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All-inorganic perovskite nanocrystals (NCs) have attractive potential for applications in display and lighting fields due to their special optoelectronic properties. However, they still suffer from poor water and thermal stability. In this work, green CsPbBr3-alginic acid (CsPbBr3-AA) perovskite composites were synthesized by an in situ hot-injection process which showed a high photoluminescence quantum yield (PLQY) of 86.43% and improved moisture and thermal stability. Finally, white light-emitting diodes (WLEDs) were fabricated by combining the green CsPbBr3-AA perovskite composites with red K2SiF6:Mn4+ phosphors and blue InGaN LED chips. The WLEDs show a relatively high luminous efficacy of 36.4 lm/W and a wide color gamut (124% of the National Television System Committee). These results indicate that the green CsPbBr3-AA perovskite composites have great potential applications in backlight displays.

OBJECTIVE This study aimed to investigate reversal of vertebral wedging and to evaluate the contribution of vertebral remodeling to correction maintenance in patients with adolescent Scheuermann’s kyphosis (SK) after posterior-only instrumented correction. METHODS A retrospective cohort study of patients with SK was performed. In total, 45 SK patients aged 10–20 years at surgery were included. All patients received at least 24 months of follow-up and had Risser sign greater than grade 4 at latest follow-up. Patients with Risser grade 3 or less at surgery were assigned to the low-Risser group, whereas those with Risser grade 4 or 5 were assigned to the high-Risser group. Radiographic data and patient-reported outcomes were collected preoperatively, immediately postoperatively, and at latest follow-up and compared between the two groups. RESULTS Remarkable postoperative correction of global kyphosis was observed, with similar correction rates between the two groups (p = 0.380). However, correction loss was slightly but significantly less in the low-Risser group during follow-up (p < 0.001). The ratio between anterior vertebral body height (AVBH) and posterior vertebral body height (PVBH) of deformed vertebrae notably increased in SK patients from postoperation to latest follow-up (p < 0.05). Loss of correction of global kyphosis was significantly and negatively correlated with increased AVBH/PVBH ratio. Compared with the high-Risser group, the low-Risser group had significantly greater increase in AVBH/PVBH ratio during follow-up (p < 0.05). The two groups had similar preoperative and postoperative Scoliosis Research Society–22 questionnaire scores for all domains. CONCLUSIONS Obvious reversal in wedge deformation of vertebrae was observed in adolescent SK patients. Patients with substantial growth potential had greater vertebral remodeling and less correction loss. Structural remodeling of vertebral bodies has a positive effect and protects against correction loss. These results could be help guide treatment decision-making.

Robust point set registration is a challenging problem, especially in the cases of noise, outliers, and partial overlapping. Previous methods generally formulate their objective functions based on the mean-square error (MSE) loss and, hence, are only able to register point sets under predefined constraints (e.g., with Gaussian noise). This article proposes a novel objective function based on a bidirectional kernel mean ${p}$ -power error (KMPE) loss, to jointly deal with the above nonideal situations. KMPE is a nonsecond-order similarity measure in kernel space and shows a strong robustness against various noise and outliers. Moreover, a bidirectional measure is applied to judge the registration, which can avoid the ill-posed problem when a lot of points converges to the same point. In particular, we develop two effective optimization methods to deal with the point set registrations with the similarity and the affine transformations, respectively. The experimental results demonstrate the effectiveness of our methods.

