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2. Hydrological processes in the Aksu River source region during the intense ablation period based on water chemistry and isotopes

Author

Feng, Fang, Wu, Siqi, Feng, Qi, Jin, Shuang, Gou, Shusheng, and Huang, Qiaohua

Abstract

Against the backdrop of global warming, the dynamics of glaciers and their water resources have significant implications for hydrological processes in the arid regions of Northwest China. The Aksu River, which is an essential inland river enriched by substantial meltwater contributions, plays a pivotal role in the economic, ecological, and social development of the region. Based on 231 water samples collected during the period of intense glacial ablation in 2023, this study conducted a comprehensive analysis of the hydrochemical and stable isotopic characteristics of the Little Kurgan glacial basin in the Aksu River source region. A Piper diagram classified the hydrochemical type of the river water as Calcium–Bicarbonate. Analysis based on a Gibbs diagram indicated that rock weathering is the predominant factor affecting the hydrochemical properties within the studied basin. Through application of principal component analysis and end-member mixing analysis, it was determined that the glacier meltwater contribution to runoff was 67%, 61%, and 55% in July, August, and September, respectively. The findings of this study reveal that glacier meltwater is the principal component of the river water, and highlight the critical impact of alterations in glacier ablation on the hydrological cycle within the Aksu River source region, which is vitally important for sustainable water resource management.

Published
2024
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3. Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas

Author

Song, Pei-ran, Wan, Zhi-peng, Huang, Ge-ge, Song, Zi-lan, Zhang, Tao, Tong, Lin-jiang, Fang, Yan, Tang, Hao-tian, Xue, Yu, Zhan, Zheng-sheng, Feng, Fang, Li, Yan, Shi, Wen-hao, Huang, Yu-qing, Chen, Yi, Duan, Wen-hu, Ding, Jian, Zhang, Ao, and Xie, Hua

Abstract

Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK mutations facilitating evasion from BTK inhibition lead to resistance that limits the therapeutic efficacy of BTK inhibitors. In this study we employed structure-based drug design strategies based on established BTK inhibitors and yielded a series of BTK targeting compounds. Among them, compound S-016 bearing a unique tricyclic structure exhibited potent BTK kinase inhibitory activity with an IC50value of 0.5 nM, comparable to a commercially available BTK inhibitor ibrutinib (IC50= 0.4 nM). S-016, as a novel irreversible BTK inhibitor, displayed superior kinase selectivity compared to ibrutinib and significant therapeutic effects against B-cell lymphoma both in vitro and in vivo. Furthermore, we generated BTK inhibitor-resistant lymphoma cells harboring BTK C481F or A428D to explore strategies for overcoming resistance. Co-culture of these DLBCL cells with M0 macrophages led to the polarization of M0 macrophages toward the M2 phenotype, a process known to support tumor progression. Intriguingly, we demonstrated that SYHA1813, a compound targeting both VEGFR and CSF1R, effectively reshaped the tumor microenvironment (TME) and significantly overcame the acquired resistance to BTK inhibitors in both BTK-mutated and wild-type BTK DLBCL models by inhibiting angiogenesis and modulating macrophage polarization. Overall, this study not only promotes the development of new BTK inhibitors but also offers innovative treatment strategies for B-cell lymphomas, including those with BTK mutations.

Published
2024
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5. Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer

Author

Wang, Chaofan, Fang, Yan, Zhou, Ziqin, Liu, Zhuoheng, Feng, Fang, Wan, Xuan, Li, Yan, Liu, Shuang, Ding, Jian, Zhang, Zhi-Min, Xie, Hua, and Lu, Xiaoyun

Abstract

CCNE1amplification occurs in breast cancer and currently lacks effective therapies. PKMYT1 as a synthetic lethal target for CCNE1amplification holds promise for the treatment of CCNE1-amplified breast cancer. Herein, we discover a series of 2-amino-[1,1′-biphenyl]-3-carboxamide derivatives as potent and selective PKMYT1 inhibitors using structure-based drug design. The representative compound 8maexhibited excellent potency against PKMYT1, while sparing WEE1. It also suppressed proliferation of the CCNE1-amplified HCC1569 breast cancer cell line and showed synergistic cytotoxicity in combination with gemcitabine. PKMYT1 X-ray cocrystallography confirmed that introduction of key binding interactions between the inhibitors and residues Asp251 and Tyr121 of PKMYT1 greatly enhanced the potency and selectivity of the compounds.

Published
2024
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6. AM-DMF-SCP: Integrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip

Author

Yang, Zhicheng, Jin, Kai, Chen, Yimin, Liu, Qian, Chen, Hongxu, Hu, Siyi, Wang, Yuqiu, Pan, Zilu, Feng, Fang, Shi, Mude, Xie, Hua, Ma, Hanbin, and Zhou, Hu

Abstract

Single-cell proteomics offers unparalleled insights into cellular diversity and molecular mechanisms, enabling a deeper understanding of complex biological processes at the individual cell level. Here, we develop an integrated sample processing on an active-matrix digital microfluidic chip for single-cell proteomics (AM-DMF-SCP). Employing the AM-DMF-SCP approach and data-independent acquisition (DIA), we identify an average of 2258 protein groups in single HeLa cells within 15 min of the liquid chromatography gradient. We performed comparative analyses of three tumor cell lines: HeLa, A549, and HepG2, and machine learning was utilized to identify the unique features of these cell lines. Applying the AM-DMF-SCP to characterize the proteomes of a third-generation EGFR inhibitor, ASK120067-resistant cells (67R) and their parental NCI-H1975 cells, we observed a potential correlation between elevated VIM expression and 67R resistance, which is consistent with the findings from bulk sample analyses. These results suggest that AM-DMF-SCP is an automated, robust, and sensitive platform for single-cell proteomics and demonstrate the potential for providing valuable insights into cellular mechanisms.

Published
2024
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7. The application of a novel neural network in the detection of phishing websites

Author

Feng, Fang, Zhou, Qingguo, Shen, Zebang, Yang, Xuhui, Han, Lihong, and Wang, JinQiang

Abstract

In recent years, security incidents of website occur increasingly frequently, and this motivates us to study websites’ security. Although there are many phishing detection approaches to detect phishing websites, the detection accuracy has not been desirable. In this paper, we propose a novel phishing detection model based on a novel neural network classification method. This detection model can achieve high accu-racy and has good generalization ability by design risk minimization principle. Furthermore, the training process of the novel detection model is simple and stable by Monte Carlo algorithm. Based on testing of a set of phishing and benign websites, we have noted that this novel phishing detection model achieves the best Accuracy, True-positive rate(TPR), False-positive rate(FPR), Precision, Recall, F-measureand Matthews Correlation Coefficient(MCC)comparable to other models as Naive Bayes (NB), Logistic Regression(LR), K-Nearest Neighbor (KNN), Decision Tree (DT), Linear Support Vector Machine (LSVM), Radial-Basis Support Vector Machine (RSVM) and Linear Discriminant Analysis (LDA). Furthermore, based upon experiments, we find that the proposed detection model can achieve a high Accuracyof 97.71% and a low FPRof 1.7%. It indicates that the proposed detection model is promising and can be effectively applied to phishing detection.

Published
2024
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8. Electroacupuncture on Baihui (DU20) and Xuehai (SP10) acupoints alleviates psoriatic inflammation by regulating neurotransmitter substance P- Neurokinin-1 receptor signaling

Author

Qi, Cong, Feng, Fang, Guo, JianNing, Liu, Yu, Guo, XiaoYao, Meng, YuJiao, Di, TingTing, Hu, XueQing, Wang, Yazhuo, Zhao, Ning, Zhang, XiaWei, Wang, Yan, Zhao, Jingxia, and Li, Ping

Abstract

At present, acupuncture-related practices have been widely used to treat psoriasis. In our study, we investigated the effect and explored the mechanism of electroacupuncture (EA) on acupoints Baihui (DU20) and Xuehai (SP10) for the treatment of psoriasis.

Published
2024
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9. Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma.

Author

Liu, Yingqiang, Zhan, Zhengsheng, Kang, Zhuang, Li, Mengyuan, Lv, Yongcong, Li, Shenglan, Tong, Linjiang, Feng, Fang, Li, Yan, Zhang, Mengge, Xue, Yaping, Chen, Yi, Zhang, Tao, Song, Peiran, Su, Yi, Shen, Yanyan, Sun, Yiming, Yang, Xinying, Yao, Shanyan, and Yang, Hanyu

Subjects
BLOOD-brain barrier, BRAIN tumors, GLIOBLASTOMA multiforme, GLIOMAS, ANTINEOPLASTIC agents, METHYLGUANINE
Abstract

Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults and is poorly controlled. Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression, and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment. Therefore, this study developed a novel and selective inhibitor of CSF1R and VEGFR, SYHA1813, possessing potent antitumor activity against GBM. SYHA1813 inhibited VEGFR and CSF1R kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo. SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models, including temozolomide (TMZ) insensitive tumors. Notably, SYHA1813 could penetrate the blood–brain barrier (BBB) and prolong the survival time of mice bearing intracranial GBM xenografts. Moreover, SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody. As a clinical proof of concept, SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial. The data of this study support the rationale for an ongoing phase I clinical study (ChiCTR2100045380). SYHA1813 exerts anti-tumor effects by simultaneously inhibiting angiogenesis and affecting tumor-associated macrophages, and shows the therapeutic potential of glioma by efficiently crossing the blood–brain barrier. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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13. Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor

Author

Li, Qian, Zhang, Tao, Song, Peiran, Tong, Linjiang, Feng, Fang, Guo, Jing, Zhou, Yang, Xie, Hua, and Lu, Xiaoyun

Abstract

Activated Cdc42-associated kinase 1 (ACK1) alterations have been considered to mediate bypass acquired resistance to the third-generation EGFR inhibitors (ASK120067 and osimertinib) in NSCLC. Despite many efforts to develop ACK1 small molecule inhibitors, no selective inhibitors have entered clinical trials. We used structure-based drug design to obtain a series of (R)-8-((tetrahydrofuran-2-yl)methyl)pyrido [2,3-d]pyrimidin-7-ones as novel selective ACK1 inhibitors. One of the representative compounds, 10zi, potently inhibited ACK1 kinase with an IC50of 2.1 nM,while sparing SRC kinase (IC50= 218.7 nM). Further, 10zidisplayed good kinome selectivity in a profiling of 468 kinases. In the ASK120067-resistant lung cancer cell line (67R), 10zidose-dependently inhibited the phosphorylation of ACK1 and downstream AKT pathway and showed a strong synergistic anti-tumor effect in combination with ASK120067 in vitro. Additionally, 10zialso exhibited reasonable PK profiles with an oral bioavailability of 19.8% at the dose of 10 mg/kg, which provided a promising lead for further development of new anticancer drugs.

Published
2023
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14. Layer-by-Layer Microneedle-Mediated rhEGF Transdermal Delivery for Enhanced Wound Epidermal Regeneration and Angiogenesis

Author

Yuan, Renqiang, Yang, Ning, Huang, Yueru, Li, Weikun, Zeng, Yi, Liu, Zonghao, Tan, Xin, Feng, Fang, Zhang, Qianli, Su, Shao, Chu, Cuilin, Liu, Ling, and Ge, Liqin

Abstract

Appropriate treatments for acute traumas tend to avoid hemorrhages, vascular damage, and infections. However, in the homeostasis-imbalanced wound microenvironment, currently developed therapies could not precisely and controllably deliver biomacromolecular drugs, which are confronted with challenges due to large molecular weight, poor biomembrane permeability, low dosage, rapid degradation, and bioactivity loss. To conquer this, we construct a simple and effective layer-by-layer (LBL) self-assembly transdermal delivery patch, bearing microneedles (MN) coated with recombinant human epidermal growth factor (LBL MN-rhEGF) for a sustained release to wound bed driven by typical electrostatic force. Pyramidal LBL MN-rhEGF patches hold so enough mechanical strength to penetrate the stratum corneum, and generated microchannels allow rhEGF direct delivery in situ. The administrable delivery of biomacromolecular rhEGF through hierarchically coated MN arrays follows the diffusion mechanism of Fick’s second law. Numerous efforts further have illustrated that finger-pressing LBL MN-rhEGF patches could not only promote cell proliferation of normal human dermal fibroblasts (NHDF) and human umbilical vein endothelial cells (HUVEC) in vitrobut also take significant effects (regenerative epidermis: ∼144 μm; pro-angiogenesis: higher CD31 expression) in accelerating wound healing of mechanically injured rats, compared to the traditional dressing, which relies on passive diffusion. Our proof-of-concept features novel LBL biomacromolecular drug-delivery systems and self-administrated precision medicine modes at the point of care.

