37 results on '"Gerpe A"'
Search Results
2. VERIFICACIÓN DE LA ESTRUCTURA INTERNA DE UN CUESTIONARIO PARA EL ESTUDIO DE LA DISCAPACIDAD EN LA EDUCACIÓN SUPERIOR (CEDES).
- Author
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Gerpe Pérez, Enelina María
- Subjects
EXPLORATORY factor analysis ,FACTOR analysis ,DISABILITIES ,FACTOR structure ,STUDENTS ,STUDENTS with disabilities ,COLLEGE students ,INCLUSION (Disability rights) - Abstract
Copyright of Innovacion Educativa is the property of Universidad de Santiago de Compostela, Servicio de Publicaciones and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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- View/download PDF
3. Metataxonomic analysis of tissue-associated microbiota in grooved carpet-shell (Ruditapes decussatus) and Manila (Ruditapes philippinarum) clams
- Author
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Gerpe, Diego, Lasa, Aide, Lema, Alberto, and Romalde, Jesús L.
- Abstract
Culture-dependent techniques only permit the study of a low percentage of the microbiota diversity in the environment. The introduction of next generation sequencing (NGS) technologies shed light into this hidden microbial world, providing a better knowledge on the general microbiota and, specifically, on the microbial populations of clams. Tissue-associated microbiota of Ruditapes decussatusand Ruditapes philippinarum(mantle, gills, gonad and hepatopancreas) was analysed in two different locations of Galicia (northwest of Spain) during Spring (April) and Autumn (October), employing a metataxonomic approach. High bacterial diversity and richness were found in all samples where a total of 22,044 OTUs were obtained. In most samples, phylum Proteobacteriawas most frequently retrieved, although other phyla as Actinobacteria, Bacteroidetes, Tenericutes, Firmicutesor Chlamydiaealso appeared at high relative abundances in the samples. At genus level, great variation was found across tissues and sampling periods. A Nonmetric Multidimensional Scaling (NMDS) and a hierarchical clustering analysis allowed to further analyse the factors responsible for the differences among groups of samples in the different sites. Results showed sample ordination based on tissue origin and sampling periods, pointing out that the microbiota was influenced by these factors. Indeed, predominance of certain genera was observed, such as Endozoicomonasor Methylobacteriumin gills and gonads, respectively, suggesting that selection of specific bacterial taxa is likely to occur. So far, this study provided a general picture of the tissue associated microbial population structure in R. decussatusand R. philippinarumclams, which, ultimately, allowed the identification of specific tissue-related taxa.
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- 2021
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4. Toxicological responses of Laeonereis acuta (Polychaeta, Nereididae) after acute, subchronic and chronic exposure to cadmium.
- Author
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Dolagaratz Carricavur, Arantxa, Chiodi Boudet, Leila, Romero, María Belén, Polizzi, Paula, Marcovecchio, Jorge Eduardo, and Gerpe, Marcela
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POLYCHAETA ,NEREIDAE ,PHYSIOLOGICAL effects of cadmium ,ACUTE toxicity testing ,LAEONEREIS ,LIPID peroxidation (Biology) - Abstract
The objective of this study was to analyze the toxicological responses of the estuarine polychaete Laeonereis acuta after acute (96 h), subchronic (7 days) and chronic (14 days) exposure to cadmium (Cd). Concentrations of metallothioneins (MT), lipid peroxidation (LPO), total Cd and metal-rich granules (MRG) were evaluated. Seasonal variations of MT and LPO levels in the wild were also measured. Polychaetes were obtained in the Quequén estuary located southeast of Buenos Aires Province, Argentina. For the acute toxicity assay, individuals were exposed to 10; 30, 65; 310; 600; 1300; 2000; 4300; 8100; 16300 µgCd L −1 , which included levels of environmental relevance and median lethal concentrations (LC 50 ) for related species of polychaete. Based on 96 h LC 50 values, polychaetes were exposed to sublethal doses of Cd. The concentrations for both subchronic and chronic assays were: 10; 30; 65; 310; 600; 1300; 2000; 4300 µgCd L −1 . The 96 h LC 50 value was 8234.9 µg L −1 , which was within the values reported for other species of polychaete, indicating a high tolerance to Cd. MT induction was not observed for any time exposure. In additoin, LPO levels showed no differences with respect to control levels, which indicated an absence of oxidative damage caused by Cd. However, the total Cd and MRG-Cd concentrations in L. acuta in all tested treatments showed significant differences with respect to control levels. L. acuta were able to accumulate Cd in their tissues in the form of granules which are the main mechanism of Cd detoxification. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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5. PANORÁMICA ACTUAL DE LOS CENTROS PÚBLICOS INTEGRADOS DE ENSEÑANZA OBLIGATORIA EN LA COMUNIDAD AUTÓNOMA DE GALICIA.
