28 results on '"René Bakker"'
Search Results
2. The Contribution of Conceptual Independence to IT Infrastructure Flexibility
- Author
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Rogier van de Wetering, Debbie Tarenskeen, René Bakker, Sjaak Brinkkemper, Department of Information Science, and RS-Research Line Learning (part of LIRS program)
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Flexibility (engineering) ,Process management ,Standardization ,business.industry ,030503 health policy & services ,Health Policy ,media_common.quotation_subject ,Biomedical Engineering ,openEHR ,Adaptability ,03 medical and health sciences ,0302 clinical medicine ,Transparency (graphic) ,Health care ,Information technology management ,Information system ,030212 general & internal medicine ,0305 other medical science ,business ,media_common - Abstract
In the Netherlands demands on IT support in healthcare organizations are increasing. New visions on healthcare focus on patient-centered healthcare, where mutual consultation among healthcare professionals in the network becomes a standard process. Recent governmental regulations prescribe that patients must be able to access personal health records. IT flexibility is needed to allow organizations to meet new demands. In this study, we focus on Conceptual Independence (CI) be-cause CI, as a design principle, can improve the adaptability of Information Systems (IS). Software with CI operates on flexible data models that are independent of the CI based application. Therefore, it is claimed that a standalone IS becomes more flexible with CI. We extend the claim by demonstrating that CI affects the flexibility of the entire IT infrastructure. We investigate which dimensions of IT flexibility are responsible for the improvement. Multi-case study research has been performed following a mixed-methods approach in 10 mental healthcare organizations. Five have implemented openEHR, a proxy for CI, and five have not. Data has been collected with a questionnaire of IT infrastructure flexibility and semi-structured interviews. The data synthesis shows a positive effect of CI on IT flexibility, as CI increases the adaptability of IS, transparency and standardization of the IT infrastructure. Mean scores of openEHR organizations and other organizations on the questionnaire of IT infrastructure flexibility Mean scores of openEHR organizations and other organizations on the questionnaire of IT infrastructure flexibility … Reuse and modularity P2: Reuse of functionality increases Modularity of IT infrastructure Reuse and modularity P2: Reuse of functionality increases Modularity of IT infrastructure … Accessibility of data Accessibility of data … Mean Scores for Organizations on IT Infrastructure Flexibility Questionnaire Mean Scores for Organizations on IT Infrastructure Flexibility Questionnaire … Hypothesis Test Summary -Means Hypothesis Test Summary -Means … Figures - uploaded by Rogier van de WeteringAuthor content Content may be subject to copyright.
- Published
- 2020
3. Investigating the Impact of Outsourcing on IT Flexibility: The Conceptual Independence Perspective
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Deborah Tarenskeen, Rogier van de Wetering, René Bakker, Sjaak Brinkkemper, RS-Research Line Strategic design research (part of AIS program), Department of Information Science, and RS-Research Line Learning (part of LIRS program)
- Subjects
Information Systems and Management ,Medicine (miscellaneous) ,Information Systems - Abstract
Modern healthcare organizations try to leverage their IT infrastructures to enhance the efficiency of processes and the quality of patient services. The flexibility of the IT infrastructure is a critical factor in the process of establishing strategic and operational value. The authors examine how applied principles of Conceptual Independence (CI) in information systems (IS) influence the flexibility of IT infrastructures. Furthermore, it is presumed that IT outsourcing plays a role in IT flexibility. The second question asks whether IT outsourcing configurations change when CI has been applied or not. Quantitative and qualitative data have been collected in 9 mental healthcare organizations. Findings – based on integration of the data with a mixed-method approach - suggest that the healthcare organizations that apply the principles of CI are better equipped to adapt their IT infrastructure to changing demands, requests and needs. Likewise, results suggest that they have changed the government of IT outsourcing thereby increasing IT flexibility even further.