Published
2023
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15. Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial

Author

Reynolds, Harmony R., Page, Courtney B., Shaw, Leslee J., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Kwong, Raymond Y., Min, James K., Leipsic, Jonathon, Mancini, G.B. John, Budoff, Matthew J., Hague, Cameron J., Senior, Roxy, Szwed, Hanna, Bhargava, Balram, Celutkiene, Jelena, Gadkari, Milind, Bainey, Kevin R., Doerr, Rolf, Ramos, Ruben B., Ong, Peter, Naik, Sudhir R., Steg, Philippe Gabriel, Goetschalckx, Kaatje, Chow, Benjamin J.W., Scherrer-Crosbie, Marielle, Phillips, Lawrence, Mark, Daniel B., Spertus, John A., Alexander, Karen P., O’Brien, Sean M., Boden, William E., Bangalore, Sripal, Stone, Gregg W., Maron, David J., Hochman, Judith S., Mavromatis, Kreton, Linefsky, Jason, Miller, Todd, Banerjee, Subhash, Newman, Jonathan D., Donnino, Robert M., Saric, Muhamed, Abdul-Nour, Khaled, Stone, Peter H., Jang, James J., Yee, Gennie, Weitz, Steven, Arnold, Suzanne, James Henry, O’Keefe, Shapiro, Michael D., Fein, Steven A., Torosoff, Mikhail T., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Siddiqui, Rizwan A., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Goldberg, Jonathan L., Goldweit, Richard, Cohen, Ronny A., Mirrer, Brooks, Navarro, Victor, Winchester, David E., Kronenberg, Marvin, McFarren, Christopher, Heitner, John F., Dauber, Ira M., Cannan, Charles, Sudarshan, Sriram, Mehta, Puja K., McDaniel, Michael, Lerakis, Stamatios, Quyyumi, Arshed, Wenger, Nanette K., Hedgepeth, Chester M., Hurlburt, Heather, Rosen, Alan, Sahul, Zakir, Leung, Steve, Reda, Hassan, Ziada, Khaled, Setty, Sampoornima, Barua, Rajat S., Hage, Fadi, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, El-Hajjar, Mohammad, Der Mesropian, Paul, Sacco, Joseph, McCandless, Brian, Orgera, Marisa, Sidhu, Mandeep S., Arif, Imran, Kerr, Hanan, Trejo (Gutierrez), Jorge F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, O'Rourke, Daniel, Meadows, Judith L., Call, Jason T., Hannan, Joseph, Bojar, Robert, Kumar, Deepti, Mukai, John, Martin, Edward T., Vorobiof, Gabriel, Moorman, Alec, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Bhatt, Deepak L., Croce, Kevin, Quin, Jacquelyn A., Anumpa, Jati, Zenati, Marco, Faxon, David P., Rayos, Glenn, Seedhom, Ashraf, Sullenberger, Lance, Kumkumian, Gregory, Sedlis, Steven P., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Kornberg, Robert, Leber, Robert, Saba, Souheil, Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Marzo, Kevin, Robbins, Inga H., Levite, Howard A., Shetty, Sanjay, Patel, Mayuri, Hamroff, Glenn S., Little, Raymond W., Zimbelman, Brandi D., Lui, Charles Y., Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Kotter, John, Abdel-Latif, Ahmed, Hu, Bob, Labovitz, Arthur J., Berlowitz, Michael, Rogal, Philip, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Schnittger, Ingela, Fearon, William F., Deedwania, Prakash, Reddy, Kiran, Sweeny, Joseph, Spizzieri, Christopher, Hochberg, Claudia P., Salerno, William D., Wyman, Ray, Zarka, Amer, Shah, Anil V., Haldis, Thomas, Kohn, Jeffrey A., Girotra, Saket, Almousalli, Omar, Krishnam, Mayil S., Milliken, Jeffrey C., Patel, Pranav M., Seto, Arnold H., Harley, Kevin T., Gibson, Michael A., Allen, Byron J., Coram, Rita, Thomas, Sabu, Schwartz, Ronald G., Chen, Wei, El Shahawy, Mahfouz, Stafford, James, Abernethy, William B., Zurick, Andrew, Meyer, Thomas M., Morford, Ronald G., Rutkin, Bruce, Bokhari, Sabahat, Sokol, Seth I., Meisner, Jay, Hamzeh, Ihab, Misra, Arunima, Matthew, Wall, De Rosen, Veronica Lenges, Alam, Mahboob, Turner, Michael C., Mulhearn, Thomas J., Good, Arnold P., Shammas, Nicolas W., Chilton, Robert, Nguyen, Patricia K., Jezior, Matthew, Gordon, Paul C., Crain, Thomas, Stenberg, Robert, Pedalino, Ronald P., Wiesel, Joseph, Juang, George J., Al-Amoodi, Mohammed, Wohns, David, Lader, Ellis W., Mumma, Michael, Dharmarajan, Lekshmi, Joseph F.X., McGarvey, Downes, Thomas R., Luckasen, Gary J., Cheong, Benjamin, Potluri, Srinivasa, Mastouri, Ronald A., Breall, Jeffery A., Revtyak, George E., Bazeley, Jonathan W., Li, Dayuan, Giedd, Kenneth, Old, Wayne, Burt, Francis, Sokhon, Kozhaya, Gopal, Deepika, Valeti, Uma S., Kobashigawa, Jon, Chakanalil Govindan, Sajeev, Gopalan Nair, Rajesh, Nanjappa Manjunath, Cholenahally, Moorthy, Nagaraja, Cholenahally Manjunath, Satvic, Narayanappa, Suryaprakash, Pandit, Neeraj, Kumar Nath, Ranjit, Dwivedi, S.K., Narain, V.S., Chandra, Sharad, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Aslam, Naved, Goyal, Abhishek, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V.K., Mathew, Anoop, Punnoose, Eapen, Gadage, Siddharth, Umesh Pillay, Tapan, Satheesh, Santhosh, Mathur, Atul, Christopher, Johann, Menon, Rajeev, Kumar, Nirmal, Oomman, Abraham, Mao, Robert, Solomon, Hilda, Parveen Khan, Sajeeda, Grant, Purvez, Kachru, Ranjan, VK, Ajit Kumar, Ganapathi, Sanjay, K., Jayakumar, Sivadasanpillai, Harikrishnan, Sasidharan, Bijulal, T.R., Kapilamoorthy, Polamuri, Praneeth, Kaul, Upendra, Fox, Keith A.A., Carruthers, Kathryn, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Shah, Benoy N., Trimlett, Richard H.J., Rubens, Michael B., Nicol, Edward D., Mittal, Tarun K., Hampson, Reinette, Andreas Gamma, Reto, de Belder, Mark A., Thambyrajah, Jeet, Nageh, Thuraia, Davies, John R., Lindsay, Steven J., Kurian, John, Jamil, Haqeel, Raheem, Osama, Hoye, Angela, Donnelly, Patrick, Valec ka, Bernardas, Chauhan, Anoop, Barr, Craig, Alfakih, Khaled, Byrne, Jonathan, Webb, Ian, Henriksen, Peter, O. Kane, Peter, de Silva, Ramesh, Conway, Dwayne S.G., Sirker, Alexander A., Hoole, Stephen P., Witherow, Fraser N., Johnston, Nicola, Harbinson, Mark, Walsh, Simon, Douglas, Hanna, Luckie, Matthew, Sobolewska, Jolanta, Jeetley, Paramjit, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Karimullah, Iqbal, Al-Bustami, Mahmud, Braganza, Denise, Henderson, Robert, Pointon, Kate, Naik, Surendra, Mathew, Thomas, Berry, Colin, Collison, Damien, Roditi, Giles, Moriarty, Andrew J., Glover, Jason D., Pradhan, Jiwan, Ghada, Mikhail, Francis, Darrel P., Dzavik, Vladimir, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Pépin-Dubois, Yanek, Costa, Ricardo, Tung Sia, Ying, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Carl Phaneuf, Denis, Gosselin, Gilbert, Garg, Pallav, Hessian, Renee C., Beanlands, Rob S., Davies, Richard F., Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Graham, John Joseph, Peterson, Mark, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Tariq Vakani, Mohammad, Cha, James, Howarth, Andrew G., Wong, Graham, Uxa, Amar, Galiwango, Paul, Kassam, Saleem, Mukherjee, Ashok, Joseph Ricci, A., Lam, Andy, Me, Shamir, Udell, Jacob, Généreux, Philippe, Hameed, Adnan, Daba, Ledjalem, Hueb, Whady, Cury Rezende, Paulo, Ciappina Hueb, Alexandre, Emanuela, Paola, Smanio, Poggio, Schaan de Quadros, Alexandre, Abdala, Renato, Kalil, Karam, da Costa Vieira, José Luiz, Grossmann, Gabriel, Píccaro de Oliveira, Pedro, Bridi, Leonardo, Savaris, Simone, Vitola, João V., Cerci, Rodrigo J., Farias, Fabio R., Fernandes, Miguel M., Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Mendes Oliveira, Ricardo, Reynaldo, João, Chierice, Abbud, Polanczyk, Carísi A., Furtado, Mariana V., Smidt, Luis F., Carlos Carvalho, Antonio, Pucci, Gustavo, Lyra, Flavio, Rabelo, Alvaro, Junior, Alves, Dracoulakis, Marianna D.A., Lima, Rodolfo G.S.D., Figueiredo, Estevao, Ricardo Caramori, Paulo, Tumelero, Rogerio, Dall’Orto, Frederico, Mesquita, Claudio T., Colafranseschi, Alexandre S., Amarino C., Oliveira, Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., da Silva, Expedito Eustáquio Ribeiro, Gabriel, Pedro, de Barros e Silva, Melo, de Pádua Silva Baptista, Luciana, Jamus Rodrigues, Marcelo, de Resende, Marcos Valério Coimbra, Francisco Saraiva, Jose, Costantini, Costantino, Ruzyllo, Witold, Demkow, Marcin, Pracon, Radoslaw, Kepka, Cezary, Teresinska, Anna, Kryczka, Karolina, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Fratczak, Aleksandra, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Roik, Marek, Łoboz-Grudzień, Krystyna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Bockeria, Leo, Petrosyan, Karen, Trifonova, Tatiana, Chernyavskiy, Alexander M., Kretov, Evgeniy I., Grazhdankin, Igor O., Bershtein, Leonid L., Sayganov, Sergey A., Kuzmina-Krutetskaya, Anastasia M., Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Demchenko, Elena A., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Lopez-Sendon, Jose, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Cuenca-Castillo, José J., Flores-Ríos, Xacobe, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Diez, Jose L., Calvillo, Pilar, Marin Ortuño, F., Valdés Chávarri, M., Tello Montolliu, A., Pinar Bermudez, E., De La Morena, G., Gracida Blancas, Montserrat, Enrique Castillo Luena, Jose, Fernandez-Aviles, Francisco, Chen, Jiyan, Wu, Yongjian, Ma, Yitong, Yang, Yining, Ji, Zheng, Yang, Xinchun, Lin, Wenhua, Zeng, Hesong, Fu, Xin, Wang, Songtao, Cheng, Gong, Zhao, Yulan, Fang, Xuehua, Zeng, Qiutang, Su, Xi, Li, Qingxian, Nie, Shao-Ping, Yu, Qin, Wang, Jian'an, Zhang, Shuyang, Liu, Zhenyu, Maggioni, Aldo P., Piero Perna, Gian, Marini, Marco, Gabrielli, Gabriele, Provasoli, Stefano, Verna, Edoardo, Monti, Lorenzo, Nardi, Barbara, Di Chiara, Antonio, Mortara, Andrea, Galvani, Marcello, Ottani, Filippo, Sicuro, Marco, Calabro, Paolo, Formisano, Tiziana, Tarantini, Giuseppe, Cucchini, Umberto, Luigi Andres, Anto, Racca, Emanuela, Briguori, Carlo, Amati, Roberto, Vergoni, William, Russo, Aldo, Fanelli, Raffaele, Poh, Kian-Keong, Chai, Ping, Lau, Titus, Loh, Joshua P., Tay, Edgar L., Teoh, Kristine, Teo, Lynette L., Ong, Ching-Ching, Wong, Raymond C., Loh, Poay-Huan, Kofidis, Theodoros, Xian Chan, Wan, Hui Chan, Koo, Foo, David, Loh Kwok Kong, Jason, Ching, Min, Haider Jafary, Fahim, Chua, Terrance, Stumpf, Juergen, Matschke, Klaus, Simonis, Gregor, Kadalie, Clemens T., Sechtem, Udo, Christian Schulze, P., Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Schuchlenz, Herwig, Weikl, Stefan, Marthe Lang, Irene, Huber, Kurt, Jakl-Kotauschek, Gabriele, Keltai, Matyas, Vertes, Andras, Varga, Albert, Fontos, Geza, Merkely, Bela, Kerecsen, Gabor, Hinic, Sasa, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Petrovic, Marija T., Dobric, Milan R., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic-Adjic, Nada, Davidović, Goran, Vučić, Rada, Nikola Dekleva, Milica, Stankovic, Goran, Apostolovic, Svetlana, Escobedo, Jorge, Baleón-Espinosa, Rubén, Campos-Santaolalla, Arturo S., Durán-Cortés, Elihú, Flores-Palacios, José M., García-Rincón, Andrés, Jiménez-Santos, Moisés, Peñafiel, Joaquín V., Ortega-Ramírez, José A., Valdespino-Estrada, Aquiles, Alexánderson Rosas, Erick, Murphy, Deirdre, Selvanayagam, Joseph B., Joseph, Majo X., Thambar, Suku T., Rankin, Jamie, Beltrame, John F., Hillis, Graham S., Thuaire, Christophe, Dutoiu, Téodora, Juliard, Jean-Michel, Slama, Michel S., El Mahmoud, Rami, Nicollet, Eric, Goube, Pascal, Barone-Rochette, Gilles, Furber, Alain, Bière, Loïc, Laucevicius, Aleksandras, Kedhi, Elvin, MD, Timmer, Jorik, Hermanides, Rik, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, van Dongen, Elise, Niehe, Sander R., Suryapranata, Harry, van Vugt, Stijn, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Bernanrdes, Luis, Rio, Pedro, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Nobre Menezes, Miguel, Cantinho Lopes, Guilhermina, Gomes Almeida, Ana, Canas Silva, Pedro, Nobre, Angelo, Rita Francisco, Ana, Ferreira, Nuno, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, César Figal, Julio, Méndiz, Oscar, Cortés, Claudia, René Favaloro, Roberto, Alvarez, Carlos, Courtis, Javier, Zeballos, Gabriela, Schiavi, Lilia, Rubio, Mariano, Alsweiler, Caroline, Patrick Devlin, Gerard, Fisher, Raewyn, Alan Huston Stewart, Ralph, Douglas White, Harvey, Benatar, Jocelyne, Kedev, Sasko, Peovska Mitevska, Irena, Srbinovska Kostovska, Elizabeta, Pejkov, Hristo, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Johnston, Nina, Olsowka, Maciej, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Beyar, Rafael, Nikolsky, Eugenia, Sharir, Tali, Elian, Dan, Kerner, Arthur, Massalha, Samia, Fukuda, Keiichi, Kohsaka, Shun, Yasuda, Satoshi, Nishimura, Shigeyuki, Van de Werf, Frans, Claes, Kathleen, Hung, Chung-Lieh, Yun, Chun-Ho, Jia-Yin Hou, Charles, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Viljoen, Charle A., De Andrade, Marianne, Moccetti, Tiziano, Grazia Rossi, M., Abdelhamid, Magdy, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, El Kaffas, Sameh, El Fishawy, Hussien, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Deleanu, Dan, Iliescu, Vlad A., Al-Mallah, Mouaz H., Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Ramos, Walter Enrique Mogrovejo, Kuanprasert, Srun, Prommintikul, Arintaya, Nawarawong, Weerachai, Woragidpoonpol, Surin, Tepsuwan, Thitipong, Taksaudom, Noppon, Rimsukcharoenchai, Chataroon, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, Khairuddin, Ahmad, Abd Hadi, Hafidz, Azmi Yahaya, Shaiful, Doan, John, Lee, Raven, Patel, Risha, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Kamath, Preeti, Tejani, Ishita, Quiles, Kirsten