Author: "Vara, J." / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Vara, J."' showing total 87 results

Start Over Author "Vara, J." Database OpenAIRE

87 results on '"Vara, J."'

1. Search for correlations of high-energy neutrinos detected in IceCube with radio-bright AGN and gamma-ray emission from blazars

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The IceCube Neutrino Observatory sends realtime neutrino alerts with high probability of being astrophysical in origin. We present a new method to correlate these events and possible candidate sources using $2,089$ blazars from the Fermi-LAT 4LAC-DR2 catalog and with $3,413$ AGNs from the Radio Fundamental Catalog. No statistically significant neutrino emission was found in any of the catalog searches. The result is compatible with a small fraction, $
Published: 2023

2. Measurement of Atmospheric Neutrino Mixing with Improved IceCube DeepCore Calibration and Data Processing

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Mentawi, S. El, Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Experiment
Abstract: We describe a new data sample of IceCube DeepCore and report on the latest measurement of atmospheric neutrino oscillations obtained with data recorded between 2011-2019. The sample includes significant improvements in data calibration, detector simulation, and data processing, and the analysis benefits from a detailed treatment of systematic uncertainties, with significantly higher level of detail since our last study. By measuring the relative fluxes of neutrino flavors as a function of their reconstructed energies and arrival directions we constrain the atmospheric neutrino mixing parameters to be $\sin^2\theta_{23} = 0.51\pm 0.05$ and $\Delta m^2_{32} = 2.41\pm0.07\times 10^{-3}\mathrm{eV}^2$, assuming a normal mass ordering. The resulting 40\% reduction in the error of both parameters with respect to our previous result makes this the most precise measurement of oscillation parameters using atmospheric neutrinos. Our results are also compatible and complementary to those obtained using neutrino beams from accelerators, which are obtained at lower neutrino energies and are subject to different sources of uncertainties.
Published: 2023

3. IceCat-1: the IceCube Event Catalog of Alert Tracks

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Cosmology and Nongalactic Astrophysics (astro-ph.CO), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present a catalog of likely astrophysical neutrino track-like events from the IceCube Neutrino Observatory. IceCube began reporting likely astrophysical neutrinos in 2016 and this system was updated in 2019. The catalog presented here includes events that were reported in real-time since 2019, as well as events identified in archival data samples starting from 2011. We report 275 neutrino events from two selection channels as the first entries in the catalog, the IceCube Event Catalog of Alert Tracks, which will see ongoing extensions with additional alerts. The gold and bronze alert channels respectively provide neutrino candidates with 50\% and 30\% probability of being astrophysical, on average assuming an astrophysical neutrino power law energy spectral index of 2.19. For each neutrino alert, we provide the reconstructed energy, direction, false alarm rate, probability of being astrophysical in origin, and likelihood contours describing the spatial uncertainty in the alert's reconstructed location. We also investigate a directional correlation of these neutrino events with gamma-ray and X-ray catalogs including 4FGL, 3HWC, TeVCat and Swift-BAT., 3 tables, 5 figures. See online version of the catalog on dataverse at https://doi.org/10.7910/DVN/SCRUCD
Published: 2023

4. Search for neutrino lines from dark matter annihilation and decay with IceCube

Author: The IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Aisati, C. El, Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Gustafsson, M., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hambye, T., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Hauser, S., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mari{ş}, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Dark Matter particles in the Galactic Center and halo can annihilate or decay into a pair of neutrinos producing a monochromatic flux of neutrinos. The spectral feature of this signal is unique and it is not expected from any astrophysical production mechanism. Its observation would constitute a dark matter smoking gun signal. We performed the first dedicated search with a neutrino telescope for such signal, by looking at both the angular and energy information of the neutrino events. To this end, a total of five years of IceCube's DeepCore data has been used to test dark matter masses ranging from 10~GeV to 40~TeV. No significant neutrino excess was found and upper limits on the annihilation cross section, as well as lower limits on the dark matter lifetime, were set. The limits reached are of the order of $10^{-24}$~cm$^3/s$ for an annihilation and up to $10^{27}$ seconds for decaying Dark Matter. Using the same data sample we also derive limits for dark matter annihilation or decay into a pair of Standard Model charged particles.
Published: 2023

5. Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. B., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. L., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O’Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Prado Rodriguez, M., Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sanchez Herrera, S. E., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: FOS: Physical sciences, burst [gamma ray], gamma ray: burst, GLAST, High Energy Physics - Experiment, IceCube, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), emission, TeV, ddc:530, Cherenkov, LHAASO, High Energy Astrophysical Phenomena (astro-ph.HE), background, Physics, Astronomy and Astrophysics, redshift, neutrino: UHE, UHE [neutrino], observatory, High Energy Physics - Phenomenology, Cherenkov counter, Space and Planetary Science, correlation, ddc:520, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The astrophysical journal / 2 946(1), L26 (2023). doi:10.3847/2041-8213/acc077, Gamma-ray bursts (GRBs) have long been considered a possible source of high-energy neutrinos. While no correlations have yet been detected between high-energy neutrinos and GRBs, the recent observation of GRB 221009A—the brightest GRB observed by Fermi-GBM to date and the first one to be observed above an energy of 10 TeV—provides a unique opportunity to test for hadronic emission. In this paper, we leverage the wide energy range of the IceCube Neutrino Observatory to search for neutrinos from GRB 221009A. We find no significant deviation from background expectation across event samples ranging from MeV to PeV energies, placing stringent upper limits on the neutrino emission from this source., Published by Institute of Physics Publ., London
Published: 2023
Full Text: View/download PDF

6. Observation of Seasonal Variations of the Flux of High-Energy Atmospheric Neutrinos with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Hauser, S., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Atmospheric muon neutrinos are produced by meson decays in cosmic-ray-induced air showers. The flux depends on meteorological quantities such as the air temperature, which affects the density of air. Competition between decay and re-interaction of those mesons in the first particle production generations gives rise to a higher neutrino flux when the air density in the stratosphere is lower, corresponding to a higher temperature. A measurement of a temperature dependence of the atmospheric $\nu_{\mu}$ flux provides a novel method for constraining hadro\-nic interaction models of air showers. It is particularly sensitive to the production of kaons. Studying this temperature dependence for the first time requires a large sample of high-energy neutrinos as well as a detailed understanding of atmospheric properties. We report the significant ($> 10 \sigma$) observation of a correlation between the rate of more than 260,000 neutrinos, detected by IceCube between 2012 and 2018, and atmospheric temperatures of the stratosphere, measured by the Atmospheric Infrared Sounder (AIRS) instrument aboard NASA's AQUA satellite. For the observed 10$\%$ seasonal change of effective atmospheric temperature we measure a 3.5(3)$\%$ change in the muon neutrino flux. This observed correlation deviates by about 2-3 standard deviations from the expected correlation of 4.3$\%$ as obtained from theoretical predictions under the assumption of various hadronic interaction models, Comment: Preprint submitted to EPJC
Published: 2023
Full Text: View/download PDF

7. D-Egg: a dual PMT optical module for IceCube

Author: Abbasi, R., Ackermann, Markus, Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, Jr. A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., Balagopal V., A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, Marek, Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, Anil, Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Meures, T., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Sandstrom, P., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Shimizu, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sulanke, K. H., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weber, J., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wisher, I., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: visible and IR photons, data acquisition, tube, emission: spectrum, ice, pole, FOS: Physical sciences, costs, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), optical [detector], IceCube: upgrade, Detectors for UV, visible and IR photons, Cherenkov, ddc:610, Neutrino detectors, detector: optical, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Detectors for UV, Mathematical Physics, glass, photomultiplier, spectrum [emission], Cherenkov detectors, sensitivity, production [mass], analog-to-digital converter, efficiency, upgrade [IceCube], mass: production, Astrophysics - Instrumentation and Methods for Astrophysics, performance, photoelectron
Abstract: Journal of Instrumentation 18(04), P04014 (2023). doi:10.1088/1748-0221/18/04/P04014, The D-Egg, an acronym for “Dual optical sensors in anEllipsoid Glass for Gen2,” is one of the optical modules designedfor future extensions of the IceCube experiment at the South Pole.The D-Egg has an elongated-sphere shape to maximize thephoton-sensitive effective area while maintaining a narrow diameterto reduce the cost and the time needed for drilling of thedeployment holes in the glacial ice for the optical modules atdepths up to 2700 m.The D-Egg design is utilized for the IceCube Upgrade, the next stageof the IceCube project also known as IceCube-Gen2 Phase 1, wherenearly half of the optical sensors to be deployed are D-Eggs. Withtwo 8-inch high-quantum efficiency photomultiplier tubes (PMTs) permodule, D-Eggs offer an increased effective area while retaining thesuccessful design of the IceCube digital optical module (DOM). Theconvolution of the wavelength-dependent effective area and theCherenkov emission spectrum provides an effective photodetectionsensitivity that is 2.8 times larger than that of IceCube DOMs. Thesignal of each of the two PMTs is digitized using ultra-low-power14-bit analog-to-digital converters with a sampling frequency of240 MSPS, enabling a flexible event triggering, as well as seamlessand lossless event recording of single-photon signals tomulti-photons exceeding 200 photoelectrons within 10 ns. Massproduction of D-Eggs has been completed, with 277 out of the310 D-Eggs produced to be used in the IceCube Upgrade. Inthis paper, we report the design of the D-Eggs, as well as thesensitivity and the single to multi-photon detection performance ofmass-produced D-Eggs measured in a laboratory using the built-indata acquisition system in each D-Egg optical sensor module., Published by Inst. of Physics, London
Published: 2023
Full Text: View/download PDF

8. Constraining High-energy Neutrino Emission from Supernovae with IceCube

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O’Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O’Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Prado Rodriguez, M., Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sanchez Herrera, S. E., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: Physics, ddc:530
Abstract: Core-collapse supernovae are a promising potential high-energy neutrino source class. We test for correlation between seven years of IceCube neutrino data and a catalog containing more than 1000 core-collapse supernovae of types IIn and IIP and a sample of stripped-envelope supernovae. We search both for neutrino emission from individual supernovae, and for combined emission from the whole supernova sample through a stacking analysis. No significant spatial or temporal correlation of neutrinos with the cataloged supernovae was found. The overall deviation of all tested scenarios from the background expectation yields a p-value of 93% which is fully compatible with background. The derived upper limits on the total energy emitted in neutrinos are 1.7×10$^{48}$ erg for stripped-envelope supernovae, 2.8×10$^{48}$ erg for type IIP, and 1.3×10$^{49}$ erg for type IIn SNe, the latter disfavouring models with optimistic assumptions for neutrino production in interacting supernovae. We conclude that strippe-envelope supernovae and supernovae of type IIn do not contribute more than 14.6% and 33.9% respectively to the diffuse neutrino flux in the energy range of about 10$^3$−10$^5$ GeV, assuming that the neutrino energy spectrum follows a power-law with an index of −2.5. Under the same assumption, we can only constrain the contribution of type IIP SNe to no more than 59.9%. Thus core-collapse supernovae of types IIn and stripped-envelope supernovae can both be ruled out as the dominant source of the diffuse neutrino flux under the given assumptions.
Published: 2023
Full Text: View/download PDF

