198 results on '"Yongjun Yang"'
Search Results
2. Effective alleviation of Cd stress to microbial communities in mining reclamation soils by thiourea-modified biochar amendment
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Yanfeng ZHU, Jing MA, Fu CHEN, Ruilian YU, Gongren HU, and Yongjun YANG
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Soil Science - Published
- 2022
3. Assessing the inspirational value of cultural ecosystem services based on the Chinese poetry
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Yunlong Gong, Peichao Dai, Yongjun Yang, Shaoliang Zhang, and Huping Hou
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Service (business) ,Index (economics) ,Ecology ,business.industry ,Environmental resource management ,Ecosystem services ,Diversity index ,Geography ,Xuzhou ,Value (economics) ,Chinese poetry ,China ,business ,Ecology, Evolution, Behavior and Systematics - Abstract
Inspiration is an essential service within cultural ecosystem services. However, there is little research on the inspirational value due to the limitations of the available data. A large number of Chinese poetries mention a variety of ecological elements that inspired poets' creativity. This collection of poetries is the embodiment of the inspirational cultural ecosystem service and provides a new data source for evaluating the inspirational value of cultural ecosystem services. We established the ecological element diversity index and inspirational value index model to evaluate inspirational service. We investigated the poetry from the West Lake in Hangzhou City and the Yunlong Lake in Xuzhou City, China. The results showed the following: (1) The calculation of the ecological elements yielded four levels. The value of the first level was more than four times that of the fourth level. (2) The inspirational value index of plants is the highest in the classification of the ecological elements, followed by meteorological elements, animals, bodies of water, and topography. (3) Among the specific ecological elements, the wood-inspired value index is the highest, 108,855.24, followed by wind and birds, which are 100,665.80 and 89,305.85, respectively, and 71.05% of the value index is between 0 and 10,000. (4) The inspirational value index of the West Lake is 7076.13, and it is 17.08 for the Yunlong Lake. Therefore, the research method of this study provides a new way to evaluate the inspirational value of cultural ecosystem services.
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- 2022
4. 5G-Enabled Medical Data Transmission in Mobile Hospital Systems
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Parfait Ifede Tebe, Guangjun Wen, Jian Li, Yongjun Yang, Wenhong Tian, Jing Chong, and Wenjun Zhang
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Computer Networks and Communications ,Hardware and Architecture ,Signal Processing ,Computer Science Applications ,Information Systems - Published
- 2022
5. Soil microbes-mediated enzymes promoted the secondary succession in post-mining plantations on the Loess Plateau, China
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Qi Zhang, Jing Ma, Alejandro Gonzalez-Ollauri, Yongjun Yang, and Fu Chen
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Ecology ,Soil Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
6. Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19
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Zhang, Zuming Xiong, Yongjun Yang, Wenxin Li, Yirong Lin, Wei Huang, and Sen
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digestive system cancers ,COVID-19 ,common biomarkers ,pathogenesis ,diagnosis ,prognosis - Abstract
Digestive system cancer and COVID-19 significantly affect the digestive system, but the mechanism of interaction between COVID-19 and the digestive system cancers has not been fully elucidated. We downloaded the gene expression of COVID-19 and seven digestive system cancers (oral, esophageal, gastric, colorectal, hepatocellular, bile duct, pancreatic) from GEO and identified hub differentially expressed genes. Multiple verifications, diagnostic efficacy, prognostic analysis, functional enrichment and related transcription factors of hub genes were explored. We identified 23 common DEGs for subsequent analysis. CytoHubba identified nine hub genes (CCNA2, CCNB1, CDKN3, ECT2, KIF14, KIF20A, KIF4A, NEK2, TTK). TCGA and GEO data validated the expression and excellent diagnostic and prognostic ability of hub genes. Functional analysis revealed that the processes of cell division and the cell cycle were essential in COVID-19 and digestive system cancers. Furthermore, six related transcription factors (E2F1, E2F3, E2F4, MYC, TP53, YBX1) were involved in hub gene regulation. Via in vitro experiments, CCNA2, CCNB1, and MYC expression was verified in 25 colorectal cancer tissue pairs. Our study revealed the key biomarks and common pathogenesis of digestive system cancers and COVID-19. These may provide new ideas for further mechanistic research.
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- 2023
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7. Field survey and analysis of water flux and salinity gradients considering the effects of sea ice coverage and rubber dam: a case study of the Liao River Estuary, China
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Zhanming Hu, Kaiyuan Guo, Yongjun Yang, and Mingliang Zhang
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Global and Planetary Change ,Ocean Engineering ,Aquatic Science ,Oceanography ,Water Science and Technology - Abstract
Predicting net river fluxes is important to promote good water quality, maritime transport, and water exchange in estuaries. However, few studies have observed and evaluated net water fluxes to estuaries under complex conditions. This study used advanced survey techniques to obtain high-frequency monitoring data of cross-sectional current velocity, water level, and salinity in the Liao River Estuary (LRE) from 2017 to 2020. The net water flux into the sea was computed based on field data and the impacts of the rubber dam and sea ice cover on water flux and salinity processes were analyzed in the study region. In the Liao River Station (LRS), the fluctuations of water level and discharge were not obvious in winter due to the sea ice cover. There were significant seasonal and inter-annual changes in water fluxes due to variability in river discharge and tidal oscillations. The results also showed that the net water flux into the sea from the LRS was positive in wet season, and greater during ebb tides than flood tides. The net water fluxes in the normal and dry seasons were mostly negative due to the influence of tides, indicating that the annual runoff from the Liao River fluctuated greatly throughout the year. The water flux in the LRS was more suitable for representing water flux into the sea than the Liujianfang Hydrometric Station (LHS) in the LRE. The impacts of the rubber dam and Panshan Sluice on water fluxes to the sea were both significant. Lower salinity in the study area coincided mostly with height water fluxes to the sea and periods when the rubber dam was raised. This study results provide us new insights to measure the water flux into sea under the condition of ice cover in the tidal reach of estuary and the method can be used for water flux observation for other estuaries.
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- 2023
8. Airport terminal area visualization decision system research
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qishufeng qishufeng, Hong Wang Hong Wang, Wei Quan Wei Quan, Ming Chang Ming Chang, Minna Ge Minna Ge, Yongjun yang Yongjun yang, and Yong Guo Yong Guo
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- 2022
9. Precise diagnosis and treatment of non-muscle invasive bladder cancer - A clinical perspective
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Yongjun Yang, Chen Wang, Zonglin Li, Qiang Lu, and Yuanwei Li
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Cancer Research ,Oncology - Abstract
According to the guidelines, transurethral resection of bladder tumor (TURBT) followed by intravesical therapy remains the standard strategy for the management of non-muscle invasive bladder cancer (NMIBC). However, even if patients receive standard strategy, the risk of postoperative recurrence and progression is high. From the clinical perspective, the standard strategy needs to be optimized and improved. Compared to conventional TURBT, the technique of en bloc resection of bladder tumor (ERBT) removes the tumor tissue in one piece, thus following the principles of cancer surgery. Meanwhile, the integrity and spatial orientation of tumor tissue is protected during the operation, which is helpful for pathologists to make accurate histopathological analysis. Then, urologists can make a postoperative individualized treatment plan based on the patient’s clinical characteristics and histopathological results. To date, there is no strong evidence that NMIBC patients treated with ERBT achieve better oncological prognosis, which indicates that ERBT alone does not yet improve patient outcomes. With the development of enhanced imaging technology and proteogenomics technology, en bloc resection combined with these technologies will make it possible to achieve precise diagnosis and treatment of bladder cancer. In this review, the authors analyze the current existing shortcomings of en bloc resection and points out its future direction, in order to promote continuous optimization of the management strategy of bladder cancer.
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- 2023
10. CD47-targeted optical molecular imaging and near-infrared photoimmunotherapy in the detection and treatment of bladder cancer
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Yongjun Yang, Xiaoting Yan, Jiawei Li, Chao Liu, and Xiaofeng Yang
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Cancer Research ,photoimmunotherapy ,Oncology ,optical molecular imaging ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,bladder cancer ,Molecular Medicine ,Original Article ,Pharmacology (medical) ,CD47 ,residual tumor ,RC254-282 - Abstract
Transurethral resection of bladder tumor (TURBT) followed by intravesical therapy remains the most effective strategy for the management of non-muscle-invasive bladder cancer worldwide. TURBT has two purposes: to remove all visible tumors and to obtain tumor specimens for histopathological analysis. However, the detection of flat and small malignant lesions under white-light cystoscopy is extremely challenging, and residual lesions are still the main reason for the high recurrence rate of bladder cancer. We hypothesized that visual enhancement of malignant lesions using targeted optical molecular imaging could potentially highlight residual tumors in the bladder during surgery, and near-infrared photoimmunotherapy (NIR-PIT) could kill exfoliated cancer cells and residual tumors. A mouse model of complete or partial bladder tumor resection was established under the guidance of optical molecular imaging mediated by indocyanine green and anti-CD47-Alexa Fluor 790, respectively. Once the tumor recurred, mouse model received repeated CD47-targeted NIR-PIT. After complete resection, there was no tumor recurrence. Furthermore, the growth rate of recurrent tumor decreased significantly after repeated NIR-PIT. Therefore, CD47-targeted optical molecular imaging can potentially assist urologists to detect and remove all tumors, and repeated NIR-PIT shows the potential to reduce tumor recurrence rates and inhibit the growth of recurrent tumor., Graphical abstract, This study aimed at researching the role of CD47-targeted optical molecular imaging and near-infrared photoimmunotherapy (NIR-PIT) in the management of bladder cancer. The authors showed that CD47-targeted optical molecular imaging can potentially help urologists detect and remove all tumors, and NIR-PIT shows the potential to inhibit tumor growth.
