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To assess men's preferences for healthcare provider from whom they would obtain hormonal male contraceptive (HMC) methods.We asked participants from 3 clinical trials of investigational HMC methods-an oral pill (11β-Methyl-19-nortestosterone-17β-dodecylcarbonate, 11β-MNTDC), intramuscular or subcutaneous injection (Dimethandrolone undecanoate), and transdermal gel (Nestorone and testosterone)-to rank their top 3 preferred HMC providers from a list including: men's health doctor (urologist/andrologist), hormonal doctor (endocrinologist), reproductive health doctor (OB/GYN), family planning clinician (community health worker, midwife, nurse practitioner), regular doctor (family medicine/internal medicine), and community pharmacist. We examined preferences based on their rankings and conducted bivariate analyses. Collapsing the various specialists (men's health doctor, hormonal doctor, reproductive health doctor, and family planning clinician) into a single provider type, we examined participant demographics against provider preference (regular doctor, pharmacist, or specialist).Participants across the 3 trials (n = 124) ranked their regular doctor (44%) and community pharmacist (18%) as their most preferred HMC provider; these preferences did not differ significantly by trial and drug formulation. Specialists in family planning (13%), men's health (12%), reproductive health (10%), and hormones (4%) were least frequently ranked as their preferred provider. Older and higher educated participants more often preferred specialists over regular doctors and pharmacists (p = 0.02 and p = 0.01).Despite receiving contraceptive steroid hormones and care from endocrinologists and family planning specialists in a clinical trial, participants would prefer to obtain contraception from their regular doctor.As most men expect to obtain hormonal male contraceptives from their regular doctor when commercially available, primary care physicians should become familiar with HMCs and be prepared to provide counseling and options accordingly.

Laura Caruso,1 Alessia Castellino,2 Daniela Dessì,3 Leonardo Flenghi,4 Antonio Giordano,5 Adalberto Ibatici,6 Cesare Massone,7 Alessandro Pileri,8 Ilaria Proietti,9 Livio Pupo,10 Pietro Quaglino,11 Serena Rupoli,12 Pier Luigi Zinzani13,14 1Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliero Universitaria Policlinico G. Rodolico - San Marco Di Catania, Catania, Italy; 2Department of Hematology, Santa Croce E Carle Hospital, Cuneo, Italy; 3Department of Hematology, Businco Hospital Arnas AOB, Cagliari, Italy; 4Hematology and Bone Marrow Transplantation Unit, Santa Maria Della Misericordia Hospital, Perugia, Italy; 5Department of Hematology, Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, Rome, Italy; 6Hematology and Transplant Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy; 7Dermatology Unit, Ospedali Galliera, Genova, Italy; 8Dermatology Unit, IRCCS S. Orsola-Malpighi Polyclinic, Bologna, Italy. Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy; 9Dermatology Unit”Daniele Innocenzi”, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Terracina, Italy; 10UOC Lymphoproliferative Diseases, Fondazione PTV Policlinico Tor Vergata, Rome, Italy; 11Dermatologic Clinic, Department of Medical Sciences University of Turin Medical School, Turin, Italy; 12Clinic of Hematology, Ospedali Riuniti Ancona, Ancona, Italy; 13IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Serà gnoli”, Bologna, Italy; 14Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna, Bologna, ItalyCorrespondence: Pier Luigi Zinzani, IRCCS University Hospital of Bologna, Serà gnoli Institute of Hematology, and Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, via Massarenti 9, Bologna, 40138, Italy, Tel +39 051 2144042, Fax +39 051 2144037, Email pierluigi.zinzani@unibo.itAbstract: Mycosis fungoides and Sèzary syndrome are the most studied subtypes common cutaneous T-cell lymphomas. The current treatment objective is to improve the clinical manifestations of the disease in the affected areas, to relieve symptoms and to halt disease progression. Patients with early-stage mycosis fungoides are usually managed with skin-directed therapies, whereas patients with resistant or advanced-stage mycosis fungoides or Sèzary syndrome often require systemic drugs. Over the last decade, new drugs have been developed, increasing the breadth of treatment options for cutaneous T-cell lymphomas patients. Mogamulizumab is a first-in-class defucosylated humanized IgG1 κ monoclonal antibody, which exerts its anti-tumour action by selectively binding to C-C chemokine receptor 4 and increasing antibody-dependent cellular cytotoxicity activity against malignant T-cells. Several clinical trials showed that mogamulizumab is able to effectively control the cutaneous T-cell lymphomas in each site (skin, blood, lymph nodes and viscera), improving patients’ symptoms, function and overall quality of life with a manageable safety profile. In this report, we discuss 12 cases of patients with mycosis fungoides or Sèzary syndrome successfully treated with mogamulizumab in real-life clinical practice in Italy.Keywords: cutaneous T- cell lymphoma, mycosis fungoides, Sèzary syndrome, mogamulizumab

Wildfires have increased in the last years and, when caused by intentional illegal burnings, are frequently run out of control. Wildfire has been pointed out as an important source of polycyclic aromatic hydrocarbons (PAHs) and trace elements (TEs) - such as, As, Ni, and Pb - to environmental compartments, and thus may pose a risk to human health and to the ecosystem. In 2020, the Brazilian biome, Pantanal, faced the largest losses by wildfires in the last 22 years. Ashes from the topsoil layer in Pantanal were collected after these wildfires at 20 sites divided into the sediment, forest, PF, PS, and degraded sites. Toxicity and associated risks for human health were also evaluated. The areas highly impacted by wildfires and by artisanal gold mining activities showed higher concentrations for TEs and PAHs than the protected areas. Pb varied from 8 ± 4 to 224 ± 81 mg kgThe online version contains supplementary material available at 10.1007/s11869-022-01248-2.