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- 2022
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4. Movin(g) Reality
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Carmen Ensink, Noël L.W. Keijsers, Theo Theunissen, and René Bakker
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medicine.medical_specialty ,Rehabilitation ,Cerebral vascular accident ,media_common.quotation_subject ,medicine.medical_treatment ,education ,05 social sciences ,050301 education ,After discharge ,Functioning level ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Gait (human) ,medicine ,Augmented reality ,medicine.symptom ,Function (engineering) ,Psychology ,0503 education ,030217 neurology & neurosurgery ,media_common ,Balance problems - Abstract
Many Cerebral Vascular Accident (CVA) patients suffer from gait and balance problems, which have a large impact on daily functioning. During clinical rehabilitation, a multidisciplinary team uses advanced training facilities to help patients regain optimal function. After discharge, however, CVA patients have difficulty to continue training to improve or even maintain their perceived functioning level. One of the limitations of at home training is that patients do not receive any feedback on their performance and progress. Feedback on the execution is important in CVA patients because sensorimotor feedback is disturbed. Moreover, feedback on the progress of their functioning level keeps the patients motivated. Within our project "Movin(g) Reality" we are developing two patterns: Train@Home, and Train2Go in addition to the already existing pattern Train@TheClinic.
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- 2020
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5. Dispelling the Blunt Perception of Social Technology
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René Bakker, J. Jeurens, and Koen van Turnhout
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Social sensitivity ,Computer science ,media_common.quotation_subject ,05 social sciences ,Perspective (graphical) ,Stakeholder ,Social environment ,020207 software engineering ,02 engineering and technology ,Social technology ,Participatory design ,Perception ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,Engineering ethics ,Engineering design process ,050107 human factors ,media_common - Abstract
Participatory design prescribes intensive stakeholder involvement in the design process. One challenge in such projects is to enable stakeholders to develop an open mind for novel solutions of the design problem at hand. When designing social technology, this is further complicated by prejudices about technology as being too blunt and inadequate to interfere with the sensitivity of social context. In this paper, we present a novel approach that supports a more neutral and open discussion on the benefits and pitfalls of social technology. The approach helps stakeholders see social technology in a broader perspective, which in turn enables the design of solutions with improved social sensitivity.
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- 2019
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6. Blending into the White Box of the Art Museum
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J. Jeurens, Ido Iurgel, Vera Lange, Marleen van Beuzekom, Tonguc Ibrahim Sezen, Jille Treffers, René Bakker, Willemiek van den Oever, Koen van Turnhout, M. Hansma, and M. Regterschot
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Operationalization ,Computer science ,Order (business) ,Aesthetics ,Face (sociological concept) ,White box ,Mixed reality - Abstract
Mixed reality applications can enrich museum exhibits and make them more attractive to an audience of adolescents. However, in the design of such applications, we face a myriad of possibilities and little guidance on how to choose between (early) alternatives. In this paper, we explore the notion of experience blend -which could act as an aesthetic governing the design of mixed reality experiences. We present an effort to operationalize experience blend and illustrate its use in the design and evaluation of an application for an art museum. Stakeholders in the project assumed that in order to reach out to adolescents an exciting experience was needed, deviating from education and breaking with the hidden rules of the art-museum, our user study showed that adolescents favored a blended experience. This suggests experience blend may be a helpful aesthetic in the design of other mixed reality experiences.
- Published
- 2019
7. A Top-Down Narrative Design Approach for Networked Cultural Institutions
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Tonguc Ibrahim Sezen, Ido Iurgel, Nicolas Fischöder, René Bakker, Digdem Sezen, and Koen van Turnhout
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Structure (mathematical logic) ,World Wide Web ,media_common.quotation_subject ,Interactive digital storytelling ,Narrative ,Top-down and bottom-up design ,Sociology ,Cultural institution ,Experience design ,Mobile device ,Diversity (politics) ,media_common - Abstract
In 2020 the RheijnLand.Xperiences project will connect 8 museums along the Dutch-German border by a network using a story-driven application for mobile devices for an audience between the ages of 14 and 22. While the project foresees the design of individually tailored experiences for each museum, an overarching narrative and experience structure is also required to establish connections between the museums. This structure relies heavily on the concepts of interactive digital storytelling and is required to compensate the environmental and thematic diversity of each museum while also enriching the overall experience of visiting multiple museums in the network. In this regard in this poster, we summarize our approach and core elements of the “universal” narrative and experience design.
