37 results on '"Wibhu Kutanan"'
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2. Genetic Structure and Forensic Utility of 23 Autosomal STRs of the Ethnic Lao Groups From Laos and Thailand
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Khaing Zin Than, Kanha Muisuk, Wipada Woravatin, Chatmongkon Suwannapoom, Metawee Srikummool, Suparat Srithawong, Sengvilay Lorphengsy, and Wibhu Kutanan
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Genetics ,Molecular Medicine ,Genetics (clinical) - Abstract
The Lao Isan and Laotian are the major groups in the area of present-day northeastern Thailand and Laos, respectively. Several previous genetic and forensic studies indicated an admixed genetic structure of Lao Isan with the local Austroasiatic speaking groups, e.g. Khmer, whereas there is a paucity of reporting Laotian’s forensic short tandem repeats (STRs). Here, we newly generated 451 genotypes of seven Lao Isan and three Laotian populations (two Lao Lum and one Lao Thoeng) using 23 autosomal STRs embedded in VerifilerTM plus PCR Amplification kit. We reported allelic frequency and forensic parameters in different dataset: combined ethnic Lao groups, combined Lao Isan populations and combined Laotians. Overall, the forensic parameter results indicate that this set of STRs is suitable for forensic investigation. The anthropological results revealed the genetic homogeneity of Tai-Kadai speaking Lao groups from Thailand and Laos, consistent with previous studies, while the Austroasiatic speaking groups from southern Laos showed genetic relatedness to both Lao Isan and Khmer. In sum, STRs allelic frequency results can provide the genetic backgrounds of populations which is useful for anthropological research and also strengthens the regional forensic database in both countries.
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- 2022
3. Reconstructing the Human Genetic History of Mainland Southeast Asia: Insights from Genome-Wide Data from Thailand and Laos
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Sukrit Sangkhano, Rasmi Shoocongdej, Dang Liu, Sukhum Ruangchai, Jatupol Kampuansai, Metawee Srikummool, Wibhu Kutanan, Leonardo Arias, Pittayawat Pittayaporn, Suparat Srithawong, and Mark Stoneking
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South asia ,cultural diffusion ,Population ,Biology ,AcademicSubjects/SCI01180 ,Genome ,Polymorphism, Single Nucleotide ,Southeast asia ,genome-wide ,03 medical and health sciences ,Mainland Southeast Asia ,Genetic drift ,Asian People ,Genetics ,Humans ,education ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Discoveries ,Alleles ,030304 developmental biology ,Language ,Whole genome sequencing ,0303 health sciences ,education.field_of_study ,population interaction ,Genome, Human ,030305 genetics & heredity ,AcademicSubjects/SCI01130 ,Thailand ,Geography ,Evolutionary biology ,South Asian admixture ,Laos ,Genetic structure ,Mainland - Abstract
Thailand and Laos, located in the center of Mainland Southeast Asia (MSEA), harbor diverse ethnolinguistic groups encompassing all five language families of MSEA: Tai-Kadai (TK), Austroasiatic (AA), Sino-Tibetan (ST), Hmong-Mien (HM), and Austronesian (AN). Previous genetic studies of Thai/Lao populations have focused almost exclusively on uniparental markers and there is a paucity of genome-wide studies. We therefore generated genome-wide SNP data for 33 ethnolinguistic groups, belonging to the five MSEA language families from Thailand and Laos, and analyzed these together with data from modern Asian populations and SEA ancient samples. Overall, we find genetic structure according to language family, albeit with heterogeneity in the AA-, HM-, and ST-speaking groups, and in the hill tribes, that reflects both population interactions and genetic drift. For the TK speaking groups, we find localized genetic structure that is driven by different levels of interaction with other groups in the same geographic region. Several Thai groups exhibit admixture from South Asia, which we date to ∼600–1000 years ago, corresponding to a time of intensive international trade networks that had a major cultural impact on Thailand. An AN group from Southern Thailand shows both South Asian admixture as well as overall affinities with AA-speaking groups in the region, suggesting an impact of cultural diffusion. Overall, we provide the first detailed insights into the genetic profiles of Thai/Lao ethnolinguistic groups, which should be helpful for reconstructing human genetic history in MSEA and selecting populations for participation in ongoing whole genome sequence and biomedical studies.
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- 2021
4. Forensic and genetic characterizations of diverse southern Thai populations based on 15 autosomal STRs
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Metawee Srikummool, Suparat Srithawong, Kanha Muisuk, Sukrit Sangkhano, Chatmongkon Suwannapoom, Jatupol Kampuansai, and Wibhu Kutanan
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Forensic Genetics ,Male ,Multidisciplinary ,Science ,Genetic Drift ,Datasets as Topic ,Thailand ,Article ,Genetics, Population ,Gene Frequency ,Population Groups ,parasitic diseases ,Databases, Genetic ,Medicine ,Humans ,Genotyping and haplotyping ,Female ,Genetic variation ,Structural variation ,PCR-based techniques ,Alleles ,Microsatellite Repeats - Abstract
Southern Thailand is home to various populations; the Moklen, Moken and Urak Lawoi’ sea nomads and Maniq negrito are the minority, while the southern Thai groups (Buddhist and Muslim) are the majority. Although previous studies have generated forensic STR dataset for major groups, such data of the southern Thai minority have not been included; here we generated a regional forensic database of southern Thailand. We newly genotyped common 15 autosomal STRs in 184 unrelated southern Thais, including all minorities and majorities. When combined with previously published data of major southern Thais, this provides a total of 334 southern Thai samples. The forensic parameter results show appropriate values for personal identification and paternity testing; the probability of excluding paternity is 0.99999622, and the combined discrimination power is 0.999999999999999. Probably driven by genetic drift and/or isolation with small census size, we found genetic distinction of the Maniq and sea nomads from the major groups, which were closer to the Malay and central Thais than the other Thai groups. The allelic frequency results can strength the regional forensic database in southern Thailand and also provide useful information for anthropological perspective.
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- 2022
5. Unveiling the Genetic History of the Maniq, a Primary Hunter-Gatherer Society
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Tobias Göllner, Maximilian Larena, Wibhu Kutanan, Helmut Lukas, Martin Fieder, and Helmut Schaschl
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Evolutionary Biology ,Negritos ,population genetics ,Thailand ,Polymorphism, Single Nucleotide ,Southeast Asia ,genetic ancestry ,Evolutionsbiologi ,Genetics, Population ,Asian People ,Semang ,Genetics ,Animals ,Humans ,Ecology, Evolution, Behavior and Systematics ,Asia, Southeastern ,Neanderthals - Abstract
The Maniq of southern Thailand is one of the last remaining practicing hunter-gatherer communities in the world. However, our knowledge on their genetic origins and demographic history is still largely limited. We present here the genotype data covering ∼2.3 million single nucleotide polymorphisms of 11 unrelated Maniq individuals. Our analyses reveal the Maniq to be closely related to the Semang populations of Malaysia (Malay Negritos), who altogether carry an Andamanese-related ancestry linked to the ancient Hòabìnhian hunter-gatherers of Mainland Southeast Asia (MSEA). Moreover, the Maniq possess ∼35% East Asian-related ancestry, likely brought about by recent admixture with surrounding agriculturist communities in the region. In addition, the Maniq exhibit one of the highest levels of genetic differentiation found among living human populations, indicative of their small population size and historical practice of endogamy. Similar to other hunter-gatherer populations of MSEA, we also find the Maniq to possess low levels of Neanderthal ancestry and undetectable levels of Denisovan ancestry. Altogether, we reveal the Maniq to be a Semang group that experienced intense genetic drift and exhibits signs of ancient Hòabìnhian ancestry.
