT vs. HBOT (206.5±41.8 and 124±28.2, respectively, p<0.001). Our study suggests that HBOT promotes collagen III formation and decreases the number of newly formed vessels at the early phases of healing. [ABSTRACT FROM AUTHOR]

Radiotherapy of pelvic cancers may cause severe tissue injuries, and hyperbaric oxygen therapy (HBOT) is one of few treatment alternatives. As part of a longitudinal, mixed-methods study, this study's aim was to explore pelvic cancer survivors' experiences of undergoing such treatment. Using a phenomenological-hermeneutical design, in-depth interviews of 20 cancer survivors were conducted and analysed using systematic text condensation. This study is reported in accordance with COREQ. The informants' experiences were identified as: Approaching an unknown world, From feeling worried to becoming familiar, A long-lasting treatment course, and The treatment course went better than expected. Despite information prior to the treatment, informants were worried about HBOT but were still motivated to try it. A combination of relevant information, clear routines, person-centred care, peer support, and limited side effects seem to be important factors for patients' experiences of safety from this treatment. [ABSTRACT FROM AUTHOR]

This study was a systematic review with meta-analysis to evaluate the influence of hyperbaric oxygen therapy (HBOT) on the survival of dental implants placed in patients who had had radiotherapy for cancer of the head and neck. A systematic literature search was conducted using the PubMed/Medline, Science Direct, Embase and the Cochrane Library, between January 1985 and July 2018. The study observed the PRISMA (Preferred Reporting Items for Systematic review and Meta-Analysis) declaration and norms, and the systematic review was duly recorded in the PROSPERO (International prospective register of systematic reviews) database. Inclusion and exclusion criteria were applied, and all articles were selected on the basis of PICO questions. The process of eligibility and quality evaluation yielded three studies for statistical analysis. Based on the survival rates, there was no evidence that the risk of an implant failing was different between the patients who received HBOT and those who did not. Moreover, the risk of an implant failing did not depend on the anatomical site. HBOT exerted no beneficial influence on the survival rates of implants placed in irradiated patients, and the risk of an implant failing did not depend on its location. [ABSTRACT FROM AUTHOR]

Abstract: Passive recovery techniques are popular and offer a diverse spectrum of options for athletes and the clinicians providing care for them. These techniques are intended to minimize the negative effects of training or competition, thus enabling the athlete a quicker return to peak performance. Current evidence demonstrates improved athlete recovery with compression garments, cold water immersion, partial body cryotherapy, hyperbaric oxygen, and vibratory therapies. Other popular modalities, such as compression devices, whole body cryotherapy, percussive gun-assisted therapy, neuromuscular electrical stimulation, and pulsed electromagnetic therapy lack convincing evidence concerning athlete recovery. This article seeks to review the current literature and offer the reader an updated understanding of the mechanisms for each modality and the evidence regarding each modality's potential benefit in an athlete's recovery strategy. [ABSTRACT FROM AUTHOR]

Introduction: Hyperbaric oxygen (HBO) therapy may be a useful treatment to prevent the development of delayed neuropsychiatric sequelae (DNS) in patients with acute carbon monoxide (CO) poisoning. However, there is no clear consensus regarding the optimal number of HBO therapy sessions in patients with CO poisoning. Here, we compared the development of DNS after 3 and > 3 sessions of HBO therapy in patients with acute CO poisoning.Methods: This prospective observational study recruited 299 patients with CO poisoning. Demographic and clinical information were obtained, including comorbidities, vital signs, and symptoms. Patients were divided into two groups according to whether they received 3 or > 3 sessions of HBO therapy (3 HBO vs. >3 HBO). A propensity score-matching process was used to balance potential prognostic factors in both groups.Results: Of the 299 patients with acute CO poisoning enrolled in this study, 183 (59.0%) were included in the analysis. Patients were excluded for the following reasons: age < 18 years, not underwent HBO therapy, discharged against medical advice, and loss to follow-up. The overall rate of DNS development was 17.5%. The >3 HBO group had a higher incidence of DNS development compared to the 3 HBO group (36.3% vs. 16.3%; p = 0.09). Propensity score-matching analysis revealed similar incidences of DNS (31.3% vs. 28.1%, respectively; p > 0.99).Conclusions: There is a critical need to determine the optimal number of HBO therapy sessions for patients with acute CO poisoning. This study showed no difference in DNS development after 3 and > 3 sessions of HBO therapy. [ABSTRACT FROM AUTHOR]

The article discusses effect of Hyperbaric Oxygen Therapy (HBOT) on speech production in children with Cerebral Palsy (CP). It mentions that children with CP have a smaller overall vowel space and more variability of formant values of individual vowels and the vowel space of individual vowels thus overlap more. It also mentions that birth complications cause most cases of cerebral palsy.

For decades, hyperbaric oxygen (HBO) has often been part of the treatment of osteoradionecrosis (ORN), despite controversy in the literature about its efficacy. An online survey was conducted to investigate the use of HBO in the treatment of ORN by Dutch oral and maxillofacial surgeons and to assess their perception of its efficacy. Of the 53 Dutch oral and maxillofacial surgery units contacted, 49 (92%) replied. Thirty-five were not head and neck cancer (HNC) units or preferred partner (PP-HNC) units recognized by the Dutch Head and Neck Association. All HNC and PP-HNC units (group 1) treated ORN patients, compared to only 12 (34%) of the non-HNC units (group 2). The average number of ORN patients seen and treated was higher in group 1. The units in group 1 more often referred patients for HBO therapy (HBOT) than those in group 2 (93% vs 84%). The efficacy of HBOT in curing ORN, rated on a scale of 1 to 5 points, was 3.7 in group 1 and 3.2 in group 2. This survey shows a trend towards centralization of ORN care to more experienced units. These units tend to use HBOT in curing ORN. [ABSTRACT FROM AUTHOR]