- Published
- 2018
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8. Sub-3 mm, near-200 ps TOF/DOI-PET imaging with monolithic scintillator detectors in a 70 cm diameter tomographic setup
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Giacomo Borghi, Dennis R. Schaart, Valerio Tabacchini, and René Bakker
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Scanner ,Materials science ,time-of-flight positron emission tomography (TOF PET) ,Scintillator ,01 natural sciences ,Lyso ,Imaging phantom ,monolithic scintillator detector ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,digital silicon photomultiplier (dSiPM) ,0302 clinical medicine ,Optics ,Silicon photomultiplier ,0103 physical sciences ,Humans ,Radiology, Nuclear Medicine and imaging ,Image resolution ,point source image ,Photons ,Radiological and Ultrasound Technology ,010308 nuclear & particles physics ,business.industry ,Phantoms, Imaging ,Resolution (electron density) ,Detector ,Derenzo phantom image ,depth of interaction (DOI) ,Positron-Emission Tomography ,tomographic setup ,Scintillation Counting ,business - Abstract
Recently, a monolithic scintillator detector for time-of-flight (TOF)/depth-of-interaction (DOI) positron emission tomography (PET) was developed. It has a detector spatial resolution of ∼1.7 mm full-width-at-half-maximum (FWHM), a coincidence resolving time (CRT) of ∼215 ps FWHM, and ∼4.7 mm FWHM DOI resolution. Here, we demonstrate, for the first time, the imaging performance of this detector in a 70 cm diameter PET geometry. We built a tomographic setup representative of a whole-body clinical scanner, comprising two coaxially rotating arms, each carrying a detector module, and a central, rotating phantom table. The fully automated setup sequentially acquires all possible lines of response (LORs) of a complete detector ring, using a step-and-shoot acquisition approach. The modules contained 2 × 2 detectors, each detector consisting of a 32 mm × 32 mm × 22 mm LYSO crystal and a digital silicon photomultiplier (dSiPM) array. The system spatial resolution was assessed using a Na-22 point source at different radial distances in the field-of-view (FOV). Using 2D filtered back projection (2D FBP, non-TOF), tangential and radial spatial resolutions of ∼2.9 mm FWHM were obtained at the center of the FOV. The use of DOI information resulted in almost uniform spatial resolution throughout the FOV up to a radial distance of 25 cm, where the radial and tangential resolution are ∼3.3 mm FWHM and ∼4.7 mm FWHM, respectively, whereas without DOI the resolution deteriorates to ∼9 mm FWHM. Additional measurements were performed with a Na-22 filled Derenzo-like phantom at different locations within the FOV. Images reconstructed with a TOF maximum-likelihood expectation-maximization (TOF ML-EM) algorithm show that the system is able to clearly resolve 3 mm diameter hot rods up to 25 cm radial distance. The excellent and uniform spatial resolution, combined with an energy resolution of 10.2% FWHM and a CRT of ∼212 ps FWHM, indicates a great potential for monolithic scintillators as practical high-performance detectors in TOF/DOI-PET systems.
- Published
- 2018
9. The Healthy Elderly: Case Studies in Persuasive Design
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Koen van Turnhout, Jasper Jeurens, Martin Verhey, Pascal Wientjes, and René Bakker
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behavior change ,persuasive computing ,lcsh:T58.5-58.64 ,lcsh:Information technology ,social computing ,Computer Science Applications ,Education ,Human-Computer Interaction ,Architecture ,self-care ,Media Technology ,InformationSystems_MISCELLANEOUS ,Social Sciences (miscellaneous) ,co-creation - Abstract
Self-care and self-orchestration are focal points for transformations in health care and well-being in the Netherlands. Citizens should live healthily, be active every day and manage their own health. In this context, we explore how persuasive information technology may support older people in developing and maintaining healthy behavior. In two cases (in the Dutch cities Wijchen and Arnhem) we designed concepts of services in co-creation with professionals and citizens. These concepts were based on persuasive guidelines and positively tested with professionals and citizens. In this paper, we present these concepts and critically examine them in relation to existing literature on persuasive technology and personal informatics. We argue for backing persuasive interface with genuine support for user needs and for increasing the actionability of personal informatics solutions. The presented solutions also highlight how self-, family-, and professional care can be connected in the design of health support systems.