J., Schley, Allison, Golden, Heather, Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Anaya, Olivia, Goold, Phoebe, Giovannone, Steven, Pritchard, Lori, Gans Paul Kennedy, Rosann, Ganesan, Shobana, Schlichting, David, Naher, Aynun, Stewart, Wendy L., Salmi, Kristin M., Johnson, Debra K., Herrmann, Rebekah R., Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Ann Byrne, Kimberly, Zappernick, Taissa, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Stinson, Susan, Weyand, Terry, Crook, Sherron C., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Desire, Sukie, Rashid, Fauzia, Asier, Senait, Patel, Keyur, Gillis, Jennifer, Manocchia, Megan, Moore, Susan, Congdon, Elizabeth, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Valaiyapathi, Badhma, Kartje, Carol M., Rawlins, Michele, Thomson, Jennifer, Colleen Rogge, Mary, Bunke, Julie, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Dubin, Marcia F., Beaudry, Sarah, Tirado, Stephanie A., Halliday, Janet, Julian, Pamela, Stephanie, Lane, M., Stanford, Jennifer L., Arsenault, Patricia, Sigel, Pamela, Brooks, Miriam, Douangvila, Ladda, Gevorgyan, Rubine, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Ly, Samantha, Quinn, Margot C., Temiyasathit, Sara, Do, Jacquelyn, Tobin, Desiree, Langdon, Jennifer, Werner Bayer, Marcia, O'Malley, Amanda, Orvis, Erin, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Maranan, Leandro C., Malinay, Ammy, Edillo, Candice P., Ostrander, Ann, Wasmiller, Stephanie, Drewes, Wendy, Patel, Dipti, White, Jackie M., Hallam, Alison, Spooner, Benjamin J., Hollenweger, Linda M., Little, Holly, Little, Tiffany, Eskelson, Nona A., Taul, Yvonne, Rodgers, Caroline, Isaacs, Jennifer, Bulkley, Viktoria, Kaneshiro, Renee, Kirby, Bonnie J., Tran, Nhi N., Jahrsdorfer, Catherine, Yunis, Reem, Patro, Jhina, Vega, Antonia, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Schade, Danielle, Yost, Roxanne, Beardsley, Paula, Fine, Denise, Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, O'Neill, Deborah, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Aguirre, Maria, Dhawan, Manu, Parra, Diana, Tran, Tri, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Quiles, Kirsten J., Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Heydari, Shirin, Lundeen, Andrea M., Karanjah, Edgar, Marfori, Wanda C., Hernandez-Rangel, Eduardo, Singh, Pam, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Kim, Angela, Wilmot, Patrick, Stevens, Ramona, Black, Loriane, Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Horton, Hollie, Orga, Jan, White, Joyce R., Baumann, Cynthia, Seeratan, Vidya, Jimenez, Magnolia, Schultz, Cidney, Russo, Jeanne, Huda, Zohra, Boan, Araceli, Hinton, Christine R., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Gail A., Christensen, Lori, Park, Holly, Hecht, Joan, Vo, Davis, Hirsch, James, Bindeman, Jody, Salkind, Sara, Desimone, Lori-Ann, Felix-Stern, Lina, Gomes, Jassira, Gordon, Catherine, Mann, Aimee, McCreary, Theresa, Quiles, Kirsten J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Mulder, Abbey, Van Oosterhout, Stacie, Meyer, Martha, Clapp, Nancy L., Barrentine, Heather, Jose, Jenne M., Manchery, Jenne, McKinney, Vera, Schwarz, Linda, Kaczkowski, Scott M., Jaskowiak, Adam J., Klitch, Joel, Dees, Debra, Vasquez, Precilia, Hannemann, Elise L., Mae Foltz, Judy, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Bariciano, Rebecca, Waldron, Jessica, Mayon, Michelle, Ann Peichel, Gretchen, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Anand, Anjali, Raj, Janitha, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Bajaj, Sheromani, Yadav, Vandana, Mishra, Girish, Tewari, Roma, Mishra, Meenakshi, Patel, Shivali, Singh, Suman, Kaur, Baljeet, Gupta, Sonika, Suvarna, Chandini, Mannekkattukudy Kurian, Binoy, Rupesh Karwa, Sheetal, Kolhe, Suvarna, Vindhya, R.J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Verma, Atul, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Manjula Rani, K., Sowjanya Reddy, M., Preethi, K., Sidh, Rinu R., Priya, Vamshi, Preethi, Kotiboinna, Hande, Shweta, Dubey, Abhishek, Rawat, Kavita, Vineeth, CP, Chacko, Manas, Babu, Suresh, Reddy, Sowjanya, Rani, Manjula, Arambam, Priyadarshani, Singh, Bebek, Young, Grace M., Kinsey, Christopher, Kavalakkat, Raisa, Evans, Jo, Hassan, Ikraam, Williams, Sarah, Holland, Kim, Swan, Karen, Atkinson, Bev, Kunhunny, Swapna, Atkinson, Craig, Krannila, Carita, Vinod, Manitha, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Kelly, Stephanie, Regan, Susan, Turnbull, Dawn, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Cartwright, Anne, Knightonc, Abigail, Martin, Katherine, Flint, Laura, Harrison, James, Lakeman, Nicki, Ljubez, Anja, Wright, Judith, Exley, Donna, Andiapen, Mervyn, Richards, Amy J., Wong, Lisa, Munro, Melanie J., McEvoy, Michelle, Brown, Caroline, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Smit, Angelique, Gent, Susan, Hussain, Nafisa, Haines, Fiona, Taaffe, Joanne, Burton, Jane, Colton, Maria, King, Rachel, Brown, Ammani, Docherty, Andrew, McCloy, Lisa, Robb, Kate, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Mackin, Anne, Knight, Janet P., Bose, Tuhina, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Alarie, Patricia, Arcand, Linda, Roy, Isabelle, Montpetit, Estelle, Drouin, Katia, Bergeron, Christine, Shelley, Christine, Masson, Christine, Carr, Sandy, Bone, Catherine, Moga, Ermina, Kourzenkova, Janetta, Walter, Olga, Hogg, Norma, Welsh, Suzanne, Hussain, Mohammed, Bello, Olugbenga, Syed, Ishba, Kushniriuk, Khrystyna, Otis, Judy, Otis, Rebecca, Seib, Michelle M., Rivest, Sandra M., Sandonato, Rosa, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Asif, Nadia, Tavares, Suzana, Bozek, Bev, Shier, Maria, Larmand, Lori-Ann, Janmohamed, Amir, Hart, Brenda, Marucci, Jane, Tai, Sharon, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Aprile, Maria, Karlsson, Sara, Webber, Susan, Mercure, Chantale, Aedy, Nancy, Farquharson, Fran, Siddiqui, Anam, Emy Takiuti, Myrthes, Pizzol Caetano, Leonardo, Peixoto Deiro, Aline, Manica Muller, Alice, de Moraes, Maria Antonieta Pereira, Maria Ascoli, Bruna, Zottis Poletti, Sílvia, Zier, Sandra S., Veiga, Vilmar, Franca da Cunha, Diego, Rucatti, Guilherme G., Igansi, Fernanda, Haeffner, Mauren P., Almeida, Viviane, Sanchez de Souza, Gabriela, Almeida, Mayana, dos Santos, Viviane, Oliveira, Natalia S., Edilena Paulino Azevedo, Bruna, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Laimer, Rosane, Tognon, Alexandre, Santos, Roberta P., Yumi Okada, Mariana, Paula Batista, Ana, Nogueira Rabaça, Aline, Miranda Trama, Larissa, Silva, Talita, de Souza Ormundo, Camila Thais, Vicente, Carla, Pinheiro, Caroline, Komar, Daniele, Walesiak, Olga, Malinowska, Katarzyna, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Swiderek, Marta, Wojtala, Ewelina, Karwowski, Jaroslaw, Łabyk, Andrzej, Szramowska, Agnieszka, Zdończyk, Olga, Jaroch, Joanna, Kolodziej, Adam, Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Kudzoeva, Zalina, Aripova, Nodira, Naryshkin, Ivan A., Kuleshova, Alena, Malaev, Dastan, Subbotina, Irina, Gumerova, Victoria, Nikolaeva, Olga B., Fernández-Figares, Virginia, Pharm, Blanco-Calvo, Moisés, Alonso-Álvarez, Encarnación, García-González, Paula, Seijas Amigo, Jose, Fernández Martínez, Ana, Igual, Begoña, Romero Aniorte, M. Quintana Giner A.I., Rivera Caravaca, J.M., Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Lasala, Maria, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Tian, Yanmeng, Li, Dongze, Li, Xiaomei, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Jing, Rui, Liu, Jingjing, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, Bin, Yue, Zhou, Zhang, Zhulin, Dong, Yumei, Mao, Jiajia, Zhang, Bin, Li, Xiuhong, Yao, Xiaowei, Zhong, Nier, Zhou, Ning, Huang, Yaping, Zhou, Panpan, Wei, Kunwu, Yu, Peng, Yudong, Su, Xin, Wang, Chen, Zhao, Yunhai, Geng, Yaming, Wang, Yanfu, Fan, Jing-Yao, Feng, Si-Ting, Wang, Xiao, Yan, Yan, Zhang, Hui-Min, Chi, Lingping, Liu, Fang, Chen, Han, Jiang, Jun, Li, Huajun, Han, Yechen, Xu, Lihong, Chen, Gang, Hu, Rongrong, Pietrucci, Francesca, Di Donato, Anna, Pezzetta, Francesca, Casali, Valentina, Attanasio, Chiara, Leone, Gianpiero, Pisano, Francesco, Bare, Cristina, Fimiani, Fabio, Barioli, Alberto, Ramani, Federica, Rolfo, Fabrizio, Goletto, Cecilia, De Micco, Francesca, Di Marco, Stefano, Tricoli, Martina, Villella, Massimo, Tan, Sik-Yin V., Sia, Winnie C., Leong, Audrey W., Hai Yan, Li, Ismail, Nasrul, Tun Kyaw, Min, Yip, Deborah, Grahl, Dorit, Guenther, Franziska, Bonin, Kerstin, Wenzelburger, Ina, Gruensfelder, Susanne, Sinning, Jan-Malte, Weber, Marcel, Werner, Nikos, Steinmaurer, Gudrun, Winter, Max-Paul, Tijana, Andric, Tscharre, Maximilian, Claudia, Bernhard, Wegmayrc, Jäger, Egger, Floria, Sebo, Judit, Davidovits, Zoltan, Matics, Laszlone, Ágoston, Gergely, Dekany, Gabor, Bartykowszki, Andrea, Jakal, Agnes, Djokic, Jelena, Djordjevic-Dikic, Ana D., Giga, Vojislav L., Stepanovic, Jelena J., Velicki, Lazar, Pupic, Ljiljana, Simović, Stefan M., Stevo Martinovic, Miroslav, Stevanovic, Gordana, Dobric, Milan, Salinger Martinovic, Sonja, Stanojevic, Dragana, de Jesús-Pérez, Ramon, Brassetti, María Fernanda Canales, Adrián Vences Anaya, Diego, Pérez García, María, Estela Carvajal Juarez, Isabel, Madero Rovalo, Magdalena, Lee, Sau, Thomas, Prince, Chaplin, Melissa D., Stansborough, Jeanette K., Black, Marilyn, Bonner, Michelle M., Ireland, Kim F., Venn-Edmonds, Clare, Thobois, Corine, Tachot, Emilie, Laure, Christophe, Vassaliere, Christel, Abergel, Helene, Fuentes, Axelle, Eliahou, Ludivine, Dubourg, Olivier, Michaud, Pierre, Hadjih, Sarah, Brito, Patricia, Cornet, Charles, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laukyte, Monika, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Bouwhuis, Ilse, Nijmeijer, Lia, Jeannette, Elisabeth, J.M. Schoep, Janzen, M., Ahoud, Sandra, Selas, Mafalda, Silva, Filipa, Freixo, Cláudia, Zimbarra Cabrita, Inês, Rocha, Andreia, Patuleia Figueiras, Francisca, Coelho, Andreia, Capinha, Marta, Inês Caetano, Maria, Silva, Susana, Tinnirello, Veronica, Nicolás Mungo, Matías, Garcia, Marina, Godoy, Valeria, Victoria Actis, Maria, Scaro, Graciela, Low, Liz, Scales, Jayne, Abercrombie, Kirsty, Howell, Leah, Patten, Cathrine, Björklund, Christina, Andreasson, Maria, Essermark, Marie, Persson, Liselotte, Harel, Or, Bentzvi, Margalit, Helmer, Ludmila, Ueda, Ikuko, Fujita, Jun, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nakano, Shintaro, Robesyn, Valerie, Yang, Yi-Hsuan, Mtana, Noloyiso, Anesini, Adriana, Maspoli, Simona, Mombelli, Manuela, Talaat, Ahmed, Rosca, Monica, Beladan, Carmen C., Zahrani, Sarah, Antonio Monsalve Davila, Marco, Khwakhong, Supatchara, Chaiyasri, Anong, Mekara, Warangkana, Kulthawong, Supap, Amaritakomol, Anong, Panpunuan, Pachara, Syamira Mokhtar, Noor, Asiah Basri, Nor, Yusnida, Irni, Hashim, Humayrah, Berger, Jeffrey, Williams, David, Harrington, Robert, Jiang, Lixin, Lopes, Renato D., Noel Bairey Merz, C., Weintraub, William, Donato Morales Rodríguez, Erick, Maurovich-Horvat, Pal, Sonawane, Poonam, Francis, Rajesh, Ramakrishnan, T., Nayak, Soundarya, Boer, Stephanie C., Rosenberg, Yves, Hamm, Christian, Helm, Malte, Peterson, Eric, Ballantyne, Christie, Calfas, Karen, Ann Champagne, Mary, Fleg, Jerome, McCullough, Peter A., Menasche, Philippe, Davidson, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, de Bruyne, Bernard, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Mahaffey, Ken, Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Friedrich, Matthias, Hachamovitch, Rory, Oliver, Dana, Harrel, Frank, Blume, Jeffrey, Lee, Kerry, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Cohen, David, Bugiardini, Raffaele, Mattina, Deirdre, Ali, Ziad, Mathew, Roy, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Michael Gibson, C., Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Nwosu, Samuel, Kirby, Ruth, Jeffries, Neal, Denaro, Jean E., Boumakis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Van Loo, Kerrie, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne D., Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, David Knight, J., Minshall Liu, Diane, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Jingyan Wang, Grace, Goyal, Abhinav, Hetrick, Holly, Hayes, Sean W., Friedman, John D., Mark Hyun, R. James Gerlach, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Pierre Mongeon, Francois, Michael, Steven, Hung, Judy, Zeng, Xin, Eckstein, Jane, Guruge, Bandula, Streif, Mary, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Arsanjani, Reza, Elmor, Kimberly, Gomez, Millie, Hindoyan, Niree, Nakanishi, Rine, Barbara Srichai-Parsia, M., Yeoh, Eunice, Youn, Tricia, Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Mazza Barbosa, Lilian, Bello Duarte, Tauane, Colaiácovo Soares, Tamara, de Aveiro Morata, Julia, Carvalho, Pedro, de Carvalho Maffei, Natalia, Egydio, Flávia, Kawak, Anelise, Oliveira, Janaina, Restelli Piloto, Elissa, Pozzibon, Jaqueline, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Escobar, Claudia, Eugenia Martin, Maria, Pascual, Andrea, Moraga, Paloma, Hernandez, Victoria, Posada, Maria, Fernandez, Sara, Luis Narro Villanueva, José, Selgas, Rafael, Luyten, Ann, Garcevic, Nevena, Stojkovic, Jelena, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, Siddaram, Hemalata, and Kedhi, Elvin

