Search

The burden of allergic illnesses is continuously rising, and patient diagnosis is a significant problem because of how intricately hereditary and environmental variables interact. The past three to four decades have seen an outbreak of allergies in high-income countries. According to reports on the illness, asthma affects around 300 million individuals worldwide. Identifying clinically important allergens for the accurate classification of IgE-mediated allergy respiratory disease diagnosis would be beneficial for implementing standardized allergen-associated therapy. Therefore, the current study includes an in silico analysis to identify potential IgE-mediated allergens in date palms and cockroaches. Such an immunoinformatic approach aids the prioritization of allergens with probable involvement in IgE-mediated allergic respiratory diseases. Immunoglobulin E (IgE) was used for molecular dynamic simulations, antigen-antibody docking analyses, epitope identifications, and characterizations. The potential of these allergens (Per a7, Per a 1.0102, and Bla g 1.0101) in IgE-mediated allergic respiratory diseases was explored through the evaluation of physicochemical characteristics, interaction observations, docking, and molecular dynamics simulations for drug and vaccine development. more...

Ginger (Zingiber officinale) is a common kitchen spice that belongs to the family Zingiberaceae. It is rich in phytochemistry that is promoting health benefits. It is used as a home remedy to support the common cold, headaches, and pharmacological properties such as anti-inflammatory, antioxidant, antiemetic, antiulcer, and anti-cancer, antiplatelet, anti-diabetic and lipid-lowering activities. Gingerols are key ingredients found in ginger that convert into zingerone, shogaol, and parasols, giving flavor and odor. Zingerone and shogaol are present in limited quantities in fresh ginger and more in dried or extracted goods. Especially 6-gingerol and 6-shogaol are pharmacological properties that are effective in antipyretic, analgesic, and hypotensive. The present review is about different therapeutic properties of ginger, including antioxidant properties, anti-diabetic properties, anti-cancer properties etc. more...

Background: The diseases due to nutritional deficiencies or imbalanced diet can be due to different factors. These factors can be biological or environmental. The study indicated that there will be increase risks of acquiring diseases as a result of irregular intake of diet. These risks include the increased risk of diseases such as liver abnormality, hypertension, lipids deposition, and other diseases. Methodology: The databases used for the collection of secondary information include Science Direct, PubMed, and Google Scholar. Besides, the keywords used for the searching of relevant research articles include “experimental rats, nutritional deficiencies. Hypothalamus, mechanisms studies, gene ontology, metabolic syndromes”. There were the use of female rats (n=8) and the weight was ranged between 200 to 250 grams. The experimental rats were placed in a cycle of 12 h light/dark. An adequate amount of water and food was provided for about one week to the rats before starting the experiment. Enzymatic procedures were used for the analysis of cholesterol, fatty acids, and triglycerides. Glucose concentrations in the blood samples were also assessed using the glucose meter. The insulin levels were also measured by using the assay kits. The hybridisation, scanning, and normalization of the data were also done. The extracted RNA from the hypothalamus was transcribed by using the “Superscript II RNAseH- Reverse-Transcriptase”. The t-test was also performed using statistical software. The groups of genes and their altered expressions were studied after the malnutrition conditions. The results obtained through PCR were expressed in the form of average and standard deviation values [1]. The mRNA expression levels in the samples of the hypothalamus were also assessed. The data were compared using the student test. The significance levels were measured at p < 0.05. Findings: The findings of the study also indicated that the transcription of co-regulators is also link with the nutritional and temporal cues to the metabolism process by means of their association with circadian clock. The findings revealed that the hypothalamic circuits and its nutritional programming plays significant role in the regulation of energy homeostasis which is a major factor of obesity development in association with malnutrition in early life development. Conclusion: Conclusively, it has been identified that the deficiency of nutrients during developmental period such as prenatal and postnatal is linked with the enhanced risk of different types of diseases in childhood as well as in adulthood. more...

This research study aims to analyze the impact of caffeine on the physical and mental health of university students within the United Kingdom. The research has made use of a mixed-methods methodology, involving both the qualitative and quantitative analysis methods, to collect and analyze secondary data to meet the objectives. The data for this study has been collected from case studies enunciated and highlighted in the previous research studies in this subject area and using that data, the analysis was conducted to analyze the impact of caffeine in the context of the target population. The results of the study suggest that impact is a function of the quantity of caffeine consumed by university students. This is to say that if the quantity suggested by the health experts has been consumed by students, then there is no potential negative health outcome. But if an increased quantity has been consumed, then, as per the findings of this study, several negative mental health statuses of students in the UK may be observed. more...

The present work was conducted to study the effect of low fat diet (LFD), almonds, green coffee, mackerel fish and the combination of all of them on loss of weight, lipid profile, serum glucose, leptin hormone, liver enzymes and kidney functions of obese rats. Methods: In this research, researcher used normal male albino rats (n=42). This group of rats was divided into two major groups. The first group (n=6 rats) fed on standard diet and was considered as a group of negative control. The second group (n= 36 rat) fed high fat diet for six weeks on to induce of obesity. Rats in the second group were randomly assigned to six equal subgroups: Subgroup (1) fed on HFD (consist of 20% fat) and used as (control positive) 1; Subgroups (2) fed on LFD containing only (10% fat) and used as (control positive) 2. Subgroup The third sub-group feeds on low fat diet LFD containing (almonds, which provided the diet with 5% oil hydrogenated oils 4% and soy oil 1%). Subgroup (4) fed on LFD and treated each rat daily in this group with 3 ml green coffee. Subgroup (5) fed on LFD containing (mackerel fish, which provided the diet with 5% fat, hydrogenated oils 4% and soy oil 1%). Subgroup (6) fed on LFD containing (almonds which provided the diet with 5% oil and mackerel fish which provided the diet with 5% oil) and treated each rat daily in this group with 3 ml green coffee The obtained data were tested with one-way ANOVA (mean ± standard deviation and one-way ANOVA test) using SAS package and compared with each other using the LSD (least significant differences at P< 0.05. Results: Body weight gain % of rats increased significantly by feeding on a high-fat diet, also, serum "glucose, leptin hormone, cholesterol, triglyceride, lipoprotein cholesterol except HDL-c, kidney functions, liver increased in rats fed on HFD, while high-density lipoprotein cholesterol decreased, in comparison with the group of negative control group fed on basal diet. Conclusion: Treatment of obese rats with LFDs, LFDs containing almond, LFDs containing green coffee, LFDs containing mackerel fish, and obese rats treated with all these improved all parameters. more...

The burden of allergic illnesses is continuously rising, and patient diagnosis is a significant problem because of how intricately hereditary and environmental variables interact. The past three to four decades have seen an outbreak of allergies in high-income countries. According to reports on the illness, asthma affects around 300 million individuals worldwide. Identifying clinically important allergens for the accurate classification of IgE-mediated allergy respiratory disease diagnosis would be beneficial for implementing standardized allergen-associated therapy. Therefore, the current study includes an in silico analysis to identify potential IgE-mediated allergens in date palms and cockroaches. Such an immunoinformatic approach aids the prioritization of allergens with probable involvement in IgE-mediated allergic respiratory diseases. Immunoglobulin E (IgE) was used for molecular dynamic simulations, antigen–antibody docking analyses, epitope identifications, and characterizations. The potential of these allergens (Per a7, Per a 1.0102, and Bla g 1.0101) in IgE-mediated allergic respiratory diseases was explored through the evaluation of physicochemical characteristics, interaction observations, docking, and molecular dynamics simulations for drug and vaccine development. more...