71 results on '"Viehöfer, A."'
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2. NVH-Simulator - Ein Weg zum digitalen Zwilling
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Bernd Philippen, Marius Dute, Jens Viehöfer, and Michael Bruss
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Automotive Engineering - Published
- 2023
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3. Instabilität des oberen Sprunggelenks
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Arnd Viehöfer, Marlene Mauch, and Nicola Krähenbühl
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Orthopedics and Sports Medicine - Abstract
ZusammenfassungDie symptomatische Bandinstabilität des oberen Sprunggelenks (OSG) ist eine häufige Pathologie und bedarf bei gescheiterter konservativer Therapie oft einer operativen Stabilisierung. Neben Anamnese und subjektiver Wahrnehmung des Patienten liefern klinische Untersuchung, funktionelle Diagnostik, Bildgebung und je nach Bedarf die Arthroskopie des Sprunggelenks wichtige Informationen. Meistens benötigt es eine Kombination mehrerer Untersuchungsmethoden, um die Diagnose einer behandlungsbedürftigen OSG-Instabilität zu stellen. Neben der Beurteilung der Stabilität ist ebenfalls die Feststellung von Zusatzpathologien wichtig. Dies beinhaltet auch das Erkennen einer pathologischen Rückfußachse, was essenziell für die weitere Behandlung sein kann. Die operative Therapie kann mittels Arthroskopie oder offener Operation mit weitgehend erfreulichen klinischen Resultaten durchgeführt werden.
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- 2023
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4. Risk Factors for Surgical Site Infections in Elective Orthopedic Foot and Ankle Surgery: The Role of Diabetes Mellitus
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Laura Soldevila-Boixader, Arnd Viehöfer, Stephan Wirth, Felix Waibel, Inci Yildiz, Mike Stock, Peter Jans, and Ilker Uçkay
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Diabetis ,diabetic patients ,Diabetes ,Complications of surgery ,General Medicine ,surgical site infection ,elective orthopedic surgery ,Complicacions quirúrgiques - Abstract
Surgical site infection (SSI) after elective orthopedic foot and ankle surgery is uncommon and may be higher in selected patient groups. Our main aim was to investigate the risk factors for SSI in elective orthopedic foot surgery and the microbiological results of SSI in diabetic and non-diabetic patients, in a tertiary foot center between 2014 and 2022. Overall, 6138 elective surgeries were performed with an SSI risk of 1.88%. The main independent associations with SSI in a multivariate logistic regression analysis were an ASA score of 3–4 points, odds ratio (OR) 1.87 (95% confidence interval (CI) 1.20–2.90), internal, OR 2.33 (95% CI 1.56–3.49), and external material, OR 3.08 (95% CI 1.56–6.07), and more than two previous surgeries, OR 2.86 (95% CI 1.93–4.22). Diabetes mellitus showed an increased risk in the univariate analysis, OR 3.94 (95% CI 2.59–5.99), and in the group comparisons (three-fold risk). In the subgroup of diabetic foot patients, a pre-existing diabetic foot ulcer increased the risk for SSI, OR 2.99 (95% CI 1.21–7.41), compared to non-ulcered diabetic patients. In general, gram-positive cocci were the predominant pathogens in SSI. In contrast, polymicrobial infections with gram-negative bacilli were more common in contaminated foot surgeries. In the latter group, the perioperative antibiotic prophylaxis by second-generation cephalosporins did not cover 31% of future SSI pathogens. Additionally, selected groups of patients revealed differences in the microbiology of the SSI. Prospective studies are required to determine the importance of these findings for optimal perioperative antibiotic prophylactic measures.
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- 2023
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5. Ulcer occurrence on adjacent toes and hallux valgus deformity after amputation of the second toe in diabetic patients
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Ines Unterfrauner, Octavian Andronic, Arnd F. Viehöfer, Stephan H. Wirth, Martin C. Berli, and Felix W. A. Waibel
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Orthopedics and Sports Medicine ,Surgery - Abstract
Background Amputation of the second toe is associated with destabilization of the first toe. Possible consequences are hallux valgus deformity and subsequent pressure ulcers on the lateral side of the first or on the medial side of the third toe. The aim of this study was to investigate the incidence and possible influencing factors of interdigital ulcer development and hallux valgus deformity after second toe amputation. Methods Twenty-four cases of amputation of the second toe between 2004 and 2020 (mean age 68 ± 12 years; 79% males) were included with a mean follow-up of 36 ± 15 months. Ulcer development on the first, third, or fourth toe after amputation, the body mass index (BMI) and the amputation level (toe exarticulation versus transmetatarsal amputation) were recorded. Pre- and postoperative foot radiographs were evaluated for the shape of the first metatarsal head (round, flat, chevron-type), the hallux valgus angle, the first–second intermetatarsal angle, the distal metatarsal articular angle and the hallux valgus interphalangeal angle by two orthopedic surgeons for interobserver reliability. Results After amputation of the second toe, the interdigital ulcer rate on the adjacent toes was 50% and the postoperative hallux valgus rate was 71%. Neither the presence of hallux valgus deformity itself (r = .19, p = .37), nor the BMI (r = .09, p = .68), the shape of the first metatarsal head (r = − .09, p = .67), or the amputation level (r = .09, p = .69) was significantly correlated with ulcer development. The interobserver reliability of radiographic measurements was high, oscillating between 0.978 (p = .01) and 0.999 (p = .01). Conclusions The interdigital ulcer rate on the first or third toe after second toe amputation was 50% and hallux valgus development was high. To date, evidence on influencing factors is lacking and this study could not identify parameters such as the BMI, the shape of the first metatarsal head or the amputation level as risk factors for the development of either hallux valgus deformity or ulcer occurrence after second toe amputation. Trial Registration: BASEC-Nr. 2019-01791
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- 2023
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6. A novel approach for joint line restoration in revision total ankle arthroplasty based on the three-dimensional registration of the contralateral tibia and fibula
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S. Hodel, A. K. Calek, N. Cavalcanti, S. F. Fucentese, L. Vlachopoulos, A. Viehöfer, and S. H. Wirth
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Orthopedics and Sports Medicine - Abstract
Purpose The use of total ankle arthroplasty (TAA) is increasing over time, as so will the need for revision TAAs in the future. Restoration of the ankle joint line (JL) in revision TAA is often difficult due to severe bone loss. This study analyzed the accuracy of a three-dimensional (3D) registration of the contralateral tibia and fibula to restore the ankle joint line (JL) and reported side-to-side differences of anatomical landmarks. Methods 3D triangular surface models of 96 paired lower legs underwent a surface registration algorithm for superimposition of the mirrored contralateral lower leg onto the original lower leg to approximate the original ankle JL using a proximal, middle and distal segment. Distances of the distal fibular tip, anterior and posterior medial colliculus to the JL were measured and absolute side-to-side differences reported. Anterior lateral distal tibial angle (ADTA) and lateral distal tibial angle (LDTA) were measured. Results Mean JL approximation was most accurate for the distal segment (0.1 ± 1.4 mm (range: -3.4 to 2.8 mm)) and middle segment (0.1 ± 1.2 mm (range: -2.8 to 2.5 mm)) compared to the proximal segment (-0.2 ± 1.6 mm (range: -3.0 to 4.9 mm)) (p = 0.007). Distance of the distal fibular tip, the anterior, and posterior medial colliculus to the JL, ADTA and LDTA yielded no significant side-to-side differences (n.s.). Conclusion 3D registration of the contralateral tibia and fibula reliably approximated the original ankle JL. The contralateral distal fibular tip, anterior and posterior medial colliculi, ADTA and LDTA can be used reliably for the planning of revision TAA with small side-to-side differences reported. Level of Evidence IV.
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- 2023
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7. The Relationship between Frontal, Axial Leg Alignment, and Ankle Joint Line Orientation-a Radiographic Analysis of Healthy Subjects
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Sandro Hodel, Nicola Cavalcanti, Sandro Fucentese, Lazaros Vlachopoulos, Arnd Viehöfer, Stephan Wirth, University of Zurich, and Hodel, Sandro
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2732 Orthopedics and Sports Medicine ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Orthopedics and Sports Medicine ,Surgery ,2746 Surgery - Abstract
Ankle joint line orientation (AJLO) is influenced by the subtalar foot and frontal leg alignment. However, the influence of axial leg alignment on AJLO remains unclear. The study aimed to analyze the influence of frontal, axial leg alignment on AJLO in healthy subjects.Thirty healthy subjects (60 legs) without prior surgery underwent standing biplanar long leg radiograph (LLR) between 2016 and 2020. AJLO was measured in standing long-leg radiographs relative to the ground. Meary's angle and calcaneal pitch were measured. Hip-knee-ankle angle (HKA), femoral antetorsion, and tibial torsion were assessed with SterEOS software (EOS Imaging, Paris, France). LLR was acquired with the feet directing straight anteriorly, which corresponds to a neutral foot progression angle (FPA). The influence of subtalar, frontal, and axial alignment on AJLO was analyzed in a multiple regression model.An increase in knee valgus increased relative valgus AJLO by 0.5° (95% CI: 0.2° to 0.7°) per 1° (P 0.001). A decrease in femoral antetorsion increased relative valgus AJLO by 0.2° (95% CI: 0.1° to 0.2°) per 1° (P 0.001), whereas Meary's angle and calcaneal pitch did not influence AJLO.A link between frontal, axial leg alignment, and AJLO could be demonstrated, indicating that a valgus leg alignment and relative femoral retrotorsion are associated with an increase of valgus AJLO in healthy subjects when placing their feet in a neutral position. Alteration of the frontal, or rotational profile after realignment surgery or by implant positioning might influence the AJLO, when the FPA is kept constant.
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- 2022
8. Outcomes of Tibialis Anterior Tendon Reconstruction with Autograft or Allograft
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Benjamin Fritz, Octavian Andronic, Florian B. Imhoff, Stefan Fröhlich, Stephan H. Wirth, Arnd F. Viehöfer, Ines Unterfrauner, Lukas Jud, University of Zurich, and Imhoff, Florian B
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medicine.medical_specialty ,610 Medicine & health ,Tendon reconstruction ,Transplantation, Autologous ,Tendons ,03 medical and health sciences ,2732 Orthopedics and Sports Medicine ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Autografts ,Interposition graft ,Retrospective Studies ,030222 orthopedics ,business.industry ,030229 sport sciences ,Tendon rupture ,Allografts ,medicine.disease ,Tibialis anterior tendon ,2746 Surgery ,Tendon ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Ankle ,Tendinopathy ,business - Abstract
Background: In cases of tibialis anterior tendon (TAT) ruptures associated with significant tendon defect, an interposition graft is often needed for reconstruction. Both auto- and allograft reconstructions have been described in the literature. Our hypothesis was that both graft types would have a good integrity and provide comparable outcomes. Methods: Patients who underwent TAT reconstruction using either an auto- or allograft were identified. Patient-reported outcomes (PROs) were collected using the 12-Item Short Form Health Survey (SF-12) questionnaire, the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score, the Foot Function Index (FFI), and the Karlsson-Peterson score. Functional outcome was assessed by isokinetic strength measurement. Outcomes were further assessed with magnetic resonance imaging (MRI) evaluation of graft integrity. All measurements were also performed for the contralateral foot. Results: Twenty-one patients with an average follow-up of 82 months (20-262 months), comprising 12 allograft and 9 autograft TAT reconstructions, were recruited. There were no significant differences in patient-reported outcomes between allograft reconstructions and autografts: SF-12 (30.7 vs 31.1, P = .77); AOFAS (83 vs 91.2, P = .19); FFI (20.7% vs 9.5%, P = .22); and Karlsson-Peterson (78.9 vs 87.1, P = .23). All grafts (100%) were intact on MRI with a well-preserved integrity and no signs of new rupture. There were no major differences in range of motion and functional outcomes as measured by strength testing between the operative and nonoperative side. Conclusion: Reconstructions of TAT achieved good PROs, as well as functional and imaging results with a preserved graft integrity in all cases. There were no substantial differences between allograft and autograft reconstructions. Level of Evidence: Level IV, retrospective case series.
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- 2021
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9. Isometric points in lateral ankle ligament reconstruction: A three-dimensional kinematic study
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Sylvano Mania, Christoph Zindel, Stephan Wirth, Arnd Viehöfer, University of Zurich, and Mania, Sylvano
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2732 Orthopedics and Sports Medicine ,Orthopedics and Sports Medicine ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center - Abstract
To optimize the biomechanical outcomes in lateral ankle ligament reconstruction, avoid stiffness or residual laxity, aiming for an isometric reconstruction of the anterior lateral talofibular ligament (ATFL) and the calcaneofibular ligament (CFL) is mandatory. However, the localization of the optimal ligament insertion remains challenging to assess intraoperatively.Three-dimensional (3D) surface models from 10 healthy ankles were generated. 30 insertion points of the CFL were defined on the lateral side of the calcaneus each 10% of its total length in the dorsal-to-ventral and proximal-to-distal plane. 6 insertion points were defined at the ventral ridge of fibula from the malleolar tip and 5 insertions were defined along the lateral talar process. The ligament length variation of ATFL and CFL was assessed after a simulation of the flexion/extension around a simulated tibiotalar axis and inversion/eversion around a simulated subtalar axis in 36 different positions.The isometric point of CFL on the calcaneus is located at about 60% along the dorsal-to-ventral and between 60% and 70% along the proximal-to-distal plane. From maximal extension to flexion, these points present respectively a length variation of - 0.8 to - 1.1 mm (p = 0.46) and - 1.1 to - 0.8 mm (p = 0.56). A fibular insertion at 5 mm proximal to the malleolar tip present a length variation ranging from - 0.1-1 mm (p 0.001) for ATFL and from - 0.7-0.5 mm (p 0.001) for CFL. A talar insertion point of the ATFL located 5 mm proximal to the subtalar joint present the lowest variation, ranging from - 1.1-0.7 mm (p 0.001), however an insertion at 20- or 25-mm present isometry (+0.1 to +0.9 mm p = 0.1, and +0.4 to +0.4 mm p = 1 respectively) if the fibular insertion is located at 5 mm proximal to the malleolar tip.This study provides anatomical references which are reproducible in daily practice. These insertion points allow to achieve a stable reconstruction while maintaining a tension-free mobilization of the ankle.
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- 2022
10. The Role of Plantar Fascia Tightness in Hallux Limitus: A Biomechanical Analysis
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Roland S. Camenzind, Stephan H. Wirth, Magdalena Vich, Arnd F. Viehöfer, Norman Espinosa, University of Zurich, and Viehöfer, Arnd F
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musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,10017 Institute of Anatomy ,610 Medicine & health ,Fascial structure ,Tendons ,Weight-Bearing ,03 medical and health sciences ,Hallux rigidus ,2732 Orthopedics and Sports Medicine ,0302 clinical medicine ,Cadaver ,Humans ,Medicine ,Hallux Limitus ,Orthopedics and Sports Medicine ,Tibia ,Fibula ,Orthodontics ,business.industry ,Forefoot ,030206 dentistry ,musculoskeletal system ,medicine.disease ,Biomechanical Phenomena ,2746 Surgery ,Surgery ,body regions ,medicine.anatomical_structure ,Clamp ,Aponeurosis ,570 Life sciences ,biology ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Plantar fascia ,Stress, Mechanical ,030101 anatomy & morphology ,business - Abstract
Restriction of greater toe dorsiflexion without degeneration of the first metatarsophalangeal joint is defined as hallux limitus. We assume that in hallux limitus the limitation of greater toe dorsiflexion takes place in the terminal stance phase because of massive tightening of the calf and plantar structures. The current study investigated the role of a tight plantar fascial structure in impairing dorsiflexion of the greater toe. For the purpose of the study, 7 lower limbs from Thiel-fixated human cadavers were evaluated. To simulate double-limb standing stance, the tibia and fibula were mounted on a materials testing machine and constantly loaded with 350N. Additionally, the tendons of the specimens were loaded using a custom-made system. The plantar fascia was fixed to a clamp and tensioned using a threaded bar. Four different tensile forces were then applied to the plantar fascia (approximately 100, 200, 300, and 350 N) and the extension of the first toe was measured. The results show a significant positive correlation between the decrease in extension of the hallux and the tension applied to the plantar fascia reaching a maximum mean decrease of 4.2° (117% compared with the untightened situation) for an applied tension of 364N.