Aims: To formulate, implement, and validate a user-independent release of CLEAN for Fourier-based image reconstruction of hard X-rays flaring sources. Methods: CLEAN is an iterative deconvolution method for radio and hard X-ray solar imaging. In a specific step of its pipeline, CLEAN requires the convolution between an idealized version of the instrumental Point Spread Function (PSF), and a map collecting point sources located at positions on the solar disk from where most of the flaring radiation is emitted. This convolution step has highly heuristic motivations and the shape of the idealized PSF, which depends on the user's choice, impacts the shape of the overall reconstruction. Here we propose the use of an interpolation/extrapolation process to avoid this user-dependent step, and to realize a completely unbiased version of CLEAN. Results: Applications to observations recorded by the Spectrometer/Telescope for Imaging X-rays (STIX) on-board Solar Orbiter show that this unbiased release of CLEAN outperforms the standard version of the algorithm in terms of both automation and reconstruction reliability, with reconstructions whose accuracy is in line with the one offered by other imaging methods developed in the STIX framework. Conclusions: This unbiased version of CLEAN proposes a feasible solution to a well-known open issue concerning CLEAN, i.e., its low degree of automation. Further, this study provided the first application of an interpolation/extrapolation approach to image reconstruction from STIX experimental visibilities.

FOXSI is a direct-imaging, hard X-ray (HXR) telescope optimized for solar flare observations. It detects hot plasma and energetic electrons in and near energy release sites in the solar corona via bremsstrahlung emission, measuring both spatial structure and particle energy distributions. It provides two orders of magnitude faster imaging spectroscopy than previously available, probing physically relevant timescales (, White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 14 pages, 4 figures, 1 table

The solar corona is the outer layer of the Sun atmosphere. The brightness of the solar corona is a million times lower than the solar disk. The Earth’s sky brightness itself is higher enough to cover the coronal signal during ground-based observations. For this reason, the study of sky characteristics plays a fundamental role in observing the solar corona. To date, the only place with the sky characteristics that allow continuous coronagraphic measurements from Earth is at the MLO (Mauna Loa Observatory; Hawaii, ≈ 3400 m a.s.l.). This paper shows the results obtained as part of the “Extreme Solar Coronagraphy Antarctic Program Experiment” (ESCAPE) at Concordia Base, Antarctica (Dome C plateau-coord: 75 06S; 123 20E-≈ 3300 m above sea level) during the 37th campaign and give a summary of all the sky-brightness measurements obtained from this site (campaign 34th and 35th). Dome C is confirmed to be a coronagraphic site with a sky brightness value of about 1×10^−6 B⊙. For the first time, it was also possible to detect a coronal signal and to compare it with what was measured by the COronal Solar Magnetism Observatory (COSMO) K-coronagraph (K-Cor) at the MLO. All these results were obtained by using a micropolarizer camera mounted within a coronagraph designed for Antarctic environments.

The association of roots with mycorrhizal fungi increases the establishment success of forest species. Cordilleran cypress naturally forms associations with arbuscular mycorrhizae (AM). In general, the use of fertigation and artificial growth methods causes a decrease in mycorrhization, which could lead to a decrease in seedling performance in the field. The objectives of this study were: to determine whether AM colonization occurs in a nursery; to evaluate the influence of differing availability of phosphorus and substrate water status on the level of mycorrhizal colonization during plant growth; and to analyze the abundance of mycorrhization and its relationship with post-planting survival. The trial treatments were only applied during plant growth and consisted of a combination of three phosphorus concentration levels (1, 10 and 100 mg L-1) and two substrate water statuses (20 and 80 % of the container capacity (Cc)). The percentage of mycorrhization (% AM) was evaluated in plants grown in a nursery, in a sterilized substrate in the field, as was its survival in the field. Among the most relevant results, 24 % AM was found in the nursery while this value increased in the field (93 %), indicating that the mycorrhizal colonization process occurs during plant growth, even though it is partially inhibited by phosphorus and water management. It was also observed that the % MA increased once the plant was taken to the field independently of the % MA of the seedling in the nursery., La asociación de raíces con hongos micorrícicos aumenta el prendimiento en la implantación de especies forestales. El ciprés de la cordillera forma naturalmente micorrizas del tipo arbusculares (MA). En general, el uso de fertirriego y medios de crecimiento artificiales provoca una disminución de la micorrización, lo que podría repercutir en una disminución del desempeño a campo del plantín. Los objetivos de este estudio fueron: estudiar si se produce colonización de MA en vivero; evaluar la influencia de distintas disponibilidades de fósforo y estados hídricos del sustrato en el nivel de colonización micorrícica durante la viverización; analizar la abundancia de la micorrización y su relación con la supervivencia post plantación. Los tratamientos de los ensayos solo se aplicaron durante la viverización, y consistieron en la combinación de tres niveles de concentración de fósforo (1, 10 y 100 mg L-1) y dos estados hídricos del sustrato (20 y 80 % de la capacidad de contenedor (Cc). Se evaluó el porcentaje de micorrización (% MA) en plantas cultivadas en vivero, en sustrato esterilizado y en campo, como así también la supervivencia en campo. Entre los resultados más relevantes se encontró un % MA en vivero del 24 % y un aumento de este valor en campo (93 %), mostrando que el proceso de colonización micorrícica se produce durante la viverización, a pesar de que la misma se encuentre inhibida parcialmente por el manejo del fósforo y del agua. También se observó que el % MA aumentó una vez que la planta fue llevada a campo independientemente del % MA que el plantín tenía en el vivero.