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- 2022
6. Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand
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Metawee Srikummool, Aornpriya Mawan, Suparat Srithawong, Kanha Muisuk, Sukhum Ruangchai, Angkhana Inta, Rasmi Shoocongdej, Jatupol Kampuansai, Wibhu Kutanan, and Nonglak Prakhun
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Male ,0301 basic medicine ,Genotype ,lcsh:QH426-470 ,Population ,Ethnic group ,Article ,microsatellites ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Genetic variation ,hill tribes ,Ethnicity ,Genetics ,Tribe ,Humans ,030216 legal & forensic medicine ,education ,Genetics (clinical) ,Hmong-Mien ,forensic database ,education.field_of_study ,Genetic heterogeneity ,Thailand ,Genetic divergence ,lcsh:Genetics ,030104 developmental biology ,Geography ,Genetic structure ,Microsatellite ,Ethnology ,Female ,Microsatellite Repeats - Abstract
The hill tribes of northern Thailand comprise nine officially recognized groups: the Austroasiatic-speaking (AA) Khmu, Htin and Lawa, the Hmong-Mien-speaking (HM) IuMien and Hmong, and the Sino-Tibetan-speaking (ST) Akha, Karen, Lahu and Lisu. Except the Lawa, the rest of the hill tribes migrated into their present habitats only very recently. The Thai hill tribes were of much interest to research groups focusing on study of cultural and genetic variation because of their unique languages and cultures. So far, there have been several genetic studies of the Thai hill tribes. However, complete forensic microsatellite database of the Thai hill tribes is still lacking. To construct such database, we newly generated 654 genotypes of 15 microsatellites commonly used in forensic investigation that belong to all the nine hill tribes and also non-hill tribe highlanders from northern Thailand. We also combined 329 genotypes from previous studies of northern Thai populations bringing to a total of 983 genotypes, which were then subjected to genetic structure and population relationships analyses. Our overall results indicated homogenous genetic structure within the HM- and Tai-Kadai (TK)-speaking groups, large genetic divergence of the HM-speaking Hmong but not IuMien from the other Thai groups, and genetic heterogeneity within the ST- and AA-speaking groups, reflecting different population interactions and admixtures. In addition to establishing genetic relationships within and among these populations, our finding, which provides a more complete picture of the forensic microsatellite database of the multiple Thai highland dwellers, would not only serve to expand and strengthen forensic investigation in Thailand, but would also benefit its neighboring countries of Laos and Myanmar, from which many of the Thai hill tribes originated and where large populations of these ethnic groups still reside.
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- 2021
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7. Indian genetic heritage in Southeast Asian populations
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Pavel Flegontov, Yüncü E, Olga Flegontova, Angkhana Inta, Altınışık Ne, Piya Changmai, Jaisamut K, David Reich, Wibhu Kutanan, Horolma Pamjav, Boonthai W, and Jatupol Kampuansai
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education.field_of_study ,biology ,media_common.quotation_subject ,Population ,Ethnic group ,Genetic admixture ,biology.organism_classification ,Southeast asian ,Geography ,Iron Age ,Anatomically modern human ,Ethnology ,Mainland ,education ,Diversity (politics) ,media_common - Abstract
The great ethnolinguistic diversity found today in mainland Southeast Asia (MSEA) reflects multiple migration waves of people in the past. Deeply divergent East Eurasian hunter-gatherers were the first anatomically modern human population known to migrate to the region. Agriculturalists from South China migrated to the region and admixed with the local hunter-gatherers during the Neolithic period. During the Bronze and Iron Ages, the genetic makeup of people in MSEA changed again, indicating an additional influx of populations from South China. Maritime trading between MSEA and India was established at the latest 300 BCE, and the formation of early states in Southeast Asia during the first millennium CE was strongly influenced by Indian culture, and this cultural influence is still prominent today. Several ancient Indian-influenced states were located in present-day Thailand, and various populations in the country are likely to be descendants of people from those states. To systematically explore Indian genetic heritage in MSEA, we generated genome-wide SNP data (the HumanOrigins array) for 119 present-day individuals belonging to 10 ethnic groups from Thailand and co-analyzed them with published data from MSEA using the PCA, ADMIXTURE,f3-statistics, qpAdm, and qpGraph methods. We found South Asian low-level admixture in various MSEA populations which are probably descendants of people from the ancient Indian-influenced states, but failed to find a South Asian genetic component in present-day hunter-gatherer groups and relatively isolated groups from highlands in Northern Thailand. Our results also support close genetic affinity between Kra-Dai-speaking (also known as Tai-Kadai) and Austronesian-speaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.Author SummaryMainland Southeast Asia is a region with great ethnolinguistic diversity and complex population history. We studied genetic population history of present-day mainland Southeast Asian populations using genome-wide SNP data (the HumanOrigins array). We generated new data for 10 present-day ethnic groups from Thailand, which we further combined with published data from mainland and island Southeast Asians and worldwide populations. We revealed South Asian genetic admixture in various mainland Southeast Asian ethnic groups which are highly influenced by Indian culture, but failed to find it in groups who remained culturally isolated until recently. Our finding suggests that a massive migration of Indian people in the past was responsible for the spread of Indian culture in mainland Southeast Asia. We also found support for a close genetic affinity between Kra-Dai- and Austronesianspeaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.
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- 2021
8. Indian genetic heritage in Southeast Asian populations
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Piya Changmai, Kitipong Jaisamut, Jatupol Kampuansai, Wibhu Kutanan, N. Ezgi Altınışık, Olga Flegontova, Angkhana Inta, Eren Yüncü, Worrawit Boonthai, Horolma Pamjav, David Reich, and Pavel Flegontov
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Cancer Research ,Genetic Variation ,India ,Thailand ,Polymorphism, Single Nucleotide ,Genetics, Population ,Asian People ,Haplotypes ,Ethnicity ,Genetics ,Humans ,Molecular Biology ,Asia, Southeastern ,Genetics (clinical) ,Ecology, Evolution, Behavior and Systematics ,Language - Abstract
The great ethnolinguistic diversity found today in mainland Southeast Asia (MSEA) reflects multiple migration waves of people in the past. Maritime trading between MSEA and India was established at the latest 300 BCE, and the formation of early states in Southeast Asia during the first millennium CE was strongly influenced by Indian culture, a cultural influence that is still prominent today. Several ancient Indian-influenced states were located in present-day Thailand, and various populations in the country are likely to be descendants of people from those states. To systematically explore Indian genetic heritage in MSEA populations, we generated genome-wide SNP data (using the Affymetrix Human Origins array) for 119 present-day individuals belonging to 10 ethnic groups from Thailand and co-analyzed them with published data using PCA, ADMIXTURE, and methods relying on f-statistics and on autosomal haplotypes. We found low levels of South Asian admixture in various MSEA populations for whom there is evidence of historical connections with the ancient Indian-influenced states but failed to find this genetic component in present-day hunter-gatherer groups and relatively isolated groups from the highlands of Northern Thailand. The results suggest that migration of Indian populations to MSEA may have been responsible for the spread of Indian culture in the region. Our results also support close genetic affinity between Kra-Dai-speaking (also known as Tai-Kadai) and Austronesian-speaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.
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- 2022
9. Unique Genetic Structure of Y-chromosomal Lineage of the Moken from the Andaman Sea of Thailand
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Metawee Srikummool, Kanha Muisuk, Wibhu Kutanan, Jatupol Kampuansai, and Tanapon Seetaraso
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Lineage (genetic) ,Evolutionary biology ,Genetic structure ,Medicine (miscellaneous) ,Dentistry (miscellaneous) ,Environmental Science (miscellaneous) ,Biology ,Agricultural and Biological Sciences (miscellaneous) ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Health Professions (miscellaneous) - Published
- 2020
10. Close genetic relationship between central Thai and Mon people in Thailand revealed by autosomal microsatellites
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Pittayawat Pittayaporn, Suparat Srithawong, Kanha Muisuk, Metawee Srikummool, Sukhum Ruangchai, Jatupol Kampuansai, Wibhu Kutanan, and Dang Liu
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biology ,Genotype ,Genetic relationship ,Thais ,biology.organism_classification ,Thailand ,Pathology and Forensic Medicine ,Forensic science ,Geography ,Genetics, Population ,Genetic similarity ,Asian People ,Gene Frequency ,parasitic diseases ,Ethnicity ,Microsatellite ,Humans ,Multidimensional Scaling Analysis ,Allele frequency ,Demography - Abstract
Central Thailand is home to diverse populations with the central Thai constituting the major group, while the Mon, who migrated from southern Myanmar, are sparsely distributed within the region. A total of 338 individuals of eight central Thai (246 samples) and three Mon populations (92 samples) were newly genotyped. When combined with our previously published Mon data, this provides a total of 139 Mon samples. We found genetic similarity between the central Thai and Mon and weak sub-structuring among Thais from central, northern, and northeastern Thailand. The forensic parameter results show high discrimination values which are appropriate for forensic personal identification and paternity testing in both the central Thai and Mon; the probabilities of excluding paternity are 0.999999112 and 0.999999031, respectively, and the combined discrimination power is 0.9999999999999999999999 in both groups. This regional allelic frequency on forensic microsatellites may serve as a useful reference for further forensic investigations in both Thailand and Myanmar.
