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2 results on '"Perkins, Darren J."'

1. sj-pdf-1-ini-10.1177_1753425920975082 - Supplemental material for cAMP levels regulate macrophage alternative activation marker expression

Author

Swamy Polumuri, Perkins, Darren J, and Vogel, Stefanie N

Subjects
FOS: Clinical medicine, 110306 Endocrinology
Abstract

Supplemental material, sj-pdf-1-ini-10.1177_1753425920975082 for cAMP levels regulate macrophage alternative activation marker expression by Swamy Polumuri, Darren J Perkins and Stefanie N Vogel in Innate Immunity

Published
2020
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2. Type I interferon Licenses Enhanced Innate Recognition and Transcriptional Responses to Franciscella tularensis LVS

Author

Richard, Katharina, Vogel, Stefanie N., and Perkins, Darren J.

Subjects
Transcription, Genetic, Inflammasomes, Macrophages, Interleukin-1beta, Interferon-beta, Article, Immunity, Innate, Toll-Like Receptor 2, Mice, Inbred C57BL, Mice, RAW 264.7 Cells, Organ Specificity, Myeloid Differentiation Factor 88, Macrophages, Peritoneal, Animals, Humans, Francisella tularensis, Tularemia
Abstract

The innate inflammatory response to Francisella tularensis (Ft) in macrophages is significantly governed by the expression of type I interferons (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ft infection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages, but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.

Published
2016

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