61 results on '"M.D. López"'
Search Results
2. Protocolo diagnóstico y terapéutico del pie diabético
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M.D. López Carmona, A. López Sampalo, and L. Cobos Palacios
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,medicine ,030212 general & internal medicine ,General Medicine ,business - Abstract
espanolTodos los pacientes diabeticos han de ser examinados para identificar el riesgo de ulceracion del pie. Es necesario realizar un reconocimiento temprano y un manejo de los factores de riesgo que predicen un mayor riesgo de amputaciones, siendo la mayoria de estos factores facilmente identificables a traves de la historia clinica, asi como realizar un examen fisico completo del pie de forma anual que incluya inspeccion, evaluacion de pulsos y de sensibilidad. El abordaje terapeutico del pie diabetico requiere de una evaluacion y estratificacion de riesgo previa, en la que se valora la extension y profundidad de la lesion, asi como la presencia de isquemia o infeccion, lo que va a determinar la actitud terapeutica. El cultivo de muestras de la ulcera puede acotar tanto el tiempo como el espectro de la antibioterapia. El manejo integral del pie diabetico incluye un control glucemico estricto, medidas locales y antibioterapia sistemica. EnglishAll diabetic patients have to be screened in order to assess their risk of diabetic foot ulcers. Early identification and management of risk factors for foot amputations is required, easily identifiable by clinical history. Yearly comprehensive physical examination, including foot inspection, foot pulse palpation and foot sensitivity assessment, is also necessary. Therapeutic approach requires prior risk assessment and staging, assessing the extent and depth of the injury, as well as the presence of ischemia or infection. Antibiotic therapy may be reduced by the culture of ulcer samples. Comprehensive management of diabetic foot includes strict glycemic control, local measures and systemic antibiotic therapy.
- Published
- 2020
3. Neuropatía diabética
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L. Cobos-Palacios, A. López Sampalo, and M.D. López Carmona
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General Medicine - Published
- 2020
4. High temperature corrosion and wear behavior of HVOF-sprayed coating of Al2O3-NiAl on AISI 304 stainless steel
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M.D. López, Antonio López, N. Abu-warda, and M.V. Utrilla
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Nial ,Materials science ,020209 energy ,Oxide ,02 engineering and technology ,Temperature cycling ,engineering.material ,Corrosion ,chemistry.chemical_compound ,Coating ,0202 electrical engineering, electronic engineering, information engineering ,Materials Chemistry ,Thermal spraying ,computer.programming_language ,High-temperature corrosion ,Spinel ,Metallurgy ,Surfaces and Interfaces ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Surfaces, Coatings and Films ,chemistry ,engineering ,0210 nano-technology ,computer - Abstract
High velocity oxy-fuel (HVOF) technique was used to deposit an Al2O3-30(Ni20Al) coating on AISI 304 stainless steel substrate to improve its corrosion and wear performance at high temperature. First, thermal cycling tests at 750 and 850 °C were conducted in air atmosphere on both coated and uncoated stainless steel substrates to study the effectiveness of coating protection system at different exposure times (2, 6, 10 and 15 days). Then, high temperature corrosion and wear mechanisms were studied by SEM and XRD techniques. These analyses revealed that uncoated specimens were severely corroded but no oxidation on the coated substrates was detected. Oxide growth on the uncoated substrate was mainly formed by spinel (MnCr2O4 and FeCr2O4) and corundum (Fe2O3 and Cr2O3) type oxides. Meanwhile, these oxides were not found on the coated substrate. Wear rate of the coated specimen was found to be reduced from 6.9·10−4 to 8.3·10−5 mm3/N·m compared to that of the uncoated specimen. The exposure to high temperatures improved coating wear resistance: wear rate was four times lower in the coated sample exposed to high temperatures compared to that of the non-exposed coated sample due to the formation of a harder phase of NiO.
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- 2019
5. List of Contributors
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Samuel Chetachukwu Adegoke, Carlos Álvarez, Christa Aoude, Violaine Athès-Dutour, Giulia Baldi, Francisco J. Barba, Nastasia Belc, Lorenzo Bertin, Chiranjib Bhattacharjee, Sangita Bhattacharjee, Silvia Alvarez Blanco, Hoe Boon Chin, Mladen Brnčić, Camelia Bucatariu, Anda-Gratiela Burnete, María de la Luz Cádiz-Gurrea, Débora A. Campos, Alfredo Cassano, Luminita Catana, Monica Catana, Sudip Chakraborty, Smain Chemat, Ooi Chien Wei, Alina Culetu, P.J. Cullen, Patrick J. Cullen, Isabel C.N. Debien, Maria Dolores del Castillo, Cristina Delerue-Matos, Qian Deng, Stella Despoudi, Beatriz Díaz-Reinoso, Carla Daniela Di Mattia, D.A. Dimitrov, Herminia Domínguez, Denisa Eglantina Duta, Elena Falqué, Milad Fathi, S. Fayaz, Federica Flamminii, Dario Frascari, Charis M. Galanakis, Francesca Gallotti, C. García-Viguera, Lia Noemi Gerschenson, Adem Gharsallaoui, Rodrigo Gonzalez-Ortega, Nabil Grimi, Tamara Dapčević Hadnađev, Ching Lik Hii, Henry Jaeger, Seid Mahdi Jafari, Paula Jauregi, Canan Kartal, Attila Kovács, Vera Lavelli, Alexandra-Monica Lazar, P. Lema, M.D. López, Abid Aslam Maan, Dimitris P. Makris, H.A. Makroo, Ioanna Mandala, Nuria Martinez-Saez, Dino Mastrocola, Inmaculada Mateos-Aparicio, M. Angela A. Meireles, N.N. Misra, Vassiliki S. Mitropoulou, D.A. Moreno, Andrés Moure, Marwen Moussa, Anne Maria Mullen, Jayesree Nagarajan, F. Naqash, Arijit Nath, Akmal Nazir, Chien Wei Ooi, Semih Otles, I.N. Panchev, Maria Papageorgiou, E. Paulsen, Davide Pedrali, Maria Angela Perito, Massimiliano Petracci, Diana Pinto, Paola Pittia, Milica Pojić, Juliana M. Prado, Krishnamurthy Nagendra Prasad, Eduardo Puértolas, Francisca Rodrigues, Francisco Amador Riera Rodriguez, M.E. Romero, Julia Schmidt, Muhammad Nouman Shaukat, Ana Margarida Silva, Francesca Soglia, Isabelle Souchon, H.B. Sowbhagya, Giorgia Spigno, Reza Tahergorabi, Renata Vardanega, Hiroshi Yoshida, and Rui Zhang
- Published
- 2021
6. Foods and supplements
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E. Paulsen, M.E. Romero, P. Lema, M.D. López, C. García-Viguera, and D.A. Moreno
- Published
- 2021
7. IMPULSIVITY, SMARTPHONE ADDICTION AND ITS RELATIONSHIP WITH ACADEMIC PERFORMANCE
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P. Fernández-Martín, J. Leon, J. López Puga, M.D. López Salmerón, A.M. Ruiz-Ruano García, P. Flores Cubos, and A. Sánchez-Kuhn
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Smartphone addiction ,medicine ,medicine.symptom ,Impulsivity ,Psychology ,Clinical psychology - Published
- 2020
8. Protocolo diagnóstico y cuantificación de los factores de riesgo cardiovascular
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M.D. López Carmona, L. Cobos Palacios, and L. Caballero Martínez
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business.industry ,Medicine ,General Medicine ,business ,Humanities - Abstract
Resumen Introduccion El riesgo cardiovascular (CV) global se define como la probabilidad de presentar un evento CV en un periodo determinado, y es considerado por todas las sociedades cientificas como el metodo mas adecuado para evaluar la enfermedad aterosclerotica. Cuantificacion del riesgo Existen diferentes tablas de calculo, basadas en otros tantos factores de riesgo, que deberan ser evaluados en los pacientes antes de realizar ninguna recomendacion. Entre los factores de riesgo modificables se debe realizar una deteccion de hipertension arterial (HTA), diabetes, dislipemias, tabaquismo y sobrepeso/obesidad, ya que a ellos iran dirigidos nuestros esfuerzos terapeuticos. Objetivo El siguiente protocolo resume de manera practica el diagnostico de los distintos factores de riesgo, asi como el calculo y la interpretacion de las principales tablas de riesgo CV aplicables a la poblacion espanola.
