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40 results on '"Shangina, O."'

1. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author: Goyal, N. Hennessy, M. Lehman, E. Lin, W. Agudo, A. Ahrens, W. Boccia, S. Brennan, P. Brenner, H. Cadoni, G. Canova, C. Chen, C. Conway, D. Curado, M. Dal Maso, L. Daudt, A.W. Edefonti, V. Fabianova, E. Fernandez, L. Franceschi, S. Garavello, W. Gillison, M. Hayes, R.B. Healy, C. Herrero, R. Holcatova, I. Kanda, J.L. Kelsey, K. Hansen, B. Koifman, R. Lagiou, P. La Vecchia, C. Levi, F. Li, G. Lissowska, J. Mendoza López, R. Luce, D. Macfarlane, G. Mates, D. Matsuo, K. McClean, M. Menezes, A. Menvielle, G. Morgenstern, H. Moysich, K. Negri, E. Olshan, A.F. Pandics, T. Polesel, J. Purdue, M. Radoi, L. Ramroth, H. Richiardi, L. Schantz, S. Schwartz, S.M. Serraino, D. Shangina, O. Smith, E. Sturgis, E.M. Świątkowska, B. Thomson, P. Vaughan, T.L. Vilensky, M. Winn, D.M. Wunsch-Filho, V. Yu, G.-P. Zevallos, J.P. Zhang, Z.-F. Zheng, T. Znaor, A. Boffetta, P. Hashibe, M. Lee, Y.-C.A. Muscat, J.E.
Abstract: Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (
Published: 2022

2. Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP

Author: Cheng, T. H. T., Gorman, M., Martin, L., Barclay, E., Casey, G., Newcomb, P. A., Conti, D. V., Schumacher, F. R., Gallinger, S., Lindor, N. M., Hopper, J., Jenkins, M., Hunter, D. J., Kraft, P., Jacobs, K. B., Cox, D. G., Yeager, M., Hankinson, S. E., Wacholder, S., Wang, Z., Welch, R., Hutchinson, A., Wang, J., Yu, K., Chatterjee, N., Orr, N., Willett, W. C., Colditz, G. A., Ziegler, R. G., Berg, C. D., Buys, S. S., McCarty, C. A., Feigelson, H. S., Calle, E. E., Thun, M. J., Hayes, R. B., Tucker, M., Gerhard, D. S., Fraumeni, J. F., Jr., Hoover, R. N., Thomas, G., Chanock, S. J., Ciampa, J., Gonzalez-Bosquet, J., Berndt, S., Amundadottir, L., Diver, W. R., Albanes, D., Virtamo, J., Weinstein, S. J., Cancel-Tassin, G., Cussenot, O., Valeri, A., Andriole, G. L., Crawford, E. D., Haiman, C. A., Henderson, B., Kolonel, L., March, L. L., Siddiq, A., Riboli, E., Key, T. J., Kaaks, R., Isaacs, W., Isaacs, S., Wiley, K. E., Gronberg, H., Wiklund, F., Stattin, P., Xu, J., Zheng, S. L., Sun, J., Vatten, L. J., Hveem, K., Kumle, M., Purdue, M. P., Johansson, M., Zelenika, D., Toro, J. R., Scelo, G., Moore, L. E., Prokhortchouk, E., Wu, X., Kiemeney, L. A., Gaborieau, V., Chow, W. -H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J. S., Davis, F. G., Schwartz, K. L., Banks, R. E., Selby, P. J., Harnden, P., Hsing, A. W., Grubb, R. L., III, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E. J., Quirós, J. R., Sanchez, M. -J., Navarro, C., Ardanaz, E., Dorronsoro, M., Khaw, K. -T., Allen, N. E., Bueno-de-Mesquita, H. B., Peeters, P. H. M., Trichopoulos, D., Linseisen, J., Ljungberg, B., Overvad, K., Tjønnel, Romieu, I., Mukeria, A., Shangina, O., Stevens, V. L., Gapstur, S. M., Pharoah, P. D., Easton, D. F., Njølstad, I., Tell, G. S., Stoltenberg, C., Kumar, R., Koppova, K., Benhamou, S., Oosterwijk, E., Vermeulen, S. H., Aben, K. K. H., Van Der Marel, S. L., Ye, Y., Wood, C. G., Pu, X., Mazur, A. M., Boulygina, E. S., Chekanov, N. N., Foglio, M., Lechner, D., Gut, I., Heath, S., Blanche, H., Skryabin, K. G., McKay, J. D., Rothman, N., Lathrop, M., Brennan, P., Saunders, B., Thomas, H., Clark, S., Tomlinson, I., and Cheng, T.H.T. and Gorman, M. and Martin, L. and Barclay, E. and Casey, G. and Newcomb, P.A. and Conti, D.V. and Schumacher, F.R. and Gallinger, S. and Lindor, N.M. and Hopper, J. and Jenkins, M. and Hunter, D.J. and Kraft, P. and Jacobs, K.B. and Cox, D.G. and Yeager, M. and Hankinson, S.E. and Wacholder, S. and Wang, Z. and Welch, R. and Hutchinson, A. and Wang, J. and Yu, K. and Chatterjee, N. and Orr, N. and Willett, W.C. and Colditz, G.A. and Ziegler, R.G. and Berg, C.D. and Buys, S.S. and McCarty, C.A. and Feigelson, H.S. and Calle, E.E. and Thun, M.J. and Hayes, R.B. and Tucker, M. and Gerhard, D.S. and Fraumeni, J.F., Jr. and Hoover, R.N. and Thomas, G. and Chanock, S.J. and Ciampa, J. and Gonzalez-Bosquet, J. and Berndt, S. and Amundadottir, L. and Diver, W.R. and Albanes, D. and Virtamo, J. and Weinstein, S.J. and Cancel-Tassin, G. and Cussenot, O. and Valeri, A. and Andriole, G.L. and Crawford, E.D. and Haiman, C.A. and Henderson, B. and Kolonel, L. and Marchand, L.L. and Siddiq, A. and Riboli, E. and Key, T.J. and Kaaks, R. and Isaacs, W. and Isaacs, S. and Wiley, K.E. and Gronberg, H. and Wiklund, F. and Stattin, P. and Xu, J. and Zheng, S.L. and Sun, J. and Vatten, L.J. and Hveem, K. and Kumle, M. and Purdue, M.P. and Johansson, M. and Zelenika, D. and Toro, J.R. and Scelo, G. and Moore, L.E. and Prokhortchouk, E. and Wu, X. and Kiemeney, L.A. and Gaborieau, V. and Chow, W.-H. and Zaridze, D. and Matveev, V. and Lubinski, J. and Trubicka, J. and Szeszenia-Dabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Bucur, A. and Bencko, V. and Foretova, L. and Janout, V. and Boffetta, P. and Colt, J.S. and Davis, F.G. and Schwartz, K.L. and Banks, R.E. and Selby, P.J. and Harnden, P. and Hsing, A.W. and Grubb, R.L., III and Boeing, H. and Vineis, P. and Clavel-Chapelon, F. and Palli, D. and Tumino, R. and Krogh, V. and Panico, S. and Duell, E.J. and Quirós, J.R. and Sanchez, M.-J. and Navarro, C. and Ardanaz, E. and Dorronsoro, M. and Khaw, K.-T. and Allen, N.E. and Bueno-de-Mesquita, H.B. and Peeters, P.H.M. and Trichopoulos, D. and Linseisen, J. and Ljungberg, B. and Overvad, K. and Tjønneland, A. and Romieu, I. and Mukeria, A. and Shangina, O. and Stevens, V.L. and Gapstur, S.M. and Pharoah, P.D. and Easton, D.F. and Njølstad, I. and Tell, G.S. and Stoltenberg, C. and Kumar, R. and Koppova, K. and Benhamou, S. and Oosterwijk, E. and Vermeulen, S.H. and Aben, K.K.H. and Van Der Marel, S.L. and Ye, Y. and Wood, C.G. and Pu, X. and Mazur, A.M. and Boulygina, E.S. and Chekanov, N.N. and Foglio, M. and Lechner, D. and Gut, I. and Heath, S. and Blanche, H. and Skryabin, K.G. and McKay, J.D. and Rothman, N. and Lathrop, M. and Brennan, P. and Saunders, B. and Thomas, H. and Clark, S. and Tomlinson, I.
Subjects: Male, pathogenesi, genetic association, phenotype, Adenomatous Polyposis Coli Protein, colorectal cancer, Colorectal Neoplasm, cancer risk, gene frequency, Polymorphism, Single Nucleotide, Article, DNA glycosyltransferase, adult, DNA glycosylase MutY, colon polyposi, single nucleotide polymorphism, genetic variability, middle aged, controlled study, Genetic Predisposition to Disease, human, DNA Glycosylase, Germ-Line Mutation, Aged, colorectal adenoma, Allele, modifier gene, Genes, Modifier, disease predisposition, APC protein, human, major clinical study, digestive system diseases, human tissue, APC protein, female, priority journal, Adenomatous Polyposis Coli, germline mutation, familial colon polyposi, adenoma, single nucleotide polymorphism, Adenoma, genetic, genetic predisposition
Abstract: The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). We investigated whether 18 common colorectal cancer (CRC) predisposition single-nucleotide polymorphisms (SNPs) could help to explain some cases with multiple adenomas who phenocopied FAP or MAP, but had no pathogenic APC or MUTYH variant. No multiple adenoma case had an outlying number of CRC SNP risk alleles, but multiple adenoma patients did have a significantly higher number of risk alleles than population controls (P = 5.7 × 10-7). The association was stronger in those with ≥ 10 adenomas. The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation. In FAP patients, the CRC risk score did not differ significantly from the controls, as we expected given the overwhelming effect of pathogenic germline APC variants on the phenotype of these cases. More unexpectedly, we found no evidence that the CRC SNPs act as modifier genes for the number of colorectal adenomas in FAP patients. In conclusion, common colorectal tumour risk alleles contribute to the development of multiple adenomas in patients without pathogenic germline APC or MUTYH variants. This phenotype may have 'polygenic' or monogenic origins. The risk of CRC in relatives of multiple adenoma cases is probably much lower for cases with polygenic disease, and this should be taken into account when counselling such patients. © 2015 Macmillan Publishers Limited All rights reserved.
Published: 2015

3. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Author: Lesseur, C. Diergaarde, B. Olshan, A.F. Wünsch-Filho, V. Ness, A.R. Liu, G. Lacko, M. Eluf-Neto, J. Franceschi, S. Lagiou, P. Macfarlane, G.J. Richiardi, L. Boccia, S. Polesel, J. Kjaerheim, K. Zaridze, D. Johansson, M. Menezes, A.M. Curado, M.P. Robinson, M. Ahrens, W. Canova, C. Znaor, A. Castellsagué, X. Conway, D.I. Holcátová, I. Mates, D. Vilensky, M. Healy, C.M. Szeszenia-Dabrowska, N. Fabiánová, E. Lissowska, J. Grandis, J.R. Weissler, M.C. Tajara, E.H. Nunes, F.D. De Carvalho, M.B. Thomas, S. Hung, R.J. Peters, W.H.M. Herrero, R. Cadoni, G. Bueno-De-Mesquita, H.B. Steffen, A. Agudo, A. Shangina, O. Xiao, X. Gaborieau, V. Chabrier, A. Anantharaman, D. Boffetta, P. Amos, C.I. McKay, J.D. Brennan, P.
Abstract: We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10 â'8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci - 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1∗1301-HLA-DQA1∗0103-HLA-DQB1∗0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers. © 2016 Nature America, Inc. part of Springer Nature, All Rights reserved.
Published: 2016

4. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author: Conway, D.I. Brenner, D.R. McMahon, A.D. Macpherson, L.M.D. Agudo, A. Ahrens, W. Bosetti, C. Brenner, H. Castellsague, X. Chen, C. Curado, M.P. Curioni, O.A. Maso, L.D. Daudt, A.W. De Gois Filho, J.F. D'Souza, G. Edefonti, V. Fabianova, E. Fernandez, L. Franceschi, S. Gillison, M. Hayes, R.B. Healy, C.M. Herrero, R. Holcatova, I. Jayaprakash, V. Kelsey, K. Kjaerheim, K. Koifman, S. La Vecchia, C. Lagiou, P. Lazarus, P. Levi, F. Lissowska, J. Luce, D. Macfarlane, T.V. Mates, D. Matos, E. McClean, M. Menezes, A.M. Menvielle, G. Merletti, F. Morgenstern, H. Moysich, K. Müller, H. Muscat, J. Olshan, A.F. Purdue, M.P. Ramroth, H. Richiardi, L. Rudnai, P. Schantz, S. Schwartz, S.M. Shangina, O. Simonato, L. Smith, E. Stucker, I. Sturgis, E.M. Szeszenia-Dabrowska, N. Talamini, R. Thomson, P. Vaughan, T.L. Wei, Q. Winn, D.M. Wunsch-Filho, V. Yu, G.-P. Zhang, Z.-F. Zheng, T. Znaor, A. Boffetta, P. Chuang, S.-C. Ghodrat, M. Lee, Y.-C.A. Hashibe, M. Brennan, P.
Abstract: Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR 5 2.50; 95% CI 5 2.02-3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR 5 1.61; 95% CI 5 1.13-2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels. © 2014 UICC.
Published: 2015

5. Genome-wide association study of renal cell carcinoma identifiestwo susceptibility loci on 2p21 and 11q13.3

Author: Purdue MP, Johansson M, Zelenika D, Toro JR, Scelo G, Moore LE, Prokhortchouk E, Wu X, Kiemeney LA, Gaborieau V, Jacobs KB, Chow WH, Zaridze D, Matveev V, Lubinski J, Trubicka J, Szeszenia Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL 3rd, Boeing H, Vineis P, Clavel Chapelon F, Palli D, Tumino R, Krogh V, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno de Mesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Mukeria A, Shangina O, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Weinstein SJ, Virtamo J, Vatten L, Hveem K, Njølstad I, Tell GS, Stoltenberg C, Kumar R, Koppova K, Cussenot O, Benhamou S, Oosterwijk E, Vermeulen SH, Aben KK, van der Marel SL, Ye Y, Wood CG, Pu X, Mazur AM, Boulygina ES, Chekanov NN, Foglio M, Lechner D, Gut I, Heath S, Blanche H, Hutchinson A, Thomas G, Wang Z, Yeager M, Fraumeni JF Jr, Skryabin KG, McKay JD, Rothman N, Chanock SJ, Lathrop M, Brennan P., PANICO, SALVATORE, Purdue, Mp, Johansson, M, Zelenika, D, Toro, Jr, Scelo, G, Moore, Le, Prokhortchouk, E, Wu, X, Kiemeney, La, Gaborieau, V, Jacobs, Kb, Chow, Wh, Zaridze, D, Matveev, V, Lubinski, J, Trubicka, J, Szeszenia Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Bucur, A, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Colt, J, Davis, Fg, Schwartz, Kl, Banks, Re, Selby, Pj, Harnden, P, Berg, Cd, Hsing, Aw, Grubb RL, 3rd, Boeing, H, Vineis, P, Clavel Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, Salvatore, Duell, Ej, Quirós, Jr, Sanchez, Mj, Navarro, C, Ardanaz, E, Dorronsoro, M, Khaw, Kt, Allen, Ne, Bueno de Mesquita, Hb, Peeters, Ph, Trichopoulos, D, Linseisen, J, Ljungberg, B, Overvad, K, Tjønneland, A, Romieu, I, Riboli, E, Mukeria, A, Shangina, O, Stevens, Vl, Thun, Mj, Diver, Wr, Gapstur, Sm, Pharoah, Pd, Easton, Df, Albanes, D, Weinstein, Sj, Virtamo, J, Vatten, L, Hveem, K, Njølstad, I, Tell, G, Stoltenberg, C, Kumar, R, Koppova, K, Cussenot, O, Benhamou, S, Oosterwijk, E, Vermeulen, Sh, Aben, Kk, van der Marel, Sl, Ye, Y, Wood, Cg, Pu, X, Mazur, Am, Boulygina, E, Chekanov, Nn, Foglio, M, Lechner, D, Gut, I, Heath, S, Blanche, H, Hutchinson, A, Thomas, G, Wang, Z, Yeager, M, Fraumeni JF, Jr, Skryabin, Kg, Mckay, Jd, Rothman, N, Chanock, Sj, Lathrop, M, and Brennan, P.
Published: 2011