- Published
- 2015
10. Applying the V Model and Axiomatic Design in the Domain of IT Architecture Practice
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Stef Joosten, René Bakker, and Debbie Tarenskeen
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V Model ,Axiomatic design ,Enterprise architecture framework ,Engineering ,business.industry ,Enterprise architecture ,Functional software architecture ,Enterprise architecture management ,Applications architecture ,Systems engineering ,General Earth and Planetary Sciences ,IT Architecture practice ,Reference architecture ,View model ,business ,Enterprise Architecture ,General Environmental Science - Abstract
This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT systems in line with strategic goals. The research approach was to use a light modelling tool, Ampersand, for modelling the Enterprise architecture. Two types of models stand out: Type 1 Strategic IT models in which higher strategic goals are related to requirements for applications and Type 2 Technical management of systems models in which technical risks and risk of system failure in the current IT infrastructure were modelled. To bridge the views of different IT experts in the organization this work uses the customer domain, the functional domain and the physical domain from Axiomatic Design in an extended example in the paper. The V Model is used to bridge the models, and then it is extended with Axiomatic Design principles.
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- 2015
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11. Planning Spontaneity: A Case Study About Method Configuration
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van Turnhout Koen, Jan Henk Annema, van de Goor Judith, Jacobs Marjolein, and René Bakker
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- 2017
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12. Applying Axiomatic Design and Conceptual Independence in the Domain of IT Systems
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René Bakker and Debbie Tarenskeen
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System of systems ,Engineering ,Axiom independence ,Management science ,business.industry ,Functional requirement ,Business domain ,Axiomatic design ,Domain (software engineering) ,Risk analysis (engineering) ,lcsh:TA1-2040 ,Information system ,Independence (mathematical logic) ,lcsh:Engineering (General). Civil engineering (General) ,business - Abstract
In this paper we explain why Axiomatic design has not been applied in large system of systems information technology architectures in health care organizations in the Netherlands. We have found in extensive case studies of IT systems that the Independence axiom could not be found in the existing Information systems. This causes great concern for the adaptability of systems. Although best practices in system engineering advice decoupling of system functionality, findings show that the Independence Axiom has not been applied to functional requirements. A number of difficulties was exposed to the researcher and IT architects, when they tried to identify and to demarcate functional requirements in existing systems. In IT systems a distinction is made between business and system functions and software engineers emphasize decoupling of system functions. That has resulted in a strong coupling of business information and technical application logic. This means Conceptual dependencies are often at the heart of the difficulties. Decoupling these dependencies in applications seems a candidate for ordering requirements in a way that keeps the functional requirements independent from each other. Conceptual independence signifies a complete decoupling of the concepts and relations of the Business domain from the technical functionality. The paper describes the difficulties when applying the Independence Axiom in the Information systems domain and argues that a combination of Conceptual independence and Axiomatic design is achievable. The authors adapt the Design matrix with Conceptual independence. We conclude that applying Conceptual independence is crucial when constructing IT systems based on Axiomatic design. Components in Home care institute. Components in Home care institute. … . Descriptions of DPs. . Descriptions of DPs. … Figures - available via license: Creative Commons Attribution 4.0 International Content may be subject to copyright.
- Published
- 2017
13. RheijnLand.Xperiences – A Storytelling Framework for Cross-Museum Experiences
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Timo Kahl, Frank Zimmer, Koen van Turnhout, Ido Iurgel, and René Bakker
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Multimedia ,business.industry ,05 social sciences ,Design thinking ,Public relations ,Persuasive technology ,computer.software_genre ,050105 experimental psychology ,Mixed reality ,Digital media ,Order (business) ,0502 economics and business ,Co-creation ,050211 marketing ,0501 psychology and cognitive sciences ,Sociology ,business ,Implementation ,computer ,Storytelling - Abstract
In the Rhine-Waal region of Germany and the Netherlands eight, museums would like to engage adolescents and youngsters in museum visits. Using digital media, visitors should be warmed up, thrilled and get involved in storytelling deeply connected to these museums. Therefore, the project partners of RheijnLand.Xperiences (RLX) are developing a framework and several implementations that allow employing storylines for cross-organizational museum experiences. The key aspect of innovation is the creation of a “continuation network” of partner locations, where the visit to one location leads to the desire to continue the experience at a next location of the network. Therefore, it is mandatory to have junctures between the museums in order to facilitate the continuation. Apart from storytelling methods, several other concepts are being examined, such as “hyperportals”, “culture caching”, using good practices like persuasive technology and theoretic notions like “blended experience”, and “mixed reality”. In order to achieve that goal, RLX makes heavily use of innovation and user centered development methods, such as design thinking, idea generation, co-creation, early prototypes, aiming at setting exemplary methodological steps.