- Author
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Gerpe Pérez, Enelina María and Pérez Méndez, Luis Fernando
- Abstract
Copyright of Innovacion Educativa is the property of Universidad de Santiago de Compostela, Servicio de Publicaciones and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
6. Direct and inverse results for multipoint Hermite–Padé approximants
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Bosuwan, N., López Lagomasino, G., and Zaldivar Gerpe, Y.
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Given a system of functions $${\mathbf {f}}=(f_1,\ldots ,f_d)$$f=(f1,…,fd)analytic on a neighborhood of some compact subset Eof the complex plane with simply connected complement in the extended complex plane, we give necessary and sufficient conditions for the convergence with geometric rate of the common denominators of row sequences of multipoint Hermite–Padé approximants under a general extremal condition on the table of interpolation points. The exact rate of convergence of these denominators is provided and the rate of convergence of the simultaneous approximants is estimated. These results allow us to detect the location of the poles of the system of functions which are in some sense closest to E.
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- 2019
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7. Blood cadmium and metallothionein concentrations in females of two sympatric pinnipeds species.
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Polizzi, P., Romero, M.B., Chiodi Boudet, L.N., Ponce de León, A., Medici, S., Costas, A., Rodríguez, D., and Gerpe, M.
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OTARIA flavescens ,ARCTOCEPHALUS australis ,ERYTHROCYTES ,METALLOTHIONEIN ,BLOOD plasma - Abstract
Otaria flavescens (SASL) and Arctocephalus australis (SAFS) are endemic of South America. The aims were to assess Cd concentrations in red blood cells (RBC) and plasma from free living females of both species; and to establish metallothioneins (MT) levels in blood fractions and the possible relationship between MTs and Cd. Blood of fifteen SASL and eight SAFS females from Isla de Lobos were analyzed (years 2010–2011). All animals showed Cd levels above the detection limit. Cd concentrations on SAFS were higher than those of SASL, however, no significant differences were observed on metal concentrations between cell fractions by species. Metal levels were associated with a natural presence and ecological-trophic habits of the prey items. On SASL the MT concentrations between fractions were similar; whereas, SAFS plasma concentrations were higher than RBC. The results reported constitute the first information on Cd and MT blood levels in these species. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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8. Kiloniella majae sp. nov., isolated from spider crab (Maja brachydactyla) and pullet carpet shell clam (Venerupis pullastra).
- Author
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Gerpe, Diego, Buján, Noemí, Diéguez, Ana L., Lasa, Aide, and Romalde, Jesús L.
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SPIDER crabs ,VENERUPIS pullastra ,GRAM-negative bacteria ,REPRODUCTIVE isolation ,NUCLEOTIDE sequence ,BACTERIA phylogeny - Abstract
Ten Gram-negative, rod-shaped and motile bacterial strains were isolated from spider crab (M27.10, M27.11a, F36.1, F36.4, M56.1, F76.17b, M146.1, M166.3 and M166.6) and pullet carpet shell clam (SBRF 1.10) collected in the coast of Galicia. Analyses of the 16S rRNA genes showed that the strains belong to the genus Kiloniella and have high similarity with the species Kiloniella spongiae (99.44–99.86%) and Kiloniella litopenaei (99.0–99.5%). Strains M56.1 T (=CECT 9195, =LMG 29925), M146.1 (=CECT 9193, =LMG 29926) and SBRF 1.10 (=CECT 9194, =LMG 29927) were selected on the basis of genotyping by enterobacterial repetitive intergenic consensus PCR (ERIC-PCR). Phylogenetic analysis based on concatenated sequences of the genes gyrB , ftsZ , rpoD and mreB showed that the isolates form a differentiated branch within the genus Kiloniella. Moreover, the average nucleotide identity (ANIm, ANIb and OrthoANI) and in silico estimated DNA–DNA reassociation values between selected Galician isolates and Kiloniella species were below the established cut-off for species deliniation. The results obtained in the genetic and phenotypical analyses indicate that the isolates represent a new species of the genus Kiloniella , for which the name Kiloniella majae sp. nov. is proposed with strain M56.1 T (=CECT 9195 T , =LMG 29925 T ) as the type strain. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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9. The role of metallothioneins, selenium and transfer to offspring in mercury detoxification in Franciscana dolphins (Pontoporia blainvillei).
- Author
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Romero, M.B., Polizzi, P., Chiodi, L., Das, K., and Gerpe, M.