- Published
- 2017
9. ¿Qué hemos hecho en nuestra UCI de Anestesia para mantener la comunicación en la pandemia?
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E. Mateo Rodríguez, M.D. López Alarcón, C Baixauli Soria, and M Á Celda Moret
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Critical Care and Intensive Care Medicine ,medicine.disease_cause ,Anesthesiology and Pain Medicine ,Emergency medicine ,Pandemic ,medicine ,business ,Coronavirus - Published
- 2020
10. Apolipoprotein A-IV measurements in paired venous and fingerprick blood samples: Agreement analysis
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Eva Pardina, N. Virgili, A.M. Pita, J. Ruiz, M.D. López-Tejero, Jordi Targarona, and A. Viñas
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Male ,Short Bowel Syndrome ,Blood Specimen Collection ,Chromatography ,Chemistry ,Biochemistry (medical) ,Clinical Biochemistry ,Agreement analysis ,General Medicine ,Middle Aged ,Apolipoprotein A-IV ,Biochemistry ,Humans ,Female ,Apolipoproteins A ,Biomarkers ,Blood Chemical Analysis - Published
- 2020
11. Diagnóstico de Responsabilidad Social Empresarial: caso de estudio de la microempresa Instawatch
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S. Cruz Castro, L. A. Peraza Pérez, P. G. Baqueiro López, M.D. López Noriega, and L. Zalthen Hernández
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buenas prácticas ,Mipymes ,responsabilidad social empresarial - Abstract
En el presente trabajo se analiza el caso de estudio de la microempresa comercial Instawatch con la finalidad de determinar el nivel de responsabilidad social empresarial (RSE) de la organización mediante la aplicación de un cuestionario en el que se identifican las prácticas de RSE que se llevan a cabo dentro de la misma. Para llevar a cabo este trabajo de investigación, se realizó un estudio descriptivo no experimental el cual se encuentra dividido en tres partes: la primera de ellas consiste en la elaboración del marco teórico; la segunda parte es la recopilación de información; y, la tercera el análisis de los datos obtenidos. Por último, con base a los resultados obtenidos del análisis, se identificó la situación en que se encuentra la empresa respecto a la RSE en el que se encuentra la empresa. 
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- 2019
- Full Text
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12. Tratamiento del dolor irruptivo con fentanilo sublingual en pacientes con úlceras cutáneas crónicas
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F. Palomares Payá, L. Debón Vicent, C. Alba Moratillas, V. Domingo-Triadó, B. Massa Domínguez, M.D. López Alarcón, A. Mínguez Martí, and F. Villegas Estévez
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Anesthesiology and Pain Medicine ,business.industry ,Medicine ,Critical Care and Intensive Care Medicine ,business ,Humanities - Abstract
Resumen Objetivo El presente estudio pretende establecer la eficacia y tolerabilidad de los opioides en el tratamiento del dolor en pacientes con ulceras cutaneas cronicas y dolor irruptivo incidental. Material y metodo Estudio abierto, multicentrico, prospectivo, no controlado, realizado en unidades del dolor y de ulceras de 5 hospitales de la Comunidad Valenciana. El criterio de inclusion fue dolor basal mayor o igual a 4 segun la escala visual analogica o dolor irruptivo mayor o igual a 4 durante la cura. Los criterios de exclusion fueron alteraciones cognitivas, intolerancia a opioides y rechazo del paciente a dar el consentimiento. El protocolo establecio 5 momentos de evaluacion: basal (primera visita), 15 dias, un mes, 2 y 3 meses. La variable principal del estudio fue el dolor medido con la escala visual analogica en reposo, en movimiento y durante la cura. Se administraron opioides para el dolor basal y se administro fentanilo sublingual para el dolor irruptivo. Resultados Treinta y dos pacientes (86,5%) completaron el estudio. El dolor basal experimento una reduccion media de 3,6 (DE 2,3) puntos en la escala visual analogica, el dolor en movimiento disminuyo 3,9 (DE 2,5), y el dolor durante la cura disminuyo 4,5 (DE 2,8), siendo en todos estadisticamente significativa (p Conclusiones Los resultados de nuestro estudio evidencian que el tratamiento con opioides en pacientes con ulceras cutaneas cronicas proporciona un alivio efectivo del dolor, tanto basalmente como durante la cura, con escasos efectos adversos.
- Published
- 2014
13. Diabetes en el anciano: primun non nocere
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R. Gómez-Huelgas and M.D. López-Carmona
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Medicine ,030209 endocrinology & metabolism ,030212 general & internal medicine ,General Medicine ,business - Published
- 2017
14. EVALUATION OF INTERDISCIPLINARY PROJECTS IN PRE-PRIMARY EDUCATION DEGREE
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A. Calonge García, O. de la Cruz Vicente, and M.D. López Carrillo
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Pedagogy ,Primary education ,Engineering ethics ,Sociology ,Degree (temperature) - Published
- 2016
15. Daily spawning and locomotor activity rhythms of European sea bass broodstock (Dicentrarchus labrax)
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Francisco Javier Sánchez-Vázquez, M.D. López, M. Herlin, and Natalia Villamizar
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urogenital system ,media_common.quotation_subject ,Period (gene) ,fungi ,Zoology ,Broodstock ,Aquatic Science ,Biology ,Nocturnal ,biology.organism_classification ,Hatchery ,Fishery ,Dicentrarchus ,sense organs ,Sea bass ,Reproduction ,Diel vertical migration ,reproductive and urinary physiology ,media_common - Abstract
Fish have an internal biological clock that drives their daily rhythms, including those of feeding and reproduction. The European sea bass has been reported to exhibit a phase inversion of its diel feeding pattern: nocturnal in winter (coinciding with the spawning period) and diurnal during the remainder of the year. In this study, we investigated the locomotor activity of sea bass during the spawning and resting periods as well as the possible existence of a daily spawning rhythm by calculating the number of eggs (and their viability) released every hour. The results showed that sea bass locomotor activity was clearly nocturnal (68 ± 4.3% of the daily activity displayed at night) during the spawning season and mostly diurnal (65.5 ± 7.5% of the activity displayed during the day) out of the reproductive period. Spawning occurred during the dark phase with two peaks, 6 and 11 h after lights off. Egg viability was highest in the batch released near the spawning peaks. These findings could be useful for optimizing egg production and to improve hatchery practices, which should take into account the reproduction rhythms of sea bass.
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- 2012
16. Selection for tolerance to volatile monoterpenoids in Sitophilus oryzae (L.), Rhyzopertha dominica (F.) and Cryptolestes pusillus (Schönherr)
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M.J. Pascual-Villalobos, J. Contreras, and M.D. López
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biology ,Sitophilus ,food and beverages ,Horticulture ,biology.organism_classification ,Fenchone ,chemistry.chemical_compound ,Camphor ,chemistry ,Linalool ,Insect Science ,Botany ,Bostrichidae ,Estragole ,Agronomy and Crop Science ,Anethole ,Geraniol ,Food Science - Abstract
Selection for tolerance to 8 monoterpenoids (linalool, camphor, γ-terpinene, S-carvone, geraniol, estragole, E-anethole, and fenchone) in three pests of stored rice, Sitophilus oryzae, Rhyzopertha dominica and Cryptolestes pusillus, as well as the metabolic mechanisms implicated, was studied. Strains were selected for tolerance towards each monoterpenoid from susceptible insect populations for each of seven generations. After selection, tolerance was observed towards linalool, S-carvone and estragole in S. oryzae and towards camphor in C. pusillus. Populations of R. dominica were not observed to develop tolerance to monoterpenoids. The activity of three enzymatic systems detoxifying these monoterpenoids, microsomal P-450 monooxygenase, esterase, and glutathione S-transferase (GST), were analyzed to study the metabolic mechanisms involved. Esterases could be involved in S. oryzae tolerance whereas P-450 monooxygenases could be involved for most monoterpenoids in selected populations of R. dominica and C. pusillus.