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- 2017
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14. Two countries, eight museums
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J. Jeurens, Marjolein Jacobs, M. Regterschot, Koen van Turnhout, and René Bakker
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Multimedia ,business.industry ,Computer science ,020207 software engineering ,02 engineering and technology ,computer.software_genre ,Mixed reality ,World Wide Web ,User experience design ,Order (business) ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Cross-cultural ,Position paper ,business ,computer - Abstract
Eight very versatile museums in the Rhine-Waal region, four in The Netherlands and four in Germany, see the opportunity to 'connect' in order to increase their visitors by creating a better experience before, during and after the visit. This enhanced experience encompasses the museum itself, its location, its artworks and its visitors and will be a mixed-reality blended experience with gamification elements, embedded in a network of museums. In this position paper we introduce our design program in-the-making (kickoff January 2017, expected) and highlight our approach. We propose that a museum should not only use the advantages of all possibilities surrounding IT and Media inside their own museum, but explicitly look outside - literally and figuratively - to trigger visitor engagement.
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- 2016
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15. Flipped Classroom Patterns
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René Bakker, Ralph Niels, Christian Köppe, and Stijn Hoppenbrouwers
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Value (ethics) ,Engineering ,Multimedia ,business.industry ,Knowledge level ,Control (management) ,computer.software_genre ,Flipped classroom ,Knowledge acquisition ,Work (electrical) ,Software design pattern ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,business ,computer ,Pace - Abstract
During the execution of a flipped classroom course, chances increase students are not at the level scheduled in the initial planning with some students falling behind with their knowledge acquisition and others running ahead. In those cases, adding value during the in-class meetings is much harder for teachers, as they have to take care of all the different knowledge levels. A good way of addressing this problem is to control the learning pace of the group. As a result, the knowledge level of the group will be more homogeneous which makes it easier to add value during the in-class meetings. In previous work we described the pattern Controlling the Pace. This pattern mainly addresses the course planning, but there are more aspects that need to be taken into account. In this paper we propose five patterns based on our experience that can help teachers to control the pace of student's learning in various aspects.
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- 2016
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16. FLIPPED ACTION LEARNING FOR HEALTHCARE PROFESSIONALS: PRINCIPLES AND DESIGN
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N. van Diepen, E. de Vries, M. Ruivenkamp, and René Bakker
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Engineering ,Knowledge management ,Health professionals ,business.industry ,Engineering ethics ,business ,Action learning - Published
- 2016
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17. Recovery of Normal Body Weight in Adolescents with Anorexia Nervosa: The Nurses' Perspective on Effective Interventions
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Laura Beukers, Berno van Meijel, Esther L. Meerwijk, René Bakker, Joyce van Ommen, and Annemarie A. van Elburg
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Research design ,medicine.medical_specialty ,Nursing research ,General Medicine ,Pediatrics ,Focus group ,Psychiatry and Mental health ,Social support ,Nursing care ,Anorexia nervosa (differential diagnoses) ,mental disorders ,medicine ,Nursing Interventions Classification ,Pshychiatric Mental Health ,Thematic analysis ,Psychology ,Psychiatry ,Clinical psychology - Abstract
PROBLEM: Little is known about effective nursing interventions for adolescents with anorexia nervosa. The purpose of this study was to discover which aspects of nursing care are most effective, according to nurses, in recovery of normal body weight in adolescents with anorexia nervosa. METHODS: A qualitative descriptive research design was applied with individual in-depth interviews and a focus group. Thematic analysis was used to analyze the data. FINDINGS: Nurses state that they are in a key position in guiding patients with anorexia nervosa toward a path of weight recovery. A good therapeutic relationship is essential to the implementation of targeted nursing interventions in the areas of eating and exercising, social support, and parent counseling. CONCLUSIONS: The results of this research can be used to define more detailed nursing interventions, the effectiveness of which can be tested in follow-up research.