Considering that the current water crisis is largely a governance crisis, improving water governance will help address current and future water challenges. Water governance is defined as the range of political, institutional and administrative rules, practices and processes through which decisions are taken and implemented, stakeholders can articulate their interests and have their concerns considered, and decision-makers are held accountable for water management. The Water Governance Principles proposed by the OECD contribute to the creation of tangible public policies oriented towards effectiveness, efficiency, reliability and participation. The aim of this research is to apply the OECD Water Governance Indicator Framework at a local level and to identify gaps and challenges for water governance in the General Pueyrredon Municipality (GPM), Buenos Aires Province (BAP), Argentina. This framework was used as a diagnostic tool to assess water governance policy frameworks (what), institutions (who) and instruments (how). In general terms, there is a robust legal framework, there are enforcement institutions regarding water management and there is a good connection with them. However, the main challenges identified were in the ‘how’ since most of the instruments are partly or not implemented.

The Spectrometer/Telescope for Imaging X-rays (STIX) on-board Solar Orbiter measures the X-ray photons emitted by thermal and non-thermal electrons via bremsstrahlung mechanisms. STIX modulates the incident radiation by means of 30 sub-collimators that provide information on the complex values of specific Fourier components of the flaring X-ray source. This talk will illustrate this data formation process and explain how this model can be exploited to formulate image reconstruction methods including constrained maximum entropy, multi-scale CLEAN, feature augmentation, and Particle Swarm Optimization for parametric imaging. These methods will be applied against several experimental STIX observations and the reliability of the reconstructed morphologies will be validated by comparison with EUV maps recorded by the Atmospheric Imaging Assembly (AIA) on-board the Solar Dynamics Observatory.

The fundamental science objective behind solar X-ray imaging spectroscopy is to gain information on the electrons accelerated by magnetic reconnection and on the temperature of the correspondingly heated plasma throughout the whole flaring volume. This talk will prove that the visibility-based technology at the base of the Spectrometer/Telescope for Imaging X-rays (STIX) allows the construction of electron flux and differential emission measure maps that are nicely smoothed along the energy and temperature directions, respectively. Using this approach, we will perform a spatially resolved analysis of the electron flux spectra associated with hard X-ray emissions measured by STIX and discuss the spatially resolved consistency of such emissions with a thermal distribution of the electrons in the flaring source.

In our view, machine/deep learning for flare forecasting is still more a promise for future scenarios than the reference framework for current operational facilities. This delay from the application of AI methods in research settings to their use for real-time forecasting is probably due to the persistence of technical open issues involving, by instance, the optimization strategy of the training phase, the quantitative assessment of the prediction performances, the reduction of the computational burden. This talk proposes a video-based deep learning approach to flare forecasting in which the optimization of the network’s parameters is realized by means of a probabilistic score-oriented loss function, the training procedure accounts for the part of the solar cycle progression when the prediction is requested, and the prediction performances are assessed by means of value-weighted skill scores that give greater importance to the values of the prediction than to its quality. The talk will also show the operational potentialities of this approach and discuss how feature selection may reduce the information redundancy, thus increasing the computational efficiency.

Spark's nevus is a particular type of melanocytic nevus, with histology that shows features of both Spitz and Clark nevus. Detailed dermoscopic features in a series of Spark nevi have not been described yet. We performed a monocentric retrospective observational study on 20 lesions of Spark nevus excised from 19 patients (M:F = 10:9; mean age: 37,6 years), reviewed by 5 experts in dermoscopy and 2 dermatopathologists. A histologic review confirmed that Spark nevi were mostly symmetric (80%), well circumscribed (100%), mainly compound (65%) melanocytic lesions with either epithelioid (55%) or spitzoid (45%) cell morphology and bridging of the nests (100%). Spark nevi were more frequently found on the trunk (85%) in patients with a history of sunburns in childhood (84%), with skin phototype III (79%), and with high nevus count (>100 nevi, 7 patients (36%)). On dermoscopy, we observed different general patterns: multicomponent (40%), reticular-globular-homogeneous (15%), globular homogeneous (15%), reticular (15%), reticular-globular (5%), homogeneous (5%), and globular (5%). Spark nevi showed frequently dermoscopic asymmetry (63%), brown color (90%) with areas of central hyperpigmentation (41%) and peripheral hypopigmentation (28%), atypical pigment network (48%), irregular globules (42%), irregular dots (31%), irregular blotches (16%), blue-whitish veil (13%), peripheral island (25%), irregular hyperpigmented areas (12%), and regression (33%). BRAF mutation was present in 7 of the 10 analyzed cases (70%); all these cases presented a history of evolution. In conclusion, Spark nevi occur on the trunk of young adults with high nevus count and history of sunburns; dermoscopic features are protean, often atypical and suspicious of melanoma.