9. A Search for IceCube sub-TeV Neutrinos Correlated with Gravitational-Wave Events Detected By LIGO/Virgo

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The LIGO/Virgo collaboration published the catalogs GWTC-1, GWTC-2.1 and GWTC-3 containing candidate gravitational-wave (GW) events detected during its runs O1, O2 and O3. These GW events can be possible sites of neutrino emission. In this paper, we present a search for neutrino counterparts of 90 GW candidates using IceCube DeepCore, the low-energy infill array of the IceCube Neutrino Observatory. The search is conducted using an unbinned maximum likelihood method, within a time window of 1000 s and uses the spatial and timing information from the GW events. The neutrinos used for the search have energies ranging from a few GeV to several tens of TeV. We do not find any significant emission of neutrinos, and place upper limits on the flux and the isotropic-equivalent energy emitted in low-energy neutrinos. We also conduct a binomial test to search for source populations potentially contributing to neutrino emission. We report a non-detection of a significant neutrino-source population with this test., Comment: Submitted to ApJ
Published: 2023
Full Text: View/download PDF

10. Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., Balagopal V., A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez de los Heros, C., Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: background, gamma ray: burst, redshift, GLAST, neutrino: UHE, IceCube, observatory, Cherenkov counter, correlation, emission, TeV, Cherenkov, LHAASO
Abstract: Gamma-ray bursts (GRBs) have long been considered a possible source of high-energy neutrinos. While no correlations have yet been detected between high-energy neutrinos and GRBs, the recent observation of GRB 221009A—the brightest GRB observed by Fermi-GBM to date and the first one to be observed above an energy of 10 TeV—provides a unique opportunity to test for hadronic emission. In this paper, we leverage the wide energy range of the IceCube Neutrino Observatory to search for neutrinos from GRB 221009A. We find no significant deviation from background expectation across event samples ranging from MeV to PeV energies, placing stringent upper limits on the neutrino emission from this source.
Published: 2023
Full Text: View/download PDF

11. Constraining High-Energy Neutrino Emission from Supernovae with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., Balagopal, V. A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, Anil, Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: energy: emission, neutrino: energy spectrum, background, neutrino: particle source, GeV, neutrino: VHE, neutrino: flux, neutrino: UHE, IceCube, neutrino: production, collapse, neutrino: energy, correlation, stacking, supernova, neutrino: luminosity
Abstract: Core-collapse supernovae are a promising potential high-energy neutrino source class. We test for correlation between seven years of IceCube neutrino data and a catalog containing more than 1000 core-collapse supernovae of types IIn and IIP and a sample of stripped-envelope supernovae. We search both for neutrino emission from individual supernovae, and for combined emission from the whole supernova sample through a stacking analysis. No significant spatial or temporal correlation of neutrinos with the cataloged supernovae was found. The overall deviation of all tested scenarios from the background expectation yields a p-value of 93% which is fully compatible with background. The derived upper limits on the total energy emitted in neutrinos are $1.7\times 10^{48}$ erg for stripped-envelope supernovae, $2.8\times 10^{48}$ erg for type IIP, and $1.3\times 10^{49}$ erg for type IIn SNe, the latter disfavouring models with optimistic assumptions for neutrino production in interacting supernovae. We conclude that strippe-envelope supernovae and supernovae of type IIn do not contribute more than $14.6\%$ and $33.9\%$ respectively to the diffuse neutrino flux in the energy range of about $10^3-10^5$ GeV, assuming that the neutrino energy spectrum follows a power-law with an index of $-2.5$. Under the same assumption, we can only constrain the contribution of type IIP SNe to no more than $59.9\%$. Thus core-collapse supernovae of types IIn and stripped-envelope supernovae can both be ruled out as the dominant source of the diffuse neutrino flux under the given assumptions.
Published: 2023
Full Text: View/download PDF

12. Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fritz, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Experiment (hep-ex), Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract: The Galactic plane, harboring a diffuse neutrino flux, is a particularly interesting target to study potential cosmic-ray acceleration sites. Recent gamma-ray observations by HAWC and LHAASO have presented evidence for multiple Galactic sources that exhibit a spatially extended morphology and have energy spectra continuing beyond 100 TeV. A fraction of such emission could be produced by interactions of accelerated hadronic cosmic rays, resulting in an excess of high-energy neutrinos clustered near these regions. Using 10 years of IceCube data comprising track-like events that originate from charged-current muon neutrino interactions, we perform a dedicated search for extended neutrino sources in the Galaxy. We find no evidence for time-integrated neutrino emission from the potential extended sources studied in the Galactic plane. The most significant location, at 2.6$\sigma$ post-trials, is a 1.7$^\circ$ sized region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We provide strong constraints on hadronic emission from several regions in the Galaxy., Comment: 13 pages, 4 figures, 5 tables including an appendix. Submitted to Astrophysical Journal
Published: 2023
Full Text: View/download PDF

13. Searches for Neutrinos from LHAASO ultra-high-energy {\gamma}-ray sources using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chang, Y. L., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Galactic PeVatrons are Galactic sources theorized to accelerate cosmic rays up to PeV in energy. The accelerated cosmic rays are expected to interact hadronically with nearby ambient gas or the interstellar medium, resulting in {\gamma}-rays and neutrinos. Recently, the Large High Altitude Air Shower Observatory (LHAASO) identified 12 {\gamma}-ray sources with emissions above 100 TeV, making them candidates for PeV cosmic-ray accelerators (PeVatrons). While at these high energies the Klein-Nishina effect suppresses exponentially leptonic emission from Galactic sources, evidence for neutrino emission would unequivocally confirm hadronic acceleration. Here, we present the results of a search for neutrinos from these {\gamma}-ray sources and stacking searches testing for excess neutrino emission from all 12 sources as well as their subcatalogs of supernova remnants and pulsar wind nebulae with 11 years of track events from the IceCube Neutrino Observatory. No significant emissions were found. Based on the resulting limits, we place constraints on the fraction of {\gamma}-ray flux originating from the hadronic processes in the Crab Nebula and LHAASOJ2226+6057.
Published: 2022

14. Graph Neural Networks for Low-Energy Event Classification & Reconstruction in IceCube

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alves, Jr A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S., Bai, X., Balagopal V., A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., Benda, S., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, Jürgen, Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, Jakob, Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Cross, R., Dappen, Christian, Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, Hannah, Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, Philipp, Gaisser, T. K., Gallagher, J., Ganster, Erik, Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, Lasse Yannik, Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, Jonas, Henningsen, F., Heuermann, Lars Philipp, Hickford, S., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krupczak, E., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peters, L., Petersen, T. C., Peterson, J., Philippen, Saskia, Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Schaufel, Merlin, Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, Georg, Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Wang, W., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, Christopher, Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: data analysis method, neural network, detector: geometry, Data analysis, ice, pole, GeV, IceCube, Particle identification methods, statistical analysis, neutrino, energy, low, neutrino: atmosphere, surface, cloud, neutrino: supernova, Neutrino detectors, detector: optical, neutrino: energy: low, background, photon, scattering, resolution, detector, geometry, trigger, detector, optical, efficiency, cosmic radiation, atmosphere, Analysis and statistical methods, absorption, on-line
Abstract: IceCube, a cubic-kilometer array of optical sensors built to detect atmospheric and astrophysical neutrinos between 1 GeV and 1 PeV, is deployed 1.45 km to 2.45 km below the surface of the ice sheet at the South Pole. The classification and reconstruction of events from the in-ice detectors play a central role in the analysis of data from IceCube. Reconstructing and classifying events is a challenge due to the irregular detector geometry, inhomogeneous scattering and absorption of light in the ice and, below 100 GeV, the relatively low number of signal photons produced per event. To address this challenge, it is possible to represent IceCube events as point cloud graphs and use a Graph Neural Network (GNN) as the classification and reconstruction method. The GNN is capable of distinguishing neutrino events from cosmic-ray backgrounds, classifying different neutrino event types, and reconstructing the deposited energy, direction and interaction vertex. Based on simulation, we provide a comparison in the 1-100 GeV energy range to the current state-of-the-art maximum likelihood techniques used in current IceCube analyses, including the effects of known systematic uncertainties. For neutrino event classification, the GNN increases the signal efficiency by 18% at a fixed false positive rate (FPR), compared to current IceCube methods. Alternatively, the GNN offers a reduction of the FPR by over a factor 8 (to below half a percent) at a fixed signal efficiency. For the reconstruction of energy, direction, and interaction vertex, the resolution improves by an average of 13%-20% compared to current maximum likelihood techniques in the energy range of 1-30 GeV. The GNN, when run on a GPU, is capable of processing IceCube events at a rate nearly double of the median IceCube trigger rate of 2.7 kHz, which opens the possibility of using low energy neutrinos in online searches for transient events.
Published: 2022
Full Text: View/download PDF

15. Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group

Author: Santos García D, García Roca L, de Deus Fonticoba T, Cores Bartolomé C, Naya Ríos L, Canfield H, Paz González JM, Martínez Miró C, Jesús S, Aguilar M, Pastor P, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Blázquez Estrada M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, de Fábregues O, González Ardura J, Alonso Redondo R, Ordás C, López Díaz L LM, McAfee D, Martinez-Martin P, Mir P, and COPPADIS Study Group
Subjects: impairment, Cognition, Parkinson's disease, constipation, non-motor symptoms
Abstract: Background: Constipation has been linked to cognitive impairment development in Parkinson's disease (PD). Objective: Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods: PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson's Disease Cognitive Rating Scale). Subjects with a score >= 1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as "with constipation". Regression analyses were applied for determining the contribution of constipation in cognitive changes. Results: At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p < 0.0001). No change was observed in cognitive status (PD-CRS total score) neither in controls without constipation (from 100.24 +/- 13.72 to 100.27 +/- 13.68; p = 0.971) and with constipation (from 94.71 +/- 10.96 to 93.93 +/- 13.03; p = 0.615). The PD-CRS total score decreased significantly in PD patients with constipation (from 89.14 +/- 15.36 to 85.97 +/- 18.09; p
Published: 2022

16. Searches for Neutrinos from LHAASO ultra-high-energy γ-ray sources using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, Sofia, Axani, S. N., Bai, X., Balagopal V., A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, Summer, Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, Jannes, Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chang, Y. L., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, Marek, Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, Neha Navnitkumar, Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, Sarah, Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, Jannis David, Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez de los Heros, C., Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, Simeon, Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, Alexander, Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: energy: high, accelerator, air, acceleration, showers, suppression, tracks, UHE, IceCube, observatory, flux, cosmic radiation, stacking, gas, supernova, TeV, galaxy, pulsar
Abstract: Galactic PeVatrons are Galactic sources theorized to accelerate cosmic rays up to PeV in energy. The accelerated cosmic rays are expected to interact hadronically with nearby ambient gas or the interstellar medium, resulting in γ-rays and neutrinos. Recently, the Large High Altitude Air Shower Observatory (LHAASO) identified 12 γ-ray sources with emissions above 100 TeV, making them candidates for PeV cosmic-ray accelerators (PeVatrons). While at these high energies the Klein-Nishina effect suppresses exponentially leptonic emission from Galactic sources, evidence for neutrino emission would unequivocally confirm hadronic acceleration. Here, we present the results of a search for neutrinos from these γ-ray sources and stacking searches testing for excess neutrino emission from all 12 sources as well as their subcatalogs of supernova remnants and pulsar wind nebulae with 11 years of track events from the IceCube Neutrino Observatory. No significant emissions were found. Based on the resulting limits, we place constraints on the fraction of γ-ray flux originating from the hadronic processes in the Crab Nebula and LHAASOJ2226+6057.
Published: 2022
Full Text: View/download PDF