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- 2019
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11. Smoking Is Associated with Anterior Ankle Impingement After Isolated Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus
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Stephan H. Wirth, Fabio A. Casari, Florian B. Imhoff, Arnd F. Viehöfer, Silvan Beeler, Felix W A Waibel, Jakob Ackermann, University of Zurich, and Ackermann, Jakob
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Adult ,Male ,medicine.medical_specialty ,Intra-Articular Fractures ,Biomedical Engineering ,2204 Biomedical Engineering ,610 Medicine & health ,Physical Therapy, Sports Therapy and Rehabilitation ,Osteoarthritis ,Transplantation, Autologous ,Talus ,Young Adult ,medicine ,Humans ,Immunology and Allergy ,In patient ,3612 Physical Therapy, Sports Therapy and Rehabilitation ,Autografts ,Cartilage repair ,Clinical Research papers ,Retrospective Studies ,business.industry ,Smoking ,Anterior ankle impingement ,Middle Aged ,medicine.disease ,Surgery ,Autologous matrix-induced chondrogenesis ,medicine.anatomical_structure ,2723 Immunology and Allergy ,Female ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Cartilage lesion ,Ankle ,business ,Chondrogenesis - Abstract
Objective To determine potential predictive associations between patient-/lesion-specific factors, clinical outcome and anterior ankle impingement in patients that underwent isolated autologous matrix-induced chondrogenesis (AMIC) for an osteochondral lesion of the talus (OLT). Design Thirty-five patients with a mean age of 34.7 ± 15 years who underwent isolated cartilage repair with AMIC for OLTs were evaluated at a mean follow-up of 4.5 ± 1.9 years. Patients completed AOFAS (American Orthopaedic Foot and Ankle Society) scores at final follow-up, as well as Tegner scores at final follow-up and retrospectively for preinjury and presurgery time points. Pearson correlation and multivariate regression models were used to distinguish associations between patient-/lesion-specific factors, the need for subsequent surgery due to anterior ankle impingement and patient-reported outcomes. Results At final follow-up, AOFAS and Tegner scores averaged 92.6 ± 8.3 and 5.1 ± 1.8, respectively. Both body mass index (BMI) and duration of symptoms were independent predictors for postoperative AOFAS and Δ preinjury to postsurgery Tegner with positive smoking status showing a trend toward worse AOFAS scores, but this did not reach statistical significance ( P = 0.054). Nine patients (25.7%) required subsequent surgery due to anterior ankle impingement. Smoking was the only factor that showed significant correlation with postoperative anterior ankle impingement with an odds ratio of 10.61 when adjusted for BMI and duration of symptoms (95% CI, 1.04-108.57; P = 0.047). Conclusion In particular, patients with normal BMI and chronic symptoms benefit from AMIC for the treatment of OLTs. Conversely, smoking cessation should be considered before AMIC due to the increased risk of subsequent surgery and possibly worse clinical outcome seen in active smokers.
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- 2020
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12. How many screws are necessary for subtalar fusion? A retrospective study
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Stephan H. Wirth, Lukas Urbanschitz, Stefan Zimmermann, Yannick Fritz, Dominic Rigling, Arnd F. Viehöfer, University of Zurich, and Urbanschitz, Lukas
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,Arthrodesis ,medicine.medical_treatment ,Bone Screws ,610 Medicine & health ,Body Mass Index ,03 medical and health sciences ,2732 Orthopedics and Sports Medicine ,0302 clinical medicine ,Subtalar fusion ,Diabetes Mellitus ,medicine ,Retrospective analysis ,Humans ,Orthopedics and Sports Medicine ,In patient ,Prospective Studies ,Prospective cohort study ,Retrospective Studies ,Fixation (histology) ,030222 orthopedics ,business.industry ,Subtalar Joint ,Retrospective cohort study ,030229 sport sciences ,Middle Aged ,Surgery ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Female ,business ,Body mass index - Abstract
Background Biomechanical studies have shown a higher compressive force and higher torsional stiffness for fixation with three screws compared to two screws. However, clinical data to compare these fixation techniques is still lacking. Methods A retrospective analysis of 113 patients was performed, who underwent isolated subtalar fusion between January 2006 and April 2018. Results Revision arthrodesis was required in 8% (n = 6/36) for 3-screw-fixation and 38% (n = 35/77) for 2-screw-fixation. For 3-screw-fixation, non-union, was observed in 14% (n = 5/36) compared to 35% (n = 27/77) in 2-screw fixation. Non-union (p = .025) and revision arthrodesis (p = .034) were significantly more frequent in patients with 2 screws. A body mass index ≥30 kg/m2 (p = .04, OR = 2.6,95%CI:1.1–6.3), prior ankle-fusion (p = .017,OR = 4.4,95%CI:1.3–14.5) and diabetes mellitus (p = .04,OR = 4.9,95%CI:1.1–17.8) were associated with a higher rate of revision arthrodesis. Conclusions Our findings suggest that successful subtalar fusion is more reliably achieved with use of three screws. However, future prospective studies will be necessary to further specify this recommendation.
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- 2020
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13. Arthrodesen am oberen Sprunggelenk
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Florian B. Imhoff, Roland S. Camenzind, Arnd F. Viehöfer, and Stephan H. Wirth
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Gynecology ,030222 orthopedics ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,medicine ,Orthopedics and Sports Medicine ,030229 sport sciences ,business - Abstract
Die Versteifung des oberen Sprunggelenks (OSG-Arthrodese) ist eine seit Langem etablierte Therapieoption fur die hochgradige tibiotalare Arthrose mit guten klinischen Ergebnissen. Die genaue klinische Untersuchung und Abwagung von Komorbiditaten, Anforderungen und Patientenaussichten sind entscheidend fur die Indikationsstellung zur Arthrodese. Zudem gibt die radiologische Standardbildgebung und ggf. eine zusatzliche Schnittbildgebung die Richtung fur eine Entscheidung zur Arthrodese oder Prothese sowie fur das geplante operative Vorgehen vor. In diesem Beitrag werden verschiedene operative Strategien vorgestellt, von arthroskopisch-assistiert uber mini-open bis hin zu vorderen und seitlichen Zugangen mit entsprechenden Korrekturmoglichkeiten und Osteosyntheseverfahren.
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- 2020
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14. Plantar Fasciitis in Diabetic Foot Patients: Risk Factors, Pathophysiology, Diagnosis, and Management
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Gariani K, Waibel FWA, Viehöfer AF, and Uçkay I
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RC581-951 ,diagnosis ,Specialties of internal medicine ,epidemiology ,plantar fasciitis ,diabetic foot ,management - Abstract
Karim Gariani,1 Felix WA Waibel,2 Arnd F Viehöfer,2 Ilker Uçkay3 1Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland; 2Foot and Ankle Service, Department of Orthopedic Surgery, Balgrist University Hospital, Zurich, Switzerland; 3Unit for Clinical and Applied Research, Balgrist University Hospital, Zurich, SwitzerlandCorrespondence: Karim GarianiEndocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, SwitzerlandEmail Karim.gariani@hcuge.chAbstract: Plantar fasciitis (PF) is a common degenerative disorder and a frequent cause of heel pain, mostly affecting patients in their fourth and fifth decades. Diabetic patients are particularly at risk due to the presence of common risks and co-morbidities such as obesity or a sedentary lifestyle. The diagnosis of PF is mainly clinical. Imaging is not recommended for the initial approach. The initial management is conservative and should include physiotherapy, off-loading, stretching exercises, and nonsteroidal anti-inflammatory drugs. Glucocorticoid injections or surgery is an option at a later stage in recalcitrant cases. The overall management of PF does not differ between patients with diabetic foot problems and non-diabetic patients, although the details can differ. This narrative review summarizes the stateoftheart in terms of the risk factors, pathophysiology, diagnosis, assessment, and management of PF in diabetic patients.Keywords: plantar fasciitis, diabetic foot, management, epidemiology, diagnosis
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- 2020
15. Plantar Fasciitis in Diabetic Foot Patients: Risk Factors, Pathophysiology, Diagnosis, and Management
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Karim Gariani, Arnd F. Viehöfer, Ilker Uçkay, and Felix W A Waibel
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Pharmacology ,medicine.medical_specialty ,Heel ,Degenerative Disorder ,business.industry ,Plantar fasciitis ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,medicine.disease ,Diabetic foot ,Pathophysiology ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,Epidemiology ,Internal Medicine ,medicine ,medicine.symptom ,Stage (cooking) ,business ,Sedentary lifestyle - Abstract
Plantar fasciitis (PF) is a common degenerative disorder and a frequent cause of heel pain, mostly affecting patients in their fourth and fifth decades. Diabetic patients are particularly at risk due to the presence of common risks and co-morbidities such as obesity or a sedentary lifestyle. The diagnosis of PF is mainly clinical. Imaging is not recommended for the initial approach. The initial management is conservative and should include physiotherapy, off-loading, stretching exercises, and nonsteroidal anti-inflammatory drugs. Glucocorticoid injections or surgery is an option at a later stage in recalcitrant cases. The overall management of PF does not differ between patients with diabetic foot problems and non-diabetic patients, although the details can differ. This narrative review summarizes the state of the art in terms of the risk factors, pathophysiology, diagnosis, assessment, and management of PF in diabetic patients.
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- 2020
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16. Restoration of the patient-specific anatomy of the distal fibula based on a novel three-dimensional contralateral registration method
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Calek, Anna-Katharina, Hodel, Sandro, Hochreiter, Bettina, Viehöfer, Arnd, Fucentese, Sandro, Wirth, Stephan, Vlachopoulos, Lazaros, University of Zurich, and Calek, Anna-Katharina
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2732 Orthopedics and Sports Medicine ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Orthopedics and Sports Medicine - Abstract
Purpose Posttraumatic fibular malunion alters ankle joint biomechanics and may lead to pain, stiffness, and premature osteoarthritis. The accurate restoration is key for success of reconstructive surgeries. The aim of this study was to analyze the accuracy of a novel three-dimensional (3D) registration algorithm using different segments of the contralateral anatomy to restore the distal fibula. Methods Triangular 3D surface models were reconstructed from computed tomographic data of 96 paired lower legs. Four segments were defined: 25% tibia, 50% tibia, 75% fibula, and 75% fibula and tibia. A surface registration algorithm was used to superimpose the mirrored contralateral model on the original model. The accuracy of distal fibula restoration was measured. Results The median rotation error, 3D distance (Euclidean distance), and 3D angle (Euler’s angle) using the distal 25% tibia segment for the registration were 0.8° (− 1.7–4.8), 2.1 mm (1.4–2.9), and 2.9° (1.9–5.4), respectively. The restoration showed the highest errors using the 75% fibula segment (rotation error 3.2° (0.1–8.3); Euclidean distance 4.2 mm (3.1–5.8); Euler’s angle 5.8° (3.4–9.2)). The translation error did not differ significantly between segments. Conclusion 3D registration of the contralateral tibia and fibula reliably approximated the premorbid anatomy of the distal fibula. Registration of the 25% distal tibia, including distinct anatomical landmarks of the fibular notch and malleolar colliculi, restored the anatomy with increasing accuracy, minimizing both rotational and translational errors. This new method of evaluating malreductions could reduce morbidity in patients with ankle fractures. Level of evidence IV
- Published
- 2022
17. A Biomechanical Analysis of Peroneus Brevis Split Lesions, Repair, and Partial Resection
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Tudor Trache, Roland S. Camenzind, Elias Bachmann, Arnd Viehöfer, Lukas Jud, Stephan Wirth, Florian B. Imhoff, University of Zurich, and Imhoff, Florian B
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Rupture ,Tendons ,Leg ,2732 Orthopedics and Sports Medicine ,Tendon Injuries ,Humans ,Orthopedics and Sports Medicine ,Surgery ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Ankle Injuries ,Middle Aged ,2746 Surgery - Abstract
Background: Peroneus brevis tendon tears are associated with chronic ankle pain and instability following sprain injuries. The aim of this study is to elucidate the biomechanical changes induced by a peroneus brevis split and surgical treatment by tubularizing suture or partial resection. Methods: Nine human lower leg specimens were biomechanically tested. Preexisting tendon pathology was ruled out by magnetic resonance imaging and histology. Specimens were subjected to sequential testing of 4 conditions of the peroneus brevis tendon: (1) native, (2) longitudinal lesion, (3) tubularizing suture, and (4) 50% resection. The outcome parameters were the tendon stiffness (N/mm) and the length variation of the split portion at 5 N load. Results: The median specimen age at death was 55.8 years (range 50-64 years). The longitudinal tendon split led to an elongation by 1.21 ± 1.15 mm, which was significantly reduced by tubularizing suture to 0.24 ± 0.97 mm ( P = .021). Furthermore, 50% resection of the tendon elongated it by a mean 2.45 ± 1.9 mm ( P = .01) and significantly reduced its stiffness compared to the intact condition (4.7 ± 1.17 N/mm, P = .024) and sutured condition (4.76 ± 1.04 N/mm, P = .011). Conclusion: Longitudinal split and 50% resection of the peroneus brevis tendon led to elongation and loss of tendon stiffness. These properties were improved by tubularizing suture. The significance of these changes in the clinical setting needs further investigation. Clinical Relevance: Tubularizing suture of a peroneus brevis split can restore biomechanical properties to almost native condition, potentially aiding ankle stability in symptomatic cases. A split lesion and partial resection of the tendon showed reduced stiffness and increased elongation.