Multi-scale deconvolution is an ill-posed inverse problem in imaging, with applications ranging from microscopy, through medical imaging, to astronomical remote sensing. In the case of high-energy space telescopes, multi-scale deconvolution algorithms need to account for the peculiar property of native measurements, which are sparse samples of the Fourier transform of the incoming radiation. The present paper proposes a multi-scale version of CLEAN, which is the most popular iterative deconvolution method in Fourier space imaging. Using synthetic data generated according to a simulated but realistic source configuration, we show that this multi-scale version of CLEAN performs better than the original one in terms of accuracy, photometry, and regularization. Further, the application to a data set measured by the NASA Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) shows the ability of multi-scale CLEAN to reconstruct rather complex topographies, characteristic of a real flaring event.

In September 2021 on the platform of the Italian Association of Hospital Dermatologists (ADOI; https://www.adoi.it/) a monthly on-line live session of teledermatopathology was started involving collegial discussion among experienced Italian pathologists about challenging melanocytic tumors using the virtual microscope [...].

Aims. To provide a schematic mathematical description of the imaging concept of the Spectrometer/Telescope for Imaging X-rays (STIX) on board Solar Orbiter. The derived model is the fundamental starting point for both the interpretation of STIX data and the description of the data calibration process. Methods. We describe the STIX indirect imaging technique which is based on spatial modulation of the X-ray photon flux by means of tungsten grids. We show that each of 30 STIX imaging sub-collimators measures a complex Fourier component of the flaring X-ray source corresponding to a specific angular frequency. We also provide details about the count distribution model, which describes the relationship between the photon flux and the measured pixel counts. Results. We define the image reconstruction problem for STIX from both visibilities and photon counts. We provide an overview of the algorithms implemented for the solution of the imaging problem, and a comparison of the results obtained with these different methods in the case of the SOL2022-03-31T18 flaring event.

Simple Summary Cutaneous squamous cell carcinoma is one of the most common forms of cancer. Although most cases are cured with surgical excision, a few tumors are associated with a high risk of local or distant relapse; therefore, it is relevant to identify high-risk lesions among all other low-risk CSCCs for the proper diagnostic and therapeutic management. Chemotherapy achieves mostly short-lived responses that do not lead to a curative effect and are associated with severe toxicities. Recently, PD-1 inhibitor cemiplimab was approved by the regulatory authorities for the treatment of advanced cutaneous squamous cell carcinoma; subsequently, the anti-PD-1 agent pembrolizumab received the approval by the FDA only in the same setting. Here, we provide a literature review and clinical recommendations by a panel of experts regarding the diagnosis, treatment, and follow-up of cutaneous squamous cell carcinoma. Abstract Cutaneous squamous cell carcinomas (CSCC) account for about 20% of all keratinocyte carcinomas, which are the most common form of cancer. Heterogeneity of treatments and low mortality are a challenge in obtaining accurate incidence data and consistent registration in cancer registries. Indeed, CSCC mostly presents as an indolent, low-risk lesion, with five-year cure rates greater than 90% after surgical excision, and only few tumors are associated with a high-risk of local or distant relapse; therefore, it is particularly relevant to identify high-risk lesions among all other low-risk CSCCs for the proper diagnostic and therapeutic management. Chemotherapy achieves mostly short-lived responses that do not lead to a curative effect and are associated with severe toxicities. Due to an etiopathogenesis largely relying on chronic UV radiation exposure, CSCC is among the tumors with the highest rate of somatic mutations, which are associated with increased response rates to immunotherapy. Thanks to such strong pre-clinical rationale, clinical trials led to the approval of anti-PD-1 cemiplimab by the FDA (Food and Drug Administration) and EMA (European Medicines Agency), and anti-PD-1 pembrolizumab by the FDA only. Here, we provide a literature review and clinical recommendations by a panel of experts regarding the diagnosis, treatment, and follow-up of CSCC.

This case was presented at the on-line telepathology meeting on the ADOI platform held on October 19th 2022 by Dr Luongo.

Variably scaled kernels and mapped bases constructed via the so-called fake nodes approach are two different strategies to provide adaptive bases for function interpolation. In this paper, we focus on kernel-based interpolation and we present what we call mapped variably scaled kernels, which take advantage of both strategies. We present some theoretical analysis and then we show their efficacy via numerical experiments. Moreover, we test such a new basis for image reconstruction tasks in the framework of hard X-ray astronomical imaging.

Coronal Mass Ejections (CMEs) correspond to dramatic expulsions of plasma and magnetic field from the solar corona into the heliosphere. CMEs are scientifically relevant because they are involved in the physical mechanisms characterizing the active Sun. However, more recently CMEs have attracted attention for their impact on space weather, as they are correlated to geomagnetic storms and may induce the generation of Solar Energetic Particles streams. In this space weather framework, the present paper introduces a physics-driven artificial intelligence (AI) approach to the prediction of CMEs travel time, in which the deterministic drag-based model is exploited to improve the training phase of a cascade of two neural networks fed with both remote sensing and in-situ data. This study shows that the use of physical information in the AI architecture significantly improves both the accuracy and the robustness of the travel time prediction.