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- 2020
11. New insights from Thailand into the maternal genetic history of Mainland Southeast Asia
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Alexander Hübner, Roland Schröder, Silvia Ghirotto, Metawee Srikummool, Andrea Brunelli, Enrico Macholdt, Daoroong Kangwanpong, Leonardo Arias Alvis, Sukhum Ruangchai, Wibhu Kutanan, Pittayawat Pittayaporn, Jatupol Kampuansai, and Mark Stoneking
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0106 biological sciences ,0301 basic medicine ,China ,Genetics ,Genetics (clinical) ,Population ,Socio-culturale ,Thais ,DNA, Mitochondrial ,010603 evolutionary biology ,01 natural sciences ,Haplogroup ,Southeast asia ,Gene flow ,03 medical and health sciences ,Asian People ,Demic diffusion ,Ethnicity ,Humans ,education ,Asia, Southeastern ,History, Ancient ,Language ,education.field_of_study ,Chromosomes, Human, Y ,biology ,Haplotype ,Genetic Variation ,Thailand ,biology.organism_classification ,Genetics, Population ,030104 developmental biology ,Geography ,Haplotypes ,Southern china ,Ethnology ,Mainland ,Microsatellite Repeats - Abstract
Tai-Kadai (TK) is one of the major language families in Mainland Southeast Asia (MSEA), with a concentration in the area of Thailand and Laos. Our previous study of 1,234 mtDNA genome sequences supported a demic diffusion scenario in the spread of TK languages from southern China to Laos as well as northern and northeastern Thailand. Here we add an additional 560 mtDNA sequences from 22 groups, with a focus on the TK-speaking central Thai people and the Sino-Tibetan speaking Karen. We find extensive diversity, including 62 haplogroups not reported previously from this region. Demic diffusion is still a preferable scenario for central Thais, emphasizing the extension and expansion of TK people through MSEA, although there is also some support for an admixture model. We also tested competing models concerning the genetic relationships of groups from the major MSEA languages, and found support for an ancestral relationship of TK and Austronesian-speaking groups.
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- 2018
12. Allelic frequencies of fifteen autosomal STRs in the northeastern Thai people
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Suparat Srithawong, Wibhu Kutanan, and Kanha Muisuk
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Male ,Genotype ,Genetic relationship ,Southeast asian ,Thais ,01 natural sciences ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Gene Frequency ,parasitic diseases ,Ethnicity ,Humans ,030216 legal & forensic medicine ,Allele ,Allele frequency ,biology ,Phylogenetic tree ,010401 analytical chemistry ,Southern chinese ,Thailand ,biology.organism_classification ,DNA Fingerprinting ,0104 chemical sciences ,Forensic science ,Genetics, Population ,Evolutionary biology ,Female ,geographic locations ,Microsatellite Repeats - Abstract
We genotyped 15 autosomal STRs loci in 1780 unrelated northeastern Thai individuals. Allele frequencies were computed and all of the loci reached Hardy-Weinberg equilibrium. The forensic parameter results showed high discrimination values which are suitable for forensic personal identification and paternity testing; the combined discrimination power and probability of excluding paternity were 0.9999999999999999999999 and 0.999998449, respectively. Genetic relatedness of northeastern Thais with comparable Thai and Asian populations using phylogenetic analysis revealed close genetic relationship between Mainland Southeast Asian populations and southern Chinese populations.
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- 2019
13. Genetic structure of the ethnic Lao groups from mainland Southeast Asia revealed by forensic microsatellites
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Kanha Muisuk, Kamnikone Sriprasert, Suparat Srithawong, Wibhu Kutanan, Saksuriya Triyarach, Narongdet Mahasirikul, and Metawee Srikummool
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0303 health sciences ,Genetic diversity ,Models, Genetic ,Genetic genealogy ,030305 genetics & heredity ,Ethnic group ,Genetic admixture ,Genetic relationship ,Thailand ,03 medical and health sciences ,Geography ,Genetics, Population ,Gene Frequency ,Evolutionary biology ,Laos ,Genetic structure ,Genetics ,Ethnicity ,Microsatellite ,Humans ,Mainland ,Genetics (clinical) ,030304 developmental biology ,Microsatellite Repeats - Abstract
Purpose Laotians and Lao Isan are widely spread Lao groups who live in Laos and northeastern Thailand, respectively. We explored the genetic structure between them and other ethnic groups from Thailand to clarify historical patterns of admixture between Tai-Kadai and Austroasiatic speakers, and to expand the forensic reference database for the region. Subjects and methods We combined new genetic data for 554 individuals from 12 populations, typed for 15 autosomal short tandem repeats, with available data from 14 populations from Thailand, for a total of 1,153 raw genotypes belonging to 26 populations. We calculated forensic parameters and performed various analyses on genetic diversity, genetic structure, genetic admixture, and genetic relationships among the studied populations. Results Forensic estimators suggest a good power of discrimination with the combined power of exclusion ranging from 0.993628 to 0.999991 and a combined power of discrimination value greater than 0.99999999. Generally, the two Laotian groups were genetically similar, but the central Laotians from Vientiane have a closer genetic relationship to the Lao Isan than the northern Laotians from Luang Prabang. The Lao genetic ancestry forms the majority of the Lao Isan genetic makeup, while Austroasiatic ancestry is present at ∼10%-50%. Conclusions Lao Isan populations show signs of Lao ancestry and admixture with local Austroasiatic ancestry, which reflect historical migrations from Laos to Thailand. Lao speakers are genetically more homogeneous than Austroasiatic speakers, suggesting differential historical processes.
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- 2019
14. Partial Sequence Analysis of Cytochrome b Gene by FINS Technique Reveals Fraud Sambar Meat in Wild Food Restaurant
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Chavin Chaisongkram, Thanat Vorajinda, Khemika Lomthaisong, and Wibhu Kutanan
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Genetics ,Cytochrome b ,Sequence analysis ,Medicine (miscellaneous) ,Dentistry (miscellaneous) ,Environmental Science (miscellaneous) ,Biology ,Agricultural and Biological Sciences (miscellaneous) ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Health Professions (miscellaneous) ,Gene - Published
- 2019
15. Paternal genetic history of the Yong population in northern Thailand revealed by Y-chromosomal haplotypes and haplogroups
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Wibhu Kutanan, Andrea Vágó-Zalán, Eszter Dudás, Anikó Galambos, Jatupol Kampuansai, and Horolma Pamjav
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0106 biological sciences ,0301 basic medicine ,Male ,Human Migration ,Population ,Ethnic group ,Genetic admixture ,Biology ,01 natural sciences ,DNA, Mitochondrial ,Haplogroup ,03 medical and health sciences ,Genetics ,Ethnicity ,Humans ,education ,China ,Molecular Biology ,education.field_of_study ,Chromosomes, Human, Y ,Haplotype ,Genetic Variation ,General Medicine ,Thailand ,humanities ,030104 developmental biology ,Genetics, Population ,Haplotypes ,Genetic structure ,Paternal Inheritance ,Ethnology ,Gene pool ,010606 plant biology & botany - Abstract
We have determined the distribution of Y-chromosomal haplotypes and haplogroups in the Yong population, one of the largest and well-known ethnic groups that began migrating southward from China to Thailand centuries ago. Their unique mass migration pattern provided great opportunities for researchers to study the genetic links of the transboundary migration movements among the peoples of China, Myanmar and Thailand. We analysed relevant male-specific markers, such as Y-STRs and Y-SNPs, and the distribution of 23 Y-STRs of 111 Yong individuals and 116 nearby ethnic groups including the Shan, Northern Thai, Lawa, Lua, Skaw, Pwo and Padong groups. We found that the general haplogroup distribution values were similar among different populations; however, the haplogroups O1b-M268 and O2-M112 constituted the vast majority of these values. In contrast with previous maternal lineage studies, the paternal lineage of the Yong did not relate to the Xishuangbanna Dai people, who represent their historically documented ancestors. However, they did display a close genetic affinity to other prehistoric Tai-Kadai speaking groups in China such as the Zhuang and Bouyei. Low degrees of genetic admixture within the populations who belonged to the Austroasiatic and Sino-Tibetan linguistic families were observed in the gene pool of the Yong populations. Resettlement in northern Thailand in the early part of the nineteenth century AD, by way of mass migration trend, was able to preserve the Yong's ancestral genetic background in terms of the way they had previously lived in China and Myanmar. Our study has revealed similar genetic structures among ethnic populations in northern Thailand and southern China, and has identified and emphasized an ancient Tai-Kadai patrilineal ancestry line in the Yong ethnic group.