17. Constraints on populations of neutrino sources from searches in the directions of IceCube neutrino alerts

Author: Abbasi, R., Ackermann, Markus, Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, Jr. A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, Sofia, Axani, S. N., Bai, X., Balagopal, V. A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., Benda, S., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, Summer, Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, Jannes, Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, Simone, Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krupczak, E., Kun, E., Kurahashi, N., Lad, Neha Navnitkumar, Gualda, C. Lagunas, Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, Wing Yan, Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, Sarah, Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Mukherjee, T., Naab, Richard, Nagai, R., Naumann, U., Nayerhoda, A., Necker, Jannis David, Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peters, L., Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, Simeon, Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, Christian, Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, Alexander, Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Wang, W., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: observatory, density, neutrino: spectrum, neutrino: energy spectrum, TeV, neutrino: particle source, neutrino: VHE, neutrino: flux, neutrino: UHE, IceCube
Abstract: Beginning in 2016, the IceCube Neutrino Observatory has sent out alerts in real time containing the information of high-energy ($E \gtrsim 100$~TeV) neutrino candidate events with moderate-to-high ($\gtrsim 30$%) probability of astrophysical origin. In this work, we use a recent catalog of such alert events, which, in addition to events announced in real-time, includes events that were identified retroactively, and covers the time period of 2011-2020. We also search for additional, lower-energy, neutrinos from the arrival directions of these IceCube alerts. We show how performing such an analysis can constrain the contribution of rare populations of cosmic neutrino sources to the diffuse astrophysical neutrino flux. After searching for neutrino emission coincident with these alert events on various timescales, we find no significant evidence of either minute-scale or day-scale transient neutrino emission or of steady neutrino emission in the direction of these alert events. This study also shows how numerous a population of neutrino sources has to be to account for the complete astrophysical neutrino flux. Assuming sources have the same luminosity, an $E^{-2.5}$ neutrino spectrum and number densities that follow star-formation rates, the population of sources has to be more numerous than $7\times 10^{-9}~\textrm{Mpc}^{-3}$. This number changes to $3\times 10^{-7}~\textrm{Mpc}^{-3}$ if number densities instead have no cosmic evolution.
Published: 2022
Full Text: View/download PDF

18. Risk of Cognitive Impairment in PD Patients with Visual Hallucinations and Subjective Cognitive Complaints

Author: Garcia D, Fonticoba T, Painceiras M, Rios L, Roca L, Miro C, Canfield H, Jesus S, Pastor P, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Mayordomo V, Nogueira V, Puente V, Garcia-Soto J, Borrue C, Solano B, and Sauco M
Published: 2022

19. D-Egg: a Dual PMT Optical Module for IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, Jr. A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., Balagopal, V. A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Meures, T., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Sandstrom, P., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Shimizu, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weber, J., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wisher, I., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: photomultiplier, data acquisition, tube, emission: spectrum, ice, pole, costs, sensitivity, analog-to-digital converter, efficiency, IceCube: upgrade, mass: production, Cherenkov, detector: optical, performance, photoelectron, glass
Abstract: The D-Egg, an acronym for ``Dual optical sensors in an Ellipsoid Glass for Gen2,'' is one of the optical modules designed for future extensions of the IceCube experiment at the South Pole. The D-Egg has an elongated-sphere shape to maximize the photon-sensitive effective area while maintaining a narrow diameter to reduce the cost and the time needed for drilling of the deployment holes in the glacial ice for the optical modules at depths up to 2700 meters. The D-Egg design is utilized for the IceCube Upgrade, the next stage of the IceCube project also known as IceCube-Gen2 Phase 1, where nearly half of the optical sensors to be deployed are D-Eggs. With two 8-inch high-quantum efficiency photomultiplier tubes (PMTs) per module, D-Eggs offer an increased effective area while retaining the successful design of the IceCube digital optical module (DOM). The convolution of the wavelength-dependent effective area and the Cherenkov emission spectrum provides an effective photodetection sensitivity that is 2.8 times larger than that of IceCube DOMs. The signal of each of the two PMTs is digitized using ultra-low-power 14-bit analog-to-digital converters with a sampling frequency of 240 MSPS, enabling a flexible event triggering, as well as seamless and lossless event recording of single-photon signals to multi-photons exceeding 200 photoelectrons within 10 nanoseconds. Mass production of D-Eggs has been completed, with 277 out of the 310 D-Eggs produced to be used in the IceCube Upgrade. In this paper, we report the des ign of the D-Eggs, as well as the sensitivity and the single to multi-photon detection performance of mass-produced D-Eggs measured in a laboratory using the built-in data acquisition system in each D-Egg optical sensor module.
Published: 2022
Full Text: View/download PDF

20. IceCube search for neutrinos coincident with gravitational wave events from LIGO/Virgo run O3

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Asali, Y., Ashida, Y., Athanasiadou, S., Axani, S., Bai, X., Balagopal V., Aswathi, Baricevic, M., Bartos, I., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., Benda, S., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, Jürgen, Böser, S., Botner, O., Böttcher, Jakob, Bourbeau, E., Bradascio, F., Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S. T., Cowen, D. F., Cross, R., Dappen, Christian, Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, Hannah, Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, Erik, Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Günther, Christoph, Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, Lasse Yannik, Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, Jonas, Henningsen, F., Heuermann, Lars Philipp, Hickford, S., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krupczak, E., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Marie Sainte, W., Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Obertacke Pollmann, A., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez de los Heros, C., Peters, L., Peterson, J., Philippen, Saskia, Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Pries, B., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Rysewyk, Cantu D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sanchez Herrera, S. E., Sandrock, A., Santander, M., Sarkar, S., Satalecka, K., Schaufel, Merlin, Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, Georg, Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Silva Oliveira, A. C., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, A. G., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Wang, W., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, Christopher, Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: observatory, energy: emission, VIRGO, neutrino: energy: high, gravitational radiation, optical, LIGO, neutron star, Bayesian, neutrino: flux, IceCube
Abstract: Using data from the IceCube Neutrino Observatory, we searched for high-energy neutrino emission from the gravitational-wave events detected by advanced LIGO and Virgo detectors during their third observing run. We did a low-latency follow-up on the public candidate events released during the detectors' third observing run and an archival search on the 80 confident events reported in GWTC-2.1 and GWTC-3 catalogs. An extended search was also conducted for neutrino emission on longer timescales from neutron star containing mergers. Follow-up searches on the candidate optical counterpart of GW190521 were also conducted. We used two methods; an unbinned maximum likelihood analysis and a Bayesian analysis using astrophysical priors, both of which were previously used to search for high-energy neutrino emission from gravitational-wave events. No significant neutrino emission was observed by any analysis and upper limits were placed on the time-integrated neutrino flux as well as the total isotropic equivalent energy emitted in high-energy neutrinos.
Published: 2022
Full Text: View/download PDF

21. Search for sub-TeV Neutrino Emission from Novae with IceCube-DeepCore

Author: Abbasi, R., Ackermann, Markus, Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, Jr. A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, Sofia, Axani, S. N., Bai, X., Balagopal, V. A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, Summer, Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, Jannes, Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, Neha Navnitkumar, Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Athanasiadou, S., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, Christian, Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, Alexander, Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: nucleus, binary, acceleration, GeV, neutrino: flux, IceCube, observatory, energy: threshold, neutrino: detector, star, bolometer, gamma ray, correlation, site, optical, TeV, white dwarf: surface, hadron
Abstract: The understanding of novae, the thermonuclear eruptions on the surfaces of white dwarf stars in binaries, has recently undergone a major paradigm shift. Though the bolometric luminosity of novae was long thought to be solely attributed to runaway nuclear burning, recent GeV gamma-ray observations have supported the notion that a significant portion of the luminosity could come from radiative shocks. More recently, observations of novae have lent evidence that these shocks are acceleration sites for hadrons for at least some types of novae. In this scenario, a flux of neutrinos may accompany the observed gamma rays. As the gamma rays from most novae have only been observed up to a few GeV, novae have previously not been considered as targets for neutrino telescopes, which are most sensitive at and above TeV energies. Here, we present the first search for neutrinos from novae with energies between a few GeV and 10 TeV using IceCube-DeepCore, a densely instrumented region of the IceCube Neutrino Observatory with a reduced energy threshold. We search both for a correlation between gamma-ray and neutrino emission as well as between optical and neutrino emission from novae. We find no evidence for neutrino emission from the novae considered in this analysis and set upper limits for all gamma-ray detected novae.
Published: 2022
Full Text: View/download PDF

22. Searches for Neutrinos from LHAASO ultra-high-energy γ-ray sources using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chang, Y. L., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), accelerator, air, FOS: Physical sciences, acceleration, showers, suppression, tracks, UHE, IceCube, observatory, flux, cosmic radiation, stacking, gas, supernova, high [energy], TeV, galaxy, pulsar
Abstract: Galactic PeVatrons are Galactic sources theorized to accelerate cosmic rays up to PeV in energy. The accelerated cosmic rays are expected to interact hadronically with nearby ambient gas or the interstellar medium, resulting in γ-rays and neutrinos. Recently, the Large High Altitude Air Shower Observatory (LHAASO) identified 12 γ-ray sources with emissions above 100 TeV, making them candidates for PeV cosmic-ray accelerators (PeVatrons). While at these high energies the Klein-Nishina effect suppresses exponentially leptonic emission from Galactic sources, evidence for neutrino emission would unequivocally confirm hadronic acceleration. Here, we present the results of a search for neutrinos from these γ-ray sources and stacking searches testing for excess neutrino emission from all 12 sources as well as their subcatalogs of supernova remnants and pulsar wind nebulae with 11 years of track events from the IceCube Neutrino Observatory. No significant emissions were found. Based on the resulting limits, we place constraints on the fraction of γ-ray flux originating from the hadronic processes in the Crab Nebula and LHAASOJ2226+6057.
Published: 2022
Full Text: View/download PDF

23. Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial

Author: Perez-Lopez C, Hernandez-Vara J, Caballol N, Bayes A, Buongiorno M, Lopez-Ariztegui N, Gironell A, Lopez-Sanchez J, Martinez-Castrillo J, Sauco M, Lopez-Manzanares L, Escalante-Arroyo S, Perez-Martinez D, and Rodriguez-Molinero A
Subjects: motor fluctuations, Parkinson's disease, automatic ambulatory monitoring, wearable sensors, therapeutic adjustment
Abstract: Background: For specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations. This task is complex and is usually based on the information provided by the patients themselves, which in most cases is complex and biased. In recent times, different tools have appeared on the market that allow automatic ambulatory monitoring. The MoMoPa-EC clinical trial (NCT04176302) investigates the effect of one of these tools-Sense4Care's STAT-ON-can have on routine clinical practice. In this sub-analysis the agreement between the Hauser diaries and the STAT-ON sensor is analyzed. Methods: Eighty four patients from MoMoPa-EC cohort were included in this sub-analysis. The intraclass correlation coefficient was calculated between the patient diary entries and the sensor data. Results: The intraclass correlation coefficient of both methods was 0.57 (95% CI: 0.3-0.73) for the OFF time (%), 0.48 (95% CI: 0.17-0.68) for the time in ON (%), and 0.65 (95% CI%: 0.44-0.78) for the time with dyskinesias (%). Furthermore, the Spearman correlations with the UPDRS scale have been analyzed for different parameters of the two methods. The maximum correlation found was -0.63 (p < 0.001) between Mean Fluidity (one of the variables offered by the STAT-dON) and factor 1 of the UPDRS. Conclusion: This sub-analysis shows a moderate concordance between the two tools, it is clearly appreciated that the correlation between the different UPDRS indices is better with the STAT-ON than with the Hauser diary.
Published: 2022

