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Association between apolipoprotein E gene polymorphism and depression.

Association between apolipoprotein E gene polymorphism and depression.

Authors :
Feng, Fang
Lu, Shan-Shan
Hu, Cai-Yun
Gong, Feng-Feng
Qian, Zhen-Zhong
Yang, Hui-Yun
Wu, Yi-Le
Zhao, Yuan-Yuan
Bi, Peng
Sun, Ye-Huan
Source :
Journal of Clinical Neuroscience; Aug2015, Vol. 22 Issue 8, p1232-1238, 7p
Publication Year :
2015

Abstract

We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59–0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58–0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07–1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06–1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09675868
Volume :
22
Issue :
8
Database :
Supplemental Index
Journal :
Journal of Clinical Neuroscience
Publication Type :
Academic Journal
Accession number :
103654825
Full Text :
https://doi.org/10.1016/j.jocn.2015.02.012