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1. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Author

Lohard, Steven, Bourgeois, Nathalie, Maillet, Laurent, Gautier, Fabien, Fétiveau, Aurélie, Lasla, Hamza, Nguyen, Frédérique, Vuillier, Céline, Dumont, Alison, Moreau-Aubry, Agnès, Frapin, Morgane, David, Laurent, Loussouarn, Delphine, Kerdraon, Olivier, Campone, Mario, Jézéquel, Pascal, Juin, Philippe P., Barillé-Nion, Sophie, Stress Adaptation and Tumor Escape in Breast Cancer (CRCINA-ÉQUIPE 8), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Site de Recherche Intégrée sur le Cancer - SIRIC « ILIAD » [Nantes] (INCA-DGOS-Inserm), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Université de Nantes (UN)-Université de Nantes (UN), Structure fédérative de recherche François Bonamy (SFR François Bonamy), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN), Service d'Anatomie Pathologique [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre Hospitalier Universitaire G. R. Laennec (HGRL Saint-Herblain), This work was supported by the Ligue contre le Cancer (44, 22, 53, 56, and 85), the Canceropole Grand Ouest, the Region Pays de la Loire (MATURE project 2017–18) and the Agence Nationale de la Recherche (Grands defis societaux 2015–2020, Antinetrex project)., Stress Adaptation and Tumor Escape in breast cancer - SATE (CRCINA - Département ONCO - Equipe 8), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Institut de cancérologie de l'Ouest - Nantes (ICO Nantes), CRLCC Paul Papin-CRLCC René Gauducheau, Regulation of Bcl2 and p53 networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA - Département NOHMAD - Equipe 10), Physiologie des Adaptations Nutritionnelles [UMR_A1280] (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Bernardo, Elizabeth, and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
Cell death, Cell biology, Paclitaxel, Science, bcl-X Protein, Apoptosis, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antimitotic Agents, Article, Cell Line, Gene Knockout Techniques, Mice, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Paracrine Communication, Tumor Cells, Cultured, Animals, Humans, lcsh:Science, Cancer, Tumor Necrosis Factor-alpha, Membrane Proteins, Nucleotidyltransferases, Xenograft Model Antitumor Assays, Proto-Oncogene Proteins c-bcl-2, Interferon Type I, lcsh:Q, Female, Signal Transduction
Abstract

A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory phenotype is induced by activation of cGAS/STING in cancer cells that are hit by antimitotic treatment, accumulate micronuclei and maintain mitochondrial integrity despite intrinsic apoptotic pressure. Organotypic cultures of primary human breast tumors and patient-derived xenografts sensitive to paclitaxel exhibit gene expression signatures typical of type I IFN and TNFα exposure. These cytokines induced by cGAS/STING activation trigger NOXA expression in neighboring cells and render them acutely sensitive to BCL-xL inhibition. cGAS/STING-dependent apoptotic effects are required for paclitaxel response in vivo, and they are amplified by sequential, but not synchronous, administration of BH3 mimetics. Thus anti-mitotic agents propagate apoptotic priming across heterogeneously sensitive cancer cells through cytosolic DNA sensing pathway-dependent extracellular signals, exploitable by delayed MOMP targeting., Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.

Published
2020

2. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Author

Lohard, Steven, Bourgeois, Nathalie, Maillet, Laurent, Gautier, Fabien, Fétiveau, Aurélie, Lasla, Hamza, Nguyen, Frédérique, Vuillier, Céline, Dumont, Alison, Moreau-Aubry, Agnès, Frapin, Morgane, David, Laurent, Loussouarn, Delphine, Kerdraon, Olivier, Campone, Mario, Jézéquel, Pascal, Juin, Philippe P., and Barillé-Nion, Sophie