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- 2022
11. Bias-Induced Point Auto-Encoder and Comparative Analysis of Point Encoder-Decoder Combinations
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YongJun Yang, WENCAN CHENG, and SUKHAN LEE
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General Computer Science ,General Engineering ,General Materials Science ,Electrical and Electronic Engineering - Published
- 2022
12. Detecting long-term effects of mining-induced ground deformation on plant succession in semi-arid areas using a cellular automata model
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Jiaxin Mi, Huping Hou, Shaoliang Zhang, Yifei Hua, Yongjun Yang, Yuanli Zhu, and Zhongyi Ding
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Ecology ,General Decision Sciences ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
13. Dynamic and high-speed measurement system for blade tip clearance of engine with optical comb
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Jibo Han, Yu Bai, Linjie Lv, Tengfei Wu, Yahui Wu, Zhang Cao, and Yongjun Yang
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Materials Science (miscellaneous) ,Biophysics ,General Physics and Astronomy ,Physical and Theoretical Chemistry ,Mathematical Physics - Abstract
For blade tip clearance measurement, the optical measurement method has the characteristics of high precision, anti-electromagnetic interference, and non-contact measurement. A dynamic and high-speed blade tip clearance measurement system based on time stretch dispersive Fourier transform with the optical comb is proposed and demonstrated. The dynamic experiments are designed to verify the accuracy of the system. The results show that the measuring speed is up to 17.6 MHz and the measurement errors are less than 1 μm under dynamic conditions. The experiments prove that the system has the advantages of high measurement accuracy, high speed, and good repeatability. It can provide a new tool for engine health monitoring.
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- 2022
14. Research on Ecosystem Strategy of Provincial Power Grid Company
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Meng Yang, XiChao Du, YongJun Yang, PengPeng Yang, XianJie Wu, and YiXue Yang
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- 2022
15. Detecting long-term effects of mining-induced ground deformation on plant patterns in semi-arid areas using a cellular automata model
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Jiaxin Mi, Shaoliang Zhang, Huping Hou, Yifei Hua, Yongjun Yang, and Zhongyi Ding
- Abstract
Contexts Mining-induced ground deformation has various effects on different plant communities. However, little is known about the effects of ground deformation on plant patterns after spontaneous succession, and there is currently no quantitative approach to the detection of these long-term effects. Objectives A plant community succession model (PCSM) based on cellular automate was developed, and the 30-year plant succession within a subsidence area in the Yungang mining area in China under mining and non-mining scenarios, as well as under two sets of initial conditions (plant-covered and bare), were simulated and compared. Methods The normalized mean square error (NMSE) was applied to test the accuracy of the PCSM and to reveal the effects of ground deformation at the patch scale, which was 0.06–0.59 for simulated and observed plant patterns. Six landscape indicators (contagion index (CONTAG), patch cohesion index (COHESION), landscape division (DIVISION), Shannon’s diversity index (SHDI), Shannon’s evenness index (SHEI), and aggregation index (AI)) were calculated for the mining and non-mining scenarios and compared to reveal the effects at the landscape scale. Results The results show that the DIVISION, SHDI, and SHEI were significantly higher in the mining scenario than in the non-mining scenario under plant-covered conditions; while the DIVISION was greater for the mining scenario than for the non-mining scenario, indicating that the ground deformation resulted in a loose, separated, and mixed plant pattern. The dynamics of the plant coverages and patterns in the two scenarios reflect the negative and positive effects of ground deformation on the tree and shrub communities, respectively. In terms of the shrub and tree communities, the NMSEs fluctuated at a high level under bare conditions, especially at the patch scale of 10 × 10 m, for which it was maintained at >0.5. Conclusion Overall, the mining-induced ground deformation chronically influenced the plant succession by limiting tree communities and promoting shrub communities, and it led to a heterogenous plant pattern. The results of this research provide a reference for detecting the long-term effects of mining-induced ground deformation on plant patterns, and they also provide insights into the effects of underground mining on different plant communities.
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- 2022
16. Change in Landscape Multifunctionality and Its Trade-off–Synergy Relationship in Mined Land
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Yiyan Zhang, Dong Zhao, Huping Hou, Yongjun Yang, Shi An, Zanxu Chen, and Shaoliang Zhang
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Global and Planetary Change ,Ecology ,Nature and Landscape Conservation ,mined land ,ecological restoration ,InVEST model ,landscape multifunctionality - Abstract
Mining often generates large amounts of inefficiently used land. Clarifying the multifunctional characteristics of mined land and its spatial and temporal evolution is important to environmental protection and promoting the economic and social benefits of mined areas. This article analyzed the conditions of mined land in Jiawang, Jiangsu province, China. The InVEST model was used to assess landscape functions, including those related to water and soil conservation, productivity, habitats, carrying capacity, recreation, and carbon sequestration, to explore the multifunctional changes and trade-off–synergy relationships of the landscape from 2005 to 2020. The results show that (1) ecological restoration of the mined land significantly improved the regional landscape multifunctionality during the study period, with each function enhanced more obviously after restoration was completed in 2012, and (2) the trade-offs and synergistic relationships for landscape multifunctionality varied during the study period because the time series evolved; some trade-offs gradually transformed into synergistic relationships. This study establishes a set of effective systems useful in evaluating the multifunctionality of mined land, and initially evaluated the trade-off–synergistic relationships among eight landscape functions. This will provide ideas supporting the management and restoration of mined land and help in the formulation of spatial planning strategies for ecological restoration.
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- 2022
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17. Research on the application of square table grounding grid based on GASP calculation
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Anbang Xie, Xiaofan Song, and Yongjun Yang
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- 2022
18. Affinity-Guided Isolation and Identification of Procyanidin B2 from Mangosteen (Garcinia mangostana L.) Rinds and its In Vitro LPS Binding and Neutralization Activities
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Yongjun Yang, Xinchuan Zheng, Qian Chen, and Yongling Lu
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Lipopolysaccharides ,food.ingredient ,Lipopolysaccharide ,Plant Extracts ,Catechin ,In vitro ,Neutralization ,Garcinia mangostana ,Hydrophobic effect ,chemistry.chemical_compound ,food ,chemistry ,Biochemistry ,Chemistry (miscellaneous) ,Fruit ,Biflavonoids ,LPS binding ,Proanthocyanidins ,lipids (amino acids, peptides, and proteins) ,Tumor necrosis factor alpha ,Procyanidin B2 ,Food Science - Abstract
Garcinia mangostana L. (mangosteen) is a tropical fruit that has been used for medicinal purposes in Southeast Asia for centuries. With an interest in its applications to treat infection, we sought to investigate the bioactive constituents of mangosteen and identified the phenolic compound procyanidin B2 from the mangosteen pericarp by examining lipopolysaccharide (LPS) binding capacity. The LPS binding and neutralization activities of procyanidin B2 were determined by a combination of biophysical and in silico techniques. The affinity of procyanidin B2 to LPS was 1.61 × 10–5 M. Procyanidin B2 significantly neutralized LPS and selectively inhibited the LPS-induced release of tumor necrosis factor (TNF)-α from RAW264.7 cells in a dose-dependent manner. Binding thermodynamics revealed favorable hydrogen bonding and hydrophobic interactions between procyanidin B2 and LPS. Molecular simulations suggested that hydrogen bonding and hydrophobic interactions were involved in the binding process. These findings have, for the first time, shed light on the anti-inflammatory properties of procyanidin B2 through LPS binding and neutralization and provided a promising lead for the development of antiendotoxin agents.
