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STEM (science, technology, engineering, mathematics) education has become a global agenda, with schooling systems around the world in developed and developing countries seeking to incorporate STEM programs into their in-school and out-of-school curricula. While disciplinary integration has been common practice in primary (elementary) schooling for many decades, in the early 21st century the STEM education movement has promoted an increased focus on project- and problem-based learning across disciplines in secondary schools as well. Research suggests, however, that STEM education programs can face barriers in their implementation, often depending on whether they are designed to align with existing curriculum outcomes or whether they are developed as cocurricular programs. Challenges are also presented by the need for professional learning to equip teachers with new skills and knowledge in designing and delivering STEM education. In addition, some researchers and educators have argued for STEAM—integration of the arts in STEM education. For those concerned with school reform, a great strength of STEM and STEAM education approaches lies in the potential for transdisciplinarity. As such, new opportunities and possibilities for framing driving questions and addressing contemporary societal challenges are created. Two particular issues identified as critical are (a) the potential contribution of STEM education to creating a sustainable future, and (b) the importance of STEM education for social justice, in ensuring all children and young people have equitable access to learning opportunities.

This paper provides a perspective on how art and cross-cultural conversations can facilitate understanding of important scientific processes, outcomes and conclusions, using the Marine Ecosystem Assessment for the Southern Ocean (MEASO) as a case study. First, we reflect on our rationale and approach, describing the importance of deeper communication, such as through the arts, to the policy process; more enduring decisions are possible by engaging and obtaining perspectives through more than just a utilitarian lens. Second, we draw on the LivingData Website [http://www.livingdata.net.au] where art in all its forms is made to bridge differences in knowledge systems and their values, provide examples of how Indigenous knowledge and Western science can be complementary, and how Indigenous knowledge can show the difference between historical natural environmental phenomena and current unnatural phenomena, including how the Anthropocene is disrupting cultural connections with the environment that ultimately impact everyone. Lastly, we document the non-linear process of our experience and draw lessons from it that can guide deeper communication between disciples and cultures, to potentially benefit decision-making. Our perspective is derived as a collective from diverse backgrounds, histories, knowledge systems and values.

Full details of the Model implementation and input/parameters used from publisehd data sources

Indonesia merupakan negara kepulauan terbesar didunia dengan lebih dari 17 ribu pulau. Untuk Negara yang terdiri dari kepulauan dan lautan ini dibutuhkan sistem angkutan antar moda, yang menghubungkan antar pulau yang tersebar, demi menciptakan sistem transportasi yang aman, efektif dan efisien. Pengiriman barang merupakan salah satu proses logistik yang utama, sehingga penting untuk dikaji lebih dalam. Dalam proses pengiriman barang, dibutuhkan suatu sistem yang dapat memberi gambaran tentang waktu dan biaya angkutan multimoda yang paling efektif dan efisien. Pada penelitian ini, dibangun Sistem Informasi yang dapat membantu user dalam mengambil keputusan untuk mengoptimalkan waktu dan biaya pengiriman barang, sehingga dapat menunjukan segala kemungkinan multimoda yang dapat digunakan dalam proses pengiriman barang. Sistem Multimoda yang diterapkan yaitu angkutan dari pabrik menuju ke pangkal jalur utama pertama pada suatu kota asal (stasiun kereta api, kargo pesawat udara, kargo pelabuhan kapal laut) menuju lokasi tujuan/transit. Dan angkutan dari jalur utama pada kota tujuan/transit menuju gudang, atau menuju jalur utama selanjutnya. Pada sistem informasi ini, hal yang dipertimbangkan adalah biaya dan waktu perjalanannya dari 4 moda, yaitu Darat, Laut, Udara dan Kereta Api, dengan mempertimbangkan segala kemungkinan multimoda yang dapat digunakan. Sistem ini juga dapat menghitung untuk lokasi tujuan yang hanya dapat dilalui moda tertentu saja. Pada perhitungan single moda, digunakan Algoritma Kruskal dalam perhitungan rute terpendek.

Solid tumor needle biopsies are essential to confirm malignancy and assess for actionable characteristics or genetic alterations to guide treatment selection. Ensuring that sufficient and suitable material is acquired for tumor profiling, while minimizing patient risk, remains a critical unmet need. Here, we evaluated the performance characteristics of transmission optical spectroscopy for rapid identification of malignant tissue in core needle biopsies (CNB). Human kidney biopsy specimens (545 CNB from 102 patients, 5583 spectra for analysis) were analyzed directly on core biopsy needles with a custom-built optical spectroscopy instrument. Machine learning classifiers were trained to differentiate malignant from normal tissue spectra. Classifiers were compared using receiver operating characteristics analysis and sensitivity and specificity were calculated relative to a histopathologic gold standard. The best performing algorithm was the random forest (sensitivity 96% and 93%, specificity 90% and 93% at the level of individual spectra and full CNB, respectively).Ex-vivospectroscopy paired with machine learning paves the way towards rapid and accurate characterization of CNB at the time of tissue acquisition and improving tumor biopsy quality.