Subjects
Médecine humaine et pathologie, Human health and pathology
Abstract

A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively primecancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), whileimpacting only on cycling cell subsets. Here, we show that a proapoptotic secretory phe-notype is induced by activation of cGAS/STING in cancer cells that are hit by antimitotictreatment, accumulate micronuclei and maintain mitochondrial integrity despite intrinsicapoptotic pressure. Organotypic cultures of primary human breast tumors and patient-derived xenografts sensitive to paclitaxel exhibit gene expression signatures typical of type IIFN and TNFαexposure. These cytokines induced by cGAS/STING activation trigger NOXAexpression in neighboring cells and render them acutely sensitive to BCL-xL inhibition.cGAS/STING-dependent apoptotic effects are required for paclitaxel response in vivo, andthey are amplified by sequential, but not synchronous, administration of BH3 mimetics.Thus anti-mitotic agents propagate apoptotic priming across heterogeneously sensitivecancer cells through cytosolic DNA sensing pathway-dependent extracellular signals,exploitable by delayed MOMP targeting.

Published
2020

3. Supplementary_methods_1 – Supplemental material for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer

Author

Dagher, Elie, Simbault, Laura, Abadie, Jérôme, Loussouarn, Delphine, Campone, Mario, and Nguyen, Frédérique

Subjects
FOS: Clinical medicine, Cell Biology, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_methods_1 for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer by Elie Dagher, Laura Simbault, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen in Tumor Biology

Published
2020
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4. SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human

Author

Etienne, Floriane, Berthaud, Maxime, Nguyen, Frédérique, Bernardeau, Karine, Maurel, Catherine, Bodet-Milin, Caroline, Diab, Maya, Abadie, Jérôme, Gouilleux-Gruart, Valérie, Vidal, Aurélien, Bourgeois, Mickael, Chouin, Nicolas, Ibisch, Catherine, Davodeau, François, Oncologie nucléaire (CRCINA - Département NOHMAD - Equipe 13), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Animaux Modèles pour la Recherche en Oncologie [Nantes] (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Stress Adaptation and Tumor Escape in breast cancer - SATE (CRCINA - Département ONCO - Equipe 8), Plateforme 'Production de protéines recombinantes' (P2R - INSERM UMS016/CNRS UMS3556/UN FED4203), Structure fédérative de recherche François Bonamy (SFR François Bonamy), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN), Service de Médecine Nucléaire [Nantes], Hôpital Laennec, Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours, Cyclotron ARRONAX [Saint-Herblain], ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), This work was supported by the Institut Thématique MultiOrganismes (ITMO) Cancer of the Alliance pour les sciences de la vie et de la santé (AVIESAN) jointly with the Institut National du Cancer (INCA) under one grant entitled: Spontaneous tumor models in animals for translational research in oncology no. A11196NS (CANIMAB). Financial support was also provided by a Physics, Mathematics and Engineering sciences applied to the Cancer Research grant (DogPPK project) awarded by INSERM and INCa., Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Animaux modèles pour la recherche en oncologie comparée (AMaROC), Stress Adaptation and Tumor Escape in Breast Cancer (CRCINA-ÉQUIPE 8), Université de Tours (UT), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Bernardo, Elizabeth

Subjects
comparative oncology, diffuse large B-cell lymphoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, SPECT-CT imaging, internalization, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, immune system diseases, monoclonal antibody, hemic and lymphatic diseases, dog, internalization Etienne et al Radiolabeled Anti-canine CD22 Antibodies, CD22, Original Research
Abstract

International audience; Antibodies directed against CD22 have been used in radioimmunotherapy (RIT) clinical trials to treat patients with diffuse large B-cell lymphoma (DLBCL) with promising results. However, relevant preclinical models are needed to facilitate the evaluation and optimization of new protocols. Spontaneous DLBCL in dogs is a tumor model that may help accelerate the development of new methodologies and therapeutic strategies for RIT targeting CD22. Seven murine monoclonal antibodies specific for canine CD22 were produced by the hybridoma method and characterized. The antibodies' affinity and epitopic maps, their internalization capability and usefulness for diagnosis in immunohistochemistry were determined. Biodistribution and PET imaging on a mouse xenogeneic model of dog DLBCL was used to choose the most promising antibody for our purposes. PET-CT results confirmed biodistribution study observations and allowed tumor localization. The selected antibody, 10C6, was successfully used on a dog with spontaneous DLBCL for SPECT-CT imaging in the context of disease staging, validating its efficacy for diagnosis and the feasibility of future RIT assays. This first attempt at phenotypic imaging on dogs paves the way to implementing quantitative imaging methodologies that would be transposable to humans in a theranostic approach. Taking into account the feedback of existing human radioimmunotherapy clinical trials targeting CD22, animal trials are planned to investigate protocol improvements that are difficult to consider in humans due to ethical concerns.