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- 2022
18. Lehrer, Dichter, Massenmörder
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Viehöfer, Erich
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920 Biografien, Genealogie, Insignien - Abstract
Am Freitag, dem 5. September 1913, meldete die »Ludwigsburger Zeitung«: »Schreckenstaten eines Geistesgestörten: Mühlhausen a. Enz, 5. Sept. Heute nach ½ 2Uhr hat der Schwiegersohn des hiesigen Adlerwirts, ein Hauptlehrer aus Degerloch, der offenbar wahnsinnig geworden war, den Ort an vier Stellen angezündet. Drei Scheunen brannten nieder. Als man ihn ergreifen wollte, schoss er mit einer Browning acht Leute nieder und verletzte etwa zehn. Hierauf flüchtete er in einen Stall, wo er einen Stier erschoss. Nachdem es gelungen war, ihn zu ergreifen, wurde er so zugerichtet, dass an seinem Aufkommen gezweifelt wird. Er hatte nicht weniger als 250 Patronen bei sich. Zum Löschen wurden in Vaihingen einquartierte Mannschaften vom Feldart.-Regt. 29 (Ludwigsburg) zu Hilfe gerufen.«
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- 2022
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19. Tibial Post-traumatic Deformity
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Arnd F. Viehöfer, Stephan H. Wirth, University of Zurich, Hitschfeld Wagner, Emilio, and Hitschfeld Wagner, Pablo
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610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center - Published
- 2022
20. Der Hohenasperg als Filialstrafanstalt des Ludwigsburger Zuchthauses (1883–1945)
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Viehöfer, Erich
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360 Soziale Probleme und Sozialdienste ,Verbände ,340 Recht - Abstract
Die Diskussion um die Nutzung des Hohenaspergs ist keine Angelegenheit der jüngsten Gegenwart. Vor fast 130 Jahren, am 5. Juni 1882, führte Justizminister Eduard von Faber (1822–1907) vor dem Abgeordnetenhaus in Stuttgart aus: »Bekanntlich ist für die derzeit auf Hohenasperg befindliche Garnison eine neue Kaserne in Heilbronn erbaut worden. Nach den Mitteilungen, die ich besitze, wird die Übersiedlung voraussichtlich im nächsten Frühjahr, keineswegs übrigens vor Georgii, stattfinden. […] Unter den verschiedenen möglichen Verwendungen für erhebliche Staatszwecke, welche nach dem Abzug der Garnison in Betracht kommen können, wird vielleicht auch mitinbegriffen sein die Verwendung des Aspergs oder eines Theiles desselben zu einer Filialstrafanstalt für Zuchthaussträflinge oder Landesgefängnissträflinge, was einigermaßen nahe gelegt ist durch die bedauerliche Überfüllung unserer sämtlichen Strafanstalten. Allein, meine Herren, in dieser Hinsicht ist sehr große Vorsicht geboten. Der Asperg ist, das wird sich nicht bestreiten lassen, für die Zwecke einer Strafanstalt sehr wenig geeignet. Ich erinnere nur an die große Schwierigkeit der Beschaffung des Trinkwassers, welches gegenwärtig täglich per Fuhre vom Thal zu Berg heraufbefördert werden muß. Und an die ständigen Kosten, welche hiemit verknüpft sind. Ich erinnere ferner an die Erschwerung und an die Hindernisse, welche einer Strafanstalt für ihren Gewerbebetrieb erwachsen, wenn die Strafanstalt auf einem isolierten Bergkegel liegt.« Trotz aller Bedenken fiel die Entscheidung zugunsten des Strafvollzugs. Am 3. Juni 1883 bewilligten die Standesherren den Nachtrag von 91 440 Mark zur »Errichtung einer Filialstrafanstalt des Zuchthauses in Ludwigsburg auf Hohenasperg« ohne Debatte.
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- 2022
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21. The Role of Magnetic Resonance Imaging in Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: Analyzing MOCART 1 and 2.0
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Christoph Germann, Lizzy Weigelt, Jakob Ackermann, Arnd F. Viehöfer, Stephan H. Wirth, Fabio A. Casari, University of Zurich, and Ackermann, Jakob
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Biomedical Engineering ,2204 Biomedical Engineering ,Physical Therapy, Sports Therapy and Rehabilitation ,610 Medicine & health ,Osteoarthritis ,Transplantation, Autologous ,Talus ,Cohort Studies ,medicine ,Immunology and Allergy ,Postoperative outcome ,Humans ,3612 Physical Therapy, Sports Therapy and Rehabilitation ,Cartilage repair ,Clinical Research papers ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Autologous matrix-induced chondrogenesis ,2723 Immunology and Allergy ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,business ,Nuclear medicine ,Chondrogenesis - Abstract
Objective To determine the role of magnetic resonance imaging (MRI) MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 1 and 2.0 scores in the assessment of postoperative outcome after autologous matrix-induced chondrogenesis (AMIC) for the treatment of osteochondral lesions of the talus (OLTs). It was hypothesized that preoperative patient factors or OLT morphology are associated with postoperative MOCART scores; yet postoperative clinical outcome is not. Study Design Cohort study; Level of evidence, 4. This study evaluated isolated AMIC that were implanted on the talus of 35 patients for the treatment of symptomatic OLT. Tegner and AOFAS (American Orthopaedic Foot and Ankle Society) scores were obtained at an average follow-up of 4.5 ± 1.8 years and postoperative MRI scored according to the MOCART 1 and 2.0. Results OLT size showed significant correlation with postoperative MRI scores (MOCART 1: P = 0.006; MOCART 2.0: P = 0.004). Bone grafting was significantly associated with a MOCART 1 subscale (signal intensity of repair tissue; P = 0.038). Age and defect size showed significant correlations with MOCART 2.0 subscales ( P < 0.05). Patients with shorter follow-up had a significantly higher MOCART 1 score and a trend toward better MOCART 2.0 scores than patients with longer follow-up (64.7 vs. 52.9 months, P = 0.02; 69.4 vs. 60.6 months, P = 0.058). No MOCART score was associated with postoperative patient-reported outcomes (n.s.). Conclusion Osteochondral lesion size is associated with postoperative MOCART scores in patients treated with AMIC for OLTs, with decreasing MOCART scores over time. Yet clinical outcome does not correlate with any MOCART score. Thus, MOCART assessment seems to have no significant role in the postoperative treatment of asymptomatic patients that underwent AMIC for OLTs.
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- 2021
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22. Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease
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Tejerina E. E., Pelosi P., Robba C., Penuelas O., Muriel A., Barrios D., Frutos-Vivar F., Raymondos K., Du B., Thille A. W., Rios F., Gonzalez M., Del-Sorbo L., Marin M. D. C., Valle Pinheiro B., Soares M. A., Nin N., Maggiore S. M., Bersten A., Amin P., Cakar N., Young Suh G., Abroug F., Jibaja M., Matamis D., Ali Zeggwagh A., Sutherasan Y., Anzueto A., Esteban A, Fernando Ríos, Damian Violi, Marisol Rodríguez-Goñi, Roger Lamoglie, Fernando Villarejo, Norberto Tiribelli, Santiago Ilutovich, Matías Brizuela, Mariana Monllau, Fernando Saldarini, Silvina Borello, Alberto Marino, Mauricio Vinzio, Karina Bonasegla, Julián Hernández, María Belén Yapur, María Eugenia González, Sebastián E Mare, Judith Sagardía, Marco Bezzi, Cecilia Pereyra, Julian Strati, Daniel Vargas, Claudia Diaz, Pablo Gómez, Marcelo Palavecino, Graciela Elizabeth, Aguilera García, M Eugenia, Luis Pablo Cardonnet, Lisandro Betttini, Hernán Nuñez, Lucas Vallejo, Fernando Fernández, Jorge Arroyo, Daniel Duarte, Gerardo Filippa, Cayetano Galetti, Hernan Nunia, Fernando Lambert, Elisa Estenssoro, Marina Busico, Javier Horacio Álvarez, Alejandro Raimondi, Gustavo Badariotti, Martín Lugaro, Fernando Lipovestky, Alan Javier Zazu, Hugo Capponcelli, Patricia Vogl, Cristina Orlandi, Alejandro Gómez, Gustavo Jannello, Alejandro Risso, Leticia Rapetti, Guillermo Chiappero, Juan Domingo Fernández, Rodrigo E Gómez-Paz, Marcos Juan Zec, Pascual Valdez, Jorgelina Guyon, Ariel Chena, Sergio Lasdica, Martin Deheza, Schimdt Alejandra, Francisco Criado, Norma Beatriz Márquez, Pablo Desmery, José Luis Scapellato, Gonzalo Javier Ríos, Cristian Casabella, Jasmin Board, Andrew Davies, Andrew Bersten, Elisha Matheson, Amy Waters, John Santamaria, Jennifer Holmes, Cartan Costello, Manoj K Saxena, John Myburgh, Ellen Kinkel, Forbes McGain, Claire Cattigan, Allison Bone, Ian Seppelt, Leonie Weisbrodt, Cheryl Cuzner, Christopher MacIsaac, Deborah Barge, Tania Caf, Cameron Knott, Graeme Duke, Imogen Mitchell, Helen Rodgers, Rachel Whyte, Elisha Fulton, Alistair Nichol, Hergen Buscher, Priya Nair, Claire Reynolds, Simon J G Hockley, Ian Moore, Katherine Davidson, David Milliss, Raju Pusapati, Helen Wong, Jason Fletcher, Julie Smith, Paul Goldrick, Dianne Stephens, Jane Thomas, Anders Aneman, Sutrisno Gunawan, Tom Cowlam, George Lukas, Rick McAllister, Minka Springham, Joanne Sutton, Jeff Presneill, Tony Sutherland, Dianne Hill, Howard Connor, Jenny Dennett, Tim Coles, Freddy Sandy, Sando Chavarria, Marcelo Choque, Ronald Pairumani, Juan Guerra, Marco Antônio Soares Reis, José Carlos Versiani, Eduardo Fonseca Sad, Maria Aparecida Braga, Dinalva Aparecida Gomes, Fernando Antônio Botoni, Maurício Meireles Góes, Frederico Costa Val Barros, Rogério de Castro Pereira, Hugo Urbano, Valéria de Carvalho Magela, Aline Camile Yehia, Bruno Bonaccorsi Fernandino, Marco Antônio Ribeiro Leão, Rovílson Lara, Rubens Altair Amaral de Pádua, Janine Dias Alves, Aloísio Marques do Nascimento, Bruno do Valle Pinheiro, Carlos Alberto Studart Gomes, Marcelo Alcântara Holanda, Frederico Rodrigues Anselmo, Niall Ferguson, Neill Adhikari, Robert Fowler, Cheromi Sittambalam, Mehar-Un-Nisa Raja, Nicole Marinoff, Lauralyn McIntryre, Shawna Reddie, Laura Jones, Irene Watpool, Jeffrey Singh, Madison Dennis, Andrea Matte, Marc Lipkus, Ryan Albert, Andrew Steel, Emily Stern, Michael Miletin, Antonio Raso, Robyn Klages, Jan Friedrich, Orla Smith, Laura Wilson, Deborah Cook, Mark Bailey, Sangeeta Mehta, Stephen Lapinsky, Hannah Mathers, Cheryl Ethier, Stephanie Lubchansky, Samer Haj-Bakri, Dietrich Henzler, Lisa Julien, Luis Soto-Román, Juan Carlos Maurelia, César Antonio Maquilon, Luis Soto-Germani, Bin Du, Yan Kang, Bo Wang, Fachun Zhou, Fang Xu, Haibo Qiu, Yi Yang, Qingyuan Zhan, Bing Sun, Zhenjie Hu, Bin Yu, Xi Zhu, Yu Bai, Gang Li, Yi Li, Geng Zhang, Jianbiao Meng, Xiaobo Huang, Hong Pu, Daxing Yu, Chuanyun Qian, Wei Zhang, Yongjie Yin, Debiao Song, Yunxuan Yue, Zhengxuan Lv, Chengmin Yu, Qunmei Yao, Xue Wang, Yuan Xu, Wei He, Mian Chen, Zhihua Hu, Dongpo Jiang, Jian Huang, Wei Yu, Juanxian Gu, Yangong Chao, Zhixiang Li, Zhicheng Zhang, Wanxia Li, Zhenyang He, Jianguo Li, Chang Liu, Tiehe Qin, Shouhong Wang, Feng Li, Jun Jin, Jianhong Fu, Hongyang Xu, Hongyuan Lin, Jianying Guo, Yalin Liu, Jinghua Wang, Maoqin Li, Jiaqiong Li, Lei Chen, Qing Song, Liang Pan, Xianyao Wan, Jiuzhi Zhang, Weihai Yao, Yuhong Guo, Pang Wing Yan, Kelly Choy, Kwan Ming Chit, Patricia Leung, Chau Chin Man, Marco González, Ricardo Buitrago, Marcela Granados, Guillermo Ortiz, Cesar Enciso, Mario Gómez, Bladimir Alejandro Gil, Juan Pablo Sedano, Luis Fernando Castro Castro, Carlo Alberto Acosta, Marco Gonzalez, Francisco Molina, Camilo Pizarro, Mario Villabon, Carmelo Dueñas, Carlos Andrés Díaz, Nelson Fonseca, Rubén Camargo, Juan David Uribe, Hans-Henrik Bülow, Simona Beniczky, Jens Brushoj, Mikkel Præst, Birgitte Viebaek, Sine Wichman, Anette Mortensen, Susanne Andi Iversen, Bo Broberg, Edgard Luna, Manuel Jibaja, Leonardo Pazmiño, Katty Trelles, Fabricio Picoita, Gustavo Paredes, Vanesa Ramírez, Guillermo Falconí, Cristian