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Type I interferon Licenses Enhanced Innate Recognition and Transcriptional Responses to Franciscella tularensis LVS
- Publication Year :
- 2016
-
Abstract
- The innate inflammatory response to Francisella tularensis (Ft) in macrophages is significantly governed by the expression of type I interferons (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ft infection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages, but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid..........9104ae60fba0d03c1afaca3969a834d8