Detecting opportunities for between-species transmission of pathogens can be challenging, particularly if rare behaviours or environmental transmission are involved. We present a multilayer network framework to quantify transmission potential in multi-host systems, incorporating environmental transmission, by using empirical data on direct and indirect contacts between European badgers Meles meles and domestic cattle. We identify that indirect contacts via the environment at badger latrines on pasture are likely to be important for transmission within badger populations and between badgers and cattle. We also find a positive correlation between the role of individual badgers within the badger social network, and their role in the overall badger-cattle-environment network, suggesting that the same behavioural traits contribute to the role of individual badgers in within- and between-species transmission. These findings have implications for disease management interventions in this system, and our novel network approach can provide general insights into transmission in other multi-host disease systems.

In this paper, we propose an analysis and evaluation of the four most recent and authoritative general monolingual dictionaries of Greek as texts produced by an identifiable agent and addressed to an identifiable public, that contribute to the ideology of standardization. Our claim is that we can demonstrate the profile of each dictionary and uncover the lexicographer’s aspiration to set a pace to the standardization of Greek by looking at and comparing the choices that each of the lexicographers made with regard to aspects involved in the compilation and circulation of their dictionary. The discrepancies observed in the treatment of issues regarding the inclusion/exclusion of words and variants from their list of entries, the labelling of the words, the etymological information provided and the spelling used are explained by the different perspective that each lexicographer assumed in their quest to define the standard language for the Greek linguistic community

Advances in genomic sequencing have enormous potential to revolutionise personalised medicine, however distinguishing disease-causing from benign variants remains a challenge. The increasing number of human genome and exome sequences available has revealed areas where unfavourable variation is removed through purifying selection. Here we present the MTR-Viewer, a web-server enabling easy visualisation at the gene or variant level of the Missense Tolerance Ratio (MTR), a measure of regional intolerance to missense variation calculated using variation from 220,000 exome and genome sequences. The MTR-Viewer enables exploration of MTR calculations, using different sliding windows, for over 18,000 human protein-coding genes and 85,000 alternative transcripts. Users can also view MTR scores calculated for specific ethnicities, to enable easy exploration of regions that may be under different selective pressure. The spatial distribution of population and known disease variants is also displayed on the protein’s domain structure. Intolerant regions were found to be highly enriched for ClinVar pathogenic and COSMIC somatic missense variants (Mann-Whitney U test p < 2.2x10-16). As the MTR is not biased by known domains and protein features, it can highlight functionally important regions within genes overlooked or inaccessible by traditional methods. MTR-Viewer is freely available via a user friendly web-server at http://biosig.unimelb.edu.au/mtr-viewer/.

Neurodevelopmental disorders are highly heterogenous conditions resulting from abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain-containing 7), a recognized developmental regulator and tumor suppressor, has been shown to regulate cell-cycle progression and cell growth and survival by targeting substrates including CYCLIN E1/2 and NOTCH for degradation via the ubiquitin proteasome system. We used a genotype-first approach and global data-sharing platforms to identify 35 individuals harboring de novo and inherited FBXW7 germline monoallelic chromosomal deletions and nonsense, frameshift, splice-site, and missense variants associated with a neurodevelopmental syndrome. The FBXW7 neurodevelopmental syndrome is distinguished by global developmental delay, borderline to severe intellectual disability, hypotonia, and gastrointestinal issues. Brain imaging detailed variable underlying structural abnormalities affecting the cerebellum, corpus collosum, and white matter. A crystal-structure model of FBXW7 predicted that missense variants were clustered at the substrate-binding surface of the WD40 domain and that these might reduce FBXW7 substrate binding affinity. Expression of recombinant FBXW7 missense variants in cultured cells demonstrated impaired CYCLIN E1 and CYCLIN E2 turnover. Pan-neuronal knockdown of the Drosophila ortholog, archipelago, impaired learning and neuronal function. Collectively, the data presented herein provide compelling evidence of an F-Box protein-related, phenotypically variable neurodevelopmental disorder associated with monoallelic variants in FBXW7.