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MERCURY poisoning ,LA Plata dolphin ,METALLOTHIONEIN ,NEUROTOXICOLOGY ,ENDANGERED species ,STATISTICAL correlation - Abstract
The concentrations of mercury (Hg), selenium (Se) and metallothioneins (MT) were evaluated in fetuses, calves, juveniles and adults of the endangered coastal Franciscana dolphin ( Pontoporia blainvillei ) from Argentina. Mercury concentrations varied among analyzed tissues (liver, kidney, muscle and brain), with liver showing the higher concentrations in all specimens. An age-dependent accumulation was found in liver, kidney and brain. No significant relationship between Hg and MT concentrations was found for all tissues analyzed. Hepatic Hg molar concentrations were positively correlated with those of Se, indicating a great affinity between these two elements. Furthermore, dark granules of HgSe were observed in Kupffer cells in the liver by electron microscopy, suggesting the role of this macrophage in the detoxification of Hg. A transfer of Hg through placenta was proved. The presence of Hg in brain in all age classes did not show concentrations associated with neurotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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10. Hepatic and renal metallothionein concentrations in Commerson's dolphins (Cephalorhynchus commersonii) from Tierra del Fuego, South Atlantic Ocean.
- Author
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Cáceres-Saez, Iris, Polizzi, Paula, Romero, Belén, Dellabianca, Natalia A., Ribeiro Guevara, Sergio, Goodall, R. Natalie P., Cappozzo, H. Luis, and Gerpe, Marcela
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METALLOTHIONEIN ,CEPHALORHYNCHUS commersonii ,TOOTHED whales ,DOLPHINS ,MERCURY - Abstract
The Commerson's dolphin is the most common endemic odontocete of subantarctic waters of Tierra del Fuego, Argentina incidentally caught in fishing nets. The species is classified as “Data Deficient” by the IUCN. Metallothioneins (MTs) are considered as suitable biomarkers for health and environmental monitoring. The aims of the study were to assess MT concentrations in the liver and kidney of bycaught specimens. Moreover, correlations with Zn, Se, Cd, Ag and Hg, and the molar ratios of MT:metals were estimated to evaluate if there is an indication of their respective protective role against metal toxicity in tissues. Hepatic and renal MT concentrations were similar, ranging from 11.6 to 29.1 nmol·g − 1 WW, and Kidney/Liver ratios ranging from 0.73 to 1.93 corresponded to normal ranges. Results suggest that MTs are related to physiological ranges for the species. This information constitutes the first MT report on Commerson's dolphins and possibly considered as baseline for species' conservation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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11. Artificial light at night as a new threat to pollination
- Author
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Knop, Eva, Zoller, Leana, Ryser, Remo, Gerpe, Christopher, Hörler, Maurin, and Fontaine, Colin
- Abstract
Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens and climate change. Recently, the rapid global increase in artificial light at night has been proposed to be a new threat to terrestrial ecosystems; the consequences of this increase for ecosystem function are mostly unknown. Here we show that artificial light at night disrupts nocturnal pollination networks and has negative consequences for plant reproductive success. In artificially illuminated plant–pollinator communities, nocturnal visits to plants were reduced by 62% compared to dark areas. Notably, this resulted in an overall 13% reduction in fruit set of a focal plant even though the plant also received numerous visits by diurnal pollinators. Furthermore, by merging diurnal and nocturnal pollination sub-networks, we show that the structure of these combined networks tends to facilitate the spread of the negative consequences of disrupted nocturnal pollination to daytime pollinator communities. Our findings demonstrate that artificial light at night is a threat to pollination and that the negative effects of artificial light at night on nocturnal pollination are predicted to propagate to the diurnal community, thereby aggravating the decline of the diurnal community. We provide perspectives on the functioning of plant–pollinator communities, showing that nocturnal pollinators are not redundant to diurnal communities and increasing our understanding of the human-induced decline in pollinators and their ecosystem service.
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- 2017
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12. Histopathological and biochemical evidence of hepatopancreatic toxicity caused by cadmium in white shrimp, Palaemonetes argentinus.
- Author
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Chiodi Boudet, L.N., Polizzi, P., Romero, M.B., Robles, A., Marcovecchio, J.E., and Gerpe, M.S.