- Published
- 2010
17. Corrosion resistance of thermally sprayed Al and Al/SiC coatings on Mg
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Enrique Otero, Belen Torres, Mónica Campo, M.D. López, Joaquín Rams, M. Carboneras, and P. Rodrigo
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Materials science ,Orders of magnitude (temperature) ,Magnesium ,Metallurgy ,Composite number ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Corrosion ,chemistry.chemical_compound ,stomatognathic system ,chemistry ,Aluminium ,Materials Chemistry ,Silicon carbide ,Porosity ,Thermal spraying - Abstract
Thermally sprayed Al and Al/SiC composite coatings have been deposited on pure magnesium and their corrosion behaviour in 3.5 wt.% NaCl solution has been studied. Al/SiC composite coatings were fabricated with 9 vol.% reinforcement percentage and with porosities around 3.5%, while the porosity of the as-sprayed pure Al coatings was in the range 2.4 vol.% to 4.4 vol.% and depended more on the spraying distance and numbers of layers deposited. A mechanical compaction was applied to the coatings at room temperature and coatings that were nearly free from pores were fabricated for the Al and Al/SiC coatings. In the electrochemical tests, all the coatings showed higher corrosion potentials (about of 200 mV) than uncoated substrates while current densities were nearly two orders of magnitude lower for the Al/SiC composite coatings and three orders of magnitude lower for the pure aluminium coatings. This protective effect was even better in the compacted coatings, currents densities were between five or six orders of magnitude lower than that of uncoated magnesium.
- Published
- 2009
18. Validación farmacéutica y detección de errores de prescripción de antineoplásicos en pacientes oncohematológicos
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I. Fernández García, M.D. López-Malo de Molina, B. Isla Tejera, J. Abellón Ruiz, and M.C. Garzás-Martín de Almagro
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Pharmacology ,medicine.medical_specialty ,Pediatrics ,business.industry ,Haematology department ,medicine ,Observational study ,Medical prescription ,business ,Surgery ,Type I and type II errors ,Incorrect dose - Abstract
Objective: To identify the different types of cytostatic prescription errors in adult and paediatric oncohematological patients in our hospital and to propose strategies for improvement. Methods: Longitudinal, prospective, observational study in which prescriptions for antineoplastics from the haematology and paediatric oncohaematology departments were validated over a 15-month period. The types of error were classified in accordance with the terminology and taxonomy published by Otero and cols in the document “Medication errors: standardisation of terminology and classification”. Eleven variables were recorded. Amongst other parameters, the following were determined: percentage of overall error, percentage of error in type of prescription, percentage of service error, percentage of pharmaceutical intervention and level of acceptance. Results: A total of 92 errors were recorded which corresponded to 1.4% of the total prescriptions. The most significant errors were: incorrect dose (28.2%), incorrect duration (21.7%), incorrect volume and/or inadequate vehicle (16.3%), and in one case a prescription was made up where the patient was allergic to the specific cytostatic drug prescribed. 81.8% of prescription errors were made manually. In the haematology department a 0.9% error was recorded, as was a 3.5% error in paediatric oncohaematology. Both the rate of pharmaceutical intervention and its level of acceptance were 100%.
- Published
- 2008
19. Adsorptive stripping square wave voltammetry (Ad-SSWV) accomplished with second-order multivariate calibration
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A. Guiberteau-Cabanillas, Teresa Galeano-Díaz, M.D. López-Soto, and Anunciación Espinosa-Mansilla
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Detection limit ,Analyte ,Oxon ,Chromatography ,Stripping (chemistry) ,Analytical chemistry ,Square wave ,Dropping mercury electrode ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Partial least squares regression ,Environmental Chemistry ,Voltammetry ,Spectroscopy - Abstract
A method, using stripping square wave voltammetry (Ad-SSWV), for the simultaneous determination of fenitrothion (FEN) and its metabolites: fenitrooxon (OXON) and 3-methyl-4-nitrophenol (3-MET) in environmental samples is reported. All three compounds produce, at mercury electrode (HMDE), an electrochemical signal due to an adsorptive–reductive process. The electrochemical approach shows a very high overlap degree for FEN and OXON voltammograms, however the adsorption kinetic profile could be used as an additional differential variable between both analytes. Second-order multivariate calibration has been tested to solve the mixture of the three compounds. The second-order assayed methods were parallel factor analysis (PARAFAC), unfolded partial least squares (U-PLS), multidimensional partial least squares (N-PLS) and the latest ones were used in combination with the residual bilinearization procedure RBL. U-PLS/RBL model was stated as the best second-order algorithm for the simultaneous determination of these three compounds up to 50 ng mL −1 for each analyte. The detection limits and recovery values were 1.6 ng mL −1 and 92 ± 7% for FEN; 3.7 ng mL −1 and 101 ± 9% for OXON and 0.6 ng mL −1 and 97 ± 8% for 3-MET.
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- 2008
20. Protection against corrosion of aluminium-SiC composites by sol–gel silica coatings
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Alejandro Ureña, M.D. López, Joaquín Rams, and Antonio López
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Materials science ,Scanning electron microscope ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,engineering.material ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Dielectric spectroscopy ,Corrosion ,chemistry ,Coating ,Aluminium ,Materials Chemistry ,engineering ,Gravimetric analysis ,Composite material ,Polarization (electrochemistry) ,Sol-gel - Abstract
Silica mono-and multilayered coatings have been obtained through a sol–gel route on aluminium matrix composites reinforced with SiC particles for their corrosion protection. Tetraethoxysilane (TEOS) was used as alcoxide precursor, and dip-coating technique of the samples was used at different extraction rates. Corrosion protection of the different coating systems have been evaluated in 3.5 wt.% NaCl at different immersion times using several electrochemical techniques including linear polarization resistance, anodic–cathodic polarization, and electrochemical impedance spectroscopy. Gravimetric tests have been also used to characterize the protective effectiveness of the coatings, using low angle X-ray diffraction to identify the corrosion products. Coatings characterization before and after corrosion tests have been carried out using Scanning Electron Microscopy and Atomic Force Microscopy, studying the mechanisms of corrosion that take part in coated and uncoated composites. A corrosion mechanism for each one of the tested materials has been proposed.
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- 2008
21. Estudio comparativo del burnout en personal de enfermería de Cuidados Intensivos y Urgencias
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M.I. Ríos Risquez, P. Simón Domingo, E. Salmerón Saura, R. Liébanas Bellón, R. Ruiz Sánchez, C. Godoy Fernandez, F. Peñalver Hernández, S. Garnés González, A.R. Alonso Tovar, M.A. Menchón Almagro, M.D. López Real, J.L. Manzanera Nicolás, A. López Romera, and F. López Alcaraz
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Critical Care and Intensive Care Medicine ,Critical Care Nursing ,Psychology ,Humanities - Abstract
Objetivo Estimar y comparar el nivel de burnout existente en los Servicios de Cuidados Intensivos y Urgencias, y estudiar su asociacion con las caracteristicas sociodemograficas y laborales de los profesionales encuestados. Diseno Estudio descriptivo transversal. Emplazamiento Servicios de Urgencias y Cuidados Intensivos del Hospital Morales Meseguer (Murcia). Muestra . Noventa y siete profesionales de enfermeria, 55 pertenecientes al Servicio de Urgencias y 42 al Servicio de Cuidados Intensivos. Metodo Se emplearon dos instrumentos de evaluacion: una encuesta de variables sociodemograficas y laborales, y el cuestionario Maslach Burnout Inventory , de 1986. Las variables cuantitativas se expresan como media ± desviacion estandar comparadas con t de Student y las cualitativas se comparan con Chi 2 . El analisis de datos se realizo mediante el programa informatico SPSS 12.0 © . Resultados El analisis comparativo de las dimensiones que componen el burnout demuestra que los niveles de agotamiento emocional son significativamente mayores en el Servicio de Cuidados Intensivos que en el de Urgencias (25,45 ± 11,15 frente a 22,09 ± 10,99) p Conclusiones Los niveles encontrados de burnout resultaron ser moderadosaltos. El 5,15% de la muestra total estudiada puntua alto en las tres dimensiones del sindrome, los profesionales de Cuidados Intensivos son los mas vulnerables a padecer elevados niveles de agotamiento emocional y el genero masculino es el mas propenso a las actitudes de despersonalizacion.