24. IceCube search for neutrinos coincident with gravitational wave events from LIGO/Virgo run O3

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Asali, Y., Ashida, Y., Athanasiadou, S., Axani, S., Bai, X., Balagopal V., A., Baricevic, M., Bartos, I., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Tjus, J. Becker, Beise, J., Bellenghi, C., Benda, S., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S. T., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., De Vries, K. D., De Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krupczak, E., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Márka, S., Márka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O’Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., De Los Heros, C. Pérez, Peters, L., Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Pries, B., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sanchez Herrera, S. E., Sandrock, A., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva Oliveira, A. C., Silva, M., Oliveira, A. C. Silva, Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Sogaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, A. G., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., Van Eijndhoven, N., Vannerom, D., Van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Wang, W., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: HIGH-ENERGY NEUTRINOS, neutrino: energy: high, FOS: Physical sciences, Astronomy & Astrophysics, Bayesian, neutrino: flux, IceCube, Subatomär fysik, Astronomi, astrofysik och kosmologi, Subatomic Physics, optical, Astronomy, Astrophysics and Cosmology, ddc:530, energy: high [neutrino], LIGO, neutron star, High Energy Astrophysical Phenomena (astro-ph.HE), Science & Technology, ANTARES, energy: emission, emission [energy], Physics, gravitational radiation, TRANSIENTS, Astronomy and Astrophysics, flux [neutrino], FRAMEWORK, observatory, STAR MERGER GW170817, VIRGO, Space and Planetary Science, Physical Sciences, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, FOLLOW-UP
Abstract: The astrophysical journal / 1 944(1), 80 (2023). doi:10.3847/1538-4357/aca5fc, Using data from the IceCube Neutrino Observatory, we searched for high-energy neutrino emission from the gravitational-wave events detected by the advanced LIGO and Virgo detectors during their third observing run. We did a low-latency follow-up on the public candidate events released during the detectors’ third observing run and an archival search on the 80 confident events reported in the GWTC-2.1 and GWTC-3 catalogs. An extended search was also conducted for neutrino emission on longer timescales from neutron star containing mergers. Follow-up searches on the candidate optical counterpart of GW190521 were also conducted. We used two methods; an unbinned maximum likelihood analysis and a Bayesian analysis using astrophysical priors, both of which were previously used to search for high-energy neutrino emission from gravitational-wave events. No significant neutrino emission was observed by any analysis, and upper limits were placed on the time-integrated neutrino flux as well as the total isotropic equivalent energy emitted in high-energy neutrinos., Published by Institute of Physics Publ., London
Published: 2022
Full Text: View/download PDF

25. A Search for Coincident Neutrino Emission from Fast Radio Bursts with Seven Years of IceCube Cascade Events

Author: Abbasi, R., Ackermann, Markus, Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, Jr. A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, Sofia, Axani, S. N., Bai, X., Balagopal, V. A., Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, Summer, Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, Jannes, Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, Simone, Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, Neha Navnitkumar, Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard DeHolton, K., Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, Wing Yan, Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, Sarah, Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, Richard, Nagai, R., Naumann, U., Nayerhoda, A., Necker, Jannis David, Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., de los Heros, C. Pérez, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, Clemens, Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, Simeon, Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, Christian, Stamatikos, M., Stanev, T., Stein, Robert, Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, Alexander, Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., and IceCube Collaboration
Subjects: observatory, radio wave, background: low, galaxy, tracks, burst, neutrino: flux, neutrino: UHE, IceCube, cascade
Abstract: This paper presents the results of a search for neutrinos that are spatially and temporally coincident with 22 unique, non-repeating Fast Radio Bursts (FRBs) and one repeating FRB (FRB121102). FRBs are a rapidly growing class of Galactic and extragalactic astrophysical objects that are considered a potential source of high-energy neutrinos. The IceCube Neutrino Observatory's previous FRB analyses have solely used track events. This search utilizes seven years of IceCube's cascade events which are statistically independent of the track events. This event selection allows probing of a longer range of extended timescales due to the low background rate. No statistically significant clustering of neutrinos was observed. Upper limits are set on the time-integrated neutrino flux emitted by FRBs for a range of extended time-windows.
Published: 2022
Full Text: View/download PDF

26. Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up

Author: Garcia D, Rios L, Fonticoba T, Bartolome C, Roca L, Painceiras M, Miro C, Canfield H, Jesus S, Aguilar M, Pastor P, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Mayordomo V, Nogueira V, Puente V, Dotor J, Borrue C, Vila B, Sauco M, Vela L, Escalante S, Cubo E, Padilla F, Castrillo J, Alonso P, Losada M, Ariztegui N, Gaston I, Kulisevsky J, Estrada M, Seijo M, Martinez J, Valero C, Kurtis M, de Fabregues O, Ardura J, Redondo R, Ordas C, Diaz L, McAfee D, Martinez-Martin P, Mir P, COPPADIS Study Grp, Instituto de Salud Carlos III, Takeda Pharmaceutical Company, International Parkinson and Movement Disorder Society, AbbVie Pharmaceuticals, Abbott Laboratories, Allergan Foundation, BIAL Foundation, Merz Pharma, UCB Pharma, Zambon, Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía, Sociedad Andaluza de Neurología, Jacques and Gloria Gossweiler Foundation, Fundación Alicia Koplowitz, Fundación Mutua Madrileña, Institut Català de la Salut, [Santos-García D, Naya Rios L, Cores Bartolomé C, García Roca L, Feal Painceiras M, Martínez Miró C] Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. [de Deus Fonticoba T, Canfield H] Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Aguilar M, Pastor P] Hospital Universitari Mutua de Terrassa, Terrassa , Spain. [Cosgaya M] Hospital Clínic de Barcelona, Barcelona, Spain. [García-Caldentey J] Centro Neurológico Oms, Palma de Mallorca, Spain. [Caballol N] Consorci Sanitari Integral, Hospital Moisés Broggi, Barcelona, Spain. [Legarda I] Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Hernández-Vara J, de Fábregues O] Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Cabo López I, Seijo M] Complexo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. [López Manzanares L] Hospital Universitario La Princesa, Madrid, Spain. [González Aramburu I] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Ávila Rivera MA] Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez-Mayordomo V] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Nogueira V] Hospital Da Costa, Burela, Lugo, Spain. [Puente V] Hospital del Mar, Barcelona, Spain. [Dotor J] Hospital Universitario Virgen Macarena, Sevilla, Spain. [Borrué C] Hospital Infanta Sofía, Madrid, Spain. [Solano Vila B] Institut d'Assistència Sanitària (IAS), Institut Català de la Salut (ICS), Salt, Spain. [Álvarez Sauco M] Hospital General Universitario de Elche, Elche, Spain. [Vela-Desojo L] Fundación Hospital de Alcorcón, Madrid, Spain. [Escalante S] Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Spain. [Cubo E] Complejo Asistencial Universitario de Burgos, Burgos, Spain. [Carrillo-Padilla F] Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Martínez Castrillo JC] Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. [Sánchez Alonso P] Hospital Universitario Puerta de Hierro, Madrid, Spain. [Alonso Losada MG] Hospital Álvaro Cunqueiro, Complexo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. [López-Ariztegui N] Complejo Hospitalario de Toledo, Toledo, Spain. [Gastón I] Complejo Hospitalario de Navarra, Pamplona, Spain. [Kulisevsky J] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital de Sant Pau, Barcelona, Spain. [Blázquez Estrada M] Hospital Universitario Central de Asturias, Oviedo, Spain. [Ruiz-Martínez J] Hospital Universitario Donostia, San Sebastián, Spain. [Valero C] Hospital Arnau de Vilanova, València, Spain. [Kurtis M] Hospital Ruber Internacional, Madrid, Spain. [González Ardura J] Hospital de Cabueñes, Gijón, Spain. [Alonso Redondo R] Universitario Lucus Augusti (HULA), Lugo, Spain. [Ordás C] Hospital Rey Juan Carlos, Madrid, Spain. [López Díaz LM] Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain. [McAfee D] University of Maryland School of Medicine, Baltimore, USA. [Martinez-Martin P] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, and Institut d'Assistència Sanitària
Subjects: enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::trastornos del movimiento::trastornos parkinsonianos::enfermedades del sistema nervioso::enfermedad de Parkinson [ENFERMEDADES], Medicine (General), changes, motor, Parkinson’s disease, phenotype, PIGD, Tremor, endocrine system diseases, genetic structures, Parkinson's disease, Clinical Biochemistry, Tremolor, Nervous System Diseases::Central Nervous System Diseases::Nervous System Diseases::Central Nervous System Diseases::Movement Disorders::Parkinsonian Disorders::Nervous System Diseases::Parkinson Disease [DISEASES], enfermedades del sistema nervioso::manifestaciones neurológicas::discinesias::temblor [ENFERMEDADES], Article, eye diseases, Fenotip, R5-920, Genetic Phenomena::Phenotype [PHENOMENA AND PROCESSES], Parkinson, Malaltia de, fenómenos genéticos::fenotipo [FENÓMENOS Y PROCESOS], Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Tremor [DISEASES]
Abstract: [Background and objective] Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it., [Patients and Methods] PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls., [Results] The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716)., [Conclusions] Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity., Martínez-Martin P. has received honoraria from National School of Public Health (ISCIII), Editori-al Viguera and Takeda Pharmaceuticals for lecturing in courses, and from the International Parkinson and Movement Disorder Society (MDS) for management of the Program on Rating Scales. Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB, and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575], co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [ PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.
Published: 2021

27. Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Author: Rodriguez-Molinero, A, Hernandez-Vara, J, Minarro, A, Perez-Lopez, C, Bayes-Rusinol, A, Martinez-Castrillo, JC, Perez-Martinez, DA, Gironell, A, and Monitoring Parkinsons Patients Mob
Abstract: Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson's Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson's Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor-patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.
Published: 2021

28. Predictors of clinically significant quality of life impairment in Parkinson's disease

Author: Garcia D, Fonticoba T, Cores C, Munoz G, Gonzalez J, Miro C, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Catalan M, Nogueira V, Puente V, de Arcos M, Borrue C, Vila B, Sauco M, Vela L, Escalante S, Cubo E, Padilla F, Castrillo J, Alonso P, Losada M, Ariztegui N, Gaston I, Clavero P, Kulisevsky J, Estrada M, Seijo M, Martinez J, Valero C, Kurtis M, de Fabregues O, Ardura J, Ordas C, Diaz L, McAfee D, Martinez-Martin P, Mir P, and COPPADIS Study Grp
Abstract: Quality of life (QOL) plays an important role in independent living in Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months +/- 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 >= 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 +/- 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 +/- 13 to 20.3 +/- 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829-0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422-12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053-1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027-1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer-Lemeshow test, p = 0.665; R-2 = 0.655). An increase in >= 5 and >= 10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663-17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975-22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.
Published: 2021

