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Despite the high prevalence of ischemic heart diseases worldwide, no antibody-based treatment currently exists. Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) is particularly elevated in both patients and animal models of myocardial infarction, here we assess whether its inhibition by a specific monoclonal antibody reduces cardiac fibrosis. We find that this treatment reduces collagen deposition and cross-linking, paralleled by enhanced cardiomyocyte survival, both in vivo and in primary cultures of cardiac cells. Mechanistically, we show that the anti-BMP1.3 monoclonal antibody inhibits Transforming Growth Factor β pathway, thus reducing myofibroblast activation and inducing cardioprotection through BMP5. Collectively, these data support the therapeutic use of anti-BMP1.3 antibodies to prevent cardiomyocyte apoptosis, reduce collagen deposition and preserve cardiac function after ischemia., Here the authors show that a monoclonal antibody against a soluble isoform of Bone Morphogenetic Protein 1 prevents cardiac cell death, reducing fibrosis and preserving cardiac function after myocardial ischemia.

Despite continuous improvement in devices and a better understanding of the mechanisms underlying the pathophysiology of cardiopulmonary bypass (CPB), which led to a general improvement in patient outcomes, some aspects of CPB are controversial. These controversial aspects of CPB are related to the question of the mechanism and nature of blood delivery to the patient, for example, which blood circulation mode should be used - pulsative or non-pulsative. Object and methods. This study included 320 patients with ischemic heart disease, was conducted on basis of Heart Institute of Ministry of Health of Ukraine. It was used coronary artery bypass grafting with applying 2-3 aorto-coronary anastomoses under conditions of cardiopulmonary bypass. The average age of patients is 68.1 ± 2.9 years. Depending on the mode of flow with CPB, patients are divided into two groups: the first 152 patients using the pulsative mode; the second 168 patients with non-pulsative blood flow. CPB was performed on a System 1 (Terumo, USA) apparatus using Affinity disposable membrane oxygenators (Medtronic, USA) under conditions of moderate hypothermia (32°Ñ). Results. In patients who used non-pulsative blood flow, index of systemic vascular resistance value is significantly higher compared with patients who used pulsative blood flow. The oxygen consumption index in patients who underwent CPB with a pulsative flow at the end of artificial fibrillation was significantly higher compared to its value at the beginning of fibrillation. The level of creatinine in both study groups after 24 and 48 hours was significantly higher compared with baseline data. Conducting CPB with a non-pulsative flow was characterized by a significantly higher by 17.82% (p=0.048) creatinine level 24 hours after the operation compared with the use of pulsative blood flow, however, the value of this indicator was within the reference limits. Conclusions. Although we didnt establish any specific reliable benefits in aged and geriatric patients with CABG with a pulsative mode as compared to non-pulsative one, it is worth noting that with this blood flow mode, higher oxygen consumption and moderate changes in biochemical parameters were observed.

Background: Recent studies have reported an association between natural disasters of various kinds and ischemic heart disease (IHD). We investigated the association between Disability-adjusted life years (DALYs) due to IHD and natural disasters and aimed to assess DALYs as a quantification of the burden of IHD related to natural disasters at the global level. Methods: Country-specific data of natural disaster impacts DALYs due to IHD and socioeconomic variables were obtained from open sources over the period of 1990–2013 and 2014–2017. A population-based trend ecological design was conducted to estimate the association between trends in DALYs and natural disasters (occurrence, casualties and total damage), adjusting for socioeconomic variables. Results: Most countries have experienced increases in natural disaster occurrences and decreases in DALYs during this study period. The unadjusted correlation analysis demonstrated a positive and significant correlation between DALYs and natural disasters for females and for both sexes (R = 0.163 and 0.146, p = 0.024 and 0.043), and a marginally significant correlation for males (R = 0.128, p = 0.076). After adjusting for socioeconomic variables, multiple linear regression demonstrated independent associations between the occurrence and DALYs due to IHD for males, females and both sexes (standardized coefficients = 0.192, 0.23 and 0.187, p = 0.016, 0.004 and 0.022). Conclusions: A weak but significantly positive association between natural disaster and IHD was confirmed and quantified at the global level by this DALY metric analysis. Adaptation strategies for natural disaster responses and IHD disease burden reduction need to be developed.

Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value. Material and methods. Amino acid pools were studied by high-performance liquid chromatography in plasma of 45 patients with IHD including 20 patients with CHI and 30 healthy persons. Results. Hyperhomocysteinemia is distinctive for patients with CHI only. Changes in levels of compounds related to amino acid transport to cells (decreased content of total cysteinylglycine, increased – of total cysteine and glutathione) were seen even in absence of CHI. Increased level of serotonin and decreased – of tryptophan in plasma were observed regardless of the CHI. Conclusion. Manifestation of CHI can substantially aggravate the amino acid imbalance existing in blood plasma of patients with IHD.

Aim. To study the influence of chronic obstructive pulmonary disease (COPD) on post-operation period course in coronary heart disease (CHD) patients after coronary bypass surgery (CBG). Material and methods. Totally, 92 patients included, with CHD. Two groups were formed: 1st — 50 patients with CHD, 2nd — 42 patients with CHD and COPD. We studied the condition of ventilation via bodypletismography method, and registered oxygen consumption at rest and assessed the effectiveness of pulmonary ventilation — oxygen utilization coefficient (OUC2 , mL/L). Via the method of monofactor logistic regression analysis we calculated independent predictors of cardiovascular and respiratory complications during the nearest period of CBG. Results. After CBG the number of in-hospital complications in the 2nd group was higher than in the 1st. In 2nd group there were more prevalent respiratory failure, atrial fibrillation, cerebral function alteration. As predictor for complications after CBG was COPD (OR 2,1; CI 1,7-2,9; p=0,002). Combination of low values of the forced expiration by 1 s (FEV1) — less than 60% from normal with increase of residual volume (RV) more than 130% is significant predictor for the increase of ventilatory support (VS) (OR 2,5; CI 1,9-3,2; p=0,01). At baseline, decrease of OUC2 less than 20 mL/L is also the predictor for RS prolongation (OR 1,9; CI 1,4-2,8; p=0,003). Conclusion. COPD in CHD increases the chances of complicated clinical course of in-hospital period 2,1 times. Such specifics of baseline disorder in ventilation system as decrease FEV1 less than 60% with increase of RV more 130%, and significant decrease of effectiveness of pulmonary ventilation — OUC2 less than 20 mL/L increase chances for RS duration after CBG 2,5 and 1,9 times, respectively.

Цель исследования: оценить частоту встречаемости некоторых ключевых генов-кандидатов и их возможный вклад в развитие ишемической болезни сердца (ИБС) у пациентов г. Новосибирска и Новосибирской области. Материалы и методы. Обследован 391 пациент с ИБС и 449 условно здоровых доноров. Исследовали частоту встречаемости полиморфизмов ключевых генов системы гемостаза — F2: 20210 G > A, F5: 1691 G > A (Arg506Gln), F7: 10976 G > A (Arg353Gln), F13A1: 103G > T (Val34Leu), FGB: –455 G > A, ITGA2: 807 C > T (Phe224Phe), ITGB3: 1565 T > C (Leu33Pro), SERPINE1 (PAI-1): –675 5G > 4G и генов метаболизма фолиевой кислоты — MTHFR: 677 C > T (Ala222Val), MTHFR: 1298 A > C (Glu429Ala), MTR: 2756 A > G (Asp919Glu), MTRR: 66 A > G (Ile22Met). Результаты. При анализе не обнаружено различий в частоте встречаемости всех исследованных генетических полиморфизмов между больными ИБС и условно здоровыми донорами. Заключение. Обнаружено, что носительство мутации Лейдена повышает риск развития инфаркта миокарда (OR = 6,9) в возрасте до 55 лет., Aim: to estimate the frequency occurrence of some key genes and their possible infl uence on the development of ischemic heart disease (IHD) in patients in Novosibirsk and Novosibirsk Region. Materials and methods. We examined 391 patients with IHD and 449 relatively healthy donors. We investigated frequency of key hemostatic gene polymorphisms — F2: 20210 G > A, F5: 1691 G > A (Arg506Gln), F7: 10976 G > A (Arg353Gln), F13A1: 103G > T (Val34Leu), FGB: –455 G > A, ITGA2: 807 C > T (Phe224Phe), ITGB3: 1565 T > C (Leu33Pro), SERPINE1 (PAI-1): –675 5G > 4G and of folate metabolism genes — MTHFR: 677 C > T (Ala222Val), MTHFR: 1298 A > C (Glu429Ala), MTR: 2756 A > G (Asp919Glu), MTRR: 66 A > G (Ile22Met). Results. Analysis revealed no diff erences in frequency of all tested gene polymorphisms between patients with IHD and relatively healthy donors. Conclusion. It was found what presence of Leiden mutation increased risk of myocardial infarction (OR = 6,9) older than 55 years., №2(74) (2018)

Мета дослідження — підвищення ефективності прогнозуванняпередчасних пологів у вагітних групи ризику шляхом оптимізації діагностичних заходів.Матеріал і методи. Дослідження проводили у вагітних з удаваними переймами в терміні до 37 тижнів, які перебували на стаціонарному лікуванні. Проведено комплексне оцінювання факторів ризику розвитку передчасних пологів. Основну групу становили 40 вагітних із удаваними переймами, яким було визначено рівень фетального фібронектину в сироватці крові та в цервікальному слизу. До контрольної групи увійшли 20 вагітних із фізіологічним перебігом вагітності.Результати. Як встановило наше дослідження, у вагітних іззагрозою передчасних пологів, в яких виявлено фактори підвищеного ризику передчасних пологів, має місце достовірне ефективне визначення фетального фібронектину в сироватці крові в терміні гестації 28-30 тижнів+6 днів, а достовірне ефективне визначення фетального фібронектину в цервікальному слизу — у 22-27 тижнів+6 днів. Проте ефективність його діагностики з метою прогнозування передчасних пологів не обґрунтоване після 34 тижнів ні в сироватці, ні в цервікальному слизу, тому що ефективність його дорівнює нулю.Висновок. Прогнозування передчасних пологів у групи ризику з визначенням фетального фібронектину можливо в цервікальному слизу в терміні гестації 22-27 тижнів+6 днів та в сироватці крові в терміні гестації 28-30 тижнів+6 днів. Достовірне ефективне визначення фетального фібронектину є обґрунтуванням до госпіталізації в стаціонар і показом до призначення терапії з метою запобігання розвитку передчасних пологів., Цель исследования — повышение эффективности прогнозирования преждевременных родов у беременных группы риска путем оптимизации диагностических мероприятий.Материал и методы. Исследования проводились у беременных с мнимыми схватками в сроке до 37 недель, которые находились на стационарном лечении. Проведено комплексное оценивание факторов риска развития преждевременных родов. Основную группу составили 40 беременных с мнимыми схватками, которым был определен уровень фетального фибронектина в сыворотке крови и в цервикальной слизи. В контрольную группу вошли 20 беременных с физиологическим течением беременности. Результаты. Как установило наше исследование, у беременных с угрозой преждевременных родов, в которых выявлены факторы повышенного риска преждевременных родов, имеет место достоверное эффективное определение фетального фибронектина в сыворотке крови в сроке гестации 28-30 недель + 6 дней, а достоверное эффективное определение фетального фибронектина в цервикальной слизи — в 22-27 недель + 6 дней. Однако, эффективность его диагностики с целью прогнозирования преждевременных родов не обосновано после 34 недель ни в сыворотке, ни в цервикальной слизи, потому что эффективность его равна нулю. Вывод. Прогнозирование преждевременных родов в группе риска по определению фетального фибронектина возможно в цервикальной слизи в сроке гестации 22-27 недель + 6 дней и в сыворотке крови в сроке гестации 28-30 недель + 6 дней. Достоверное эффективное определение фетального фибронектина является обоснованием к госпитализации в стационар и показанием к назначению терапии с целью предотвращения развития преждевременных родов., Objective — to mprove the effectiveness of prediction of premature labor in pregnant women at risk group by optimizing the diagnostic measures.Materials and methods: The study involved pregnant women with false contractions in a period of up to 37 weeks. Complex assessment of risk factors of preterm births development has been done. The main group included 40 pregnant women with false contractions, in whom the level of fetal fibronectin in serum and in cervical mucus was measured. The control group included 20 pregnant women with a physiological course of pregnancy.Results: In pregnant women with high risk factors of preterm labor, determination of fetal fibronectin in serum in a gestation period of 28-30 weeks + 6 days and determination of fetal fibronectin in cervical mucus in 22-27 weeks + 6 days are reliable and effective. However, the effectiveness of its diagnosis in order to predict preterm labor after 34 weeks is zero, both in the serum and in the cervical mucus.Conclusion: The prediction of premature labor in the risk group with the determination of fetal fibronectin is possible in cervical mucus in the gestation period of 22-27 weeks + 6 days and in the serum with the gestation period of 28-30 weeks + 6 days. Effective determination of fetal fibronectin is a justification for hospitalization and an indication for prescription the therapy in order to prevent the development of premature births.

Ventrikulska tahikardija poremećaj je ritma srca frekvencije veće od 100/min. Najčešće se javlja u pacijenata koji imaju strukturnu bolest srca, a povezana je s povećanim rizikom od iznenadne srčane smrti. Poznat je i idiopatski oblik koji se javlja na strukturno zdravom srcu. Gledajući etiološki ishemijska bolest srca svakako je najčešći uzrok njezinog nastanka. S obzirom na izgled QRS kompleksa razlikujemo monomorfni i polimorfni oblik. Tri glavna simptoma kojima se prezentiraju pacijenti i koji trebaju daljnju obradu jesu palpitacije, presinkopa i sinkopa. 12-kanalni EKG prva je neinvazivna dijagnostička metoda u evaluaciji ovog poremećaja, a na raspolaganju su nam i ostale neinvazivne kao i invazivne metode. Važno je tražiti etiološku podlogu nastanka aritmije kako bi što ispravnije mogli liječiti bolesnike. Današnja terapija VT-a uključuje i medikamentoznu terapiju antiaritmijskim lijekovima, ali i nefarmakološke mjere poput ugradnje kardioverterskog-defibrilatora te katetersku i kiruršku ablaciju. Odgovarajuća terapija može značajno poboljšati prognozu u odabranih pacijenata. Uz zbrinjavanje akutno nastale ventrikulske tahikardije, važno je prevenirati ponovno javljanje iste i time smanjiti rizik od iznenadne srčane smrti., Ventricular tachycardia is a heart rhythm disorder frequency greater than 100/min. It most commonly occurs in patients with structural heart disease and can be associated with an increased risk of sudden death. There is also a form of idiopathic VT which can occur in the absence of structural heart disease. The most common cause of VT is certainly ishemic heart disease. According to QRS complex, we distinguish monomorphic and polimorphic form. Palpitations, presyncope and syncope are the three most important symptoms that require further investigation. A standard 12-lead ECG is the first non-invasive diagnostic method we can use, but there are also other non-invasive and invasive diagnostic methods. It is important to find out about the etiology of arrhythmia to properly treat patients. Nowadays, the VT therapy includes both medicamentous and non-pharmacological therapy such as implantable cardioverter-defibrillator, catheter and surgical ablation. The appropriate treatment can significantly improve the prognosis in selected patients. The VT treatment involves both emergent management and prevention of recurrence so we could reduce the risk of sudden death.

This article presents an analysis of 4214 Holter monitoring of heart rate and comparative characteristics of heart rate variability in patients with cardiovascular disease and patients with high and very high risk of cardiovascular events on a scale SCORE and existing phenomenon of turbulence heart rate in healthy people., В статье представлен анализ 4214 холтеровских мониторирований сердечного ритма и сравнительная характеристика показателей вариабельности сердечного ритма у пациентов с сердечно-сосудистым заболеванием и пациентов с высоким и очень высоким риском возникновения сердечно-сосудистых событий по шкале SCORE и имеющимся явлением турбулентности сердечного ритма с показателями практически здоровых лиц., У статті представлений аналіз результатів 4214 холтерівських моніторувань серцевого ритму та порівняльна характеристика показників варіабельності серцевого ритму серед пацієнтів із серцево-судинним захворюванням та пацієнтів із високим та дуже високим ризиком виникнення серцево-судинних подій за шкалою SCORE, та наявним явищем турбулентності серцевого ритму з показниками практично здорових осіб.