Study design A retrospective case series. Objective To investigate whether unmatched rod contouring at the proximal end predisposed to the occurrence of proximal junctional kyphosis (PJK) in early-onset scoliosis (EOS) patients after traditional growing rods (TGR) treatment. Summary of background data TGR treatment has become a mainstay of treatment for EOS patients. PJK is one of the most common alignment-related complications. Methods A consecutive series of EOS patients who had undergone TGR treatment were retrospectively reviewed. They were divided into PJK and non-PJK groups according to the occurrence of PJK or not. Demographic data, surgical strategies, and radiographic parameters were recorded and compared between groups. Proximal junctional angle (PJA) was defined as the angle between the caudal endplate of the UIV and the cephalad endplate of the second supradjacent vertebra above the UIV, while proximal rod contouring angle (PRCA) was defined as the angle of proximal rod contouring, which was represented by the angle between the cephalad endplate of the UIV and the caudal endplate of the second vertebra caudal to the UIV. Unmatched proximal rod contouring was regarded if the postoperative PRCA-PJA difference was greater than 5°. Results This study finally included 73 patients. The mean age at the index surgery was 6.5 ± 2.2 years (range, 2–10 years). Mean follow-up lasted 5.0 ± 1.7 years (range, 2–9 years). They received mean 4.6 ± 1.6 lengthening procedures. There were 13 patients who were observed with PJK (18%). In comparison with the non-PJK group, the PJK group showed a larger preoperative major curve (82 ± 21° vs 70 ± 17°, P = 0.041) and global kyphosis (57 ± 6° vs. 44 ± 15°, P = 0.044). In addition, the PJK group had significantly larger postoperative PJA (10 ± 3 vs. 5 ± 3, PP = 0.031). The proportion of patients with unmatched proximal rod contouring in PJK group was significantly higher than that in the non-PJK group (69% vs. 25%). Multiple logistic regression showed that preoperative GK>50°, postoperative PJA>10 and postoperative unmatched proximal rod contouring were the risk factors in predicting PJK after TGR treatment. Conclusion Approximately 18% EOS patients experienced PJK after TGR treatment. Unmatched proximal rod contouring may be an independent risk factor of PJK occurrence, in addition to greater preoperative GK and larger postoperative PJA. Level of evidence 3.

Study Design: A retrospective study. Objectives: To investigate the incidence, management and outcome of delayed deep surgical site infection (SSI) after the spinal deformity surgery. Methods: This study reviewed 5044 consecutive patients who underwent spinal deformity corrective surgery and had been followed over 2 years. Delayed deep SSI were defined as infection involving fascia and muscle and occurring >3 months after the initial procedure. An attempt to retain the implant were initially made for all patients. If the infection failed to be eradicated, the implant removal should be put off until solid fusion was confirmed, usually more than 2 years after the initial surgery. Radiographic data at latest follow-up were compared versus that before implant removal. Results: With an average follow-up of 5.3 years, 56 (1.1%) patients were diagnosed as delayed deep SSI. Seven (12.5%) patients successfully retained instrumentation and there were no signs of recurrence during follow-up (average 3.4 years). The remaining patients, because of persistent or recurrent infection, underwent implant removal 2 years or beyond after the primary surgery, and solid fusion was detected in any case. However, at a minimum 1-year follow-up (average 3.9 years), an average loss of 9° in the thoracic curve and 8° in the thoracolumbar/lumbar curves was still observed. Conclusions: Delayed deep SSI was rare after spinal deformity surgery. To eradicate infection, complete removal of implant may be required in the majority of delayed SSI. Surgeons must be aware of high likelihood of deformity progression after implant removal, despite radiographic solid fusion.

STUDY DESIGN A retrospective study. OBJECTIVE The aim of this study was to investigate the ability of Global Alignment and Proportion (GAP) score to predict the occurrence of adjacent segment degeneration (ASD) after fusion surgery for lumbar degenerative diseases. SUMMARY OF BACKGROUND DATA The recently developed GAP score was applied to predict postoperative complications for adult spinal deformity, as well as to facilitate future outcome-based research on optimal treatment for various spinal conditions. However, it remains unclear whether reconstruction of alignment according to GAP score can reduce the ASD rates. METHODS This study retrospectively reviewed 126 consecutive patients who had undergone lumbar fusion and had been followed over 2 years. Pre- and postoperative radiographs and MRI were analyzed for ASD. GAP scores were calculated based on the early postoperative spinopelvic parameters. Cochran-Armitage test of trend was performed to investigate the association between GAP score and the occurrence of ASD. Receiver-operating characteristic curves were used to analyze the predictive accuracy of the GAP score for ASD. RESULTS Radiographical ASD (R-ASD) and symptomatic ASD (S-ASD) were diagnosed in 44 (34.9%) patients and in 13 (10.3%) patients, respectively. The patients with a proportioned spinopelvic state according to the GAP score had significantly lower rates of ASD (R-ASD and S-ASD) or S-ASD than those with a moderately or severely disproportioned spinopelvic state. The area under curve for the GAP score predicting ASD and S-ASD was 0.691 (95% confidence interval [CI]: 0.596∼0.785, P