Published
2024
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16. Hexavalent chromium removal by green synthesized nano-size iron particles combined with iron sulfides: Effects of dissolved oxygen and phosphate.

Author

Gao, Weidong, Chen, Haijun, Ma, Xinyue, Xu, Nan, Feng, Fang, and Zhang, Shan

Subjects
IRON sulfides, HEXAVALENT chromium, HYBRID systems, HYBRID materials, IRON, OXYGEN, CHROMIUM compounds
Abstract

The removal of hexavalent chromium (Cr(VI)) from wastewater using the green synthesized nano-zero-valent-iron (GnZVI) has attracted great attention. However, the Cr(VI) removal capacity of GnZVI remains limited by dissolved oxygen (DO) or phosphate in wastewater. Therefore, Cr(VI) removal by GnZVI combined with iron sulfides (i.e., FeS or FeS 2) impacting by DO and phosphate was investigated at pH 2.0 and 6.0. Experimental results showed that DO inhibited the Cr(VI) removal by GnZVI with FeS at pH 2.0, because high DO saturation was beneficial to Fe(II) oxidization into Fe(III). Nevertheless, DO promoted the corrosion and dissolution of FeS 2 but GnZVI for Cr(VI) reduction at pH 2.0. Especially, phosphate inhibited the Cr(VI) reduction by the combination of GnZVI and iron sulfides at pH 2.0, likely because phosphate inhibited Fe(II) release from GnZVI hybrid materials during the reduction process from Cr(VI) to Cr (III). Differently, at pH 6.0, phosphate mainly promoted Cr(VI) removal by FeS compared with GnZVI via the formation of phosphate complexation, while it inhibited Cr(VI) removal using GnZVI combined with FeS 2 through the competitive adsorption. This study reveals the potential inherent mechanisms and emphasizes a sustainable strategy for the effective removal of Cr(VI) using a hybrid technique that combines GnZVI and iron sulfides under complex wastewater conditions. [Display omitted] • DO inhibited Cr(VI) reduction of GnZVI and FeS via transform Fe(II) into Fe(III). • DO promoted Cr(VI) reduction of FeS 2 but GnZVI via increasing Fe(II) dissolution. • P inhibited Fe(II) release from GnZVI hybrid system for Cr(VI) reduction at pH 2.0. • P promoted Cr(VI) reduction of FeS because of phosphate complexation at pH 6.0. • P inhibited Cr(VI) removal by GnZVI combined with FeS 2 at pH 6.0. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Radical 1,5-Chloropentafluorosulfanylation of Unactivated Vinylcyclopropanes and Transformation into α-SF5Ketones

Author

Feng, Fang-Fang, Ma, Jun-An, and Cahard, Dominique

Abstract

The radical 1,5-chloropentafluorosulfanylation of vinyl cyclopropanes (VCPs) initiated by Et3B/O2affords allylic pentafluorosulfanyl/homoallylic chloride products through the ring-strain release of the cyclopropane. The VCP substitution pattern was investigated. The utility of this reaction was illustrated in post-transformation of the C═C bond by ozonolysis, giving access to valuable α-SF5carbonyl compounds.

Published
2021
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21. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial

Author

Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. John, Boden, William E., Newman, Jonathan D., Reynolds, Harmony R., Hochman, Judith S., Maron, David J., Doan, John, Linefsky, Jason, Lee, Raven, Patel, Risha, Miller, Todd, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Banerjee, Subhash, Kamath, Preeti, Tejani, Ishita, Cobos, Stanley E., Quiles, Kirsten J., Dwyer, Raven R., Donnino, Robert M., Espinosa, Dalisa, Phillips, Lawrence M., Saric, Muhamed, Abdul-Nour, Khaled, Schley, Allison, Golden, Heather, Stone, Peter H., Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Jang, James J., Anaya, Olivia, Yee, Gennie, Goold, Phoebe, Weitz, Steven, Giovannone, Steven, Pritchard, Lori, Arnold, Suzanne, Gans, Rosann, Henry O’Keefe, James, Jr, Kennedy, Paul, Shapiro, Michael D., Ganesan, Shobana, Schlichting, David, Naher, Aynun, El-Hajjar, Mohammad, Sidhu, Mandeep S., Fein, Steven A., Stewart, Wendy L., Torosoff, Mikhail T., Salmi, Kristin M., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Johnson, Debra K., Siddiqui, Rizwan A., Herrmann, Rebekah R., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Goldberg, Jonathan L., Ann Byrne, Kimberly, Zappernick, Taissa, Goldweit, Richard, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Cohen, Ronny A., Espinosa, Dalisa, Mirrer, Brooks, Quiles, Kirsten J., Navarro, Victor, Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Winchester, David E., Stinson, Susan, Kronenberg, Marvin, Weyand, Terry, Rogal, Philip, Crook, Sherron C., McFarren, Christopher, Heitner, John F., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Dauber, Ira M., Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Siegel, Kathy E., Derbyshire, Susan, Cannan, Charles, Dixon, Michelle, Leonard, Gerald, Sudarshan, Sriram, Heard, Ciarra, Gabriel, Viviana, Desire, Sukie, Mehta, Puja K., McDaniel, Michael, Rashid, Fauzia, Lerakis, Stamatios, Asier, Senait, Quyyumi, Arshed, Patel, Keyur, Wenger, Nanette K., Hedgepeth, Chester M., Gillis, Jennifer, Hurlburt, Heather, Manocchia, Megan, Rosen, Alan, Moore, Susan, Congdon, Elizabeth, Sahul, Zakir, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Booth, David, Taul, Yvonne, Leung, Steve, Isaacs, Jennifer, Abdel-Latif, Ahmed, Bulkley, Viktoria, Reda, Hassan, Rodgers, Caroline, Ziada, Khaled, Setty, Sampoornima, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Barua, Rajat S., Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Hage, Fadi, Valaiyapathi, Badhma, Caldeira, Christiano, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, Kartje, Carol M., El-Hajjar, Mohammad, Mesropian, Paul Der, Sacco, Joseph, Rawlins, Michele, McCandless, Brian, Thomson, Jennifer, Orgera, Marisa, Sidhu, Mandeep S., Colleen Rogge, Mary, Arif, Imran, Bunke, Julie, Kerr, Hanan, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Trejo, Jorge F., Dubin, Marcia F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, Beaudry, Sarah, O’Rourke, Daniel, Meadows, Judith L., Tirado, Stephanie A., Halliday, Janet, Julian, Pamela, Call, Jason T., Stephanie, Lane, M., Stanford, Jennifer L., Hannan, Joseph, Bojar, Robert, Arsenault, Patricia, Kumar, Deepti, Sigel, Pamela, Mukai, John, Martin, Edward T., Brooks, Miriam, Vorobiof, Gabriel, Douangvila, Ladda, Gevorgyan, Rubine, Moorman, Alec, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Ly, Samantha, Bhatt, Deepak L., Quinn, Margot C., Croce, Kevin, Temiyasathit, Sara, Quin, Jacquelyn A, Do, Jacquelyn, Anumpa, Jati, Tobin, Desiree, Zenati, Marco, Faxon, David P, Rayos, Glenn, Langdon, Jennifer, Werner Bayer, Marcia, Seedhom, Ashraf, O’Malley, Amanda, Sullenberger, Lance, Orvis, Erin, Kumkumian, Gregory, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Sedlis, Steven P., Maranan, Leandro C., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Malinay, Ammy, Kornberg, Robert, Leber, Robert, Saba, Souheil, Edillo, Candice P., Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Ostrander, Ann, Wasmiller, Stephanie, Marzo, Kevin, Drewes, Wendy, Patel, Dipti, Robbins, Inga H., Levite, Howard A., White, Jackie M, Shetty, Sanjay, Hallam, Alison, Patel, Mayuri, Hamroff, Glenn S., Spooner, Benjamin J, Hollenweger, Linda M, Little, Raymond W., Little, Holly, Zimbelman, Brandi D., Little, Tiffany, Lui, Charles Y., Eskelson, Nona A, Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Taul, Yvonne, Kotter, John, Rodgers, Caroline, Abdel-Latif, Ahmed, Isaacs, Jennifer, Bulkley, Viktoria, Hu, Bob, Kaneshiro, Renee, Labovitz, Arthur J., Berlowitz, Michael, Kirby, Bonnie J., Rogal, Philip, Tran, Nhi N., McFarren, Christopher, Jahrsdorfer, Catherine, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Yunis, Reem, Schnittger, Ingela, Patro, Jhina, Fearon, William F., Deedwania, Prakash, Vega, Antonia, Reddy, Kiran, Sweeny, Joseph, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Spizzieri, Christopher, Schade, Danielle, Yost, Roxanne, Hochberg, Claudia P, Beardsley, Paula, Fine, Denise, Salerno, William D., Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, O’Neill, Deborah, Wyman, Ray, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Zarka, Amer, Aguirre, Maria, Shah, Anil V., Dhawan, Manu, Parra, Diana, Tran, Tri, Haldis, Thomas, Weick, Catherine, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Kohn, Jeffrey A., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Girotra, Saket, Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Almousalli, Omar, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Krishnam, Mayil S., Heydari, Shirin, Milliken, Jeffrey C., Lundeen, Andrea M., Patel, Pranav M., Karanjah, Edgar, Seto, Arnold H., Marfori, Wanda C., Harley, Kevin T., Hernandez-Rangel, Eduardo, Gibson, Michael A., Singh, Pam, Allen, Byron J., Coram, Rita, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Thomas, Sabu, Kim, Angela, Schwartz, Ronald G, Wilmot, Patrick, Chen, Wei, El Shahawy, Mahfouz, Stevens, Ramona, Stafford, James, Black, Loriane, Abernethy, William B., Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Zurick, Andrew, Horton, Hollie, Orga, Jan, Meyer, Thomas M., White, Joyce R., Morford, Ronald G., Baumann, Cynthia, Rutkin, Bruce, Seeratan, Vidya, Bokhari, Sabahat, Jimenez, Magnolia, Sokol, Seth I., Schultz, Cidney, Meisner, Jay, Russo, Jeanne, Hamzeh, Ihab, Misra, 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Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Wohns, David, Mulder, Abbey, Van Oosterhout, Stacie, Lader, Ellis W., Meyer, Martha, Mumma, Michael, Clapp, Nancy L., Barrentine, Heather, Dharmarajan, Lekshmi, Jose, Jenne M., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Manchery, Jenne, McGarvey Jr, Joseph F.X., McKinney, Vera, Schwarz, Linda, Downes, Thomas R., Kaczkowski, Scott M., Luckasen, Gary J., Jaskowiak, Adam J., Klitch, Joel, Cheong, Benjamin, Dees, Debra, Potluri, Srinivasa, Vasquez, Precilia, Mastouri, Ronald A., Breall, Jeffery A., Hannemann, Elise L., Revtyak, George E., Mae Foltz, Judy, Bazeley, Jonathan W., Li, Dayuan, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Giedd, Kenneth, Old, Wayne, Bariciano, Rebecca, Burt, Francis, Sokhon, Kozhaya, Waldron, Jessica, Mayon, Michelle, Gopal, Deepika, Valeti, Uma S., Ann Peichel, Gretchen, Kobashigawa, Jon, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Bhargava, Balram, Anand, Anjali, Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, Santhosh, Vindhya, R. J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Mathur, Atul, Verma, Atul, Kaul, Upendra, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Christopher, Johann, Manjula Rani, K., Menon, Rajeev, Sowjanya Reddy, M., Kumar, Nirmal, Preethi, K., Oomman, Abraham, sidh, Rinu R, Mao, Robert, Ramakrishnan, T., Solomon, Hilda, Francis, Rajesh, Naik, Sudhir, Vamshi, Priya P., Parveen Khan, Sajeeda, Christopher, Johann, Preethi, Kotiboinna, Kumar, Nirmal, Grant, Purvez, Hande, Shweta, Sonawane, Poonam, Kachru, Ranjan, Dubey, Abhishek, Rawat, Kavita, Kumar, Ajit, Ganapathi, Sanjay, K, Jayakumar, CP, Vineeth, Sivadasanpillai, Harikrishnan, Chacko, Manas, Sasidharan, Bijulal, Babu, Suresh, TR, Kapilamoorthy, Christopher, Johann, Reddy, Sowjanya, Polamuri, Praneeth, Rani, Manjula, Kaul, Upendra, Arambam, Priyadarshani, Singh, Bebek, Senior, Roxy, Fox, Keith AA, Young, Grace M., Carruthers, Kathryn, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Young, Grace M., Shah, Benoy N, Kinsey, Christopher, Trimlett, Richard HJ, Kavalakkat, Raisa, Rubens, Michael B, Evans, Jo, Nicol, Edward D, Hassan, Ikraam, Mittal, Tarun K, Hampson, Reinette, Andreas Gamma, Reto, Williams, Sarah, Holland, Kim, Swan, Karen, de Belder, Mark A, Atkinson, Bev, Thambyrajah, Jeet, Kunhunny, Swapna, Davies, John R, Lindsay, Steven J., Atkinson, Craig, Kurian, John, Krannila, Carita, Jamil, Haqeel, Vinod, Manitha, Raheem, Osama, Hoye, Angela, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Donnelly, Patrick, Kelly, Stephanie, Valecka, Bernardas, Regan, Susan, Turnbull, Dawn, Chauhan, Anoop, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Barr, Craig, Cartwright, Anne, Alfakih, Khaled, Knighton, Abigail, Byrne, Jonathan, Martin, Katherine, Webb, Ian, Henriksen, Peter, Flint, Laura, Harrison, James, OKane, Peter, Lakeman, Nicki, Ljubez, Anja, de Silva, Ramesh, Conway, Dwayne S. G., Wright, Judith, Exley, Donna, Sirker, Alexander A, Andiapen, Mervyn, Richards, Amy J., Hoole, Stephen P, Wong, Lisa, Witherow, Fraser N., Munro, Melanie J., Johnston, Nicola, Harbinson, Mark, McEvoy, Michelle, Walsh, Simon, Brown, Caroline, Douglas, Hanna, Luckie, Matthew, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Sobolewska, Jolanta, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Jeetley, Paramjit, Smit, Angelique, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Gent, Susan, Karimullah, Iqbal, Hussain, Nafisa, Al-Bustami, Mahmud, Braganza, Denise, Haines, Fiona, Taaffe, Joanne, Henderson, Robert, Burton, Jane, Pointon, Kate, Colton, Maria, Naik, Surendra, King, Rachel, Mathew, Thomas, Brown, Ammani, Docherty, Andrew, Berry, Colin, McCloy, Lisa, Collison, Damien, Robb, Kate, Roditi, Giles, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Moriarty, Andrew J, Mackin, Anne, Glover, Jason D., Knight, Janet P, Pradhan, Jiwan, Mikhail, Ghada, Bose, Tuhina, Francis, Darrel P., Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Gosselin, Gilbert, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Alarie, Patricia, Pépin-Dubois, Yanek, Arcand, Linda, Costa, Ricardo, Roy, Isabelle, Tung Sia, Ying, Montpetit, Estelle, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Drouin, Katia, Carl Phaneuf, Denis, Bergeron, Christine, Gosselin, Gilbert, Shelley, Christine, Masson, Christine, Garg, Pallav, Carr, Sandy, Bone, Catherine, Chow, Benjamin J.W., Moga, Ermina, Hessian, Renee C., Kourzenkova, Janetta, Beanlands, Rob S., Walter, Olga, Davies, Richard F., Bainey, Kevin R., Hogg, Norma, Welsh, Suzanne, Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Kushniriuk, Khrystyna, Joseph Graham, John, Hussain, Mohammed, Peterson, Mark, Bello, Olugbenga, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Syed, Ishba, Hussain, Mohammed, Kushniriuk, Khrystyna, Cha, James, Otis, Judy, Otis, Rebecca, Howarth, Andrew G, Seib, Michelle M, Rivest, Sandra M, Sandonato, Rosa, Wong, Graham, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Uxa, Amar, Asif, Nadia, Tavares, Suzana, Galiwango, Paul, Bozek, Bev, Kassam, Saleem, Shier, Maria, Mukherjee, Ashok, Larmand, Lori-Ann, Ricci, A. Joseph, Janmohamed, Amir, Hart, Brenda, Lam, Andy, Marucci, Jane, Tai, Sharon, Mehta, Shamir, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Udell, Jacob, Aprile, Maria, Karlsson, Sara, Webber, Susan, Généreux, Philippe, Mercure, Chantale, Hameed, Adnan, Aedy, Nancy, Daba, Ledjalem, Farquharson, Fran, Siddiqui, Anam, Carlos Carvalho, Antonio, Lopes, Renato D., Hueb, Whady, Emy Takiuti, Myrthes, Cury Rezende, Paulo, Eustáquio Ribeiro Silva, Expedito, Ciappina Hueb, Alexandre, Pizzol Caetano, Leonardo, Schaan de Quadros, Alexandre, Abdala Karam Kalil, Renato, Peixoto Deiro, Aline, Luiz da Costa Vieira, José, Manica Muller, Alice, Antonieta Pereira de Moraes, Maria, Píccaro de Oliveira, Pedro, Maria Ascoli, Bruna, Bridi, Leonardo, Zottis Poletti, Sílvia, Savaris, Simone, Vitola, João V, Cerci, Rodrigo J, Zier, Sandra S., Farias, Fabio R, Veiga Jr, Vilmar, Fernandes, Miguel M, Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Franca da Cunha, Diego, Mendes Oliveira, Ricardo, Reynaldo Abbud Chierice, João, Polanczyk, Carísi A., Rucatti, Guilherme G, Furtado, Mariana V., Igansi, Fernanda, Smidt, Luis F., Haeffner, Mauren P, Carlos Carvalho, Antonio, Almeida, Viviane, Pucci, Gustavo, Sanchez de Souza, Gabriela, Lyra, Flavio, Rabelo Alves Junior, Alvaro, Almeida, Mayana, dos Santos, Viviane, Dracoulakis, Marianna D. A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira Jr., Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, Bin, Yue, Zhou, Zhang, Zhulin, Wang, Songtao, Dong, Yumei, Mao, Jiajia, Zhang, Bin, Cheng, Gong, Li, Xiuhong, Yao, Xiaowei, Zhong, Nier, Zhou, Ning, Zhao, Yulan, Huang, Yaping, Zhou, Panpan, Fang, Xuehua, Su, Wei, Zeng, Qiutang, Kunwu, Yu, Peng, Yudong, Su, Xin, Su, Xi, Wang, Chen, Zhao, Yunhai, Li, Qingxian, Geng, Yaming, Wang, Yanfu, Nie, Shao-ping, Fan, Jing-yao, Feng, Si-ting, Wang, Xiao, Yan, Yan, Zhang, Hui-min, Yu, Qin, Chi, Lingping, Liu, Fang, Wang, Jian’an, Chen, Han, Jiang, Jun, Li, Huajun, Wang, Jian’an, Han, Yechen, Xu, Lihong, Zhang, Shuyang, Liu, Zhenyu, Liu, Zhenyu, Chen, Gang, Hu, Rongrong, Maggioni, Aldo P., Piero Perna, Gian, Pietrucci, Francesca, Marini, Marco, Gabrielli, Gabriele, Provasoli, Stefano, Di Donato, Anna, Verna, Edoardo, Monti, Lorenzo, Nardi, Barbara, Di Chiara, Antonio, Pezzetta, Francesca, Mortara, Andrea, Casali, Valentina, Galvani, Marcello, Attanasio, Chiara, Ottani, Filippo, Sicuro, Marco, Leone, Gianpiero, Pisano, Francesco, Bare, Cristina, Calabro, Paolo, Fimiani, Fabio, Formisano, Tiziana, Tarantini, Giuseppe, Barioli, Alberto, Cucchini, Umberto, Ramani, Federica, Luigi Andres, Anto, Racca, Emanuela, Rolfo, Fabrizio, Goletto, Cecilia, Briguori, Carlo, De Micco, Francesca, Amati, Roberto, Di Marco, Stefano, Vergoni, William, Tricoli, Martina, Russo, Aldo, Villella, Massimo, Fanelli, Raffaele, Douglas White, Harvey, Alsweiler, Caroline, Poh, Kian-Keong, Chai, Ping, Lau, Titus, Loh, Joshua P., Tay, Edgar L., Teoh, Kristine, Tan, Sik-Yin V, Teo, Lynette L., Sia, Winnie C, Ong, Ching-Ching, Leong, Audrey W, Wong, Raymond C., Loh, Poay-Huan, Kofidis, Theodoros, Xian Chan, Wan, Hui Chan, Koo, Foo, David, Hai Yan, Li, Loh Kwok Kong, Jason, Min Er, Ching, Haider Jafary, Fahim, Chua, Terrance, Ismail, Nasrul, Tun Kyaw, Min, Yip, Deborah, Doerr, Rolf, Doerr, Rolf, Stumpf, Juergen, Grahl, Dorit, Matschke, Klaus, Guenther, Franziska, Simonis, Gregor, Bonin, Kerstin, Kadalie, Clemens T., Sechtem, Udo, Wenzelburger, Ina, Ong, Peter, Gruensfelder, Susanne, Christian Schulze, P., Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Sinning, Jan-Malte, Weber, Marcel, Werner, Nikos, Marthe Lang, Irene, Huber, Kurt, Schuchlenz, Herwig, Steinmaurer, Gudrun, Weikl, Stefan, Marthe Lang, Irene, Winter, Max-Paul, Andric, Tijana, Huber, Kurt, Tscharre, Maximilian, Jakl-Kotauschek, Gabriele, Wegmayr, Claudia, Jäger, Bernhard, Egger, Florian, Keltai, Matyas, Vertes, Andras, Sebo, Judit, Davidovits, Zoltan, Matics, Laszlone, Varga, Albert, Ágoston, Gergely, Fontos, Geza, Dekany, Gabor, Merkely, Bela, Bartykowszki, Andrea, Maurovich-Horvat, Pal, Kerecsen, Gabor, Jakal, Agnes, Hinic, Sasa, Djokic, Jelena, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Djordjevic-Dikic, Ana D., Petrovic, Marija T., Giga, Vojislav L., Dobric, Milan R., Stepanovic, Jelena J., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic-Adjic, Nada, Velicki, Lazar, Kamenica, Sremska, Pupic, Ljiljana, Davidović, Goran, Simović, Stefan M., Vučić, Rada, Dekleva, Milica Nikola, Martinovic, Miroslav Stevo, Stevanovic, Gordana, Stankovic, Goran, Dobric, Milan, Apostolovic, Svetlana, Martinovic, Sonja Salinger, Stanojevic, Dragana, Escobedo, Jorge, Jesús-Pérez, Ramon de, Juarez, Benito, Baleón-Espinosa, Rubén, Campos-Santaolalla, Arturo S, Durán-Cortés, Elihú, Flores-Palacios, José M, García-Rincón, Andrés, Jiménez-Santos, Moisés, Peñafiel, Joaquín V, Ortega-Ramírez, José A, Valdespino-Estrada, Aquiles, Rosas, Erick Alexánderson, Canales Brassetti, María Fernanda, Vences Anaya, Diego Adrián, García, María Pérez, Carvajal Juarez, Isabel Estela, Rovalo, Magdalena Madero, Morales Rodríguez, Erick Donato, Selvanayagam, Joseph B., Rankin, Jamie, Murphy, Deirdre, Selvanayagam, Joseph B., Lee, Sau, Joseph, Majo X., Thomas, Prince, Thambar, Suku T., Chaplin, Melissa D, Boer, Stephanie C, Beltrame, John F., Stansborough, Jeanette K., Black, Marilyn, Hillis, Graham S., Bonner, Michelle M., Ireland, Kim F., Venn-Edmonds, Clare, Steg, Philippe-Gabriel, Abergel, Helene, Juliard, Jean-Michel, Thobois, Corine, Pasteur, C.H. Louis, Thuaire, Christophe, Tachot, Emilie, Dutoiu, Téodora, Laure, Christophe, Vassaliere, Christel, Steg, Philippe Gabriel, Abergel, Helene, Juliard, Jean-Michel, Fuentes, Axelle, Slama, Michel S., Eliahou, Ludivine, Cedex, Clamart, El Mahmoud, Rami, Dubourg, Olivier, Michaud, Pierre, Nicollet, Eric, Hadjih, Sarah, Cedex, Corbeil-Essonnes, Goube, Pascal, Brito, Patricia, Barone-Rochette, Gilles, Barone-Rochette, Gilles, Furber, Alain, Cornet, Charles, Bière, Loïc, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laucevicius, Aleksandras, Laukyte, Monika, Celutkiene, Jelena, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Kedhi, Elvin, Klinieken, Isala, Timmer, Jorik, Bouwhuis, Ilse, Hermanides, Rik, Nijmeijer, Lia, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, Jeannette, Schoep, J. M., Dongen, Elise van, Elisabeth, Janzen, M., Niehe, Sander R., Suryapranata, Harry, Ahoud, Sandra, Vugt, Stijn van, Ramos, Ruben, Santa Marta, Hospital de, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Selas, Mafalda, Bernanrdes, Luis, Silva, Filipa, Rio, Pedro, Freixo, Cláudia, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Cabrita, Inês Zimbarra, Menezes, Miguel Nobre, Rocha, Andreia, Lopes, Guilhermina Cantinho, Figueiras, Francisca Patuleia, Almeida, Ana Gomes, Coelho, Andreia, CanVas Silva, Pedro, Capinha, Marta, Nobre, Angelo, Caetano, Maria Inês, Francisco, Ana Rita, Silva, Susana, Ferreira, Nuno, de Gaia, Vila Nova, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, Tinnirello, Veronica, Figal, Julio César, Nicolás Mungo, Matías, Buenos Aires, Ciudad Autonoma de, Méndiz, Oscar, Cortés, Claudia, Favaloro, Roberto René, Alvarez, Carlos, Garcia, Marina, Blanca, Bahia, Courtis, Javier, Godoy, Valeria, Zeballos, Gabriela, Schiavi, Lilia, Actis, Maria Victoria, Rubio, Mariano, Scaro, Graciela, White, Harvey Douglas, Alsweiler, Caroline, Devlin, Gerard Patrick, Low, Liz, Fisher, Raewyn, Scales, Jayne, Abercrombie, Kirsty, Stewart, Ralph Alan Huston, Howell, Leah, White, Harvey Douglas, Patten, Cathrine, Benatar, Jocelyne, Kedev, Sasko, Mitevska, Irena Peovska, Kostovska, Elizabeta Srbinovska, Pejkov, Hristo, Held, Claes, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Björklund, Christina, Johnston, Nina, Andreasson, Maria, Olsowka, Maciej, Essermark, Marie, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Persson, Liselotte, Beyar, Rafael, Sharir, Tali, Nikolsky, Eugenia, Sharir, Tali, Harel, Or, Elian, Dan, Kerner, Arthur, Bentzvi, Margalit, Massalha, Samia, Helmer, Ludmila, Kohsaka, Shun, Fukuda, Keiichi, Ueda, Ikuko, Kohsaka, Shun, Fujita, Jun, Yasuda, Satoshi, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nishimura, Shigeyuki, Nakano, Shintaro, de Werf, Frans Van, Goetschalckx, Kaatje, Goetschalckx, Kaatje, Robesyn, Valerie, de Werf, Frans Van, Claes, Kathleen, White, Harvey Douglas, Alsweiler, Caroline, Hung, Chung-Lieh, Yang, Yi-Hsuan, Yun, Chun-Ho, Hou, Charles Jia-Yin, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Philander (Nee Talliard), Constance, Viljoen, Charle A, Mtana, Noloyiso, De Andrade, Marianne, Maggioni, Aldo P., Moccetti, Tiziano, Anesini, Adriana, Rossi, M.Grazia, Maspoli, Simona, Mombelli, Manuela, Abdelhamid, Magdy, Talaat, Ahmed, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, Kaffas, Sameh El, Fishawy, Hussien El, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Rosca, Monica, Deleanu, Dan, Beladan, Carmen C., Iliescu, Vlad A., Al-Mallah, Mouaz H., Zahrani, Sarah, Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Mogrovejo Ramos, Walter Enrique, Monsalve Davila, Marco Antonio, White, Harvey Douglas, Alsweiler, Caroline, Kuanprasert, Srun, Mai, Chiang, Prommintikul, Arintaya, Nawarawong, Weerachai, Khwakhong, Supatchara, Woragidpoonpol, Surin, Chaiyasri, Anong, Tepsuwan, Thitipong, Mekara, Warangkana, Taksaudom, Noppon, Kulthawong, Supap, Rimsukcharoenchai, Chataroon, Amaritakomol, Anong, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Panpunuan, Pachara, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, White, Harvey Douglas, Alsweiler, Caroline, Khairuddin, Ahmad, Mokhtar, Noor Syamira, Hadi, Hafidz Abd, Basri, Nor Asiah, Yahaya, Shaiful Azmi, Yusnida, Irni, Hashim, Humayrah, Harrington, Robert, Williams, David, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, Mark, Daniel, O’Brien, Sean M., Rosenberg, Yves, Shaw, Leslee J., Ballantyne, Christie, Berman, Daniel, Beyar, Rafael, Bhargava, Balram, Buller, Chris, (Tony) Carvalho*, Antonio, Chaitman, Bernard R., Diaz, Rafael, Doerr, Rolf, Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Hachamovitch, Rory, Hamm, Christian, Held, Claes, Helm, Malte, Huber, Kurt, Jiang, Lixin, Keltai, Matyas, Kohsaka, Shun, Lang, Irene, Lopes, Renato, Lopez-Sendon, Jose, Maggioni, Aldo, Bairey Merz, C. Noel, Min, James, Peterson, Eric, Picard, Michael H., Selvanayagam, Joseph, Senior, Roxy, Sharir, Tali, Steg, Gabriel, Szwed, Hanna, de Werf, Frans Van, Weintraub, William, White, Harvey, Williams, David, Ballantyne, Christie, Calfas*, Karen, Chaitman, Bernard R., Champagne, Mary Ann, Davidson, Michael, Fleg, Jerome, McCullough, Peter A., Stone, Peter, Menasche, Philippe, Davidson*, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Williams, David, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, Bruyne, Bernard de, Généreux, Philippe, Harrington, Robert, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Mahaffey, Ken, White, Harvey, Chaitman, Bernard R., Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Alexander, Karen P., Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Shaw, Leslee J., Berman, Daniel, Friedrich, Matthias, Hachamovitch, Rory, Kwong, Raymond, Min, James, Oliver, Dana, Picard, Michael H., Harrell, Frank, Blume, Jeffrey, Lee, Kerry, O’Brien, Sean M., Berger, Jeffrey, Held, Claes, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Mark, Daniel, Cohen, David, Weintraub, William, Merz, C. Noel Bairey, Bugiardini, Raffaele, Celutkiene, Jelena, Escobedo, Jorge, Hoye, Angela, Lyubarova, Radmila, Mattina, Deirdre, Peteiro, Jesus, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, O’Brien, Sean M., Rosenberg, Yves, Mark, Daniel, Mark, Daniel, Shaw, Leslee J., Berman, Dan, Chaitman, Bernard R., Fleg, Jerome, Kwong, Raymond, Picard, Michael H., Senior, Roxy, Min, James, Leipsic, Jonathan, Ali, Ziad, Williams, David, Fleg, Jerome, Berger, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Alexander, Karen P., Fleg, Jerome, Mathew, Roy, O’Brien, Sean M., Sidhu, Mandeep, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Gibson, C. Michael, Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Harrell, Frank, Nwosu, Samuel, Rosenberg, Yves, Fleg, Jerome, Kirby, Ruth, Jeffries, Neal, Berger, Jeffrey, Sidhu, Mandeep, Denaro*, Jean E., Mavromichalis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Loo, Kerrie Van, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne, Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, O’Brien, Sean M., Alexander, Karen P., Mark, Daniel B., Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, Knight, J David, Liu, Diane Minshall, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Wang, Grace Jingyan, Shaw, Leslee J., Phillips, Lawrence, Goyal, Abhinav, Hetrick, Holly, Oliver, Dana, Berman, Daniel, Hayes, Sean W., Friedman, John D., Gerlach, R. James, Hyun, Mark, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Kwong, Raymond Y., Friedrich, Matthias, Mongeon, Francois Pierre, Michael, Steven, Picard, Michael H., Hung, Judy, Scherrer-Crosbie, Marielle, Zeng, Xin, Chaitman, Bernard R., Eckstein, Jane, Guruge, Bandula, Streif, Mary, Ali, Ziad, Genereux, Philippe, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Min, James, Arsanjani, Reza, Budoff, Matthew, Elmore, Kimberly, Gomez, Millie, Hague, Cameron, Hindoyan, Niree, Leipsic, Jonathan, Nakanishi, Rine, Srichai-Parsia, M. Barbara, Yeoh, Eunice, Youn, Tricia, Maggioni, Aldo P., Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Tricoli, Martinia, Carvalho, Antonio, Lopes, Renato, Barbosa, Lilian Mazza, Duarte, Tauane Bello, Soares, Tamara Colaiácovo, Aveiro Morata, Julia de, Carvalho, Pedro, Carvalho Maffei, Natalia de, Egydio, Flávia, Kawakami, Anelise, Oliveira, Janaina, Piloto, Elissa Restelli, Pozzibon, Jaqueline, Goodman, Shaun, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Jiang, Lixin, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Diaz, Rafael, Escobar, Claudia, Martin, Maria Eugenia, Pascual, Andrea, Lopez-Sendon, José, Moraga, Paloma, Hernandez, Victoria, Castro, Almudena, Posada, Maria, Fernandez, Sara, Villanueva, José Luis Narro, Selgas, Rafael, Steg, Gabriel, Abergel, Helene, Juliard, Jean Michel, White, Harvey, Alsweiler, Caroline, de Werf, Frans Van, Claes, Kathleen, Goetschalckx, Kaatje, Luyten, Ann, Robesyn, Valerie, Selvanayagam, Joseph B., Murphy, Deirdre, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata

Published
2024
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22. Hexavalent chromium removal by green synthesized nano-size iron particles combined with iron sulfides: Effects of dissolved oxygen and phosphate

Author

Gao, Weidong, Chen, Haijun, Ma, Xinyue, Xu, Nan, Feng, Fang, and Zhang, Shan

Abstract

The removal of hexavalent chromium (Cr(VI)) from wastewater using the green synthesized nano-zero-valent-iron (GnZVI) has attracted great attention. However, the Cr(VI) removal capacity of GnZVI remains limited by dissolved oxygen (DO) or phosphate in wastewater. Therefore, Cr(VI) removal by GnZVI combined with iron sulfides (i.e., FeS or FeS2) impacting by DO and phosphate was investigated at pH 2.0 and 6.0. Experimental results showed that DO inhibited the Cr(VI) removal by GnZVI with FeS at pH 2.0, because high DO saturation was beneficial to Fe(II) oxidization into Fe(III). Nevertheless, DO promoted the corrosion and dissolution of FeS2but GnZVI for Cr(VI) reduction at pH 2.0. Especially, phosphate inhibited the Cr(VI) reduction by the combination of GnZVI and iron sulfides at pH 2.0, likely because phosphate inhibited Fe(II) release from GnZVI hybrid materials during the reduction process from Cr(VI) to Cr (III). Differently, at pH 6.0, phosphate mainly promoted Cr(VI) removal by FeS compared with GnZVI via the formation of phosphate complexation, while it inhibited Cr(VI) removal using GnZVI combined with FeS2through the competitive adsorption. This study reveals the potential inherent mechanisms and emphasizes a sustainable strategy for the effective removal of Cr(VI) using a hybrid technique that combines GnZVI and iron sulfides under complex wastewater conditions.

Published
2024
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25. Switching of Enantioselectivity in the Cu-Catalyzed Asymmetric Decarboxylative Aldol Reaction of Tryptanthrin with β-Keto Acids: An Unexpected Counteranion Effect

Author

Feng, Fang-Fang, Wang, Xue-Qi, Sun, Long, Cheung, Chi Wai, Nie, Jing, and Ma, Jun-An

Abstract

Cu-bisoxazoline-catalyzed enantioselective decarboxylative aldol reaction of tryptanthrin with aryl-substituted β-keto acids is developed, providing a straightforward approach to deliver a series of phaitanthrin A analogues. Both enantiomers of the products can be obtained with good to high enantioselectivity in the presence of a single chiral ligand by simply changing the copper salts. Based on the X-ray crystallographic analysis of chiral Cu(II)-bisoxazoline complexes, the tentative stereochemical models are presented to account for the observed counteranion-induced switching in enantioselectivity.

Published
2021
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26. Cu-Enabled [3 + 2] Annulation of In SituFormed Nitrile Ylides with Aryldiazonium Salts: Access to 5-Cyano-1,2,4-Triazoles

Author

Zhou, Lu-Nan, Feng, Fang-Fang, Cheung, Chi Wai, and Ma, Jun-An

Abstract

The unified construction of cyano-substituted 1,2,4-triazoles, particularly the 5-cyano counterparts, remains underdeveloped. Herein we describe a three-component method to access a wide range of 1-aryl 5-cyano-1,2,4-triazoles using readily available 2-diazoacetonitriles, nitriles, and aryldiazonium salts. This regiospecific synthesis relies on the dipolar [3 + 2] annulation of the in situformed nitrile ylides with aryldiazonium salts. Furthermore, this protocol can be amendable to gram-scale synthesis, chemical transformations of the nitrile moieties, and access to chiral bis(cyano-triazole)-1,1′-naphthalene, which would all be likely applicable in the synthesis of structurally diverse bioactive compounds and novel bidentate ligands for asymmetric catalysis.