6. A genome-wide association study of upperaerodigestive tract cancers conducted within the INHANCE consortium

Author: McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel Chapelon F, Palli D, Tumino R, Krogh V, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno de Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Vooder T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P., PANICO, SALVATORE, Mckay, Jd, Truong, T, Gaborieau, V, Chabrier, A, Chuang, Sc, Byrnes, G, Zaridze, D, Shangina, O, Szeszenia Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Bucur, A, Bencko, V, Holcatova, I, Janout, V, Foretova, L, Lagiou, P, Trichopoulos, D, Benhamou, S, Bouchardy, C, Ahrens, W, Merletti, F, Richiardi, L, Talamini, R, Barzan, L, Kjaerheim, K, Macfarlane, Gj, Macfarlane, Tv, Simonato, L, Canova, C, Agudo, A, Castellsagué, X, Lowry, R, Conway, Di, Mckinney, Pa, Healy, Cm, Toner, Me, Znaor, A, Curado, Mp, Koifman, S, Menezes, A, Wünsch Filho, V, Neto, Je, Garrote, Lf, Boccia, S, Cadoni, G, Arzani, D, Olshan, Af, Weissler, Mc, Funkhouser, Wk, Luo, J, Lubiński, J, Trubicka, J, Lener, M, Oszutowska, D, Schwartz, Sm, Chen, C, Fish, S, Doody, Dr, Muscat, Je, Lazarus, P, Gallagher, Cj, Chang, Sc, Zhang, Zf, Wei, Q, Sturgis, Em, Wang, Le, Franceschi, S, Herrero, R, Kelsey, Kt, Mcclean, Md, Marsit, Cj, Nelson, Hh, Romkes, M, Buch, S, Nukui, T, Zhong, S, Lacko, M, Manni, Jj, Peters, Wh, Hung, Rj, Mclaughlin, J, Vatten, L, Njølstad, I, Goodman, Ge, Field, Jk, Liloglou, T, Vineis, P, Clavel Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, Salvatore, González, Ca, Quirós, Jr, Martínez, C, Navarro, C, Ardanaz, E, Larrañaga, N, Khaw, Kt, Key, T, Bueno de Mesquita, Hb, Peeters, Ph, Trichopoulou, A, Linseisen, J, Boeing, H, Hallmans, G, Overvad, K, Tjønneland, A, Kumle, M, Riboli, E, Välk, K, Vooder, T, Metspalu, A, Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Blanché, H, Gut, Ig, Galan, P, Heath, S, Hashibe, M, Hayes, Rb, Boffetta, P, Lathrop, M, and Brennan, P.
Published: 2011

7. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

Author: Horwitz, M.S., McKay, J.D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S.-C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Agudo, A., Castellsagué, X., Lowry, R., Conway, D.I., McKinney, P.A., Healy, C.M., Toner, M.E., Znaor, A., Curado, M.P., Koifman, S., Menezes, A., Wünsch-Filho, V., Neto, J.E., Garrote, L.F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A.F., Weissler, M.C., Funkhouser, W.K., Luo, J., Lubiński, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S.M., Chen, C., Fish, S., Doody, D.R., Muscat, J.E., Lazarus, P., Gallagher, C.J., Chang, S.C., Zhang, Z.F., Wei, Q., Sturgis, E.M., Wang, L.E., Franceschi, S., Herrero, R., Kelsey, K.T., McClean, M.D., Marsit, C.J., Nelson, H.H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J.J., Peters, W.H.M., Hung, R.J., McLaughlin, J., Vatten, L., Njølstad, I., Goodman, G.E., Field, J.K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., González, C.A., Quirós, J.R., Martínez, C., Navarro, C., Ardanaz, E., Larrañaga, N., Khaw, K.T., Key, T., Bueno-de-Mesquita, H. B., Peeters, P.H.M., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad, K., Tjønneland, A., Kumle, M., Riboli, E., Välk, K., Vooder, T., Metspalu, A., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Blanché, H., Gut, I.G., Galan, P., Heath, S., Hashibe, M., Hayes, R.B., Boffetta, P., Lathrop, M., and Brennan, P.
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Published: 2011

8. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

Author: McKay, J.D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S.C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Agudo, A., Castellsague, X., Lowry, R., Conway, D.I., McKinney, P.A., Healy, C.M., Toner, M.E., Znaor, A., Curado, M.P., Koifman, S., Menezes, A., Wunsch-Filho, V., Neto, J.E., Garrote, L.F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A.F., Weissler, M.C., Funkhouser, W.K., Luo, J., Lubinski, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S.M., Chen, C., Fish, S., Doody, D.R., Muscat, J.E., Lazarus, P., Gallagher, C.J., Chang, S.C., Zhang, Z.F., Wei, Q., Sturgis, E.M., Wang, L.E., Franceschi, S., Herrero, R., Kelsey, K.T., McClean, M.D., Marsit, C.J., Nelson, H.H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J.J., Peters, W.H.M., Hung, R.J., McLaughlin, J., Vatten, L., Njolstad, I., Goodman, G.E., Field, J.K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Gonzalez, C.A., Quiros, J.R., Martinez, C., Navarro, C, Ardanaz, E., and Larrañaga, N.
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p
Published: 2011

9. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

Author: McKay, J.D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S.C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Agudo, A., Castellsague, X., Lowry, R., Conway, D.I., McKinney, P.A., Healy, C.M., Toner, M.E., Znaor, A., Curado, M.P., Koifman, S., Menezes, A., Wunsch-Filho, V., Neto, J.E., Garrote, L.F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A.F., Weissler, M.C., Funkhouser, W.K., Luo, J., Lubinski, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S.M., Chen, C., Fish, S., Doody, D.R., Muscat, J.E., Lazarus, P., Gallagher, C.J., Chang, S.C., Zhang, Z.F., Wei, Q., Sturgis, E.M., Wang, L.E., Franceschi, S., Herrero, R., Kelsey, K.T., McClean, M.D., Marsit, C.J., Nelson, H.H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J.J., Peters, W.H.M., Hung, R.J., McLaughlin, J., Vatten, L., Njolstad, I., Goodman, G.E., Field, J.K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Gonzalez, C.A., Quiros, J.R., Martinez, C., Navarro, C, Ardanaz, E., and Larrañaga, N.
Subjects: Molecular gastro-enterology and hepatology Translational research [IGMD 2]
Abstract: Contains fulltext : 96576.pdf (Publisher’s version ) (Open Access) Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p
Published: 2011

10. [Risk factors of laryngeal cancer in Central and Eastern Europe]

Author: Shangina, O. V., Sdvizhkov, A. M., Kozhanov, L. G., Finkelstern, M. R., Brennan, P., Boffetta, P., Zaridze, D. G., Shangina, O.V., Sdvizhkov, A.M., Kozhanov, L.G., Finkelstern, M.R., Brennan, P., Boffetta, P., and Zaridze, D.G.
Subjects: Male, Alcohol Drinking, Risk Factors, Case-Control Studies, Occupational Exposure, Risk factors laryngeal cancer Central Eastern Europe, Smoking, Humans, Female, Europe, Eastern, Coal Mining, Laryngeal Neoplasms
Abstract: A case-control epidemiologic study in squamous-cell carcinoma of the larynx (LC) vs. smoking was carried out. Although no independent influence of drinking was found, the synergetic effect of the two habits potentiated the carcinogenic impact. Approximately 87% of LC cases are attributable to tobacco use in Central and Eastern Europe. Occupational exposure to coal dust is regarded as a possible cause.
Published: 2008

11. Multiple ADH genes are associated with upper aerodigestive cancers

Author: Hashibe, M., McKay, J.D., Curado, M.P., Oliveira, J.C., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V., Eluf-Neto, J., Levi, J.E., Matos, E., Lagiou, P., Lagiou, E., Benhamou, S., Bouchardy, C., Szeszenia-Dabrowska, N., Menezes, A., Dall&#8217, Agnol, M.M., Merletti, F., Richiardi, L., Fernandez, L., Lence, J., Talamini, R., Barzan, L., Mates, D., Mates, I.N., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Holcatova, I., Agudo, A., Castellsague, X., Lowry, R., Janout, V., Kollarova, H., Conway, D.I., McKinney, P.A., Znaor, Ariana, Fabianova, E., Bencko, V., Lissowska, J., Chabrier, A., Hung, R.J., Gaborieau, V., Boffetta, P., and Brennan, P.
Subjects: ADH genes, upper aerodigestive cancers
Abstract: Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3, 800 aerodigestive cancer cases and 5, 200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
Published: 2008

12. CELL TECHNOLOGIES, TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Author: Babenko, V. A., Silachev, D. N., Goryunov, K., Pevzner, I. B., Popkov, V. A., Zorova, L. D., Plotnikov, E. Y., Zorov, D. B., Sukhikh, G. T., Belodedova, A., Antonova, O. P., Malyugin, B. E., Bol Shov, A., Akhmad, Y. A., Tret Yak, S., Khryshchanovich, V. Y., Borzenok, S. A., Tonayeva, K. D., Ostrovskiy, D. S., Akhmedov, A. K., Kalinnikov, Y. Y., Gavrilova, N. A., Agapov, I. I., Revishchin, A., Tishchenko, O. E., Bobrova, M. M., Safonova, L. A., Agammedov, M. B., Pavlova, G., Gonikova, Z. Z., Nikol Skaya, A. O., Kirsanova, L. A., Shagidulin, M. Y., Onishchenko, N. A., Sevast Yanov, V., Granov, D. A., Sheraliyev, A. R., Polikarpov, A. A., Tileubergenov, I. I., Gerasimova, O. A., Moiseyenko, A., Polekhin, A. S., Raskin, G. A., Efimov, A. E., Agapova, O., Zhura, A., Kulikovskaya, V., Gilevskaya, K. S., Kraskovskiy, A. N., Agagbekov, V. E., Kerimov, T. Z., Zheltonozhko, A. A., Korotkov, S., Nosik, A., Primakova, E. A., Nazarova, E. A., Dedyulya, N., Buzuk, E. S., Petrovskaya, E. G., Yunova, Y. N., Dmitriyeva, M., Efimov, D. Y., Shturich, I. P., Pikirenya, I. I., Shcherba, A. E., Kalachik, O., Krivenko, S., Rummo, O. O., Kuznetsova, E. G., Kuryleva, O. M., Salomatina, L. A., Kulikov, A., Arkhipova, L., Gavrilyuk, V. B., Mndlyan, E. Y., Rudnev, V. R., Glazkova, P. A., Glazkov, A. A., Kulikov, D. A., Lokhonina, A., Nikitina, M. P., El Chaninov, A., Fatkhudinov, T. K., Gelyastanov, A. M., Nemets, E. A., Pankina, A. P., Symanovich, A. A., Savchenkova, I. P., Savchenkova, E. A., Salikhova, D., Georgiy Leonov, Namestnikova, D. D., Bulatenko, N., Gubskiy, I. L., Bukharova, T. B., Sukhinich, K. K., Mel Nikov, P. A., Cherkashova, E. A., Gubskiy, L., Yarygin, K. N., Gol Dshteyn, D., Fomichev, A., Chernyavskiy, A. M., Gulyayeva, K. K., Poveshchenko, O., Kareva, Y. E., Minin, S. M., Nikitin, N. A., Antonova, L., Senokosova, E. A., Sil Nikov, V. N., Krivkina, E. O., Kudryavtseva, Y. A., Barbarash, L. S., Basok, Y. B., Grigor Yev, A. M., Kirillova, A. D., Kovalev, A., Lebedeva, A., Muslimov, S. A., Shangina, O. R., Afanas Yev, S. A., Kondrat Yeva, D. S., Popov, S., Nigmatullin, R. T., Kutushev, R. Z., Motygullin, B. R., Mukhametova, D. A., Ponomareva, A. S., Miloserdov, I. A., Sergeyeva, N. S., Khesuani, Y. D., Kirsanova, V. A., Karalkin, P. A., Sviridova, I. K., Polyakov, P. A., Skaletskaya, G. N., Skaletskiy, N. N., and Bubentsova, G. N.

13. Correction: A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Author: Jd, Mckay, Therese Truong, Gaborieau V, Chabrier A, Chuang S, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, and Brennan P

14. Correction: A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Author: Jd, Mckay, Truong T, Gaborieau V, Chabrier A, Chuang S, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, and Benhamou S

15. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author: Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J., Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A., Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark P., Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N., Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y.-C.A., Hashibe M., Boffetta P., Conway D.I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S.-C., Curado M.P., Dal Maso L., Daudt A.W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N.D., Hayes R.B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G.J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R.A., Moysich K., Muscat J., Negri E., Olshan A.F., Pandics T., Polesel J., Purdue M.P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S.M., Serraino D., Shangina O., Smith E., Sturgis E.M., Swiatkowska B., Thomson P., Toporcov T.N., Vaughan T.L., Vilensky M., Winn D.M., Wunsch-Filho V., Yu G.-P., Zevallos J.P., Zhang Z.-F., Zheng T., and Znaor A.
Subjects: INHANCE, medicine.medical_specialty, Oral health, Cancer recurrence, Article, Tobacco Use, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, pooled analysi, prognostic factor, General Dentistry, Beneficial effects, Head and Neck Neoplasm, business.industry, Incidence (epidemiology), Head and neck cancer, oral cavity cancer, Case-control study, prognostic factors, 030206 dentistry, medicine.disease, risk factor, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, 030220 oncology & carcinogenesis, Family medicine, Etiology, laryngeal cancer, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, Neoplasm Recurrence, Local, Case-Control Studie, business, Human
Abstract: Objective:\ud \ud To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.\ud \ud Subjects and Methods:\ud \ud INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview.\ud \ud Results:\ud \ud Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively.\ud \ud Conclusions:\ud \ud The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.
Published: 2020

16. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author: Philip Lazarus, Claire M. Healy, Richard B. Hayes, Rolando Herrero, Elaine M. Smith, Stefania Boccia, Leonardo F. Boaventura Rios, Paolo Boffetta, Dana Mates, Jerry Polesel, Marta Vilensky, Jose P. Zevallos, Diego Serraino, Gypsyamber D'Souza, Joshua E. Muscat, Kirsten B. Moysich, Yuan Chin Amy Lee, Mark P. Purdue, Carlo La Vecchia, Heribert Ramroth, Thomas L. Vaughan, Peter Thomson, Karl T. Kelsey, Nicola Torelli, Wolfgang Ahrens, Hermann Brenner, Lorenzo Richiardi, Victor Wünsch-Filho, Kristina Kjærheim, Beata Swiatkowska, Keitaro Matsuo, Fabio Levi, Erich M. Sturgis, Eva Negri, Lorenzo Simonato, Danièle Luce, Guo Pei Yu, Chu Chen, Pagona Lagiou, Silvia Franceschi, Andrew F. Olshan, Alexander W. Daudt, Antonio Agudo, Maria Paula Curado, Peter Rudnai, Tatiana V. Macfarlane, Zuo-Feng Zhang, Mia Hashibe, Paul Brennan, Tatiana Natasha Toporcov, Stimson P. Schantz, Maura L. Gillison, Isabelle Stücker, Tongzhang Zheng, Shu Chun Chuang, Oxana Shangina, Eleonora Fabianova, Hal Morgenstern, David I. Conway, Valeria Edefonti, Cristina Bosetti, Ariana Znaor, Leticia Fernandez, Michael D. McClean, Luigino Dal Maso, Neil D. Gross, Stephen M. Schwartz, Ivana Holcatova, Guojun Li, Ana M. B. Menezes, Francesco Pauli, Gioia Di Credico, Deborah M. Winn, Rosalina Jorge Koifman, Gwenn Menvielle, Gabriella Cadoni, Werner Garavello, Jolanda Lissowska, Università degli Studi di Milano [Milano] (UNIMI), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Glasgow, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TW001500, National Institutes of Health, P30ES010126, National Institute of Environmental Health Sciences, Italian Ministry of Education, Università degli Studi di Milano, Jonsson Comprehensive Cancer Center, International Union Against Cancer, Fondo para la Investigacion Cientifica y Tecnologica Argentina, Institut Hospital del Mar d’Investigacions Mediquès (IMIM), Fundação de Amparo à Pesquisa no Estado de São Paulo, Spanish Government, European Community, Ministry of Science, Research and Arts Baden-Wurttemberg, German Ministry of Education and Research, Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Labor and Welfare of Japan, Italian Foundation for Cancer Research, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A.W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D.I., Macfarlane T.V., Thomson P., Agudo A., Znaor A., Boaventura Rios L.F., Toporcov T.N., Franceschi S., Herrero R., Muscat J., Olshan A.F., Zevallos J.P., La Vecchia C., Winn D.M., Sturgis E.M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z.-F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S.M., Vaughan T.L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R.B., Purdue M., Gillison M., Schantz S., Yu G.-P., Brenner H., D'Souza G., Gross N.D., Chuang S.-C., Boffetta P., Hashibe M., Lee Y.-C.A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W., Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I., Macfarlane, Tatiana V., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F., Toporcov, Tatiana N., Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F., Zevallos, Jose P., La Vecchia, Carlo, Winn, Deborah M., Sturgis, Erich M., Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, Mcclean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Vaughan, Thomas L., Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B., Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D., Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Università degli Studi di Milano = University of Milan (UNIMI), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Subjects: Male, Oral cavity and pharyngeal cancers, Cancer Research, Bivariate spline model, medicine.medical_treatment, Logistic regression, Substance Misuse, 0302 clinical medicine, Risk Factors, Laryngeal cancer, 80 and over, 2.2 Factors relating to the physical environment, Aetiology, 030223 otorhinolaryngology, Head and neck cancer, Cancer, Aged, 80 and over, Confounding, Middle Aged, 3. Good health, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Public Health and Health Services, Female, Oral Surgery, Adult, INHANCE, Oncology and Carcinogenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bivariate analysis, Cigarette Smoking, 03 medical and health sciences, Rare Diseases, Clinical Research, Tobacco, medicine, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Aged, Settore MED/06 - ONCOLOGIA MEDICA, Tobacco Smoke and Health, business.industry, Prevention, Case-control study, Odds ratio, medicine.disease, Former Smoker, Good Health and Well Being, Case-Control Studies, Dentistry, Smoking cessation, business, Demography
Abstract: Objectives: \ud This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.\ud \ud Materials and Methods: \ud We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.\ud \ud Results: \ud For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.\ud \ud Conclusion: \ud Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
Published: 2019

17. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Author: J. Ramón Quirós, Eva Ardanaz, Stefania Boccia, Wilbert H.M. Peters, Dimitrios Trichopoulos, Mario Foglio, Luigi Barzan, Lenka Foretova, Joshua E. Muscat, Françoise Clavel-Chapelon, Elio Riboli, Diana Zelenika, Paul Brennan, Salvatore Panico, Eleonora Fabianova, Lars J. Vatten, Kay-Tee Khaw, David I. Conway, Pilar Galan, Doris Lechner, Erich M. Sturgis, Shilong Zhong, Shama Buch, Jolanta Lissowska, Franco Merletti, Carmen Enid Martínez, Li E. Wang, H. Bas Bueno-de-Mesquita, Vittorio Krogh, Andres Metspalu, Anne Tjønneland, Shen Chih Chang, Rayjean J. Hung, Silvia Franceschi, Amelie Chabrier, Kristina Kjærheim, Gabriella Cadoni, Sergio Koifman, Ariana Znaor, Chu Chen, Pagona Lagiou, Ivana Holcatova, Richard B. Hayes, James McKay, Graham Byrnes, Philip Lazarus, Christine Bouchardy, Ray Lowry, Vladimir Bencko, Merethe Kumle, Jingchun Luo, Antonio Agudo, Mark Lathrop, David R. Doody, Victor Wünsch-Filho, Joanna Trubicka, Lorenzo Simonato, Martin Lacko, Cristina Canova, John K. Field, Sherianne Fish, Valerie Gaborieau, Xavier Castellsagué, Mary Toner, Thérèse Truong, Tomoko Nukui, Carla J. Gallagher, Wolfgang Ahrens, Triantafillos Liloglou, Kim Overvad, Vladimir Janout, Ivo Gut, Paolo Boffetta, Shu Chun Chuang, Göran Hallmans, Jakob Linseisen, Marjorie Romkes, David Zaridze, Mark C. Weissler, Simone Benhamou, Antonia Trichopoulou, Nerea Larrañaga, José Eluf Neto, Neonila Szeszenia-Dabrowska, Jan Lubinski, Stephen M. Schwartz, Peter Rudnai, Hélène Blanché, Mia Hashibe, William K. Funkhouser, Paolo Vineis, Maria Paula Curado, Gary J. Macfarlane, Marcin Lener, Claire M. Healy, Michael D. McClean, Domenico Palli, Marc Delepine, Tõnu Voodern, Carmen J. Marsit, Zuo-Feng Zhang, Kristjan Välk, Dorota Oszutowska, Heiner Boeing, Ana M. B. Menezes, Rolando Herrero, Leticia Fernández Garrote, Heather H. Nelson, Renato Talamini, Anne Boland, Alexandru Bucur, Qingyi Wei, Gary E. Goodman, Lorenzo Richiardi, Carmen Navarro, Karl T. Kelsey, Rosario Tumino, Inger Njølstad, Johannes J. Manni, Carlos A. González, Oxana Shangina, John R. McLaughlin, Patricia A. McKinney, Timothy J. Key, Andrew F. Olshan, Dario Arzani, Tatiana V. Macfarlane, Simon Heath, Petra H.M. Peeters, International Agency for Research on Cancer (IARC), Russian Academy of Medical Sciences, Department of Epidemiology, Institute of Occupational Medicine, Maria Skłodowska Curie Memorial Cancer Center, National Institute for Environment, Partenaires INRAE, Regional Authority of Public Health, Institute of Public Health, Charles University [Prague] (CU), Palacky University Olomouc, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute (RECAMO), National and Kapodistrian University of Athens (NKUA), The Netherlands Cancer Institute, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Stabilité Génétique et Oncogenèse (UMR 8200), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), Bremen Institute for Prevention Research and Social Medicine (BIPS), University of Bremen, Universita di Torino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), General Hospital, Cancer Registry of Norway, School of Medicine and Dentistry, Universita di Padova, Imperial College London, Catalan Institute of Oncology, CIBER de Epidemiología y Salud Pública (CIBERESP), Newcastle University [Newcastle], Dental School, Centre for Epidemiology and Biostatistics, University of Leeds, NHS NSS ISD, School of Dental Science, University of Liverpool, National Institute of Public Health, National School of Public Health, Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Universidade de São Paulo (USP), Institute of Oncology and Radiobiology, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Institute of Hygiene, Università cattolica del Sacro Cuore [Milano] (Unicatt), University of North Carolina, Pomeranian Medical University, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Penn State College of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of California [Los Angeles] (UCLA), University of California, Anderson Cancer Center, The University of Texas Health Science Center at Houston (UTHealth), Instituto de Investigación Epidemiológica, Brown University, School of public health, The University of Hong Kong (HKU), Masonic Cancer Center, University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, University of Pittsburgh (DEPARTMENT OF MATHEMATICS), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Maastricht University [Maastricht], Radboud University Medical Center [Nijmegen], Mount Sinai Hospital [Toronto, Canada] (MSH), Cancer Care Ontario, Norwegian University of Science and Technology (NTNU), University of Tromsø (UiT), Piedmont Reference Center for Epidemiology and Cancer Prevention, Department of Epidemiology and Public Health, Institut National de la Santé et de la Recherche Médicale (INSERM), Istituto per lo Studio e la Prevezione Oncologica, Civile - M.P.Arezzo Hospital, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), INCa, France, US NCI [R01 CA092039 05/05S1], Benhamou, Simone, Bouchardy Magnin, Christine, Charles University in Prague, Università cattolica del Sacro Cuore [Roma] (Unicatt), Penn State System-Pennsylvania Commonwealth System of Higher Education (PCSHE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), [McKay, JD, Truong, T, Gaborieau, V, Chabrier, A, Chuang, SC, Byrnes, G, Curado, MP, Franceschi, S, Hashibe, M, Boffetta, P, Brennan, P] IARC, Lyon, France. [Zaridze, D, Shangina, O] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow, Russia. [Szeszenia-Dabrowska, N] Inst Occupat Med, Dept Epidemiol, Lodz, Poland. [Lissowska, J] M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland. [Lissowska, J] Inst Oncol, Warsaw, Poland. [Rudnai, P] Natl Inst Environm Hlth, Budapest, Hungary. [Fabianova, E] Reg Author Publ Hlth, Banska Bystrica, Slovakia. [Bucur, A] Inst Publ Hlth, Bucharest, Romania. [Bencko, V, Holcatova, I] Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic. [Janout, V] Palacky Univ, CR-77147 Olomouc, Czech Republic. [Foretova, L] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic. [Trichopoulos, D] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Benhamou, S] INSERM U946, Paris, France. [Benhamou, S] Inst Gustave Roussy, CNRS UMR8200, Villejuif, France. [Bouchardy, C] Univ Geneva, Geneva Canc Registry, Inst Social & Prevent Med, Geneva, Switzerland. [Ahrens, W] Univ Bremen, Bremen Inst Prevent Res & Social Med BIPS, Bremen, Germany. [Merletti, F, Richiardi, L] Univ Turin, Canc Epidemiol Unit, Turin, Italy. [Talamini, R] IRCCS, Natl Canc Inst, Aviano, Italy. [Barzan, L] Gen Hosp Pordenone, Pordenone, Italy. [Kjaerheim, K] Canc Registry Norway, Oslo, Norway. [Macfarlane, GJ, Macfarlane, TV] Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland. [Simonato, L, Canova, C] Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy. [Canova, C] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England. [Agudo, A, Castellsague, X] ICO, Barcelona, Spain. [Castellsague, X, Navarro, C, Ardanaz, E] CIBERESP, Madrid, Spain. [Lowry, R] Univ Newcastle Dent Sch, Newcastle Upon Tyne, Tyne & Wear, England. [Conway, DI] Univ Glasgow Dent Sch, Glasgow, Lanark, Scotland. [McKinney, PA] Univ Leeds Ctr Epidemiol & Biostat, Leeds, W Yorkshire, England. [McKinney, PA] NHS NSS ISD, Edinburgh, Midlothian, Scotland. [Healy, CM, Toner, ME] Trinity Coll Sch Dent Sci, Dublin, Ireland. [Znaor, A] Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia. [Koifman, S] Natl Sch Publ Hlth FIOCRUZ, Rio De Janeiro, Brazil. [Menezes, A] Univ Fed Pelotas, Pelotas, Brazil. [Wuensch, V, Neto, JE] Univ Sao Paulo, Sao Paulo, Brazil. [Garrote, LF] Inst Oncol & Radiobiol, Havana, Cuba. [Boccia, S, Cadoni, G, Arzani, D] Univ Cattolica Sacro Cuore, Inst Hyg, Rome, Italy. [Boccia, S] IRCCS San Raffaele Pisana, Rome, Italy. [Olshan, AF] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Weissler, MC, Funkhouser, WK, Luo, JC] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Lubinski, J, Trubicka, J, Lener, M, Oszutowska, D] Pomeranian Med Univ, Dept Genet & Pathomorphol, Int Hereditary Canc Ctr, Szczecin, Poland. [Oszutowska, D] Pomeranian Med Univ, Dept Hyg Epidemiol & Publ Hlth, Szczecin, Poland. [Schwartz, SM, Chen, C, Fish, S, Doody, DR, Goodman, GE] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Muscat, JE, Lazarus, P, Gallagher, CJ] Penn State Coll Med, Hershey, PA USA. [Chang, SC, Zhang, ZF] Univ Calif Los Angeles Sch Publ Hlth, Los Angeles, CA USA. [Wei, QY, Sturgis, EM, Wang, LE] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Herrero, R] Inst Invest Epidemiol, San Jose, Costa Rica. [Kelsey, KT, Marsit, CJ] Brown Univ, Providence, RI 02912 USA. [McClean, MD] Boston Univ Sch Publ Hlth, Boston, MA USA. [Nelson, HH] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA. [Romkes, M, Buch, S, Nukui, T, Zhong, SL] Univ Pittsburgh, Pittsburgh, PA USA. [Lacko, M, Manni, JJ] Maastricht Univ Med Ctr, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands. [Peters, WHM] St Radboud Univ Nijmegen Med Ctr, Dept Gastroenterol, Nijmegen, Netherlands. [Hung, RJ] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [McLaughlin, J] Canc Care Ontario, Toronto, ON, Canada. [Vatten, L] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway. [Njolstad, I] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway. [Field, JK, Liloglou, T] Univ Liverpool Canc Res Ctr, Roy Castle Lung Canc Res Programme, Liverpool, Merseyside, England. [Vineis, P] Univ Turin, Serv Epidemiol Tumori, Turin, Italy. [Vineis, P] CPO Piemonte, Turin, Italy. [Vineis, P, Riboli, E] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Clavel-Chapelon, F] E3N EPIC Grp Inst Gustave Roussy, INSERM, Villejuif, France. [Palli, D] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Histopathol Unit, Ragusa, Italy. [Krogh, V] Fdn IRCCS, Ist Nazl Tumori, Milan, Italy. [Panico, S] Univ Naples Federico 2, Dipartimento Med Clin & Sperimentale, Naples, Italy. [Gonzalez, CA] ICO, RETICC DR06 0020, IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain. [Quiros, JR] Principado Asturias, Consejeria Serv Sociales, Jefe Secc Informac Sanitaria, Oviedo, Spain. [Martinez, C] Escuela Andaluza Salud Publ, Granada, Spain. [Navarro, C] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain. [Ardanaz, E] Navarra Publ Hlth Inst, Pamplona, Spain. [Larranaga, N] Gobierno Vasco, Subdirecc Salud Publ Gipuzkoa, San Sebastian, Spain. [Khaw, KT] Univ Cambridge, Sch Clin Med, Cambridge, England. [Key, T] Univ Oxford, Canc Res UK, Oxford, England. [Bueno-de-Mesquita, HB] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Peeters, PHM] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands. [Trichopoulou, A] Univ Athens Sch Med, WHO Collaborating Ctr Nutr, Dept Hyg Epidemiol & Med Stat, Athens, Greece. [Linseisen, J] Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany. [Linseisen, J] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany. [Boeing, H] Deutsch Inst Ernahrungsforsch, Dept Epidemiol, Potsdam, Germany. [Hallmans, G] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Overvad, K] Aarhus Univ, Dept Epidemiol & Social Med, Aarhus, Denmark. Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Kumle, M] Univ Hosp No Norway, Tromso, Norway. [Valk, K, Voodern, T, Metspalu, A] Univ Tartu, EE-50090 Tartu, Estonia. [Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Gut, IG, Heath, S, Lathrop, M] Commissariat Energie Atom, Inst Genom, Ctr Natl Genotypage, Evry, France. [Blanche, H, Lathrop, M] Fdn Jean Dausset CEPH, Paris, France. [Galan, P] Univ Paris 13, INSERM INRA CNAM U557 U1125, Bobigny, France. [Hayes, RB] New York Univ Langone Med Ctr, New York, NY USA, Support for the central Europe and ARCAGE genome-wide studies and follow-up genotyping was provided by INCa, France. Additional funding for study coordination, genotyping of replication studies, and statistical analysis was provided by the US NCI (R01 CA092039 05/05S1)., Norges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisin, McKay, J.D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S.-C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Agudo, A., Castellsagué, X., Lowry, R., Conway, D.I., McKinney, P.A., Healy, C.M., Toner, M.E., Znaor, A., Curado, M.P., Koifman, S., Menezes, A., Wünsch-Filho, V., Neto, J.E., Garrote, L.F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A.F., Weissler, M.C., Funkhouser, W.K., Luo, J., Lubinski, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S.M., Chen, C., Fish, S., Doody, D.R., Muscat, J.E., Lazarus, P., Gallagher, C.J., Chang, S.-C., Zhang, Z.-F., Wei, Q., Sturgis, E.M., Wang, L.-E., Franceschi, S., Herrero, R., Kelsey, K.T., McClean, M.D., Marsit, C.J., Nelson, H.H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J.J., Peters, W.H.M., Hung, R.J., McLaughlin, J., Vatten, L., Njølstad, I., Goodman, G.E., Field, J.K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., González, C.A., Quirós, J.R., Martínez, C., Navarro, C., Ardanaz, E., Larrañaga, N., Khaw, K.-T., Key, T., Bueno-de-Mesquita, H.B., Peeters, P.H.M., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad, K., Tjønneland, A., Kumle, M., Riboli, E., Välk, K., Voodern, T., Metspalu, A., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Blanché, H., Gut, I.G., Galan, P., Heath, S., Hashibe, M., Hayes, R.B., Boffetta, P., Lathrop, M., Brennan, P., Promovendi PHPC, Metamedica, KNO, RS: MHeNs School for Mental Health and Neuroscience, and RS: GROW - School for Oncology and Reproduction
Subjects: Male, Cancer Research, Candidate gene, Linkage disequilibrium, [SDV]Life Sciences [q-bio], Genome-wide association study, FAMILY-HISTORY, genome-wide, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [Medical Subject Headings], 0302 clinical medicine, Gene Frequency, NECK-CANCER, Risk Factors, Càncer, SUSCEPTIBILITY LOCUS, SENSITIVITY PROTEIN MUS308, Genetics (clinical), Cancer, Genetics & Heredity, Genetics, Publication Characteristics::Study Characteristics::Multicenter Study [Medical Subject Headings], 0303 health sciences, TOBACCO-RELATED CANCERS, Tumor, Continental Population Groups, Middle Aged, 3. Good health, LUNG-CANCER, POOLED ANALYSIS, EPIDEMIOLOGY CONSORTIUM, INTERNATIONAL HEAD, ALCOHOL-DRINKING, Head and Neck Neoplasms, Drinking of alcoholic beverages, 030220 oncology & carcinogenesis, NEOPLASIAS, Consum d'alcohol, Head and Neck Neoplasms/enzymology/epidemiology/genetics, Genetics and Genomics/Gene Discovery, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Life Sciences & Biomedicine, Medical Genetics, Research Article, Adult, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714, Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [Medical Subject Headings], lcsh:QH426-470, Neoplasias de Cabeza y Cuello, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714, Genetics and Genomics/Complex Traits, Biology, association study, Estudio de Asociación del Genoma Completo, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings], 03 medical and health sciences, upper aerodigestive tract, Genetic variation, Biomarkers, Tumor, medicine, cancers, cancer, Humans, Genetic Predisposition to Disease, ddc:610, Tumor Markers, Biological/genetics, Genetics and Genomics/Cancer Genetics, Molecular Biology, Genotyping, Allele frequency, Settore MED/42 - IGIENE GENERALE E APPLICATA, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Genetic association, ddc:613, Aged, Medicinsk genetik, Estudio Multicéntrico, Science & Technology, Racial Groups, Genetic Variation, Aldehyde Dehydrogenase, medicine.disease, lcsh:Genetics, Aldehyde Dehydrogenase/genetics, Genome-Wide Association Study, Persons::Persons::Population Groups::Continental Population Groups [Medical Subject Headings], INHANCE consortium, sensitivity protein mus308, tobacco-related cancers, lung-cancer, pooled analysis, susceptibility locus, neck-cancer, epidemiology consortium, international head, alcohol-drinking, family-history, INHANCE Consortium, Biomarkers, Genètica
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility., Author Summary We have used a two-phased study approach to identify common genetic variation involved in susceptibility to upper aero-digestive tract cancer. Using Illumina HumanHap300 beadchips, 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls, were genotyped for a panel 317,000 genetic variants that represent the majority of common genetic in the human genome. The 19 top-ranked variants were then studied in an additional series of 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies. Five variants were significantly associated with UADT cancer risk after the completion of both stages, including three residing within the alcohol dehydrogenase genes (ADH1B, ADH1C, ADH7) that have been previously described. Two additional variants were found, one near the ALDH2 gene and a second variant located in HEL308, a DNA repair gene. These results implicate two variants 4q21 and 12q24 and further highlight three ADH variants UADT cancer susceptibility.
Published: 2011

18. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer

Author: Neonila Szeszenia-Dabrowska, Dana Mates, Danièle Luce, Lorenzo Simonato, José Eluf-Neto, Michael Pawlita, Elaine M. Smith, Kim De Ruyck, Gwenn Menvielle, Cristina Bosetti, Deborah M. Winn, David Zaridze, Gabriella Cadoni, Keitaro Matsuo, Diego Serraino, Isabelle Stücker, Richard B. Hayes, Mia Hashibe, Andrew F. Olshan, Robert I. Haddad, David I. Conway, Guo-Pei Yu, Tatiana V. Macfarlane, Simone Benhamou, Chu Chen, Brenda Diergaarde, Maura L. Gillison, Paul Brennan, Michael D. McClean, Kristina Kjærheim, Vladimir Bencko, Peter Rudnai, Guojun Li, Eleonora Fabianova, Pagona Lagiou, Thomas L. Vaughan, Witold Zatonski, Silvia Franceschi, Gypsyamber D'Souza, Rayjean J. Hung, Victor Wünsch-Filho, Antonio Agudo, Yuan Chin Amy Lee, Martin Lacko, Erich M. Sturgis, Xavier Castellsagué, Fabio Levi, Luigino Dal Maso, Jolanta Lissowska, Carlo La Vecchia, Franco Merletti, Steve Schwartz, Oxana Shangina, Ariana Znaor, Gregory T. Wolf, Jonathan N. Hofmann, Ivana Holcatova, Wolfgang Ahrens, Rolando Herrero, Alexander W. Daudt, Kirsten B. Moysich, Heribert Ramroth, Karl T. Kelsey, Maria Paula Curado, Zuo-Feng Zhang, Ana M. B. Menezes, Philip Lazarus, Laura S. Rozek, Tongzhang Zheng, Paolo Boffetta, Jose P. Zevallos, Peter Thomson, Claire M. Healy, Stefania Boccia, Wilbert H.M. Peters, Stimson P. Schantz, Marta Vilensky, Joshua E. Muscat, Hermann Brenner, Sergio Koifman, Geoffrey Liu, Manoj B. Mahimkar, Leticia Fernandez, Winn, D.M., Lee, Y.-C., Hashibe, M., Boffetta, P., Agudo, A., Ahrens, W., Bencko, V., Benhamou, S., Boccia, S., Bosetti, C., Brennan, P., Brenner, H., Cadoni, G., Castellsague, X., Chen, C., Conway, D., Curado, M.P., D'Souza, G., Maso, L.D., Daudt, A.W., Ruyck, K.D., Diergaarde, B., Eluf-Neto, J., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Haddad, R.I., Hayes, R., Healy, C., Herrero, R., Hofmann, J., Holcátová, I., Hung, R., Kelsey, K., Kjaerheim, K., Koifman, S., Vecchia, C.L., Lacko, M., Lagiou, P., Lazarus, P., Levi, F., Li, G., Lissowska, J., Liu, G., Luce, D., Macfarlane, T., Mahimkar, M., Mates, D., Matsuo, K., McClean, M., Menezes, A., Menvielle, G., Merletti, F., Moysich, K., Muscat, J., Olshan, A., Pawlita, M., Peters, W.H.M., Ramroth, H., Rozek, L., Rudnai, P., Schantz, S., Schwartz, S., Serraino, D., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, Neonila and Thomson, P., Vaughan, T., Vilensky, M., Wolf, G., Wünsch-Filho, V., Yu, G., Zaridze, D., Zatonski, W., Zevallos, J.P., Zhang, Z.-F., Zheng, T.-Z., and Znaor, A.
Subjects: Larynx, Data Pooling, Oncology, medicine.medical_specialty, Research groups, Alcohol Drinking, Scientific productivity, Risk Factors, Internal medicine, Epidemiology, Humans, Medicine, Cooperative Behavior, Family history, Settore MED/42 - IGIENE GENERALE E APPLICATA, General Dentistry, business.industry, Smoking, Head and neck cancer, Confounding, medicine.disease, Diet, Surgery, medicine.anatomical_structure, Socioeconomic Factors, Otorhinolaryngology, Head and Neck Neoplasms, epidemiology, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, business
Abstract: The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects. © 2015 John Wiley & Sons A/S.
Published: 2015

19. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Author: Stefania Boccia, Wilbert H.M. Peters, Kristina Kjærheim, James McKay, Christopher I. Amos, David I. Conway, Dana Mates, Ana Maria Menezes, Antonio Agudo, Brenda Diergaarde, Rolando Herrero, Valerie Gaborieau, Martin Lacko, Cristina Canova, Neonila Szeszenia-Dąbrowska, Lorenzo Richiardi, Xiangjun Xiao, Victor Wünsch-Filho, Pagona Lagiou, David Zaridze, Maria Paula Curado, H. Bas Bueno-de-Mesquita, Mark C. Weissler, Rayjean J. Hung, Paolo Boffetta, Claire M. Healy, Marcos Brasilino de Carvalho, Fábio Daumas Nunes, Steve Thomas, Devasena Anantharaman, Paul Brennan, Mattias Johansson, Geoffrey Liu, Oxana Shangina, Ariana Znaor, Corina Lesseur, Eleonora Fabianova, Gabriella Cadoni, Andy R Ness, Eloiza H. Tajara, Gary J. Macfarlane, Jennifer R. Grandis, Annika Steffen, Jerry Polesel, Max Robinson, Marta Vilensky, Andrew F. Olshan, Wolfgang Ahrens, Silvia Franceschi, Amelie Chabrier, José Eluf-Neto, Jolanta Lissowska, Ivana Holcatova, Xavier Castellsagué, Nofer Institute of Occupational Medicine, Łódź, Poland, RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Keel Neus Oorheelkunde (9), Lesseur, C., Diergaarde, B., Olshan, A.F., Wünsch-Filho, V., Ness, A.R., Liu, G., Lacko, M., Eluf-Neto, J., Franceschi, S., Lagiou, P., Macfarlane, G.J., Richiardi, L., Boccia, S., Polesel, J., Kjaerheim, K., Zaridze, D., Johansson, M., Menezes, A.M., Curado, M.P., Robinson, M., Ahrens, W., Canova, C., Znaor, A., Castellsagué, X., Conway, D.I., Holcátová, I., Mates, D., Vilensky, M., Healy, C.M., Szeszenia-Dabrowska, N., Fabiánová, E., Lissowska, J., Grandis, J.R., Weissler, M.C., Tajara, E.H., Nunes, F.D., De Carvalho, M.B., Thomas, S., Hung, R.J., Peters, W.H.M., Herrero, R., Cadoni, G., Bueno-De-Mesquita, H.B., Steffen, A., Agudo, A., Shangina, O., Xiao, X., Gaborieau, V., Chabrier, A., Anantharaman, D., Boffetta, P., Amos, C.I., McKay, J.D., and Brennan, P.
Subjects: Male, 0301 basic medicine, Epidemiology, Genome-wide association study, Gastroenterology, Genome-wide association studies, INCIDÊNCIA, HLA Antigens, Genetics research, Aged, Case-Control Studies, Female, Genetic Markers, Genetic Variation, Haplotypes, Humans, Middle Aged, Mouth, Mouth Neoplasms, Papillomaviridae, Papillomavirus Infections, Pharyngeal Neoplasms, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetics, Oral cancer, genetic research, 3. Good health, Settore MED/31 - OTORINOLARINGOIATRIA, medicine.medical_specialty, Papillomaviruses, Genome-wide - oral cavity and pharyngeal cancer, Human leukocyte antigen, Biology, Article, 03 medical and health sciences, Internal medicine, medicine, Allele, Papil·lomavirus, Haplotype, Case-control study, Odds ratio, oral cancer, medicine.disease, Càncer de boca, 030104 developmental biology, Nasopharyngeal carcinoma, Immunology, Imputation (genetics)
Abstract: We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. Genotyping performed at the Center for Inherited Disease Research (CIDR) was funded through the U.S. National Institute of Dental and Craniofacial Research (NIDCR) grant 1X01HG007780-0. Genotyping for shared controls with the Lung OncoArray initiative was funded through the grant X01HG007492-0. Corina Lesseur undertook this work during the tenure of a Postdoctoral Fellowship awarded by the International Agency for Research on Cancer. The funders did not participate in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We acknowledge all of the participants involved in this research and the funders and support. We thank Dr. Leticia Fernandez (Instituto Nacional de Oncologia y Radiobiologia, La Habana, Cuba) for her contribution to the IARC ORC multicenter study. We are also grateful to Sergio Koifman (Escola Nacional de Saúde Pública, Rio de Janeiro, Brazil) for his contribution to the IARC Latin America multicenter study (Sergio Koifman passed away in May 2014) and to Xavier Castellsagué from the ARCAGE Barcelona Center who recently passed away (June 2016). The University of Pittsburgh head and neck cancer case-control study is supported by National Institutes of Health grants P50 CA097190 and P30 CA047904. The Carolina Head and Neck Cancer Study (CHANCE) was supported by the National Cancer Institute (R01-CA90731). The Head and Neck Genome Project (GENCAPO) was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (Grant numbers 04/12054-9 and 10/51168-0). The authors thank all the members of the GENCAPO team. The HN5000 study was funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0707-10034), the views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The Toronto study was funded by the Canadian Cancer Society Research Institute (020214) and the National Cancer Institute (U19 CA148127) and the Cancer Care Ontario Research Chair. The alcohol-related cancers and genetic susceptibility study in Europe (ARCAGE) was funded by the European Commission’s 5th Framework Program (QLK1-2001-00182), the Italian Association for Cancer Research, Compagnia di San Paolo/FIRMS, Region Piemonte, and Padova University (CPDA057222).The Rome Study was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC) IG 2011 10491 and IG2013 14220 to SB, and Fondazione Veronesi to SB. The IARC Latin American study was funded by the European Commission INCO-DC programme (IC18-CT97-0222), with additional funding from Fondo para la Investigacion Cientifica y Tecnologica (Argentina) and the Fundação de Amparo à Pesquisa do Estado de São Paulo (01/01768-2). The IARC Central Europe study was supported by European Commission’s INCO-COPERNICUS Program (IC15-CT98-0332), NIH/National Cancer Institute grant CA92039, and the World Cancer Research Foundation grant WCRF 99A28.The IARC Oral Cancer Multicenter study was funded by: grant S06 96 202489 05F02 from Europe against Cancer; Grants FIS 97/0024, FIS 97/0662, and BAE 01/5013 from Fondo de Investigaciones Sanitarias, Spain; UICC Yamagiwa-Yoshida Memorial International Cancer Study; National Cancer Institute of Canada; Italian Association for Research on Cancer; and the Pan American Health Organization. The coordination of EPIC study is financially supported
Published: 2016

20. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Author: Berthiller, Julien, Straif, Kurt, Agudo, Antonio, Ahrens, Wolfgang, Bezerra Dos Santos, Alexandre, Boccia, Stefania, Cadoni, Gabriella, Canova, Cristina, Castellsague, Xavier, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Fukuyama, Erica E, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, Lagiou, Pagona, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Macfarlane, Tatiana, Mates, Dana, McClean, Michael, Menezes, Ana, Merletti, Franco, Morgenstern, Hal, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark, Ramroth, Heribert, Rudnai, Peter, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Wei, Qingyi, Winn, Deborah M, Wünsch-Filho, Victor, Zhang, Zuo-Feng, Znaor, Ariana, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), and Berthiller, J. and Straif, K. and Agudo, A. and Ahrens, W. and Bezerra Dos Santos, A. and Boccia, S. and Cadoni, G. and Canova, C. and Castellsague, X. and Chen, C. and Conway, D. and Curado, M.P. and Dal Maso, L. and Daudt, A.W. and Fabianova, E. and Fernandez, L. and Franceschi, S. and Fukuyama, E.E. and Hayes, R.B. and Healy, C. and Herrero, R. and Holcatova, I. and Kelsey, K. and Kjaerheim, K. and Koifman, S. and Lagiou, P. and La Vecchia, C. and Lazarus, P. and Levi, F. and Lissowska, J. and Macfarlane, T. and Mates, D. and McClean, M. and Menezes, A. and Merletti, F. and Morgenstern, H. and Muscat, J. and Olshan, A.F. and Purdue, M. and Ramroth, H. and Rudnai, P. and Schwartz, S.M. and Serraino, D. and Shangina, O. and Smith, E. and Sturgis, E.M. and Szeszenia-Dabrowska, N. and Thomson, P. and Vaughan, T.L. and Vilensky, M. and Wei, Q. and Winn, D.M. and Wünsch-Filho, V. and Zhang, Z.-F. and Znaor, A. and Ferro, G. and Brennan, P. and Boffetta, P. and Hashibe, M. and Lee, Y.-C.A.
Subjects: Male, Gerontology, FATORES DE RISCO, Epidemiology, Head and neck cancer, low frequency cigarette smoking, pooled analysis, risk factors, Substance Misuse, 0302 clinical medicine, Risk Factors, Odds Ratio, Medicine, pooled analysi, Pooled data, European commission, 030212 general & internal medicine, Smoking and Cancer, Cancer, Head and Neck Neoplasm, Statistics, drinking behavior, General Medicine, Middle Aged, statistical model, Adult, Head and neck cancer low frequency cigarette smoking pooled analysis risk factors, 3. Good health, Pooled analysis, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Respiratory, Public Health and Health Services, Female, Christian ministry, Public Health, Settore MED/31 - OTORINOLARINGOIATRIA, Case-Control Studie, Adult, Logistic Model, Alcohol Drinking, European community, Library science, smoking, Cigarette Smoking, 03 medical and health sciences, Rare Diseases, Cigarette smoking, Clinical Research, Tobacco, Humans, human, Frame work, Dental/Oral and Craniofacial Disease, Settore MED/42 - IGIENE GENERALE E APPLICATA, Aged, head and neck tumor, Tobacco Smoke and Health, business.industry, Risk Factor, Prevention, case control study, Logistic Models, Good Health and Well Being, Multicenter study, Case-Control Studies, head and neck cancer, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: Funding • The pooled data coordination team (PBoffetta, MH, YCAL) were supported by National Cancer Institute grant R03CA113157 and by National Institute of Dental and Craniofacial Research grant R03DE016611 • The Milan study (CLV) was supported by the Italian Association for Research on Cancer (Grant no. 10068). • The Aviano study (LDM) was supported by a grant from the Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research • The Italy Multicenter study (DS) was supported by the Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research. • The Study from Switzerland (FL) was supported by the Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse [KFS-700, OCS-1633]. • The central Europe study (PBoffetta, PBrenan, EF, JL, DM, PR, OS, NS-D) was supported by the World Cancer Research Fund and the European Commission INCO-COPERNICUS Program [Contract No. IC15- CT98-0332] • The New York multicentre study (JM) was supported by a grant from National Institute of Health [P01CA068384 K07CA104231]. • The study from the Fred Hutchison Cancer Research Center from Seattle (CC, SMS) was supported by a National Institute of Health grant [R01CA048996, R01DE012609]. • The Iowa study (ES) was supported by National Institute of Health [NIDCR R01DE011979, NIDCR R01DE013110, FIRCA TW001500] and Veterans Affairs Merit Review Funds. • The North Carolina studies (AFO) were supported by National Institute of Health [R01CA061188], and in part by a grant from the National Institute of Environmental Health Sciences [P30ES010126]. • The Tampa study (PLazarus, JM) was supported by National Institute of Health grants [P01CA068384, K07CA104231, R01DE013158] • The Los Angeles study (Z-F Z, HM) was supported by grants from National Institute of Health [P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667] and the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center. • The Houston study (EMS, GL) was supported by a grant from National Institute of Health [R01ES011740, R01CA100264]. • The Puerto Rico study (RBH, MPP) was supported by a grant from National Institutes of Health (NCI) US and NIDCR intramural programs. • The Latin America study (PBoffetta, PBrenan, MV, LF, MPC, AM, AWD, SK, VW-F) was supported by Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a‘ Pesquisa no Estado de Sao Paulo (FAPESP) [No 01/01768-2], and European Commission [IC18-CT97-0222] • The IARC multicentre study (SF, RH, XC) was supported by Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [FIS 97/ 0024, FIS 97/0662, BAE 01/5013], International Union Against Cancer (UICC), and Yamagiwa-Yoshida Memorial International Cancer Study Grant. • The Boston study (KKelsey, MMcC) was supported by a grant from National Institute of Health [R01CA078609, R01CA100679]. • The Rome study (SB, GC) was supported by AIRC (Italian Agency for Research on Cancer). • The US multicentre study (BW) was supported by The Intramural Program of the National Cancer Institute, National Institute of Health, United States. • The Sao Paolo study (V W-F) was supported by Fundacao de Ampara a Pesquisa no Estado de Sao Paulo (FAPESP No 10/51168-0) • The MSKCC study (SS, G-P Y) was supported by a grant from National Institute of Health [R01CA051845]. • The Seattle-Leo stud (FV) was supported by a grant from National Institute of Health [R01CA030022] • The western Europe Study (PBoffetta, IH, WA, PLagiou, DS, LS, FM, CH, KKjaerheim, DC, TMc, PT, AA, AZ) was supported by European Community (5th Frame work Programme) grant no QLK1-CT-2001- 00182. • The Germany Heidelberg study (HR) was supported by the grant No. 01GB9702/3 from the German Ministry of Education and Research.
Published: 2016

21. Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author: Elena Matos, Renato Talamini, Karl T. Kelsey, Qingyi Wei, Shu Chun Chuang, Leticia Fernandez, Erich M. Sturgis, Joshua E. Muscat, Xavier Castellsagué, Alexander W. Daudt, Chu Chen, Paul Brennan, Andrew F. Olshan, Carlo La Vecchia, Fabio Levi, Rolando Herrero, Stephen M. Schwartz, Sergio Koifman, Eleonora Fabianova, Dana Mates, Stefania Boccia, Philip Lazarus, Neonilia Szeszenia-Dabrowska, Maria Paula Curado, Victor Wünsch-Filho, Luigino Dal Maso, Agnieszka Pilarska, Zuo-Feng Zhang, Deborah M. Winn, Gilles Ferro, Richard B. Hayes, Peter Rudnai, Paolo Boffetta, Oxana Shangina, Elaine M. Smith, Silvia Franceschi, Julien Berthiller, Mark P. Purdue, Ana Maria Menezes, Mia Hashibe, Juan Lence, Michael D. McClean, José Eluf-Neto, Hashibe, M., Brennan, P., Chuang, S.-C., Boccia, S., Castellsague, X., Chen, C., Curado, M.P., Maso, L.D., Daudt, A.W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Hayes, R.B., Herrero, R., Kelsey, K., Koifman, S., Vecchia, C.L., Lazarus, P., Levi, F., Lence, J.J., Mates, D., Matos, E., Menezes, A., McClean, M.D., Muscat, J., Eluf-Neto, J., Olshan, A.F., Purdue, M., Rudnai, P., Schwartz, S.M., Smith, E., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Wei, Q., Winn, D.M., Shangina, O., Pilarska, A., Zhang, Z.-F., Ferro, G., Berthiller, J., and Boffetta, P.
Subjects: education.field_of_study, medicine.medical_specialty, Adult, Aged, Alcohol Drinking, Alcohol Drinking/adverse effects, Alcohol Drinking/epidemiology, Case-Control Studies, Europe, Female, Head and Neck Neoplasms, Head and Neck Neoplasms/epidemiology, Head and Neck Neoplasms/etiology, Humans, Logistic Models, Male, Middle Aged, North America, North America/epidemiology, Risk Factors, Tobacco Use Disorder, Tobacco Use Disorder/complications, Tobacco Use Disorder/epidemiology, Epidemiology, business.industry, Population, Head and neck cancer, Case-control study, tobacco and alcohol use, Cancer, medicine.disease, Confidence interval, Surgery, Oncology, Internal medicine, medicine, head and neck cancer, Risk factor, Risk assessment, education, business
Abstract: Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden. Methods: We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (ψ) and population attributable risks (PAR). Results: A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (ψ = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases 60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America). Conclusions: Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases. (Cancer Epidemiol Biomarkers Prev 2009;18(2):541–50)
Published: 2009

22. Oral Health and Risk of Squamous Cell Carcinoma of the Head and Neck and Esophagus: Results of Two Multicentric Case-Control Studies

Author: Paul Brennan, Ana Maria Menezes, Maria Paula Curado, Paolo Boffetta, Victor Wünsch Filho, Leticia Fernandez, Elena Matos, Dana Mates, Jolanta Lissowska, Sergio Koifman, Neela Guha, José Eluf Neto, Neonila Szeszenia-Dabrowska, Oxana Shangina, Alexander W. Daudt, Rajesh Dikshit, David Zaridze, Guha, N., Boffetta, P., Wünsch Filho, V., Eluf Neto, J., Shangina, O., Zaridze, D., Curado, M.P., Koifman, S., Matos, E., Menezes, A., Szeszenia-Dabrowska, N., Fernandez, L., Mates, D., Daudt, A.W., Lissowska, J., Dikshit, R., and Brennan, P.
Subjects: Adult, Male, medicine.medical_specialty, Alcohol Drinking, Esophageal Neoplasms, Epidemiology, Oral Health, Oral health risk squamous cell carcinoma head neck esophagus results multicentric case-control studies, Oral hygiene, Risk Factors, Internal medicine, Oral and maxillofacial pathology, Tooth loss, Humans, Medicine, Europe, Eastern, Esophagus, Risk factor, Aged, business.industry, Smoking, Head and neck cancer, Odds ratio, Middle Aged, Oral Hygiene, medicine.disease, Surgery, Latin America, medicine.anatomical_structure, Socioeconomic Factors, Epidermoid carcinoma, Head and Neck Neoplasms, Case-Control Studies, Carcinoma, Squamous Cell, Female, medicine.symptom, business
Abstract: Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928 controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer (central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59). These results indicate that periodontal disease (as indicated by poor condition of the mouth and missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and esophagus. © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Published: 2007

23. Esophageal cancer in Central and Eastern Europe: Tobacco and alcohol

Author: Neonila Szeszenia-Dabrowska, Paul Brennan, David Zaridze, Paolo Boffetta, Oxana Shangina, Mia Hashibe, Vladimir Janout, Vladimir Bencko, Dana Mates, Hashibe, M., Boffetta, P., Janout, V., Zaridze, D., Shangina, O., Mates, D., Szeszenia-Dabrowska, N., Bencko, V., and Brennan, P.
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasm, Alcohol Drinking, Esophageal Neoplasms, Esophageal cancer, Population, Adenocarcinoma, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Europe, Eastern, Esophagus, Risk factor, education, Aged, education.field_of_study, Cocarcinogenesis, business.industry, Esophageal disease, Incidence, Smoking, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Oncology, Case-Control Studies, Carcinoma, Squamous Cell, Female, business
Abstract: Esophageal cancer mortality rates in Central and Eastern Europe have been increasing steadily and are expected to increase further in the future. To evaluate the role of risk factors for esophageal cancer in this population, a multicenter study was conducted, with investigation of tobacco and alcohol as one of the principal aims. We have included 192 squamous cell carcinoma (SCC) and 35 adenocarcinoma cases of the esophagus diagnosed at designated hospitals in 5 centers from Romania, Russia, the Czech Republic and Poland. Controls were frequency matched from patients in the same hospital as the cases (n = 1,114). Our results showed that the risk of esophageal SCC may be increased by approximately 7-fold for current smokers (OR = 7.41, 95% CI 3.98-13.79) and by 3-fold for ever alcohol drinkers (OR = 2.86, 95% CI 1.06-7.74). Dose-response relations were evident for both the frequency and duration of tobacco and of alcohol on the risk of esophageal SCC. Risk estimates for tobacco smoking were highest for lower esophageal SCCs, while risk estimates for alcohol drinking were highest for upper esophageal SCCs; though differences were not statistically significant. For adenocarcinoma of the esophagus, our results suggested a more modest increase in risk because of tobacco smoking than that for SCC of the esophagus and no association with alcohol consumption, although our sample size was small. A Synergist it interaction between tobacco and alcohol was observed for the risk of esophageal SCC, highlighting the importance of both factors for esophageal cancers in Central and Eastern Europe. © 2007 Wiley-Liss. Inc.
Published: 2007

24. Relation of allium vegetables intake with head and neck cancers: evidence from the INHANCE consortium

Author: Valentina Guercio, Dana Mates, Paul Brennan, Diego Serraino, Eleonora Fabianova, Fabio Levi, Carlo La Vecchia, Yuan Chin Amy Lee, Federica Turati, Mark P. Purdue, Hermann Brenner, Peter Rudnai, Oxana Shangina, Paolo Boffetta, Zuo-Feng Zhang, Cristina Bosetti, Alessandra Tavani, Carlotta Galeone, Jola Lissowska, Karl T. Kelsey, Michael D. McClean, Neonila Szeszenia-Dabrowska, Mia Hashibe, Claudio Pelucchi, Richard B. Hayes, Thomas L. Vaughan, Galeone, C., Turati, F., Zhang, Z.-F., Guercio, V., Tavani, A., Serraino, D., Brennan, P., Fabianova, E., Lissowska, J., Mates, D., Rudnai, P., Shangina, O., Szeszenia-Dabrowska, N., Vaughan, T.L., Kelsey, K., Mcclean, M., Levi, F., Hayes, R.B., Purdue, M.P., Bosetti, C., Brenner, H., Pelucchi, C., Lee, Y.-C.A., Hashibe, M., Boffetta, P., and La Vecchia, C.
Subjects: Oncology, medicine.medical_specialty, Article, Allium, Rare Diseases, Food Sciences, Risk Factors, Internal medicine, Epidemiology, Vegetables, medicine, Humans, Dental/Oral and Craniofacial Disease, Head and neck, Garlic, Cancer, Nutrition and Dietetics, biology, Nutrition & Dietetics, business.industry, Head and neck cancer, food and beverages, medicine.disease, biology.organism_classification, Surgery, Diet, Allium vegetables - head and neck cancers, Logistic Models, Head and Neck Neoplasms, Case-Control Studies, Allium vegetables, Public Health and Health Services, Onion, business, Biotechnology, Food Science
Abstract: Scope: Only a few studies analyzed the role of allium vegetables with reference to head and neck cancers (HNC), with mixed results. We investigated the potential favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Methods and results: We analyzed pooled individual-level data from eight case-control studies, including 4590 cases and 7082 controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC risk. Compared with no or low garlic use, the ORs of HNC were 0.95 (95% CI 0.71-1.27) for intermediate and 0.74 (95% CI 0.55-0.99) for high garlic use (p for trend = 0.02). The ORs of HNC for increasing categories of onion intake were 0.91 (95% CI 0.68-1.21) for >1 to =3 portions per week, and 0.83 (95% CI 0.60-1.13) for >3 portions per week (p for trend = 0.02), as compared to
Published: 2015

25. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Author: Gabriella Cadoni, Stefania Boccia, Alexander W. Daudt, Maria Paula Curado, Philip Lazarus, Kristina Kjærheim, Renato Talamini, Zuo-Feng Zhang, Wolfgang Ahrens, Thomas L. Vaughan, Marta Vilensky, Joshua E. Muscat, Mark P. Purdue, Qingyi Wei, OtÃ¡vio Alberto Curioni, Guo Pei Yu, Claire M. Healy, Keitaro Matsuo, Dana Mates, Yuan Chin Amy Lee, Rolando Herrero, Paolo Boffetta, JosÃ© Leopoldo Ferreira Antunes, Mia Hashibe, Elaine M. Smith, Lorenzo Richiardi, Oxana Shangina, Chu Chen, Antonio Agudo, Victor WÃ¼nsch Filho, Sergio Koifman, Pagona Lagiou, Deborah M. Winn, Michael D. McClean, Cristina Canova, Heribert Ramroth, Karl T. Kelsey, Peter Rudnai, Peter Thomson, Leticia Fernandez, P Brennan, Neonila Szeszenia-Dabrowska, Eleonora Fabianova, Hal Morgenstern, Stephen M. Schwartz, Xavier Castellsagué, Jolanta Lissowska, Andrew F. Olshan, Tatiana V. Macfarlane, Carlo La Vecchia, Ivana Holcatova, Ariana Znaor, Raquel Ajub Moyses, JosÃ© Eluf-Neto, David I. Conway, Tatiana Natasha Toporcov, Stimson P. Schantz, Richard B. Hayes, Fabio Levi, Erich M. Sturgis, Luigino Dal Maso, Ana M. B. Menezes, Silvia Franceschi, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Toporcov, T.N., Znaor, A., Zhang, Z.-F., Yu, G.-P., Winn, D.M., Wei, Q., Vilensky, M., Vaughan, T., Thomson, P., Talamini, R., Szeszenia-Dabrowska, N., Sturgis, E.M., Smith, E., Shangina, O., Schwartz, S.M., Schantz, S., Rudnai, P., Richiardi, L., Ramroth, H., Purdue, M.P., Olshan, A.F., Eluf-Neto, J., Muscat, J., Moyses, R.A., Morgenstern, H., Menezes, A., McClean, M., Matsuo, K., Mates, D., Macfarlane, T.V., Lissowska, J., Levi, F., Lazarus, P., Vecchia, C.L., Lagiou, P., Koifman, S., Kjaerheim, K., Kelsey, K., Holcatova, I., Herrero, R., Healy, C., Hayes, R.B., Franceschi, S., Fernandez, L., Fabianova, E., Daudt, A.W., Curioni, O.A., Maso, L.D., Curado, M.P., Conway, D.I., Chen, C., Castellsague, X., Canova, C., Cadoni, G., Brennan, P., Boccia, S., Antunes, J.L.F., Ahrens, W., Agudo, A., Boffetta, P., Hashibe, M., Lee, Y.-C.A., and Filho, V.W.
Subjects: Male, Aging, Epidemiology, head and neck cancer (HNC), Adult Age Factors Alcohol Drinking/*epidemiology Case-Control Studies Female Genetic Predisposition to Disease Head and Neck Neoplasms/*epidemiology/genetics Humans Incidence Male Middle Aged Odds Ratio Registries Risk Factors Sex Factors Smoking/*epidemiology Head and neck neoplasms alcohol drinking diet smoking, Risk Factors, Odds Ratio, Registries, Family history, Young adult, Cancer, Incidence (epidemiology), Incidence, Medicine (all), Statistics, Smoking, Age Factors, General Medicine, Middle Aged, 3. Good health, Public Health and Health Services, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Adult, medicine.medical_specialty, Alcohol Drinking, Head and neck neoplasms, smoking, Rare Diseases, Sex Factors, Clinical Research, Internal medicine, Tobacco, medicine, Humans, Genetic Predisposition to Disease, Dental/Oral and Craniofacial Disease, Tobacco Smoke and Health, business.industry, Prevention, Head and neck cancer, Alcohol drinking, Diet, Case-Control Studies, Head and Neck Neoplasms, Case-control study, prognostic factors, Odds ratio, medicine.disease, Confidence interval, Surgery, Good Health and Well Being, Attributable risk, head and neck cancer, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, diet, Digestive Diseases, business
Abstract: Toporcov, Tatiana Natasha Znaor, Ariana Zhang, Zuo-Feng Yu, Guo-Pei Winn, Deborah M Wei, Qingyi Vilensky, Marta Vaughan, Thomas Thomson, Peter Talamini, Renato Szeszenia-Dabrowska, Neonila Sturgis, Erich M Smith, Elaine Shangina, Oxana Schwartz, Stephen M Schantz, Stimson Rudnai, Peter Richiardi, Lorenzo Ramroth, Heribert Purdue, Mark P Olshan, Andrew F Eluf-Neto, Jose Muscat, Joshua Moyses, Raquel Ajub Morgenstern, Hal Menezes, Ana McClean, Michael Matsuo, Keitaro Mates, Dana Macfarlane, Tatiana V Lissowska, Jolanta Levi, Fabio Lazarus, Philip La Vecchia, Carlo Lagiou, Pagona Koifman, Sergio Kjaerheim, Kristina Kelsey, Karl Holcatova, Ivana Herrero, Rolando Healy, Claire Hayes, Richard B Franceschi, Silvia Fernandez, Leticia Fabianova, Eleonora Daudt, Alexander W Curioni, Otavio Alberto Maso, Luigino Dal Curado, Maria Paula Conway, David I Chen, Chu Castellsague, Xavier Canova, Cristina Cadoni, Gabriella Brennan, Paul Boccia, Stefania Antunes, Jose Leopoldo Ferreira Ahrens, Wolfgang Agudo, Antonio Boffetta, Paolo Hashibe, Mia Lee, Yuan-Chin Amy Filho, Victor Wunsch eng FIRCA TW01500/TW/FIC NIH HHS/ K07CA104231/CA/NCI NIH HHS/ P01CA068384/CA/NCI NIH HHS/ P30ES010126/ES/NIEHS NIH HHS/ P50CA90388/CA/NCI NIH HHS/ R01CA048996/CA/NCI NIH HHS/ R01CA100264/CA/NCI NIH HHS/ R01CA30022/CA/NCI NIH HHS/ R01CA51845/CA/NCI NIH HHS/ R01CA61188/CA/NCI NIH HHS/ R01DA11386/DA/NIDA NIH HHS/ R01DE012609/DE/NIDCR NIH HHS/ R01DE11979/DE/NIDCR NIH HHS/ R01DE13110/DE/NIDCR NIH HHS/ R01DE13158/DE/NIDCR NIH HHS/ R01ES11740/ES/NIEHS NIH HHS/ R03CA113157/CA/NCI NIH HHS/ R03CA77954/CA/NCI NIH HHS/ R03DE016611/DE/NIDCR NIH HHS/ R21ES011667/ES/NIEHS NIH HHS/ T32CA09142/CA/NCI NIH HHS/ U01CA96134/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2015/01/24 06:00 Int J Epidemiol. 2015 Feb;44(1):169-85. doi: 10.1093/ije/dyu255. Epub 2015 Jan 22.; International audience; BACKGROUND: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 case-control studies and conducted separate analyses for adults 45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults. CONCLUSIONS: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.
Published: 2015

26. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author: Conway, David I., Brenner, Darren R., McMahon, Alex D., Macpherson, Lorna M.D., Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A., Dal Maso, Luigino, Daudt, Alexander W., de Gois Filho, José F., D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B., Healy, Claire M., Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V., Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M., Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F., Purdue, Mark P., Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M., Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M., Szeszenia-Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L., Wei, Qingyi, Winn, Deborah M., Wunsch-Filho, Victor, Yu, Guo-Pei, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu-Chun, Ghodrat, Marianoosh, Amy Lee, Yuan-Chin, Hashibe, Mia, Brennan, Paul, International Prevention Research Institute (IPRI), Conway, D.I., Brenner, D.R., McMahon, A.D., Macpherson, L.M.D., Agudo, A., Ahrens, W., Bosetti, C., Brenner, H., Castellsague, X., Chen, C., Curado, M.P., Curioni, O.A., Maso, L.D., Daudt, A.W., De Gois Filho, J.F., D'Souza, G., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Hayes, R.B., Healy, C.M., Herrero, R., Holcatova, I., Jayaprakash, V., Kelsey, K., Kjaerheim, K., Koifman, S., La Vecchia, C., Lagiou, P., Lazarus, P., Levi, F., Lissowska, J., Luce, D., Macfarlane, T.V., Mates, D., Matos, E., McClean, M., Menezes, A.M., Menvielle, G., Merletti, F., Morgenstern, H., Moysich, K., Müller, H., Muscat, J., Olshan, A.F., Purdue, M.P., Ramroth, H., Richiardi, L., Rudnai, P., Schantz, S., Schwartz, S.M., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Thomson, P., Vaughan, T.L., Wei, Q., Winn, D.M., Wunsch-Filho, V., Yu, G.-P., Zhang, Z.-F., Zheng, T., Znaor, A., Boffetta, P., Chuang, S.-C., Ghodrat, M., Lee, Y.-C.A., Hashibe, M., and Brennan, P.
Subjects: Male, epidemiology, head and neck cancer, socioeconomic inequalities, Cancer Research, Alcohol Drinking/*adverse effects Case-Control Studies *Education Female Follow-Up Studies Global Health Head and Neck Neoplasms/*etiology Humans Income/*statistics & numerical data Male Meta-Analysis as Topic Middle Aged Prognosis Risk Factors Smoking/*adverse effects Socioeconomic Factors epidemiology head and neck cancer socioeconomic inequalities, Alcohol Drinking, Epidemiology, Head and neck cancer, Socioeconomic inequalities, Case-Control Studies, Female, Follow-Up Studies, Global Health, Head and Neck Neoplasms, Humans, Income, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Smoking, Socioeconomic Factors, Education, Oncology, Medicine (all), Article, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract: Conway, David I Brenner, Darren R McMahon, Alex D Macpherson, Lorna M D Agudo, Antonio Ahrens, Wolfgang Bosetti, Cristina Brenner, Hermann Castellsague, Xavier Chen, Chu Curado, Maria Paula Curioni, Otavio A Dal Maso, Luigino Daudt, Alexander W de Gois Filho, Jose F D'Souza, Gypsyamber Edefonti, Valeria Fabianova, Eleonora Fernandez, Leticia Franceschi, Silvia Gillison, Maura Hayes, Richard B Healy, Claire M Herrero, Rolando Holcatova, Ivana Jayaprakash, Vijayvel Kelsey, Karl Kjaerheim, Kristina Koifman, Sergio La Vecchia, Carlo Lagiou, Pagona Lazarus, Philip Levi, Fabio Lissowska, Jolanta Luce, Daniele Macfarlane, Tatiana V Mates, Dana Matos, Elena McClean, Michael Menezes, Ana M Menvielle, Gwenn Merletti, Franco Morgenstern, Hal Moysich, Kirsten Muller, Heiko Muscat, Joshua Olshan, Andrew F Purdue, Mark P Ramroth, Heribert Richiardi, Lorenzo Rudnai, Peter Schantz, Stimson Schwartz, Stephen M Shangina, Oxana Simonato, Lorenzo Smith, Elaine Stucker, Isabelle Sturgis, Erich M Szeszenia-Dabrowska, Neonila Talamini, Renato Thomson, Peter Vaughan, Thomas L Wei, Qingyi Winn, Deborah M Wunsch-Filho, Victor Yu, Guo-Pei Zhang, Zuo-Feng Zheng, Tongzhang Znaor, Ariana Boffetta, Paolo Chuang, Shu-Chun Ghodrat, Marianoosh Amy Lee, Yuan-Chin Hashibe, Mia Brennan, Paul eng DE016631/DE/NIDCR NIH HHS/ K07CA104231/CA/NCI NIH HHS/ NIDCR R01DE11979/DE/NIDCR NIH HHS/ NIDCRR01DE13110/DE/NIDCR NIH HHS/ NIH FIRCA TW01500/TW/FIC NIH HHS/ P01CA068384/CA/NCI NIH HHS/ P30ES010126/ES/NIEHS NIH HHS/ P50CA090388/CA/NCI NIH HHS/ R01 CA078609/CA/NCI NIH HHS/ R01 CA100679/CA/NCI NIH HHS/ R01CA030022/CA/NCI NIH HHS/ R01CA048996/CA/NCI NIH HHS/ R01CA051845/CA/NCI NIH HHS/ R01CA061188/CA/NCI NIH HHS/ R01CA078609/CA/NCI NIH HHS/ R01CA100264/CA/NCI NIH HHS/ R01CA100679/CA/NCI NIH HHS/ R01CA90731/CA/NCI NIH HHS/ R01DA011386/DA/NIDA NIH HHS/ R01DA026815/DA/NIDA NIH HHS/ R01DE012609/DE/NIDCR NIH HHS/ R01DE013158/DE/NIDCR NIH HHS/ R01ES011740/ES/NIEHS NIH HHS/ R03CA077954/CA/NCI NIH HHS/ R03CA113157/CA/NCI NIH HHS/ R03DE016611/DE/NIDCR NIH HHS/ R21ES011667/ES/NIEHS NIH HHS/ T32CA009142/CA/NCI NIH HHS/ U01CA096134/CA/NCI NIH HHS/ Intramural NIH HHS/ Comparative Study Multicenter Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2014/07/06 06:00 Int J Cancer. 2015 Mar 1;136(5):1125-39. doi: 10.1002/ijc.29063. Epub 2014 Aug 23.; International audience; Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.
Published: 2015

27. Evidence for an Important Role of Alcohol- and Aldehyde-Metabolizing Genes in Cancers of the Upper Aerodigestive Tract

Author: Neonila Szeszenia-Dabrowska, Vladimir Janout, Dana Mates, Amelie Chabrier, Norman Moullan, Rayjean J. Hung, David Zaridze, Mia Hashibe, Paul Brennan, Federico Canzian, Eleonora Fabianova, Vladimir Bencko, Paolo Boffetta, Oxana Shangina, Janet Hall, Hashibe, M., Boffetta, P., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Janout, V., Fabiánová, E., Bencko, V., Moullan, N., Chabrier, A., Hung, R., Hall, J., Canzian, F., and Brennan, P.
Subjects: Adult, Male, medicine.medical_specialty, Pathology, Genotype, Epidemiology, Population, Gastroenterology, Risk Factors, Internal medicine, Odds Ratio, Humans, Medicine, Europe, Eastern, Risk factor, education, Aged, ALDH2, education.field_of_study, business.industry, Aldehyde Dehydrogenase, Mitochondrial, Alcohol Dehydrogenase, Case-control study, Cancer, ADH1B, Odds ratio, Aldehyde Dehydrogenase, Middle Aged, Esophageal cancer, medicine.disease, Oncology, Head and Neck Neoplasms, Case-Control Studies, Female, Alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract, business
Abstract: Background: Incidence and mortality rates of upper aerodigestive tract cancers in Central Europe are among the highest in the world and have increased substantially in recent years. This increase is likely to be due to patterns of alcohol and tobacco consumption. Genetic susceptibility to upper aerodigestive tract cancer in relation to such exposures is an important aspect that should be investigated among populations in this region. Methods: A multicenter case-control study comprising 811 upper aerodigestive tract cancer cases and 1,083 controls was conducted in: Bucharest (Romania), Lodz (Poland), Moscow (Russia), Banska Bystrika (Slovakia), and Olomouc and Prague (Czech Republic). We analyzed six SNPs in three genes related to ethanol metabolism: alcohol dehydrogenase 1B and 1C (ADH1B, ADH1C) and aldehyde dehydrogenase 2 (ALDH2). Results: The ADH1B histidine allele at codon 48 was associated with a decreased risk of upper aerodigestive tract cancer; odds ratios (OR) were 0.36 [95% confidence interval (95% CI), 0.17-0.77] for medium/heavy drinkers and 0.57 (95% CI, 0.36-0.91) for never/light drinkers. Moderately increased risks were observed for the ADH1C 350Val allele (OR, 1.19; 95% CI, 0.98-1.55) and ADH1C 272Gln allele (OR, 1.24; 95% CI, 0.98-1.55). Medium/heavy drinkers who were heterozygous or homozygous at ALDH2 nucleotide position 248 were at a significantly increased risk of upper aerodigestive tract cancer (OR, 1.76; 95% CI, 1.13-2.75; OR, 5.79; 95% CI, 1.49-22.5, respectively), with a significant dose response for carrying variant alleles (P = 0.0007). Similar results were observed for the ALDH2 +82A>G and ALDH2 −261C>T polymorphisms. When results were analyzed by subsite, strong main effects were observed for squamous cell carcinoma of the esophagus for all six variants. Among the 30% of the population who were carriers of at least one ALDH2 variant, the attributable fraction among carriers (AFc) was 24.2% (5.7-38.3%) for all upper aerodigestive tract cancers, increasing to 58.7% (41.2-71.0%) for esophageal cancer. Among carriers who drank alcohol at least thrice to four times a week, the AFc for having at least one ALDH2 variant was 49% (21.3-66.8%) for all upper aerodigestive tract cancers, increasing to 68.9% (42.9-83.1%) for esophageal cancer. Conclusions: Polymorphisms in the ADH1B and ALDH2 genes are associated with upper aerodigestive tract cancer in Central European populations and interact substantially with alcohol consumption. (Cancer Epidemiol Biomarkers Prev 2006;15(4):696–703)
Published: 2006

28. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author: Chu Chen, Renato Talamini, Andrew F. Olshan, Dario Arzani, Tatiana V. Macfarlane, Claire M. Healy, Guo-Pei Yu, Hal Morgenstern, Jolanta Lissowska, Kristina Kjærheim, Leticia Fernandez, Walter Ricciardi, Yuan-Chin Lee, Rolando Herrero, Mark P. Purdue, Lorenzo Richiardi, Silvia Franceschi, Stefania Boccia, Emanuele Leoncini, Peter Thomson, Neonila Szeszenia-Dabrowska, Xavier Castellsagué, Thomas L. Vaughan, Alexander W. Daudt, Mia Hashibe, Isabelle Stücker, Sergio Koifman, David I. Conway, Jaroslav Betka, Pagona Lagiou, Antonio Agudo, Stephen M. Schwartz, Lorenzo Simonato, Shu Chun Chuang, Philip Lazarus, Wolfgang Ahrens, Livia Petrelli, Elena Matos, Zuo-Feng Zhang, Paul Brennan, Michael D. McClean, Stimson P. Schantz, Hermann Brenner, Peter Rudnai, Ana A. Menezes, Carlo La Vecchia, Dana Mates, Ariana Znaor, Joshua E. Muscat, Keitaro Matsuo, Luigino Dal Maso, Oxana Shangina, Richard B. Hayes, Paolo Boffetta, Eleonora Fabianova, Fabio Levi, Karl T. Kelsey, Gaetano Paludetti, Deborah M. Winn, Danièle Luce, Gabriella Cadoni, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., Brennan, P., Luce, D., Stucker, I., Matsuo, K., Talamini, R., La Vecchia, C., Olshan, A.F., Winn, D.M., Herrero, R., Franceschi, S., Castellsague, X., Muscat, J., Morgenstern, H., Zhang, Z.-F., Levi, F., Dal Maso, L., Kelsey, K., McClean, M., Vaughan, T.L., Lazarus, P., Purdue, M.P., Hayes, R.B., Chen, C., Schwartz, S.M., Shangina, O., Koifman, S., Ahrens, W., Matos, E., Lagiou, P., Lissowska, J., Szeszenia-Dabrowska, N., Fernandez, L., Menezes, A., Agudo, A., Daudt, A.W., Richiardi, L., Kjaerheim, K., Mates, D., Betka, J., Yu, G.-P., Schantz, S., Simonato, L., Brenner, H., Conway, D.I., Macfarlane, T.V., Thomson, P., Fabianova, E., Znaor, A., Rudnai, P., Healy, C., Boffetta, P., Chuang, S.-C., Lee, Y.-C.A., Hashibe, M., and Boccia, S.
Subjects: Adult, Male, Gerontology, Inverse Association, medicine.medical_specialty, Alcohol Drinking, Epidemiology, Overweight, Head and neck neoplasms, Article, Interviews as Topic, head and neck, Risk Factors, Odds Ratio, Humans, Medicine, Càncer, Settore MED/42 - IGIENE GENERALE E APPLICATA, Aged, Cancer, Height, business.industry, Incidence, Incidence (epidemiology), Smoking, Head and neck cancer, Case-control study, Odds ratio, Middle Aged, Alcohol Drinking/adverse effects, Alcohol Drinking/epidemiology, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms/diagnosis, Head and Neck Neoplasms/epidemiology, Logistic Models, Overweight/epidemiology, Smoking/adverse effects, Smoking/epidemiology, medicine.disease, Confidence interval, 3. Good health, health-care system, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, medicine.symptom, business, Consortium, Demography
Abstract: Leoncini, Emanuele Ricciardi, Walter Cadoni, Gabriella Arzani, Dario Petrelli, Livia Paludetti, Gaetano Brennan, Paul Luce, Daniele Stucker, Isabelle Matsuo, Keitaro Talamini, Renato La Vecchia, Carlo Olshan, Andrew F Winn, Deborah M Herrero, Rolando Franceschi, Silvia Castellsague, Xavier Muscat, Joshua Morgenstern, Hal Zhang, Zuo-Feng Levi, Fabio Dal Maso, Luigino Kelsey, Karl McClean, Michael Vaughan, Thomas L Lazarus, Philip Purdue, Mark P Hayes, Richard B Chen, Chu Schwartz, Stephen M Shangina, Oxana Koifman, Sergio Ahrens, Wolfgang Matos, Elena Lagiou, Pagona Lissowska, Jolanta Szeszenia-Dabrowska, Neonila Fernandez, Leticia Menezes, Ana Agudo, Antonio Daudt, Alexander W Richiardi, Lorenzo Kjaerheim, Kristina Mates, Dana Betka, Jaroslav Yu, Guo-Pei Schantz, Stimson Simonato, Lorenzo Brenner, Hermann Conway, David I Macfarlane, Tatiana V Thomson, Peter Fabianova, Eleonora Znaor, Ariana Rudnai, Peter Healy, Claire Boffetta, Paolo Chuang, Shu-Chun Lee, Yuan-Chin Amy Hashibe, Mia Boccia, Stefania eng Netherlands 2013/11/26 06:00 Eur J Epidemiol. 2014 Jan;29(1):35-48. doi: 10.1007/s10654-013-9863-2. Epub 2013 Nov 24.; International audience; Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.
Published: 2014

29. Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author: Andrew F. Olshan, Mark P. Purdue, Stimson P. Schantz, Victor Wünsch-Filho, Shu Chun Chuang, Guo Pei Yu, Marcos Brasilino de Carvalho, Elena Matos, Paul Brennan, Carlo La Vecchia, Ioan Nicolae Mates, Mia Hashibe, Annah Wyss, Hal Morgenstern, Deborah M. Winn, Peter Rudnai, Jolanta Lissowska, Yuan Chin Amy Lee, Eleonora Fabianova, Neonila Szeszenia-Dabrowska, Joshua E. Muscat, Silvia Franceschi, Stephen M. Schwartz, Pedro Michaluart, José Eluf-Neto, Xavier Castellsagué, Richard B. Hayes, Gabriella Cadoni, Luigino Dal Maso, Philip Lazarus, Stefania Boccia, Paolo Boffetta, Ana M. B. Menezes, Fabio Levi, Renato Talamini, Erich M. Sturgis, Qingyi Wei, Oxana Shangina, Alexander W. Daudt, Elaine M. Smith, Sergio Koifman, Chu Chen, Leticia Fernandez, Maria Paula Curado, Zuo-Feng Zhang, Rolando Herrero, Wyss, A., Hashibe, M., Chuang, S.-C., Lee, Y.-C.A., Zhang, Z.-F., Yu, G.-P., Winn, D.M., Wei, Q., Sturgis, E.M., Talamini, R., Dal Maso, L., Szeszenia-Dabrowska, N., Smith, E., Shangina, O., Schwartz, S.M., Chen, C., Schantz, S., Rudnai, P., Purdue, M.P., Eluf-Neto, J., Muscat, J., Morgenstern, H., Michaluart Jr., P., Menezes, A., Matos, E., Mates, I.N., Lissowska, J., Levi, F., Lazarus, P., La Vecchia, C., Koifman, S., Herrero, R., Hayes, R.B., Franceschi, S., Wünsch-Filho, V., Fernandez, L., Fabianova, E., Daudt, A.W., Curado, M.P., Boffetta, P., Castellsague, X., De Carvalho, M.B., Cadoni, G., Boccia, S., Brennan, P., Olshan, A.F., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)
Subjects: Adult, Male, medicine.medical_specialty, Cigar Smoking, Adolescent, Epidemiology, education, Logistic regression, smoking, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Age Distribution, head and neck neoplasms, Risk Factors, head and neck neoplasms, smoking, medicine, Odds Ratio, Humans, Young adult, Sex Distribution, Settore MED/42 - IGIENE GENERALE E APPLICATA, 030304 developmental biology, Aged, Aged, 80 and over, 0303 health sciences, Smoking pipe, education.field_of_study, 80 and over Female Head and Neck Neoplasms/*epidemiology Humans Male Middle Aged Odds Ratio Risk Factors Sex Distribution Smoking/*epidemiology Socioeconomic Factors Young Adult, business.industry, Head and neck cancer, Odds ratio, Middle Aged, medicine.disease, Adolescent Adult Age Distribution Aged Aged, Confidence interval, 3. Good health, Surgery, Socioeconomic Factors, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Systematic Reviews and Meta- and Pooled Analyses, Demography
Abstract: Wyss, Annah Hashibe, Mia Chuang, Shu-Chun Lee, Yuan-Chin Amy Zhang, Zuo-Feng Yu, Guo-Pei Winn, Deborah M Wei, Qingyi Talamini, Renato Szeszenia-Dabrowska, Neonila Sturgis, Erich M Smith, Elaine Shangina, Oxana Schwartz, Stephen M Schantz, Stimson Rudnai, Peter Purdue, Mark P Eluf-Neto, Jose Muscat, Joshua Morgenstern, Hal Michaluart, Pedro Jr Menezes, Ana Matos, Elena Mates, Ioan Nicolae Lissowska, Jolanta Levi, Fabio Lazarus, Philip La Vecchia, Carlo Koifman, Sergio Herrero, Rolando Hayes, Richard B Franceschi, Silvia Wunsch-Filho, Victor Fernandez, Leticia Fabianova, Eleonora Daudt, Alexander W Dal Maso, Luigino Curado, Maria Paula Chen, Chu Castellsague, Xavier de Carvalho, Marcos Brasilino Cadoni, Gabriella Boccia, Stefania Brennan, Paul Boffetta, Paolo Olshan, Andrew F eng R03 CA113157/CA/NCI NIH HHS/ R24 HD041025/HD/NICHD NIH HHS/ T32-CA09330/CA/NCI NIH HHS/ T32ES007018/ES/NIEHS NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural 2013/07/03 06:00 Am J Epidemiol. 2013 Sep 1;178(5):679-90. doi: 10.1093/aje/kwt029. Epub 2013 Jun 30.; International audience; Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend
Published: 2013

30. An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies

Author: Paul Brennan, Jay H. Lubin, Elaine M. Smith, Dana Mates, Eleonora Fabianova, Neonilia Szeszenia-Dabrowska, Alexander W. Daudt, Mia M. Gaudet, Rolando Herrero, Victor Wünsch-Filho, Mark P. Purdue, Philip Lazarus, Hal Morgenstern, Silvia Franceschi, Peter Rudnai, Jolanta Lissowska, Xavier Castellsagué, Paolo Boffetta, Luigino Dal Maso, Karl T. Kelsey, Elena Matos, Erich M. Sturgis, Fabio Levi, Oxana Shangina, Joshua E. Muscat, Ana M. B. Menezes, José Eluf Neto, Stephen M. Schwartz, Maria Paula Curado, Zuo-Feng Zhang, Deborah M. Winn, Andrew F. Olshan, Carlo La Vecchia, Thangarajan Rajkumar, Richard B. Hayes, Sergio Koifman, Renato Talamini, Qingyi Wei, Leticia Fernandez, Mia Hashibe, Michael D. McClean, Chu Chen, Lubin, J.H., Muscat, J., Gaudet, M.M., Olshan, A.F., Curado, M.P., Dal Maso, L., Wünsch-Filho, V., Sturgis, E.M., Szeszenia-Dabrowska, N., Castellsague, X., Zhang, Z.-F., Smith, E., Fernandez, L., Matos, E., Franceschi, S., Fabianova, E., Rudnai, P., Purdue, M.P., Mates, D., Wei, Q., Herrero, R., Kelsey, K., Morgenstern, H., Shangina, O., Koifman, S., Lissowska, J., Levi, F., Daudt, A.W., Neto, J.E., Chen, C., Lazarus, P., Winn, D.M., Schwartz, S.M., Boffetta, P., Brennan, P., Menezes, A., Vecchia, C.L., McClean, M., Talamini, R., Rajkumar, T., Hayes, R.B., and Hashibe, M.
Subjects: ratio, Larynx, Male, pharynx, Cancer Research, medicine.medical_specialty, Alcohol Drinking, cigarette smoking, Dentistry, Article, Body Mass Index, BMI, oral, Sex Factors, Risk Factors, Internal medicine, Epidemiology, Odds Ratio, cancer, Medicine, Humans, Mass index, Laryngeal Neoplasms, larynx, Hypopharyngeal Neoplasms, odd, alcohol, business.industry, Pharynx, Smoking, Case-control study, Odds ratio, Oropharyngeal Neoplasms, medicine.anatomical_structure, Oncology, Case-Control Studies, Female, Mouth Neoplasms, business, Alcohol consumption, Body mass index, case-control
Abstract: Background: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. Methods: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. Results: ORs were increased in underweight (
Published: 2011

31. Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions

Author: Karina Braga Ribeiro, Maria Paula Curado, José Eluf-Neto, Tim Waterboer, José Eduardo Levi, Paul Brennan, David Zaridze, Eleonora Fabianova, Alexander W. Daudt, Leticia Fernandez, Paolo Boffetta, Neonila Szeszenia-Dabrowska, Ana M. B. Menezes, Tarik Gheit, Elena Matos, Vladimir Bencko, Victor Wünsch-Filho, Dana Mates, Oxana Shangina, Sergio Koifman, Michael Pawlita, Massimo Tommasino, Jolanta Lissowska, Ribeiro, K.B., Levi, J.E., Pawlita, M., Koifman, S., Matos, E., Eluf-Neto, J., Wunsch-Filho, V., Curado, M.P., Shangina, O., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Daudt, A., Menezes, A., Bencko, V., Mates, D., Fernandez, L., Fabianova, E., Gheit, T., Tommasino, M., Boffetta, P., Brennan, P., and Waterboer, T.
Subjects: Oncology, Adult, Male, medicine.medical_specialty, Epidemiology, ESTUDOS DE CASOS E CONTROLES, prevalence, Antibodies, Viral, Serology, Internal medicine, medicine, Carcinoma, cancer, Humans, DNA Probes, HPV, Laryngeal Neoplasms, Aged, Aged, 80 and over, Human papillomavirus 16, business.industry, Head and neck cancer, Papillomavirus Infections, HPV infection, Cancer, papillomaviru, Pharyngeal Neoplasms, General Medicine, head, Middle Aged, medicine.disease, Head and neck squamous-cell carcinoma, neck, Koilocyte, Europe, Hypopharynx, Oropharyngeal Neoplasms, Latin America, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, Sample collection, business
Abstract: Background: Recent studies support an important role for human papillomavirus (HPV) in a subgroup of head and neck squamous cell carcinomas (HNSCC). We have evaluated the HPV deoxyribonucleic acid (DNA) prevalence as well as the association between serological response to HPV infection and HNSCC in two distinct populations from Central Europe (CE) and Latin America (LA). Methods: Cases (n=2214) and controls (n=3319) were recruited from 1998 to 2003, using a similar protocol including questionnaire and blood sample collection. Tumour DNA from 196 fresh tissue biopsies was analysed for multiple HPV types followed by an HPV type-specific polymerase chain reaction (PCR) protocol towards the E7 gene from HPV 16. Using multiplex serology, serum samples were analysed for antibodies to 17 HPV types. Statistical analysis included the estimation of adjusted odds ratios (ORs) and the respective 95% confidence intervals (CIs). Results: HPV16 E7 DNA prevalence among cases was 3.1% (6/196), including 4.4% in the oropharynx (3/68), 3.8% in the hypopharynx/larynx (3/78) and 0% among 50 cases of oral cavity carcinomas. Positivity for both HPV16 E6 and E7 antibodies was associated with a very high risk of oropharyngeal cancer (OR=179, 95% CI 35.8-899) and hypopharyngeal/laryngeal cancer (OR=14.9, 95% CI 2.92-76.1).Conclusions: A very low prevalence of HPV DNA and serum antibodies was observed among cases in both CE and LA. The proportion of head and neck cancer caused by HPV may vary substantially between different geographical regions and studies that are designed to evaluate the impact of HPV vaccination on HNSCC need to consider this heterogeneity. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2010; all rights reserved.
Published: 2011

32. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Author: Jorge R. Toro, Vladimir Janout, Zhaoming Wang, Françoise Clavel-Chapelon, Petra H.M. Peeters, Paul Brennan, Camilla Stoltenberg, Hélène Blanché, Diana Zelenika, Vsevolod Matveev, Naomi E. Allen, Rosario Tumino, Vladimir Bencko, H. Bas Bueno-de-Mesquita, Lee E. Moore, María José Sánchez, Mark P. Purdue, Stephen J. Chanock, Kim Overvad, Kvetoslava Koppova, Joanne S. Colt, Eleonora Fabianova, Yuanqing Ye, Grethe S. Tell, Simon Heath, José Ramón Quirós, Egbert Oosterwijk, Amy Hutchinson, Jan Lubinski, Kristian Hveem, Peter Rudnai, Alexandru Bucur, Elio Riboli, James McKay, Ivo Gut, Paolo Vineis, Rosamonde E. Banks, Douglas F. Easton, Jarmo Virtamo, Wong-Ho Chow, Neonila Szeszenia-Dabrowska, Isabelle Romieu, Mark Lathrop, Demetrius Albanes, Kevin B. Jacobs, Sita H. Vermeulen, Egor Prokhortchouk, Carmen Navarro, Ann W. Hsing, Doris Lechner, M. Dorronsoro, Kendra Schwartz, Konstantin G. Skryabin, Mattias Johansson, Eric J. Duell, Valerie Gaborieau, W. Ryan Diver, Susan M. Gapstur, Börje Ljungberg, Dimitrios Trichopoulos, Paul D.P. Pharoah, Gilles Thomas, Victoria L. Stevens, Paolo Boffetta, Vittorio Krogh, David Zaridze, Lambertus A. Kiemeney, Joseph F. Fraumeni, Eugenia S. Boulygina, Kay-Tee Khaw, Olivier Cussenot, Heiner Boeing, Nathaniel Rothman, Michael J. Thun, Saskia S. L. van der Marel, Anush Mukeria, Alexander M. Mazur, Salvatore Panico, Peter Selby, Ghislaine Scelo, Faith G. Davis, Simone Benhamou, Joanna Trubicka, Christine D. Berg, Anne Tjønneland, Eva Ardanaz, Jolanta Lissowska, Katja K.H. Aben, Xifeng Wu, Rajesh Kumar, Jakob Linseisen, Nikolai N. Chekanov, Domenico Palli, Stephanie J. Weinstein, Inger Njølstad, Mario Foglio, Lars J. Vatten, Meredith Yeager, Xia Pu, Robert L. Grubb, Oxana Shangina, Christopher G. Wood, Patricia Harnden, Lenka Foretova, Purdue, M.P., Johansson, M., Zelenika, D., Toro, J.R., Scelo, G., Moore, L.E., Prokhortchouk, E., Wu, X., Kiemeney, L.A., Gaborieau, V., Jacobs, K.B., Chow, W.-H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J.S., Davis, F.G., Schwartz, K.L., Banks, R.E., Selby, P.J., Harnden, P., Berg, C.D., Hsing, A.W., Grubb, R.L., Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E.J., Quiós, J.R., Sanchez, M.-J., Navarro, C., Ardanaz, E., Dorronsoro, M., Khaw, K.-T., Allen, N.E., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Trichopoulos, D., Linseisen, J., Ljungberg, B., Overvad, K., Tjønneland, A., Romieu, I., Riboli, E., Mukeria, A., Shangina, O., Stevens, V.L., Thun, M.J., Diver, W.R., Gapstur, S.M., Pharoah, P.D., Easton, D.F., Albanes, D., Weinstein, S.J., Virtamo, J., Vatten, L., Hveem, K., Njølstad, I., Tell, G.S., Stoltenberg, C., Kumar, R., Koppova, K., Cussenot, O., Benhamou, S., Oosterwijk, E., Vermeulen, S.H., Aben, K.K.H., Van Der Marel, S.L., Ye, Y., Wood, C.G., Pu, X., Mazur, A.M., Boulygina, E.S., Chekanov, N.N., Foglio, M., Lechner, D., Gut, I., Heath, S., Blanche, H., Hutchinson, A., Thomas, G., Wang, Z., Yeager, M., Fraumeni Jr., J.F., Skryabin, K.G., McKay, J.D., Rothman, N., Chanock, S.J., Lathrop, M., and Brennan, P.
Subjects: Genetics and epigenetic pathways of disease [NCMLS 6], Single-nucleotide polymorphism, Locus (genetics), Genome-wide association study, Biology, carcinoma, association study, Genome, Polymorphism, Single Nucleotide, susceptibility, Article, Càncer de ronyó, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], 03 medical and health sciences, 0302 clinical medicine, Gene mapping, Risk Factors, Genetics, Humans, Genetic Predisposition to Disease, Genome-wide, Gene, Carcinoma, Renal Cell, 030304 developmental biology, 11q13.3, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], 0303 health sciences, Genome, Human, Chromosomes, Human, Pair 11, Kidney cancer, Genomics, 2p21, SCARB1, Kidney Neoplasms, 3. Good health, Genòmica, 030220 oncology & carcinogenesis, Case-Control Studies, Chromosomes, Human, Pair 2, loci, Human genome, renal, Genome-Wide Association Study
Abstract: Contains fulltext : 97937.pdf (Publisher’s version ) (Closed access) We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10) and rs7579899 (P = 2.3 x 10), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(1)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
Published: 2011

33. Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-Control Data

Author: Renato Talamini, Karl T. Kelsey, Qingyi Wei, Oxana Shangina, Paul Brennan, Mia Hashibe, Elena Matos, Philip Lazarus, Alexander W. Daudt, Leticia Fernandez, Carlo La Vecchia, Rolando Herrero, Eleonora Fabianova, Andrew F. Olshan, Deborah M. Winn, Mia M. Gaudet, Neonilia Szeszenia-Dabrowska, Paolo Boffetta, Erich M. Sturgis, Mark P. Purdue, Xavier Castellsagué, Joshua E. Muscat, Maria Paula Curado, Zuo-Feng Zhang, Sergio Koifman, Richard B. Hayes, Michael D. McClean, José Eluf Neto, Peter Rudnai, Ioan Nicolae Mates, Stephen M. Schwartz, Victor Wünsch-Filho, Silvia Franceschi, Luigino Dal Maso, Chu Chen, Ana M. B. Menezes, Jay H. Lubin, Fabio Levi, Hal Morgenstern, Jolanta Lissowska, Lubin, J.H., Gaudet, M.M., Olshan, A.F., Kelsey, K., Boffetta, P., Brennan, P., Castellsague, X., Chen, C., Curado, M.P., Maso, L.D., Daudt, A.W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., Levi, F., Lissowska, J., Mates, I.N., Matos, E., McClean, M., Menezes, A., Morgenstern, H., Muscat, J., Neto, J.E., Purdue, M.P., Rudnai, P., Schwartz, S.M., Shangina, O., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Wei, Q., Winn, D., Zhang, Z.-F., Hashibe, M., and Hayes, R.B.
Subjects: Larynx, pharynx, medicine.medical_specialty, Alcohol Drinking, Epidemiology, Dentistry, cigarette, Gastroenterology, Body Mass Index, odds ratios, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Mass index, NEOPLASIAS DE CABEÇA E PESCOÇO, Laryngeal Neoplasms, larynx, business.industry, Smoking, Head and neck cancer, Pharynx, smoking: alcohol: cancer, Cancer, Pharyngeal Neoplasms, Odds ratio, medicine.disease, medicine.anatomical_structure, Case-Control Studies, oral cavity, Mouth Neoplasms, business, Systematic Reviews and Meta- and Pooled Analyses, Body mass index
Abstract: Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.
Published: 2010
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34. Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies

Author: Karl T. Kelsey, Luigino Dal Maso, Jolanta Lissowska, Mark P. Purdue, Maria Paula Curado, Zuo-Feng Zhang, Debbie Winn, Joshua E. Muscat, Richard B. Hayes, Fabio Levi, S.M. Schwartz, Elaine Smith, Xavier Castellsagué, Mia Hashibe, V. Wünsch-Filho, Erich M. Sturgis, José Eluf Neto, Hal Morgenstern, Qingyi Wei, Alexander W. Daudt, Sergio Koifman, Eleonora Fabianova, Peter Rudnai, Leticia Fernandez, Rolando Herrero, Oxana Shangina, Philip Lazarus, Ioan Nicolae Mates, Chu Chen, Paolo Boffetta, Elena Matos, P Brennan, Silvia Franceschi, Ana M. B. Menezes, Jay H. Lubin, R. Talamini, Neonilia Szeszenia-Dabrowska, Carlo La Vecchia, Lubin, J.H., Purdue, M., Kelsey, K., Zhang, Z.-F., Winn, D., Wei, Q., Talamini, R., Szeszenia-Dabrowska, N., Sturgis, E.M., Smith, E., Shangina, O., Schwartz, S.M., Rudnai, P., Neto, J.E., Muscat, J., Morgenstern, H., Menezes, A., Matos, E., Mates, I.N., Lissowska, J., Levi, F., Lazarus, P., Vecchia, C.L., Koifman, S., Herrero, R., Franceschi, S., Wünsch-Filho, V., Fernandez, L., Fabianova, E., Daudt, A.W., Maso, L.D., Curado, M.P., Chen, C., Castellsague, X., Brennan, P., Boffetta, P., Hashibe, M., and Hayes, R.B.
Subjects: medicine.medical_specialty, Alcohol Drinking, Epidemiology, Risk Factors, Internal medicine, medicine, Odds Ratio, Humans, Risk factor, Laryngeal Neoplasms, Mouth neoplasm, business.industry, Head and neck cancer, Pharynx, Smoking, Case-control study, Cancer, Pharyngeal Neoplasms, Odds ratio, medicine.disease, Surgery, medicine.anatomical_structure, Head and Neck Neoplasms, Case-Control Studies, Mouth Neoplasms, Total exposure rate effects alcohol smoking risk head neck cancer pooled analysis case-control studies, business
Abstract: Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years) and its modification by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls. Above 15 cigarettes/day, the EOR/pack-year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration. Estimates of EOR/pack-year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack-years. EOR/drink-year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited. EOR/drink-year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink-years and not drinks/day.
Published: 2009

35. Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Author: Renato Talamini, Julien Berthiller, Qingyi Wei, Xavier Castellsagué, Elena Matos, Carlo La Vecchia, Maria Paula Curado, Silvia Franceschi, Paul Brennan, Zuo-Feng Zhang, Mia Hashibe, Luigino Dal Maso, Juan Lence, Dana Mates, Leticia Fernandez, Alexander W. Daudt, David Zaridze, Richard B. Hayes, Eleonora Fabianova, Ana M. B. Menezes, Neonilia Szeszenia-Dabrowska, Gilles Ferro, Peter Rudnai, Joshua E. Muscat, Fabio Levi, Rolando Herrero, José Eluf-Neto, Victor Wünsch-Filho, Jolanta Lissowska, Oxana Shangina, Eva Negri, Erich M. Sturgis, Philip Lazarus, Andrew F. Olshan, Paolo Boffetta, Deborah M. Winn, Sergio Koifman, Negri, E., Boffetta, P., Berthiller, J., Castellsague, X., Curado, M.P., Maso, L.D., Daudt, A.W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Hayes, R.B., Herrero, R., Koifman, S., Lazarus, P., Lence, J.J., Levi, F., Mates, D., Matos, E., Menezes, A., Muscat, J., Eluf-Neto, J., Olshan, A.F., Rudnai, P., Shangina, O., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Wei, Q., Winn, D.M., Zaridze, D., Lissowska, J., Zhang, Z.-F., Ferro, G., Brennan, P., Vecchia, C.L., and Hashibe, M.
Subjects: Adult, Male, Risk, Cancer Research, medicine.medical_specialty, Adolescent, Models, Biological, Article, Aged, Aged, 80 and over, Case-Control Studies, Family Health, Female, Head and Neck Neoplasms, Head and Neck Neoplasms/diagnosis, Head and Neck Neoplasms/epidemiology, Head and Neck Neoplasms/genetics, Humans, Middle Aged, Odds Ratio, Tobacco, Internal medicine, Epidemiology, Genetic predisposition, medicine, history of cancer, Family history, business.industry, Head and neck cancer, Confounding, Case-control study, Cancer, Odds ratio, medicine.disease, Surgery, Oncology, business
Abstract: Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC OR = 1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR = 2.2, 95% CI 1.6-3.1) rather than a parent (OR = 1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR = 1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR = 1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR = 1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC. © 2008 Wiley-Liss, Inc.
Published: 2009

36. Multiple ADH genes are associated with upper aerodigestive cancers

Author: José Eluf-Neto, Mia Hashibe, Juan Lence, Renato Talamini, Luigi Barzan, Jolanta Lissowska, David Zaridze, Ioan Nicolae Mates, José Carlos de Oliveira, Gary J Macfarlane, Dana Mates, Simone Benhamou, Ivana Holcatova, Neonilia Szeszenia-Dabrowska, Ana M. B. Menezes, Lorenzo Richiardi, Tatiana V. Macfarlane, Helena Kollárová, Areti Lagiou, Amelie Chabrier, Christine Bouchardy, Pagona Lagiou, Xavier Castellsagué, Kristina Kjærheim, Oxana Shangina, Valerie Gaborieau, James McKay, Vladimir Bencko, Antonio Agudo, Marinel Mór Dall'Agnol, Elena Matos, Rosalina Jorge Koifman, Franco Merletti, Cristina Canova, Ariana Znaor, Paul Brennan, Ray Lowry, Eleonora Fabianova, José Eduardo Levi, Paolo Boffetta, Rayjean J. Hung, Patricia A. McKinney, L Simonato, Sergio Koifman, Vladimir Janout, Maria Paula Curado, Victor Wünsch-Filho, Leticia Fernandez, David I. Conway, Hashibe, M., McKay, J.D., Curado, M.P., Oliveira, J.C., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V., Eluf-Neto, J., Levi, J.E., Matos, E., Lagiou, P., Lagiou, A., Benhamou, S., Bouchardy, C., Szeszenia-Dabrowska, N., Menezes, A., Dall'Agnol, M.M., Merletti, F., Richiardi, L., Fernandez, L., Lence, J., Talamini, R., Barzan, L., Mates, D., Mates, I.N., Kjaerheim, K., MacFarlane, G.J., MacFarlane, T.V., Simonato, L., Canova, C., Holcátová, I., Agudo, A., Castellsagué, X., Lowry, R., Janout, V., Kollarova, H., Conway, D.I., McKinney, P.A., Znaor, A., Fabianova, E., Bencko, V., Lissowska, J., Chabrier, A., Hung, R.J., Gaborieau, V., Boffetta, P., and Brennan, P.
Subjects: Adult, Male, Esophageal Neoplasms, Alcohol Drinking, Genotype, Alcohol Dehydrogenase/genetics, Models, Biological, Polymorphism, Single Nucleotide, Age Distribution, Risk Factors, Multiple ADH genes associated upper aerodigestive cancers, Genetics, medicine, Humans, chemoprevention, Genetic Predisposition to Disease, Risk factor, Laryngeal Neoplasms, Gene, Alcohol dehydrogenase, ddc:613, biology, Alcohol-Induced Disorders/epidemiology/genetics, Alcohol Dehydrogenase, Esophageal Neoplasms/epidemiology/genetics, ADH1B, Cancer, Genetic markers, Middle Aged, medicine.disease, Laryngeal Neoplasms/epidemiology/genetics, Alcohol-Induced Disorders, Oropharyngeal Neoplasms/epidemiology/genetics, Oropharyngeal Neoplasms, Genetic marker, ADH7, Case-Control Studies, Cancer research, biology.protein, Female, Cancer Etiology
Abstract: Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10-10 and 10 -9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology. © 2008 Nature Publishing Group.
Published: 2008

37. Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe

Author: Paul Brennan, Charles C. Hsu, Eleonora Fabianova, David Zaridze, Amir Sapkota, Dana Mates, Neonilia Szeszenia-Dabrowska, Paolo Boffetta, Peter Rudnai, Ivana Holcatova, Vladimir Janout, Mia Hashibe, Oxana Shangina, Sapkota, A., Hsu, C.C., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Fabiánová, E., Rudnai, P., Janout, V., Holcatova, I., Brennan, P., Boffetta, P., and Hashibe, M.
Subjects: Male, squamous cell carcinoma, Cancer Research, Esophageal Neoplasms, Gastroenterology, Food group, Risk Factors, Surveys and Questionnaires, Odds Ratio, Multicenter Studies as Topic, Europe, Eastern, Czech Republic, Incidence (epidemiology), Smoking, Middle Aged, Esophageal cancer, Eastern european, medicine.anatomical_structure, Oncology, risk factor, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, Adult, Slovakia, medicine.medical_specialty, Alcohol Drinking, Dietary, Age Distribution, Internal medicine, upper aerodigestive tract, Confidence Intervals, medicine, Humans, Esophagus, Laryngeal Neoplasms, Life Style, Aged, Demography, Hungary, Romania, business.industry, Pharynx, Cancer, Pharyngeal Neoplasms, Odds ratio, medicine.disease, Diet, Logistic Models, Case-Control Studies, business
Abstract: Objective: The incidence of squamous cell carcinoma of upper aerodigestive tract (UADT: oral cavity, pharynx, larynx, and esophagus) has been increasing in central and eastern European countries. We investigated the relationship between diet and UADT cancers in these high risk areas. Methods: We used data from hospital-based case-control study of 948 UADT cancer cases and 1,228 controls conducted in Romania, Hungary, Poland, Russia, Slovakia, and Czech Republic. Standardized questionnaire were used to collect information on 23 different food items, along with alcohol and tobacco consumptions. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the UADT cancers after adjusting for center, age, sex, tobacco & alcohol intake, and other food groups. Results: Consumption of dairy product was negatively associated with selected UADT cancers: larynx (OR: 0.38, CI: 0.23-0.62) and esophagus (OR: 0.55, CI: 0.33-0.93). While consumption of yellow/orange vegetables were inversely associated with oral/pharyngeal and laryngeal cancer (OR: 0.53, CI: 0.35-0.81 and OR: 0.62, CI: 0.38-1.00, respectively), preserved vegetable was positively associated with oral/pharyngeal and laryngeal cancer risk (ptrend < 0.01 for both). Conclusion: Specific dietary components may play a role in the development of UADT cancers in the high-risk region of central and eastern Europe. © 2008 Springer Science+Business Media B.V.
Published: 2008

38. The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract

Author: David Zaridze, Oxana Shangina, Mia Hashibe, Paul Brennan, James McKay, Eleonora Fabianova, Vladimir Janout, Dana Mates, Janet Hall, Rayjean J. Hung, Amelie Chabrier, Federico Canzian, Neonila Szeszenia-Dabrowska, Paolo Boffetta, Norman Moullan, Valerie Gaborieau, Ivana Holcatova, Hall, J., Hashibe, M., Boffetta, P., Gaborieau, V., Moullan, N., Chabrier, A., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Janout, V., Fabiánová, E., Holcatova, I., Hung, R.J., McKay, J., Canzian, F., and Brennan, P.
Subjects: Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Alcohol Drinking, DNA Repair, Esophageal Neoplasms, DNA repair, Single-nucleotide polymorphism, Biology, Risk Factors, Internal medicine, medicine, Humans, CHEK2, Laryngeal Neoplasms, Aged, Genetics, Mouth neoplasm, Cell Cycle, Smoking, O-6-methylguanine-DNA methyltransferase, Cancer, Genetic Variation, Pharyngeal Neoplasms, General Medicine, Odds ratio, Cell cycle, Middle Aged, medicine.disease, Europe, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, association sequence variants DNA repair and cell cycle genes cancers upper aerodigestive tract
Abstract: Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and alcohol can directly or indirectly generate DNA damage, which if unrepaired can give rise to mutations, unregulated cell growth and apoptosis induction. To clarify the role of DNA repair and cell cycle control proteins in UADT cancer susceptibility, we studied the risk in relation to 28 SNPs in 18 DNA repair enzymes and 9 SNPs in 7 cell cycle control genes. A case-control study was conducted from 2000 to 2002 in six centers from Romania, Poland, Russia, Slovakia and the Czech Republic. Patients diagnosed with squamous cell carcinoma of the UADT (n = 811) and controls with a recent diagnosis of diseases unrelated to tobacco and alcohol (n = 1083) were recruited. For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009). Several other sequence variants showed associations with specific cancers without an overall association with UADT cancer. While some of these associations are consistent with previous studies, we cannot rule out the possibility of false-positive associations. The positive findings should be explored in another large-scale study on UADT cancers. © 2007 Oxford University Press.
Published: 2007

39. Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe

Author: Mia Hashibe, Dana Mates, Peter Rudnai, Paul Brennan, Eleonora Fabianova, Neonila Szeszenia-Dabrowska, Oxana Shangina, Paolo Boffetta, David Zaridze, Hashibe, M., Boffetta, P., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Fabiánová, E., Rudnai, P., and Brennan, P.
Subjects: Adult, Male, Larynx, Glottis, medicine.medical_specialty, Alcohol Drinking, Epidemiology, medicine.medical_treatment, Slovenia, Russia, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Humans, Laryngeal Neoplasms, Aged, Hungary, Romania, business.industry, Incidence, Incidence (epidemiology), Smoking, Cancer, Middle Aged, Laryngeal Neoplasm, medicine.disease, Contribution tobacco alcohol high rates squamous cell carcinoma supraglottis glottis Central Europe, Surgery, Logistic Models, medicine.anatomical_structure, Epidermoid carcinoma, Case-Control Studies, Supraglottic Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Smoking cessation, Female, Poland, business
Abstract: Incidence rates for laryngeal cancer in Central Europe are among the highest in the world. The authors recruited cases and controls between 2000 and 2002 for the Central and Eastern Europe Multicenter Study to investigate the role of tobacco and alcohol as causes of laryngeal cancer in this region. A total of 384 incident squamous cell cases were included, comprising 254 glottic and 108 supraglottic cancers. Hospital controls were chosen from within the same catchment area, from diseases unrelated to tobacco or alcohol (n = 918). Significant dose-response trends for frequency and duration of tobacco use were observed for both supraglottic and glottic cancers, with potentially a more important effect for supraglottic cancer. Quitting smoking was protective against laryngeal cancers after 5 years. Any increases in risk for alcohol drinking were generally moderate and nonsignificant. A greater than multiplicative interaction was observed between tobacco and alcohol on the risk of laryngeal cancer (p = 0.04). Approximately 87% of laryngeal cancer cases in Central Europe are attributable to tobacco use, of which 75% and 12% are due to current and past smoking, respectively. Approximately 39% are attributable to the interaction between alcohol and tobacco. Preventive efforts to encourage current smokers to quit are likely to be the most effective way to reduce the incidence of laryngeal cancer in this region. Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.
Published: 2007

40. Occupational exposure and laryngeal and hypopharyngeal cancer risk in Central and Eastern Europe

Author: Neonila Szeszenia-Dabrowska, Dana Mates, A t’Mannetje, Oxana Shangina, David Zaridze, Paolo Boffetta, Tony Fletcher, Paul Brennan, Eleonora Fabianova, Shangina, O., Brennan, P., Szeszenia-Dabrowska, N., Mates, D., Fabiánová, E., Fletcher, T., T'Mannetje, A., Boffetta, P., and Zaridze, D.
Subjects: Adult, Male, medicine.medical_specialty, Epidemiology, medicine.disease_cause, Asbestos, Occupational medicine, Hypopharyngeal Neoplasm, Internal medicine, Occupational Exposure, medicine, Humans, Europe, Eastern, Risk factor, Laryngeal Neoplasms, Aged, Hypopharyngeal Neoplasms, business.industry, Cancer, Hypopharyngeal cancer, Odds ratio, Laryngeal Neoplasm, Middle Aged, medicine.disease, Surgery, Case-Control Studies, Occupational exposures in risk of laryngeal/hypopharyngeal cancer, business
Abstract: A multicenter case-control study was conducted during 1999-2002 in four European countries (Poland, Romania, Russia, and Slovakia) to evaluate the role of occupational exposures in risk of laryngeal/hypopharyngeal cancer. Male cancer cases (34 hypopharyngeal, 316 laryngeal) with full data on occupational history and nonoccupational factors were compared with 728 hospital controls for occupational exposure to 73 suspected carcinogens. Occupational history was evaluated by industrial hygienists blinded to case/control status. Elevated risks for ever exposure to coal dust were found for both hypopharyngeal (odds ratio (OR) = 4.19, 95% confidence interval (CI): 1.18, 14.89) and laryngeal (OR = 1.81, 95% CI: 0.94, 3.47) cancer, with clear dose-response patterns. Inclusion of a 20-year lag in the analysis strengthened these associations. Hypopharyngeal cancer risk was also significantly associated with exposure to mild steel dust (OR = 3.04, 95% CI: 1.39, 6.64) and iron compounds and fumes (OR = 2.74, 95% CI: 1.29, 5.84), without clear dose-response relations. Laryngeal cancer was significantly associated with exposure to hard-alloys dust (OR = 2.23, 95% CI: 1.08, 4.57) and chlorinated solvents (OR = 2.18, 95% CI: 1.03, 4.61), without dose-response relations. A possible link between high formaldehyde exposure and laryngeal cancer was suggested. No association was found for exposure to asbestos or inorganic acid mists. These data indicate that occupational exposure to coal dust may play a role in laryngeal and hypopharyngeal cancer. Other possible relations need further evaluation. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.
Published: 2006

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