Cevallos, Boris Villamagua, Marco Escobar, Freddy Sánchez, Miguel Llano, Miguel Lazcano, Ramiro Puetate, José Miguel Guerrero, Mijail Játiva, Myriam Montalvo, Franklin Villegas, Luis González Zambrano, Ronnie Mantilla, Gina Quinde, Andrea Gimenez, Luis Gonzalez Mosquera, Henry Caballero, María Fernanda García, Marcelo Ochoa, Soraya Puertas, Jackeline Coello, Mario Acosta, Medhat Soliman, Arnaud W Thille, Achille Kouatchet, Alain Mercat, Laurent Brochard, François Collet, Guillaume Marcotte, Pascal Beuret, Jean-Christophe M Richard, Gaëtan Bedunaeu, Pierre-Gildas Guitard, Fabien Soulis, Frédéric Bellec, Philippe Berger, Dorothée Carpentier, Benoit Veber, Salem Ould Zein, Géraldine Dessertaine, C Canevet, Fabien Grelon, Konstantinos Raymondos, Rolf Dembinski, Rolf Rossaint, Steffen Weber-Carstens, Christian Putensen, Maximillian Ragaller, Michael Quintel, Winfried Schubert, Thomas Bein, Heinrich Paulus, Walter Brandt, Lutz Pfeiffer, Silke Frenzel, Thoralf Kerner, P Kruska, Leila Eckholt, Joachim Hartung, Harald Fritz, Monika Holler, Johannes Busch, Andreas Viehöfer, Jens Buettner, Jörn Schlechtweg, Achim Lunkeit, Roland Schneider, Maria Wussow, Nils Marquardt, Christian Frenkel, Falk Hildebrandt, Tumbass Volker, Thomas Lipp, Cezar Mihailescu, Thomas Moellhoff, Thomas Steinke, Oliver Franke, Marcus Ruecker, Markus Schappacher, Steffen Appel, Heinz Kerger, Andreas Schwartz, Jan Dittmann, Jörg Haberkorn, Wolfgang Baier, Walter Seyde, Dimitros Matamis, Eleni Antoniadou, Pertsas Evangelos, Maria Giannakou, Zoltan Szentkereszty, Zsolt Molnar, Pravin Amin, Farhad N Kapadia, Nagarajan Ramakrishnan, Deepak Govil, Anitha Shenoy, Umesh G, Samir Sahu, Sheila Nainan Myatra, Subhash Kumar Todi, Sanjay Dhanuka, Mayur Patel, P Samaddar, Dhruva Chaudhry, Vivek Joshi, Srinivas Samavedam, Ankur Devendra Bhavsar, Prachee Sathe, Sujoy Mukherjee, Salvatore Maurizio Maggiore, Francesco Idone, Federica Antonicelli, Paolo Navalesi, Rosanna Vaschetto, Arianna Boggero, Rosalba Tufano, Michele Iannuzzi, Edoardo De Robertis, Romano Tetamo, Andrea Neville Cracchiolo, Antonio Braschi, Francesco Mojoli, Ilaria Curro', Mirko Belliato, Chiara Verga, Marta Ferrari, Erika Mannelli, Valerio Mangani, Giorgio Tulli, Francesca Frigieri, Armando Pedulla', Monica Rocco, Giorgia Citterio, Di Russo, Gaetano Perchiazzi, Loredana Pitagora, Antonio Pesenti, Michela Bombino, Davide Chiumello, Federica Tallarini, Serena Azzari, Antonina Pigna, Ivano Aprile, Marco Adversi, Antonio Corcione, Marianna Esposito, Annunziata Mattei, Vito Marco Ranieri, Rosario Urbino, Ilaria Maria Mastromauro, Antonino Giarratano, Maurizio Raineri Santi, Ambrogio Sansone, Younsuck Koh, Moo Suk Park, Je Hyeong Kim, Kyung Chan Kim, Hye Sook Choi, Yun Seong Kim, Jin Hwa Lee, Myung-Goo Lee, Won-Yeon Lee, Jin Young An, Gee Young Suh, Ki-Suck Jung, Asisclo J Villagómez Ortiz, César Cruz Lozano, Zalatiel Maycotte Luna, José Francisco López Baca, José Elizalde, Guillermo Cueto Robledo, Mario Alonso Treviño Salinas, Ricardo Martinez Zubieta, Claudia Olvera-Guzman, Marco Montes De Oca, Silvio A Ñamendys-Silva, José Salvador Martínez Cano, Jose Angel Baltazar Torres, Gustavo Morales Muñoz, Antonio Villa Delgado, Javier Ladape Martinez, Amine Ali Zeggwagh, Tarek Dendane, Abderrahim Azzouzi, Ahmed Sbihi, Wajdi Maazouzi, Mourad Amor, Charki Haimeur, Michael A Kuiper, Matty Koopmans, Uli Strauch, Dennis Bergmans, Serge Heines, Sylvia den Boer, Bas M Kors, Peter van der Voort, Paul J Dennesen, Bert Beishuizen, Ingrid van den Hul, Erna Alberts, Harry P P M Gelissen, Eduard Bootsma, Auke Reidinga, Kim Heus, Diane Mackle, Paul Young, Rachael Parke, Eileen Gilder, Jodi Brown, Lynette Newby, Catherine Simmonds, Jan Mehrtens, Seton Henderson, Tony Williams, Judi Tai, Chantal Hogan, Mary La Pine, John Durning, Sheree Gare, Troy Browne, Shirley Nelson, Jennifer Goodson, Julio Osorio, Chabu Coronado, Rollin Roldán Mori, Rosa Luz López Martínez, Adam Mikstacki, Barbara Tamowicz, Rui Moreno, Eduardo Almeida, Joana Silvestre, Heloisa Castro, Irene Aragão, Susana Alves Ferreira, Nelson Barros, Filomena Faria, Carlos André Correia Casado, Fausto Fialho Moura, Paulo Marcal, Ricardo Matos, Edward Nicolayenko, Mikhail Kirov, Andrey Yaroshetskiy, Andrei Piontek, Valery Subbotin, Yaseen Arabi, Olivia Dulfo, Chafrina Marie Olay, Edgardo E Tabhan, Nicolas Nin, Alfonso Muñoz, César Aragón, Ana Villagrá, Ainhoa Rosselló, Joan Maria Raurich, María Garitacelaya, Miguel Ángel González-Gallego, Francisco Ortuño, Miguel Fernández-Vivas, David Freire, Francisco Guerrero, Francisco Manzano, Juan Carlos, Alfredo Padrón, Pedro Rosa, Rafael Morales, Liliana Caipe, Maurizio Bottiroli, José María Nicolás, Marta Ugalde, Javier Ruiz, Lucia Capilla, Guillermo Muñiz, Jesús Sánchez-Ruiz, Javier Cebrián, Begoña Balerdi, Elena Parreño, Alvaro van Bommel, César Pérez-Calvo, Irene Dot, Javier Blanco, Raquel Manzanedo, José J Blanco, Daniel Fontaneda, Raúl González, Javier Díaz Domínguez, Alfonso Moreno, Antonio Reyes, Ian Carrasco, Itziar Mintegui, Rosa Sebastián, Javier García-Alonso, Carolina Lorencio, Josep Maria Sirvent, Patricia Jimeno, Miguel León, Pedro Galdos, Nuria Alonso, Julia López-Díaz, María Victoria de la Torre, Jorge Vidal Hernández, Nicolás Zamboschi, Francisco Lucena, Gemma Rialp, Raquel Montoiro, Victoria Goñi, María Ángeles Pena, Antonio Maestre, Marc Fabra, Jacinto Baena, Eva Benveniste, Susana Temprano, Jesús Sánchez, Carmen Campos, Sara Cabañes, María Elena Pérez-Losada, José Claudio Leo, Enrique Piacentini, María Del Carmen de la Torre, Laura Álvarez-Montero, Fernando Sánchez, Antonio Viñuales, Bernabé Álvarez, Javier Castañeda, Ángela Alonso, María Isabel Ruiz, Pedro Jesús Domínguez, Marcos Delgado, Eugenio Palazón, Antonio García-Jiménez, Rosa Álvaro, Clara Laplaza Eva Regidor, Enrique Maraví, José María Quiroga, Amalia Martínez de la Gandara, Cecilia Carbayo, María Luisa Navarrete, Manuel Valledor, Raquel Yano, José María Gutiérrez, Javier González-Robledo, Amparo Ferrandiz, Alberto Belenguer, Lidón Mateu, Laura Sayagues, María José Tolón, Nieves Franco, Elena Gallego, Félix Lacoma, Patricia Albert, Vicente Arraez, Mar Gobernado, Susana Moradillo, Carolina Gímenez-Esparza, Teresa Sánchez de Dios, Carlos Marian Crespo, Cecilia Hermosa, Federico Gordo, Genis Carrasco, María Ángeles Alonso, Alejandro Algora, Raúl de Pablo, Sofía García, Ana Carolina Caballero, José María Montón, Teresa Mut, Eva Manteiga, Alejandro de la Serna, Ana Esther Trujillo, Rafael Blancas, Inmaculada Vallverdú, José Manuel Serrano, Miquel Ferrer, Juan Diego Jiménez, Carlos Gallego, Dolores Vila, Luis Marina, Valentín Parra, Juan Ramón Cortés, Chen Chin-Ming, Ai-Chin Cheng, Fekri Abroug, Besbes Mohamed, Imed Chouchene, Mounir Bouaziz, Stambouli Neji, Islem Ouanes, Ayed Samia, Nahit Cakar, Ismail Kati, Ali Aydım Altunkan, Remzi Iscimen, Zafer Dogan, Bilge Çetin, Tayfun Adanir, Sabriye Guvenc, Unase Büyükkoçak, Antonio Anzueto, Ashley Ellis, Gary Kinasewitz, Allan Walkey, Phil Alkana, Gregory A Schmidt, Susan Gillen, Kathleen Lilli, Jennifer Twombley, Denice Wells, Larry Welder, Alejandro Arroliga, Alfredo Vasquez-Sandoval, Vincent John Scott, Craig Cernosek, Christopher Spradley, Dimple Tejwani, Sindhaghatta Venkatram, Gilda Diaz-Fuentes, Amber Monson, Anthony Saleh, Madhav Gudi, George Liziamma, Mohamed A Saad, Crissie De Spirito, Bryan Beatty, Samir Vermani, Crissie Despirito, Zaza Cohen, Amee Patrawalla, Samir Abdelhadi, Rupesh Vakil, Steven Y Chang, Brian Sherman, Rosanna Del Giudice, John Oropell, Timothy D Girard, Cayce Strength, Joyce Okahashi, Leanne Boehm, Matthew Kirchner, Erwin J Oei, Sebastian Circo, Nelson Medina, Mohammed Al-Jagbeer, V J Cardenas Jr, Smyth Smith, Shelby Sutton, Marcela Canola-Mazo, Tim Houlihan, Yogeet Kaur, Travis Parry, Craig A Piquette, Kerry Canady, Rahul Nanchal, Dana K Soetaert, Maria Del Mar Torres-Perez, Carlos Robles-Arias, William Rodriguez-Cintron, Mark Tidswell, Jennifer Germain, Lori-Ann Kozikowski, Erin Braden, Geneva Tatem, Javier Hurtado, Alberto Deicas, Daniel Weiss, Marta Beron, Román Garrido, Cristina Santos, Mario Cancela, Raúl Lombardi, Pedro Alzugaray, Jorge Gerez, Silvia Mareque, Graciela Franca, Oscar Cluzet, Edgardo Nuñez, Julio Pontet, Sergio Cáceres, Elias Caragna, Alberto Soler, Frank Torres, Gastón Pittini, Gabriel D Empaire, Stevens Salva, Fernando Pérez, Clara Pacheco, Zoraida Parra, Ingrid Von der Osten, Luis Williams, José Salinas, Do Danh Quynh, Pham Thi Van Anh, Nguyen Huu Hoang, Nghuyen Ba Tuan, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Arts Assistenten IC (9), Intensive Care, MUMC+: MA Medische Staf IC (9), Tejerina E.E., Pelosi P., Robba C., Penuelas O., Muriel A., Barrios D., Frutos-Vivar F., Raymondos K., Du B., Thille A.W., Rios F., Gonzalez M., Del-Sorbo L., Marin M.D.C., Valle Pinheiro B., Soares M.A., Nin N., Maggiore S.M., Bersten A., Amin P., Cakar N., Young Suh G., Abroug F., Jibaja M., Matamis D., Ali Zeggwagh A., Sutherasan Y., Anzueto A., Esteban A, and Fernando Ríos, Damian Violi, Marisol Rodríguez-Goñi, Roger Lamoglie, Fernando Villarejo, Norberto Tiribelli, Santiago Ilutovich, Matías Brizuela, Mariana Monllau, Fernando Saldarini, Silvina Borello, Alberto Marino, Norberto Tiribelli, Mauricio Vinzio, Karina Bonasegla, Julián Hernández, María Belén Yapur, María Eugenia González, Sebastián E Mare, Judith Sagardía, Marco Bezzi, Cecilia Pereyra, Julian Strati, Daniel Vargas, Claudia Diaz, Pablo Gómez, Marcelo Palavecino, Graciela Elizabeth, Aguilera García, M Eugenia, Luis Pablo Cardonnet, Lisandro Betttini, Hernán Nuñez, Lucas Vallejo, Fernando Fernández, Jorge Arroyo, Daniel Duarte, Gerardo Filippa, Cayetano Galetti, Hernan Nunia, Fernando Lambert, Elisa Estenssoro, Marina Busico, Fernando Villarejo, Javier Horacio Álvarez, Alejandro Raimondi, Gustavo Badariotti, Martín Lugaro, Fernando Lipovestky, Alan Javier Zazu, Hugo Capponcelli, Patricia Vogl, Cristina Orlandi, Alejandro Gómez, Gustavo Jannello, Alejandro Risso, Leticia Rapetti, Guillermo Chiappero, Juan Domingo Fernández, Rodrigo E Gómez-Paz, Marcos Juan Zec, Pascual Valdez, Jorgelina Guyon, Ariel Chena, Sergio Lasdica, Martin Deheza, Schimdt Alejandra, Francisco Criado, Norma Beatriz Márquez, Pablo Desmery, José Luis Scapellato, Gonzalo Javier Ríos, Cristian Casabella, Jasmin Board, Andrew Davies, Andrew Bersten, Elisha Matheson, Amy Waters, John Santamaria, Jennifer Holmes, Cartan Costello, Manoj K Saxena, John Myburgh, Ellen Kinkel, Forbes McGain, Claire Cattigan, Allison Bone, Ian Seppelt, Leonie Weisbrodt, Cheryl Cuzner, Christopher MacIsaac, Deborah Barge, Tania Caf, Cameron Knott, Graeme Duke, Imogen Mitchell, Helen Rodgers, Rachel Whyte, Elisha Fulton, Jasmin Board, Andrew Davies, Alistair Nichol, Hergen Buscher, Priya Nair, Claire Reynolds, Simon J G Hockley, Ian Moore, Katherine Davidson, David Milliss, Raju Pusapati, Helen Wong, Jason Fletcher, Julie Smith, Paul Goldrick, Dianne Stephens, Jane Thomas, Anders Aneman, Sutrisno Gunawan, Tom Cowlam, George Lukas, Rick McAllister, Minka Springham, Joanne Sutton, Jeff Presneill, Tony Sutherland, Dianne Hill, Howard Connor, Jenny Dennett, Tim Coles, Freddy Sandy, Sando Chavarria, Marcelo Choque, Ronald Pairumani, Juan Guerra, Marco Antônio Soares Reis, José Carlos Versiani, Eduardo Fonseca Sad, Maria Aparecida Braga, Dinalva Aparecida Gomes, Fernando Antônio Botoni, Maurício Meireles Góes, Frederico Costa Val Barros, Rogério de Castro Pereira, Hugo Urbano, Valéria de Carvalho Magela, Aline Camile Yehia, Bruno Bonaccorsi Fernandino, Marco Antônio Ribeiro Leão, Rovílson Lara, Rovílson Lara, Rubens Altair Amaral de Pádua, Janine Dias Alves, Aloísio Marques do Nascimento, Bruno do Valle Pinheiro, Carlos Alberto Studart Gomes, Marcelo Alcântara Holanda, Frederico Rodrigues Anselmo, Niall