- Published
- 2008
22. Contents Vol. 121, 2008
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I. Babić, K. Kumke, P. Sirleto, M. Guerra, E. Gebhart, X. Liang, F. Pelliccia, A. Curatolo, L.-Y. Li, G. Queipo, C. Kopp, I. Palma, C. Soderberg, A.G. O’Reilly, K. Nieto, M. Kapović, M. Volleth, S.B. Olson, P.A. Wheeler, C.M. Ramsdell, E. Capanna, M.D. López-León, T. Sato, G. Emmert, N. Bosco, R.J. O’Neill, P. Grzmil, R. de la Herrán, N. Ohkohchi, P.C.M. O’Brien, E. Matoso, J.I. Navas, M. Switonski, R.E. Moses, Y.R. Peña, T.E. Mirkov, T.V. Karamysheva, L. Chavez, T. Matsumoto, A. Rocchi, A.G. Bugrov, H. Mizuno, I.M. Carreira, H. Tönnies, J. Hejna, J. Olvera, D.S. Perez, S. Kofman-Alfaro, C. Ruiz Rejón, M.C. Digilio, I.Y. Iourov, E. Aygören-Pürsün, R.N. Jones, R.B. Phillips, Y.B. Yurov, W. Rens, N.B. Rubtsov, A. Hemphill, R. Castiglia, A. Lombardo, J. Nowacka-Woszuk, H. Kiyosawa, C.J. Obergfell, T. Sasaki, J. Rubes, M.J. Julião, G.H. Thorgaard, I. López-Flores, M. Andersson, K. Bork, I. Szczerbal, A.C. Tomaiuolo, B. Brajenović-Milić, T. Rzymski, M. Kubo, M.J. O’Neill, K. Mrasek, K.-L. Sun, C.R. Müller, J. Saraiva, Y.M.N. Akkari, Z. Modrušan-Mozetić, J. Vraneković, J. Li-Ling, V.V. Monakhov, G. Krüger, I. Martinez-Saguer, H. Yasue, Z.-G. Li, A. Kocot, M.A. Alfaqih, J. Cabrero, J. Müller-Navia, O.C. Ukpo, E.J. Moore, M.J. Dewey, W. Kreuz, N. Nájera, A. Meinhardt, I.V. Soloviev, E. Rusicke, M. Ruiz Rejón, T. Liehr, A. Weise, A.P. Moraes, J.P.M. Camacho, W.-N. Fu, M. Herrera, I. Bauer, A. Mascarenhas, L.-L. Wang, V.V. Dzyubenko, M.A. Garrido-Ramos, A.E. Hanlon Newell, S. Wolf, D. Kademani, E. Gornung, H. Cernohorska, T. Göβwein, A. Gerlach, A.H. Rezaeian, J.B. Melo, J. Oldenburg, F. Robles, T. Miura, E.E. Mlynarski, A. Houben, R. Capolino, D. Aguirre, P. Burfeind, D.I. Smith, A. Angioni, M.C. Roberti, M. Chiba, I. Hachero, C. Surace, J. Sosnowski, and S.G. Vorsanova
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Botany ,Genetics ,Zoology ,Biology ,Molecular Biology ,Genetics (clinical) - Published
- 2008
23. Prediction of Total Soluble Solid Content in Intact and Cut Melons and Watermelons Using near Infrared Spectroscopy
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M.D. López, Ana Garrido-Varo, J. E. Guerrero, Dolores Pérez-Marín, K. Flores, and María-Teresa Sánchez
- Subjects
Materials science ,Soluble solids ,Reflectance spectroscopy ,Near-infrared spectroscopy ,Analytical chemistry ,Calibration ,Spectroscopy ,Near infrared radiation - Abstract
There is currently a growing tendency for fruit to be classified and marketed in accordance with quality criteria. One parameter used to evaluate quality in melons and watermelons is total soluble solid content, measured by invasive analytical methods which are incompatible with current quality-assurance requirements for individual pieces of fruit. Use of near infrared (NIR) reflectance spectroscopy as a nondestructive technique for measuring total soluble solid content could therefore be of considerable interest to the fruit and vegetable sector. The present study assesses the use of a NIR diode array spectrometer for estimating total soluble solid content (°Brix) in intact and cut melons and watermelons. NIR calibration models were developed using two sets for each fruit, a 2006 set ( N = 158) and a 2007 set ( N=415) for melon samples and a 2006 set ( N=77) and 2007 set ( N = 183) for watermelon samples, grown in El Ejido (Almeria, Spain). The predictive ability of the calibrations developed were greater for cut fruit ( SECV= 0.60°Brix, r2 = 0.88, RPD=2.94 in melons and SECV = 0.49 °Brix, r2 = 0.85, RPD=2.50 in watermelons) than for intact fruit (SECV = 0.98°Brix, r2 = 0.76; RPD=2.05 in melons and SECV= 0.93°Brix, r2 = 0.65, RPD = 1.69 in watermelons). This study demonstrates the value of NIR spectroscopy for grading cut melons and watermelons, intact melons and possibly intact watermelon fruits into categories of high, medium and low levels of sweetness.
- Published
- 2008
24. Pharmaceutical Validation and Error Detection in the Prescription of Antineoplastics in Oncohaematological Patients
- Author
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M.D. López-Malo de Molina, B. Isla Tejera, M.C. Garzás-Martín de Almagro, J. Abellón Ruiz, and I. Fernández García
- Subjects
medicine.medical_specialty ,Haematology department ,business.industry ,Emergency medicine ,medicine ,Cytostatic drugs ,Observational study ,Medical prescription ,Error detection and correction ,business ,Surgery ,Incorrect dose ,Type I and type II errors - Abstract
Objective To identify the different types of cytostatic prescription errors in adult and paediatric oncohaematological patients in our hospital and to propose strategies for improvement. Methods Longitudinal, prospective, observational study in which prescriptions for antineoplastics from the haematology and paediatric oncohaematology departments were validated over a 15-month period. The types of error were classified in accordance with the terminology and taxonomy published by Otero and cols in the document “Medication errors: standardisation of terminology and classification.” Eleven variables were recorded. Amongst other parameters, the following were determined: percentage of overall error, percentage of error in type of prescription, percentage of service error, percentage of pharmaceutical intervention, and level of acceptance. Results A total of 92 errors were recorded which corresponded to 1.4% of the total prescriptions. The most significant errors were: incorrect dose (28.2%), incorrect duration (21.7%), incorrect volume and/or inadequate vehicle (16.3%), and in 1 case a prescription was made up where the patient was allergic to the specific cytostatic drug prescribed. Eighty-one point eight percent of prescription errors were made manually. In the haematology department a 0.9% error was recorded, as was a 3.5% error in paediatric oncohaematology. Both the rate of pharmaceutical intervention and its level of acceptance were 100%.
- Published
- 2008
25. Wear resistance of multilayered sol–gel silica layers on aluminium matrix composites
- Author
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Joaquín Rams, M.D. López, Antonio López, and Alejandro Ureña
- Subjects
Materials science ,Composite number ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Corrosion ,Wear resistance ,chemistry ,Aluminium ,visual_art ,Materials Chemistry ,visual_art.visual_art_medium ,Deposition (phase transition) ,Ceramic ,Composite material ,Sol-gel ,Aluminium matrix - Abstract
Sol–gel silica coatings have been developed, using a dip-coating process to provide corrosion and wear resistance to aluminium composites reinforced with SiC particles. Pin-on-disk tests indicate that these ceramic coatings reduce the adhesive wear between the steel pin and composite. The coatings extracted at lower deposition speeds are thinner than those extracted at faster speeds, but they show better wear resistance which can be explained by their greater hardness caused by a better consolidated structure.
- Published
- 2007
26. Characterisation of multilayered sol–gel silica coatings on aluminium–SiC composites
- Author
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M.D. López, Alejandro Ureña, Joaquín Rams, and Antonio López
- Subjects
Materials science ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Substrate (electronics) ,Nanoindentation ,Condensed Matter Physics ,Microstructure ,Surfaces, Coatings and Films ,chemistry ,Nanocrystal ,Aluminium ,Materials Chemistry ,Composite material ,Layer (electronics) ,Elastic modulus ,Sol-gel - Abstract
Silica coatings up to 20 μm thick have been obtained through a sol–gel route on aluminium matrix composites reinforced with SiC particles. Single silica layer and multiple ones have been deposited on the substrates and extensive crack-free surfaces have been achieved with both methods. The topography of the layers has been characterised by means of Scanning Electronic Microscopy and Atomic Force Microscopy, and dense flat surface has been observed. However, topographical details consisting of spherical zones tend to appear on the surface of multilayered coatings. The mechanical properties of the different coatings have been measured using the nanoindentation technique independently from the substrate underneath, and hardness and elastic modulus similar and even higher than those of fused silica have been obtained for sol–gel multilayered coatings. The microstructure of the coatings has been studied by Transmission Electronic Microscopy, and the appearance of nanocrystals on the flat surfaces has been considered responsible of the mechanical properties measured.