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HISTOPATHOLOGY ,BIOMARKERS ,PHYSIOLOGICAL effects of cadmium ,PALAEMONETES argentinus ,LIPID peroxidation (Biology) ,HEPATOTOXICOLOGY ,PANCREATIC analysis ,TOXICOLOGY of water pollution - Abstract
Cadmium (Cd) is one of the most common pollutants in the environment and induces a range of tissue changes or damages and organ dysfunction. The histopathological effects of Cd and lipid peroxidation (LPO) on hepatopancreas of the freshwater shrimp, Palaemonetes argentinus, were studied. Shrimp were obtained from two lagoons with contrasting environmental quality, De los Padres (LP, impacted site) and Nahuel Rucá (NR, reference site), and were exposed to 3.06 and 12.24 µg Cd L
−1 for 3, 7, 10 and 15 days. The health status of both populations was also evaluated by histological analysis of control individuals. After exposure, shrimp were transferred to clean water for 28 days to evaluate the recuperation capacity of hepatopancreas. Control shrimp from NR exhibited a normal hepatopancreas structure; unlike control shrimp from LP which showed several alterations. These results were attributed to the different environmental quality of lagoons. The exposure to Cd resulted in several alterations in the histological structure of the hepatopancreas of both populations. The observed alterations included haemocytic and connective infiltrations in the intertubular space, erosioned microvilli, ripple of basal lamina, atrophied epithelium and necrosis, however, the latter was only observed in shrimp from LP. The exposure also caused an increase of LPO levels in both populations. P. argentinus was able to repair the hepatopancreas structure from the damage caused by Cd, evidenced by the histopathological results and LPO levels. Obtained results are indicating that the histological analysis of the hepatopancreas proved to be a highly sensitive method for evaluating water quality, in both environmental and laboratory conditions. [ABSTRACT FROM AUTHOR]- Published
- 2015
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13. Solutions to improve the catching, handling and crating as part of the depopulation process of end of lay hens
- Author
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Gerpe, C. and Toscano, M.J.
- Abstract
The aim of our study was to investigate the effects of two interventions (i.e., two treatments across two independent experiments, each with its own control) that were thought to reduce fractures and stress related responses (e.g., changes in cloacal and comb temperature, respiration rate and tonic immobility [TI]) during the catching, handling and crating part of the depopulation process. In the cart treatment, hens were immediately crated instead of carrying them to the crating area in order to minimize handling time, stress and risk of injury to hens. The second intervention, the blue light treatment, used custom blue light modules with the aim of improving visibility for the workers in the barn, facilitating the catching and carrying process, leading to improved handling (e.g., fewer collisions with the pen furniture). The analysis revealed that neither the cart nor the blue light treatment effectively reduced fractures or stress related responses compared to the control. Possible explanations for the lack of findings include unfamiliarity with the work routine, unsuitable light intensity or orientation, and insufficient sample size. Despite the fact that the treatments failed to improve hen welfare in regards to the examined parameters, treatments may still improve working conditions as well as efficiency without negative effects on hen welfare. Whether a combination of the cart and blue light treatment and increased familiarity with the cart system would result in increased welfare of hens is unclear and should be the focus of future efforts.
- Published
- 2023
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14. Drowsiness Detection Based on the Analysis of Breathing Rate Obtained from Real-time Image Recognition
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Solaz, José, Laparra-Hernández, José, Bande, Daniel, Rodríguez, Noelia, Veleff, Sergio, Gerpe, José, and Medina, Enrique
- Abstract
Road accidents and victims provoked by drowsiness are a worldwide relevant social and economic problem. In EU, 25% of road accidents are related with fatigue. The relation between drowsiness and accidents is supported by scientific evidences that relate microsleep and other fatigue episodes with the loss of control of the vehicle. Nowadays there exist different technological approaches for drowsiness mitigating while driving, which try to reduce these accidents by detecting driver's physical condition and acting on the driver response. The techniques for mitigating accidents are based on algorithms of detection of physiological parameters that ensure drivers confidence and an appropriate use of the technology. The most frequently used non-invasive system are the cameras, which have been explored and used, mainly detecting eye movement and eyelid closure (PERCLOS). These systems have limitations due to artifacts and noise related to environmental and emotional conditions, which might lead to false positives. With the purpose of solving these shortcomings, the goal of the research is to develop a system capable of detecting the level of drowsiness based on the involuntary movements of the driver provoked by the respiration captured by means of cameras. In the current research, robustness in front of different types of users and circumstances has been explored. A system of reduced size automotive cameras of high dynamics is proposed to be used as breathing rate sensor. Images captured by these sensors will be processed to obtain the driver's chest/abdomen movement. These data will be analyzed in real time by a validated algorithm that interprets the movement and obtains the level of fatigue and drowsiness of the driver. A twofold “gold standard” is used to compare the robustness of the developed system. An experimental design has been developed in order to take into consideration different anthropometric characteristics, clothing types, user and vehicle movement and light conditions. The result will provide the boundary conditions of any system based on on-board cameras. These data will be used for building the algorithms to detect and interpret breathing patterns. The results show the capabilities of this approach and also permit to define the needs and requirements of the resulting technological developments.
- Published
- 2016
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15. Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina.
- Author
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Polizzi, P.S., Romero, M.B., Chiodi Boudet, L.N., Das, K., Denuncio, P.E., Rodríguez, D.H., and Gerpe, M.S.