Ferguson, Neill Adhikari, Robert Fowler, Cheromi Sittambalam, Mehar-Un-Nisa Raja, Nicole Marinoff, Lauralyn McIntryre, Shawna Reddie, Laura Jones, Irene Watpool, Jeffrey Singh, Madison Dennis, Andrea Matte, Marc Lipkus, Ryan Albert, Andrew Steel, Emily Stern, Michael Miletin, Antonio Raso, Robyn Klages, Jan Friedrich, Orla Smith, Laura Wilson, Deborah Cook, Mark Bailey, Sangeeta Mehta, Stephen Lapinsky, Hannah Mathers, Cheryl Ethier, Stephanie Lubchansky, Samer Haj-Bakri, Dietrich Henzler, Lisa Julien, Luis Soto-Román, Juan Carlos Maurelia, César Antonio Maquilon, Luis Soto-Germani, Bin Du, Yan Kang, Bo Wang, Fachun Zhou, Fang Xu, Haibo Qiu, Yi Yang, Qingyuan Zhan, Bing Sun, Zhenjie Hu, Bin Yu, Xi Zhu, Yu Bai, Gang Li, Yi Li, Geng Zhang, Jianbiao Meng, Xiaobo Huang, Hong Pu, Bin Du, Daxing Yu, Chuanyun Qian, Wei Zhang, Yongjie Yin, Debiao Song, Yunxuan Yue, Zhengxuan Lv, Chengmin Yu, Qunmei Yao, Xue Wang, Yuan Xu, Wei He, Mian Chen, Zhihua Hu, Dongpo Jiang, Jian Huang, Wei Yu, Juanxian Gu, Yangong Chao, Zhixiang Li, Zhicheng Zhang, Wanxia Li, Zhenyang He, Jianguo Li, Chang Liu, Tiehe Qin, Shouhong Wang, Feng Li, Jun Jin, Jianhong Fu, Hongyang Xu, Hongyuan Lin, Jianying Guo, Yalin Liu, Jinghua Wang, Maoqin Li, Jiaqiong Li, Lei Chen, Qing Song, Liang Pan, Xianyao Wan, Jiuzhi Zhang, Weihai Yao, Yuhong Guo, Pang Wing Yan, Kelly Choy, Kwan Ming Chit, Patricia Leung, Chau Chin Man, Marco González, Ricardo Buitrago, Marcela Granados, Guillermo Ortiz, Cesar Enciso, Mario Gómez, Bladimir Alejandro Gil, Juan Pablo Sedano, Luis Fernando Castro Castro, Carlo Alberto Acosta, Marco Gonzalez, Francisco Molina, Camilo Pizarro, Mario Villabon, Carmelo Dueñas, Carlos Andrés Díaz, Nelson Fonseca, Rubén Camargo, Juan David Uribe, Hans-Henrik Bülow, Simona Beniczky, Jens Brushoj, Mikkel Præst, Birgitte Viebaek, Sine Wichman, Anette Mortensen, Susanne Andi Iversen, Bo Broberg, Edgard Luna, Manuel Jibaja, Leonardo Pazmiño, Katty Trelles, Fabricio Picoita, Gustavo Paredes, Vanesa Ramírez, Guillermo Falconí, Cristian Cevallos, Boris Villamagua, Marco Escobar, Freddy Sánchez, Miguel Llano, Miguel Lazcano, Ramiro Puetate, José Miguel Guerrero, Mijail Játiva, Myriam Montalvo, Franklin Villegas, Luis González Zambrano, Ronnie Mantilla, Gina Quinde, Andrea Gimenez, Luis Gonzalez Mosquera, Henry Caballero, María Fernanda García, Marcelo Ochoa, Soraya Puertas, Jackeline Coello, Mario Acosta, Medhat Soliman, Arnaud W Thille, Achille Kouatchet, Alain Mercat, Laurent Brochard, François Collet, Guillaume Marcotte, Pascal Beuret, Jean-Christophe M Richard, Gaëtan Bedunaeu, Pierre-Gildas Guitard, Fabien Soulis, Frédéric Bellec, Philippe Berger, Dorothée Carpentier, Benoit Veber, Salem Ould Zein, Géraldine Dessertaine, C Canevet, Fabien Grelon, Konstantinos Raymondos, Rolf Dembinski, Rolf Rossaint, Steffen Weber-Carstens, Christian Putensen, Maximillian Ragaller, Michael Quintel, Winfried Schubert, Thomas Bein, Heinrich Paulus, Walter Brandt, Lutz Pfeiffer, Silke Frenzel, Thoralf Kerner, P Kruska, Leila Eckholt, Joachim Hartung, Harald Fritz, Monika Holler, Johannes Busch, Andreas Viehöfer, Jens Buettner, Jörn Schlechtweg, Achim Lunkeit, Roland Schneider, Maria Wussow, Nils Marquardt, Christian Frenkel, Falk Hildebrandt, Tumbass Volker, Thomas Lipp, Cezar Mihailescu, Thomas Moellhoff, Thomas Steinke, Oliver Franke, Marcus Ruecker, Markus Schappacher, Steffen Appel, Heinz Kerger, Andreas Schwartz, Jan Dittmann, Jörg Haberkorn, Wolfgang Baier, Walter Seyde, Dimitros Matamis, Eleni Antoniadou, Pertsas Evangelos, Maria Giannakou, Zoltan Szentkereszty, Zsolt Molnar, Pravin Amin, Farhad N Kapadia, Nagarajan Ramakrishnan, Deepak Govil, Anitha Shenoy, Umesh G, Samir Sahu, Sheila Nainan Myatra, Subhash Kumar Todi, Sanjay Dhanuka, Mayur Patel, P Samaddar, Dhruva Chaudhry, Vivek Joshi, Srinivas Samavedam, Ankur Devendra Bhavsar, Prachee Sathe, Sujoy Mukherjee, Salvatore Maurizio Maggiore, Francesco Idone, Federica Antonicelli, Paolo Navalesi, Rosanna Vaschetto, Arianna Boggero, Rosalba Tufano, Michele Iannuzzi, Edoardo De Robertis, Romano Tetamo, Andrea Neville Cracchiolo, Antonio Braschi, Francesco Mojoli, Ilaria Curro', Mirko Belliato, Chiara Verga, Marta Ferrari, Erika Mannelli, Valerio Mangani, Giorgio Tulli, Francesca Frigieri, Armando Pedulla', Monica Rocco, Giorgia Citterio, Di Russo, Gaetano Perchiazzi, Loredana Pitagora, Antonio Pesenti, Michela Bombino, Davide Chiumello, Federica Tallarini, Serena Azzari, Antonina Pigna, Ivano Aprile, Marco Adversi, Antonio Corcione, Marianna Esposito, Annunziata Mattei, Vito Marco Ranieri, Rosario Urbino, Ilaria Maria Mastromauro, Antonino Giarratano, Maurizio Raineri Santi, Ambrogio Sansone, Younsuck Koh, Moo Suk Park, Je Hyeong Kim, Kyung Chan Kim, Hye Sook Choi, Yun Seong Kim, Jin Hwa Lee, Myung-Goo Lee, Won-Yeon Lee, Jin Young An, Gee Young Suh, Ki-Suck Jung, Asisclo J Villagómez Ortiz, César Cruz Lozano, Zalatiel Maycotte Luna, José Francisco López Baca, José Elizalde, Guillermo Cueto Robledo, Mario Alonso Treviño Salinas, Ricardo Martinez Zubieta, Claudia Olvera-Guzman, Marco Montes De Oca, Silvio A Ñamendys-Silva, José Salvador Martínez Cano, Jose Angel Baltazar Torres, Gustavo Morales Muñoz, Antonio Villa Delgado, Javier Ladape Martinez, Amine Ali Zeggwagh, Tarek Dendane, Abderrahim Azzouzi, Ahmed Sbihi, Wajdi Maazouzi, Mourad Amor, Charki Haimeur, Michael A Kuiper, Matty Koopmans, Uli Strauch, Dennis Bergmans, Serge Heines, Sylvia den Boer, Bas M Kors, Peter van der Voort, Paul J Dennesen, Bert Beishuizen, Ingrid van den Hul, Erna Alberts, Harry P P M Gelissen, Eduard Bootsma, Auke Reidinga, Jasmin Board, Andrew Davies, Kim Heus, Diane Mackle, Paul Young, Rachael Parke, Eileen Gilder, Jodi Brown, Lynette Newby, Catherine Simmonds, Jan Mehrtens, Seton Henderson, Tony Williams, Judi Tai, Chantal Hogan, Mary La Pine, John Durning, Sheree Gare, Troy Browne, Shirley Nelson, Jennifer Goodson, Julio Osorio, Chabu Coronado, Rollin Roldán Mori, Rosa Luz López Martínez, Adam Mikstacki, Barbara Tamowicz, Rui Moreno, Eduardo Almeida, Joana Silvestre, Heloisa Castro, Irene Aragão, Susana Alves Ferreira, Nelson Barros, Filomena Faria, Carlos André Correia Casado, Fausto Fialho Moura, Paulo Marcal, Ricardo Matos, Edward Nicolayenko, Mikhail Kirov, Andrey Yaroshetskiy, Andrei Piontek, Valery Subbotin, Yaseen Arabi, Olivia Dulfo, Chafrina Marie Olay, Edgardo E Tabhan, Nicolas Nin, Alfonso Muñoz, César Aragón, Ana Villagrá, Ainhoa Rosselló, Joan Maria Raurich, María Garitacelaya, Miguel Ángel González-Gallego, Francisco Ortuño, Miguel Fernández-Vivas, David Freire, Francisco Guerrero, Francisco Manzano, Juan Carlos, Alfredo Padrón, Pedro Rosa, Rafael Morales, Liliana Caipe, Maurizio Bottiroli, José María Nicolás, Marta Ugalde, Javier Ruiz, Lucia Capilla, Guillermo Muñiz, Jesús Sánchez-Ruiz, Javier Cebrián, Begoña Balerdi, Elena Parreño, Alvaro van Bommel, César Pérez-Calvo, Irene Dot, Javier Blanco, Raquel Manzanedo, José J Blanco, Daniel Fontaneda, Raúl González, Javier Díaz Domínguez, Alfonso Moreno, Antonio Reyes, Ian Carrasco, Itziar Mintegui, Rosa Sebastián, Javier García-Alonso, Carolina Lorencio, Josep Maria Sirvent, Patricia Jimeno, Miguel León, Pedro Galdos, Nuria Alonso, Julia López-Díaz, María Victoria de la Torre, Jorge Vidal Hernández, Nicolás Zamboschi, Francisco Lucena, Gemma Rialp, Raquel Montoiro, Victoria Goñi, María Ángeles Pena, Antonio Maestre, Marc Fabra, Jacinto Baena, Eva Benveniste, Susana Temprano, Jesús Sánchez, Carmen Campos, Sara Cabañes, María Elena Pérez-Losada, José Claudio Leo, Enrique Piacentini, María Del Carmen de la Torre, Laura Álvarez-Montero, Fernando Sánchez, Antonio Viñuales, Bernabé Álvarez, Javier Castañeda, Ángela Alonso, María Isabel Ruiz, Pedro Jesús Domínguez, Marcos Delgado, Eugenio Palazón, Antonio García-Jiménez, Rosa Álvaro, Clara Laplaza Eva Regidor, Enrique Maraví, José María Quiroga, Amalia Martínez de la Gandara, Cecilia Carbayo, María Luisa Navarrete, Manuel Valledor, Raquel Yano, José María Gutiérrez, Javier González-Robledo, Amparo Ferrandiz, Alberto Belenguer, Lidón Mateu, Laura Sayagues, María José Tolón, Nieves Franco, Elena Gallego, Félix Lacoma, Patricia Albert, Vicente Arraez, Mar Gobernado, Susana Moradillo, Carolina Gímenez-Esparza, Teresa Sánchez de Dios, Carlos Marian Crespo, Cecilia Hermosa, Federico Gordo, Genis Carrasco, María Ángeles Alonso, Alejandro Algora, Raúl de Pablo, Sofía García, Ana Carolina Caballero, José María Montón, Teresa Mut, Eva Manteiga, Alejandro de la Serna, Ana Esther Trujillo, Rafael Blancas, Inmaculada Vallverdú, José Manuel Serrano, Miquel Ferrer, Juan Diego Jiménez, Carlos Gallego, Dolores Vila, Luis Marina, Valentín Parra, Juan Ramón Cortés, Chen Chin-Ming, Ai-Chin Cheng, Fekri Abroug, Besbes Mohamed, Imed Chouchene, Mounir Bouaziz, Stambouli Neji, Islem Ouanes, Ayed Samia, Nahit Cakar, Ismail Kati, Ali Aydım Altunkan, Remzi Iscimen, Zafer Dogan, Bilge Çetin, Tayfun Adanir, Sabriye Guvenc, Unase Büyükkoçak, Antonio Anzueto, Ashley Ellis, Gary Kinasewitz, Allan Walkey, Phil Alkana, Gregory A Schmidt, Susan Gillen, Kathleen Lilli, Jennifer Twombley, Denice Wells, Larry Welder, Alejandro Arroliga, Alfredo Vasquez-Sandoval, Vincent John Scott, Craig Cernosek, Christopher Spradley, Dimple Tejwani, Sindhaghatta Venkatram, Gilda Diaz-Fuentes, Amber Monson, Anthony Saleh, Madhav Gudi, George Liziamma, Mohamed A Saad, Crissie De Spirito, Bryan Beatty, Samir Vermani, Crissie Despirito, Zaza Cohen, Amee Patrawalla, Samir Abdelhadi, Rupesh Vakil, Steven Y Chang, Brian Sherman, Rosanna Del Giudice, John Oropell, Timothy D Girard, Cayce Strength, Joyce Okahashi, Leanne Boehm, Matthew Kirchner, Ashley Ellis, Gary Kinasewitz, Erwin J Oei, Sebastian Circo, Nelson Medina, Mohammed Al-Jagbeer, V J Cardenas Jr, Smyth Smith, Shelby Sutton, Marcela Canola-Mazo, Tim Houlihan, Yogeet Kaur, Travis Parry, Craig A Piquette, Kerry Canady, Rahul Nanchal, Dana K Soetaert, Maria Del Mar Torres-Perez, Carlos Robles-Arias, William Rodriguez-Cintron, Mark Tidswell, Jennifer Germain, Lori-Ann Kozikowski, Erin Braden, Geneva Tatem, Javier Hurtado, Alberto Deicas, Daniel Weiss, Marta Beron, Román Garrido, Cristina Santos, Mario Cancela, Raúl Lombardi, Pedro Alzugaray, Jorge Gerez, Silvia Mareque, Graciela Franca, Oscar Cluzet, Edgardo Nuñez, Julio Pontet, Sergio Cáceres, Elias Caragna, Alberto Soler, Frank Torres, Gastón Pittini, Gabriel D Empaire, Stevens Salva, Fernando Pérez, Clara Pacheco, Zoraida Parra, Ingrid Von der Osten, Luis Williams, José Salinas, Do Danh Quynh, Pham Thi Van Anh, Nguyen Huu Hoang, Nghuyen Ba Tuan
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Male ,medicine.medical_treatment ,pulmonary complications ,RESPIRATORY-DISTRESS-SYNDROME ,Critical Care and Intensive Care Medicine ,CASE-FATALITY ,0302 clinical medicine ,Risk Factors ,Brain Injuries, Traumatic ,Multicenter Studies as Topic ,Hospital Mortality ,Prospective Studies ,Simplified Acute Physiology Score ,Stroke ,POPULATION ,Age Factors ,ANEURYSMAL SUBARACHNOID HEMORRHAGE ,Middle Aged ,Hemorrhagic Stroke ,Intensive Care Units ,Observational Studies as Topic ,Anesthesia ,Breathing ,Female ,medicine.symptom ,Ventilator Weaning ,Cohort study ,Adult ,TRAUMATIC BRAIN-INJURY ,Pressure support ventilation ,mechanical ventilation ,prognosis factors ,ACUTE LUNG INJURY ,03 medical and health sciences ,medicine ,Humans ,Aged ,Ischemic Stroke ,Mechanical ventilation ,Noninvasive Ventilation ,business.industry ,MORTALITY ,neurologic patients ,Organ dysfunction ,030208 emergency & critical care medicine ,Length of Stay ,medicine.disease ,TRENDS ,Respiration, Artificial ,030228 respiratory system ,Etiology ,NEUROCRITICAL CARE ,Nervous System Diseases ,Tracheotomy ,business - Abstract
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease.
