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Expression of the epidermal stem cell marker p63/CK5 in cutaneous papillomas and cutaneous squamous cell carcinomas of dogs
- Source :
- Research in Veterinary Science. 135:366-370
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs) are usual epidermal tumours in dogs. CPs and CSCCs probably arise from the neoplastic transformation of the keratinocytes within the stem cell compartment, since these cells are the only keratinocytes that would reside long enough to accumulate the number of molecular alterations to drive the progression towards a tumour cell phenotype. However, the role of these cells in common epidermal tumours in dogs is still unknown. Thus, the purpose of this study was to evaluate the immunohistochemical expression pattern of p63 together with CK5, molecular markers of epidermal stem cells, on sections of tissue microarrays constructed from canine samples of CP and CSCC to investigate the contribution of stem cells in those canine tumours. p63/CK5 coexpression was retained in most basal and some suprabasal cells in CPs and CSCCs. In addition, increased coexpression of these molecules was observed in a group of CPs and CSCCs, as a result of a higher p63 expression. These results suggest that the coexpression of p63/CK5 may mark epidermal keratinocytes that possess self-renewal capacity rather than only stem cells, and suggest that transit amplifying cells, and even differentiated keratinocytes, may also contribute to the pathogenesis of epidermal tumours in dogs.
- Subjects :
- Skin Neoplasms
040301 veterinary sciences
Cell
Biology
0403 veterinary science
Pathogenesis
03 medical and health sciences
Basal (phylogenetics)
Dogs
Biomarkers, Tumor
medicine
Animals
Neoplastic transformation
Dog Diseases
030304 developmental biology
0303 health sciences
Tissue microarray
Papilloma
integumentary system
General Veterinary
04 agricultural and veterinary sciences
stomatognathic diseases
medicine.anatomical_structure
Carcinoma, Squamous Cell
Cancer research
Epidermal stem cell
Immunohistochemistry
Stem cell
Subjects
Details
- ISSN :
- 00345288
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Research in Veterinary Science
- Accession number :
- edsair.doi.dedup.....9bb8adef42d61d634fd7ccad76616419