Taking “divide-and-conquer” as a basic idea, cooperative coevolution (CC) has shown a promising prospect in large scale global optimization. However, its high requirement on the decomposition accuracy can hardly be satisfied in practice. Directing against this issue, this study proposes a bi-hierarchical cooperative coevolution (BHCC), which can tolerate a certain degree of decomposition error. Besides the cooperation among sub-problems as in the conventional CC, BHCC introduces a kind of cooperation between sub-problems and the overall problem. By systematically exploiting the excellent sub-solutions obtained during the sub-space optimization process, it initializes the population for the optimization process on the overall problem and thus can conduct search in promising regions of the whole solution space. The newly acquired complete solutions are in turn employed to update the context vector and the population of each sub-problem, where the context vector is used for sub-solution evaluation. Consequently, the search direction misdirected by an improper decomposition can be corrected to a great extent. To keep the balance between the two types of optimization processes, an adaptive triggering mechanism for the overall optimization process is specially designed for BHCC. Experimental results on two widely-used benchmark suites verify the effectiveness of the new strategies in BHCC and also indicate that BHCC is more robust than existing CCs and can achieve competitive performance compared with several state-of-the-art algorithms.

With the development of RGBD sensors, the high-quality color point cloud can be obtained expediently. In this paper, we propose a novel registration method for 3D color point clouds from different views, which is a critical issue in many applications. Different from traditional feature-based methods, we design a hybrid feature representation with color moments of the point, which could be applied naturally for any color point cloud. And these features are extracted from point clouds based on the supervoxel segmentation. By jointly conducting these features for similarity measure, a weight parameter is dynamically adapted between the color and the spatial information. The registration algorithm is under a classic iterative framework for building the correspondence and estimating transformation parameters. In addition, we provide a mutual correspondence matching condition with hybrid features to build some more robust relationships for estimating transformation parameters. Experimental results demonstrate that our method can effectively reduce the number of point data for registration and achieve good matching results even in a poor initial condition.

All-inorganic halide perovskite nanomaterials have a high application potential in the field of display and lighting because of unique photoelectric properties. However, these materials suffer from problems related to poor water and thermal stabilities. In this study, green Eu3+-doped CsPbBr3/Cs4PbBr6 perovskite composites that were synthesized by a saturated recrystallization method at room temperature showed an enhanced photoluminescence quantum yield of 87% and superior water and thermal stabilities to that of undoped perovskites. Finally, green Eu3+-doped CsPbBr3/Cs4PbBr6 perovskite composites were fabricated into white light-emitting diodes (WLEDs) with a wide color gamut (124% of the National Television System Committee standard) and a high efficiency of 43.06 lm/W.