This Letter reports the first observational estimate of the heating rate in the slowly expanding solar corona. The analysis exploits the simultaneous remote and local observations of the same coronal plasma volume with the Solar Orbiter/Metis and the Parker Solar Probe instruments, respectively, and relies on the basic solar wind magnetohydrodynamic equations. As expected, energy losses are a minor fraction of the solar wind energy flux, since most of the energy dissipation that feeds the heating and acceleration of the coronal flow occurs much closer to the Sun than the heights probed in the present study, which range from 6.3 to 13.3 solar radii. The energy deposited to the supersonic wind is then used to explain the observed slight residual wind acceleration and to maintain the plasma in a non-adiabatic state. As derived in the Wentzel-Kramers-Brillouin limit, the present energy transfer rate estimates provide a lower limit, which can be very useful in refining the turbulence-based modeling of coronal heating and subsequent solar wind acceleration.

The increase in strength of Steel Fiber Reinforced Concrete (SFRC) depends mainly on factors such as the dosage, aspect ratio and number of hooked ends of the fibers. Previous studies proposed models to estimate the flexural and shear strength of SFRC beams, but the shear behavior of SFRC panels has not been extensively studied. The study includes diagonal tension tests on concrete panels to assess the shear performance of SFRC. The experimental program comprises 19 square concrete panels having 600 mm side and 75 mm thickness, including three nominal dosages of steel fibers (20, 40 and 60 kg/m3) and three different number of hooked ends (1, 1.5 and 2). The study proposes models to predict the shear strength and deformation capacity, stiffness degradation and toughness of SFRC panels with different number of hooked ends when subjected to diagonal tension. The models include four characteristic limit states of diagonal cracking, maximum residual strength, code-based acceptable degradation, and maximum deformation. The authors thank to Vicerrectoría de Investigaciones of UMNG for the financial support of the EXT-INV-3575 project. The authors also would like to thank Research Assistants Juan D. Vargas and Diego Silva at Universidad Militar Nueva Granada (UMNG) for data and figure processing. The authors also thank the companies Cemex-Colombia and Proalco-Bekaert-Colombia for supplying the concrete and steel fibers, respectively. All data that support the findings of this study are available from the corresponding author upon reasonable request. The views expressed in this paper are solely those of the authors and do not necessarily reflects the views of the sponsors.

Aims. We seek to determine to what extent the problem of forward fitting visibilities measured by the Spectrometer/Telescope Imaging X-rays (STIX) on board Solar Orbiter becomes more challenging with respect to the same problem in the case of previous hard X-ray solar imaging missions. In addition, we aim to identify an effective optimization scheme for parametric imaging for STIX. Methods. This paper introduces a global search optimization for forward-fitting STIX visibilities and compares its effectiveness with respect to the standard simplex-based optimization used so far for the analysis of visibilities measured by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). We made this comparison by considering experimental visibilities measured by both RHESSI and STIX, as weel as synthetic visibilities generated by accounting for the STIX signal formation model. Results. We found that among the three global search algorithms for parametric imaging, particle swarm optimization (PSO) exhibits the best performances in terms of both stability and computational effectiveness. This method is as reliable as the simplex method in the case of RHESSI visibilities. However, PSO is significantly more robust when applied to STIX simulated and experimental visibilities. Conclusions. A standard optimization based on local search of minima is not effective enough for forward-fitting the few visibilities sampled by STIX in the spatial frequency plane. Therefore, more sophisticated optimization schemes based on global search must be introduced for parametric imaging in the case of the Solar Orbiter X-ray telescope. The forward-fitting routine based on PSO proved to be significantly robust and reliable, and it could be considered as an effective candidate tool for parametric imaging in the STIX context., Astronomy & Astrophysics, 668, ISSN:0004-6361, ISSN:1432-0746

Introducción: Las fístulas durales arterio venosas (FAVd) etmoidales son infrecuentes, representan 6-10% de las FAVd y se caracterizan un alto riesgo de hemorragia con potenciales complicaciones neurológicas severas. Caso clínico: Paciente hombre, de 58 años, encontrado en domicilio con compromiso de conciencia. El estudio con TC de encéfalo muestra un extenso hematoma intracerebral frontal izquierdo con efecto de masa, en el estudio con angioTC de encéfalo se observa FAVd etmoidal. Se realiza cirugía de urgencia, evacuación de hematoma y desconexión de la FAVd. La angiografía cerebral de control postoperatorio no mostró fístula residual. Discusión: Las FAVd de piso anterior presentan un alto riesgo de hemorragia, dado el patrón de drenaje venoso, por lo cual se debe considerar el tratamiento. Dada la angioarquitectura de este tipo de FAVd son poco favorables para tratamiento endovascular, siendo la cirugía el tratamiento de elección.