Published
2021
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27. General Synthesis of Tri-Carbo-Substituted N2-Aryl-1,2,3-triazoles viaCu-Catalyzed Annulation of Azirines with Aryldiazonium Salts

Author

Feng, Fang-Fang, Li, Jun-Kuan, Liu, Xuan-Yu, Zhang, Fa-Guang, Cheung, Chi Wai, and Ma, Jun-An

Abstract

The general synthesis of fully substituted N2-aryl-1,2,3-triazoles is hitherto challenging compared with that of the N1-aryl counterparts. Herein, we describe a Cu-catalyzed annulation reaction of azirines and aryldiazonium salts. This regiospecific method allows access to a broad spectrum of tri-carbo N2-aryl-1,2,3-triazoles substituted with diverse aryl and alkyl moieties. Its utility is highlighted by the synthesis of several triazole precursors applicable in drug discovery, as well as novel chiral binaphthyl ligands bearing triazole moieties.

Published
2020
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28. Experimental and Numerical Study of the Ultrasonic Atomization Pyrolysis Process toward Mass Production of Photocatalysts

Author

Wang, Jian, Feng, Fang, Wang, Chang, Yan, Wei-Cheng, and Shi, Weidong

Abstract

Ultrasonic atomization pyrolysis (UAP) is an effective method for the mass production of micro-/nano-photocatalysts; however, studies on particle-flow behaviors and the collection efficiency were seldom reported, which are very important for its scale-up and industrialization. In this study, a computational fluid dynamics model was developed to simulate the UAP process. Experiments were carried out via a self-designed UAP setup to validate the developed model. A two-way coupling discrete phase model considering particle collision and breakage was employed to investigate the influence of operating conditions (for example, carrying gas flow rate, precursor concentration, ultrasonic frequency, particle injection rate, and temperature) on the collection efficiency and particle-flow behaviors. Effects of particle polydispersity were also studied based on the developed model. Finally, three types of UAP reactors were designed based on the developed model, and the results suggested that a T-shape reactor possessed higher particle collection efficiency. This study could help to understand the particle-flow behaviors inside the reactor, and the developed model could serve as a tool to optimize the design and operation of the UAP reactor toward large-scale production of photocatalysts.

Published
2020
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30. Anomaly detection in ad-hoc networks based on deep learning model: A plug and play device.

Author

Feng, Fang, Liu, Xin, Yong, Binbin, Zhou, Rui, and Zhou, Qingguo

Subjects
AD hoc computer networks, ANOMALY detection (Computer security), DEEP learning, WIRELESS communications, ARTIFICIAL neural networks
Abstract

Abstract Ad-hoc network is a temporary self-organizing network that needs no fixed infrastructure. So it has been applied extensively in many areas requesting temporary communication such as military field, emergency disaster relief and road traffic. While, due to the feature of self-organization and wireless communication channels, ad-hoc network is more vulnerable to various attacks compared to the traditional network. In this paper, we proposed a plug and play device to detect Denial of Service (DoS) and privacy attacks. This device mainly includes capture tool and deep learning detection model. Capture tool is used to grab packets in ad-hoc networks, deep learning detection model is used for detecting attacks. An alarm will be triggered if the detected result is attack. In this way, we can avoid the detected attack to spreading out in larger scale. The proposed method can be used as the second line of dense to issue the early-warning signal. In the experiment, first, we use Deep neural network (DNN) detection model to detect DoS attacks; next, we use DNN, Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) detection model to detect XSS and SQL attacks. The results show that these detection models can achieve very high Accuracy, Precision, Recall and F 1 − s c o r e. In addition, the time efficiency among the CNN, the LSTM and the DNN is in acceptable range. It proofs that the proposed method can be effectively applied for attack detection. It is important to note that the proposed method can be extended to all other attacks with little modification in ad-hoc networks. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation

Author

Hu, Shiliang, Tong, Linjiang, Qin, Qiao, Wen, Jiaxin, Li, Yan, Feng, Fang, Wu, Kunzhong, Zhou, Yang, Shang, Jinsai, Wang, Junjian, Liu, Jinbao, Xie, Hua, and Lu, Xiaoyun

Abstract

Overcoming clinical resistance to osimertinib mediated by the tertiary C797S mutation remains an unmet medical need. To date, there are no effective drugs that have been approved for patients who harbor EGFRT790M/C797Smutations. Herein, we applied a structure-based drug design strategy to discover a series of potent and selective diaminopyrimidine macrocycles as novel EGFRT790M/C797Sinhibitors. The representative compound 21vpotently inhibited EGFR19del/T790M/C797Sand EGFRL858R/T790M/C797Smutants with IC50values of 2.3 nM and 12.5 nM, respectively, and exhibited antiproliferative activity against Ba/F3-EGFR19del/T790M/C797Sand Ba/F3-EGFRL858R/T790M/C797Scells with IC50values of 41 and 52 nM, respectively. Further, 21vinhibited proliferation of the EGFR19del/T790M/C797Smutant PC-9-OR NSCLC cell line with an IC50value of 56 nM and displayed selectivity over parental Ba/F3 and A431 cells. Moreover, 21vexhibited antitumor efficacy in a Ba/F3-EGFR19del/T790M/C797Sxenograft model. This study provides a promising macrocyclic lead for anticancer drug discovery overcoming EGFRC797Smutation mediated resistance in NSCLC patients.

Published
2024
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32. Effects of drought and rewatering on leaf photosynthesis, chlorophyll fluorescence, and root architecture of citrus seedlings.

Author

WEI Qing-jiang, FENG Fang-fang, MA Zhang-zheng, SU Shou-ting, NING Shao-jun, and GU Qing-qing

Abstract

Drought, severely affects citrus growth and development. In order to explore the mechanism of drought, response of citrus, two cultivars ( Sanhuhongju and Sanhuhuahong) that differing in drought tolerance were used as materials. The drought and rewatering treatment was conducted in pot experiments, with leaf photosynthesis, chlorophyll fluorescence, and root architecture being measured. The results showed that drought significantly decreased net photosynthetic rate (Pn), stomatal conductance {g), transportation rate (Tr), and intercellular CO2 concentration ( Ci ) of both cultivars, but Sanhuhongju generally showed less reduction. After rewatering, photosynthetic parameters were partly recovered but still lower than that in control. The water use efficiency (WUE) of Sanhuhongju was significantly increased after drought stress for 15 d, but the WUE of Sanhuhuahong was decreased except at the 15 day of drought stress. In addition, the maximum photosynthesis efficiency of PS II ( Fv/Fm ) was increased in both cultivars, but the photochemical quantum yield of PS II [ Y (II) ] was increased in Sanhuhuahong under drought. Both the apparent electron transport rate (ETR) and photochemical quenching (qP) were inhibited in the treated seedlings. The non-photochemical quenching (MPQ) was decreased in Sanhuhongju while increased in Sanhuhuahong under drought and rewatering conditions. Drought stress resuked in the decrease of root surface area and volume of both cultivars, and it inhibited root elongation of Sanhuhuahong while improved the root length and root tip number of Sanhuhongju. The length of first lateral roots of Sanhuhongju was increased after drought stress 10 d, but did not change at the drought. stress prophase of Sanhuhuahong, and then significantly decreased after 20 d. Furthermore, drought. stress inhibited all lateral roots development except the tertiary lateral root of Sanhuhongju, and root growth could not be recovered by rewatering except root tip number. In conclusion, Sanhuhongju showed less reduction in leaf photosynthesis than Sanhuhuahong, wkh higher WUE and light use efficiency under drought stress. The increases of root tip number and lateral root length would help improve water uptake ability in Sanhuhongju. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Chapter Seven - Screening, Efficacy and Mechanisms of Microbial Control Agents Against Sucking Pest Insects as Thrips.

Author

Shengyong Wu, Liangde Tang, Feng Fang, Donggang Li, Xin Yuan, Zhongren Lei, and Yulin Gao

Abstract

Polyphagous thrips are among the most important economically pests that cause serious damage in various ornamental and vegetable crops throughout the world. Because of their small size and cryptic habits, a number of thrips species are easy to invade into new areas. For a long period, thrips control has mainly relied on frequent use of insecticides, which lead to a series of ecological problems. Although a number of alternative management tactics have been developed in many cropping systems, many invasive thrips continue to spread internationally and display vast damage potential. This chapter reviews microbial control of thrips with focus on the entomopathogenic fungi Beauveria bassiana, Metarhizium anisopliae, Isaria fumosorosea and Lecanicillium lecanii. The strains of fungal pathogens that were screened and proven to be effective for control of thrips should be developed worldwide and available for growers. We also discuss three areas of future research that will be necessary in improving management programs of thrips. [ABSTRACT FROM AUTHOR]

Published
2018
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36. Chiral β-Keto Propargylamine Synthesis via Enantioselective Mannich Reaction of Enamides with C-Alkynyl N-Boc N,O-Acetals

Author

Feng, Fang-Fang, Li, Shen, Cheung, Chi Wai, and Ma, Jun-An

Abstract

Propargylamines are an important class of compounds in organic synthesis and drug discovery, yet the synthesis of chiral β-keto propargylamines remains underdeveloped. Herein, we describe a streamlined and general enantioselective Mannich reaction of enamides with C-alkynyl N-Boc N,O-acetals, which serve as readily available C-alkynyl imine precursors, to access a broad range of chiral β-keto N-Boc-propargylamines bearing single stereogenic centers in high yields (up to 98%) and in high enantioselectivities (up to 95% ee).

Published
2019
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37. Effects of Offset Blade on Aerodynamic Characteristics of Small-Scale Vertical Axis Wind Turbine

Author

Li, Yan, Zhao, Shouyang, Qu, Chunming, Feng, Fang, and Kotaro, Tagawa

Abstract

A new way of connecting blade to rotor shaft named offset blade method was proposed for straight-bladed vertical axis wind turbine (SB-VAWT) in this study. In order to invest the efficiency of this method and effects of main parameters including offset length and blade airfoil on improving the output power performance and static starting characteristics, numerical simulations and wind tunnel tests were carried out. Four kinds of blade airfoil including NACA0012, NACA0018, NACA0024 and S809 were selected to analyze the influence of blade thickness and symmetry on SB-VAWT with offset blade. Numerical simulations were firstly carried out on output power for the rotor with 6 kinds of offset length for each airfoil. Wind tunnel tests were also carried out to compare with the results of simulations. The flow fields of rotor with different offset lengths were simulated and the effects of offset blade were analyzed. The optimum offset length among all studied for output power performance was found. Furthermore, the static starting torque and aerodynamic force characteristics of the rotor with optimum offset length were researched. According to the results, appropriate offset length can improve the output power characteristics and smooth the fluctuations of the static torque during one rotational period. The best offset length varies with the airfoil.

Published
2019
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38. Bone morphogenetic protein-2 loaded poly(D,L-lactide-co-glycolide) microspheres enhance osteogenic potential of gelatin/hydroxyapatite/β-tricalcium phosphate cryogel composite for alveolar ridge augmentation.

Author

Chang, Hao-Chieh, Yang, Connie, Feng, Fang, Lin, Feng-Huei, Wang, Chi-Hwa, and Chang, Po-Chun

Subjects
MANDIBLE surgery, ANIMAL experimentation, ANIMALS, BONE morphogenetic proteins, BONE regeneration, COMPUTED tomography, CULTURE media (Biology), OPERATIVE dentistry, PHARMACEUTICAL gels, DENTAL implants, LACTIC acid, LATEX, MINERALS, POLYESTERS, PROTEINS, RATS, TISSUE engineering, EQUIPMENT & supplies
Abstract

Background/purpose: Sufficient bony support is essential to ensure the success of dental implant osseointegration. However, the reconstruction of vertical ridge deficiencies is still a major challenge for dental implants. This study introduced a novel treatment strategy by infusing poly(D,L-lactide-co-glycolide) (PLGA) microspheres encapsulating bone morphogenetic protein-2 (BMP-2) within a gelatin/hydroxyapatite/β-tricalcium phosphate (gelatin/HA/β-TCP) cryogel composite to facilitate supra-alveolar ridge augmentation.Methods: The gelatin scaffold was crosslinked using cryogel technique, and HA/β-TCP particles were mechanically entrapped to form the gelatin/HA/β-TCP composite. Co-axial electrohydrodynamic atomization technology was used to fabricate PLGA microspheres encapsulating BMP-2. The composites of gelatin/HA/β-TCP alone, with infusion of BMP-2 solution (BMPi) or microspheres (BMPm), were fixed on rat mandibles using a titanium mini-implant for 4 weeks, and the therapeutic efficiency was evaluated by micro-computed tomography, bone fluorochrome, and histology.Results: The gelatin/HA/β-TCP composite was homogenously porous, and BMP-2 was sustained release from the microspheres without initial burst release. Ridge augmentation was noted in all specimens treated with the gelatin/HA/β-TCP composite, and greater bone deposition ratio were noted in Groups BMPi and BMPm. Compared with Group BMPi, specimens in Group BMPm showed significantly greater early osteogenesis and evident osseointegration in the supra-alveolar level.Conclusion: BMP-2 loaded PLGA microspheres effectively promoted osteogenic potential of the gelatin/HA/β-TCP composite and facilitated supra-alveolar ridge augmentation in vivo. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

Author

Liu, Ying-Qiang, Wang, Ya-Nan, Lu, Xiao-Yun, Tong, Lin-Jiang, Li, Yan, Zhang, Tao, Xun, Qiu-Ju, Feng, Fang, Chen, Yu-Zhe, Su, Yi, Shen, Yan-Yan, Chen, Yi, Geng, Mei-Yu, Ding, Ke, Li, Yan-Li, Xie, Hua, and Ding, Jian

Abstract

Colony-stimulating factor 1 receptor (CSF1R) plays a critical role in promoting tumor progression in various types of tumors. Here, we identified D2923 as a novel and selective inhibitor of CSF1R and explored its antitumor activity both in vitro and in vivo. D2923 potently inhibited CSF1R in vitro kinase activity with an IC50value of 0.3 nM. It exhibited 10- to 300-fold less potency against a panel of kinases tested. D2923 markedly blocked CSF-1-induced activation of CSF1R and its downstream signaling transduction in THP-1 and RAW264.7 macrophages and thus inhibited the in vitro growth of macrophages. Moreover, D2923 dose-dependently attenuated the proliferation of a small panel of myeloid leukemia cells, mainly by arresting the cells at G1 phase as well as inducing apoptosis in the cells. The results of the in vivo experiments further demonstrated that D2923 displayed potent antitumor activity against M-NFS-60 xenografts, with tumor growth inhibition rates of 50% and 88% at doses of 40 and 80 mg/kg, respectively. Additionally, D2923 was well tolerated with no significant body-weight loss observed in the treatment groups compared with the control. Furthermore, a western blot analysis and the immunohistochemistry results confirmed that the phosphorylation of CSF1R in tumor tissue was dramatically reduced after D2923 treatment, and this was accompanied by the depletion of macrophages in the tumor. Meanwhile, the expression of the proliferation marker Ki67 was also markedly decreased in the D2923 treatment group compared with the control group. Taken together, we identified D2923 as a novel and effective CSF1R inhibitor, which deserves further investigation.

