1. Deletion of IER3IP1 in mice
- Author
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Men, Lili, sun, Juan, qiao, Lu, Xie, Xinyue, Zhao, Tong, Ren, Decheng, and Du, Jianling
- Abstract
Targeting strategy 1. For conditional knockout, the loxP fragments are usually inserted into the introns downstream of the ATG-containing-exon and removal of the flanked exon(s) will result in frame-shift for protein translation. 2. This design is to conditionally knockout the exon 2 and exon3 by Cre-loxP system. The intron 1 is big and insertion of 5’ loxP element will not interfere ier3ip1 mRNA splicing. 3’loxP will be inserted into intergenic region downstream of ier3ip1 and upstream of the promoter-assoicated elements of Hdhd2.
- Published
- 2022
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