We conducted the first taphonomic and paleoenvironmental study based on late Pleistocene–Holocene small mammal remains recovered from the famous Mylodon Cave (Cerro Benítez area, Última Esperanza, Chile). Most of the analyzed material came from the extensive excavations made by Earl Saxon in 1976. We also studied late Holocene small mammal samples of the neighboring rock shelter Dos Herraduras 1. Analyzed remains were mostly produced by owls, probably living inside the caves. In Mylodon Cave, the higher values of girdle bones are consistent with a windblown litter. We recorded nine species of rodents, seven cricetids, and two caviomorphs; almost all the identified taxa integrate recent local communities. Late Pleistocene–Holocene assemblages are characterized by the chinchilla ratEuneomys, indicating unforested areas around the caves under cold and moist climatic conditions. Middle Holocene amelioration is reflected by incremental rodent species richness, including the first record of taxa clearly associated with forest (e.g.,Abrothrix lanosa). Late Holocene assemblages are markedly stable, indicating local conditions similar to the current (historical) environment. Quaternary rodents from Cerro Benítez area do not indicate abrupt environmental changes during middle–late Holocene, but a progressive trend towards forest increase.

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Driving is a common activity with a significant impact on the quality of life since enables independence and fosters social activities. Nevertheless, driving is a rather complex task that requires different skills, such as physical abilities, proper judgement, risks perception / evaluation. Both these physical and cognitive abilities can be impaired after Multiple Sclerosis (MS) and can additionally be affected by the individual emotional state and disease progression. Driving simulators can be a good solution to assess and train driving skills of people with MS, but there are currently few studies focused on MS and driving ability. Moreover, they mostly aim at understanding driving performance impairments, mostly during monotonous highway drives. Here, we describe the framework of a new personalized driving simulator ADRIS 2.0, and the results of a first test on a group of unimpaired young adults and of a pilot test with three MS and sex and age-matched control subjects. Subjects trained with ADRIS 2.0 for a session of 30 minutes, driving through scenarios with different levels of difficulties. The system resulted easy to use and able to provide a realistic driving experience for all three groups of subjects. It also provided quantitative metrics that described MS drivers slower and prone to commit more infractions and collisions than control subjects. Thus, the developed simulator resulted well tolerated by all users, capable of detecting differences between control and MS subjects and its potential could be further exploited into the design of a personalized training of MS people.

El estudio que se presenta en este libro tiene como objetivos principales generar nuevo conocimiento en relación a la importancia del fuego en los planos material e ideológico de la sociedad Selk’nam y estudiar la preparación de los fogones en distintos contextos de uso de estos grupos cazadores-recolectores y de sus antecesores inmediatos, en el ambiente de la estepa septentrional de Tierra del Fuego. Se utilizan los antecedentes ambientales y etnográficos conocidos, así como la información arqueológica, antracológica, tafonómica, actualística y las dataciones obtenidas de los fogones y sus contextos. Se analizan 24 fogones de 9 sitios arqueológicos: Tres Arroyos 1, Tres Arroyos 4, Tres Arroyos 14, La 11, Marazzi 32, Marazzi 38, Bahía Inútil 3, Cabo San Vicente 9 y Punta Catalia 3. En este estudio se incluyen fogones de los Selk’nam del período histórico de contacto con los occidentales, de los siglos inmediatamente anteriores al contacto y algunos que pueden corresponder a las ocuapaciones Selk’nam más antiguas conocidas o bien de sus antecesores, en el rango aproximado de los últimos dos milenios. El estudio arqueológico de los fogones incluye cuatro niveles de análisis. El primer nivel se refiere al tamaño, potencia y forma de los 24 fogones. El segundo nivel considera el análisis del contenido interior de dichos fogones. El tercer nivel abarca el estudio de los fogones y sus asociaciones contextuales, desde la perspectiva micro espacial. Este análisis incluye los fogones Nos 12 y 13 de Tres Arroyos 14 y los fogones Nos 16, 17, 18 y 19 de Marazzi 32, vinculados a excavaciones ampliadas, con un completo registro en planta de artefactos y ecofactos. El último nivel trata la distribución espacial de las señales de fuego en el paisaje, a escala macroespacial de las localidades de Marazzi y Tres Arroyos. Finalmente, se integran y discuten los antecedentes reunidos mediante las distintas líneas disciplinarias desarrolladas en los capítulos del libro, en relación a los objetivos particulares planteados, visualizando las dificultades enfrentadas y proponiendo algunas conclusiones y proyecciones en relación al tema sometido a estudio. The main objectives of the study presented in this book are to generate new knowledge regarding the importance of fire in the material and ideological planes of Selk’nam society and to study the preparation of fireplaces in different contexts of use by these hunter-gatherer groups and their immediate predecessors, in the environment of the northern steppe of Tierra del Fuego. Known environmental and ethnographic antecedents are used, as well as archaeological, anthropological, taphonomic, and current information and data obtained from the hearths and their contexts. Twenty-four fireplaces from nine archaeological sites are analyzed: Tres Arroyos 1, Tres Arroyos 4, Tres Arroyos 14, La 11, Marazzi 32, Marazzi 38, Bahía Inútil 3, Cabo San Vicente 9 and Punta Catalia 3. This study includes Selk’nam hearths from the historical period of contact with Westerners, from the centuries immediately prior to contact and some that may correspond to the oldest known Selk’nam occupations or their predecessors, in the approximate range of the last two millennia. The archaeological study of the fireplaces includes four levels of analysis. The first level refers to the size, power and shape of the 24 fireplaces. The second level considers the analysis of the interior content of these hearths. The third level covers the study of the hearths and their contextual associations, from a microspatial perspective. This analysis includes hearths No. 12 and 13 of Tres Arroyos 14 and hearths No. 16, 17, 18 and 19 of Marazzi 32, linked to extended excavations, with a complete record of artifacts and ecofacts on the ground. The last level deals with the spatial distribution of fire signs in the landscape, on a macro-spatial scale of the localities of Marazzi and Tres Arroyos. Finally, the background information gathered through the different disciplinary lines developed in the chapters of the book is integrated and discussed in relation to the particular objectives set, visualizing the difficulties faced and proposing some conclusions and projections in relation to the subject under study. Fil: Massone Mezzano, Mauricio. Universidad de Magallanes; Chile. Prólogo – Introducción – Antecedentes -- Marco Teórico -- Objetivos y Metodología -- La información arqueológica sobre los fogones y sus contextos -- Antracología de los fogones -- - Experiencias actualísticas --Consideraciones tafonómicas – Conclusiones