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- 2019
16. Contrasting paternal and maternal genetic histories of Thai and Lao populations
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Leonardo Arias, Andrea Brunelli, Alexander Hübner, Silvia Ghirotto, Enrico Macholdt, Wibhu Kutanan, Jatupol Kampuansai, Roland Schröder, Metawee Srikummool, and Mark Stoneking
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0106 biological sciences ,Male ,Mitochondrial DNA ,Demographic history ,Human Migration ,MtDNA ,Socio-culturale ,Biology ,Y chromosome ,010603 evolutionary biology ,01 natural sciences ,Haplogroup ,Chromosomes ,03 medical and health sciences ,Demic diffusion ,Genetic variation ,Genetics ,LS8_2 ,Humans ,Tai-Kadai ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Discoveries ,030304 developmental biology ,Demography ,Language ,0303 health sciences ,Genetic diversity ,Family Characteristics ,Chromosomes, Human, Y ,Genome ,Austroasiatic ,Sino-Tibetan ,Female ,Genetic Variation ,Laos ,Thailand ,Genome, Mitochondrial ,Mitochondrial ,Ancient DNA ,Evolutionary biology ,Matrilocal residence ,Human - Abstract
The human demographic history of Mainland Southeast Asia (MSEA) has not been well studied; in particular, there have been very few sequence-based studies of variation in the male-specific portions of the Y chromosome (MSY). Here, we report new MSY sequences of ∼2.3 mB from 914 males and combine these with previous data for a total of 928 MSY sequences belonging to 59 populations from Thailand and Laos who speak languages belonging to three major Mainland Southeast Asia families: Austroasiatic, Tai-Kadai, and Sino-Tibetan. Among the 92 MSY haplogroups, two main MSY lineages (O1b1a1a* [O-M95*] and O2a* [O-M324*]) contribute substantially to the paternal genetic makeup of Thailand and Laos. We also analyze complete mitochondrial DNA genome sequences published previously from the same groups and find contrasting pattern of male and female genetic variation and demographic expansions, especially for the hill tribes, Mon, and some major Thai groups. In particular, we detect an effect of postmarital residence pattern on genetic diversity in patrilocal versus matrilocal groups. Additionally, both male and female demographic expansions were observed during the early Mesolithic (∼10 ka), with two later major male-specific expansions during the Neolithic period (∼4–5 ka) and the Bronze/Iron Age (∼2.0–2.5 ka). These two later expansions are characteristic of the modern Austroasiatic and Tai-Kadai groups, respectively, consistent with recent ancient DNA studies. We simulate MSY data based on three demographic models (continuous migration, demic diffusion, and cultural diffusion) of major Thai groups and find different results from mitochondrial DNA simulations, supporting contrasting male and female genetic histories.
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- 2019
17. Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand
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Piya Changmai, Pavel Flegontov, Enrico Macholdt, Jatupol Kampuansai, Daoroong Kangwanpong, Wibhu Kutanan, Roland Schröder, Alexander Hübner, and Mark Stoneking
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0301 basic medicine ,Mitochondrial DNA ,lcsh:Medicine ,030105 genetics & heredity ,Biology ,Y chromosome ,Southeast asian ,DNA, Mitochondrial ,Article ,Haplogroup ,03 medical and health sciences ,Asian People ,Genetic variation ,Humans ,lcsh:Science ,Transients and Migrants ,Genetics ,Genetic diversity ,Chromosomes, Human, Y ,Multidisciplinary ,Haplotype ,lcsh:R ,Genetic Variation ,Sequence Analysis, DNA ,Thailand ,030104 developmental biology ,Haplotypes ,Evolutionary biology ,lcsh:Q ,Human mitochondrial DNA haplogroup ,Founder effect - Abstract
The Maniq and Mlabri are the only recorded nomadic hunter-gatherer groups in Thailand. Here, we sequenced complete mitochondrial (mt) DNA genomes and ~2.364 Mbp of non- recombining Y chromosome (NRY) to learn more about the origins of these two enigmatic populations. Both groups exhibited low genetic diversity compared to other Thai populations, and contrasting patterns of mtDNA and NRY diversity: there was greater mtDNA diversity in the Maniq than in the Mlabri, while the converse was true for the NRY. We found basal uniparental lineages in the Maniq, namely mtDNA haplogroups M21a, R21 and M17a, and NRY haplogroup K. Overall, the Maniq are genetically similar to other negrito groups in Southeast Asia. By contrast, the Mlabri haplogroups (B5a1b1 for mtDNA and O1b1a1a1b and O1b1a1a1b1a1 for the NRY) are common lineages in Southeast Asian non-negrito groups, and overall the Mlabri are genetically similar to their linguistic relatives (Htin and Khmu) and other groups from northeastern Thailand. In agreement with previous studies of the Mlabri, our results indicate that the Malbri do not directly descend from the indigenous negritos. Instead, they likely have a recent origin (within the past 1,000 years) by an extreme founder event (involving just one maternal and two paternal lineages) from an agricultural group, most likely the Htin or a closely- related group.