- Subjects
LA Plata dolphin ,ONTOGENY ,FISH physiology ,ENVIRONMENTAL impact analysis ,METALS in the body - Abstract
Highlights: [•] This is the first report of MT concentrations in Franciscana dolphins. [•] Metal and MT levels were not associated to environmental impact. [•] MT levels correspond to physiological values according to ontogenetic changes. [•] Fetus presented higher levels of MT and essential metals than its mother. [•] There was a trend to decrease MT levels from early to later development stages. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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16. Fine scale distribution constrains cadmium accumulation rates in two geographical groups of Franciscana dolphin from Argentina.
- Author
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Polizzi, P.S., Chiodi Boudet, L.N., Romero, M.B., Denuncio, P.E., Rodríguez, D.H., and Gerpe, M.S.
- Subjects
LA Plata dolphin ,BIOACCUMULATION ,PHYSIOLOGICAL effects of cadmium ,MARINE ecology ,INFORMATION theory - Abstract
Highlights: [•] Fine scale distribution of two Argentine stocks constrains the Cd accumulation rates. [•] Cadmium levels and accumulation patterns were different between geographic groups. [•] Marine diet has a major influence than the impact degree of origin environment. [•] Engraulis anchoita is the main Cd vector species in Argentine shelf for Franciscana. [•] Information is valuable for the conservation of Franciscana, a vulnerable species. [Copyright &y& Elsevier]
- Published
- 2013
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17. Lethal and sublethal effects of cadmium in the white shrimp Palaemonetes argentinus: A comparison between populations from contaminated and reference sites.
- Author
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Chiodi Boudet, Leila, Polizzi, Paula, Romero, María Belén, Robles, Alicia, and Gerpe, Marcela
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PHYSIOLOGICAL effects of cadmium ,CADMIUM poisoning ,SHRIMPS ,WATER pollution ,BIOMARKERS ,METALLOTHIONEIN ,LIPID peroxidation (Biology) ,LAGOONS -- Environmental conditions ,PHYSIOLOGY - Abstract
In the present study, the acute toxicity of cadmium (Cd) in white shrimp (Palaemonetes argentinus) from a metal polluted lagoon (Los Padres, LP) and from unpolluted lagoon (Nahuel Ruca, NR) was evaluated. Both population, were exposed to 3.06, 12.26, 30.66, 61.32, 306 and 613.2μg Cd·L
−1 for 96-h. The sublethal effects of Cd were examined by two cellular biomarkers: metallothionein (MT) and lipid peroxidation (LPO). The seasonal variations of biomarkers in both lagoons were also evaluated. P. argentinus demonstrated a high sensitivity to Cd, with values of 96-h LC50 lower and close to those of highly sensitive species; therefore, can be proposed as a good indicator species. The LC50 values of shrimp from LP (24-h: 269.8, 48-h: 67.45, 72-h: 30.66, 96-h: 24.50μg Cd·L−1 ) were higher than those from NR (24-h: 153.3, 48-h: 32.65, 72-h: 18.40, 96-h: 12.26μg Cd·L−1 ), indicating a higher tolerance to Cd, and it was related to their origin. Differential responses in terms of MT induction and LPO between populations were also detected. In NR shrimps, the MT synthesis was induced very fast (24-h) and even at the minimum concentration tested (3.06μg Cd·L−1 ), while no increases were observed in LPO levels. In contrast, the MT and LPO levels in LP shrimps were not increased relative to control, although they were more tolerant to Cd than those of NR; suggesting the presence of another mechanism involved in the detoxification of Cd. The differences in both sensitivity and biochemical responses to Cd may be related with their environmental histories. [Copyright &y& Elsevier]- Published
- 2013
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18. Plastic ingestion in Franciscana dolphins, Pontoporia blainvillei (Gervais and d’Orbigny, 1844), from Argentina.
- Author
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Denuncio, Pablo, Bastida, Ricardo, Dassis, Mariela, Giardino, Gisela, Gerpe, Marcela, and Rodríguez, Diego
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PLASTIC scrap ,INGESTION ,LA Plata dolphin ,MARINE pollution ,GILLNETTING ,BIOACCUMULATION ,CETACEA - Abstract
Abstract: Plastic debris (PD) ingestion was examined in 106 Franciscana dolphins (Pontoporia blainvillei) incidentally captured in artisanal fisheries of the northern coast of Argentina. Twenty-eight percent of the dolphins presented PD in their stomach, but no ulcerations or obstructions were recorded in the digestive tracts. PD ingestion was more frequent in estuarine (34.6%) than in marine (19.2%) environments, but the type of debris was similar. Packaging debris (cellophane, bags, and bands) was found in 64.3% of the dolphins, with a lesser proportion (35.7%) ingesting fishery gear fragments (monofilament lines, ropes, and nets) or of unknown sources (25.0%). PD ingestion correlated with ontogenetic changes in feeding regimes, reaching maximum values in recently weaned dolphins. Because a simultaneous increase in gillnet entanglement and the bioaccumulation of heavy metals take place at this stage, the first months after trophic independence should be considered as a key phase for the conservation of Franciscana dolphin stocks in northern Argentina. [Copyright &y& Elsevier]
- Published
- 2011
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19. Arylethenylbenzofuroxan Derivatives as Drugs for Chagas Disease: Multigram Batch Synthesis using a Wittig−Boden Process.