Published
2020

8. Production and characterization of monoclonal antibodies specific for canine CD138 (syndecan-1) for nuclear medicine preclinical trials on spontaneous tumours

Author

Diab, Maya, Nguyen, Frédérique, Berthaud, Maxime, Maurel, Catherine, Gaschet, J., Verger, Elise, Ibisch, Catherine, Chérel, Michel, Abadie, Jérôme, Davodeau, François, Rousseau, Caroline, Bernardo, Elizabeth, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)

Subjects
Mammary Neoplasms, Animal, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mice, Dogs, breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, immune system diseases, hemic and lymphatic diseases, Animals, Humans, Dog Diseases, Mice, Inbred BALB C, Hybridomas, B-cell lymphoma, comparative, Antibodies, Monoclonal, syndecan-1, Radioimmunotherapy, Flow Cytometry, monoclonal antibody, dog, oncology, Female, Lymphoma, Large B-Cell, Diffuse, Epitope Mapping, diffuse large
Abstract

International audience; We isolated 11 antibodies specific for canine CD138 (cCD138) to validate the interest of CD138 antigen targeting in dogs with spontaneous mammary carcinoma. The affinity of the monoclonal antibodies in the nanomolar range is suitable for immunohistochemistry and nuclear medicine applications. Four distinct epitopes were recognized on cCD138 by this panel of antibodies. CD138 expression in canine healthy tissues is comparable to that reported in humans. CD138 is frequently expressed in canine mammary carcinomas corresponding to the human triple negative breast cancer subtype, with cytoplasmic and membranous expression. In canine diffuse large B-cell lymphoma, CD138 expression is associated with the 'non-germinal center' phenotype corresponding to the most aggressive subtype in humans. This homology of CD138 expression between dogs and humans confirms the relevance of tumour-bearing dogs as spontaneous models for nuclear medicine applications, especially for the evaluation of new tumour targeting strategies for diagnosis by phenotypic imaging and radio-immunotherapy.

Published
2016

9. Additional file 2: Table S2. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Subjects
body regions
Abstract

Significant associations between IGF1R expression and clinicopathological features of 47 luminal canine mammary carcinomas. IGF1R score 0–1+ is considered as the reference for each parameter. IGF1R Insulin-like Growth Factor type 1 Receptor. LVI: Lymphovascular Invasion. OR: Odd Ratio. 95 % CI: 95 % Confidence Interval. (DOC 30 kb)

Published
2015
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10. Additional file 1: Table S1. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Abstract

Primary antibodies and immunohistochemical protocols (Benchmark XT Ventana, Roche Diagnostics). All dilutions were performed using a commercially available diluent (Ventana Medical Systems). aUltraview and bOptiview Universal DAB detection kit: multimer-technology based detection system. cIView Universal DAB detection kit: biotin streptavidin system. ERα: Estrogen Receptor alpha, PR: Progesterone Receptor, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like growth factor type 1 receptor. CC1: Cell Conditioning 1. (DOC 33 kb)

Published
2015
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11. Additional file 1: Table S1. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Abstract

Primary antibodies and immunohistochemical protocols (Benchmark XT Ventana, Roche Diagnostics). All dilutions were performed using a commercially available diluent (Ventana Medical Systems). aUltraview and bOptiview Universal DAB detection kit: multimer-technology based detection system. cIView Universal DAB detection kit: biotin streptavidin system. ERα: Estrogen Receptor alpha, PR: Progesterone Receptor, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like growth factor type 1 receptor. CC1: Cell Conditioning 1. (DOC 33 kb)