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- 2021
19. CD40L/CD40 Regulates Adipokines and Cytokines by H3K4me3 Modification in Epicardial Adipocytes
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Ming Yuan, Bin Wu, Yongjun Yang, Liang Zhang, and Huan Wang
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Leptin ,Male ,CD40 Ligand ,Adipokine ,Coronary Artery Disease ,Methylation ,Histones ,Adipokines ,Downregulation and upregulation ,Plasminogen Activator Inhibitor 1 ,Adipocytes ,medicine ,Humans ,Gene silencing ,CD40 Antigens ,Promoter Regions, Genetic ,Cells, Cultured ,Chemokine CCL2 ,Aged ,Pharmacology ,Messenger RNA ,Interleukin-6 ,Chemistry ,Monocyte ,hemic and immune systems ,Histone-Lysine N-Methyltransferase ,Middle Aged ,Cell biology ,medicine.anatomical_structure ,Case-Control Studies ,Cytokines ,Female ,Ectopic expression ,Cytokine secretion ,Cardiology and Cardiovascular Medicine ,Pericardium ,Protein Processing, Post-Translational ,Plasminogen activator ,Myeloid-Lymphoid Leukemia Protein - Abstract
Epicardial adipose tissue (EAT) dysfunction mediates chronic inflammation by regulating inflammation-related adipokines and cytokines, and it further promotes coronary artery disease (CAD) development. CD40L/CD40 is involved in multiple inflammatory pathways that contribute to various pathophysiological processes. However, the function of CD40L/CD40 in the expression and production of adipokines and cytokines in epicardial adipocytes remains unclear. The purpose of the present study was to explore the role and underlying mechanisms of CD40L/CD40 in adipokine and cytokine expression and production. We isolated adipocytes from EAT tissues of CAD and non-CAD patients. We noticed that CD40 was dramatically increased in EAT tissues of CAD patients. Loss-of-function and gain-of-function studies were performed. The results showed that CD40 silencing reduced recombinant CD40 ligand (rCD40L)-induced upregulation of plasminogen activator inhibitor-1, leptin, interleukin-6, and monocyte chemotactic protein-1 messenger RNA levels and secretion. Overexpression of CD40 displayed the opposite results. In addition, rCD40L triggered mixed lineage leukemia protein-1 (MLL1) expression both in messenger RNA and protein levels. CD40 depletion apparently blocked MLL1 expression, whereas gain of function of CD40 resulted in augmentation of MLL1 levels. Interestingly, chromatin immunoprecipitation-quantitative real-time polymerase chain reaction analysis revealed that CD40 elimination dampened histone H3 lysine 4 trimethylation enrichment at plasminogen activator inhibitor-1, leptin, interleukin-6, and monocyte chemotactic protein-1 promoter regions in the presence of rCD40L. The reverse pattern was observed upon ectopic expression of CD40. Most important, MLL1 silencing effectively reversed the promotive effects of CD40 on adipokine and cytokine secretion. Taken together, our findings suggest that CD40L/CD40 regulates adipokine and cytokine expression by H3 lysine 4 trimethylation modification in adipocytes.
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- 2021
20. Intracellular bacteriolysis contributes to pathogenicity ofiStaphylococcus aureus/iby exacerbating AIM2-mediated inflammation and necroptosis
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Shiyuan Feng, Yongjun Yang, Zhenzhen Liu, Wei Chen, Chongtao Du, Guiqiu Hu, Shuixing Yu, Peixuan Song, and Jinfeng Miao
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Microbiology (medical) ,Inflammation ,Staphylococcus aureus ,Virulence ,Inflammasomes ,Immunology ,Staphylococcal Infections ,Microbiology ,DNA-Binding Proteins ,Infectious Diseases ,Bacteriolysis ,Necroptosis ,Humans ,Parasitology - Abstract
iStaphylococcus aureus/ican survive within phagocytes. Indeed, we confirm in this study that approximately 10% of population persists in macrophages duringiS. aureus/iinfection, while the rest are eliminated due to bacteriolysis, which is of particular interest to us. Herein, we observe that the bacteriolysis is an early event accompanied by macrophage death duringiS. aureus/iinfection. Furthermore, the cell death is significantly accelerated following increased intracellular bacteriolysis, indicating that intracellular bacteriolysis induces cell death. Subsequently, we establish that the cell death is not apoptosis or pyroptosis, but AIM2-mediated necroptosis, accompanied by AIM2 inflammasome activation. This finding challenges the classical model that the cell death that accompanies inflammasome activation is always pyroptosis. In addition, we observe that the apoptosis-associated genes are highly inhibited duringiS. aureus/iinfection. Finally, we establish in vivo that increased bacteriolysis significantly enhancesiS. aureus/ipathogenicity by promoting its dissemination to kidney and leading to an inflammatory cytokine storm in AIM2-mediated manner. Collectively, our data demonstrate that bacteriolysis is detrimental when triggered in excess and its side effect is mediated by AIM2. Meanwhile, we propose a potential immune manipulation strategy by whichiS. aureus/isacrifices the minority to trigger a limited necroptosis, thereby releasing signals from dead cells to inhibit apoptosis and other anti-inflammatory cascades of live cells, eventually surviving within host cells and establishing infection.
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- 2022
21. Effects of Different Ratios of Carbohydrate-Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats
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Yongjun Yang, Sen Su, Yong Zhang, Dan Wu, Chao Wang, Yan Wei, and Xi Peng
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Nutrition and Dietetics ,Enteral Nutrition ,Glucose ,Body Weight ,Carbohydrates ,Insulins ,Animals ,burns ,carbohydrate–fat ratio ,enteral nutrition ,hypermetabolism ,organ damage ,Burns ,Food Science ,Rats - Abstract
(1) Background: Nutritional support is one of the most important cornerstones in the management of patients with severe burns, but the carbohydrate-to-fat ratios in burn nutrition therapy remain highly controversial. In this study, we aimed to discuss the effects of different ratios of carbohydrate–fat through enteral nutrition on the metabolic changes and organ damage in burned rats. (2) Methods: Twenty-four burned rats were randomly divided into 5%, 10%, 20% and 30% fat nutritional groups. REE and body weight were measured individually for each rat daily. Then, 75% of REE was given in the first week after burns, and the full dose was given in the second week. Glucose tolerance of the rats was measured on days 1, 3, 7, 10 and 14. Blood biochemistry analysis and organ damage analysis were performed after 7 and 14 days of nutritional therapy, and nuclear magnetic resonance (NMR) and insulin content analysis were performed after 14 days. (3) Results: NMR spectra showed significant differences of glucose, lipid and amino acid metabolic pathways. The energy expenditure increased, and body weight decreased significantly after burn injury, with larger change in the 20%, 5% and 30% fat groups, and minimal change in the 10% fat group. The obvious changes in the level of plasma protein, glucose, lipids and insulin, as well as the organ damage, were in the 30%, 20% and 5% fat groups. In relative terms, the 10% fat group showed the least variation and was closest to normal group. (4) Conclusion: Lower fat intake is beneficial to maintaining metabolic stability and lessening organ damage after burns, but percentage of fat supply should not be less than 10% in burned rats.
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- 2022
22. Remote Patients Monitoring and Pretreatment in 5G-Based Mobile Hospital Systems
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Parfait I. Tebe, Jing Chong, Wenjun Zhang, Yongjun Yang, Wenhong Tian, and Guangjun Wen
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- 2022
23. Transfer of metal element in soil plant chicken food chain: health risk assessment
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Jawaher Alkahtani, Humayun Bashir, Ifra Saleem Malik, Ijaz Rasool Noorka, Asma Ashfaq, Zafar Iqbal Khan, Mohamed Soliman Elshikh, Zille Huma, Mudassra Munir, Sonaina Nazar, Razia Sultana, Fu Chen, Jing Ma, Kafeel Ahmad, and Yongjun Yang
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Irrigation ,animal structures ,business.industry ,Health, Toxicology and Mutagenesis ,Potassium ,food and beverages ,Sewage ,chemistry.chemical_element ,General Medicine ,010501 environmental sciences ,Biology ,01 natural sciences ,Pollution ,Animal science ,Nutrient ,chemistry ,Shoot ,Environmental Chemistry ,Ecotoxicology ,business ,Gizzard ,Groundwater ,0105 earth and related environmental sciences - Abstract
This investigation was done for the assurance of potassium amassing in four assortments of maize (grains, shoot and root), soil, and water and in seven tissues of chickens (kidney, liver, heart, bone, gizzard, breast meat). The analysis of variance showed significant differences for potassium concentration in water in all sources of water; however, the season and variety significantly influenced the quantity of potassium in cereals. The corn varieties MMRI, Sadaf, and Pearl behaved differently when treated with water from various sources. Water taken from sewage had a higher concentration of potassium compared to canal and groundwater that is why the maize plants irrigated with this water had a higher grouping. Data regarding potassium concentration in different body parts of chicken showed that season and treatment have a significant effect on the potassium concentration in chicken organs. The variety was non-significant for the potassium concentration only in the bone. Season × Variety interaction was only significant in blood, meat heart, and gizzard. Season × Treatment and Variety × Treatment interactions were significant in the heart, kidney, and gizzard. The potassium contents were higher in the chicken body parts that were reared on grains irrigated with sewage water as compared to other groups. The potassium contents were higher in the chicken meat (96.23 ± 0.00) reared on grains of the Pearl variety raised with the sewage water. In a nutshell, the irrigation of grains with sewage water led to accumulation of nutrients greater than those irrigated with ground or canal water.
