1. Clinical characteristics and outcomes of patients with pediatric acute lymphoblastic leukemia after induction of chemotherapy: a pilot descriptive correlational study from Palestine
- Author
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Ramzi Shawahna, Sultan Mosleh, Majd Al-Ghoul, Yahya Odeh, and Rami Halawa
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Palestine ,Science (General) ,Neutrophils ,QH301-705.5 ,medicine.medical_treatment ,Translocation ,Chromosomal translocation ,Acute lymphoblastic leukemia ,General Biochemistry, Genetics and Molecular Biology ,Translocation, Genetic ,03 medical and health sciences ,Leukocyte Count ,Q1-390 ,0302 clinical medicine ,Pediatric Acute Lymphoblastic Leukemia ,Internal medicine ,Medicine ,Humans ,Biology (General) ,Child ,Chemotherapy ,business.industry ,Remission Induction ,Cytogenetics ,Cancer ,Induction chemotherapy ,General Medicine ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Treatment ,Research Note ,030104 developmental biology ,030220 oncology & carcinogenesis ,Hyperdiploidy ,business - Abstract
Objective Pediatric acute lymphoblastic leukemia (ALL) is the most prevalent type of cancer among children. This study was conducted to describe and correlate the clinical characteristics and outcomes of treatment of patients with pediatric ALL in the main referral hospital in Palestine. Results Complete data of 69 patients were included in this analysis. The majority (79.7%) of the patients had B-ALL phenotype. After induction chemotherapy, remission was experienced by the vast majority of the patients and 5 (7.2%) experienced relapses. Cytogenetics for patients with B-ALL phenotype indicated that 10 (18.2%) patients had t(12, 21) translocation, 5 (9.1%) had hyperdiploidy, 4 (7.3%) had t(1, 19) translocation, and 2 (3.6%) had t(9, 22) translocation. The initial white blood cells (p value
- Published
- 2021