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New Limonene-Hybrid Derivatives with Anti-T. cruzi Activity
- Source :
- Letters in Drug Design & Discovery; July 2010, Vol. 7 Issue: 6 p452-460, 9p
- Publication Year :
- 2010
-
Abstract
- The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycleframeworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5- nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives.
Details
- Language :
- English
- ISSN :
- 15701808
- Volume :
- 7
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Letters in Drug Design & Discovery
- Publication Type :
- Periodical
- Accession number :
- ejs21818185