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- 2021
24. Recent Advances in the Catalytic Hydroconversion of 5-Hydroxymethylfurfural to Valuable Diols
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Zexing Huang, Jianhua Wang, Jing Lei, Wenguang Zhao, Hao Chen, Yongjun Yang, Qiong Xu, and Xianxiang Liu
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General Chemistry - Abstract
Biomass, a globally available resource, is a promising alternative feedstock for fossil fuels, especially considering the current energy crisis and pollution. Biomass-derived diols, such as 2,5-bis(hydroxymethyl)furan, 2,5-bis(hydroxymethyl)-tetrahydrofuran, and 1,6-hexanediol, are a significant class of monomers in the polyester industry. Therefore, the catalytic conversion of biomass to valuable diols has received extensive research attention in the field of biomass conversion and is a crucial factor in determining the development of the polyester industry. 5-Hydroxymethylfurfural (HMF) is an important biomass-derived compound with a C6-furanic framework. The hydroconversion of HMF into diols has the advantages of being simple to operate, inexpensive, environmentally friendly, safe, and reliable. Therefore, in the field of diol synthesis, this method is regarded as a promising approach with significant industrialization potential. This review summarizes recent advances in diol formation, discusses the roles of catalysts in the hydroconversion process, highlights the reaction mechanisms associated with the specificities of each active center, and provides an outlook on the challenges and opportunities associated with the research on biomass-derived diol synthesis.
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- 2022
25. The digital transformation evaluation system of power grid enterprises under the guidance of high quality is constructed
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Xichao Du, Man Jin, and Yongjun Yang
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- 2022
26. Evaluation of toxicity potential of cobalt in wheat irrigated with wastewater: health risk implications for public
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Asma Ashfaq, Humayun Bashir, Shehzadi Mahpara, Kafeel Ahmad, Zafar Iqbal Khan, Yunus Dogan, Ilker Ugulu, Ifra Saleem Malik, Jing Ma, Muhammad Nadeem, Kinza Wajid, Yongjun Yang, Asma Zafar, Fu Chen, and Mudasra Munir
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Irrigation ,Agricultural Irrigation ,Health, Toxicology and Mutagenesis ,chemistry.chemical_element ,Wastewater ,010501 environmental sciences ,01 natural sciences ,Toxicology ,Soil ,Metals, Heavy ,Biomonitoring ,Soil Pollutants ,Environmental Chemistry ,Ecotoxicology ,Pakistan ,Triticum ,0105 earth and related environmental sciences ,business.industry ,food and beverages ,Cobalt ,General Medicine ,Food safety ,Pollution ,chemistry ,Shoot ,Environmental science ,business ,Cropping ,Environmental Monitoring - Abstract
The use of wastewater in irrigation weakens the beneficial properties of the soil and leads to a threat to food safety standards. The present research was designed to explore the cobalt toxicity associated with the ingestion of wastewater irrigated wheat. Wheat plants of five different varieties were collected from 7 different sites of Punjab, Pakistan, which were irrigated with three different sources of water. The sampling was done in two cropping years. The cobalt values in water, soil and wheat samples (root, shoot, grain) ranged from 0.46 to 1.24 mg/l, 0.15 to 1.20, 0.29 to 1.30, 0.08 to 0.76 and 0.12 to 0.57 mg/kg, respectively. All the water samples showed high cobalt concentration than the maximum permissible value. However, all the soil and wheat plant samples were found within the maximum allowable range. The high cobalt concentration in irrigating water showed that the continuous usage of such type of water may lead to cobalt toxicity in living organisms with the passage of time and may results in severe health risks.
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- 2021
27. Beam Shaping by a Magnetic Fluid Deformable Mirror With Curved Trajectory for Optical Tweezer System
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Dziki Mbemba, Xiang Wei, Suresh Sivanandam, Zhizheng Wu, Yongjun Yang, Azhar Iqbal, and Feng Li
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Wavefront ,Physics ,Bessel beam ,General Computer Science ,business.industry ,General Engineering ,Physics::Optics ,Wavefront sensor ,beam shaping ,Deformable mirror ,magnetic fluid deformable mirror ,TK1-9971 ,Axicon ,optical tweezer ,Optics ,Optical tweezers ,Reflection (physics) ,General Materials Science ,Electrical engineering. Electronics. Nuclear engineering ,business ,Adaptive optics ,Beam (structure) - Abstract
This article describes a novel optical tweezer system which utilizes a magnetic fluid deformable mirror (MFDM) with a wavefront sensor (WFS) and controller to produce a curved Bessel beam for manipulating an optically trapped microparticle. The MFDM is proposed to control the wavefront phase of the laser beam since it offers the ability to produce a nearly perfect axicon in reflection. The working principle of the MFDM and its modeling and design processes are introduced. A decentralized control method is presented for the MFDM to generate the desired mirror surface shape, combing an axicon and an adjustable compensation phase profile that transforms the incident beam into a self-accelerating Bessel-like beam with curved trajectory. Using a prototype MFDM, an experimental optical tweezer system is set up to verify this optical micromanipulation method. The experimental results show the effectiveness of the proposed technique for the manipulation of optically trapped microparticles.
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- 2021
28. Glutamine promotes O-GlcNAcylation of G6PD and inhibits AGR2 S-glutathionylation to maintain the intestinal mucus barrier in burned septic mice
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Dan, Wu, Sen, Su, Xule, Zha, Yan, Wei, Gang, Yang, Qianying, Huang, Yongjun, Yang, Lin, Xia, Shijun, Fan, and Xi, Peng
- Subjects
Organic Chemistry ,Clinical Biochemistry ,Biochemistry - Abstract
Mucus forms the first line of defence of the intestinal mucosa barrier, and mucin is its core component. Glutamine is a vital energy substance for goblet cells; it can promote mucus synthesis and alleviate damage to the intestinal mucus barrier after burn injury, but its mechanism is not fully understood. This study focused on the molecular mechanisms underlying the effects of glutamine on the synthesis and modification of mucin 2 (MUC2) by using animal and cellular models of burn sepsis. We found that anterior gradient-2 (AGR2) plays a key role in the posttranslational modification of MUC2. Oxidative stress induced by burn sepsis enhanced the S-glutathionylation of AGR2, interfered with the processing and modification of MUC2 precursors by AGR2 and blocked the synthesis of mature MUC2. Further studies revealed that NADPH, catalysed by glucose-6-phosphate dehydrogenase (G6PD), is a key molecule in inhibiting oxidative stress and regulating AGR2 activity. Glutamine promotes O-linked N-acetylglucosamine (O-GlcNAc) modification of G6PD via the hexosamine pathway, which facilitates G6PD homodimer formation and increases NADPH synthesis, thereby inhibiting AGR2 S-glutathionylation and promoting MUC2 maturation, ultimately reducing damage to the intestinal mucus barrier after burn sepsis. Overall, we have demonstrated that the central mechanisms of glutamine in promoting MUC2 maturation and maintaining the intestinal mucus barrier are the enhancement of G6PD glycosylation and inhibition of AGR2 S-glutathionylation.