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- 2021
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23. Estimation of noise radiation including airborne noise using the in-situ blocked force approach (Third report, experimental verification of the estimation method by application to rattle noise from an electric power steering system)
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Jan-Welm Biermann, Jens Viehöfer, Jan Hendrik Elm, Nobuyuki Iwatsuki, and Yoshihiro Sato
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Noise ,Computer science ,Acoustics ,Steering system ,Electric power steering ,Radiation - Published
- 2020
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24. Anterior talofibular ligament lesion is associated with increased flat foot deformity but does not affect correction by lateral calcaneal lengthening
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Dominic Rigling, Stefan Zimmermann, Lukas Jud, Tobias Götschi, Arnd F. Viehöfer, Stephan H. Wirth, Sarvpreet Singh, University of Zurich, and Jud, Lukas
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Male ,lcsh:Diseases of the musculoskeletal system ,Sports medicine ,2745 Rheumatology ,Radiography ,0302 clinical medicine ,Bone Lengthening ,Risk Factors ,Orthopedics and Sports Medicine ,Orthodontics ,030222 orthopedics ,Anterior talofibular ligament ,Middle Aged ,Magnetic Resonance Imaging ,Osteotomy ,Treatment Outcome ,medicine.anatomical_structure ,Preoperative Period ,Ligament ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Female ,medicine.symptom ,Research Article ,Adult ,Lateral calcaneal lengthening ,medicine.medical_specialty ,610 Medicine & health ,Lesion ,03 medical and health sciences ,2732 Orthopedics and Sports Medicine ,Rheumatology ,Adult acquired flatfoot ,Internal medicine ,medicine ,Humans ,Flatfoot correction ,Foot deformity ,Retrospective Studies ,business.industry ,030229 sport sciences ,medicine.disease ,Flatfoot ,Calcaneus ,Orthopedic surgery ,lcsh:RC925-935 ,Lateral Ligament, Ankle ,business ,Follow-Up Studies - Abstract
Background Several risk factors for adult acquired flatfoot deformity (AAFD) have been identified in literature. To this date, little attention has been paid to the lateral ligament complex and its influence on AAFD, although its anatomic course and anatomic studies suggest a restriction to flatfoot deformity. The aim of this study was to assess the influence of the anterior talofibular ligament (ATFL) on AAFD and on radiologic outcome following common operative correction by lateral calcaneal lengthening. Methods We reviewed all patients that underwent lateral calcaneal lengthening for correction of AAFD between January 2008 and July 2018 at our clinic. Patients were grouped according to the preoperative MRI findings into those with an intact ATFL and those with an injured ATFL. Two independent readers assessed common radiographic flatfoot parameters on preoperative and postoperative radiographs. Results Sixty-four flatfoot corrections in 63 patients were included, whereby the ATFL was intact in 29 cases, and in 35 cases the ligament was injured. An ATFL lesion was overall radiologically associated with increased flatfoot deformity with a statistically significant difference between the two groups for preoperative talometatarsal-angle (p = 0.002), talocalcaneal-angle (p = 0.000) and talonavicular uncoverage-angle (p = 0.005). No difference between the two groups could be observed regarding the success of operative correction or operative consistency after lateral calcaneal lengthening. Conclusion The ATFL seems to influence the extent of AAFD. In patients undergoing lateral calcaneal lengthening, the integrity of the ligament seems not to influence the degree of correction or the consistency of the postoperative result., BMC Musculoskeletal Disorders, 20 (1), ISSN:1471-2474
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- 2019
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25. Classification of three corynebacterial strains isolated from a small paddock in North Rhine-Westphalia: proposal of
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Lena, Schaffert, Matthias, Ruwe, Johanna, Milse, Katharina, Hanuschka, Vera, Ortseifen, Julian, Droste, David, Brandt, Laura, Schlüter, Yvonne, Kutter, Svenja, Vinke, Prisca, Viehöfer, Lucas, Jacob, Nils-Christian, Lübke, Eva, Schulte-Berndt, Carsten, Hain, Marten, Linder, Pascal, Schmidt, Lars, Wollenschläger, Tobias, Luttermann, Eric, Thieme, Julia, Hassa, Markus, Haak, Manuel, Wittchen, Almut, Mentz, Marcus, Persicke, Tobias, Busche, and Christian, Rückert
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DNA, Bacterial ,Base Composition ,Farms ,Pigmentation ,Germany ,RNA, Ribosomal, 16S ,Fatty Acids ,Sequence Analysis, DNA ,Corynebacterium ,Phylogeny ,Soil Microbiology ,Bacterial Typing Techniques - Abstract
Three novel corynebacterial species were isolated from soil sampled at a paddock in Vilsendorf, North Rhine-Westphalia, Germany. The strains were coccoid or irregular rod-shaped, catalase-positive and pale white to yellow-orange in colour. By whole genome sequencing and comparison of the 16S rRNA genes as well as the whole genome structure, it was shown that all three strains represent novel species of the family
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- 2021
26. Joint-line medialization after anatomical total shoulder replacement requires more rotator cuff activity to preserve joint stability
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Elias Bachmann, Arnd F. Viehöfer, Karl Wieser, Andrew Ker, Christian Gerber, Anita Hasler, University of Zurich, and Hasler, Anita
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musculoskeletal diseases ,Shoulder ,Shoulder surgery ,medicine.medical_treatment ,Joint stability ,610 Medicine & health ,Diseases of the musculoskeletal system ,Joint-line ,Trauma ,Instability ratio ,03 medical and health sciences ,2732 Orthopedics and Sports Medicine ,0302 clinical medicine ,Deltoid muscle ,Joint line ,medicine ,Orthopedics and Sports Medicine ,Rotator cuff ,Medialization ,Joint (geology) ,Orthopedic surgery ,Orthodontics ,030222 orthopedics ,Lateralization ,business.industry ,030229 sport sciences ,Total shoulder replacement ,Arthroplasty ,2746 Surgery ,medicine.anatomical_structure ,Total shoulder arthroplasty ,RC925-935 ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Surgery ,Muscle forces ,business ,RD701-811 - Abstract
Background The biomechanical effects of joint-line medialization during shoulder surgery are poorly understood. It was therefore the purpose of this study to investigate whether medialization of the joint line especially associated with total shoulder arthroplasty leads to changes in the rotator cuff muscle forces required to stabilize the arm in space. Methods A validated computational 3-D rigid body simulation model was used to calculate generated muscle forces, instability ratios, muscle-tendon lengths and moment arms during scapular plane elevation. Measurements took place with the anatomical and a 2 mm and 6 mm lateralized or medialized joint line. Results When the joint line was medialized, increased deltoid muscle activity was recorded throughout glenohumeral joint elevation. The rotator cuff muscle forces increased with medialization of the joint line in the early phases of elevation. Lateralization of the joint line led to higher rotator cuff muscle forces after 52° of glenohumeral elevation and to higher absolute values in muscle activity. A maximum instability ratio of >0.6 was recorded with 6 mm of joint-line medialization. Conclusion In this biomechanical study, medialization and lateralization of the normal joint line during total shoulder arthroplasty led to substantial load changes on the shoulder muscles used for stabilizing the arm in space. Specifically, medialization does not only lead to muscular shortening but also to increased load on the supraspinatus tendon during early arm elevation, the position which is already most loaded in the native joint.
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- 2021
27. Talus morphology differs between flatfeet and controls, but its variety has no influence on extent of surgical deformity correction
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Silvan Beeler, Stephan H. Wirth, Andreas Flury, Florian B. Imhoff, Arndt Viehöfer, Julian Hasler, University of Zurich, and Flury, Andreas
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medicine.medical_specialty ,medicine.medical_treatment ,610 Medicine & health ,Osteotomy ,Flatfeet ,Talus ,03 medical and health sciences ,0302 clinical medicine ,2732 Orthopedics and Sports Medicine ,Subtalar joint ,Deformity ,medicine ,Humans ,Orthopedics and Sports Medicine ,Foot deformity ,Orthodontics ,030222 orthopedics ,biology ,Foot ,business.industry ,Forefoot ,030229 sport sciences ,General Medicine ,biology.organism_classification ,medicine.disease ,Flatfoot ,2746 Surgery ,Calcaneus ,Valgus ,medicine.anatomical_structure ,Orthopedic surgery ,Surgery ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,medicine.symptom ,business - Abstract
Background Progressive collapsing foot deformity (PCFD) is a complex 3-dimensional (3-D) deformity with varying degrees of hindfoot valgus, forefoot abduction, and midfoot varus. The first aim of this study was to perform a 3-D analysis of the talus morphology between symptomatic PCFD patients that underwent operative flatfoot correction and controls. The second aim was to investigate if there is an impact of individual talus morphology on the success of operative flatfoot correction. Methods We reviewed all patients that underwent lateral calcaneal lengthening for correction of PCFD between 2008 and 2018 at our clinic. Radiographic flatfoot parameters on preoperative and postoperative radiographs were assessed. Additionally, 3-D surface models of the tali were generated using computed tomography (CT) data. The talus morphology of 44 flatfeet was compared to 3-D models of 50 controls without foot or ankle pain of any kind. Results Groups were comparable regarding demographics. Talus morphology differed significantly between PCFD and controls in multiple aspects. There was a 2.6° increased plantar flexion (22.3° versus 26°; p = 0.02) and medial deviation (31.7° and 33.5°; p = 0.04) of the talar head in relation to the body in PCFD patients compared to controls. Moreover, PCFD were characterized by an increased valgus (difference of 4.6°; p = 0.01) alignment of the subtalar joint. Satisfactory correction was achieved in all cases, with an improvement of the talometatarsal-angle and the talonavicular uncoverage angle of 5.6° ± 9.7 (p = 0.02) and 9.9° ± 16.3 (p = 0.001), respectively. No statistically significant correlation was found between talus morphology and the correction achieved or loss of correction one year postoperatively. Conclusion The different morphological features mentioned above might be contributing or risk factors for progression to PCFD. However, despite the variety of talar morphology, which is different compared to controls, the surgical outcome of calcaneal lengthening osteotomy was not affected. Level of evidence III.
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- 2021
28. Clinical and Functional Outcomes of Peroneus Longus to Brevis Tendon Transfer
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Stephan H. Wirth, Stefan Fröhlich, Florian B. Imhoff, Octavian Andronic, Arnd F. Viehöfer, Marco D. Burkhard, University of Zurich, and Imhoff, Florian B
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Tendon Transfer ,Tenodesis ,610 Medicine & health ,Tendon ,Surgery ,Peroneal tendon ,2746 Surgery ,Tendons ,medicine.anatomical_structure ,2732 Orthopedics and Sports Medicine ,Tendon transfer ,Peroneus longus ,Humans ,Medicine ,Orthopedics and Sports Medicine ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Muscle, Skeletal ,business ,Ankle Joint - Abstract
Background: Peroneal tendon lesions can cause debilitating pain, but operative treatment remains controversial. Some studies recommend peroneal tenodesis or transfer if more than half of the tendon is affected. However, clinical outcomes and inversion/eversion motion after peroneal transfer have not been investigated yet. Methods: Patients who underwent distal peroneus longus to brevis transfer for major peroneus brevis tendon tears with a minimum follow-up of 2 years were included. Clinical outcome parameters included the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score, the German Foot Function Index (FFI-D), and Karlsson-Peterson score. Functional outcome was tested with a standardized active range-of-motion (ROM) and isokinetic strength measurement protocol, including concentric and eccentric eversion and inversion tests. Results: Of total 23 eligible patients, 14 (61%) were available for follow-up. Clinical outcome scores were good with AOFAS 86 ± 16 points, FFI-D pain 26% and FFI-D disability 26%, and Karlsson-Peterson score 78 ± 23 points. There was no difference in strength in comparison to the contralateral foot (all P > .05). Isokinetic strength was 16.3 ± 4.9 Nm (108% of contralateral side) and 18.8 ± 4.5 Nm (101%) at concentric 30 deg/s and eccentric 30 deg/s eversion tests, as well as 15.7 ± 5.2 Nm (102%) and 18.7 ± 3.3 Nm (103%) at concentric 30 deg/s and eccentric 30 deg/s inversion tests, respectively. There was no difference in ROM compared to the contralateral side (eversion/inversion 14.5-0-18.7 vs 14.1-0-16.1 degrees). Conclusion: Peroneus longus to brevis transfer is a viable option for treating severe peroneus brevis tendon tears and does not compromise measurable strength or ROM in inversion or eversion in comparison to the contralateral ankle joint. Level of Evidence: Level IV, prospective case series.
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- 2021
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29. Autologous Matrix-Induced Chondrogenesis With Lateral Ligament Stabilization for Osteochondral Lesions of the Talus in Patients With Ankle Instability
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Stephan H. Wirth, Christoph Germann, Fabio A. Casari, Arnd F. Viehöfer, Lizzy Weigelt, Jakob Ackermann, University of Zurich, and Ackermann, Jakob
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lateral ligament stabilization ,medicine.medical_specialty ,business.industry ,ankle instability ,Articular cartilage ,610 Medicine & health ,talus ,Chondrogenesis ,Article ,Surgery ,Autologous matrix-induced chondrogenesis ,medicine.anatomical_structure ,2732 Orthopedics and Sports Medicine ,ankle ,Ligament ,Medicine ,osteochondral lesion ,Orthopedics and Sports Medicine ,In patient ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,articular cartilage ,Ankle ,business ,Ankle instability ,AMIC - Abstract
Background:Autologous matrix-induced chondrogenesis (AMIC) has been shown to result in favorable clinical outcomes in patients with osteochondral lesions of the talus (OLTs). Though, the influence of ankle instability on cartilage repair of the ankle has yet to be determined.Purpose/Hypothesis:To compare the clinical and radiographic outcomes in patients with and without concomitant lateral ligament stabilization (LLS) undergoing AMIC for the treatment of OLT. It was hypothesized that the outcomes would be comparable between these patient groups.Study Design:Cohort study; Level of evidence, 3.Methods:Twenty-six patients (13 with and 13 without concomitant ankle instability) who underwent AMIC with a mean follow-up of 4.2 ± 1.5 years were enrolled in this study. Patients were matched 1:1 according to age, body mass index (BMI), lesion size, and follow-up. Postoperative magnetic resonance imaging and Tegner, American Orthopaedic Foot & Ankle Society (AOFAS), and Cumberland Ankle Instability Tool (CAIT) scores were obtained at a minimum follow-up of 2 years. A musculoskeletal radiologist scored all grafts according to the MOCART (magnetic resonance observation of cartilage repair tissue) 1 and MOCART 2.0 scores.Results:The patients’ mean age was 33.4 ± 12.7 years, with a mean BMI of 26.2 ± 3.7. Patients with concomitant LLS showed worse clinical outcome measured by the AOFAS (85.1 ± 14.4 vs 96.3 ± 5.8; P = .034) and Tegner (3.8 ± 1.1 vs 4.4 ± 2.3; P = .012) scores. Postoperative CAIT and AOFAS scores were significantly correlated in patients with concomitant LLS ( r = 0.766; P = .002). A CAIT score >24 (no functional ankle instability) resulted in AOFAS scores comparable with scores in patients with isolated AMIC (90.1 ± 11.6 vs 95.3 ± 6.6; P = .442). No difference was seen between groups regarding MOCART 1 and 2.0 scores ( P = .714 and P = .371, respectively).Conclusion:Concurrently performed AMIC and LLS in patients with OLT and ankle instability resulted in clinical outcomes comparable with isolated AMIC if postoperative ankle stability was achieved. However, residual ankle instability was associated with worse postoperative outcomes, highlighting the need for adequate stabilization of ankle instability in patients with OLT.