Purpose of review: Coronavirus disease 2019 (COVID-19) is a well established respiratory tract illness. Recent studies in adults and children have shown an increasing number of patients reporting polymorphic cutaneous manifestations during COVID-19, including different types of rashes, from maculopapular, vascular, vesicular to atypical forms. Recent findings: Although pathogenesis of skin manifestations is still not fully understood, it has been proposed that cutaneous involvement during COVID-19 may be the results of the activation of the immune response against severe acute respiratory syndrome coronavirus-2, the reactivation or co-infection of herpesviruses or drug hypersensitivity. Summary: According to available literature, skin manifestations in patients with COVID-19 may be categorized on the basis of their clinical presentations as follows: erythematous rashes, lesions of vascular origin, vesicular rash, urticarial rash and acute generalized exanthematous pustulosis (AGEP), erythema multiforme and other polymorphic erythema/atypical reactions. Prompt recognition of these cutaneous manifestations represents a crucial point to facilitate diagnosis and management of COVID-19 patients.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R ⊙ above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvénic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

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The deterioration of water quality worldwide is a serious environmental problem. Water managers still need operational tools to assess water issues and to inform water planning and decision-making. The aim of this article is to propose a 3-step methodological framework for assessing water pollution problems by combining a conceptual modeling tool (DPSIR) with the development of a quantitative model (Multi-Criteria Decision Model). This contribution provides a practical and flexible evaluation tool for conducting an integrated assessment of eutrophication and agrochemicals delivered to groundwater-dependent shallow lakes. It lays out action guidelines for decision-making environmental managers within the context of intermediate cities in developing countries. Forty-one indicators were identified to characterize the D-P-S-I compartments and for the multi-criteria model conceptualization. In this work, response options analysis consisted of evaluating and choosing water management instruments via a decision support tool. Two lake watersheds located in the peri-urban of two middle-size cities, in Argentina, were chosen to illustrate this methodological approach. The ensuing results allowed establishing a ranking of areas to prioritize, identifying a criteria and sub-criteria to focus on in order to set out action guidelines to minimize water pollution and eutrophication. These action guidelines are urgently needed in emerging countries, where financial, human resources and infrastructure are limited. The scarcity of such causes important implications regarding policy solutions for environmental issues. The implemented decision support tool in both lake watersheds provided a common basis for the understanding of the ongoing water pollution problems and a quantitative ranking (i.e., decision scores) for defining specific actions (responses) for human-induced stresses on such natural systems.

Study design Multicentre cross-sectional study. Objective The objective of this study is to evaluate prevalence, location and characteristics of pain in hospital inpatients people with spinal cord injury (SCI). Setting Ten Italian rehabilitation centres specialized in spinal injury care, where inpatients are admitted both after the acute lesion and for late complications (time since injury, median [IQR]: 0.8 [0.2-8.2] years). Methods All the persons were submitted to AIS scale assessment [1] and modified Ashworth scale [2]; personal data and anamnesis were recorded; any pain within 1 week was investigated and the International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS) Italian version [3] was administered by physicians expert in type of pain definition. Results Of 385 included persons, 275 (72%) suffered pain, with the score value median [IQR]: 6 [4-8]. The worst pain of the person was nociceptive in 52% and neuropathic in 48% of the cases; 46% of nociceptive pain was located in the neck-shoulder region, whereas 67% of neuropathic pain was located in the sublesional part of the body. In 48% of the whole population, spasticity was observed but only 74% of them had pain. Being old and female are associated with high pain development, OR (95% CI): 1.24 (1.01-1.04) and 1.83 (1.05-3.20), respectively. Conclusions A high prevalence of pain is confirmed in persons with SCI, with both nociceptive and neuropathic pain characteristics. Only old age and female sex resulted as variables highly associated with pain.

