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Objective To investigate the clinicopathological features of pulmonary adenocarcinoma ⁃ to ⁃ meningioma metastasis with meningeal carcinomatosis, and to reduce the rate of missed diagnosis of this disease. Methods and Results A 58⁃year⁃old female was admitted to hospital due to repeated headaches for 4 years and increased dizziness and vomiting for 2 months. Head MRI showed a space ⁃ occupying lesion in left apical petrous cross middle posterior fossa (mainly in the posterior fossa). Microscopy showed the tumor was mainly composed of meningothelial meningioma. In addition, the implantation of adenocarcinoma cells on the surface of arachnoid, and the small tumor adenocarcinoma nests in the meningioma were found. The cerebrospinal fluid cytology found heterotypic tumor cells. Immunohistochemical staining showed meningioma components expressed progesterone receptor (PR), somatostatin receptor 2 (SSTR2), Ki ⁃ 67 proliferation index was 3% ; adenocarcinoma components express cytokeratin (CK), cytokeratin 7 (CK7), thyroid transcription factor ⁃ 1 (TTF ⁃ 1), aspartic protease A (Napsin A), Ki⁃67 proliferation index was 30% . Epithelial membrane antigen (EMA) was stained of two components. Final pathological diagnosis was pulmonary adenocarcinoma ⁃ to ⁃ meningioma metastasis with meningeal carcinomatosis. Conclusions Pulmonary adenocarcinoma⁃to⁃meningoma metastasis is uncommon, So far, there are 20 cases reported. It is common in the elderly, mostly in women, with poor prognosis. Accurate diagnosis depends on histopathological, and should be combined with clinical, imaging, cerebrospinal fluid cytology, multidisciplinary diagnosis can avoid missed diagnosis. DOI：10.3969/j.issn.1672⁃6731.2020.04.013

Objective To investigate the clinical characteristics of meningeal carcinomatosis with nervous system syndrome as initial symptom. Methods Clinical data, laboratory and imageing examinations were retrospectively analyzed in 23 patients of meningeal carcinomatosis from June 2009 to December 2017. Results Twenty patients (86.96%) had headache as initial symptom and 12 (52.17%) had headache with vomiting. Head enhanced MRI showed obvious enhancement in meningeal lesions,and 13 cases (59.09%) had meningeal enhancement with enlargement of ventricular system; CT showed enlargement of supratentorial ventricular system (1 case). About 65.22% (15/23) primary lesions were originated from lungcancer,and others were or iginated from colon cancer,hematological lymphoma,gastric cancer, spinal astrocytoma (4.35%, 1/23 respectively), and some unknown origin (17.39%, 4/23). About 82.61% (19/23) patients cerebrospinal fluid pressure increased obviously, Tumor markers especially carcinoembryonic antigen (CEA) were mostly increased in serum (11/17) and cerebrospinal fluid (7/10). Conclusions Headache and vomiting are the most common clinical symptoms of meningeal carcinomatosis. Enhanced MRI shows meningeal enhancement or communicating hydrocephalus. Cerebrospinal fluid pressure tends to increase significantly. Carcinoembryonic antigen is significantly increased in serum and cerebrospinal fluid. Primary lesions of meningeal carcinomatosis mostly originate fromlungcancer. Finding tumor cells in cerebrospinal fluid is the" golden standard" of diagnosis.

To investigate the effect of a modified Wuzi Yanzong Pill (五子衍宗丸, WZYZP) on the male rats’ testis after microwave radiation, as well as its potential mechanism. Forty-five male rats were randomly assigned to three groups: the control group, the radiation group, and the WZYZP group. The rats in the radiation group and WZYZP group were exposed to microwave radiation for 15 min once, while the rats in the control group were not exposed to any radiation. The rats in the WZYZP group were given a modified of WZYZP by gavage daily for 7 days. Apoptosis in the testis was evaluated using terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) assay. Histopathological alterations of the testis were observed by haematoxylin-eosin (HE) staining. Tat-interactive protein, 60kD (Tip60) and p53 expressions were determined by Western blotting. The apoptosis index (AI) in the radiation group was higher than that of the WZYZP group and control group on day 1 (D1), day 7 (D7) day 14 (D14) after radiation (P

Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of HI9 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene-environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H/9-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51 % ± 10.54%, P

To investigate the effect of a modified Wuzi Yanzong Pill (, WZYZP) on the male rats' testis after microwave radiation, as well as its potential mechanism.Forty-five male rats were randomly assigned to three groups: the control group, the radiation group, and the WZYZP group. The rats in the radiation group and WZYZP group were exposed to microwave radiation for 15 min once, while the rats in the control group were not exposed to any radiation. The rats in the WZYZP group were given a modified of WZYZP by gavage daily for 7 days. Apoptosis in the testis was evaluated using terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) assay. Histopathological alterations of the testis were observed by haematoxylin-eosin (HE) staining. Tat-interactive protein, 60kD (Tip60) and p53 expressions were determined by Western blotting.The apoptosis index (AI) in the radiation group was higher than that of the WZYZP group and control group on day 1 (D1), day 7 (D7) day 14 (D14) after radiation (P0.05). The seminiferous tubules were of normal morphology in the control group. In the radiation group, the partial seminiferous tubules were collapsed, basement membranes of the seminiferous epithelia became detached. WZYZP could restore the morphological changes. There was no expression of Tip60 among the three groups on D7 and D14. The expression of p53 was higher in the radiation group than in the control group (P0.05). WZYZP could down-regulate the rising p53 induced by radiation on D7 and D14 (P0.05).A modified WZYZP may affect germ cells, and its protective effects may partly result from its ability to intervene in Tip60 mediated apoptosis.