- Published
- 2023
29. Feature extraction of ultrasonic guided wave weld detection based on group sparse wavelet transform with tunable Q-factor
- Author
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Yongjun Yang, Jiankang Zhong, Aisong Qin, Hanling Mao, Hanying Mao, Zhengfeng Huang, Xinxin Li, and Yongchuan Lin
- Subjects
Applied Mathematics ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Instrumentation - Published
- 2023
30. The long‐term effects of underground mining on the growth of tree, shrub, and herb communities in arid and semiarid areas in China
- Author
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Huping Hou, Yifei Hua, Yongjun Yang, Zanxu Chen, Jiaxin Mi, Simit Raval, and Shaoliang Zhang
- Subjects
food.ingredient ,Underground mining (soft rock) ,ved/biology ,Agroforestry ,ved/biology.organism_classification_rank.species ,Soil Science ,Plant community ,Development ,Arid ,Shrub ,Term (time) ,Tree (data structure) ,food ,Herb ,Environmental Chemistry ,Environmental science ,China ,General Environmental Science - Published
- 2020
31. Implementation of optical module performance prediction and maintenance on data-driven
- Author
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Dongmei Liu, Yongjun Yang, Zhifei Tang, and Zheng He
- Published
- 2022
32. Design of large off-axis aberration correction system for liquid mirror telescope based on MFDM and concave mirror
- Author
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Yongjun Yang, Dongjie Fu, Shuo Guo, Haichun Ding, and Zhizheng Wu
- Published
- 2022
33. Acute exposure to gold nanoparticles aggravates lipopolysaccharide-induced liver injury by amplifying apoptosis via ROS-mediated macrophage-hepatocyte crosstalk
- Author
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Yongjun Yang, Shijun Fan, Qian Chen, Yongling Lu, Yuanfeng Zhu, Xiaoli Chen, Lin Xia, Qianying Huang, Jiang Zheng, and Xin Liu
- Subjects
Lipopolysaccharides ,Male ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Metal Nanoparticles ,Bioengineering ,Lipopolysaccharide ,Apoptosis ,Cell Communication ,AuNPs ,Applied Microbiology and Biotechnology ,Mice ,Medical technology ,Acute liver injury ,Toxicity Tests, Acute ,Animals ,Humans ,R855-855.5 ,Research ,Macrophages ,Mice, Inbred C57BL ,HEK293 Cells ,Liver ,Chemical and Drug Induced Liver Injury, Chronic ,Hepatocytes ,Molecular Medicine ,Gold ,Reactive Oxygen Species ,TP248.13-248.65 ,Biotechnology - Abstract
Background Gold nanoparticles (AuNPs) are increasingly utilized in industrial and biomedical fields, thereby demanding a more comprehensive knowledge about their safety. Current toxicological studies mainly focus on the unfavorable biological impact governed by the physicochemical properties of AuNPs, yet the consequences of their interplay with other bioactive compounds in biological systems are poorly understood. Results In this study, AuNPs with a size of 10 nm, the most favorable size for interaction with host cells, were given alone or in combination with bacterial lipopolysaccharide (LPS) in mice or cultured hepatic cells. The results demonstrated that co exposure to AuNPs and LPS exacerbated fatal acute liver injury (ALI) in mice, although AuNPs are apparently non-toxic when administered alone. AuNPs do not enhance systemic or hepatic inflammation but synergize with LPS to upregulate hepatic apoptosis by augmenting macrophage-hepatocyte crosstalk. Mechanistically, AuNPs and LPS coordinate to upregulate NADPH oxidase 2 (NOX2)-dependent reactive oxygen species (ROS) generation and activate the intrinsic apoptotic pathway in hepatic macrophages. Extracellular ROS generation from macrophages is then augmented, thereby inducing calcium-dependent ROS generation and promoting apoptosis in hepatocytes. Furthermore, AuNPs and LPS upregulate scavenger receptor A expression in macrophages and thus increase AuNP uptake to mediate further apoptosis induction. Conclusions This study reveals a profound impact of AuNPs in aggravating the hepatotoxic effect of LPS by amplifying ROS-dependent crosstalk in hepatic macrophages and hepatocytes. Graphical Abstract
- Published
- 2022
34. Comparative Effect of Salinity on Antioxidant Enzymes of Two Wheat Genotypes by Foliar Application of Salicylic Acid and Potassium
- Author
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Jawaher Alkahtani, Humayun Bashir, Mona S. Alwahibi, Kafeel Ahmed, Mudasra Munir, Muhammad Nadeem, Jing Ma, Farzana Shaheen, Allah Bakhsh Gulshan, Zafar Iqbal Khan, Yongjun Yang, Fu Chen, Sonaina Nazar, and Muhammad Ashraf
- Subjects
chemistry.chemical_classification ,Antioxidant ,Process equipment ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,medicine.medical_treatment ,Potassium ,General Engineering ,food and beverages ,chemistry.chemical_element ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Salinity ,chemistry.chemical_compound ,Enzyme ,chemistry ,Petrochemistry ,Materials Chemistry ,medicine ,Food science ,General Pharmacology, Toxicology and Pharmaceutics ,Salicylic acid - Abstract
The aim of this work was to examine the ameliorative effect of foliar application of salicylic acid and potassium on antioxidant enzymes activity in wheat under saline conditions. Two wheat genotypes WL-711 (salt tolerant) and Kohistan-97 (salt sensitive) were used with salicylic acid (SA) and potassium (K+) foliar spray which were applied at both vegetative and grain filling stage under saline conditions. Various enzymatic antioxidant activities include catalase (CAT), peroxidase (POD), superoxide dismutase (SOD) and ascorbate peroxidase (APX) was assesed. Result cleared that foliar spray of salicylic acid and potassium decreased the damaged effect of salinity in both wheat genotypes especially Kohistan-97 which was more salt sensitive. Overall, foliarly applied salicylic acid and potassium reduces the adverse effects of reactive oxygen species and antioxidant enzymes on cellular metabolism that was disturbed by salt stress.
- Published
- 2020
35. Evaluation of Cobalt Concentration in the Forages and Small Ruminant Blood Collected from Various Agroecological Regions
- Author
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Yongjun Yang, Mudasra Munir, Sonaina Nazar, Ifra Saleem Malik, Ijaz Rasool Noorka, Tasneem Ahmad, Asma Ashfaq, Shahzad Akhtar, Zafar Iqbal Khan, Kinza Wajid, Samra Siddique, Naunain Mehmood, Muhammad Nadeem, Saleh A. Al-Farraj, Humayun Bashir, Jing Ma, Fu Chen, and Kafeel Ahmad
- Subjects
Process equipment ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,chemistry.chemical_element ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,chemistry ,Petrochemistry ,Environmental chemistry ,Materials Chemistry ,Small ruminant ,Environmental science ,General Pharmacology, Toxicology and Pharmaceutics ,Agroecology ,Cobalt - Abstract
Like animals plants required nutrients for their growth and existence. Cobalt is also important element for plant and animal growth, however higher levels of Co might have toxic potential. The study was aimed to investigate Co level in samples of forages, soil, and blood plasma of sheep and goat in Bhakkar, Mianwali and Sargodha district. The results showed that district Mianwali excelled in level of Co as compared to Bhakkar and Sargodha. The factors such as bio-concentration factor and pollution load index explained the movement of cobalt along the soil-plant-animal continuum.
- Published
- 2020
36. Assessing Health Risk in Livestock through Quantification of Iron in Forages, Soil and Buffalo Blood from Sargodha, Pakistan
- Author
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Humayun Bashir, Ifra Saleem Malik, Muhammad Nadeem, Yongjun Yang, Fu Chen, Nimra Arshad, Mudasra Munir, Muhammad Fahad Ullah, Ilker Ugulu, Jing Ma, Kafeel Ahmad, and Zafar Iqbal Khan
- Subjects
Process equipment ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Biotechnology ,Petrochemistry ,Materials Chemistry ,Livestock ,General Pharmacology, Toxicology and Pharmaceutics ,Health risk ,business - Abstract
Air pollution is very important issue now-a-days. This has affected the components of environment to a great extent. Organisms like animals, plants and human beings are forced to live in such polluted environments. One of the pollution sources to the environment is vehicular traffic which has toxic effect on the roadside plants. In this study, roadside forages, soil and buffalo blood were studied to estimate the level of heavy metal pollution, iron in particular, in Sargodha from six chosen sites at perimeter of major roads. Collected samples were processed and digested for quantification of iron by atomic absorption spectrophotometer. Soil and buffalo samples from the site V showed high concentration of iron, whereas in forage, samples collected from site IV had greatest iron concentration. The bio concentration factor found for forage-soil was highest in the samples collected from site IV. On the other hand, bio-concentration factor for blood-forage and pollution load index was found highest in the samples collected from site V. Correlation for soil-forage and blood-forage was found negatively non-significant. The daily intake of metals for iron was found highest for site IV. The Health risk index was highest for the samples collected from site VI.