- Published
- 2006
27. Diagnóstico diferencial del estreñimiento crónico. A propósito de un caso
- Author
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M.D. López Crespo, J.P. Almeida Rebollo, A. Caballero Carrasco, and R. Blasco Montero
- Subjects
Public Health, Environmental and Occupational Health ,Family Practice - Abstract
El estrenimiento cronico supone un motivo frecuente de consulta en Atencion Primaria y de automedicacion, pues hasta un 20% de los pacientes mayores de 65 anos emplean laxantes de forma regular. Debido a las multiples causas que lo pueden producir; principalmente trastornos funcionales y, en menor medida, otras causas como la ingesta de farmacos, enfermedades digestivas o extradigestivas y ante la relevancia de las mismas, debemos realizar una buena anamnesis, exploracion y seguimiento de este, intentando llegar al diagnostico etiologico valorando los signos de alarma y solicitando pruebas complementarias ante la sospecha de origin organico. El pronostico en algunas ocasiones podria depender de la precocidad con la que se diagnostique; vease en nuestra paciente, cuya evolucion fue favorable debido al diagnostico y tratamiento precoz del pseudomixoma peritoneal.
- Published
- 2006
28. Determination of Dimethoate in Olive Oil by Adsorptive Stripping Square-Wave Voltammetry
- Author
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M.D. López Soto, T. Galeano Díaz, J. M. Ortiz, and A. Guiberteau
- Subjects
Detection limit ,chemistry.chemical_compound ,Chromatography ,Stripping (chemistry) ,Chemistry ,Standard addition ,Extraction (chemistry) ,Electrochemistry ,Response surface methodology ,Dimethoate ,Voltammetry ,Analytical Chemistry ,Olive oil - Abstract
A method for the determination of dimethoate in olive oil by adsorptive stripping square-wave voltammetry has been developed on the base that this pesticide is hydrolyzed in basic media giving rise to an adsorptive-reductive peak at −0.780 V. Extraction of dimethoate from olive oil with ethanol-water and posterior clean-up with C18 cartridges is carried out. Response Surface Methodology has been used for the optimization of the extraction procedure. A matrix effect is observed in olive oil extract; therefore the standard addition method must be used. The detection limit is 19.00 ng g−1 and recoveries for three levels of fortification are ranged from 79.9% to 104.5%.
- Published
- 2006
29. Relación entre los niveles de tacrolimus en sangre y la incidencia de rechazo en enfermos trasplantados de corazón
- Author
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M. Cárdenas Aranzana, M.D. Aumente Rubio, M.D López Malo de Molina, R. Albornoz López, J.M Arizón del Prado, and A.I. Gago Sánchez
- Subjects
Pharmacology ,business.industry ,Medicine ,business ,Humanities - Abstract
Resumen Objetivo Evaluar la relacion entre los niveles en sangre de tacrolimus, la incidencia de rechazo agudo en enfermos trasplantados de corazon y determinar el rango de concentracion mas adecuado para prevenir el rechazo. Estudiar otros factores predictores del rechazo. Metodo Se realizo un estudio retrospectivo de todos los enfermos adultos trasplantados de corazon entre enero de 2000 y octubre de 2003 en tratamiento con tacrolimus, corticoides y azatioprina/ micofenolato mofetil. La eficacia del tratamiento se evaluo por confirmacion histopatologica del rechazo agudo como grado ≥ 3A segun criterios del Sociedad Internacional de Trasplante de Pulmon y Corazon (ISHLT). Se registraron los resultados de las biopsias endomiocardicas y de los niveles minimos de tacrolimus en sangre durante el primer ano postrasplante. El analisis de los datos se realizo mediante la t de Student, regresion logistica univariante y curva ROC. Resultados Se encontraron diferencias significativas en la concentracion minima de tacrolimus en sangre alcanzada el dia +5 postrasplante entre los enfermos que presentaron algun episodio de rechazo agudo el primer ano y los que no (5,76 ± 3,4 vs 9,66 ± 2,73 ng/ml, p = 0,016). El nivel el dia +5 fue el mejor predictor del rechazo (p = 0,05) de modo que el riesgo de un paciente respecto a otro con una unidad menos en el nivel de tacrolimus es 1,58 veces mayor. 8 ng/ml es el nivel con mayor poder de discriminacion (sensibilidad = 75% y especificidad = 72,7%), de modo que alcanzar una concentracion minima en sangre de 8 ng/ml el dia +5 reduce la incidencia de rechazo agudo de 33 a 80% (p = 0,055, p. exacta de Fisher). Conclusiones Alcanzar niveles minimos adecuados de tacrolimus en los primeros dias postrasplante (al menos de 8 ng/ml el dia +5) puede ser crucial para evitar el rechazo agudo en pacientes trasplantados de corazon.
- Published
- 2005
30. Efectividad de una consulta de atención farmacéutica para el control del dolor crónico severo
- Author
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Germán Cerdá-Olmedo, J.C. Valia Vera, A Mínguez Martí, M.D. López Alaracón, V. Mosalve Dolz, and J. De Andrés Ibáñez
- Subjects
Pharmacology - Abstract
Resumen Introduccion Se analiza la efectividad de la consulta de atencion farmaceutica en un programa para el control del dolor cronico severo no maligno de enfermos geriatricos, dividido en fases y realizado en la unidad multidisciplinar de tratamiento del dolor del Consorcio Hospital General Universitario de Valencia. Material y metodos Ciento cincuenta pacientes con indicacion clinica de opioide mayor, fueron incluidos en el tercer escalon de la analgesia de la OMS, por el equipo medico y tras una rigurosa seleccion. La consulta de atencion farmaceutica o fase II, realizo un seguimiento de la escalada de dosis, hasta conseguir la estabilizacion del dolor con ausencia de efectos secundarios, asi como el control en la instauracion del tratamiento cronico posterior. Resultados Al finalizar el programa, el 75% de los pacientes controlaron su dolor, precisando una media de 22,7 dias para ajustar la dosis del opiaceo. La dosis media diaria fue de 22,3 mg y el estrenimiento tratado preventivamente desde el inicio. El 59% de los pacientes recibio tratamiento cronico posterior con parches de fentanilo transdermico de 25 μg/h, un 10% continuo con solucion oral de morfina y un 6% morfina de liberacion controlada. El 25% de los pacientes restantes presento incidencias relevantes, detectadas en la fase de escalada terapeutica, que motivaron la suspension del tratamiento y el alta en la unidad por ineficacia terapeutica. A los 24 meses, el 70% de los pacientes continuaban con la dosis inicial. Conclusiones La efectividad de la consulta queda reflejada al conseguir los objetivos del programa.
- Published
- 2005
31. New strategies of cyclosporine monitoring in heart transplantation
- Author
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E Rodriguez Esteban, M.D. Aumente Rubio, M. Cárdenas Aranzana, J.R González Rodrı́guez, M.D López Malo de Molina, E Romo Penas, A. Lopez Granados, C. Segura Saint-Gerons, M Ruiz Ortiz, I. Munoz Carvajal, M. Concha Ruiz, J.M Arizón del Prado, J.M. Segura Saint-Gerons, and F Vallés Belsué
- Subjects
Heart transplantation ,Transplantation ,medicine.medical_specialty ,business.industry ,Cyclosporine assay ,medicine.medical_treatment ,Group ii ,Mean age ,Surgery ,Pharmacokinetics ,Morning dose ,Anesthesia ,Linear regression ,medicine ,Limited sampling ,business - Abstract
The aim of this study was to evaluate cyclosporine (CyA) absorption profiles in heart transplantation to establish the most adequate monitoring strategy and determine the optimal therapeutic range for AUC0–4 or C2 levels. A total of 22 full pharmacokinetic studies were performed at steady-state in 22 adult heart transplant recipients (18 men, 4 women). Twelve studies were performed during the first month posttransplant (group I), and 10 studies were done after 1 month (group II). In 9 outpatients we performed an abbreviated AUC0–4. The mean age of the patients was 49 ± 15 years (range, 15–72 years), and the mean weight was 70.4 ± 10.8 kg (mean, 54–98 kg). The CyA dosage had been adjusteded to maintain trough levels (C0) in the putative target ranges of 200 to 400 ng/mL in group I and between 100 to 300 ng/mL in group II. Blood samples were drawn prior to and at 0.5, 1, 2, 4, 6, 8, and 12 hours after the morning dose. The CyA blood levels were measured by the AxSYM cyclosporine assay. The AUC was calculated by the trapezoidal rule. Multiple linear regression was done to evaluate the predictive ability of various limited sampling strategies. The C0 correlated poorly, either with the full AUC (r2 = 0.64) or the AUC0–4 (r2 = 0.43), while C2 seemed to be the most accurate single predictor of drug exposure (r2 = 0.92 for AUC0–12; r2 = 0.74 for AUC0–4). For both AUC0–4 and AUC0–12, all 2- or 3-point strategies had r2 values approaching that of the C2 value. In conclusion, C2 is a simple, fast, and accurate value to predict AUC0–4 in routine clinical practice. Its implementation must focus on ensuring the commitment of all unit staff, thus ensuring that patients are sampled on time and minimizing the impact on workload.