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- 2020
30. Treatment of hindfoot and ankle infections with Ilizarov external fixator or spacer, followed by secondary arthrodesis
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Arnd F. Viehöfer, Tobias Götschi, Rebecca Hartmann, Florian Grubhofer, Stephan H. Wirth, Felix W A Waibel, University of Zurich, and Hartmann, Rebecca
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medicine.medical_specialty ,External fixator ,External Fixators ,medicine.medical_treatment ,Arthrodesis ,0206 medical engineering ,Cement spacer ,610 Medicine & health ,02 engineering and technology ,Ilizarov Technique ,03 medical and health sciences ,0302 clinical medicine ,2732 Orthopedics and Sports Medicine ,medicine ,Infection control ,Humans ,Orthopedics and Sports Medicine ,Retrospective Studies ,030203 arthritis & rheumatology ,business.industry ,Osteomyelitis ,medicine.disease ,020601 biomedical engineering ,Surgery ,Anti-Bacterial Agents ,medicine.anatomical_structure ,Treatment Outcome ,Amputation ,Radiological weapon ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Ankle ,business ,Ankle Joint - Abstract
An established treatment strategy in surgical site infection after hindfoot and ankle surgery is a two-stage procedure with debridement and placement of a cement spacer, followed by antibiotic treatment and secondary arthrodesis. However, there is little evidence to favor this treatment over a one-stage procedure with debridement, followed by primary arthrodesis with an Ilizarov external fixator and antibiotic treatment. We compared the infection control and clinical and radiological outcome of a two-stage and a one-stage procedure. In this study, 7 patients with a two-stage revision and 11 patients with a one-stage revision between 2005 and 2015 were included. The primary outcome was infection control (absence of the Musculoskeletal Infection Society PJI criteria) 2 years after the ankle or hindfoot arthrodesis. Secondary outcome measures were the AOFAS hindfoot score and radiological consolidation rate. Infection control was 85% (6 out of 7 patients) in the two-stage group and 81% (9 out of 11 patients) in the one-stage group (p = 1.0). One patient (14%) of the two-stage and two patients (18%) in the one-stage group needed below-knee amputation. In the two-stage group, the mean postoperative AOFAS score was 74.8 (SD: ±11.3) versus 71.7 (SD: ±17.8) in the one-stage group. Radiological consolidation could be achieved in 71% in the spacer group (n = 5) and in 72% in the Ilizarov external fixator group (n = 9). Infection control, AOFAS score, and radiologic consolidation of hindfoot and ankle arthrodesis were comparable in both groups of patients with complicated postsurgical hindfoot or ankle infections.
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- 2020
31. Talar neck angle correlates with tibial torsion-Guidance for 3D and 2D measurements in total ankle replacement
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Flury, Andreas, Viehöfer, Arnd F, Hoch, Armando, Vlachopoulos, Lazaros, Wirth, Stephan H, Imhoff, Florian B, University of Zurich, and Flury, Andreas
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musculoskeletal diseases ,Adult ,Male ,Adolescent ,medicine.medical_treatment ,0206 medical engineering ,Ankle replacement ,610 Medicine & health ,02 engineering and technology ,Talus ,03 medical and health sciences ,Arthroplasty, Replacement, Ankle ,Young Adult ,2732 Orthopedics and Sports Medicine ,0302 clinical medicine ,Imaging, Three-Dimensional ,Subtalar joint ,medicine ,Image Processing, Computer-Assisted ,Humans ,Orthopedics and Sports Medicine ,Tibia ,030203 arthritis & rheumatology ,Orthodontics ,business.industry ,Torsion (mechanics) ,Middle Aged ,musculoskeletal system ,020601 biomedical engineering ,body regions ,Transverse plane ,medicine.anatomical_structure ,Torque ,Coronal plane ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Tibial torsion ,Female ,Stress, Mechanical ,Ankle ,business ,Tomography, X-Ray Computed ,human activities ,Ankle Joint - Abstract
Axial plane alignment of the talar component in total ankle arthroplasty is poorly understood and remains a major issue, especially since malpositioning results in increased peak pressure and rotational torque. Further profound knowledge regarding individual anatomy of the talus and its relation to proximal and distal osseous structures is therefore needed. Therefore, three-dimensional (3D) surface models of 50 lower extremities were generated using computed tomography data of patients without ankle osteoarthritis. The talus neck torsion was measured using a novel 3D measurement method. Then, tibial torsion and subtalar joint axis orientation were measured and correlated to the talus neck torsion. Moreover, a 2D measurement method of the talus neck torsion was developed. A statistically significant correlation was found between external tibia torsion and medial talus neck torsion, as well as talus neck axis and subtalar joint axis in the transversal and frontal plane. The novel defined 3D measurement methods indicated excellent inter-rater and intra-rater reliability. The 2D measurement method of the talus neck torsion was in good agreement with the 3D method. The results showed that the rotational profiles of the tibia, talus, and adjacent joints are interconnected, which should be considered in total ankle replacement (TAR). Clinical relevance: This study improves the overall understanding of the talar anatomy, as well as its relationship to adjacent osseous structures. The novel 2D measurement method of the talus neck torsion might improve talar component positioning in the axial plane corresponding to the patient's individual anatomy, and therefore improve the survival rate of TAR.
- Published
- 2020
32. Minimally invasive arthrodesis of the first metatarsophalangeal joint: A systematic literature review
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Stephan H. Wirth, Sandro Hodel, Arnd F. Viehöfer, University of Zurich, and Hodel, Sandro
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Metatarsophalangeal Joint ,Reoperation ,medicine.medical_specialty ,Arthrodesis ,medicine.medical_treatment ,610 Medicine & health ,03 medical and health sciences ,Hallux rigidus ,0302 clinical medicine ,Postoperative Complications ,2732 Orthopedics and Sports Medicine ,Osteogenesis ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Orthopedics and Sports Medicine ,030222 orthopedics ,business.industry ,030229 sport sciences ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Systematic review ,Radiological weapon ,Orthopedic surgery ,Hallux ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Ankle ,Complication ,business ,Cohort study - Abstract
Aim Currently, cohort studies reported the use of minimally invasive arthrodesis of the first metatarsophalangeal joint (MTP I). The aim of this systematic literature review was to analyse clinical, radiological outcome and complications with this technique. Methods A systemic literature search of the databases Google Scholar, PubMed, Scopus, EMBASE and Cochrane to identify studies reporting on clinical, radiological outcome or complications of minimally invasive MTP I arthrodesis was conducted. Results A total of 6 studies (1 Level V, 5 Level IV) reporting on 109 minimally invasive MTP arthrodesis in 105 patients were included. Validated scores were reported in 103 cases. Clinical outcome improved in 57 cases from a mean of 36.9 to 82.6 points American Orthopedic Foot and Ankle Score (AOFAS) and in 46 cases from 38.7 to 18.4 points Manchester Oxford Foot Questionnaire (MOXFQ). Radiological fusion rate was 87% (n = 94 out of 109) achieved after 6-12 weeks. Overall complication rate was 11.9% (13 cases) leading to revision surgeries in 5.5% (6 cases). Most common complications Most common complications were symptomatic non-union (n = 6, 5.5%), asymptomatic non-union (n = 2, 1.8%) and subsequent interphalangeal joint arthritis (n = 2, 1.8%). Conclusion Minimally invasive MTP I arthrodesis is a promising technique with comparable clinical, radiological outcome and complication rates to open surgery in hallux rigidus and rigido-valgus. Future studies are needed providing higher level of evidence to prove the potential benefit of minimally invasive compared to open MTP I arthrodesis.
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- 2020
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33. Plantar Fasciitis in Diabetic Foot Patients: Risk Factors, Pathophysiology, Diagnosis, and Management
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Gariani, Karim, Waibel, Felix W A, Viehöfer, Arnd F, Uçkay, Ilker, University of Zurich, and Gariani, Karim
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ddc:616 ,Diabetic foot ,3004 Pharmacology ,2724 Internal Medicine ,Epidemiology ,Diagnosis ,Plantar fasciitis ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity] ,Management - Abstract
Karim Gariani,1 Felix WA Waibel,2 Arnd F Viehöfer,2 Ilker Uçkay3 1Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland; 2Foot and Ankle Service, Department of Orthopedic Surgery, Balgrist University Hospital, Zurich, Switzerland; 3Unit for Clinical and Applied Research, Balgrist University Hospital, Zurich, SwitzerlandCorrespondence: Karim GarianiEndocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, SwitzerlandEmail Karim.gariani@hcuge.chAbstract: Plantar fasciitis (PF) is a common degenerative disorder and a frequent cause of heel pain, mostly affecting patients in their fourth and fifth decades. Diabetic patients are particularly at risk due to the presence of common risks and co-morbidities such as obesity or a sedentary lifestyle. The diagnosis of PF is mainly clinical. Imaging is not recommended for the initial approach. The initial management is conservative and should include physiotherapy, off-loading, stretching exercises, and nonsteroidal anti-inflammatory drugs. Glucocorticoid injections or surgery is an option at a later stage in recalcitrant cases. The overall management of PF does not differ between patients with diabetic foot problems and non-diabetic patients, although the details can differ. This narrative review summarizes the stateoftheart in terms of the risk factors, pathophysiology, diagnosis, assessment, and management of PF in diabetic patients.Keywords: plantar fasciitis, diabetic foot, management, epidemiology, diagnosis
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- 2020
34. Arthrodesen am oberen Sprunggelenk: Verschiedene Indikationen, verschiedeneOsteosynthesen
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Viehöfer, A F, Camenzind, R S, Imhoff, F B, Wirth, S H, University of Zurich, and Wirth, S H
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2732 Orthopedics and Sports Medicine ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center - Published
- 2020
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35. Mid‑term walking ability after Charcot foot reconstruction using the Ilizarov ring fixator
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Wirth, Stephan H, Viehöfer, Arnd F, Tondelli, Timo, Hartmann, Rebecca, Berli, Martin C, Böni, Thomas, Waibel, F W A, University of Zurich, and Waibel, F W A
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2732 Orthopedics and Sports Medicine ,610 Medicine & health ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,2746 Surgery - Published
- 2020
36. Autologous Matrix-Induced Chondrogenesis (AMIC) with Lateral Ligament Stabilization for Osteochondral Lesions of the Talus in Patients with Ankle Instability
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Viehöfer, Arnd F., Ackermann, Jakob, Wirth, Stephan H., Casari, Fabio A., Weigelt, Lizzy, and Germann, Christoph
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Orthopedic surgery ,Article ,RD701-811 - Abstract
Category: Ankle; Hindfoot; Sports Introduction/Purpose: Autologous matrix-induced chondrogenesis (AMIC) has shown to result in favorable clinical outcome in patients with osteochondral lesions of the talus (OLT). Yet, the influence of ankle instability on cartilage repair of the ankle has still to be determined. This study sought to compare the clinical and radiographic outcome in patients with and without concomitant lateral ligament stabilization (LLS) undergoing AMIC for the treatment of OLT. Methods: This study evaluated AMIC that were implanted in patients for the treatment of symptomatic OLT with and without concomitant ankle instability. Postoperative MRI, Tegner, AOFAS and Cumberland Ankle Instability Tool (CAIT) were obtained at a minimum follow-up of 2 years. A musculoskeletal radiologist scored all grafts according to the MOCART 1 and 2.0 scores. Patients were stratified into two groups based on whether they underwent concomitant LLS for ankle instability. Patients without LLS served as controls. Patients were matched 1:1 for BMI, lesion size, follow-up and age. Results: Twenty-six patients that underwent AMIC with a mean follow-up of 4.2 +- 1.5 years were enrolled in this study (13 with and 13 without concomitant ankle instability). Patients' mean age was 33.4 +- 12.7 years with a BMI averaging 26.2 +- 3.7. Patients with concomitant LLS showed worse clinical outcome measured by AOFAS (85.1 +- 14.4 vs. 96.3 +- 5.8, p=0.034) and Tegner (3.8 +- 1.1 vs. 4.4 +- 2.3, p=0.012). No difference was seen between both groups regarding MOCART 1 and 2.0 scores (p=0.714 and p=0.371, respectively). Additionally, postoperative CAIT and AOFAS significantly correlated in patients that underwent concomitant LLS (r=0.766, p=0.002) with a CAIT score of > 24 (stable ankle joint) resulting in AOFAS scores comparable to scores in patients with isolated AMIC (90.1 +- 11.6 vs. 95.3 +- 6.6; p=0.442). Conclusion: The results of this study suggest a negative influence of ankle instability on the clinical outcome of cartilage repair with AMIC for the treatment of OLT. If postoperative ankle stability is achieved in patients with LLS, however, comparable outcome as seen after isolated AMIC can be expected.
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- 2022
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37. Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: A 10-year follow-up
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Andreas Hingsammer, B. Brand, Arnd F. Viehöfer, Reto Sutter, David E. Bauer, Stephan H. Wirth, Franziska Eckers, University of Zurich, and Eckers, F
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Adult ,Male ,2716 Genetics (clinical) ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Arthrodesis ,2720 Hematology ,Ankle replacement ,Periprosthetic ,610 Medicine & health ,030204 cardiovascular system & hematology ,Hemophilia A ,Arthroplasty, Replacement, Ankle ,03 medical and health sciences ,0302 clinical medicine ,Arthropathy ,medicine ,Deformity ,Humans ,Genetics (clinical) ,030222 orthopedics ,business.industry ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Arthroplasty ,Surgery ,medicine.anatomical_structure ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Female ,Ankle ,medicine.symptom ,Range of motion ,business ,Follow-Up Studies - Abstract
INTRODUCTION Haemophilic ankle arthropathy is caused by recurrent spontaneous joint haemorrhaging and leads to pain, deformity and loss of function. In the presence of advanced articular deterioration, therapeutic options are confined to either arthroplasty or arthrodesis, the latter still being referred to as the procedure of choice. However, total ankle replacement (TAR) has recently gained acceptance as an alternative. AIM To investigate the mid- to long-term results of TAR in haemophilic ankle arthropathy. MATERIALS AND METHODS Seventeen TARs in 14 male patients (mean age: 43 years [range, 27.4-57.6]), implanted between 1998 and 2012, were retrospectively analysed. Implant survival was estimated using Kaplan-Meier analysis. Haemophilic/viral status, complications and revision surgeries were recorded. Follow-up assessment of 12 TARs was performed 9.6 years (range, 3.3-17.8) postoperatively, including clinical examination, pain and satisfaction scales, the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score, and the SF-36. Radiographic evaluation of pre- and follow-up radiographs was conducted. RESULTS Estimated implant survival was 94% at 5, 85% at 10 and 70% at 15 years, respectively. Three cases required revision surgery. At follow-up, 9.6 years (range, 3.3-17.8) postoperatively, the level of satisfaction was 76% (range, 50-100) and of pain 2/10 (range, 0-6) on the VAS. Range of motion had increased significantly (P = .037). The SF-36 summary scores were comparable to those of a matched standard population. The AOFAS hindfoot score averaged 81 points (range, 73-90). All radiographs revealed component loosening or periprosthetic radiolucency. CONCLUSION Total ankle replacement in the presence of advanced haemophilic arthropathy is a viable treatment option with favourable mid-/long-term results, maintaining mobility of the ankle joint.
