Search

Additional file 1: Fig S1. Principal Component Analysis of East African and 1000 Genome Project. Fig S2. ADMIXTURE analysis across K values 2-12. Fig S3. Genomic context of tQTLs. Fig S4. π1 of eQTL p-values of SNP-gene pairs ascertained as sQTLs. Fig S5. π1 between sQTLs and eQTLs across gene length deciles. Fig S6. π1 value of ascertained eQTLs and sQTLs in GTEx. Fig S7. Mapping statistics from STAR. Fig S8. Frequency and LD differences between African samples and 1000 Genomes EURpopulations. Fig S9. tQTL effect size vs MAF. Fig S10. Fraction of FST outliers among eQTLs and sQTLs compared with matched background. Fig S11. Population-specific FST outliers. Fig. S12. Global frequencies of SNPs associated with pigmentation variation and TMEM216 expression and splicing. Fig S13. Colocalization of Mursi PBS and d-statistics with TMEM216 eQTLs. Fig S14. Colocalization of Mursi PBS and d-statistics with pigmentation GWAS. Fig S15. eQTL associations for TMEM216 across populations. Fig S16. ‘LocusCompare’ plots of African pigmentation GWAS and GTEx v8 eQTLs. Fig S17. ‘LocusCompare’ plots of African pigmentation GWAS and GTEx v8 sQTLs.

Additional file 3. Reviewhistory.

The inhibition titers of sera from adult residents in Dar es Salaam, Tanzania to intraerythrocytic growth of Plasmodium falciparum were not correlated to their antibody titers by immunofluorescence and enzyme immunoassay, and did not exhibit specificity to the strain with a certain MSA-1 gene. Another inhibitory factor (s) was found in a low molecular fraction with molecular weight less than 30,000 that was separated from a high molecular fraction by centrifugation on a meriibrane filter (centriprep-30, Amicon). This factor induced morphological changes of intraerythrocytic parasites and was thought to correspond to crisis form factor (CFF) by Jensen et al.(1982). The factor was shown to remain in the serum of an adult Tanzanian who had lived in a non-malarious area six months prior to the commencement of this study and to be contained in a hyperimmune serum from a Japanese patient even though on a low level, 日本熱帯医学会雑誌, vol.22(4), pp.211-215; 1994