- Published
- 2020
37. Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer
- Author
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Yongjun Yang, Chao Liu, and Xiaofeng Yang
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,photoimmunotherapy ,medicine.medical_treatment ,precision medicine ,Photodynamic diagnosis ,Photodynamic therapy ,lcsh:RC254-282 ,Article ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Pharmacology (medical) ,diagnosis and treatment ,Bladder cancer ,business.industry ,Carcinoma in situ ,Photoimmunotherapy ,Precision medicine ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,endoscopic molecular imaging ,030104 developmental biology ,Urethra ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Molecular Medicine ,bladder cancer ,Radiology ,Molecular imaging ,business - Abstract
Due to the high recurrence and progression rate of non-muscle invasive bladder cancer after transurethral resection of bladder tumor, some new optical imaging technologies have arisen as auxiliary imaging modes for white light cystoscopy to improve the detection rate of small or occult tumor lesions, such as photodynamic diagnosis, narrow-band imaging, and molecular imaging. White light cystoscopy is inadequate and imperfect for bladder cancer detection, and thus residual tumors or coexisting flat malignant lesions, especially carcinoma in situ, would be ignored during conventional resection. The bladder, a hollow organ with high compliance, provides an ideal closed operation darkroom for endoscopic molecular imaging free from interference of external light sources. Also, intravesical instillation of a molecular fluorescent tracer is simple and convenient before surgery through the urethra. Molecular fluorescent tracer has high sensitivity and specificity to tumor cells, and its mediated molecular imaging allows small or occult tumor lesion detection while minimizing false-positive results. Meanwhile, endoscopic molecular imaging provides a real-time and dynamic image during surgery, which helps urologists to perform high-quality and complete tumor resection through accurate judgment of tumor boundaries and depth of invasion. Photoimmunotherapy is a novel molecular targeted therapeutic pattern of photodynamic therapy that kills malignant cells selectively and minimizes the cytotoxicity to normal tissues. The combination of endoscopic molecular imaging and photoimmunotherapy used in initial treatment may avoid the need of repeat transurethral resection in strictly selected patients and improve oncological outcomes such as recurrence-free survival and overall survival after operation., Graphical Abstract
- Published
- 2020
38. Assessing Zinc Amassing in Forages, Buffalo Blood and Topsoil Collected from Sargodha City, Pakistan
- Author
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Humayun Bashir, Zafar Iqbal Khan, Jing Ma, Muhammad Nadeem, Hafsa Memona, Mubeen Akhtar, Ilker Ugulu, Farzana Shaheen, Asma Ashfaq, Yongjun Yang, Kinza Wajid, Pervaiz Akhter, Naunain Mehmood, Sonaina Nazar, Tasneem Ahmad, Shehzad Akhtar, Ifra Saleem Malik, Ijaz Rasool Noorka, Mudasra Munir, Shehzadi Mahpara, Saif Ullah, Fu Chen, Nimra Arshad, Kafeel Ahmad, and Taswar Abbas
- Subjects
Topsoil ,Process equipment ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,chemistry.chemical_element ,General Chemistry ,General Medicine ,Zinc ,General Biochemistry, Genetics and Molecular Biology ,chemistry ,Petrochemistry ,Environmental chemistry ,Materials Chemistry ,General Pharmacology, Toxicology and Pharmaceutics - Abstract
The article is focused on estimation of Zinc in the roadside forages, and blood of buffaloes feeding on these forages. This study was carried out in Sargodha during December 2015 to January 2016 (winter) and May 2016 to June 2016 (summer). Five road sites (Mateela, Faisalabad roadside, Shaheenabad roadside, Bhalwal roadside and 50 chak) were selected from sampling of forages, soil and buffalo blood sample. Heavy metal analysis of all digested samples was done with atomic absorption spectrophotometer. Analysis of variance and correlation was done with two way ANOVA. This study regarding the accumulation of zinc in forages, soil and the buffalo blood would help the authorities to exactly determine the agents which are responsible for increasing pollution in the environment.
- Published
- 2020
39. Relationship Between Metal Load (Selenium, Arsenic, Molybdenum) of Soil, Plant and Serum of Buffaloes
- Author
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Alireza Bayat, Yongjun Yang, Mohammad Reza Kouhkan Nejam, Zafar Iqbal Khan, Muhammad Fahad Ullah, Fu Chen, Ijza Rasool Noorka, Kafeel Ahmad, Asia Fardous, Ifra Saleem Malik, Sumaira Gondal, Humayun Bashir, Jing Ma, Naunain Mehmood, Kinza Wajid, Tasneem Ahmad, and Mudasra Munir
- Subjects
inorganic chemicals ,Process equipment ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,chemistry.chemical_element ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Metal ,chemistry ,Petrochemistry ,Molybdenum ,visual_art ,Environmental chemistry ,Materials Chemistry ,visual_art.visual_art_medium ,General Pharmacology, Toxicology and Pharmaceutics ,Selenium ,Arsenic - Abstract
Presence of hazardous minerals in three major components (soil, forage and buffalo serum) was evaluated for determining extent of metal contamination in Sargodha, Pakistan. Ten soil and forage samples for each season were taken from ten randomly selected sites. 30 grazing buffaloes of �niliravi� breed (calves, non-lactating and lactating) were also sampled randomly from these sites for collection of serum. Heavy metal quantification via atomic absorption spectrophotometry was carried out for selenium, molybdenum and arsenic. Non-significant but positive correlation was found for selenium (Se) concentrations in soil, forage and serum and molybdenum (Mo) concentrations in soil and serum. Negative correlation (p]0.05) was obtained for Mo level between forage-serum and soil-forage which was indicative of molybdenum deficiency in the soil. The results suggested that the heavy metals remained below maximum permissible levels and were non-toxic for the ruminants of the study area.
- Published
- 2020
40. Assessment of Cadmium in Maize and Millet of Different District using Canal and Wastewater Irrigation
- Author
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Yunus Dogan, Muhammad Nadeem, Humayun Bashir, Ifra Saleem Malik, Zafar Iqbal Khan, Fu Chen, Asma Ashfaq, Kafeel Ahmad, Ilker Ugulu, Yongjun Yang, Kinza Wajid, Mudasra Munir, and Jing Ma
- Subjects
Irrigation ,Cadmium ,Process equipment ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,Environmental engineering ,chemistry.chemical_element ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Wastewater ,chemistry ,Petrochemistry ,Materials Chemistry ,General Pharmacology, Toxicology and Pharmaceutics - Abstract
The article is focused on concentration of cadmium in maize and millet collected in 2018-2019 from different district (Sargodha, Faisalabad, Sheikhupura, Lahore and Kasur) of Punjab under different irrigation sources Canal and wastewater. The values of Bioconcentration factor, Translocation factor, Pollution load index, Daily intake of metal, Health Risk Index and Enrichment factor were studied to evaluate the effect of heavy metal accumulation on grains quality and human health. Most of the metals observed in wastewater were present in high amount. Cd concentration increased considerably under wastewater irrigation in soil (1.06 mg/kg) and grains (1.05 mg/kg). Cd showed highest bioconcentration (3.82 mg/kg) in canal water. Wastewater irrigated soil exhibited the maximum Pollution Load Index (PLI) values as compared to control treatment. Under the influence of wastewater irrigation, Cd concentration increased considerably in soil and grains. The purpose of study is the labeling of Maize and Millets species of the area according to their toxicity/desirability for use as human food and fodder.
- Published
- 2020
41. Assessment of Trace Metal Contents of Indigenous and Improved Pastures and Their Implications for Livestock in Terms of Seasonal Variations
- Author
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Ifra Saleem Malik, Ijaz Rasool Noorka, Shahzadi Mahpara, Mudasra Munir, Asma Ashfaq, Kinza Wajid, Ilker Ugulu, Zafar Iqbal Khan, Muhammad Fiaz Qamar, Yongjun Yang, Humayun Bashir, Kafeel Ahmad, Tasneem Ahmad, Muhammad Nadeem, Madiha Kiran, and Mian Jahan Zaib Rasheed
- Subjects
Process equipment ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Indigenous ,Environmental protection ,Petrochemistry ,Materials Chemistry ,Trace metal ,Livestock ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
The research was aimed to determine seasonal effects on trace metals levels in soil, forages and blood plasma of animals. The mean cadmium, chromium and copper values in soil samples in different sampling seasons were ranged from 6.97 to 4.10, 0.060 to 0.72 and 3.54to 4.08 mg/kg, respectively, while, in forage samples were between 0.671-0.697, 1.57-2.22 and 6.75-7.06 mg/kg, respectively. Higher Cd, Cr and Cu concentrations were observed in blood plasma of young buffaloes during summer season, in dry buffaloes during spring season and in young buffaloes during autumn season, while lower Cd, Cr and Cu contents were noticed in blood plasma of lactating buffaloes in summer season. The highest bio-concentration factor value from soil to forage was determined for Cr while from forage to blood plasma of buffaloes was detected for Cd. The Cd, Cr and Cu correlation of soil with blood plasma were positive for all samples.
- Published
- 2020
42. Surgical treatment of children Graves’ disease with huge goiter—a case report and literature review
- Author
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Fan Chai, Yi-Ceng Sun, Fan Zhang, Xiang Cui, Yan Liang, Yongjun Yang, Hongbiao Mo, Supeng Yin, Zeyu Yang, Yao Li, and Cong Shao
- Subjects
endocrine system ,Pediatrics ,medicine.medical_specialty ,Goiter ,endocrine system diseases ,business.industry ,medicine.medical_treatment ,Graves' disease ,Thyroid ,Thyroidectomy ,Case Report ,030209 endocrinology & metabolism ,Disease ,medicine.disease ,eye diseases ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Surgery ,Complication ,Surgical treatment ,business - Abstract
Graves’ disease is the most common cause of hyperthyroidism in children. The surgery treatment for children Graves’ disease with huge goiter is high risk and controversial. A 14-year-old girl suffered Graves’ disease with huge goiter and failed to the antithyroid drug therapy for nearly 4 years was surgically treated with total thyroidectomy. The excised thyroid weighed 449.1 g and heavier than any excised children goiter reported so far. After operation, the patient’s symptoms of Graves’ disease were significantly improved without any complication, including normal basal metabolic rate, relieved exophthalmia and euthyroidism. So, a children Graves’ disease with huge goiter was cured by total thyroidectomy, suggesting that a total/near-total thyroidectomy is a good option for children Graves’ disease with huge goiter.