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- 2017
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38. Mid-term walking ability after Charcot foot reconstruction using the Ilizarov ring fixator
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Stephan H. Wirth, Thomas Böni, Timo Oliver Tondelli, Martin C Berli, Felix W A Waibel, Arnd F. Viehöfer, and Rebecca Hartmann
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Adult ,Male ,medicine.medical_specialty ,External Fixators ,Limb salvage ,medicine.medical_treatment ,Ilizarov Technique ,Walking ,Amputation, Surgical ,03 medical and health sciences ,External fixation ,0302 clinical medicine ,Arthropathy ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Mobility Limitation ,Retrospective Studies ,030222 orthopedics ,business.industry ,Osteomyelitis ,030229 sport sciences ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Limb Salvage ,Diabetic Foot ,Surgery ,Exact test ,Treatment Outcome ,Orthopedic surgery ,Ambulatory ,Foot reconstruction ,Female ,Arthropathy, Neurogenic ,business - Abstract
Failed conservative treatment and complications are indications for foot reconstruction in Charcot arthropathy. External fixation using the Ilizarov principles offers a one-stage procedure for deformity correction and resection of osteomyelitic bone. The aim of this study was to determine whether external fixation with an Ilizarov ring fixator leads reliably to walking ability. 29 patients treated with an Ilizarov ring fixator for Charcot arthropathy were retrospectively analyzed. Radiologic fusion at final follow up was assessed separately on conventional X-rays by two authors. The association between walking ability and the presence of osteomyelitis at the time of reconstruction, and the presence of fusion at final follow up was investigated using Fisher’s exact test. Mean follow up was 35 months (range 5.3–107) months; mean time of external fixation was 113 days. Ten patients (34.5%) reached fusion, but 19 did not (65.5%). Two patients needed below knee amputation. 26 of the remaining 27 patients maintained walking ability, 23 of those without assistive devices. Walking ability was independent from the presence of osteomyelitis at the time of reconstruction and from the presence of fusion. Foot reconstruction with an Ilizarov ring fixator led to limb salvage in 93%. The vast majority (96.3%) of patients with successful limb salvage was ambulatory, independent from radiologic fusion, and presence of osteomyelitis at the time of reconstruction. These findings encourage limb salvage and deformity correction in this difficult-to-treat disease, even with underlying osteomyelitis.
- Published
- 2019
39. Acoustic Vehicle Alerting Systems (AVAS) - Regulations, Realization and Sound Design Challenges
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Alessandro Fortino, Jens Viehöfer, Jürgen Pampel, and Lutz Eckstein
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Engineering ,Injury control ,Accident prevention ,business.industry ,020209 energy ,Sound design ,020208 electrical & electronic engineering ,Poison control ,02 engineering and technology ,General Medicine ,Automotive engineering ,Noise ,0202 electrical engineering, electronic engineering, information engineering ,Systems engineering ,business ,Realization (systems) - Published
- 2016
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40. Open Meniscus Repair In Full And Partial Horizontal Meniscal Lesions : A Biomechanical Cadaver Study
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Felix Wa, Waibel, Elias, Bachmann, Arnd F, Viehöfer, Katharina, Schürholz, Jess G, Snedeker, and Sandro F, Fucentese
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Weight-Bearing ,Sutures ,Cadaver ,Animals ,Cattle ,Stress, Mechanical ,Biomechanical Phenomena ,Tibial Meniscus Injuries - Abstract
Horizontal meniscal tears are often treated by partial meniscectomy. Some clinical studies have shown successful repair. The purpose of this study was to show that axial loading causes less horizontal displacement in partial than in total horizontal lesions and that suture of those lesions prevents horizontal displacement. Forty menisci were tested : sutured partial horizontal lesions (ten), sutured total horizontal lesions (ten) and matched unsutured control groups (ten each). Samples were put in a custom made fixation device. 1000 cycles with axial loading, simulating partial weight-bearing of 15kg, were applied. Displacement was measured and construct stiffness was calculated. No suture failure or pullout occurred. Horizontal displacement was insignificantly lower in partial then in full lesions as well as in sutured samples than in the control groups. Horizontal displacement is low in both sutured and unsutured menisci in our test setting. Further studies with higher loads are required.
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- 2018
41. Augmented Reality Guided Osteotomy in Hallux Valgus Surgery
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Stephan H. Wirth, Arnd F. Viehöfer, Cyrill Dennler, Mazda Farshad, Philipp Fürnstahl, Stefan Zimmermann, and Jaberg Laurenz
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Valgus ,medicine.medical_specialty ,lcsh:RD701-811 ,biology ,lcsh:Orthopedic surgery ,business.industry ,medicine.medical_treatment ,medicine ,Augmented reality ,biology.organism_classification ,Osteotomy ,business ,Surgery - Abstract
Category: Bunion Introduction/Purpose: An optimal osteotomy angle can avoid shortening of the first metatarsal bone after hallux valgus surgery and therefore reduce the risk of transfer-metatarsalgia. Up to date the osteotomy is performed free-hand without guidance and is therefore prone to unwanted variability in accuracy. The purpose of the present ex-vivo study was to investigate whether overlaying a hologram (augmented reality, AR) would improve accuracy of the distal osteotomy during hallux valgus surgery. Methods: A polyamide foot skeleton was constructed based a CT scan of a cadaveric foot and covered with medical silicon soft tissue. Three different polyamide first metatarsals were inserted to simulate a light, moderate and severe hallux valgus deformity. Distal Osteotomies of the first metatarsals were performed by two surgeons with different levels of surgical experience each with (AR, n=15x2) or without (controls, n=15x2) overlay of a hologram depicting an angle of osteotomy perpendicular to the second metatarsal in the transverse plane. Subsequently, the deviation to the plumb line of the second metatarsal in the transverse plane of all 60 osteotomies angles were optically measured and statistically analyzed. Results: Overall, the AR-guided osteotomies were more accurate (4.9 ± 4.2°) compared to the freehand cuts (6.7± 6.1°) by tendency (p=0.2). However, while the inexperienced surgeon performed more accurate osteotomies with AR with a mean angle of 6.4± 3.5° compared to freehand 10.5 ± 5.5° (p=0.02), no significant difference was noticed for the experienced surgeon with an osteotomy angle of around 3° in both cases. Conclusion: This pilot-study suggests that augmented reality guided osteotomies can potentially improve accuracy during hallux valgus surgery, particularly for less experienced surgeons. However, clinical studies are needed to investigate the clinical benefit of augmented reality in hallux valgus surgery.
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- 2018
42. Open Technique for In Situ Subtalar Fusion
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Stefan Zimmermann, Arnd F. Viehöfer, Stephan H. Wirth, University of Zurich, and Wirth, Stephan H
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musculoskeletal diseases ,Arthrodesis ,medicine.medical_treatment ,610 Medicine & health ,03 medical and health sciences ,0302 clinical medicine ,2732 Orthopedics and Sports Medicine ,Subtalar fusion ,Subtalar joint ,medicine ,Humans ,Orthopedics and Sports Medicine ,Orthodontics ,030222 orthopedics ,business.industry ,Subtalar Joint ,030229 sport sciences ,2746 Surgery ,body regions ,Conservative treatment ,medicine.anatomical_structure ,Surgery ,10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center ,Joint Diseases ,business ,human activities - Abstract
The subtalar joint plays an important role for the hindfoot when accommodating during gait. Joint degeneration may be caused by posttraumatic, inflammatory, and pathologic biomechanical changes. Once conservative treatment has failed, subtalar fusion should be considered. The indication for surgery is based on thorough clinical and radiographic evaluation. Several techniques for subtalar fusion are published in literature. This article aims to describe a technique for in situ arthrodesis of the subtalar joint, paying special attention to biomechanical aspects as well as preoperative clinical and radiological work-up.
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- 2018
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43. Glenohumeral joint reaction forces increase with critical shoulder angles representative of osteoarthritis-A biomechanical analysis
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Jess G. Snedeker, Arnd F. Viehöfer, Daniel Baumgartner, and Christian Gerber
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Orthodontics ,030222 orthopedics ,medicine.medical_specialty ,Shoulders ,business.industry ,Deltoid curve ,Biomechanics ,030229 sport sciences ,Osteoarthritis ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Physical therapy ,Orthopedics and Sports Medicine ,Humerus ,Shoulder joint ,business ,Range of motion ,Joint (geology) - Abstract
Osteoarthritis (OA) of the glenohumeral joint constitutes the most frequent indication for nontraumatic shoulder joint replacement. Recently, a small critical shoulder angle (CSA) was found to be associated with a high prevalence of OA. This study aims to verify the hypothesis that a small CSA leads to higher glenohumeral joint reaction forces during activities of daily living than a normal CSA. A shoulder simulator with simulated deltoid (DLT), supraspinatus (SSP), infraspinatus/teres minor (ISP/TM), and subscapularis (SSC) musculotendinous units was constructed. The DLT wrapping on the humerus was simulated using a pulley that could be horizontally adjusted to simulate the 28° CSA found in OA or the 33° CSA found in disease-free shoulders. Over a range of motion between 6° and 82° of thoracohumeral abduction joint forces were measured using a six-axis load cell. An OA-associated CSA yielded higher net joint reaction forces than a normal CSA over the entire range of motion. The maximum difference of 26.4 N (8.5%) was found at 55° of thoracohumeral abduction. Our model thus suggests that a CSA typical for OA predisposes the glenohumeral joint to higher joint reaction forces and could plausibly play a role in joint overloading and development of OA. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1047-1052, 2016.
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- 2016
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44. A larger critical shoulder angle requires more rotator cuff activity to preserve joint stability
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Philippe Favre, Elias Bachmann, Arnd F. Viehöfer, Christian Gerber, and Jess G. Snedeker
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Orthodontics ,030222 orthopedics ,business.industry ,Shoulders ,Rotator cuff injury ,Biomechanics ,Joint stability ,030229 sport sciences ,Anatomy ,medicine.disease ,Tendon ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Medicine ,Orthopedics and Sports Medicine ,Rotator cuff ,Shoulder joint ,Acromion ,business - Abstract
Shoulders with rotator cuff tears (RCT) tears are associated with significantly larger critical shoulder angles (CSA) (RCT CSA = 38.2°) than shoulders without RCT (CSA = 32.9°). We hypothesized that larger CSAs increase the ratio of glenohumeral joint shear to joint compression forces, requiring substantially increased compensatory supraspinatus loads to stabilize the arm in abduction. A previously established three dimensional (3D) finite element (FE) model was used. Two acromion shapes mimicked the mean CSA of 38.2° found in patients with RCT and that of a normal CSA (32.9°). In a first step, the moment arms for each muscle segment were obtained for 21 different thoracohumeral abduction angles to simulate a quasi-static abduction in the scapular plane. In a second step, the muscle forces were calculated by minimizing the range of muscle stresses able to compensate an external joint moment caused by the arm weight. If the joint became unstable, additional force was applied by the rotator cuff muscles to restore joint stability. The model showed a higher joint shear to joint compressive force for the RCT CSA (38.2°) for thoracohumeral abduction angles between 40° and 90° with a peak difference of 23% at 50° of abduction. To achieve stability in this case additional rotator cuff forces exceeding physiological values were required. Our results document that a higher CSA tends to destabilize the glenohumeral joint such that higher than normal supraspinatus forces are required to maintain modeled stability during active abduction. This lends strong support to the concept that a high CSA can induce supraspinatus (SSP) overload. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:961-968, 2016.
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- 2015
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45. Acoustic and Thermal Comfort Assessment of Innovative Heating Systems
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Jens Viehöfer, Marc Pingel, Thomas Lichius, and Damian Backes
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Engineering ,business.industry ,General Earth and Planetary Sciences ,Thermal comfort ,business ,Automotive engineering ,General Environmental Science - Published
- 2015
- Full Text
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46. Akustische und thermische Komfortuntersuchung innovativer Heizsysteme
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Jens Viehöfer, Damian Backes, Thomas Lichius, and Marc Pingel
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Automotive Engineering - Abstract
Das automatisierte Fahren wird mit einer Neugestaltung des Innenraums einhergehen, unter anderem mit neuen Technologien zur Innenraumtemperierung und Akustik. Flaechenheizsysteme stellen eine moegliche Technik dar, um eine effiziente und komfortable Temperierung des Innenraums zu erreichen. Neue Techniken muessen jedoch im Hinblick auf das akustische und thermische Wohlempfinden getestet werden. Die subjektiv empfundene Wirkung eines neuartigen Flaechenheizsystems wurde in einer innovativen Temperierakustikkammer (Automotive Interior Center - AIC) qualitativ untersucht. Die Ergebnisse der durchgefuehrten qualitativen Untersuchung der subjektiv empfundenen Wirkung eines Flaechenheizsystems geben einen Aufschluss ueber die Effizienz von Heizungssystemen sowie ueber den hiermit verbundenen Komfort. Aus energetischer Sicht erscheint der Einsatz von Flaechenheizungen zielfuehrend zu sein, um den Waermebedarf zur Temperierung der Fahrgastzelle zu reduzieren. Hinsichtlich des Komforts bieten diese Systeme zwar einen akustischen Vorteil aufgrund des Wegfalls von Lueftergeraeuschen, jedoch wird das thermische Komfortempfinden als sehr heterogen beschrieben. Unter Beruecksichtigung des geringen Energieverbrauchs fuer die Temperierung bei einem gleichzeitig akzeptablen Komfort ist die Flaechenheizung eine hervorragende Ergaenzung oder eventuell auch eine Alternative zu heutigen Heizsystemen.
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- 2015
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47. The molecular composition of the extracellular matrix of the human iliolumbar ligament
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Yasushi Shinohara, Christoph M. Sprecher, Andreas Buettner, Stefan Milz, Michael Benjamin, Bronek M. Boszczyk, and Arnd F. Viehöfer
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Adult ,Male ,Dense connective tissue ,Pathology ,medicine.medical_specialty ,Adolescent ,Matrix (biology) ,Extracellular matrix ,Young Adult ,Iliolumbar ligament ,medicine.ligament ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Aggrecans ,Collagen Type II ,Aggrecan ,Glycosaminoglycans ,Extracellular Matrix Proteins ,biology ,business.industry ,Chondroitin Sulfates ,Anatomy ,Middle Aged ,musculoskeletal system ,Enthesis ,Immunohistochemistry ,Extracellular Matrix ,medicine.anatomical_structure ,Ligaments, Articular ,biology.protein ,Ligament ,Versican ,Female ,Proteoglycans ,Surgery ,Collagen ,Neurology (clinical) ,business - Abstract
Background context The human iliolumbar ligament connects the transverse process of L5 to the iliac crest and contributes to lumbosacral stability and has been associated with low back pain. However, different opinions exist regarding the functional relevance of the ligament. Purpose In the present study, we analyze the regional molecular composition of the ligament extracellular matrix. Study design Special attention is given to the attachment sites, to determine whether the ligament is subjected to a certain mechanical environment. Methods Iliolumbar ligament samples, extending from one enthesis to the other, were removed from 11 cadavers and fixed in methanol. Cryosections were immunolabeled with a panel of antibodies directed against collagens, glycosaminoglycans, proteoglycans, matrix proteins, and neurofilament. Results The mid-substance of the ligament labeled for all the molecules normally found in dense fibrous connective tissue including types I, III, and VI collagen, versican, dermatan -, chondroitin 4 -, and keratan sulfate. However, both entheses were fibrocartilaginous and labeled for type II collagen, aggrecan, and chondroitin 6- sulfate. A common feature was fat between the fiber bundles near the entheses. Occasionally this fat contained nerve fibers. Conclusions The existence of fibrocartilaginous entheses suggests that the insertion sites of the ligament are subject to both tensile and compressive loading—probably because of insertional angle changes between ligament and bone during loading. Our findings support the suggestion that the iliolumbar ligament might play an important role in the stabilization of the lumbosacral junction.
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- 2015
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48. Der erworbene Pes planovalgus beim Erwachsenen
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Madlaina Schöni, Stephan H. Wirth, and Arnd F. Viehöfer
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- 2017
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49. Le pied plat valgus acquis chez l’adulte
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Arnd F. Viehöfer, Madlaina Schöni, and Stephan H. Wirth
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- 2017
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50. Investigation of NVH Characteristics of a Downsizing Vehicle
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Jan-Welm Biermann, Jan Hendrik Elm, and Jens Viehöfer
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Vibration ,Engineering ,Noise ,business.industry ,Noise, vibration, and harshness ,General Medicine ,business ,Automotive engineering - Published
- 2014
- Full Text
- View/download PDF
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