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- 2011
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18. Flipped classroom patterns
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Ralph Niels, Christian Köppe, Lars Tijsma, Koen van Turnhout, Niek van Diepen, René Bakker, and Robert Holwerda
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Engineering ,Class (computer programming) ,Multimedia ,business.industry ,media_common.quotation_subject ,Role change ,computer.software_genre ,Bachelor ,Flipped classroom ,Learning programming ,Software design pattern ,ComputingMilieux_COMPUTERSANDEDUCATION ,Educational patterns ,business ,computer ,media_common - Abstract
The flipping classroom approach is directed at getting students well-prepared in class so that the valuable face-to-face time during the in-class meetings can be used more efficiently to support students' learning. This requires a radical change of the role of the lecturers, as they are not knowledge transmitters anymore but learning facilitators. This role change has direct impact on the design of the in-class-meetings.Based on five years of experience with flipped classrooms for learning programming in bachelor computing programs and on an educational and organization analysis, we started to collect and describe patterns that help with improving various aspects of Flipped Classrooms. In this paper we describe five patterns that help with the design and execution of in-class meetings in a Flipped Classroom course.
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- 2015
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19. Design patterns for mixed-method research in HCI
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Stijn Hoppenbrouwers, Dick Lenior, Marjolein Jacobs, Ralph Niels, Arthur Bennis, Lambert Zaad, Robert Holwerda, René Bakker, Sabine Craenmehr, and Koen van Turnhout
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Research design ,Human–computer interaction ,Computer science ,Multimethodology ,Software design pattern ,Software Science ,Literature study ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
In this paper we discuss mixed-method research in HCI. We report on an empirical literature study of the NordiCHI 2012 proceedings which aimed to uncover and describe common mixed-method approaches, and to identify good practices for mixed-methods research in HCI. We present our results as mixed-method research design patterns, which can be used to design, discuss and evaluate mixed-method research. Three dominant patterns are identified and fully described and three additional pattern candidates are proposed. With our pattern descriptions we aim to lay a foundation for a more thoughtful application of, and a stronger discourse about, mixed-method approaches in HCI.
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- 2014
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20. Increasing Family Involvement in Elderly Care
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J. Jeurens, René Bakker, and Koen van Turnhout
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Cohesion (linguistics) ,Gerontology ,Family involvement ,business.industry ,Health care ,Elderly care ,Extended family ,Narrative ,Psychology ,Persuasive technology ,business - Abstract
This paper describes the design and field trial of the Dynamic Collage, a system which aims support extended family members to take part in the care for an elderly person in a light way manner by sending photos to a digital frame in the elderly home. We evaluated the dynamic collage in a field trial of 4-6 weeks with two families, yielding positive results. Photo-sharing was seen as a valuable contribution by the elderly person and all family members, it provided narrative support for visitors of the elderly and it led to an increased awareness of caregiving behavior and increased cohesion in the family. The study shows there is an opportunity to include Awareness Systems and Persuasive Technology within a participation ecology, which could be beneficial for health care.
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- 2014
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21. Tradeoffs in Design Research: Development Oriented Triangulation
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Koen van Turnhout, Sabine Craenmehr, Robert Holwerda, Mike Menijn, Jan-Pieter Zwart, and René Bakker
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- 2013
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22. Redesign of technical systems
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F. Dikker, S.J.M. van Eldonk, P.M. Wognum, René Bakker, and L.K. Alberts
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Engineering design ,Information Systems and Management ,Model-based diagnosis ,business.industry ,Computer science ,Technical systems ,Ontology (information science) ,Management Information Systems ,Artificial Intelligence ,Formal specification ,Adaptation (computer science) ,Engineering design process ,Software engineering ,business ,Software - Abstract
The paper describes a systematic approach to support the redesign process. Redesign is the adaptation of a technical system in order to meet new specifications. The approach presented is based on techniques developed in model-based diagnosis research. The essence of the approach is to find the part of the system which causes the discrepancy between a formal specification of the system to be designed and the description of the existing technical system. Furthermore, new specifications are generated, describing the new behaviour for the `faulty¿ part. These specifications guide the actual design of this part. Both the specification and design description are based on YMIR, an ontology for structuring engineering design knowledge.