29. Mood in Parkinson's disease: From early- to late-stage disease

Author: Ángel Aneiros, Ardura J. González, Nuria Caballol, Jurczynska C. Prieto, C Valero, Víctor Nogueira, Silvia Jesús, Pablo Mir, Lluís Planellas, Padilla F. Carrillo, Caldente J. García, I. Legarda, Losada M. G. Alonso, Itziar Gastón, Moreno J. M. García, Miquel Aguilar, Aymerich L. Valdés, Alonso P. Sánchez, Bartolome C. Cores, Vila B. Solano, Darrian McAfee, Lydia Vela, Aramburu I. González, Pau Pastor, Esther Cubo, Castro E. Suárez, Víctor Puente, Ariztegui N. López, Díaz L. López, Castrillo J. C. Martínez, Fonticoba T. De Deus, Diego Santos-García, Rivera M. A. Ávila, Jaime Kulisevsky, C Borrué, Monica M. Kurtis, S Escalante, Vara J. Hernández, Sauco M. Álvarez, Marina Cosgaya, Manzanares L. López, M Seijo, Iria Cabo, Estrada M. Blázquez, Catalán M. José, Martínez J. Rúiz, and Oriol de Fábregues-Boixar
Subjects: Male, medicine.medical_specialty, Parkinson's disease, mood, Disease, Group B, s disease, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Surveys and Questionnaires, Linear regression, Medicine, Humans, Depression (differential diagnoses), Aged, 030214 geriatrics, business.industry, Parkinson Disease, Parkinson&apos, medicine.disease, Health Surveys, Psychiatry and Mental health, Mood, Cross-Sectional Studies, quality of life, Cohort, depression, Quality of Life, Female, Geriatrics and Gerontology, disease duration, business
Abstract: Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: = 10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). Results Six hundred and sixty-three PD patients (62.6 +/- 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.
Published: 2021

30. Insights from agreements on migration between the EU and Turkey

Author: Groenendijk, C.A., Carrera, S., Santos Vara, J., Strik, M.H.A., Carrera, S., Santos Vara, J., and Strik, M.H.A.
Subjects: Centre for Migration Law, Centrum voor Migratierecht
Abstract: Item does not contain fulltext
Published: 2019

31. Variability of diagnostic criteria and treatment of idiopathic nephrotic syndrome across European countries

Author: Deschênes, G., Vivarelli, M., Peruzzi, L., Alpay, H., Alvaro Madrid, A., Andersen, R., Bald, M., Benetti, E., Berard, E., Bockenhauer, D., Boyer, O., Brackman, D., Dossier, C., Ekinci, Z., Emma, F., Enneman, B., Espinosa Roman, L., Fila, M., Ghio, L., Groothoff, J., Guigonis, V., Jankauskiene, A., Kagan, M., Kovacevic, M., Kemper, M., Levtchenko, E., Maringhini, S., Mir, S., Mitsioni, A., Mizerska Wasiak, M., Wasiak, K., Moczulska, A., Montini, G., Murer, L., Nuutinen, M., Obukhova, V., Oh, J., Ozkaya, O., Papalia, T., Peco Antic, A., Pecoraro, C., Pena Carrion, A., Petrossian, E., Pietrement, C., Prikhodina, L., Querfeld, U., Rittig, S., Saleem, M., Saraga, M., Savenkova, N., Sever, L., Tullus, K., Ulinski, T., Vande Walle, J., Vara, J., Webb, N., Weber, L., Zurowska, A., ARD - Amsterdam Reproduction and Development, Paediatric Nephrology, APH - Quality of Care, APH - Methodology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: Pediatrics, medicine.medical_specialty, Nephrotic Syndrome, 030232 urology & nephrology, MEDLINE, Disease, Guidelines, Steroid dependency, Idiopathic Nephrotic Syndrome, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Prednisone, Recurrence, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Child, Glucocorticoids, Proteinuria, Rituximab, Steroid resistance, Settore MED/38 - Pediatria Generale e Specialistica, business.industry, Europe, Treatment Outcome, Pediatrics, Perinatology and Child Health, Immunology, Disease Progression, Drug Therapy, Combination, business, Immunosuppressive Agents, medicine.drug
Abstract: The aim of the surveys conducted by the Idiopathic Nephrotic Syndrome Working Group of the ESPN was to study the possible variability of treatment in Europe at different stages of the disease by means of questionnaires sent to members of the Working Group. Four surveys have been completed: treatment of the first flare, treatment of the first relapse and the issue of steroid dependency, use of rituximab, and the management of steroid-resistant patients. A uniform treatment of the first flare was applied in only three countries, and ten additional centers have adopted one of the three main protocols. Reported treatment of the first relapse was relatively uniform, whereas the use of additional immunosuppressants in steroid dependency was widely variable. Rituximab had already been used in hundreds of patients, although the formal evidence of efficiency in steroid dependency was relatively recent at the time of the survey. The definition of steroid resistance was variable in the European centers, but strikingly, the first-line treatment was uniform throughout the centers and included the combination of prednisone plus calcineurin antagonists. The variability in the approach of idiopathic nephrotic syndrome is unexpectedly large and affects treatment of the first flare, strategies in the case of steroid dependency, as well as the definitions of steroid resistance. What is Known: • Steroids and immunosuppressants are the universal treatment of idiopathic nephrotic syndrome. What is New: • The variability of treatments and strategy of treatment in European centers of pediatric nephrology
Published: 2017
Full Text: View/download PDF

32. alpha-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease

Author: Garrido, A, Fairfoul, G, Tolosa, ES, Marti, MJ, Green, A, Compta, Y, Valldeoriola, F, Munoz, E, Fernandez, M, Alvarez, R, Vilas, D, Ispierto, L, De Fabregues, O, Hernandez-Vara, J, Puente, V, Calopa, M, Jauma, S, Campdelacreu, J, Bayes, A, Avila, A, Caballol, N, Aguilar, M, and Casquero, P
Abstract: Background Leucine-rich kinase 2 (LRRK2)-linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy-type synucleinopathy as its principal histological substrate. To date no in vivo biomarkers of synucleinopathy have been found in LRRK2 mutation carriers. Objectives We used real-time quaking-induced conversion (RT-QuIC) technique to assess the presence of alpha-synuclein (a-syn) aggregates in cerebrospinal fluid (CSF) of LRRK2 p.G2019S carriers. Methods CSF samples of 51 subjects were analyzed: 15 LRRK2 p.G2019S PD, 10 IPD, 16 LRRK2 p.G2019S nonmanifesting carriers (NMC) and 10 healthy controls. The presence of parkinsonism and prodromal symptoms was assessed in all study subjects. Results Forty percent (n = 6) LRRK2-PD, and 18.8% (n = 3) LRRK2-NMC had a positive a-syn RT-QuIC response. RT-QuIC detected IPD with 90% sensitivity and 80% specificity. No clinical differences were detected between LRRK2-PD patients with positive and negative RT-QuIC. A positive RT-QuIC result in LRRK2-NMC occurred in a higher proportion of subjects meeting the Movement Disorder Society research criteria for prodromal PD. Interpretation RT-QuIC detects a-syn aggregation in CSF in a significant number of patients with LRRK2-PD, but less frequently than in IPD. A small percentage of LRRK2-NMC tested also positive. If appropriately validated in long-term studies with large number of mutation carriers, and hopefully, postmortem or in vivo confirmation of histopathology, RT-QuIC could contribute to the selection of candidates to receive disease modifying drugs, in particular treatments targeting a-syn deposition.
Published: 2019

33. Transformation or continuity? EU external migration policy in the aftermath of the ‘migration crisis’

Author: Reslow, Natasja, Carrera, S., Santos Vara, J., Strik, T., International and European Law, RS: FdR - CERiM, RS: FDR - MACIMIDE, RS: FdR Institute MCEL, and RS: FdR IC Integratie
Subjects: geography, Politics, Summit, geography.geographical_feature_category, Empirical research, Member states, General partnership, Political science, Political economy, Public policy, External migration, Document analysis
Abstract: In 2015, 1.3 million people filed asylum applications in one of the EU28 Member States. This enormous increase in migration inflows shook Europe and led to extraordinary scenes at the EU’s borders, intense political conflict both within and between the EU Member States and EU institutions, and far-reaching public debates on how to respond. The challenges posed by the ‘migration crisis’ can be seen as a type of critical juncture, which raises the question of where EU migration and asylum policies go from here. This chapter contributes to the fledgling academic literature on the ‘crisis’ by examining its effect on the content and form of EU external migration policy. The paper asks: to what extent has EU external migration policy changed since 2015? First an analytical framework for assessing ‘policy change’ is derived from the public policy literature. This framework is then applied, through a document analysis, to the main externalised policy responses to the ‘migration crisis’: the European Agenda on Migration; the Valletta summit; the EU-Turkey Statement; and the Migration Partnership Framework. The analysis thus reveals the extent to which EU external migration policy has changed over the past 2 years, how this change has played out, and the relationship between policy change and the ‘migration crisis’. The conclusion outlines theoretical explanations for policy change and policy stability, to be put to an empirical test in future research.
Published: 2019

34. COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015): an ongoing global Parkinson's disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation

Author: Garcia, D, Jesus, S, Aguilar, M, Planellas, L, Caldentey, J, Caballol, N, Legarda, I, Vara, J, Cabo, I, Manzanares, L, Aramburu, I, Rivera, M, Catalan, M, Diaz, L, Puente, V, Moreno, J, Borrue, C, Vila, B, Sauco, M, Vela, L, Escalante, S, Cubo, E, Padilla, F, Castrillo, J, Alonso, P, Losada, M, Ariztegui, N, Gaston, I, Kulisevsky, J, Gonzalez, M, Seijo, M, Martinez, J, Valero, C, Kurtis, M, de Fabregues-Boixar, O, Ardura, J, Jurczynska, C, Martinez-Martin, P, Mir, P, Astrid, D, Almeria, M, Canovas, A, Frech, F, Diaz, A, Arnaiz, S, Arribas, S, Vidondo, A, Lambrich, N, Bejr-Kasem, H, Estrada, M, Boti, M, Gonzalez, C, Lorenzo, A, Carrillo, F, Casas, E, Clavero, P, Fernandez, A, Foraster, A, Cuevas, A, Fonticoba, T, Diez-Fairen, M, Erro, E, Peyret, E, Guillan, N, Gamez, P, Gallego, M, Campos, C, Garre, M, Aloy, J, Garcia, B, Palmas, M, Toledo, G, Sola, M, Guardia, G, Horta-Barba, A, Infante, J, Labandeira, C, Labrador, M, Lacruz, F, Castro, M, Seoane, B, Macias, Y, Mata, M, Andres, G, Marti, M, McAfee, D, Meitin, M, del Barrio, C, Santiago, J, Casado, M, Dieguez, A, Nogueira, V, Amado, A, Ponte, S, Ordas, C, Pagonabarraga, J, Parees, I, Pascual-Sedano, B, Pastor, P, Fuertes, A, Noguera, R, Prats, M, Morlans, M, Rafales, N, Mendez, L, Perez, A, Roldan, F, De Arcos, M, Sanchez-Carpintero, M, Diez, G, Rodriguez, A, Santacruz, P, Rodriguez, J, Serarols, A, Pena, M, Castro, E, Tartari, J, Vargas, L, Gomez, R, Villanueva, C, Vives, B, Villar, M, and COPPADIS Study Grp
Subjects: motor fluctuations, quality of life, mood, Parkinson's disease, gait, non-motor symptoms
Abstract: Background and purpose In Parkinson's disease (PD), the course of the disorder is highly variable between patients. Well-designed, prospective studies for identifying PD progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global PD project, COPPADIS-2015 (Cohort of Patients with PArkinson's DIsease in Spain, 2015). Methods This was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October 2017. Baseline evaluation included more than 15 validated scales and complementary studies in a subgroup of participants. Results In total, 1174 subjects from 35 centres were considered valid for baseline analysis: 694 patients (62.6 +/- 8.9 years old, 60.3% males), 273 caregivers (58.5 +/- 11.9 years old, 31.8% males) and 207 controls (61 +/- 8.3 years old, 49.5% males). The mean disease duration was 5.5 +/- 4.4 years. Hoehn and Yahr stage was 1 or 2 in 90.7% of the patients whilst 33.9% and 18.1% of them presented motor fluctuations and dyskinesias, respectively. The mean Non-Motor Symptoms Scale total score was 45.4 +/- 38.1, and 30.4% of the patients presented cognitive impairment, 16.1% major depression, 12.7% impulse control disorder, 7.2% compulsive behaviour, 57.2% pain and 13.2% falls. Compared to the control group, PD patients presented a significantly higher burden of non-motor symptoms and a worse quality of life. More than 300 subjects conducted complementary studies (serum biomarkers, genetic and neuroimaging). Conclusions Parkinson's disease is a complex disorder and different non-motor symptoms are frequently present and are more prevalent than in controls. In real clinical practice it is important to ask for them.
Published: 2019

35. Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort

Author: Garcia, D, Fonticoba, T, Castro, E, Borrue, C, Mata, M, Vila, B, Foraster, A, Sauco, M, Perez, A, Vela, L, Macias, Y, Escalante, S, Esteve, P, Villarroya, S, Cubo, E, Casas, E, Arnaiz, S, Padilla, F, Morlans, M, Mir, P, Martinez-Martin, P, Adarmes, A, Almeria, M, Losada, G, Canovas, A, Alonso-Frech, F, Arribas, S, Vidondo, A, Aguilar, M, Avila, M, Lambrich, N, Bejr-Kasem, H, Estrada, M, Boti, M, Gonzalez, C, Lopez, I, Caballol, N, Lorenzo, A, Carrillo, F, Catalan, M, Clavero, P, Fernandez, A, Cuevas, A, de Fabregues-Boixar, O, Diez-Fairen, M, Erro, E, Peyret, E, Guinan, N, Gamez, P, Gallego, M, Caldentey, J, Campos, C, Moreno, J, Gaston, I, Garre, M, Aloy, J, Gonzalez-Aramburu, I, Ardura, J, Garcia, B, Palmas, M, Toledo, G, Diaz, A, Sola, M, Guardia, G, Hernandez-Vara, J, Barba, A, Infante, J, Jesus, S, Kulisevsky, J, Kurtis, M, Labandeira, C, Labrador, M, Lacruz, F, Castro, M, Legarda, I, Ariztegui, N, Diaz, L, Manzanares, L, Seoane, B, Andres, G, Marti, M, Martinez-Castrillo, J, McAfee, D, Meitin, M, Gonzalez, M, del Barrio, C, Santiago, J, Casado, M, Dieguez, A, Nogueira, V, Amado, A, Ponte, S, Ordas, C, Pagonabarraga, J, Parees, I, Pascual-Sedano, B, Pastor, P, Fuertes, A, Noguera, R, Planellas, L, Fuster, J, Prats, M, Jurczynska, C, Puente, V, Rafales, N, Mendez, L, Roldan, F, De Arcos, M, Martinez, J, Alonso, P, Sanchez-Carpintero, M, Diez, G, Rodriguez, A, Santacruz, P, Rodriguez, J, Seijo, M, Serarols, A, Pena, M, Tartari, J, Vargas, L, Gomez, R, Villanueva, C, Vives, B, Villar, M, and Coppadis Study Grp
Subjects: Quality of life, Parkinson's disease, Mood, Non-motor symptoms, Gait, humanities, Motor fluctuations
Abstract: Objective: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of nondemented Parkinson's disease (PD) patients and compare to a control group. Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. Results: QoL was worse in PD patients (n = 692; 62.6 +/- 8.9 years old, 60.3% males) than controls (n = 206; 61 +/- 8.3 years old, 49.5% males): PDQ-39, 17.1 +/- 13.5 vs 4.4 +/- 6.3 (p < 0.0001); PQ-10, 7.3 +/- 1.6 vs 8.1 +/- 1.2 (p < 0.0001); EUROHIS-Q0L8, 3.8 +/- 0.6 vs 4.2 +/- 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (beta = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait pro- blems contributed the most to global QoL (PQ-10, beta = -0.46 and -0.21, respectively; EUROHIS-QOL8, beta = - 0.44 and - 0.23, respectively). Conclusions: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.
Published: 2019

36. Jurisdiction

Author: Ryngaert, C., van der Wilt, H., Santos Vara, J., Nollkaemper, A., Reinisch, A., and Strafrecht (FdR)
Published: 2018

37. Long-term response to continuous duodenal infusion of levodopa/carbidopa gel in patients with advanced Parkinson disease: The Barcelona registry

Author: Buongiorno, M, Antonelli, F, Camara, A, Puente, V, de Fabregues-Nebot, O, Hernandez-Vara, J, Calopa, M, Pascual-Sedano, B, Campolongo, A, Valldeoriola, F, Tolosa, E, Kulisevsky, J, and Marti, MJ
Subjects: Parkinson disease, Levodopa/carbidopa intestinal gel, Long-term treatment, Non-motor symptoms, Motor fluctuations
Abstract: Introduction: Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. Methods: We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated with LCIG, long-term information about the outcome and safety of the treatment. The assessments were performed before LCIG, 1, 3, 6 months after, and ever since, every 6 months. Results: We studied 72 patients with a mean observation time of 22 months and a maximum of 48 months. During follow-up 28 patients discontinued the treatment, especially for lack of efficacy or adverse events related to the drug. We obtained a significant improvement of motor and non-motor fluctuations, mean off time and some non-motor symptoms. A significant increase in the percentage of time with dyskinesias was found in patients having less than 50% of the day with dyskinesias before LCIG. However, patients having already many dyskinesias before LCIG experienced a significant decrease of the troublesome dyskinesias, meaning that outcomes might be different depending on specific clinical characteristics. Adverse effects were in general minor but one case of intestinal perforation and one of abdominal cellulite were observed. Conclusions: We confirmed that LCIG is a very effective treatment option for advanced PD; however considering the findings that dyskinesia can increase and the potential for serious side effects, we suggest the necessity for development of guidelines that better define the profile of responders. (C) 2015 Elsevier Ltd. All rights reserved.
Published: 2015

38. Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY

Author: Orth M, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho AK, Wild E, Tabrizi SJ, Landwehrmeyer GB, Investigators of the European Huntington's Disease N.e.t.w.o.r.k. CollaboratorsBonelli R, Herranhof B, Hödl A, Koppitz M, Magnet M, Otti D, Painold A, Reisinger K, Flamez A, Morez V, de Raedt S, Ribaï P, Verellen Dumoulin C, Vandenberghe W, van Reijen D, Hasholt L, Hjermind L, Jakobsen O, Nørremølle A, Sørensen S, Stokholm J, Peippo M, Sipponen M, Hiivola H, Martikainen K, Tuuha K, Kosinski C, Probst D, Sass C, Schiefer J, Schlangen C, Werner C, Priller J, Prüss H, Andrich J, Hoffmann R, Kraus P, Prehn C, Saft C, Salmen S, Strassburger K, Lange H, Hunger U, Löhle M, Schmidt S, Storch A, Wolz A, Wolz M, Lammbeck J, Zucker B, Hidding U, Münchau A, Stubbe L, Heinicke W, Longinus B, Möller J, Rissling I, Peinemann A, Städtler M, Weindl A, Bohlen S, Reilmann R, Beister A, Dose M, Leythaeuser G, Marquard R, Schrenk C, Schuierer M, Wiedemann A, Ecker D, Landwehrmeyer B, Lezius F, Trautmann S, Bertini E, Mechi C, Paganini M, Piacentini S, Romoli M, Sorbi S, Abbruzzese G, di Poggio M, Di Maria E, Ferrandes G, Mandich P, Marchese R, Albanese A, Di Donato S, Mariotti C, Soliveri P, Carlo R, Luigi D, Rinaldi C, Tucci T, Ciarmiello A, Martino T, Simonelli M, Squitieri F, Bentivoglio A, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G, Piano C, Romano S, Soleti F, Spadaro M, Zinzi P, Heiberg A, van Walsem M, Bjørgo K, Fannemel M, Lars Retterstøl P, Bjørnevoll I, Sando S, Sitek E, Slawek J, Soltan W, Boczarska Jedynak M, Jasinska Myga B, Opala G, Rudzińska M, Szczudlik A, Wójcik M, Banaszkiewicz K, Bryl A, Ciesielska A, Klimberg A, Kozubski W, Marcinkowski J, Sempołowicz P, Zielonka D, Janik P, Kalbarczyk A, Kwiecinski H, Jamrozik Z, Antczak J, Witkowski G, Rakowicz M, Richter P, Ryglewicz D, Zaremba J, Zdzienicka E, Costa C, Coelho M, Ferreira J, Mestre T, Rosa M, Valadas A, Gago M, Garrett C, Guerra M, Bas J, Calopa M, Barberà M, Badenes D, Casas L, Arroyo S, Vara J, Krupinski J, López J, Obdulia M, Ferrer P, Sebastián A, Contreras S, Carruesco G, Cubo E, Mariscal N, Sánchez J, Barrero F, Morales B, López Sendón Moreno J, García RR, Quiroga P, Villanueva C, Ruíz Espiga PJ, Martínez A, Artiga MS, Sánchez V, Bascuñana M, Fatas M, Ribas G, de Yébenes J, López Moreno J, Schwarz C, Cubillo P, Arques P, Gorospe A, Legarda I, Torres Rodríguez M, Gaston I, Ramos Arroyo MA, Del Val JL, Martinez L, Burgunder JM, Romero I, Schüpbach M, Zaugg SW, van Hout MS, van Vugt JP, de Weert AM, Bolwijn JJ, Dekker M, Leenders KL, van Oostrom JC, Bos R, Dumas E, Jurgens CK, Roos RA, Witjes Ané MN, Matheson K, Rae D, Simpson S, Summers F, Ure A, Curtis A, Keylock J, Rickards H, Wright J, Barker R, Fisher K, Goodman AG, Hill S, Kershaw A, Mason S, Paterson N, Raymond L, Bisson J, Busse M, Ellison Rose L, Handley O, Dunnett S, Naji J, Price K, Rosser A, Edwards M, De Sousa P, Hughes T, McGill M, Pearson P, Porteous M, Zema A, Brockie P, Foster J, Johns N, McKenzie S, Thomas G, Burrows L, Fletcher A, Laver F, Silva M, Thomson A, Chu C, Hobson E, Jamieson S, Toscano J, Wild S, Yardumian P, Bourne C, Clayton C, Dipple H, Grant J, Gross D, Hallam C, Middleton J, Murch A, Andrews T, Dougherty A, Kavalier F, Golding C, Lashwood A, Robertson D, Ruddy D, Whaite A, Bruno S, Henley S, Novak M, O'Driscoll C, Patel A, Rosser E, Tabrizi S, Taylor R, Warner T, Arran N, Fullam R, Howard L, Huson S, Partington Jones L, Ritchie N, Snowden J, Solom A, Stopford C, Thompson J, Westmoreland L, Nemeth A, Siuda G, Bandmann O, Bradbury A, Fillingham K, Foustanos I, Quarrell O, Reynders H, Robertson L, Tidswell K., DE MICHELE, GIUSEPPE, SALVATORE, ELENA, Orth M, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho AK, Wild E, Tabrizi SJ, Landwehrmeyer GB, Investigators of the European Huntington's Disease Network. Collaborators (314), Orth, M, Handley, Oj, Schwenke, C, Dunnett, Sb, Craufurd, D, Ho, Ak, Wild, E, Tabrizi, Sj, Landwehrmeyer, Gb, CollaboratorsBonelli R, Investigators of the European Huntington's Disease N. e. t. w. o. r. k., Herranhof, B, Hödl, A, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Flamez, A, Morez, V, de Raedt, S, Ribaï, P, Verellen Dumoulin, C, Vandenberghe, W, van Reijen, D, Hasholt, L, Hjermind, L, Jakobsen, O, Nørremølle, A, Sørensen, S, Stokholm, J, Peippo, M, Sipponen, M, Hiivola, H, Martikainen, K, Tuuha, K, Kosinski, C, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, C, Priller, J, Prüss, H, Andrich, J, Hoffmann, R, Kraus, P, Prehn, C, Saft, C, Salmen, S, Strassburger, K, Lange, H, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lammbeck, J, Zucker, B, Hidding, U, Münchau, A, Stubbe, L, Heinicke, W, Longinus, B, Möller, J, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bohlen, S, Reilmann, R, Beister, A, Dose, M, Leythaeuser, G, Marquard, R, Schrenk, C, Schuierer, M, Wiedemann, A, Ecker, D, Landwehrmeyer, B, Lezius, F, Trautmann, S, Bertini, E, Mechi, C, Paganini, M, Piacentini, S, Romoli, M, Sorbi, S, Abbruzzese, G, di Poggio, M, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Donato, S, Mariotti, C, Soliveri, P, Carlo, R, Luigi, D, DE MICHELE, Giuseppe, Rinaldi, C, Salvatore, Elena, Tucci, T, Ciarmiello, A, Martino, T, Simonelli, M, Squitieri, F, Bentivoglio, A, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Piano, C, Romano, S, Soleti, F, Spadaro, M, Zinzi, P, Heiberg, A, van Walsem, M, Bjørgo, K, Fannemel, M, Lars Retterstøl, P, Bjørnevoll, I, Sando, S, Sitek, E, Slawek, J, Soltan, W, Boczarska Jedynak, M, Jasinska Myga, B, Opala, G, Rudzińska, M, Szczudlik, A, Wójcik, M, Banaszkiewicz, K, Bryl, A, Ciesielska, A, Klimberg, A, Kozubski, W, Marcinkowski, J, Sempołowicz, P, Zielonka, D, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Witkowski, G, Rakowicz, M, Richter, P, Ryglewicz, D, Zaremba, J, Zdzienicka, E, Costa, C, Coelho, M, Ferreira, J, Mestre, T, Rosa, M, Valadas, A, Gago, M, Garrett, C, Guerra, M, Bas, J, Calopa, M, Barberà, M, Badenes, D, Casas, L, Arroyo, S, Vara, J, Krupinski, J, López, J, Obdulia, M, Ferrer, P, Sebastián, A, Contreras, S, Carruesco, G, Cubo, E, Mariscal, N, Sánchez, J, Barrero, F, Morales, B, López Sendón Moreno, J, García, Rr, Quiroga, P, Villanueva, C, Ruíz Espiga, Pj, Martínez, A, Artiga, M, Sánchez, V, Bascuñana, M, Fatas, M, Ribas, G, de Yébenes, J, López Moreno, J, Schwarz, C, Cubillo, P, Arques, P, Gorospe, A, Legarda, I, Torres Rodríguez, M, Gaston, I, Ramos Arroyo, Ma, Del Val, Jl, Martinez, L, Burgunder, Jm, Romero, I, Schüpbach, M, Zaugg, Sw, van Hout, M, van Vugt, Jp, de Weert, Am, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom, Jc, Bos, R, Dumas, E, Jurgens, Ck, Roos, Ra, Witjes Ané, Mn, Matheson, K, Rae, D, Simpson, S, Summers, F, Ure, A, Curtis, A, Keylock, J, Rickards, H, Wright, J, Barker, R, Fisher, K, Goodman, Ag, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Ellison Rose, L, Handley, O, Dunnett, S, Naji, J, Price, K, Rosser, A, Edwards, M, De Sousa, P, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Zema, A, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Thomas, G, Burrows, L, Fletcher, A, Laver, F, Silva, M, Thomson, A, Chu, C, Hobson, E, Jamieson, S, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Grant, J, Gross, D, Hallam, C, Middleton, J, Murch, A, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Bruno, S, Henley, S, Novak, M, O'Driscoll, C, Patel, A, Rosser, E, Tabrizi, S, Taylor, R, Warner, T, Arran, N, Fullam, R, Howard, L, Huson, S, Partington Jones, L, Ritchie, N, Snowden, J, Solom, A, Stopford, C, Thompson, J, Westmoreland, L, Nemeth, A, Siuda, G, Bandmann, O, Bradbury, A, Fillingham, K, Foustanos, I, Quarrell, O, Reynders, H, Robertson, L, and Tidswell, K.
Published: 2010

39. Transatlantic Relations and Flexibility within the AFSJ

Author: Fahey, E., Santos Vara, J., and Blockmans, S.
Subjects: JN, JZ
Abstract: Variable geometry may constitute an entity that appears to be constantly evolving through the Treaties, however, the UK and Ireland, together with Denmark, appear to be its principal beneficiaries thereof, obtaining positions that new accession States are unable to achieve and thus generating lopsided contours to the phenomenon. The opt-out/in provisions ostensibly indicate an outward constitutional stance of isolation towards further and deeper integration and seem to have generated much legal even political incoherence.The paper analyses in detail the impact of the Protocols upon the international relations agreements of the EU, particularly their operation in the specific case of EU-US relations, on the basis of the practice that has developed since the entry into force of the Treaty of Lisbon. Nevertheless, this variable geometry does not in recent years appear to have complicated the negotiation of international agreements dealing with criminal justice and policing measures. Even though it is perhaps too early to establish a definite picture on the UK implication in the external dimension of the AFSJ, it seems clear that the UK is committed to intensify international cooperation in matters dealing with criminal justice and policing measures.
Published: 2014

40. Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)

Author: Krafsur, G., Ehrhart, E. J., Ramos-Vara, J., Mason, G., Sarren, F., Adams, B., Hanns, C., Spraker, T., and Duncan, C.
Subjects: Article Subject
Abstract: The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion.
Published: 2014
Full Text: View/download PDF

41. Comunicación corta. La marchitez del pepino invernal causada por Pythium irregulare en el sureste de España

Author: Serrano-Alonso, Y. and Melero-Vara, J. M.
Subjects: fungi, Cucumis sativus, cultivo sin suelo, etiología, mermas de cosecha, oomycetos, patógenos zoospóricos, food and beverages, aetiology, fruit yield, oomycetes, soil-less crops, zoosporic pathogens
Abstract: Pythium irregulare was isolated from adult cucumber plants with stem base necrosis, wilt or, frequently, that were dead; symptoms were particularly observed in crops grown in winter in plastic-houses in south eastern Spain. Damage was often important because symptoms develop during the fruit harvesting period. Cucumber plants cv. Nevada sown in late September were inoculated at the 4-7 leaf stage (mid October) with a suspension of propagules of P. irregulare isolated from diseased cucumber or tomato plants. Non-inoculated plants served as controls. Symptoms were recorded weekly until the end of the experiment in mid January and cumulative marketable yields calculated. The experiment was repeated the following year. A high incidence (93.1 and 97.9%) of diseased or dead plants occurred in plots inoculated with isolates of P. irregulare from cucumber, which were significantly more aggressive than tomato isolates. Plants in non-inoculated plots remained symptom free. Yields were significantly lower in plots inoculated with cucumber isolates in both years, mainly due to reductions in the number of fruits rather than fruit weight. This is the first report of P. irregulare as the causal agent of root rot in plastic-houses of cucumber plants in Almería (Spain), one of the world’s largest concentrations of plastic-houses., Pythium irregulare se aisló de plantas adultas de pepino con necrosis en la base del tallo, marchitez y, a menudo, muertas; síntomas que fueron particularmente observados en los cultivos de invierno de los invernaderos del sudeste de España. Los daños fueron frecuentemente importantes porque los síntomas se manifestaron durante la recolección de los frutos. A mediados de octubre se inocularon plantas de pepino del cv. Nevada, en estado de 4-7 hojas verdaderas, que habían sido sembradas a finales de septiembre. La inoculación se realizó con suspensiones acuosas de estructuras de varios aislados de P. irregulare obtenidos de plantas enfermas de pepino o tomate. Plantas no inoculadas sirvieron como testigos. Los síntomas se anotaron semanalmente hasta que finalizó el experimento a mediados de enero, y se calculó la producción acumulada de frutos comercializables. El experimento se repitió el año siguiente. Se observó un alto porcentaje (entre el 93,1 y el 97,9%) de plantas marchitas o muertas, en las parcelas inoculadas con los aislados de P. irregulare obtenidos de pepino, que fueron más agresivos que los de tomate. Las plantas no inoculadas permanecieron sin síntomas. En ambos experimentos, la producción de frutos fue significativamente más baja en las parcelas inoculadas con los aislados obtenidos de pepino, debido principalmente a la reducción del número de frutos más que al peso de éstos. Se señala por vez primera a P. irregulare como agente causal de la podredumbre de raíces de pepino en invernaderos de Almería (España), con la mayor concentración de invernaderos de plástico del mundo.
Published: 2011