Study Design: A retrospective studyObjectives: To investigate the impact of radiological and surgical factors as well as proximal rod contouring angle (PRCA) on the development of proximal junctional kyphosis (PJK) in early-onset scoliosis(EOS) patients after growing rod (GR) treatment.Methods: We reviewed a consecutive series of EOS patients who had undergone growing rod (GR) treatment between 2009 and 2018 (minimum follow-up of 2 years) at a single institution. Patients were divided into PJK and non-PJK groups according to the occurrence of PJK or not during the follow-up periods. The demographic data, surgical strategies, and radiographic parameters were recorded and compared between the PJK and non-PJK groups. PJK was defined as a PJA＞10° at the last follow-up. PRCA was defined as the angle between the cephalad endplate of the UIV and the lower endplate of the second vertebra caudal to UIV and the PJA-PRCA was defined as the difference between the values of PJA and PRCA. Logistic regression was also performed to identify the risk factors for the occurrence of PJK.Results: This study finally included 95 patients. The mean age at the index surgery was 6.5±2.2 years. Mean follow-up lasted 4.4±1.9 years. Lengthening procedures averaged 4.0 ± 1.8 times. There were 20 patients who were observed with PJK (the incidence, 21.1%). In comparison with the non-PJK group, the PJK group showed a larger preoperative coronal cobb angle (81.8±20.6° vs 70.4±12.4°, P=0.041) and global kyphosis (GK) (56.0±15.3° vs. 45.9±12.9°, P=0.044), as well as a larger GK correction (40.4%±10.0% vs. 30.0%±14.2%, P=0.035). In addition, the PJK group had significantly larger postoperative PJA (10.8±3.1 vs. 5.3±3.1, P＜0.001) and greater postoperative PJA-PRCA (5.3±3.0 vs. 3.66±2.9, P=0.031). The proportion of patients with a value of PJA-PRCA greater than 5° in PJK group was significantly higher than that in the non-PJK group. Multiple logistic regression showed that preoperative GK＞50°, postoperative PJA＞10 and postoperative PJA-PRCA＞5° were the risk factors in predicting PJK after GR treatment.Conclusions: More than one-fifth EOS patients experienced PJK after GR treatment. Besides greater preoperative GK and larger postoperative PJA, PJA-PRCA mismatch may be an independent risk factor of PJK occurrence.

OBJECTIVE The objective of this study was to investigate the incidence and risk factors of coronal imbalance (CI) in patients with early-onset scoliosis (EOS) who underwent growing rod (GR) treatment. METHODS A consecutive series of 61 patients with EOS (25 boys and 36 girls, mean age 5.8 ± 1.7 years) who underwent GR treatment was retrospectively reviewed. Postoperative CI was defined as postoperative C7 translation on either side ≥ 20 mm. Patients were divided into an imbalanced and a balanced group. Coronal patterns were classified into three types: type A (C7 translation < 20 mm), type B (C7 translation ≥ 20 mm with C7 plumb line [C7PL] shifted to the concave side of the curve), and type C (C7 translation ≥ 20 mm and a C7PL shifted to the convex side of the curve). RESULTS Each patient had an average of 5.3 ± 1.0 lengthening procedures and was followed for an average of 6.2 ± 1.3 years. Eleven patients (18%) were diagnosed with CI at the latest distraction, 5 of whom graduated from GRs and underwent definitive fusion. However, these patients continued to present with CI at the last follow-up evaluation. The proportion of preoperative type C pattern (54.5% vs 16.0%, p = 0.018), immediate postoperative apical vertebral translation (30.4 ± 13.5 mm vs 21.2 ± 11.7 mm, p = 0.025), lowest instrumented vertebra tilt (11.4° ± 8.2° vs 7.3° ± 3.3°, p = 0.008), and spanned obliquity angle (SOA) (9.7° ± 10.5° vs 4.1° ± 4.5°, p = 0.006) values in the imbalanced group were significantly higher than in the balanced group. Multiple logistic regression demonstrated that a preoperative type C pattern and immediate postoperative SOA > 11° were independent risk factors for postoperative CI. CONCLUSIONS The incidence of CI in patients with EOS who underwent GR treatment was 18%. This complication could only be slightly improved after definitive spinal fusion because of the autofusion phenomenon. A preoperative type C pattern and immediate postoperative SOA > 11° were found to be the risk factors for CI occurrence at the latest follow-up.