- Published
- 2003
32. Clinical pharmacokinetics of tacrolimus in heart transplantation: new strategies of monitoring
- Author
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E Romo Penas, C. Segura Saint-Gerons, E Rodriguez Esteban, M.D. Aumente Rubio, J.M Arizón del Prado, D Mesa Rubio, A. Lopez Granados, M.D López Malo de Molina, M. Cárdenas Aranzana, and J.M. Segura Saint-Gerons
- Subjects
Adult ,Male ,medicine.medical_specialty ,Metabolic Clearance Rate ,medicine.medical_treatment ,Urology ,Cmax ,Azathioprine ,Tacrolimus ,Pharmacokinetics ,Humans ,Medicine ,Heart transplantation ,Transplantation ,medicine.diagnostic_test ,business.industry ,Immunosuppression ,Middle Aged ,Surgery ,Therapeutic drug monitoring ,Area Under Curve ,Heart Transplantation ,Drug Therapy, Combination ,Female ,Drug Monitoring ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
The aim of this study was to investigate the absorption profile of tacrolimus (TAC) in heart transplant patients in order to find the best sampling time to predict the total exposure and to explore the target range for optimal clinical immunosuppression. Twenty-five full pharmacokinetic studies were performed in 22 heart transplant patients (11 men and 7 women) at less than 1 year posttransplant. The immunosuppressive treatment was steroids plus azathioprine or mycophenolate mofetil and TAC. The mean age was 55 years (36–64 years) and the mean weight 70.49 kg (50–111 kg). After three days of receiving the same dose, eight blood samples were collected at 0.5, 1, 2, 4, 6, 8, and 12 hours postmorning dose. TAC concentrations were measured by microparticle enzyme immunoassay (IMx). Area under the concentration-time curve(AUC0–12) was calculated by the trapezoidal rule. Using 0–4 hours TAC blood concentrations, a projected 12 hours AUC (extrapolated AUC0–4) was calculated assuming C0 and C12 were comparable. A high interpatient TAC pharmacokinetics variability that was greater during the absorption phase was observed. A Cmax (30.5 ± 13.8 ng/mL) was reached at 2.3 ± 1.5 h. When target trough levels were achieved (10–20 ng/mL), the mean tacrolimus exposure was 230.6 ± 59.2 ng h/mL (120.14–327.7) (n = 19). Correlation between AUC0–12 and C0 was relatively good (r2 = 0.74). Between individual time points, C4 showed the best correlation (r2 = 0.88). In any case the best strategy to monitor is to obtain the extrapolated AUC0–4 (r2 = 0.98), as a good approach to patients with a poor response to treatment.
- Published
- 2003
33. TIME EVOLUTION OF TOMATO QUALITY PARAMETERS VERSUS STORAGE CONDITIONS
- Author
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M. Contreras, A.R. Fernández-Alba, and M.D. López
- Subjects
media_common.quotation_subject ,Time evolution ,Environmental science ,Quality (business) ,Agricultural engineering ,Horticulture ,media_common - Published
- 2003
34. Spectrophotometric and Adsorptive Stripping Square Wave Voltammetric Determination of Iron in Olive Oils, as Complex with 5,5-Dimethylcyclohexane-1,2,3-trione 1,2-Dioxime 3-Thiosemicarbazone (DCDT)
- Author
-
M.D. López Soto, A. Guiberteau, J. M. Ortiz, and T. Galeano Díaz
- Subjects
Thiosemicarbazones ,Detection limit ,Chromatography ,Stripping (chemistry) ,medicine.diagnostic_test ,Calibration curve ,Chemistry ,Iron ,General Chemistry ,Square wave ,Sensitivity and Specificity ,Absorbance ,Vegetable oil ,Spectrophotometry ,Oximes ,Electrochemistry ,medicine ,Plant Oils ,Adsorption ,General Agricultural and Biological Sciences ,Olive Oil ,Voltammetry - Abstract
Two methods for the determination of iron in olive oil by spectrophotometry and by adsorptive stripping square wave voltammetry (Ad-SSWV) have been developed. These two methods are based on the formation of a 5,5-dimethylcyclohexane-1,2,3-trione 1,2-dioxime 3-thiosemicarbazone (DCDT)-iron(II) complex in strongly acid media. In both, iron is extracted from the olive oil by using HCl. Spectrophotometric determination of iron with DCDT is based on the feature that the DCDT-Fe complex shows an absorbance maximum at 550 nm. A calibration graph has been constructed from 0 to 4000 ng mL(-)(1), and the detection limit was 115 ng mL(-)(1) (57 ng g(-)(1) in olive oil). On the other hand, the voltammetric determination of the metal is based on the appearance of a peak due to an adsorptive reductive process of the complex that it is observed when the Ad-SSWV technique is used. A calibration graph has been constructed from 0 to 30 ng mL(-)(1), and the detection limit was 0.55 ng mL(-)(1) (13.75 ng g(-)(1) in olive oil according to the proposed procedure).
- Published
- 2003
35. The influence of Cr addition on the corrosion resistance of Fe73.5Si13.5B9Nb3Cu1 metallic glass in marine environments
- Author
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A Pardo, E Otero, M.C Merino, M.D López, M Vázquez, and P Agudo
- Subjects
General Chemical Engineering ,General Materials Science ,General Chemistry - Published
- 2002
36. Anticoagulants and Other Preanalytical Factors Interfere in Plasma Nitrate/Nitrite Quantification by the Griess Method
- Author
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David Ricart-Jané, Miquel Llobera, and M.D. López-Tejero
- Subjects
Male ,Cancer Research ,Physiology ,Sodium ,Clinical Biochemistry ,Inorganic chemistry ,chemistry.chemical_element ,Nitrate reductase ,Biochemistry ,Citric Acid ,Absorbance ,chemistry.chemical_compound ,Griess test ,Sulfanilamides ,Sodium citrate ,Animals ,Rats, Wistar ,Nitrite ,Edetic Acid ,Nitrites ,Nitrates ,Aqueous solution ,Chromatography ,Heparin ,Anticoagulants ,Reproducibility of Results ,Free Radical Scavengers ,Ethylenediamines ,Rats ,Ultrafiltration (renal) ,chemistry - Abstract
Nitric oxide (NO) is a signal molecule with functions such as neurotransmission, local vascular relaxation, and anti-inflammation in many physiological and pathological processes. Various factors regulate its intracellular lifetime. Due to its high reactivity in biological systems, it is transformed in the bloodstream into nitrates (NO − 3 ) by oxyhemoglobin. The Griess reaction is a technically simple method (spectrophotometric, 540 nm) for the analysis of nitrites (NO − 2 ) in aqueous solutions. We studied the interference of common anticoagulants in the quantification of nitrate and nitrite in plasma samples by the Griess method. We obtained rat plasma using heparin or sodium EDTA as anticoagulants, then added, or otherwise, known NO − 3 amounts in order to calculate their recovery. We also studied the effect of ultra-filtration performed before Griess reaction on plasma and aqueous solutions of various anticoagulants (heparin, EDTA, and also sodium citrate) to compare the recoveries of added NO − 3 or NO − 2 . We used standards of NO − 3 or NO − 2 for quantification. We conclude that: (i) The bacterial nitrate reductase used to reduce NO − 3 to NO − 2 is unstable in certain storage conditions and interferes with different volumes of plasma used. (ii) The ultrafiltration (which is sometimes performed before the Griess reaction) of plasma obtained with EDTA or citrate is not recommended because it leads to overestimation of NO − 3 . In contrast, ultrafiltration is necessary when heparin is used. (iii) The absorbance at 540 nm attributed to plasma itself (basal value or background) interferes in final quantification, especially when ultrafiltration is not performed. For the quantification of plasma NO − 3 we recommend: sodium EDTA as anticoagulant, no ultrafiltration of plasma, and measurement of the absorbance background of each sample.