- Published
- 2020
43. Preliminary study on the application of en bloc resection combined with near-infrared molecular imaging technique in the diagnosis and treatment of bladder cancer
- Author
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Yongjun Yang, Chao Liu, Jiawei Li, and Xiaofeng Yang
- Subjects
Male ,Nephrology ,Surgical margin ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Cystectomy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Survival rate ,Aged ,Retrospective Studies ,Bladder cancer ,business.industry ,Bladder Perforation ,En bloc resection ,Middle Aged ,medicine.disease ,Molecular Imaging ,Treatment Outcome ,Diagnostic Techniques, Surgical ,Urinary Bladder Neoplasms ,030220 oncology & carcinogenesis ,Female ,Obturator nerve ,Molecular imaging ,business ,Nuclear medicine - Abstract
To evaluate the surgical safety of en bloc resection of bladder tumor (ERBT) and the effectiveness of ERBT combined with near-infrared (NIR) imaging technique in the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). From October 2017 to June 2018, 26 patients newly diagnosed with single NMIBC were included in this retrospectively trial. All patients received ERBT with monopolar current. After surgery, the fresh specimen was incubated with anti-CD47-Alexa Fluor 790, and then imaged under NIR imaging technique. Operative details, intraoperative and postoperative complications of ERBT regarded as safety outcomes, the mean fluorescence intensity (MFI) of tumor tissue and adjacent normal background tissue, and 12 months follow-up data were analyzed. Of 26 collected patients, obturator nerve reflex was occurred in six patients during tumor resection, and only one patient was observed with bladder perforation. In NIR gray image, the gray scale of MFI of tumor tissue were 132.31 ± 6.67 and the adjacent normal background tissue were 52.27 ± 12.09. The result showed a significantly higher MFI signals in tumor tissue compared to adjacent normal background tissue (P < 0.001). The recurrence-free survival rate at 12 month was 96.15%. ERBT with monopolar current is a safe and feasible technique to treat patients with NMIBC. A integrated bladder tumor tissue-bound anti-CD47-Alexa Fluor 790 was detected under NIR light, and the NIR image indicates that higher MFI signals in surgical margin is a predictive factor for residual tumor in patients with NMIBC after ERBT.
- Published
- 2020
44. Induction of SOCS Expression by EV71 Infection Promotes EV71 Replication
- Author
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Yongjun Yang, Wenying Gao, Wenyan Zhang, Xin Liu, Min Hou, and Zhaolong Li
- Subjects
0301 basic medicine ,Article Subject ,medicine.medical_treatment ,Suppressor of Cytokine Signaling Proteins ,Receptor, Interferon alpha-beta ,Biology ,Virus Replication ,General Biochemistry, Genetics and Molecular Biology ,Mice ,03 medical and health sciences ,Suppressor of Cytokine Signaling 1 Protein ,Immune system ,Immunity ,Interferon ,Enterovirus Infections ,medicine ,Animals ,RNA, Messenger ,SOCS3 ,Enterovirus ,Mice, Knockout ,Gene knockdown ,Innate immune system ,030102 biochemistry & molecular biology ,General Immunology and Microbiology ,Suppressor of cytokine signaling 1 ,NF-kappa B ,General Medicine ,Immunity, Innate ,Up-Regulation ,Cell biology ,Disease Models, Animal ,030104 developmental biology ,Cytokine ,Suppressor of Cytokine Signaling 3 Protein ,Interferon Type I ,Medicine ,Research Article ,medicine.drug - Abstract
Enterovirus 71 (EV71) is the causative pathogen of hand, foot, and mouth disease (HFMD). However, no effective antiviral therapy is currently available. Some viruses could escape the host’s innate immunity by upregulating suppressor of cytokine signaling (SOCS) proteins. Until now, whether EV71 evades the host immune system by regulating the expression of SOCS proteins remains unknown. In this study, we found that EV71 infection promoted SOCS expression at both mRNA and protein levels in vitro and in vivo. Consistently, the infectivity of EV71 was decreased significantly in the SOCS3 or SOCS1 knockdown cells, suggesting that SOCS1 and especially SOCS3 are crucial for EV71 infection. Further investigation showed that SOCS3 promoted virus infection by inhibiting interferon-induced STAT3 phosphorylation. SOCS1 and SOCS3 mRNA expressions were independent on virus-induced type I interferon expression but were blocked by the inhibitor of NF-κB. Therefore, EV71 infection stimulates the expression of SOCS proteins in an interferon-independent way and negatively regulates the JAK/STAT signaling pathway, thus escaping host immunity. All these results may add new information to the mechanism of EV71 in fighting against type I interferon responses.
- Published
- 2020
45. Transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer based on TNM system
- Author
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Yongjun Yang, Xiaofeng Yang, Chao Liu, and Dongwen Wang
- Subjects
Cancer Research ,medicine.medical_specialty ,Bladder cancer ,business.industry ,En bloc resection ,TNM system ,medicine.disease ,monopolar current ,transurethral resection of bladder tumor (TURBT) ,Surgery ,Oncology ,medicine ,Radiology, Nuclear Medicine and imaging ,Original Article ,business ,Non muscle invasive ,en bloc resection - Abstract
Background To evaluate the surgical safety and quality of transurethral en bloc resection with monopolar current for non-muscle invasive bladder cancer (NMIBC) based on the tumour, node, metastasis (TNM) classification system, and report the midterm oncological outcome. Methods From October 2015 to June 2017, en bloc resection of bladder tumor (ERBT) and transurethral resection of bladder tumor (TURBT) were performed in 96 and 87 patients clinically diagnosed with NMIBC in the prospective case-control trial, respectively. Operative details, intraoperative and postoperative complications regarded as safety outcomes were documented. The quality of ERBT was judged by the histopathological examination of tumor specimens from initial resection and second TURBT, random bladder biopsy and follow-up recurrence rate. Results Operative time, obturator nerve reflex, irrigation and catheterization time were similar in the two groups. Bladder perforation was occurred in 2 patients during ERBT and 9 patients during TURBT (2/96 vs. 9/87, P=0.019). Compared with TURBT group, the ratio of detrusor muscle (DM) identified in pathologic T1 tumor specimens was higher (P=0.024), but lower in pathologic Ta tumor specimens in ERBT group (P
- Published
- 2020
46. Spatial assessment of farmland soil pollution and its potential human health risks in China
- Author
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Fu Chen, Siyan Zeng, Gang-Jun Liu, Yongjun Yang, Shaoliang Zhang, and Jing Ma
- Subjects
Pollution ,China ,Farms ,Food Safety ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,media_common.quotation_subject ,010501 environmental sciences ,Risk Assessment ,01 natural sciences ,Soil management ,Environmental protection ,Environmental monitoring ,Humans ,Soil Pollutants ,Environmental Chemistry ,Waste Management and Disposal ,Ecosystem ,0105 earth and related environmental sciences ,media_common ,Health risk assessment ,business.industry ,Food safety ,Hazard ,Soil contamination ,Environmental science ,Environmental Pollution ,business ,Environmental Monitoring - Abstract
Soil pollution severely threatens agro-ecosystem stability. It is important to accurately understand the status of farmland pollution in order to protect national food safety and human health. However, information of the combined pollution level of Chinese farmland soil and associated human health risk at the national scale is relatively lacking. In this study, 5597 samples from 1781 farmland soil sites were obtained from 553 reports and combined into pollution databases of heavy metals, organochlorines, and polycyclic aromatic hydrocarbons. Based on the data obtained, this paper demonstrated the current pollution status of farmland soil, and assessed the subsequent human health risk. Results showed that the combined pollution ratio of Chinese farmland soil was 22.10%, with 1.23% of severe pollution level. Moreover, the total non-carcinogenic hazard quotients of farmland soil pollution were within the safety threshold for adults, but there was a slight non-carcinogenic risk for children. For adults, the ratio of total farmland area to total carcinogenic risk quotients above the safety threshold of 1 × 10−5 was only 1.02%, but for children, the ratio was as high as 20.75%. On the other side, food crop and vegetable plantations were the priority control farmland soil compared to other types. Meanwhile, Yunnan, Hunan, Anhui, Henan, and Liaoning were selected as the priority control provinces due to their severe pollutions and high human health risks. This study has provided a comprehensive pollution and health risk assessment. Furthermore, the spatial distribution might provide as the scientific support for accelerating the mapping of soil pollution in China, as well as developing the policy for the contaminated farmland soil management.
