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Abnormal Methylation of Imprinted Genes and Cigarette Smoking: Assessment of Their Association With the Risk of Male Infertility
- Source :
- Reproductive Sciences. 24:114-123
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Male infertility is a complicated disease with causes generally split into 2 broad categories: genetic factors and environmental factors. The present study was designed to investigate the association between the methylation patterns of HI9 and SNRPN imprinting control region (ICR) and male infertility and to assess the gene-environment interactions between environmental factors and methylation patterns. A total of 205 DNA samples from 48 oligozoospermia (OZ), 52 asthenozoospermia (AZ), 55 teratozoospermia (TZ) patients, and 50 normozoospermia (NZ) men were analyzed. The mean methylation level of H/9-ICR in OZ (80.40% ± 12.74%) and AZ patients (81.17% ± 13.18%) was significantly lower than methylation in men with NZ (88.51 % ± 10.54%, P
- Subjects :
- 0301 basic medicine
Gynecology
Infertility
medicine.medical_specialty
Obstetrics and Gynecology
Odds ratio
Methylation
Biology
medicine.disease
Asthenozoospermia
Male infertility
03 medical and health sciences
030104 developmental biology
Cigarette smoking
DNA methylation
medicine
Genomic imprinting
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....e96cf03b2f52986cc2a03642da16b3fa