1. Superfast Synthesis of Stabilized Silver Nanoparticles Using Aqueous
- Author
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Jamal Moideen Muthu, Mohamed, Ali, Alqahtani, Thankakan Vimala Ajay, Kumar, Adel Al, Fatease, Taha, Alqahtani, Venkatesan, Krishnaraju, Fazil, Ahmad, Farid, Menaa, Ali, Alamri, Ranjini, Muthumani, and Rajendran, Vijaya
- Subjects
silver nanoparticles ,garlic extract ,Binding Sites ,Silver ,Plant Extracts ,Spectrum Analysis ,green synthesis ,Phytochemicals ,isoniazid hydrazide ,Antitubercular Agents ,Metal Nanoparticles ,Green Chemistry Technology ,Chemistry Techniques, Synthetic ,molecular docking ,Molecular Dynamics Simulation ,Ligands ,Article ,Molecular Docking Simulation ,Structure-Activity Relationship ,Hydrazines ,Drug Stability ,nanoconjugates ,Isoniazid ,Garlic ,Protein Binding - Abstract
Green synthesis of silver nanoparticles (AgNPs) was synthesized from fresh garlic extract coupled with isoniazid hydrazide (INH), a commonly used antibiotic to treat tuberculosis. A molecular docking study conducted with the selected compounds compared with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis. The aqueous extract of garlic was prepared and mixed with silver nitrate (AgNO3) solution for the superfast synthesis of stable AgNPs. INH was then conjugated with AgNPs at different ratios (v/v) to obtain stable INH-AgNPs conjugates (AgNCs). The resulting AgNCs characterized by FTIR spectra revealed the ultrafast formation of AgNPs (
- Published
- 2021