Palliative care (PC) and hospice services have experienced shortages before 2020, and during the initial phases of the current pandemic, more critical gaps are expected with future surges, much as scarcity in intensive care unit services may recur during the COVID-19 pandemic. Although ethical allocation of ventilators and intensive care unit care is the subject of important discussions during this pandemic, caring for those at the end of life and those not desiring or qualifying for critical interventions must not be neglected, as critical care and comfort-focused care are intertwined. We review state and regional gaps already recognized in planning for scarcity in PC and hospice services during this pandemic and describe the planning initiatives Colorado has developed to address potential scarcities for this vulnerable and diverse group of people. We hope to encourage other state and regional groups to anticipate needs in the coming surges of this pandemic or in public health crises to come. Such planning is key to avoid the degradation of care that may result if it is necessary to invoke crisis standards of care and ration these essential services to our communities.

Oil spills, intrinsically related to the petroleum production chain, represent a risk to the marine environment and a potential threat to humans through seafood consumption. We revised the NE Brazil oil spill and other accidents along the Brazilian coast, with a focus on seafood contamination, covering topics such as bioaccumulation, bioaccessibility, and risk analysis. Comprehensive knowledge of the impacts of spills helps in the interpretation of the dynamics of hydrocarbons released into the sea, contributing to actions to control their negative impacts. Currently, no legal limits have been established permanently in Brazil for PAHs in seafood edible tissues.

Psoriasis is a complex disease often needing a multidisciplinary approach. In particular, the collaboration between dermatologist and rheumatologist is crucial for the management of patients suffering from both psoriasis (PSO) and psoriatic arthritis (PsA). Here we report a series of recommendations from a group of experts, as a result of a Consensus Conference, defining the circumstances in which it is preferable or even mandatory, depending on the available settings, to rely on the opinion of the two specialists, jointly or in a deferred manner. Indications are given on how to organize a 3rd level joint Dermatology- Rheumatology care unit, in connection with 1st and 2nd level clinicians of both specialties, GPs, and other specialists involved in the management of psoriasis. A potential patient journey is suggested, that can be used as a basis for future design and validation of national and/or local diagnostic therapeutic and assistance pathways.

Reinforced concrete structural walls (RCSWs) are one of the most efficient lateral force-resisting systems used in buildings, providing sufficient strength, stiffness, and deformation capacities to withstand the forces generated during earthquake ground motions. Identifying the failure mode of the RCSWs is a critical task that can assist engineers and designers in choosing appropriate retrofitting solutions. This study evaluates the efficiency of three ensemble deep neural network models, including the model averaging ensemble, weighted average ensemble, and integrated stacking ensemble for predicting the failure mode of the RCSWs. The ensemble deep neural network models are compared against previous studies that used traditional well-known ensemble models (AdaBoost, XGBoost, LightGBM, CatBoost) and traditional machine learning methods (Naïve Bayes, K-Nearest Neighbors, Decision Tree, and Random Forest). The weighted average ensemble model is proposed as the best-suited prediction model for identifying the failure mode since it has the highest accuracy, precision, and recall among the alternative models. In addition, since complex and advanced machine learning-based models are commonly referred to as black-box, the SHapley Additive exPlanation method is also used to interpret the model workflow and illustrate the importance and contribution of the components that impact determining the failure mode of the RCSWs.

Purpose With an increase in the number of adapted sports, the need to monitor sports performance in people with different abilities has grown. Indeed, a thorough evaluation of the sports gesture could prevent the occurrence of injuries, enable a continuous performance assessment, and allow to verify the compliance of the requirements for the competitions. Gesture kinematics provides an assessment of performance, while the muscle activities reveal the underlying strategies adopted by each athlete. In this context, we propose an instrumented evaluation to assess performance in Para-powerlifting. Our goal is to define and test a setup and a protocol to quantitatively assess the execution of bench press exercise in athletes with different abilities. Methods We recruited an unimpaired athlete and three Paralympic athletes. They were requested to execute the bench press exercise while we recorded muscle activity and kinematic data from the upper body. We investigated the sport gesture by extracting parameters describing coordination, symmetry, and synchronism between arms, and motor variability while repeating the gesture. Results Paralympic athletes performed the gestures with higher coordination between arms and low variability across repetitions compared to the unimpaired athlete, who was not at the Olympic level. All participants obtained similar kinematic performance by adopting different muscle strategies. Conclusions This study is a proof of concept that the instrumented evaluation proposed here can allow to conduct a complete assessment of the bench press exercise, in terms of kinematics, muscle activity and performance in athletes with different abilities.

Cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs) are usual epidermal tumours in dogs. CPs and CSCCs probably arise from the neoplastic transformation of the keratinocytes within the stem cell compartment, since these cells are the only keratinocytes that would reside long enough to accumulate the number of molecular alterations to drive the progression towards a tumour cell phenotype. However, the role of these cells in common epidermal tumours in dogs is still unknown. Thus, the purpose of this study was to evaluate the immunohistochemical expression pattern of p63 together with CK5, molecular markers of epidermal stem cells, on sections of tissue microarrays constructed from canine samples of CP and CSCC to investigate the contribution of stem cells in those canine tumours. p63/CK5 coexpression was retained in most basal and some suprabasal cells in CPs and CSCCs. In addition, increased coexpression of these molecules was observed in a group of CPs and CSCCs, as a result of a higher p63 expression. These results suggest that the coexpression of p63/CK5 may mark epidermal keratinocytes that possess self-renewal capacity rather than only stem cells, and suggest that transit amplifying cells, and even differentiated keratinocytes, may also contribute to the pathogenesis of epidermal tumours in dogs.