The loss of continuity of the nerve structure interrupts the transmission of nerve impulses and leads to the disorganization of functional activities. Many methods, as the use of neurogenic factors, aid in the process of neural regeneration by accelerating or improving peripheral nerves neoformation. The adipose tissue is abundant in the human body, and it has presented promising results in the regeneration of peripheral nerves. We carried out a randomized controlled study in 9 months, using 45 male Wistar rats, 80 days old, and the sciatic nerve was chosen for analysis. The control animals were divided into three groups - Initial group (IG), Final group (FG), and denervated group (DG) - with seven animals each. The experimental groups, with twelve animals each, were polyethylene tube filled with fat (EGF) and polyethylene tube without filling (EGwf). All groups, except IG, were submitted to 10 sessions of hyperbaric oxygen treatment of 1h 45 min in alternating days. Functional evaluation by walking-track was assessed using the Catwalk XT® software and tissues were harvested and stained with 1% toluidine blue for histological analysis. Quantitative data were first analyzed with the Kolmogorov Smirnov normality test. Comparison between the four groups was analyzed by ANOVA followed by Tukey Test. We concluded that hyperbaric oxygen therapy had positive results on morphometric and functional parameters. However, no significant differences were found regarding the use of autologous fat graft. [ABSTRACT FROM AUTHOR]

It has been found that insulin resistance (IR) affects majority of the women with polycystic ovarian syndrome (PCOS) regardless its correlation with obesity. Hyperinsulinemia leads to hyperandrogenemia state, showed by an over-expression in androgen receptor (AR). It has also been discovered that oxidative stress level is significantly increased in patients with PCOS, showed by an increase in superoxide dismutase (SOD) serum level. Hyperbaric oxygen therapy (HBOT) is proved to be able to reduce IR and oxidative stress level in other cases. This study aims to evaluate the effect of HBOT on AR expression and SOD serum level in insulin-resistant PCOS rat model. This study was an experimental study with randomized posttest only control group design. Twenty female Rattus norvegicus strain Wistar as insulin-resistant PCOS rat model was used in this study, randomly divided into control group and treatment group. HBOT was given at 2.4 ATA pressure with 100% oxygen. AR expression was measured semi-quantitatively with Immunoreactive Score (IRS), while SOD serum level was measured with ELISA method. Mean IRS score between control group and treatment group were significantly different (1.64 ± 1.38 vs 0.8 ± 0.6, p = 0.025). Mean SOD serum level between control group and treatment group was significantly different (0.13 ± 0.03ng/ml vs 0.2 ± 0.06ng/ml, p = 0.011). HBOT could reduce the AR expression and increase the SOD serum level in insulin-resistant PCOS rat model. HBOT therapy could be taken into consideration for treating insulin-resistant PCOS patients. [ABSTRACT FROM AUTHOR]

Copyright of Acta Medica Croatica is the property of Croatian Academy of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: This study aims to assess whether hyperbaric oxygen (HBO) applied immediately after tooth extraction could ameliorate medication‐related osteonecrosis of the jaw in rats. Methods: To evaluate whether osteonecrosis could be successfully induced, healing of extraction maxillary molars was examined in 40 female Sprague Dawley rats received zoledronic acid (7.5 µg/kg) plus dexamethasone (1 mg/kg). Rats were divided into four groups, receiving zero, two, four, or seven injection(s) for 7 days, respectively. Effect of HBO, pressurized to 2.5 atmospheres absolute (ATA) at rate of 0.15 ATA/min with 100% oxygen for 90 minutes, applied immediately after tooth extraction, on the development of osteonecrosis was evaluated. Lesions among groups were compared by size of ulceration, exact area (mm2) or relative area (%), and by histology. Results: Unhealed ridge was observed in all nine rats in four and seven injection groups, but none of 10 rats in the control (non‐injection) group. Immediate HBO significantly reduced the lesions in rats that received four injections, regardless of the distribution and the total/relative areas of lesions (P <0.01). Histological findings showed the lesions were uncovered epithelium and severe tissue inflammation. Conclusion: This is the first in vivo study demonstrating the HBO applied immediately after tooth extraction effectively decreases the development of medication‐related osteonecrosis. [ABSTRACT FROM AUTHOR]

Problem in the orthodontic sometimes needs a long-term treatment, about 24 months. One of some efforts that might be useful to accelerate the orthodontic treatment is by adding hyperbaric oxygen (HBO), this HBO is known as a treat that for successfully heal wound in tissue and supports the vascularization. During orthodontic treatment, bone remodeling is a vital process. The aim of this study is to investigate VEGF regulates osteoblast differentiation (osteocalcin parameter) in tension and pressure regions during orthodontic tooth movement administered with HBO. Twentyfour male guinea pigs divided into three equal groups, namely (K0) as the control group, (K1) as the orthodontic group, and (K2) as the HBO group. HBO therapy was used at 2.4 ATA for 90 minutes in 7 days, from day 8 to day 14. VEGF and osteocalcin were examined with immunohistochemistry method. The data were evaluated by using Kruskal Wallis and Mann Whitney tests (P < 0.05). Correlation was used Pearson Test. There was increasing VEGF and Osteocalcin giving by HBO, except osteocalcin in pressure regions. Correlation test showed strong correlation between VEGF and osteocalcin with coefficient value 0.643. The provision of HBO therapy can increase VEGF dan osteocalcin expression in the tension region, higher than in the pressure region. VEGF expression and osteocalcin were related simultaneously with strong correlation, when VEGF can induces the expression of osteocalcin, a late marker of differentiation. [ABSTRACT FROM AUTHOR]