- Published
- 1996
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23. Measurement of affinity in serum samples of antigen-free, germ-free and conventional mice after hyperimmunization with 2,4-dinitrophenyl keyhole limpet hemocyanin, using surface plasmon resonance
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Edwin Lasonder, Nicolaas A. Bos, and René Bakker
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Immunology ,Spleen ,Hyperimmunization ,Mice ,chemistry.chemical_compound ,Immune system ,Antigen ,medicine ,Animals ,Germ-Free Life ,Immunology and Allergy ,B-Lymphocytes ,Mice, Inbred BALB C ,biology ,Molecular biology ,medicine.anatomical_structure ,chemistry ,Polyclonal antibodies ,Immunoglobulin G ,Antibody Formation ,Hemocyanins ,biology.protein ,Immunization ,Dinitrophenyl ,Antibody ,Keyhole limpet hemocyanin - Abstract
We previously investigated the primary and secondary responses and hyperimmunization to the T cell-dependent antigen 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH) in antigen-free (AF), germ-free (GF) and conventional (CV) mice. Both the absolute and relative numbers of DNP-specific IgG-secreting cells in the spleen of AF mice were considerably higher compared to GF and CV mice, especially after hyperimmunization. In the present study we measured the total and DNP-specific IgG concentration in the sera of these hyperimmunized mice using a sensitive sandwich enzyme-linked immunosorbent assay. With respect to the total IgG concentration before and after hyperimmunization, the AF mice showed an almost 13-fold increase after boosting with the antigen; the GF mice showed an approximately 8-fold increase. A slight but non-significant increase was observed in the CV mice. The total as well as the DNP-specific IgG levels in the AF-immunized mice were 2-fold and 5-fold higher compared to GF and CV mice, respectively. With the use of Surface Plasmon Resonance instrumentation (BIAcore(TM), Pharmacia, Uppsala, Sweden) we obtained mean binding affinities (K-A) of the polyclonal samples of the three groups of hyperimmunized mice. IgA and IgM samples displayed low affinity for DNP-lysine. The AF mice displayed the highest K-A value among IgG antibodies, followed by GF mice, while CV mice showed a 3-fold lower K-A compared to AF mice. These differences were mainly determined by the dissociation rate constant (k(diss)), since no significant changes were observed in the association rate constant (k(ass)). Furthermore, the sera of the CV mice have a lower percentage of high-affinity antibodies compared to GF and AF mice. These results suggest that besides a higher overall binding affinity seen in AF mice, and to a lesser extent in GF mice, the relative contribution of high-affinity IgG is greater in AF mice compared to CV mice.
- Published
- 1995
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24. 'On the construction of hierarchic models'
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R. P. van Rikxoort, D.J. Out, and René Bakker
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Artificial neural network ,Computer science ,business.industry ,Process (engineering) ,Applied Mathematics ,Technical systems ,Complex system ,Diagnostic algorithms ,computer.software_genre ,Machine learning ,Field (computer science) ,Nonlinear system ,Artificial Intelligence ,Data mining ,Artificial intelligence ,business ,Time complexity ,computer - Abstract
One of the main problems in the field of model-based diagnosis of technical systems today is finding the most useful model or models of the system being diagnosed. Often, a model showing the physical components and the connections between them is all that is available. As systems grow larger and larger, the run-time performance of diagnostic algorithms decreases considerably when using these detailed models. A solution to this problem is using a hierarchic model. This allows us to first diagnose the system using an abstract model, and then use this solution to guide the diagnostic process using a more detailed model. The main problem with this approach is acquiring the hierarchic model. We give a generic hierarchic diagnostic algorithm and show how the use of certain classes of hierarchic models can increase the performance of this algorithm. We then present linear time algorithms for the automatic construction of these hierarchic models, using the detailed model and extra information about cost of probing points and invertibility of components.
