タンザニアの免疫血清による熱帯熱マラリア原虫の試験管内増殖阻害

The inhibition titers of sera from adult residents in Dar es Salaam, Tanzania to intraerythrocytic growth of Plasmodium falciparum were not correlated to their antibody titers by immunofluorescence and enzyme immunoassay, and did not exhibit specificity to the strain with a certain MSA-1 gene. Another inhibitory factor (s) was found in a low molecular fraction with molecular weight less than 30,000 that was separated from a high molecular fraction by centrifugation on a meriibrane filter (centriprep-30, Amicon). This factor induced morphological changes of intraerythrocytic parasites and was thought to correspond to crisis form factor (CFF) by Jensen et al.(1982). The factor was shown to remain in the serum of an adult Tanzanian who had lived in a non-malarious area six months prior to the commencement of this study and to be contained in a hyperimmune serum from a Japanese patient even though on a low level
日本熱帯医学会雑誌, vol.22(4), pp.211-215; 1994