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- 2018
18. Ancient genomes document multiple waves of migration in Southeast Asian prehistory
- Author
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Hoang Hiep Trinh, Kate Domett, Beatriz Gamarra, Thomas Oliver Pryce, David Reich, Mark Lipson, Olivia Cheronet, Eadaoin Harney, Ron Pinhasi, Aung Aung Kyaw, Piya Changmai, Mario Novak, Nadin Rohland, Pavel Flegontov, Anna Willis, Nasreen Broomandkhoshbacht, Zhao Zhang, Hallie R. Buckley, Daniel Fernandes, Kristin Stewardson, Francesca Candilio, Baptiste Pradier, Hirofumi Matsumura, Wibhu Kutanan, Swapan Mallick, Matthew Ferry, Marc Oxenham, Giang Hai Nguyen, Jonas Oppenheimer, Jatupol Kampuansai, Kendra Sirak, Tin Tin Win, Michael Pietrusewsky, Megan Michel, Harvard School of Public Health, Department of Anthropology [University of Vienna], University of Vienna [Vienna], School of Archaeology [Dublin], University College Dublin [Dublin] (UCD), School of Archaeology & Anthropology, Australian National University (ANU), Department of Anthropology University of Hawai'i at Manoa, University of Hawai‘i [Mānoa] (UHM), Laboratoire Archéomatériaux et Prévision de l'Altération (LAPA - UMR 3685), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Préhistoire et Technologie (PréTech), Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Sapporo Medical University, Department of Anatomy, University of Otago, Dunedin, University of Otago [Dunedin, Nouvelle-Zélande], James Cook University (JCU), Vietnam Institute of Archaeology, Hanoi, Vietnam., Department of Archaeology, Ministry of Culture, Ministry of Religious Affairs and Culture, Howard Hughes Medical Institute [Boston] (HHMI), Howard Hughes Medical Institute (HHMI)-Harvard Medical School [Boston] (HMS), Department of Anthropology [University of Pennsylvania], University of Pennsylvania [Philadelphia], Ostravská univerzita / University of Ostrava, Chiang Mai University (CMU), Khon Kaen University [Thailand] (KKU), Iowa State University (ISU), Department of Epidemiology and Public Health [university of Ostrava], Lékařská fakulta / Faculty of Medicine [University of Ostrava], Ostravská univerzita / University of Ostrava-Ostravská univerzita / University of Ostrava, School of Archaeology, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], and University of Pennsylvania
- Subjects
0301 basic medicine ,human migration ,Asia ,Population ,[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology ,Southeastern ,Southeast asian ,Article ,[SHS]Humanities and Social Sciences ,radiometric dating ,Prehistory ,03 medical and health sciences ,Asian People ,Bronze Age ,genetic variation ,genomics ,migration ,South East Asian prehistory ,prehistoric archaeology ,bioarchaeology ,0601 history and archaeology ,East Asia ,human ,DNA, Ancient ,agriculture ,Asian continental ancestry group ,DNA ,ancient ,history ,humans ,language ,genome ,multidisciplinary ,education ,Asia, Southeastern ,History, Ancient ,030304 developmental biology ,0303 health sciences ,education.field_of_study ,060101 anthropology ,060102 archaeology ,Human migration ,business.industry ,Genome, Human ,06 humanities and the arts ,030104 developmental biology ,Geography ,Ancient DNA ,Iron Age ,Period (geology) ,Ethnology ,business - Abstract
Ancient migrations in Southeast Asia The past movements and peopling of Southeast Asia have been poorly represented in ancient DNA studies (see the Perspective by Bellwood). Lipson et al. generated sequences from people inhabiting Southeast Asia from about 1700 to 4100 years ago. Screening of more than a hundred individuals from five sites yielded ancient DNA from 18 individuals. Comparisons with present-day populations suggest two waves of mixing between resident populations. The first mix was between local hunter-gatherers and incoming farmers associated with the Neolithic spreading from South China. A second event resulted in an additional pulse of genetic material from China to Southeast Asia associated with a Bronze Age migration. McColl et al. sequenced 26 ancient genomes from Southeast Asia and Japan spanning from the late Neolithic to the Iron Age. They found that present-day populations are the result of mixing among four ancient populations, including multiple waves of genetic material from more northern East Asian populations. Science , this issue p. 92 , p. 88 ; see also p. 31
- Published
- 2018
19. Erratum to: Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai-Kadai languages
- Author
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Wibhu Kutanan, Jatupol Kampuansai, Metawee Srikummool, Daoroong Kangwanpong, Silvia Ghirotto, Andrea Brunelli, and Mark Stoneking
- Subjects
Genetics ,Genetics (clinical) ,Original Investigation - Abstract
The Tai–Kadai (TK) language family is thought to have originated in southern China and spread to Thailand and Laos, but it is not clear if TK languages spread by demic diffusion (i.e., a migration of people from southern China) or by cultural diffusion, with native Austroasiatic (AA) speakers switching to TK languages. To address this and other questions, we obtained 1234 complete mtDNA genome sequences from 51 TK and AA groups from Thailand and Laos. We find high genetic heterogeneity across the region, with 212 different haplogroups, and significant genetic differentiation among different samples from the same ethnolinguistic group. TK groups are more genetically homogeneous than AA groups, with the latter exhibiting more ancient/basal mtDNA lineages, and showing more drift effects. Modeling of demic diffusion, cultural diffusion, and admixture scenarios consistently supports the spread of TK languages by demic diffusion. Electronic supplementary material The online version of this article (doi:10.1007/s00439-016-1742-y) contains supplementary material, which is available to authorized users.
- Published
- 2017
20. Y chromosomal evidence on the origin of northern Thai people
- Author
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Andrea Brunelli, Wibhu Kutanan, Mark Seielstad, Jatupol Kampuansai, Daoroong Kangwanpong, Silvia Ghirotto, Khemika Lomthaisong, and Caramelli, David
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Genetics and Molecular Biology (all) ,0301 basic medicine ,Male ,Thai People ,lcsh:Medicine ,Population genetics ,030105 genetics & heredity ,Biochemistry ,Haplogroup ,Geographical Locations ,Ethnicities ,lcsh:Science ,education.field_of_study ,Sex Chromosomes ,Multidisciplinary ,Chromosome Biology ,Simulation and Modeling ,Thailand ,Y Chromosomes ,Mitochondrial DNA ,Mitochondrial ,Nucleic acids ,Asians ,Geography ,Research Article ,Human ,Asian Continental Ancestry Group ,China ,Asia ,Forms of DNA ,General Science & Technology ,Population ,Socio-culturale ,Research and Analysis Methods ,DNA, Mitochondrial ,Chromosomes ,03 medical and health sciences ,Asian People ,Genetics ,Humans ,education ,Evolutionary Biology ,Chromosomes, Human, Y ,Genetic Variation ,Genetics, Population ,Haplotypes ,Microsatellite Repeats ,Biochemistry, Genetics and Molecular Biology (all) ,Agricultural and Biological Sciences (all) ,Population Biology ,lcsh:R ,Haplotype ,Biology and Life Sciences ,Genetic data ,Cell Biology ,DNA ,030104 developmental biology ,Southern china ,People and Places ,Haplogroups ,Population Groupings ,lcsh:Q ,Population Genetics ,Demography - Abstract
The Khon Mueang represent the major group of people present in today’s northern Thailand. While linguistic and genetic data seem to support a shared ancestry between Khon Mueang and other Tai-Kadai speaking people, the possibility of an admixed origin with contribution from local Mon-Khmer population could not be ruled out. Previous studies conducted on northern Thai people did not provide a definitive answer and, in addition, have largely overlooked the distribution of paternal lineages in the area. In this work we aim to provide a comprehensive analysis of Y paternal lineages in northern Thailand and to explicitly model the origin of the Khon Mueang population. We obtained and analysed new Y chromosomal haplogroup data from more than 500 northern Thai individuals including Khon Mueang, Mon-Khmer and Tai-Kadai. We also explicitly simulated different demographic scenarios, developed to explain the Khon Mueang origin, employing an ABC simulation framework on both mitochondrial and Y microsatellites data. Our results highlighted a similar haplogroup composition of Khon Mueang and Tai-Kadai populations in northern Thailand, with shared high frequencies of haplogroups O-PK4, O-M117 and O-M111. Our ABC simulations also favoured a model in which the ancestors of modern Khon Mueang originated recently after a split from the other Tai-Kadai populations. Our different analyses concluded that the ancestors of Khon Mueang are likely to have originated from the same source of the other Tai-Kadai groups in southern China, with subsequent admixture events involving native Mon-Khmer speakers restricted to some specific populations.
- Published
- 2017
21. Mitochondrial DNA-HVR1 Variation Reveals Genetic Heterogeneity in Thai-Isan Peoples from the Lower Region of Northeastern Thailand
- Author
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Artittaya Kamlao, Suparat Srithawong, Jatupol Kampuansai, and Wibhu Kutanan
- Subjects
Mitochondrial DNA ,education.field_of_study ,Genetic heterogeneity ,Population ,Genetic admixture ,Genetic relationship ,General Medicine ,Biology ,Hypervariable region ,stomatognathic diseases ,Evolutionary biology ,parasitic diseases ,Genetic variation ,Genetic structure ,education ,geographic locations ,Demography - Abstract
The Thai-Isan are the largest ethnic group in Northeastern Thailand, who migrated from the territory of present-day Laos around 200 years ago. There are a limited number of previous studies of mtDNA diversity in Northeastern Thai populations. The present study investigates genetic variation and genetic structure in three Thai-Isan populations by analyzing mitochondrial DNA variation in hypervariable region 1. We also evaluate genetic relationship and admixture between Thai-Isan and surrounding populations from Northeastern Thailand, and neighboring countries. The studied Thai-Isan populations reveal genetic differentiation from each other and from compared populations. Thai-Isan exhibit a close relationship with surrounding populations, particularly the Lao and Khmer, reflecting extensive gene flow among them. Admixture proportions observed in most Thai-Isan populations exhibit a higher contribution from the parental Lao than the Khmer. Different admixture patterns reflect genetic heterogeneity of Thai-Isan groups. The lower the latitude, the higher the Khmer contribution might be associated with the ethnic constitution of parental populations in each Thai-Isan population. More genetic data from HVR2 and coding regions, as well as different marker systems are needed to infer population history of Thai-Isan populations.