It has been shown that cooperative coevolution (CC) can effectively deal with large scale optimization problems (LSOPs) through a ‘divide-and-conquer’ strategy. However, its performance is severely restricted by the current context-vector-based sub-solution evaluation method, since this method needs to invoke the original high dimensional simulation model when evaluating each sub-solution, thus requiring many computation resources. To alleviate this issue, this study proposes a novel surrogate model assisted cooperative coevolution (SACC) framework. SACC constructs a surrogate model for each sub-problem and employs it to evaluate corresponding sub-solutions. The original simulation model is only adopted to reevaluate a small number of promising sub-solutions selected by surrogate models, and these really evaluated sub-solutions will in turn be employed to update surrogate models. By this means, the computation cost could be greatly reduced without significantly sacrificing evaluation quality. By taking the radial basis function (RBF) and the success-history based adaptive differential evolution (SHADE) as surrogate model and optimizer, respectively, this study further designs a concrete SACC algorithm named RBF-SHADE-SACC. RBF and SHADE have only been proved to be effective on small and medium scale problems. This study scales them up to LSOPs under the SACC framework, where they are tailored to a certain extent for adapting to the characteristics of LSOPs and SACC. Empirical studies on IEEE CEC 2010 benchmark functions demonstrate that SACC can significantly enhance the sub-solution evaluation efficiency, and even with much fewer computation resources, RBF-SHADE-SACC can find much better solutions than traditional CC algorithms.

Objectives To compare the differences in sagittal spinopelvic parameters between patients receiving monosegmental or multisegmental lumbar fusion and to assess the impact of fusion length on sitting balance. Methods The current study recruited 41 patients who had undergone lumbar fusion, consisting of 18 in the monosegmental group and 23 in the multisegmental group. And the control group included 50 lumbar degenerative patients who had no previous spinal fusion surgery. Spinopelvic parameters of patients were assessed: sagittal vertical axis, pelvic tilt, sacral slope, pelvic incidence, thoracic kyphosis, lumbar lordosis, and proximal femur angles. Results We observed significant differences in sitting TK (P = 0.031), LL (P = 0.012), PT (P = 0.009) and SVA (P = 0.009) among the three groups. When transitioning from standing to sitting, the multisegmental group had the least change in SVA (P = 0.016), PT (P = 0.043), and LL (P = 0.009), with a compensatory increase in TK (P = 0.021). Moderate to strong correlations were found between the change in the LL and those in the SVA (r = −0.548, P = 0.001), PT (r = −0.600, P = 0.001), and SS (r = 0.623, P = 0.001). Conclusion Multisegmental lumbar fusion significantly limits the lumbar mobility and affects the ability to compensate postural changes. Reducing the fusion segments as much as possible is of particular value in preserving lumbar mobility and maintaining the compensatory mechanism of spinopelvis.

Divide-and-conquer-based (DC-based) evolutionary algorithms (EAs) have achieved notable success in dealing with large-scale optimization problems (LSOPs). However, the appealing performance of this type of algorithms generally requires a high-precision decomposition of the optimization problem, which is still a challenging task for existing decomposition methods. This study attempts to address the above issue from a different perspective and proposes an eigenspace divide-and-conquer (EDC) approach. Different from existing DC-based algorithms that perform decomposition and optimization in the original solution space, EDC first establishes an eigenspace by conducting singular value decomposition on a set of high-quality solutions selected from recent generations. Then it transforms the optimization problem into the eigenspace, and thus significantly weakens the dependencies among the corresponding eigenvariables. Accordingly, these eigenvariables can be efficiently grouped by a simple random decomposition strategy and each of the resulting subproblems can be addressed more easily by a traditional EA. To verify the efficiency of EDC, comprehensive experimental studies were conducted on two sets of benchmark functions. Experimental results indicate that EDC is robust to its parameters and has good scalability to the problem dimension. The comparison with several state-of-the-art algorithms further confirms that EDC is pretty competitive and performs better on complicated LSOPs.

In this paper, we present a novel particle swarm optimization (PSO) variant named scatter learning PSO algorithm (SLPSOA) for solving multimodal problems. SLPSOA takes full account of the distribution information of exemplars while following the basic framework of PSO. It constructs an exemplar pool (EP) which is composed of a certain number of relatively high-quality solutions scattering in the solution space, and allows each particle to select a solution from EP as the exemplar using the roulette wheel rule, with the aim of leading the particles to promising solution regions. In addition, SLPSOA employs Solis and Wets? algorithm as a local searcher to enhance its fine search ability in the newfound solution regions. SLPSOA was tested on 16 benchmark functions, and compared with five existing typical PSO algorithms. Computational results demonstrate that it can manage to prevent premature convergence and produce competitive solutions.