- Published
- 2019
47. Vegetation patterns on a landslide after five years of natural restoration in the Loess Plateau mining area in China
- Author
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Run Liu, Huping Hou, Jiaxin Mi, Fuyao Chen, Shaoliang Zhang, Zhang Liming, and Yongjun Yang
- Subjects
Hydrology ,Environmental Engineering ,Soil seed bank ,business.industry ,Coal mining ,Landslide ,04 agricultural and veterinary sciences ,Vegetation ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,01 natural sciences ,Natural (archaeology) ,Germination ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Revegetation ,business ,Restoration ecology ,Geology ,0105 earth and related environmental sciences ,Nature and Landscape Conservation - Abstract
Landslides represent the most intense type of geological disaster in the gully region of the Loess Plateau and have caused great damage to surface vegetation. Natural restoration is considered as an effective method for revegetation, however, vegetation patterns on landslides after natural restoration and its related factors remain poorly understood. The present study investigated vegetation patterns on a landslide after 5 years of natural restoration, which located in Hezhai coal mining area, Shanxi Province, China, to understand the natural restoration of vegetation after landslides. The species composition on the bottom, middle and top of the landslide, as well as the species importance value, plant diversity and similarity were ascertained and compared with the that on undisturbed site. Furthermore, the soil seed bank in another landslide which just experienced 0.5-year natural restoration was also investigated, and a seed bank germination experiment was performed based on the collected seed samples from the landslide to test their vitalities. Results showed that 20 species of vegetation were found on all three parts of the landslide, which all belonged to herbaceous plants and shrubs. Eleusine indica was dominant in both the bottom and middle of the landslide, while the top was dominated by Potentilla sischanensis. From the bottom to the top of landslide, the Margalef Index was 3.26, 3.91, and 2.17 respectively; the Shannon–Wiener Index was 2.56, 2.60, and 2.13 respectively; the Pielou Index was 0.55, 0.56, and 0.46, respectively. Species similarity revealed a close relationship between species compositions on restored landslide and undisturbed area. A total of 13 species of seeds were found in the soil seed bank, which were also similar to the aboveground plants on disturbed site and the landslide after 5-year natural restoration, and the seed was also proved vital in the seed bank experiment. These results indicated that vegetation on landslides could recovery naturally, and natural restoration was more effective on the bottom and middle of the landslide, which revealed that changes in topography could affect revegetation. The seed bank in the soil was considered as a main factor affecting natural restoration. This research provides useful insight into the natural restoration of vegetation after landslides, and provides a reference for the selection of ecological restoration strategies.
- Published
- 2019
48. High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease
- Author
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Zilei Duan, Li Fu, Yan Li, Gang Guo, Yun Shi, Jinyong Zhang, Yanjing Zhang, Kaiyun Liu, Hao Zeng, Yongjun Yang, Ren Lai, Quanming Zou, Xiangcheng Sun, Shulei Pan, and Ning Wang
- Subjects
Cancer Research ,2019-20 coronavirus outbreak ,Letter ,Pyrrolidines ,Proline ,Coronavirus disease 2019 (COVID-19) ,Protein Conformation ,QH301-705.5 ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,High-throughput screening ,Pneumonia, Viral ,Viral Nonstructural Proteins ,Virus Replication ,Antiviral Agents ,Target validation ,Betacoronavirus ,Inhibitory Concentration 50 ,Chlorocebus aethiops ,Drug Discovery ,High-Throughput Screening Assays ,Genetics ,medicine ,Animals ,Humans ,Biology (General) ,Pandemics ,Vero Cells ,Coronavirus 3C Proteases ,Glycoproteins ,Protease ,SARS-CoV-2 ,business.industry ,COVID-19 ,Virology ,Cysteine Endopeptidases ,Kinetics ,Drug screening ,A549 Cells ,Peptide Hydrolases ,Medicine ,Caco-2 Cells ,Sulfonic Acids ,Coronavirus Infections ,business - Abstract
A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic. The disease caused by SARS-CoV-2 virus is called COVID-19, which is highly contagious and has an overall mortality rate of 6.35% as of May 26, 2020. There is no vaccine or antiviral available for SARS-CoV-2. In this study, we report our discovery of inhibitors targeting the SARS-CoV-2 main protease (M
- Published
- 2021
49. Progressive Deep Learning Framework for Recognizing 3D Orientations and Object Class Based on Point Cloud Representation
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Yongjun Yang and Sukhan Lee
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Network complexity ,Generalization ,Computer science ,Association (object-oriented programming) ,3D object ,TP1-1185 ,Biochemistry ,Article ,Analytical Chemistry ,Deep Learning ,progressive learning ,Electrical and Electronic Engineering ,Representation (mathematics) ,Instrumentation ,Orientation (computer vision) ,business.industry ,Chemical technology ,Deep learning ,Pattern recognition ,association network ,Object (computer science) ,Atomic and Molecular Physics, and Optics ,3D point cloud ,Artificial intelligence ,business ,Transfer of learning ,orientation representation - Abstract
Deep learning approaches to estimating full 3D orientations of objects, in addition to object classes, are limited in their accuracies, due to the difficulty in learning the continuous nature of three-axis orientation variations by regression or classification with sufficient generalization. This paper presents a novel progressive deep learning framework, herein referred to as 3D POCO Net, that offers high accuracy in estimating orientations about three rotational axes yet with efficiency in network complexity. The proposed 3D POCO Net is configured, using four PointNet-based networks for independently representing the object class and three individual axes of rotations. The four independent networks are linked by in-between association subnetworks that are trained to progressively map the global features learned by individual networks one after another for fine-tuning the independent networks. In 3D POCO Net, high accuracy is achieved by combining a high precision classification based on a large number of orientation classes with a regression based on a weighted sum of classification outputs, while high efficiency is maintained by a progressive framework by which a large number of orientation classes are grouped into independent networks linked by association subnetworks. We implemented 3D POCO Net for full three-axis orientation variations and trained it with about 146 million orientation variations augmented from the ModelNet10 dataset. The testing results show that we can achieve an orientation regression error of about 2.5° with about 90% accuracy in object classification for general three-axis orientation estimation and object classification. Furthermore, we demonstrate that a pre-trained 3D POCO Net can serve as an orientation representation platform based on which orientations as well as object classes of partial point clouds from occluded objects are learned in the form of transfer learning.
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- 2021
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50. Response of Soil Microbial Community to Vegetation Reconstruction Modes in Mining Areas of the Loess Plateau, China
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Fu Chen, Shaoliang Zhang, Jiao Zhao, Haochen Yu, Yongjun Yang, and Jing Ma
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Microbiology (medical) ,geography ,geography.geographical_feature_category ,Ecology ,Soil organic matter ,ecological restoration ,vegetation reconstruction ,Vegetation ,complex mixtures ,Microbiology ,Grassland ,QR1-502 ,soil bacterial ,Microbial ecology ,Microbial population biology ,Soil pH ,Environmental science ,Ecosystem ,damaged mine ,Restoration ecology ,soil fungal ,Original Research - Abstract
Vegetation reconstruction and restoration is vital to the health of the mine land ecosystem. Different vegetations might change microbial community structure and function of soil, mediating the biogeochemical cycle and nutrition supply to the soil. To clarify the response of soil microbes to different vegetation reconstruction modes in the mining areas of the Loess Plateau, China, soil microbial community structures and functions were determined by the MiSeq high-throughput sequencing along with PICRUSt2 and FUNGuild tools. The fungal community richness was observed to be the highest in grassland soil and positively correlated with soil organic matter, total nitrogen, and nitrate-nitrogen. The bacterial and fungal community structures were similar in grassland and brushland areas, but were significantly differentiated in the coniferous and broadleaf forest, and the leading factors were soil pH and nitrate-nitrogen. Actinobacteriota, Proteobacteria, and Acidobacteriota were the dominant bacterial phyla under different vegetation reconstruction modes. The dominant phyla of fungi were Ascomycota, Basidiomycota, and Mortierellomycota. Different vegetation reconstruction modes did not affect the bacterial functional communities but shaped different functional groups of fungi. The grassland soil was dominated by saprotrophic fungi, while symbiotrophic fungi dominated the coniferous and broadleaf forests. The results suggested that shifts in vegetation reconstruction modes may alter the mining soil bacterial and fungal community structures and function. These findings improve the understanding of microbial ecology in the reclaimed mine soil and provide a reference for the ecological restoration of fragile mining ecosystems.
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- 2021
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