- Published
- 2014
22. Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai-Kadai languages
- Author
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Wibhu Kutanan, Metawee Srikummool, Mark Stoneking, Andrea Brunelli, Silvia Ghirotto, Daoroong Kangwanpong, and Jatupol Kampuansai
- Subjects
0301 basic medicine ,Mitochondrial DNA ,China ,Genetics ,Genetics (clinical) ,Population ,Socio-culturale ,030105 genetics & heredity ,Biology ,Genome ,DNA, Mitochondrial ,Haplogroup ,03 medical and health sciences ,Demic diffusion ,Genetic variation ,Ethnicity ,Humans ,Genetics(clinical) ,education ,Language ,education.field_of_study ,Genetic heterogeneity ,Haplotype ,Genetic Variation ,Sequence Analysis, DNA ,Thailand ,030104 developmental biology ,Genetics, Population ,Logistic Models ,Southern china ,Haplotypes ,Homogeneous ,Evolutionary biology ,Genome, Mitochondrial ,Language family ,Erratum ,Sequence Alignment - Abstract
The Tai-Kadai (TK) language family is thought to have originated in southern China and spread to Thailand and Laos, but it is not clear if TK languages spread by demic diffusion (i.e., a migration of people from southern China) or by cultural diffusion, with native Austroasiatic (AA) speakers switching to TK languages. To address this and other questions, we obtained 1,234 complete mtDNA genome sequences from 51 TK and AA groups from Thailand and Laos. We find high genetic heterogeneity, with 212 haplogroups. TK groups are more genetically homogeneous than AA groups, with the latter exhibiting more ancient/basal mtDNA lineages, and showing more drift effects. Modeling of demic diffusion, cultural diffusion, and admixture scenarios consistently supports the spread of TK languages by demic diffusion. Surprisingly, there is significant genetic differentiation within ethnolinguistic groups, calling into question the common assumption that there is genetic homogeneity within ethnolinguistic groups.
- Published
- 2016
23. Effect of migration patterns on maternal genetic structure: a case of Tai-Kadai migration from China to Thailand
- Author
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Daoroong Kangwanpong, Massupa Kaewgahya, Wibhu Kutanan, Silvia Ghirotto, Jatupol Kampuansai, and Francesca Tassi
- Subjects
0106 biological sciences ,0301 basic medicine ,Genetic Markers ,Mitochondrial DNA ,China ,Human Migration ,Socio-culturale ,Close relatives ,Biology ,010603 evolutionary biology ,01 natural sciences ,DNA, Mitochondrial ,03 medical and health sciences ,Effective population size ,Genetics ,Humans ,Genetics (clinical) ,Analysis of Variance ,Genetic heterogeneity ,Thailand ,Hypervariable region ,030104 developmental biology ,Genetics, Population ,Haplotypes ,Evolutionary biology ,Genetic structure ,Founder effect - Abstract
The migration of the Tai-Kadai speaking people from southern China to northern Thailand over the past hundreds of years has revealed numerous patterns that have likely been influenced by routes, purposes and periods of time. To study the effects of different migration patterns on Tai-Kadai maternal genetic structure, mitochondrial DNA hypervariable region I sequences from the Yong and the Lue people having well-documented histories in northern Thailand were analyzed. Although the Yong and Lue people were historically close relatives who shared Xishuangbanna Dai ancestors, significant genetic differences have been observed among them. The Yong people who have been known to practice mass migration have exhibited a closer genetic affinity to their Dai ancestors than have the Lue people. Genetic heterogeneity and a sudden reduced effective population size within the Lue group is likely a direct result of the circumstances of the founder effect.
- Published
- 2016
24. Autosomal STR variations reveal genetic heterogeneity in the Mon-Khmer speaking group of Northern Thailand
- Author
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Horolma Pamjav, Daoroong Kangwanpong, Antónia Völgyi, Wibhu Kutanan, and Jatupol Kampuansai
- Subjects
0106 biological sciences ,0301 basic medicine ,Ethnic group ,Genetic admixture ,010603 evolutionary biology ,01 natural sciences ,Indigenous ,Pathology and Forensic Medicine ,Prehistory ,03 medical and health sciences ,Genetic Heterogeneity ,Gene Frequency ,Genetics ,Ethnicity ,Humans ,Colonization ,Thailand ,DNA Fingerprinting ,030104 developmental biology ,Geography ,Ethnology ,Gene pool ,Rural area ,Multiplex Polymerase Chain Reaction ,Founder effect ,Microsatellite Repeats - Abstract
Since prehistoric times, Mon-Khmer speaking people have been recognized as indigenous ethnic groups living in northern Thailand. After the period of Tai colonization in the thirteenth century CE, the Mon-Khmer inhabitants were fragmented; some were expelled to rural areas while some were integrated into the mainstream of Tai society. Autosomal STR variations revealed that the present-day Mon-Khmer people could be genetically divided into two clusters. This finding appears to be consistent with the level of historical contact with the Tai majority ethnic groups. The cluster consisting of the Khamu, Lua, Paluang and Htin people, indicate that they have lived in remote areas and have had little historical contact with the Tai people. In this way, they appeared to have maintained aspects of their Mon-Khmer ancestral genetic bloodline but have genetically diverged from the Tai people. The cluster comprised of the Mon and Lawa people had an exclusively close relationship with the Tai people during the establishment of the prosperous Lan Na Kingdom. A fraction of the Tai genetic component investigated among the Mon people and some Lawa populations reflected the evidence of genetic admixture. However, some Lawa people, who have lived in the mountainous area of Mae Hong Son Province have exhibited a unique gene pool, which might have been shaped by the founder effect that occurred during their historical fragmentation. The rise of the genetic assimilation of the hill-tribe Karen people into the Mon-Khmer and the Tai gene pools indicated that different languages, cultures, and geographical distances have lost their power as barriers of inter-ethnic marriages in the present day.
- Published
- 2016
25. Maternal Genetic History of the Mon in Thailand
- Author
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Wibhu Kutanan, Metawee Srikummool, Jatupol Kampuansai, and Pittayawat Pittayaporn
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,Medicine (miscellaneous) ,Dentistry (miscellaneous) ,Environmental Science (miscellaneous) ,Biology ,Agricultural and Biological Sciences (miscellaneous) ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Health Professions (miscellaneous) - Published
- 2016
26. Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci
- Author
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Supaporn Nakbunlung, Vincenza Colonna, Wibhu Kutanan, Pornpilai Lertvicha, Giorgio Bertorelle, Daoroong Kangwanpong, Mark Seielstad, and Jatupol Kampuansai
- Subjects
Male ,khon mueang ,Mitochondrial DNA ,migration route ,Population ,Genetic admixture ,autosomal STR ,DNA, Mitochondrial ,Asian People ,Population Groups ,Ethnicity ,Genetics ,Humans ,education ,Genetics (clinical) ,Language ,genetic admixture ,genetic affinity ,education.field_of_study ,Geography ,Genetic data ,Emigration and Immigration ,Thailand ,Evolutionary biology ,Str loci ,Microsatellite ,Female ,Microsatellite Repeats - Abstract
The Khon Mueang (KM) are the largest group of northern Thai people. Our previous mtDNA studies have suggested an admixture process among the KM with the earlier Mon-Khmer-speaking inhabitants of this region. In this study, we evaluate genetic affinities and admixture among 10 KM populations in northern Thailand lying along the historical Yuan migration route, and 10 neighboring populations belonging to 7 additional ethnic groups: Lawa, Mon (Mon-Khmer-speaking groups), Shan, Yuan, Lue, Khuen and Yong (Tai-speaking groups) by analyzing 15 hypervariable autosomal short tandem repeat loci. The KM exhibited close relationships with neighboring populations, especially the Tai-speaking groups, reflecting an admixed origin of the KM. Admixture proportions were observed in all KM populations, which had a higher contribution from the parental Tai than the Mon-Khmer groups. Different admixture patterns of the KM along the migration route might indicate high heterogeneity among the KM. These patterns were not directly associated with geographical proximity, suggesting other factors, like variation in the timing of admixture with the existing populations may have had an important role. More genetic data from different marker systems solely transmitted through the male or female lineages are needed to complete the description of genetic admixture and population history of the KM. © 2011 The Japan Society of Human Genetics All rights reserved.