- Published
- 1994
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25. Recovery of normal body weight in adolescents with anorexia nervosa: the nurses' perspective on effective interventions
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René, Bakker, Berno, van Meijel, Laura, Beukers, Joyce, van Ommen, Esther, Meerwijk, and Annemarie, van Elburg
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Adult ,Counseling ,Male ,Parents ,Anorexia Nervosa ,Adolescent ,Attitude of Health Personnel ,Body Weight ,Nurses ,Social Support ,Psychiatric Nursing ,Feeding Behavior ,Recovery of Function ,Focus Groups ,Interviews as Topic ,Nursing Research ,Body Composition ,Humans ,Female ,Exercise - Abstract
Little is known about effective nursing interventions for adolescents with anorexia nervosa. The purpose of this study was to discover which aspects of nursing care are most effective, according to nurses, in recovery of normal body weight in adolescents with anorexia nervosa. A qualitative descriptive research design was applied with individual in-depth interviews and a focus group. Thematic analysis was used to analyze the data. Nurses state that they are in a key position in guiding patients with anorexia nervosa toward a path of weight recovery. A good therapeutic relationship is essential to the implementation of targeted nursing interventions in the areas of eating and exercising, social support, and parent counseling. The results of this research can be used to define more detailed nursing interventions, the effectiveness of which can be tested in follow-up research.
- Published
- 2011
26. Issues in practical model-based diagnosis
- Author
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P.C.A. van den Bempt, René Bakker, D.-J. Out, Nicolaas Mars, and D.C. van Soest
- Subjects
Model-based diagnosis ,Operations research ,SIMPLE (military communications protocol) ,Computer Networks and Communications ,business.industry ,Computer science ,Modeling ,Reuse ,Model-based reasoning ,Computational efficiency ,Tools ,Technical feasibility ,Hardware and Architecture ,Software engineering ,business ,Software - Abstract
The model-based diagnosis project at the University of Twente has been directed at improving the practical usefulness of model-based diagnosis. In cooperation with industrial partners, the research addressed the modeling problem and the efficiency problem in model-based reasoning. Main results of this research are that (1) re-use of electronically available descriptions of systems for diagnostic purposes is possible, and (2) efficient reasoning can be realized using PDE, hierarchic models, and a simple diagnostic strategy. We have built a prototype diagnostic system which shows the technical feasibility of model-based diagnosis in a computer system. The project was concluded in July 1993 by the development of the `Diagnostic Toolbox?. The Diagnostic Toolbox supports the modeling of technical systems for diagnostic purposes, and it contains several model-based reasoning methods.
- Published
- 1993
- Full Text
- View/download PDF
27. Reusing design information for model-based diagnosis
- Author
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René Bakker, Nicolaas Mars, and Dick C. van Soest
- Subjects
Computer science ,Process (engineering) ,Carry (arithmetic) ,Model-based design ,Data mining ,Reuse ,Medical diagnosis ,Fault (power engineering) ,computer.software_genre ,computer ,Field (computer science) - Abstract
Model-based diagnosis (MBD) is a technique to locate faults in a system with the aid of a model of that system. The model describes the correct behavior of the system, and possibly also the behavior in case of a fault. In the field of model-based diagnosis, most attention has been given to the problem of reasoning: how to derive diagnoses, given a model. When applying MBD in practice, modeling appears to be a problem of equal magnitude. In this paper, we analyze the modeling process, and show how design information can be used in this process. We investigated the use of information in two standard languages for information interchange: EDIF and VHDL. We expect that the results from this research carry over to other design formats.
- Published
- 1993
- Full Text
- View/download PDF
28. A theory of decisional power
- Author
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C. Hoede and René Bakker
- Subjects
Algebra and Number Theory ,Sociology and Political Science ,Social network ,business.industry ,media_common.quotation_subject ,Democracy ,Power (social and political) ,Power over ,State (polity) ,Dictator ,Artificial intelligence ,business ,Mathematical economics ,Social Sciences (miscellaneous) ,Mathematics ,media_common - Abstract
The concept of decisional power is introduced and compared with other measures for power like those of Shapley‐Shubik, Banzhaf and Dahl. The sum of the powers of all actors in a social network is maximal for certain structures of the network. These structures are called completely democratic. Completely democratic structures are characterized. In every network dictator sets are present. These can be found by use of Boole polynomials. Decisional power turns out to‐have both a causal aspect and a utility aspect and to allow for variations that express the power over other persons as well as the power in a certain state of the network.
- Published
- 1982
- Full Text
- View/download PDF
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