- Published
- 2002
37. Detection of interleukin-2 is not useful for distinguishing between latent and active tuberculosis in clinical practice: a prospective cohort study
- Author
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Francesca Sánchez, Ángel Domínguez-Castellano, Jesús Agüero-Balbin, Diego J. Pargada-Ferrer, N. Jové, Elvira Pérez-Escolano, F. Morandeira-Rego, Edu A. Struzka, X. Casas-Garcia, R. Agüero-Balbín, Mónica Ríos, Juan F. Rodríguez-Gutiérrez, A. Gonzalez-Cuevas, A. Coira-Nieto, R. Rabuñal, Fernando Alcaide, Abel Pallarés-Sanmartín, Joan Climent, Miguel Santin, Luis Anibarro, M.D. López-Prieto, Antón Penas-Truque, M. Trigo-Daporta, A. Martinez-Meñaca, María Dolores González-Ripoll Navarro, [Santin, M.] Bellvitge Univ Hosp IDIBELL, Infect Dis Serv, Barcelona 08907, Spain, [Santin, M.] Univ Barcelona, Dept Clin Sci, Barcelona, Spain, [Morandeira-Rego, F.] Bellvitge Univ Hosp IDIBELL, Serv Immunol, Barcelona, Spain, [Alcaide, F.] Bellvitge Univ Hosp IDIBELL, Microbiol Serv, Barcelona, Spain, [Alcaide, F.] Univ Barcelona, Dept Pathol & Expt Therapy, Barcelona, Spain, [Rabunal, R.] Hosp Univ Lucus Augusti, Infect Dis Unit, Lugo, Spain, [Anibarro, L.] Complexo Hosp Univ Pontevedra, Serv Infect Dis Internal Med, Unit TB, Pontevedra, Spain, [Aguero-Balbin, R.] Hosp Univ Marques de Valdecilla, Serv Resp Dis, Santander, Spain, [Martinez-Menaca, A.] Hosp Univ Marques de Valdecilla, Serv Resp Dis, Santander, Spain, [Casas-Garcia, X.] Hosp Gen Parc Sanitari St Joan de Deu, Resp Dis, Barcelona, Spain, [Perez-Escolano, E.] Hosp Jerez, Unidad Gest Clin Enfermedades Infecciosas & Micro, Cadiz, Spain, [Lopez-Prieto, M. D.] Hosp Jerez, Unidad Gest Clin Enfermedades Infecciosas & Micro, Cadiz, Spain, [Navarro, M. D.] Hosp Virgen Macarena, Clin Unit Infect Dis & Prevent Med, Seville, Spain, [Dominguez-Castellano, A.] Hosp Virgen Macarena, Clin Unit Infect Dis & Prevent Med, Seville, Spain, [Sanchez, F.] Hosp del Mar, IMIM, Infect Dis Serv, Barcelona, Spain, [Jove, N.] Hosp del Mar, IMIM, Infect Dis Serv, Barcelona, Spain, [Coira-Nieto, A.] Hosp Univ Lucus Augusti, Microbiol Serv, Lugo, Spain, [Trigo-Daporta, M.] Complexo Hosp Univ Pontevedra, Microbiol Serv, Pontevedra, Spain, [Gonzalez-Cuevas, A.] Hosp Gen Parc Sanitari St Joan de Deu, Microbiol Serv, Barcelona, Spain, and Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (ISCIII) of the Spanish Government
- Subjects
Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,Interleukin 2 ,medicine.medical_specialty ,Tuberculosis ,Cells ,030106 microbiology ,QuantiFERON ,Interferon-gamma ,03 medical and health sciences ,0302 clinical medicine ,Latent Tuberculosis ,Memory ,Interquartile range ,Internal medicine ,medicine ,Humans ,Latent tuberculosis infection ,Interferon gamma ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Tuberculosis, Pulmonary ,Incubation ,Aged ,Latent tuberculosis ,business.industry ,General Medicine ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,Active tuberculosis ,Infectious Diseases ,Spain ,Immunology ,Interleukin-2 ,Female ,business ,Biomarkers ,medicine.drug - Abstract
Previous reports have identified interleukin-2 (IL-2), quantified in the supernatants of QuantiFERONA multicentre study of 161 consecutive adult patients undergoing evaluation for active TB at eight TB Units in Spain. Interferon-γ (IFN-γ) and IL-2 were assessed in the supernatant of QFT after 16-24 h and 72 h of incubation. The accuracy of IL-2 for indicating latent TB infection (LTBI) was assessed by receiving operating characteristic curves. .Twenty-eight participants were not infected, 43 had LTBI, 69 had TB, and 21 were not classifiable. Median (interquartile range) IL-2 concentrations after 72 h of incubation were 0.0 pg/mL (0.0-0.0) in uninfected individuals, 261.0 pg/mL (81.0-853.0) in LTBI individuals, 166.5 pg/mL (33.5-551.5) in patients with extrapulmonary TB, 95.0 pg/mL (26.0-283.0) in patients with smear-negative pulmonary TB, and 38.5 pg/mL (7.5-178.0) in patients with smear-positive pulmonary TB (p0.0001). The area under the curve of the receiving operating characteristic curve (95% CI) of IL-2 after 72 h of incubation for the diagnosis of LTBI was 0.63 (0.53-0.74) when all TB cases were considered as a single group, ranging from 0.59 (0.47-0.71) to 0.72 (0.58-0.85) when only extrapulmonary and smear-positive pulmonary TB cases respectively were considered.Quantification of IL-2 in the supernatant of QFT after a prolonged incubation is not useful to distinguish between LTBI and active disease in clinical practice.
- Published
- 2016
38. First report of a medullar cord compression secondary to osseous plasmacytoma successfully treated with bortezomib and dexamethasone
- Author
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J. Ibáñez, S. Cavero, I. Español, M.D. López, Antonio Martínez, T. Iturbe, M.C. García, A. Tejedor, and C. Funes
- Subjects
musculoskeletal diseases ,Cancer Research ,medicine.medical_specialty ,Cord ,business.industry ,Bortezomib ,medicine.medical_treatment ,Hematology ,musculoskeletal system ,medicine.disease ,Surgery ,Radiation therapy ,Oncology ,immune system diseases ,Spinal cord compression ,hemic and lymphatic diseases ,Medicine ,Plasmacytoma ,business ,Previously treated ,neoplasms ,Dexamethasone ,medicine.drug - Abstract
Medullar cord compression secondary to osseous plasmacytomas affecting the vertebrae is an oncological emergency. A 75-year-old woman with recurrent osseous plasmacytomas and thoracic spinal cord compression, previously treated with radiotherapy, was successfully treated with bortezomib and dexamethasone. Three years later, when the plasmacytoma and spinal cord compression relapsed, she was retreated with the same therapeutic scheme, achieving a new complete clinical remission. This is the first reported case of an excellent response to the combination of bortezomib and dexamethasone for spinal cord compression due to osseous plasmacytoma.