- Published
- 2010
27. Genetic and linguistic correlation of the Kra-Dai-speaking groups in Thailand
- Author
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Silvia Ghirotto, Jie Sun, Arthur J. Eisenberg, Wibhu Kutanan, Metawee Srikummool, Ranajit Chakraborty, Panuwan Chantawannakul, Pittayawat Pittayaporn, and Suparat Srithawong
- Subjects
Heterozygote ,Human Migration ,Population ,Population genetics ,Socio-culturale ,Biology ,Genetic drift ,Genetic ,Models ,Genetic variation ,Genetics ,Humans ,education ,Genetics (clinical) ,Language ,Genetic diversity ,education.field_of_study ,Models, Genetic ,Medicine (all) ,Genetic Drift ,Genetic Variation ,Bayes Theorem ,Thailand ,Linguistics ,Genetic epidemiology ,Genetic structure ,Mantel test - Abstract
The Kra-Dai linguistic family includes Thai and Lao as well as a great number of languages spoken by ethnic minorities in Southeast Asia. In Thailand, a dozen of other Kra-Dai languages are spoken in addition to Thai, the national language. The genetic structure of the Kra-Dai-speaking populations in Thailand has been studied extensively using uniparentally inherited markers. To extend this line of genetic investigation, this study used 15 autosomal microsatellites of 500 individuals from 11 populations, belonging to nine Kra-Dai ethnicities, namely, the Kaleung, Phu Thai, Saek, Nyo, Lao Isan, Yuan, Black Tai, Phuan and Lue. These ethnolinguistic groups are dispersed in three different geographic regions of Thailand, that is, Northern, Northeastern and Central. The results show a very low average of pairwised F(st) (0.0099), as well as no population substructure based on STRUCTURE analysis, indicating genetic homogeneity within the Kra-Dai-speaking group, possibly owing to shared linguistic ancestry. The Mantel test, an analysis of molecular variance, and the approximate Bayesian computation procedure employed to evaluate potential factors for driving genetic diversity revealed that language is the predominant factor affecting genetic variations, whereas geography is not. The result of distance-based clustering analyses and spatial analysis of molecular variance revealed genetic distinctions of some populations, reflecting the effects of genetic drift and gene flow on allele frequency within populations, in concordance with the result of R-matrix regression. The genetic and linguistic affiliations of the contemporary Kra-Dai-speaking groups are consistent with each other despite certain deviation due to various evolutionary factors that may have occurred during their migrations and resettlements.
- Published
- 2014
28. Thai Twin Registry: Description of the Initial Stage
- Author
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Kusuma Chusilp, Somsong Nanakorn, and Wibhu Kutanan
- Subjects
Adult ,Male ,Ulnar loop ,Adolescent ,Biology ,Cohort Studies ,Fingers ,Young Adult ,Diseases in Twins ,Twins, Dizygotic ,Humans ,Registries ,Dermatoglyphics ,Child ,Genetics (clinical) ,Whorl (botany) ,Aged ,Orthodontics ,Obstetrics and Gynecology ,Twins, Monozygotic ,Middle Aged ,Ridge count ,Thailand ,Twin study ,Zygosity ,Right little finger ,Phenotype ,ROC Curve ,Initial phase ,Pediatrics, Perinatology and Child Health ,Female - Abstract
The present study describes the initial phase of the Thai Twin Registry (TTR) in Khon Kaen University, a pioneer research university located in the Northeast of Thailand. The initial steps of the study included the analysis of dermatoglyphic information in Thai twins for answering the research question: Are monozygotic (MZ) and dizygotic (DZ) twins different in dermatoglyphic variables? Subjects were 212 twin pairs (81 MZ and 131 DZ), consisting of 155 males and 269 females. Four types of fingerprint pattern (FP) — that is, arch, radial loop, ulnar loop, and whorl — were classified and analyzed and compared between MZ and DZ twins. The arch radial loop and whorl frequencies differ between MZ and DZ twins. When comparing FP in each finger, only the right little finger shows a statistically different FP, while the FP similarity average from 10 homologous fingers of co-twins was greater in MZ than DZ twins. By using the Area Under the Receiver Operating Characteristic curve analysis, the MZ twins could be differentiated from DZ twins by the FP similarity. Summarizing, this valuable report about TTR was conducted by analysis of FP data, which indicated that the MZ and DZ twins exhibited FP pattern and FP similarity differences. Other dermatoglyphic studies of the existing FP database, such as finger ridge count, finger ridge density, and minutia, will be considered for ongoing research at the TTR.
- Published
- 2012
29. Forensic STR loci reveal common genetic ancestry of the Thai-Malay Muslims and Thai Buddhists in the deep Southern region of Thailand
- Author
-
Sukanya Phetpeng, Wibhu Kutanan, Thitika Kitpipit, and Phuvadol Thanakiatkrai
- Subjects
Genetics ,Genetic genealogy ,Genetic admixture ,Biology ,Thailand ,language.human_language ,Forensic science ,Religion ,Cultural barriers ,Evolutionary biology ,Genetic structure ,language ,Str loci ,Ethnicity ,Microsatellite ,Humans ,Genetics (clinical) ,Malay ,Microsatellite Repeats - Abstract
Among the people living in the five deep Southern Thai provinces, Thai-Malay Muslims (MUS) constitute the majority, while the remaining are Thai Buddhists (BUD). Cultural, linguistic and religious differences between these two populations have been previously reported. However, their biological relationship has never been investigated. In this study, we aimed to reveal the genetic structure and genetic affinity between MUS and BUD by analyzing 15 autosomal short tandem repeats. Both distance and model-based clustering methods showed significant genetic homogeneity between these two populations, suggesting a common biological ancestry. After Islamization in this region during the fourteenth century AD, gradual albeit nonstatistically significant genetic changes occurred within these two populations. Cultural barriers possibly influenced these genetic changes. MUS have closer admixture to Malaysian-Malay Muslims than BUD countrywide. Admixture proportions also support certain degree of genetic dissimilarity between the two studied populations, as shown by the unequal genetic contribution from Malaysian-Malay Muslims. Cultural transformation and recent minor genetic admixture are the likely processes that shaped the genetic structure of both MUS and BUD.
- Published
- 2014
30. An Updated Phylogeny of the Human Y-Chromosome Lineage O2a-M95 with Novel SNPs
- Author
-
Tuot Sovannary, Hong Shi, Li Jin, Wibhu Kutanan, Shiyu Liao, Jatupol Kampuansai, Bun Serey, Xiaoming Zhang, Xin Luo, Ham Samnom, Long Bunnath, Xuebin Qi, Hong Seang Aun, Bing Su, Zhaohui Yang, Daoroong Kangwanpong, and Shi Yan
- Subjects
Male ,China ,Population ,lcsh:Medicine ,Single-nucleotide polymorphism ,Biology ,Y chromosome ,Polymorphism, Single Nucleotide ,Haplogroup ,Phylogenetics ,Genetics ,SNP ,Humans ,lcsh:Science ,education ,Phylogeny ,education.field_of_study ,Evolutionary Biology ,Multidisciplinary ,Chromosomes, Human, Y ,Phylogenetic tree ,Population Biology ,lcsh:R ,Paleogenetics ,Biology and Life Sciences ,Human Genetics ,Thailand ,lcsh:Q ,Cambodia ,Population Genetics ,Research Article - Abstract
Though the Y-chromosome O2a-M95 lineage is one of the major haplogroups present in eastern Asian populations, especially among Austro-Asiatic speaking populations from Southwestern China and mainland Southeast Asia, to date its phylogeny lacks structure due to only one downstream SNP marker (M88) assigned to the lineage. A recent array-capture-based Y chromosome sequencing of Asian samples has yielded a variety of novel SNPs purportedly belonging to the O2a-M95 lineage, but their phylogenetic positions have yet to be determined. In this study, we sampled 646 unrelated males from 22 Austro-Asiatic speaking populations from Cambodia, Thailand and Southwestern China, and genotyped 12 SNP makers among the sampled populations, including 10 of the newly reported markers. Among the 646 males, 343 belonged to the O2a-M95 lineage, confirming the supposed dominance of this Y chromosome lineage in Austro-Asiatic speaking populations. We further characterized the phylogeny of O2a-M95 by defining 5 sub-branches: O2a1*-M95, O2a1a-F789, O2a1b*-F1252, O2a1b1*-M88 and O2a1b1a -F761. This updated phylogeny not only improves the resolution of this lineage, but also allows for greater tracing of the prehistory of human populations in eastern Asia and the Pacific, which may yield novel insights into the patterns of language diversification and population movement in these regions.