- Author
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Williams Porcal, Alicia Merlino, Mariana Boiani, Alejandra Gerpe, Mercedes González, and Hugo Cerecetto
- Published
- 2008
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20. New Limonene-Hybrid Derivatives with Anti-T. cruzi Activity
- Author
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Alvarez, G., Gerpe, A., Benitez, D., Garibotto, F., Zacchino, S., Graebin, C. S., Gomes da Rosa, R., Eifler-Lima, V. L., Gonzalez, M., and Cerecetto, H.
- Abstract
The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycleframeworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5- nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives.
- Published
- 2010
21. Prematurely Aged Children: Molecular Alterations Leading to Hutchinson-Gilford Progeria and Werner Syndromes
- Author
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Dominguez-Gerpe, Lourdes and Araujo-Vilar, David
- Abstract
Ageing is thought to be a polygenic and stochastic process in which multiple mechanisms operate at the same time. At the level of the individual organism ageing is associated with a progressive deterioration of health and quality of life, sharing common features such as: alopecia and grey hair, loss of audition, macular degeneration, neurodegeneration, cardiovascular diseases, osteoporosis, cataract formation, type-2 diabetes, lipodystrophies; a generally increased susceptibility to infection, autoimmune disorders and diseases such as cancer; and an impaired ability to cope with stress. Recent studies of mechanisms involved in the ageing process are contributing to the identification of genes involved in longevity. Monogenic heritable disorders causing premature ageing, and animal models have contributed to the understanding of some of the characteristic organism-level features associated with human ageing. Werner syndrome and Hutchinson- Gilford progeria syndrome are the best characterized human disorders. Werner syndrome patients have a median life expectancy of 47 years with clinical conditions from the second decade of life. Hutchinson-Gilford progeria syndrome patients die at a median age of 11-13 years with clinical conditions appearing soon after birth. In both syndromes, alterations in specific genes have been identified, with mutations in the WRN and LMNA genes respectively being the most closely associated with each syndrome. Results from molecular studies strongly suggest an increase in DNA damage and cell senescence as the underlying mechanism of pathological premature ageing in these two human syndromes. The same general mechanism has also been observed in human cells undergoing the normal ageing process. In the present article the molecular mechanisms currently proposed for explaining these two syndromes, which may also partly explain the normal ageing process, are reviewed.
- Published
- 2008
22. Pharmacological Properties of Indazole Derivatives: Recent Developments
- Author
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Cerecetto, Hugo, Gerpe, Alejandra, Gonzalez, Mercedes, Aran, Vicente J., and de Ocariz, Carmen O.
- Abstract
The chemistry of indazole and its N-oxide derivatives is very well-known. Indazole derivatives were extensively studied as bioactive compounds, such as anti-aggregatory and vasorelaxant activity by NO release and increase of cGMP levels and anticancer effects, antimicrobial and antiparasitic properties, among others. Recently, the research and development in the medicinal chemistry of these systems have produced compounds with contraceptive activities for men, for the treatment of osteoporosis, inflammatory disorders and neurodegenerative diseases. On the other hand, indazole N-oxide derivatives were poorly studied as bioactive compounds, but recently compounds with antiparasitic properties were produced. In this presentation, recent developments in the chemistry and medicinal chemistry of indazole and its N-oxide derivatives will be reviewed.
- Published
- 2005
23. 2-Imidazolone Derivatives Obtained as Unexpected Products Throughout Imidazole N3-Oxide Rearrangement (Supplementary Material Available)
- Author
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Cerecetto, H., Gerpe, A., Gonzalez, M., Piro, O. E., and Castellano, E. E.
- Abstract
3-Alkyl(aryl)-2,3-dihydro-1H-2-imidazolone derivatives as unexpected product of the reaction between ethyl 3-alkyl(aryl)amino-2-oximinobutanoate and methyl orthoformate is described. These imidazolones are generated by an intramolecular attack and a migration of N3-oxide oxygen from the imidazole N3-oxide intermediates. This proposed mechanism is supported by the results of theoretical studies (DFT).
- Published
- 2005
24. Linking cadmium and mercury accumulation to nutritional intake in common dolphins (Delphinus delphis) from Patagonia, Argentina.
- Author
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Machovsky-Capuska, Gabriel E., von Haeften, Gabriela, Romero, M. Alejandra, Rodríguez, Diego H., and Gerpe, Marcela S.
