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Hee Seon Choi,1Young Hye Cho,1Sang Yeoup Lee,1Eun Ju Park,1Yun Jin Kim,2,3Jeong Gyu Lee,2,3Yu Hyeon Yi,2,3Young Jin Tak,2,3Hye Rim Hwang,2,3Seung Hun Lee2,3 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 50612, South Korea; 2Department of Family Medicine, Pusan National University School of Medicine, Yangsan 626-780, South Korea; 3Department of Family Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, South KoreaCorrespondence: Young Hye ChoFamily Medicine Clinic, Obesity, Metabolism and Nutrition Center and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, South KoreaTel +82 51 240 7707Fax +82 51 240 7843Email younghey82@naver.comBackground: Obesity is an important risk factor of cardiovascular disease (CVD). Atherosclerosis can be considered an important signal of CVD. Primary physicians can reduce the risk of CVD by preventing and treating obesity. Therefore, finding a tool to diagnose the association of obesity with arteriosclerosis is important. The association between obesity parameters and arterial stiffness remains controversial. To our knowledge, no previous studies reported the relationships between multiple new anthropometric parameters (a body shape index [ABSI], body round index [BRI], and visceral adiposity index [VAI]) and brachial-ankle wave velocity (ba-PWV) as an indicator of CVD risk, especially in the Korean population.Objective: To investigate the relationships between arterial stiffness (assessed using ba-PWV) and anthropometric parameters estimated on the basis of body mass index (BMI), waist circumference (WC), ABSI, BRI, and VAI, and to identify the indicators of obesity that best represents CVD risk.Methods: A total of 2,647 adults (1,474 men and 1,173 women) were recruited for this cross-sectional study. The correlations between the anthropometric indexes (BMI, WC, ABSI, BRI, and VAI) and mean ba-PWV were analyzed. Amultivariate linear regression analysis was performed to evaluate the association between each anthropometric and the presence of arterial stiffness.Results: We investigated the relationships between the obesity parameters and ba-PWV by adjusting the covariates (age, diabetes mellitus [DM], hypertension [HTN], and smoking status) related to the mean ba-PWV. In the multivariate regression analysis, ABSI (men: β =0.066, p

Soo Min Son,1 Eun-Ju Park,1 Young Hye Cho,1 Sang Yeoup Lee,1 Jung-In Choi,1 Young-In Lee,1 Yun Jin Kim,2 Jeong Gyu Lee,2 Yu Hyeon Yi,2 Young Jin Tak,2 Hye Rim Hwang,2 Seung-Hun Lee,2 Ryuk Jun Kwon,1 Choongrak Kim3 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 50612, South Korea; 2Department of Family Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, South Korea; 3Department of Statistics Pusan National University, Busan 609-735, South KoreaCorrespondence: Eun-Ju ParkMedical of Family Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612 Tel +82-55-360-2140Fax +82-55-360-2170Email everblue124@hanmail.netBackground: Many researchers have identified that adequate sleep duration is linked to the quality of life and metabolic diseases. Nowadays, it is hard to take enough sleep, so weekend catch-up sleep (CUS) may be an alternative option in modern society. To our knowledge, no previous studies reported the association between weekend CUS and metabolic syndrome, especially in the Korean population.Objective: We investigated the association between weekend CUS and the prevalence of metabolic syndrome in Korean adults (≥ 20 years old) with less than 6 hours of average weekday sleep.Patients and Methods: A total of 1,453 individuals were selected from the Korean National Health and Nutrition Examination Survey. Weekend CUS was divided into four categories: ≤ 0 hour, 0– 1 hour, 1– 2 hours, and ≥ 2 hours. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived by univariate and multivariate logistic regression analyses.Results: Participants with weekend CUS ≥ 1 hour had decreased risk of metabolic syndrome in univariate analysis (CUS 1– 2 hours: OR: 0.413, 95% CI: 0.301– 0.568; CUS ≥ 2 hours: OR: 0.382, 95% CI 0.296– 0.493). Weekend CUS 1– 2 hours reduced the risk of metabolic syndrome in multivariate logistic regression analysis (OR: 0.552, 95% CI: 0.369– 0.823). Based on the age group analysis, weekend CUS ≥ 1 hour reduced the metabolic syndrome among those aged 20– 39 and 40– 65 (20– 39: CUS 1– 2 hours OR: 0.248, 95% CI: 0.078– 0.783, CUS ≥ 2 hours OR: 0.374, 95% CI: 0.141– 0.991; 40– 65: CUS 1– 2 hours OR: 0.507, 95% CI 0.309– 0.832 CUS ≥ 2 hours OR: 0.638, 95% CI: 0.415– 0.981).Conclusion: Weekend CUS was associated with a low risk of metabolic syndrome among Korean adults with sleep restriction.Keywords: sleep recovery, sleep deprivation, metabolic syndrome, insulin sensitivity

Supplemental Material, Appendix_table_AD-1_20190112 for Feasibility of Early Application of an Advance Directive at the Time of First-Line Palliative Chemotherapy in Patients With Incurable Cancer: A Prospective Study by Eun-Ju ParK, Yeon Jae Lim, Jae-Joon Kim, Sang-Bo Oh, So Yeon Oh, and Kwonoh Park in American Journal of Hospice and Palliative Medicine®

【[ ${\beta}-W(W_3O)$ ] oxide layer on the surface of each W(tungsten) nanopowder produced by the electric explosion of wire(EEW) process were formed during the 1vol.% air passivation process. The oxide layer hindered sintering densification of compacts during SPS process. The oxide phase was reduced to the pure W phase during SPS. The W nanopowder's compacts treated by the hydrogen reduction showed high sintered density of 94.5%. after SPS process at $1900^{\circ}C$ .】

Poly(ethylene glycol) methacrylate-based hydrogels containing, thiol reactive maleimide functional groups have been synthesized using a novel Diels-Alder cycloaddition/cycloreversion-based strategy. Masked maleimide groups are directly incorporated into the hydrogel matrix during the gelation process by utilization of a furan protected maleimide containing methacrylate monomer. During the polymerization, the thermal deprotection of the maleimide groups in some of the monomer results in the formation of an in situ cross-linker that results in gelation. After gelation, the protected maleimide groups can be activated to their reactive forms via a thermal cycloreversion step. The efficiency of the gel formation, maleimide incorporation, and functionalization of the hydrogel were investigated. These reactive maleimide group embedded hydrogels can be efficiently derivatized with thiol containing molecules such as a fluorescent dye, BodipyC10SH. Thiolated biotin derivatives were covalently attached to these hydrogels under mild, reagent-free conditions. It was found that the extent of immobilization of FITC-streptavidin onto these biotinylated gels can be tailored by varying the density of maleimide groups in the parent hydrogels.

Case Study, INSEAD Case 01/2008-5463

Case Study, INSEAD Case 11/2007-5488; The case focuses on LG Electronics' entry into the US market and its efforts to develop a premium brand, highlighting the specific instance of refrigerators which played a key role in the establishment of the firm's image. Entering the world's largest market proves to be a formidable challenge, particularly in a category that is mature and when the entrant is from a newly industrialised country in Asia, namely Korea. The case reveals how LG Electronics went about trying to establish a premium brand image in the US, following a series of earlier failed attempts. It allows for a discussion of key issues around customer focus, organisational characteristics and organisational alignment in successfully entering and establishing oneself in a new market.