Published
2015
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12. Additional file 2: Table S2. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Subjects
body regions
Abstract

Significant associations between IGF1R expression and clinicopathological features of 47 luminal canine mammary carcinomas. IGF1R score 0–1+ is considered as the reference for each parameter. IGF1R Insulin-like Growth Factor type 1 Receptor. LVI: Lymphovascular Invasion. OR: Odd Ratio. 95 % CI: 95 % Confidence Interval. (DOC 30 kb)

Published
2015
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13. Prognostic significance of microvascular density in canine cutaneous melanoma

Author

Wolfe-Taylor Boedec, K, Nguyen, Frédérique, Izembart, A, Guigand, Lydie, Wyers, Monique, Abadie, J, Inconnu, Développement et Pathologie du Tissu Musculaire (DPTM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2007

14. High frequency of spontaneous rhabdomyosarcomas in older mdx mice with X-linked muscular dystrophy

Author

Nguyen, Frédérique, Dorso, L, Belluco, S, Rouger, Karl, Fernandez, Bernard-Yves, Guéreaud, Catherine, Guigand, Lydie, Wyers, Monique, Cherel, Yan, Inconnu, Développement et Pathologie du Tissu Musculaire (DPTM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2007

15. Correlations between Magnetic Resonance Imaging and histopathology in the mdx (X-linked muscular dystrophy) murine model, of Duchenne Muscular Dystrophy

Author

Nguyen, Frédérique, Eliat, PA, Pinot, Marie-Sophie, Franconi, Florence, Lemaire, Laura, de Certaines, J, Cherel, Yan, ProdInra, Migration, Inconnu, Développement et Pathologie du Tissu Musculaire (DPTM), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2006

16. Microvasculature in skeletal muscles of Golden Retriever Muscular Dystrophy dogs

Author

Nguyen, Frédérique, Masson, Mt, Guigand, Lydie, Goubault-Leroux, I, Lavault, Mt, Primaut, R, Wyers, Monique, Cherel, Yan, Inconnu, Développement et Pathologie du Tissu Musculaire (DPTM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2005

17. Les lésions musculaires des modèles animaux de la dystrophie musculaire de Duchenne : évaluation comparée des lésions du modèle murin mdx (X-linked muscular dystrophy) par histopathologie et analyse de texture en IRM : étude de la vascularisation capillaire du muscle canin GRMD (Golden Retriever Muscular Dystrophy)

Author

Nguyen, Frédérique and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], IMAGERIE PAR RÉSONANCE MAGNÉTIQUE, these
Abstract

La dystrophie musculaire de Duchenne (DMD) est une dystrophie musculaire fatale de l'enfant, due à l'absence de dystrophine, protéine du cytosquelette des myofibres. Dans le modèle murin mdx de la DMD, les lésions musculaires d'anisocytose, conversion oxydative des fibres, nécrose et régénération peuvent être quantifiées par analyse de texture en IRM, méthode non invasive proposée pour le suivi d'essais thérapeutiques entrepris dans ce modèle. Dans le modèle canin GRMD, la forme néonatale fulminante est un modèle des lésions précoces de dystrophinopathie, et la forme classique observée à partir de l'âge de deux mois un excellent modèle lésionnel de la DMD. Le réseau capillaire du muscle GRMD est quantitativement peu modifié par rapport aux témoins. La structure des capillaires est modifiée par duplication de la membrane basale qui, avec la fibrose endomysiale précoce, représente un obstacle physique à la diffusion d'un produit thérapeutique génique ou cellulaire.

Published
2005

18. Correlations between Magnetic Resonance Imaging texture features at 7T and histopathology in mdx mice muscles

Author

Eliat, PA, Nguyen, Frédérique, Pinot, Marie-Sophie, Franconi, Florence, Lemaire, Laura, De Certaines, JD, Cherel, Yan, ProdInra, Migration, Inconnu, Développement et Pathologie du Tissu Musculaire (DPTM), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2005

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