- Subjects
MERCURY ,CADMIUM ,GASTROINTESTINAL content analysis ,DOLPHINS ,ANALYSIS of heavy metals ,METAL analysis ,HEAVY metals - Abstract
Bioaccumulation of Hg and Cd from food is a complex ecological process that has been oversimplified in the past. Common dolphins (Delphinus delphis) provide a powerful model to biomonitor metal concentrations in marine environments worldwide. We combined proportions-based nutritional geometry with metal analysis, stomach content analysis and the proximate composition of prey, to yield novel insights into the accumulation of Hg and Cd. Our analysis showed an age-related accumulation trend for Cd and Hg in kidney and liver, with highest concentrations found at 18 years of age. When viewed through the lens of nutritional ecology, Argentine anchovy (58.1 Mass %) and South American long-finned squid (22.7 Mass %), provided most of the dietary intake of protein (P) and lipids (L) (P:L ratio = 2.6:1.0) and also represented the main source for Cd and Hg levels accumulated in their bodies. This study presents unprecedented evidence on metal accumulation in relation to age and nutritional intake in a marine predator. Image 1 • Mercury and cadmium are non-essential metals that can be bioaccumulated. • Nutritional ecology can integrate metals and nutrients into a broader ecological context. • We demonstrate age-related accumulation trends for Cd in kidney and Hg in liver. • Engraulis anchoita and Loligo sanpaulensis mostly provided dietary protein, lipids, Cd and Hg. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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25. Modulation of stress-induced murine lymphoid tissue involution by age, sex and strain: role of bone marrow
- Author
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Dominguez-Gerpe, L. and Rey-Mendez, M.
- Published
- 1998
- Full Text
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26. Heavy metals in Antarctic organisms
- Author
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de Moreno, J. E. A., Gerpe, M. S., Moreno, V. J., and Vodopivez, C.
- Abstract
Abstract: To evaluate levels of essential (zinc and copper) and non-essential (mercury and cadmium) heavy metals, 34 species of organisms from different areas close to the Antarctic Peninsula were analysed. These included algae, filter-feeders, omnivorous invertebrates and vertebrates. Mercury was not detected, while cadmium was found in the majority of organisms analysed (detection limit was 0.05 ppm for both metals). The highest cadmium concentration was observed in the starfish Odontaster validus. Anthozoans, sipunculids and nudibranchs showed maximum levels of zinc, while the highest copper level was found in the gastropod Trophon brevispira. Mercury and cadmium levels in fishes were below the detection limit. Concentrations of essential and non-essential metals in birds were highest in liver followed by muscle and eggs. Cadmium and mercury levels in muscle of southern elephant seals were above the detection limit, whereas in Antarctic fur seals they were below it. The objective of the study was to gather baseline information for metals in Antarctic Ocean biota that may be needed to detect, measure and monitor future environmental changes.
- Published
- 1997
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27. Age-Related Changes in Primary and Secondary Immune Organs of the Mouse
- Author
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Domínguez-Gerpe, Lourdes and Rey-Méndez, Manuel
- Abstract
The present work describes the murine immune tissue evolution with age with special emphasis on the bone marrow. To that effect we monitored the weights of the thymus, spleen and axillary lymph nodes over the first year of life in C57BL/6 male and female mice. In addition, we monitored the relative proportions of erythroid, lymphoid and myeloid cells in the bone marrow, and performed in vitro migration assays of bone marrow cells to thymic supernatants, with the aim of determining whether the migration of such cells or the thymic attractive capacity are affected by age. Before puberty, a remarkable decline in the relative weight of the thymus, spleen and lymph nodes was observed; after that stage, however, only the thymus showed an involution. The proportion of myeloid cells in the bone marrow showed an increase with age. Furthermore, the migration of myeloid cells to thymic supernatants increased with age and paralleled the time-course of the myeloid cell increase found in the bone marrow. More interestingly, the proportion of lymphoid cells to total bone marrow cells showed a clear decline with age. The time-course of this decline closely paralleled that of thymus weight, suggesting that the involution of the thymus may be related to changes in the cell composition of the bone marrow.
- Published
- 1998
- Full Text
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28. Time-Course of the Murine Lymphoid Tissue Involution During and Following Stressor Exposure
- Author
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Dominguez-Gerpe, L. and Rey-Mendez, M.
- Published
- 1997
- Full Text
- View/download PDF
29. Lymphocyte protein synthesis: evidence that murine T cells are more affected by stress than B cells
- Author
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Dominguez-Gerpe, L. and Lefkovits, I.
- Published
- 1996
- Full Text
- View/download PDF
30. Examining the catching, carrying, and crating process during depopulation of end-of-lay hens
- Author
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Gerpe, C., Stratmann, A., Bruckmaier, R., and Toscano, M.J.