42. Comunicación corta. La marchitez del pepino invernal causada por Pythium irregulare en el sureste de España

Author: Serrano-Alonso, Y. and Melero-Vara, J. M.
Subjects: soil-less crops, zoosporic pathogens, cultivo sin suelo, etiología, patógenos zoospóricos, aetiology, oomycetos, mermas de cosecha, Cucumis sativus, fruit yield, oomycetes
Abstract: Pythium irregulare was isolated from adult cucumber plants with stem base necrosis, wilt or, frequently, that were dead; symptoms were particularly observed in crops grown in winter in plastic-houses in south eastern Spain. Damage was often important because symptoms develop during the fruit harvesting period. Cucumber plants cv. Nevada sown in late September were inoculated at the 4-7 leaf stage (mid October) with a suspension of propagules of P. irregulare isolated from diseased cucumber or tomato plants. Non-inoculated plants served as controls. Symptoms were recorded weekly until the end of the experiment in mid January and cumulative marketable yields calculated. The experiment was repeated the following year. A high incidence (93.1 and 97.9%) of diseased or dead plants occurred in plots inoculated with isolates of P. irregulare from cucumber, which were significantly more aggressive than tomato isolates. Plants in non-inoculated plots remained symptom free. Yields were significantly lower in plots inoculated with cucumber isolates in both years, mainly due to reductions in the number of fruits rather than fruit weight. This is the first report of P. irregulare as the causal agent of root rot in plastic-houses of cucumber plants in Almería (Spain), one of the world’s largest concentrations of plastic-houses. Pythium irregularese aisló de plantas adultas de pepino con necrosis en la base del tallo, marchitez y, a menudo, muertas; síntomas que fueron particularmente observados en los cultivos de invierno de los invernaderos del sudeste de España. Los daños fueron frecuentemente importantes porque los síntomas se manifestaron durante la recolección de los frutos. A mediados de octubre se inocularon plantas de pepino del cv. Nevada, en estado de 4-7 hojas verdaderas, que habían sido sembradas a finales de septiembre. La inoculación se realizó con suspensiones acuosas de estructuras de varios aislados de P. irregulare obtenidos de plantas enfermas de pepino o tomate. Plantas no inoculadas sirvieron como testigos. Los síntomas se anotaron semanalmente hasta que finalizó el experimento a mediados de enero, y se calculó la producción acumulada de frutos comercializables. El experimento se repitió el año siguiente. Se observó un alto porcentaje (entre el 93,1 y el 97,9%) de plantas marchitas o muertas, en las parcelas inoculadas con los aislados de P. irregulare obtenidos de pepino, que fueron más agresivos que los de tomate. Las plantas no inoculadas permanecieron sin síntomas. En ambos experimentos, la producción de frutos fue significativamente más baja en las parcelas inoculadas con los aislados obtenidos de pepino, debido principalmente a la reducción del número de frutos más que al peso de éstos. Se señala por vez primera a P. irregulare como agente causal de la podredumbre de raíces de pepino en invernaderos de Almería (España), con la mayor concentración de invernaderos de plástico del mundo.
Published: 2011

43. New mutations in the BCS1L gene in a patient with a lethal syndrome with cholestasis, liver failure, tubulopathy and microcephaly

Author: Garcia, M., Gil-Borlado, Mc., González-Hoyuela, M., Manzanares, J., Vara, J., Seneca, Sara, Medina, E., Urruzuno, P., López Alonso, G., Arenas, J., Ugalde, Christina, and Department of Embryology and Genetics
Subjects: GRACILE
Abstract: GRACILE syndrome, caused by mutations in the BCS1L gene, is a neonatal metabolic disorder characterized by: fetal growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death. The incidence in Finland is estimated to be 1 in 56,000 newborns, with a carrier frequency of 1 in 120, with autosomal recessive inheritance. Other patients reported with mutations in BCS1L have different clinical phenotypes with encephalopathic symptoms associated to hepatorenal disease. Patient: He presented with failure to thrive, cholestasis, liver failure, ascites, and a severe renal Toni-Fanconi-Debré Syndrome. Laboratory determinations showed high levels of transaminases, bilirubin, alkaline phosphatase, very high _-fetoprotein, metabolic acidosis with hyperlactacidemia and hyperaminoaciduria, hypocarnitinemia, fasting hypoglycemia with hyperglycemia after feeding or iv glucose, severe anaemia with normal transferrin and a bleeding disorder. Microcephaly was evident at the age of 6 months but brain MR spectroscopy was normal. At age 11 moths he died because of liver failure, increased ascites and a septicaemia. Liver biopsy showed cholestasis and fibrosis ducts proliferation without iron deposits, glycogen or lipids storage. Muscle biopsy showed increased glycogen and an isolated mitochondrial respiratory chain complex III deficiency. Methods: The BCS1L gene was investigated by direct sequencing and RFLP analysis. The patient is a heterozygous compound for the R56X mutation and for two new mutations that predict structural alterations in the 5'UTR region of the BCS1L mRNA. Conclusions: Mutations in the BCS1L gene could be underdiagnosed in non-Finnish patients with neonatal onset of hepatorenal diseases or variants of GRACILE syndrome.
Published: 2007

44. Characterization of natural occurring Pneumocystis carinii pneumonia in pigs by histopathology, electron microscopy, in situ hybridization and PCR amplification

Author: Ramos Vara, J. A., Lu, J. J., da Silva, A. J., Montone, K. T., Pieniazek, N. J., Lee, C. H., Pérez, L., Steficek, B. A., Dunstan, R. W., Craft, D., and Watson, G. L.
Subjects: PCR, 6 - Ciencias aplicadas::61 - Medicina [CDU], Electron mi croscope, Pneumonia, Pneumocistis carinii
Abstract: Macroscopic. histolog ic . ultrastruc tural. microbiologic. ill sirll hybridi za ti on (ISH ) and PCR detection results in three 8-week-old pi gs naturall y infected with Pllel.llllonsris c{lrinii (PC) are described . All an imals had a nonsu ppurati ve interstitial pneumoni a and intra-alveolar PlleulIlucysris organisms with foamy eos in ophili c and PAS positi ve appearance . Ultrastructurally. PC trophozoites and cysts we re observed in pigs No.2 and NO .3. with the fo rmer being much more numerous. PC organisms we re located on the alveolar surface or within the alveolar septa . Trophozoites had numerous filopodia and were thin-wall ed. Cysts had no o r few filopodia. we re thick- wa ll ed and co nt a ined intracysti c bodies. Using non-isotopic ISH on formalinfixed. paraffin-embedded lung tissue sections. PC DNA from pigs No.2 and No . 3 hyb ridi zed with a probe specific for PC ribosomal RNA (rRNA). Using primers spec ific for mit oc ho ndrial rRNA ge ne (pA Z I0 2- E/pAZ I 02-H). and for the interna l transcriber space rs of ribosomal gene of PC. PCR methods amplified a product in the lung of pigs No.2 and No.3 using either frozen or formalin -fi xed and paraffin -embedded lung tissue. DNA from Pig No. I samples did not amplify with any primer. This is the first time that molecular biology techniques (ill siru hybridi zation and PCR) have been applied to the study of porc ine pneumocystosis.
Published: 1998

45. A comparative study of electrodeposited and vapour deposited gold films : Fractal surface characterization through scanning tunnelling microscopy

Author: Herrasti, P., Ocón, P., Salvarezza, Roberto Carlos, Vara, J. M., Vásquez, L., and Arvia, Alejandro Jorge
Subjects: Electrocrystallization, Metal vapour deposition, Gold electrodes, Fractal surfaces, Química, Scanning tunneling microscopy, Ciencias Exactas
Abstract: The surfaces of Au deposits grown under non-equilibrium conditions from either the electroreduction of Au oxide or from the vapour have been analysed as fractals by measuring the perimeter (P) and the area (A) of intergranular voids. The values of P and A were determined from scanning tunnelling microscopy (STM) topographic imaging of the deposit surfaces. A frsctal behaviour P ∝ 4 D/2 was found with D = 1.5 ± 0.1 and D = 1.7 ± 0.1 for the electrodeposited and vapour deposited Au iilms, respectively. These figures remain constant for film thicknesses between 100 and 1000 mn. The value of D, the fractal dimension of the surfaces, is 2.5 ± 0.1 for the Au electrodeposits, and 2.7 + 0.1 for the Au vapour deposited films. The former value is consistent with either a diffusion or an electric field controlled growth model, whereas the latter is in agreement with a ballistic growth model., Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Published: 1992

46. Caída de s en griego antiguo y fenómenos concomitantes

Author: Vara, J.
Subjects: lcsh:Philology. Linguistics, lcsh:P1-1091, P1-1091, Philology. Linguistics
Abstract: In old Greek the sound s is lost as a consequence of the pressure of the system on the sequence of the apicals. It follows a chain of phenomena, analysed in this paper, which could be summarized like this: 1. A general assibilation occurs in some dialects; as a result of it ti becomes si, the place of the sound s in the system being empty on account of its former disappearance. In other dialects the assibilation does not occur. 2. In the dialects which have undergone the general assibilation, ts becomes ss, on the analogy of the assibilation of ti into si; while in those dialects in which the assibilation has not occurred, ts changes into ti. 3. Further changes occur due to the extensive working of analogy: in the dialects in which ts has become ss, zd changes into zz, by analogy to ss. On the other hand, in those dialects which have undergone the change of ts into tt, zd becomes dd, on the analogy of tt. 4. Later on, the place of ti in the paradigm being empty in the former dialects because of its having become si, it is replaced by the labial velar ku̯i, which finally becomes ti, however anomalous this change may seem. While in the dialects in which te is preserved, not having become se, the labial-velar ku̯i usually results in pe, not te. The logic underlying this theory and its formulation will be found in the whole paper., No disponible.
Published: 1984
Full Text: View/download PDF

47. Aportación al conocimiento del texto de la Historia de los animales de Eliano y asuntos conexos

Author: Vara, J.
Subjects: lcsh:Philology. Linguistics, lcsh:P1-1091, P1-1091, Philology. Linguistics
Abstract: The author gives some examples in order to demonstrate that Aelian took most of his stories in Historia Animalium from previous works, especially from the Historia Animalium by Aristotle, the De sollertia animalium by Plutarch, the Naturalis Historia by Pliny and also from works by Oppian and Athenaeus., No disponible.
Published: 1987
Full Text: View/download PDF

48. Motor Fluctuations development is associated with non-motor symptoms burden progression in Parkinson's disease patients: A 2-year follow-up study

Author: Santos, D., Deus, T., Cores, C., Feal Painceiras, M., Suarez Castro, E., Martinez, C., Jesus, S., Aguilar, M., Pastor, P., Planellas, L., Cosgaya, M., Garcia Caldentey, J., Caballol, N., Legarda, I., Hernandez Vara, J., Cabo, I., Lopez Manzanares, L., Gonzalez Aramburu, I., Avila, M., Gomez Mayordomo, V., Nogueira, V., Puente, V., Dotor, J., Borrue, C., Solano, B., Alvarez Sauco, M., Vela, L., Escalante, S., Cubo, E., Carrillo, F., Martinez Castrillo, J., Sanchez Alonso, P., Alonso Losada, M., Lopez Ariztegui, N., Gaston, I., Jaime Kulisevsky, Blazquez, M., Seijo, M., Ruiz Martinez, J., Valero, C., Kurtis, M., Fabregues, O., Gonzalez, J., Alonso Redondo, R., Ordas, C., Lopez Diaz, L., Mcafee, D., Martinez Martin, P., Mir, P., and Coppadis, C.
Subjects: motor fluctuations, Parkinson's disease, follow-up, non-motor symptoms, burden
Abstract: Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score >= 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 +/- 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 +/- 36.48 vs. 34.3 +/- 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 +/- 37.37) compared to those who did not develop MF (+6.2 +/- 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (beta = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.

49. Visualizing traceability information with iTrace

Author: Santiago, I., Vara, J. M., Maria Valeria de Castro, and Marcos, E.

50. Pathological findings in a cat with cryptococcosis and feline immunodeficiency virus infection

Author: Ramos-Vara, J. A., Lluís Ferrer, and Visa, J.

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

87 results on '"Vara, J."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources