1. Clinical Application and Drug-Use-Guidance Value of Metagenomic Next-Generation Sequencing in Central Nervous System Infection
- Author
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Lin, Ke, Zhang, Hao-Cheng, Zhang, Yi, Zhou, Yang, Fu, Zhang-Fan, Wang, Hong-Yu, Zhao, Yuan-Han, Qiu, Chao, Fan, Ming-Xiang, Song, Jie-Yu, Ai, Jing-Wen, and Zhang, Wen-Hong
- Subjects
Original Article - Abstract
Background Timely and precise etiology diagnosis is crucial for optimized medication regimens and better prognosis in central nervous system infections (CNS infections). We aimed to analyze the impact of mNGS tests on the management of patients with CNS infections. Methods We conducted a single-center retrospective cohort study to analyze the value of mNGS in clinical application. Three hundred sixty-nine patients with a specific CNS infection diagnosis were enrolled, and their clinical data were collected. CDI and DDI were defined in our study to describe the intensity of drug use in different groups. We also used LOH and mRS to evaluate whether the application of mNGS could benefit CNS infection patients. Results mNGS reported a 91.67% sensitivity in culture-positive patients and an 88.24% specificity compared with the final diagnoses. Patients performed with the mNGS test had less drug use, both total (58.77 vs. 81.18) and daily (22.6 vs. 28.12, p
- Published
- 2021