- Abstract
Laying hen flocks undergo depopulation at end of lay, a difficult process that has been associated with injuries and is considered stressful to hens and human collectors. To date, most assessments of depopulations have been conducted within cage housing systems, layers, or noncage broilers, thus offering little relevance to noncage laying hen systems including aviaries. Given that the predominant housing systems in Switzerland are multitier aviaries and their growing popularity in general, our study was undertaken to establish a baseline for hen injuries and stress as well as the experience of human workers during depopulation. For the effort, a total of 15 individual farms were visited, and a battery of assessments was made on a total of 603 individual end-of-lay hens. In addition, potentially influential factors such as time of day, handling duration, or time into depopulation were recorded and analyzed. The results suggest that approximately 8.1% of hens sustain severe injuries (i.e., fractures and muscle damage) or exhibit a considerable stress reaction (i.e., increased corticosterone levels), whereas 90% of laying hens are only mildly affected.
- Published
- 2021
- Full Text
- View/download PDF
31. Fusarium crookwellense-produced zearalenone in maize stubble in the field
- Author
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Lopez, T. A., Escande, A., Chayer, R., Dosanto, M., Gerpe, O., and Salomon, M. L.
- Abstract
Waste grain and vegetative material (stems and leaves) collected from a maize field several months after harvest was analysed by bi-dimensional thin layer chromatography for the presence of aflatoxins, deoxynivalenol, ochratoxin A, sterigmatocystin, T-2 toxin and zearalenone. Deoxinivalenol (0.7 mg/kg) and T-2 toxin (4.1 mg/kg) were found in the grain and zearalenone (3.0 mg/ kg) was found in the stem and leaf. No other toxins were detected. The stubble was examined for the presence of potentially toxigenic Fusarium species, and F. poae, F. moniliforme var. subglutinans and F. crookwellense were isolated and identified. When these isolates were cultured on cracked corn, only F. crookwellense was found to produce micotoxins and then only zearalenone was detected. As corn stubble is commonly grazed in Argentina and in other countries, these findings identify a further source of mycotoxins that may adversely affect animal health and productivity.
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- 1997
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32. Tissue distribution of heavy metals in small cetaceans from the southwestern Atlantic Ocean
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Bastida, Richard O., Gerpe, Marcela S., Marcovecchio, Jorge E., Moreno, Victor J., and Rodriguez, Diego H.
- Subjects
HEAVY metals - Published
- 1990
33. ChemInform Abstract: Naftifine‐Analogues as anti‐Trypanosoma cruzi Agents.
- Author
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Gerpe, Alejandra, Boiani, Lucia, Hernandez, Paola, Sortino, Maximiliano, Zacchino, Susana, Gonzalez, Mercedes, and Cerecetto, Hugo
- Abstract
The naftifine analogues are designed as potential T.cruzi membrane sterol biosynthesis inhibitors.
- Published
- 2010
- Full Text
- View/download PDF
34. ChemInform Abstract: Convenient Route to Primary (Z)‐Allyl Amines and Homologues.
- Author
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Gerpe, Alejandra, Bollini, Mariela, Gonzalez, Mercedes, and Cerecetto, Hugo
- Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
- Published
- 2009
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35. New Synthetic Approach for the Preparation of Imidazole N3‐Oxides.
- Author
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Cerecetto, Hugo, Gerpe, Alejandra, Gonzalez, Mercedes, Fernandez Saiz, Yolanda, Piro, Oscar E., and Castellano, Eduardo E.
- Abstract
For Abstract see ChemInform Abstract in Full Text.
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- 2005
- Full Text
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36. 78 RELACTATION
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Osorio, A., Ferrari, A. M., Acland, R., Ferrari, M. E., Suna, E., and Gerpe, L.
- Published
- 1981
37. 78 RELACTATION: A STUDY OF 100 MOTHERS AND THEIR INFANTS HOSPITALIZED FOR ACUTE DIARRHEA
- Author
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Osorio, A, Ferrari, A M, Acland, R, Ferrari, M E, Suna, E, and Gerpe, L
- Abstract
There exists data on the feasibility and need of reinduction of lactation. This is understood as a physiological process through which lactation is started again in women who have early weaned their children. As part of a program for joint mother and sick infant hospitalization, relactation was induced in 100 infants ages 6 months or less, which were hospitalized due to severe acute diarrhea with dehydratation, acidosis or shock. Weaning had been complete in 71 and partial in 29 infants. Relactation was based on the strong motivation of the mother, the family group and the health team, instalation of self demand breast feeding, progressive reduction of cow milk bottle feeding and caloric supplementation for the mother. Absolute relactation (only breast feeding) was obtained in 29 infants with an average duration of lactation of 55 days (range 7-150). Partial relactation (adding up to two bottles daily) was obtained in 23 infants with an average deration of 21 days (range 7-60).
- Published
- 1981
- Full Text
- View/download PDF
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