Published
2018
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42. Plasma metabolic profiling analysis of normal and ANIT-induced cholestasis rats after oral administration of Da-Huang-Xiao-Shi decoction using UHPLC-Q-Orbitrap MS coupled with pattern recognitionElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ay01945b

Author

Zhu, Guoxue, Chen, Yiling, Hu, Qing, Zhang, Qianying, Lv, Qi, and Feng, Fang

Abstract

Da-Huang-Xiao-Shi decoction (DHXSD) is a representative formula for treating jaundice and could have bright prospects owing to its liver protecting effects. DHXSD might synthetically result in a change in the metabolic profiles of cholestasis rats compared with that of normal rats after oral administration. Metabolic profiling analysis has gained significant attention ever since the field of metabolomics began to develop. In this study, a highly sensitive, rapid and high chromatographic resolution ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) combined with multivariate statistical analysis method was established to investigate the metabolic profiles of DHXSD in normal and alpha-naphthylisothiocyanate (ANIT)-induced cholestasis rats. In addition, serum biochemical indices and pathological observation analysis were utilized to evaluate the animal model. As a result, a total of 68 prototype compounds and metabolites in normal and cholestasis rats in vivowere screened and tentatively identified according to their exact mass and the relevant literature. Among these, 15 of the compounds were filtered out as potential chemical markers that may be responsible for the pharmacological effects of DHXSD, which offers a basic foundation for quality evaluation, pharmacokinetic research and the clinical safety of drug usage. In conclusion, this study provides an insight into the metabolism of DHXSD in vivoto enable understanding of the metabolic process and therapeutic mechanism of cholestasis.

Published
2018
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43. Organocatalyst‐Controlled Divergent Asymmetric Aza‐Friedel‐Crafts Reactions of Indol‐3‐ones with 1‐ and 2‐Naphthols

Author

Zheng, Jie, Rong, Meng‐Yu, Feng, Fang‐Fang, Zhang, Fa‐Guang, Cheung, Chi Wai, and Ma, Jun‐An

Abstract

Indol‐3‐ones are readily available reaction substrates, but their utility in asymmetric reactions is underdeveloped. Herein, we describe the organocatalytic asymmetric aza‐Friedel‐Crafts‐type reaction of indol‐3‐ones with 1‐ and 2‐naphthols. By using spirocyclic chiral phosphoric acids and quinine‐incorporated squaramides as the organocatalysts, two classes of structurally distinct chiral compounds, namely 2‐(hydroxylnaphthyl)‐indolin‐3‐ones and tetrahydrofuroindoles, are formed respectively. These quaternary centre‐containing indoline derivatives may find use in the synthesis of biologically active molecules. The asymmetricaza‐Friedel‐Crafts‐type reactions of indol‐3‐ones with 1‐ and 2‐naphthols are developed to access structurally distinct chiral 2‐(hydroxynaphthyl)‐indolin‐3‐ones and tetrahydrofuroindoles, respectively.

Published
2023
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44. Stable isotopes in precipitation and atmospheric moisture of Pailugou Catchment in northwestern China′s Qilian Mountains

Author

Feng, Fang, Feng, Qi, Liu, Xiande, Wu, Jinkui, and Liu, Wei

Abstract

Hydrogen and oxygen isotopes in precipitation have been widely used as effective traces to investigate hydrological processes such as evaporation and atmospheric moisture source. This study analyzed δD and δ18O of precipitation in continuous event-based samples at three stations of Pailugou Catchment from November 2012 to December 2013. The δ18O and δD values ranged from −32.32‰ to +3.23‰ and from −254.46‰ to +12.11‰, respectively. Results show that the δ18O displayed a distinct seasonal variation, with enriched values occurring in summer and relatively depleted values in winter, respectively. There was a statistically significant positive correlation between the δ18O and δD values and local surface air temperature at all the three stations. The nearest Global Network of Isotopes in Precipitation (GNIP) station (Zhangye), compared to the Meteoric Water Lines for this study, showed the obvious local evaporation effects with lower intercept and slope. Additionally, d-excess (δD − 8δ18O) parameter in precipitation exhibited an anti-phase seasonal variability with the δ18O. The 96-h back trajectories for each precipitation event using Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model indicated a dominant effect of westerly air masses in summer and the integrated influence of westerly and polar air masses in winter.

Published
2017
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45. A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosisElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ay02863b

Author

Wu, Huan, Wang, Dan, Meng, Jin, Wang, Juanjuan, and Feng, Fang

Abstract

Zhi-Zi-Da-Huang decoction (ZZDHD) is a classical traditional Chinese medicine (TCM) prescription that has been widely used to treat alcoholic liver disease over a millennium in China. However, the hepatoprotective mechanism of ZZDHD remains obscure. In this work, an untargeted metabolomic study based LC-TOF/MS and LC-QqQ/MS was conducted to explore plasma metabolic changes of ZZDHD intervention to alcohol-induced hepatic steatosis (AHS). The XCMS Online platform was used for nonlinear alignment of the data in the time domain, metabolite feature annotation and extraction of the peak intensities. Principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA) were used to examine the data in a multivariate setting. The observations in control, AHS and ZZDHD-dosed groups could be clearly distinguished by PCA and the ZZDHD-dosed group displayed a distinct returning trend to the control group. 16 potential biomarkers which contribute to the therapeutic mechanism of ZZDHD on AHS rats were screened by OPLS-DA. These potential biomarkers mainly involved in the metabolism of amino acids, phospholipids, fatty acids, cholesterols and sphingolipid, which could be useful to further investigate the characteristics of AHS and the hepatoprotective effects of ZZDHD. This study also illustrates that the untargeted metabolomic method is a promising method to identify candidate metabolic biomarkers and understand the mechanism of TCM.

Published
2017
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46. Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.

Author

Hu, XueQing, Qi, Cong, Feng, Fang, Wang, Yan, Di, TingTing, Meng, YuJiao, Wang, Yazhuo, Zhao, Ning, Zhang, XiaWei, Li, Ping, and Zhao, Jingxia

Abstract

Background: Psoriasis is a prevalent chronic inflammatory skin condition marked by immune cell infiltration and keratinocyte abnormal proliferation. Cimicifugae Rhizoma - Smilax glabra Roxb (CS) herb pair, the main component of Shengma Detoxification Decoction, has been proven effective for the treatment of psoriasis. However, the mechanism is yet to be deciphered.Purpose: To explore the mechanism of CS for the treatment of psoriasis.Methods: The imiquimod-induced psoriasis-like lesion mouse model was used to identify the targets and the molecular mechanisms of CS. Network pharmacology combined with RNA-seq strategy was employed to predict the targets and mechanisms of CS for psoriasis. Metabolomics approaches were used to demonstrate the complexity of CS for the treatment of psoriasis. Finally, a compound-response-enzyme-gene network was constructed based on the multi-omics results to elucidate potential connections.Results: The CS herb pair could significantly improve psoriatic lesions and reduce the inflammatory cell infiltration and proliferation of keratinocytes in skin lesions. Network pharmacology predicted that TNF, JNK, IL-6, and IL-1β could be potential targets. RNA-seq data revealed that CS could significantly regulate genes and signaling pathways associated with Th17 responses, such as IL-36, IL-1β, CCl2, CXCL16, keratin 14, keratin 5, and antimicrobial peptides S100A8 and S100A9 well as MAPK, mTOR, and other signaling pathways. Further experimental data validated that CS treatment remarkably reduced the expression of inflammatory cytokines and factors, such as CCL2, CCL7, IL1F6, IL-17, IL-23, IL-1β, TNF-α, and IL-6, and inhibited the phosphorylation of p38 and ERK1/2. This indicated that CS exerts its therapeutic effect by inhibiting the MAPK signaling pathways. In addition, metabolomic analyses demonstrated that CS treatment improved seven metabolic pathways, these included phenylalanine, tyrosine, pyruvate metabolism, carnitine metabolism, etc. Four key metabolites (L-Arginine, L-Phenylalanine, L-Carnitine, O-Acetylcarnitine) and nine differential genes (CMA1, PCBD2, TPSAB1, TPSB2, etc.) were identified that affected amino acid metabolism, carnitine metabolism, and other pathways contributing to the infiltration of Th17 cells in psoriatic lesions.Conclusion: CS could alleviate IMQ-induced psoriasis-like dermatitis by reducing the expression of cytokines and chemokines mediated by the MAPK pathway, and improved amino acid and carnitine metabolism in vivo. Our study is the first to demonstrate the complex mechanism of CS for the treatment of psoriasis and provides a new paradigm to elucidate the pharmacological effects of Traditional Chinese Medicine (TCM) drugs for psoriasis from multiple perspectives. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Association between apolipoprotein E gene polymorphism and depression.

Author

Feng, Fang, Lu, Shan-Shan, Hu, Cai-Yun, Gong, Feng-Feng, Qian, Zhen-Zhong, Yang, Hui-Yun, Wu, Yi-Le, Zhao, Yuan-Yuan, Bi, Peng, and Sun, Ye-Huan

Abstract

We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59–0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58–0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07–1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06–1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Application of a flexible visitation system in critically ill patients: A randomized clinical trial

Author

Yang, Hu-yong, Feng, Fang, Yang, Wei-wei, and Chen, Yu

Abstract

Objective: To determine the feasibility of a flexible visitation system in the intensive care unit (ICU).Methods: A randomized, open-label, parallel group clinical trial was conducted. All patients admitted to the ICU of the Lanzhou University Second Hospital from April to June 2022 were enrolled. The enrolled patients were randomly divided into an experimental group and a control group according to a computer-generated random sequence table.Results: A total of 410 patients were admitted. According to the inclusion and exclusion criteria, 140 patients were included in the experimental group (flexible visitation group) and 140 in the control group (normal visitation group). The average number of visitation minutes per day between the experimental group and the control group was 24.7 versus 23.9 min (p> 0.05).Among the outcome indicators, delirium occurred in 8 (5.7%) patients in the intervention group and in 24 (17.1%) patients in the control group (p= 0.003). Five complaints (mainly pressure ulcers) were received, with one in the experimental group and the others in the control group. There were 28 cases of nosocomial infection in the experimental group and 29 cases in the control group; therefore, the incidence of nosocomial infection was 20% versus 20.7% (p= 0.882). A total of 280 questionnaires were collected, with a retrieval rate of 100%. The satisfaction of patients in the experimental group and the control group was 98.6% and 92.1%, respectively (p= 0.011). The flexible visiting system reduced the ICU length of stay (LOS). The ICU LOS of the experimental group was 6 versus 8 days for the control group (p= 0.041). However, the flexible visiting system did not reduce the hospital stay (17 vs. 19 days, p= 0.923).Conclusion: Conducting a flexible visitation system in ICUs could reduce the incidence of delirium in critically ill patients and improve the quality of nursing care; furthermore, the rate of nosocomial infections was not increased. These findings need to be further verified by a multicentre, large-scale clinical trial.

Published
2023
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50. LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo‐Inspired pH/Tactility Artificial Receptors

Author

Yuan, Renqiang, Yang, Ning, Li, Weikun, Liu, Zonghao, Feng, Fang, Zhang, Qianli, and Ge, Liqin

Abstract

Besides barrier functions, skin possesses multiple sentiences to external stimuli (e.g., temperature, force, and humidity) for human‐outside interaction. Thus, skincare should be taken very seriously, especially by patients with sensory disorders. However, currently available skin‐mimicking devices are always limited by so much insufficient response functions and nontunable interface behaviors so as not to realize precise health monitoring and self‐defense against injury. Herein, a bioinspired cutaneous receptor‐perceptual system (CRPS) patch is presented, integrating hybrid pH indicators and triboelectric nanogenerators into biointerface film‐adhesives that are fabricated through facile layer‐by‐layer (LBL) self‐assembly of amide and Schiff‐base linkages between alginate grafted with N‐hydroxysuccinimide ester (AN), tannic acid (TA), and polyethylenimine (PEI). This CRPS patch is adhered robustly to the soft‐curved skin surface without failure via “molecular suturing,” and amino acid enables its benign peel‐on‐demand from tissue interfaces. Postdamage self‐healing brings it without surgical reoperation, avoiding extra cost, pain, as well as infection risks. Significantly, CRPS patches as artificial chemo/mechanoreceptors can remotely visualize skin physiological status by pH‐induced chromism using smartphones and prevent skin contact injury by tactility‐driven self‐powered electrical signals. Overall, the LBL‐based strategy to create controllably biointerface‐adhesive CRPS patches will usher in a new era of the mobihealth care platform supporting smart diagnosis and self‐protection. Advanced human skin‐mimicking devices remain challenging because of inherent complex physiological structures and functions. A pH/tactility dual‐sensing layer‐by‐layer self‐assembly film patch can monitor real‐time pH and contact injury well, sending immediate feedback of red, green, and blue (RGB) values and self‐powered current signals to an app. This patch with post‐adhesion removal‐on‐demand and post‐damage self‐healing properties features skin‐inspired receptors for digital healthcare.

Published
2023
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