- Published
- 2014
31. โครโมโซมวายกับการศึกษาวิวัฒนาการของมนุษย์ (Y chromosome and the study of human evolution)
- Author
-
Wibhu Kutanan and Daoroong Kangwanpong
- Subjects
โครโมโซมวาย, แฮโปลกรุ๊ป, เชื้อสาย, วิวัฒนาการของมนุษย์, เอเชียตะวันออก, Y chromosome, haplogroup, lineage, human evolution, East Asia - Abstract
2, 7, Thai Journal of Genetics
- Published
- 2014
- Full Text
- View/download PDF
32. Variability of Finger Ridge Density among Thai Adolescents
- Author
-
Somsong Nanakorn and Wibhu Kutanan
- Subjects
Orthodontics ,geography ,Core (anatomy) ,Bayes' theorem ,geography.geographical_feature_category ,business.industry ,Ridge ,Word processing ,Posterior probability ,Fingerprint image ,Medicine ,Artificial intelligence ,business - Abstract
Finger ridge density (RD) is the number of finger ridges that touch the diagonal line drawn between a square of 25 mm2 which is placed on the core of the fingerprint image. It has been useful as a sex determination aid in forensic practice as its values are significantly higher in females than males. The present study was aimed at investigating the RD of Thai adolescents aged between 10 and 12 years old. Subjects were 130 schoolboys and 130 schoolgirls were randomly selected and signed informed consent forms prior to printing each individual’s ten fingers by using the adhesive transparent tape technique. The Microsoft Word program was applied for precise counting of RD. The mean RD differences between left and right hands, boys and girls, radial and ulnar areas were statistically tested. The likelihood ratio was computed to obtain the probability inferences of sex, and posterior probabilities were estimated using Bayes’ theorem. Results revealed as follows: (1) The mean RDs (ridges per 25 mm2) of boys and girls were not significantly different across the radial (15.89 vs. 16.19, respectively) and ulnar areas (15.84 vs. 16.00, respectively). For each sex, mean RDs in the radial and the ulnar were not statistically different. (2) The mean RDs in both sexes were greater in the left hand fingers compared to the right hand, and were statistically significant only in girls. (3) For the ulnar area, the RD of 13 or less is most likely to be of from male origin and that of 17 or more has a low probability of being of female origin. Comparing the radial area, an RD of 14 or less has a low probability of being of male origin while a weak probability of the RD of 17 or more is most likely being of female origin.
- Published
- 2012
33. Genetic structure of the ethnic populations Lua and H
- Author
-
Wibhu Kutanan and Daoroong Kangwanpong
- Subjects
Lua, H?tin, genetic structure, Y-chromosomal microsatellite, mtDNA - Abstract
2, 3, Thai Journal of Genetics
- Published
- 2010
- Full Text
- View/download PDF
34. Increasing the discrimination power of a mitochondrial DNA control region by using hypervariable region 2 polymorphisms, as illustrated in Tai populations of Northern Thailand
- Author
-
Chaiwat Kriengchutima, Nadchanok Rodrussamee, Wibhu Kutanan, and Jatupol Kampuansai
- Subjects
Multidisciplinary - Published
- 2015
35. Thai Twin Registry: Description of the Initial Stage — Corrigendum
- Author
-
Wibhu Kutanan, Somsong Nanakorn, and Kusuma Chusilp
- Subjects
medicine.medical_specialty ,business.industry ,General surgery ,Pediatrics, Perinatology and Child Health ,medicine ,Obstetrics and Gynecology ,Stage (hydrology) ,business ,Genetics (clinical) - Published
- 2013
36. Determination of sex difference from fingerprint ridge density in northeastern Thai teenagers
- Author
-
Pattanawit Soanboon, Somsong Nanakorn, and Wibhu Kutanan
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Health (social science) ,Fingerprint ,Biology ,Thais ,01 natural sciences ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Age groups ,Thai population ,Northeastern Thai teenagers ,lcsh:Law in general. Comparative and uniform law. Jurisprudence ,030216 legal & forensic medicine ,Sexual difference ,geography ,lcsh:R5-920 ,geography.geographical_feature_category ,010401 analytical chemistry ,Ridge density (RD) ,Sex determination ,biology.organism_classification ,Genealogy ,0104 chemical sciences ,Forensic science ,Ridge ,lcsh:K1-7720 ,lcsh:Medicine (General) ,Law ,Demography - Abstract
Although, there has already been much research on the differences between sexes in fingerprint ridge density and its variability in the Thai population, such studies have not included native northeastern Thais aged between 14 and 24 who are descended from northeastern Thai ancestry. This study intends to determine the topological, age-grouping and sexual differences in fingerprint ridge density (RD) in such populations. Fingerprints were collected from 353 unrelated volunteers (191 males and 162 females) and classified into three groups, that is, group A (total subjects), group B (14–18 years old) and group C (18–24 years old). RD was assessed for two topological areas, radial and ulnar. Significant differences between genders and age groups were obtained in both counting areas. Females exhibit higher RD i.e. narrower ridges, than males. A decrease in RD values with increasing age was also detected. The RD threshold for discrimination of sexes, computed based on Bayes’ theorem, was achieved in all groups and counting areas, enabling its use in forensic investigation.
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37. Genetic structure of the Mon-Khmer speaking groups and their affinity to the neighbouring Tai populations in Northern Thailand
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Giorgio Bertorelle, Mark Seielstad, Supaporn Nakbunlung, Jatupol Kampuansai, Wibhu Kutanan, Daoroong Kangwanpong, and Silvia Fuselli
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Male ,Mitochondrial DNA ,Genotype ,lcsh:QH426-470 ,Molecular Sequence Data ,Biology ,DNA, Mitochondrial ,Polymorphism, Single Nucleotide ,Population Groups ,Geographical distance ,Genetic variation ,Genetics ,Humans ,Genetics(clinical) ,Genetics (clinical) ,Language ,Chromosomes, Human, Y ,Base Sequence ,Bayes Theorem ,Thailand ,Genetic divergence ,lcsh:Genetics ,Genetics, Population ,Southern china ,Genetic Loci ,Close relationship ,Genetic structure ,Female ,Microsatellite Repeats ,Research Article - Abstract
BackgroundThe Mon-Khmer speaking peoples inhabited northern Thailand before the arrival of the Tai speaking people from southern China in the thirteenth century A.D. Historical and anthropological evidence suggests a close relationship between the Mon-Khmer groups and the present day majority northern Thai groups. In this study, mitochondrial and Y-chromosomal DNA polymorphisms in more than 800 volunteers from eight Mon-Khmer and ten Tai speaking populations were investigated to estimate the degree of genetic divergence between these major linguistic groups and their internal structure.ResultsA large fraction of genetic variation is observed within populations (about 80% and 90% for mtDNA and the Y-chromosome, respectively). The genetic divergence between populations is much higher in Mon-Khmer than in Tai speaking groups, especially at the paternally inherited markers. The two major linguistic groups are genetically distinct, but only for a marginal fraction (1 to 2%) of the total genetic variation. Genetic distances between populations correlate with their linguistic differences, whereas the geographic distance does not explain the genetic divergence pattern.ConclusionsThe Mon-Khmer speaking populations in northern Thailand exhibited the genetic divergence among each other and also when compared to Tai speaking peoples. The different drift effects and the post-marital residence patterns between the two linguistic groups are the explanation for a small but significant fraction of the genetic variation pattern within and between them.
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