- Published
- 2010
39. MORPHOLOGICAL AND CHEMICAL CAMOUFLAGE OF THE MEDITERRANEAN NUDIBRANCH DISCODORIS INDECORA ON THE SPONGES IRCINIA VARIABILIS AND IRCINIA FASCICULATA
- Author
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Arnaldo Marín, M.D. López Belluga, G. Cimino, and G. Scognamiglio
- Subjects
Mediterranean climate ,Sponge ,Mediterranean sea ,biology ,Botany ,Animal Science and Zoology ,Hepatopancreas ,Nudibranch ,Aquatic Science ,biology.organism_classification ,Mantle (mollusc) ,Tetronic acid ,Mucus - Abstract
The nudibranch Discodoris indecora shows a perfect camouflage on its prey, the dictyoceratid sponge Ircinia variabilis. Shape and colour of the nudibranch are remarkably similar to that of the sponge which is widespread in the shallow waters of the Mediterranean Sea. The metabolite pattern of /. variabilis is dominated by unusual molecules, the sesterterpenoids palinurin and variabilin, containing 25 carbons and displaying at the ends a ^-substituted furan ring and a tetronic acid. However, a chemical polymorphism has been recently described for /. variabilis. Some specimens contain either palinurin or variabilin whereas others possess a mixture of both sestertepenoids. During the study of Mediterranean sponges, a linear sesterterpenoid related to palinurin and variabilin was found in Ircinia fasciculata, that from a taxonomic point of view is closely relatedto Ircinia variabilis. Discodoris indecora shows a typical defence behaviour when it is disturbed, secreting a copious white slime that contains large amounts of palinurin and variabilin. Most likely the animal is able to transfer the sponge metabolites from the digestive glands to mantle glands. Electron micrographs of the nudibranch mantle showed the presence of unicellular glands characterized by a cylindrical vacuole with a big nucleus on the basis. The glands were concentrated in the most conspicuous tubercles of the dorsal mantle. Probably, the sponge metabolites are stored in these glands. Comparative chemical analysis of mucous secretions, dorsal tubercles, mantle, foot, digestive glands and hepatopancreas of D. indecora confirmed this hypothesis. Palinurin and fasciculation were, of course, present in the digestive glands but they were also found in the mucus and in the mantle sections enriched by the above described unicellular glands. The defensive role of palinurin and variabilin, strongly suggested by their anatomical location, was
- Published
- 1997
40. Thirteen cases of liver-kidney transplantation
- Author
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M.R. González, P. Ramirez, M.D. López, Pascual Parrilla, F. Sánchez, P. Cascales, Antonio Ríos, J. Domingo, and Ricardo Robles
- Subjects
Adult ,medicine.medical_specialty ,Liver kidney transplantation ,Adolescent ,Gastroenterology ,Liver disease ,Young Adult ,Internal medicine ,medicine ,Humans ,Transplantation ,Kidney ,urogenital system ,business.industry ,Liver and kidney ,Liver Diseases ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Surgery ,Liver Transplantation ,Survival Rate ,medicine.anatomical_structure ,Kidney Failure, Chronic ,business ,Polyneuropathy - Abstract
Combined kidney-liver transplantation is currently the best therapeutic option for patients with end-stage kidney and liver disease. We present our experience of kidney-liver transplantation in a series of 13 patients. The most frequent indications were familial amyloidotic polyneuropathy (FAP) and polycystosis of the liver and kidney. The 1- and 5-year survival rates of the liver grafts were 75% and 67%, respectively, with no kidney losses during follow-up.
- Published
- 2010
41. Automatically Modeling Linguistic Categories in Spanish
- Author
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M.D. López De Luise, M. Soffer, and Débora Hisgen
- Subjects
Sequence ,Computer science ,Process (engineering) ,Metric (mathematics) ,Robot ,A-weighting ,Sentence ,Linguistics ,Word (computer architecture) - Abstract
This paper presents an approach to process Spanish linguistic categories automatically. The approach is based in a module of a prototype named WIH (Word Intelligent Handler), which is a project to develop a conversational bot. It basically learns category usage sequence in a sentence. It extracts a weighting metric to discriminate most common structures in real dialogs. Such a metric is important to define the preferred organization to be used by the robot to build an answer.
- Published
- 2010
42. Contents, Vol. 61, 1992
- Author
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M.P Garrón, Ja-Liang Lin, Hiroaki Kiyokawa, C. Abarca-Franco, A. Di Benedetto, C. Schmalisch, A. Ortiz, Hiromu Nakajima, L. Velásquez-Jones, Makoto Nakamura, Mark B. Thomas, Annibale D’Annibale, A. Galera, P. Padovese, González Parra, J. Egido, G. Scibelli, Hiroshi Yamakawa, Takao Saruta, M. García-Fuentesa, Michio Suda, C. Costagliola, Philippe Lelarge, A.H. Tzamaloukas, Jean-Philippe Méry, Gilberto Calconi, P. Sorice, Hiromichi Suzuki, Masatoshi Fujishima, Andrew St John, A. de Vincentiis, Toru Oka, L. Valencia-Espinoza, Mark T. Houser, Maria Cristina Maresca, Takashi Sakurai, C. Minoia, Bernard F. Jones, Sabine Kenouch, P.W. de Leeuw, Paul Trevillian, M. Schostak, Seiya Okuda, Helmut Graf, Shinichi Nishi, R.A. Feelders, A. Berlin, Kiyoshi Tamaki, Hirofumi Makino, Ikuo Mineo, H.C. Fischer, Philippe R. Bauer, Sumio Takahashi, Emmanuel Oluyemi Agbedana, Hiroshi Hasegawa, L. Romano, Brian Hutchison, G. Vreugdenhil, Robert A.P. Koene, P. Kolevski, A. Vianello, M. Polenaković, Pratap S. Avasthi, Lambert H, K. Markakis, Ian Dick, Giordano Chiara, Seiichiro Tarui, Giannantonio Arrigoni, M.D. López, Yuji Moriwaki, Sidney J. Stohs, Takeo Goto, Kazuya Higashino, Agatha van der Schaff, Richard L. Prince, Shozo Miki, Robert H.K. Mak, Norio Kono, Alain Larcan, Gabriele Bertolone, Takao Shimizu, J.A. Quiroga, Eric F.C. Wong, K.U. Eckardt, D. Brancaccio, Masanori Kawachi, Naoya Igaki, Shu H. Wei, Gianpaolo Amici, P. Valencia-Mayoral, Lionel Nace, M. Arias, R. Muñoz-Arizpe, Norman L.M. Wong, Pierre-Edouard Bollaert, Peter C. Kolbeck, Yutaka Kouda, P.J.W. Coppens, R. Pietra, Shuji Ikeda, J.C. Porres, D. Kampf, V. Carreño, Shiro Yorifuji, Lawrence S. Milner, E. Marriott, S. Fortaner, Toshinori Haramoto, Hidetoshi Kanai, E. Sabbioni, Brian Mullan, M. Gallieni, L. Grčevska, Charmian P. Davies, J.L. Alvarez-Granda, Kaoru Onoyama, B. Ehmer, Maurizio Mordacchini, Yoshihei Hirasawa, Tetsuya Yamamoto, J. Gamboa-Marrufo, D. Stavrić, J. Jiménez, C. Caramelo, Ralph A. De Fronzo, Shigel Miyazaki, Zensuke Ota, and Masamichi Kuwajima
- Subjects
Traditional medicine ,business.industry ,Medicine ,business - Published
- 1992
43. Adenoma de paratiroides en la edad preescolar
- Author
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M.I. Valenzuela Serrano, E. García García, M.D. López Moreno, and J.P. López Siguero
- Subjects
endocrine system diseases ,Hyperparathyroidism ,Pediatrics, Perinatology and Child Health ,Hypercalcemia ,Child ,Pediatrics ,RJ1-570 ,Parathyroid neoplasms - Abstract
El hiperparatiroidismo primario es una entidad rara en la infancia. La forma neonatal se produce por hiperplasia de las glándulas paratiroides. En el resto de edades pediátricas las formas esporádicas se deben principalmente a adenomas y las familiares a hiperplasia. Los adenomas se presentan generalmente en adolescentes. En el caso que se describe, un adenoma de paratiroides fue extirpado en una niña de 11 años con antecedente de hipercalcemia esporádica desde los 5,5 años de edad, descubierta en una analítica y sin presentar síntomas ni complicaciones debidas a ella. Los estudios de imagen preoperatorios, entre ellos la gammagrafía con 99mTc-sestabimi, localizaron la lesión y la intervención normalizó la calcemia. El adenoma de paratiroides se presenta también en la edad preescolar y su diagóstico puede demorarse por la ausencia de síntomas. : Primary hyperparathyroidism in children is rare. The neonatal form involves hyperplasia of the parathyroid glands. In older children sporadic forms are usually due to an adenoma and familial forms are generally due to hyperplasia. Adenoma usually presents in adolescents. In the case presented herein, a parathyroid adenoma was excised from an 11-year-old girl with a history of sporadic hypercalcemia from the age of 5.5 years. The disease was discovered in serum chemistry and the patient presented no symptoms or conditions associated with hypercalcemia. Diagnosis was by preoperative imaging studies including 99mTc-sestabimi and surgical intervention stabilized calcium levels. Parathyroid adenoma occurs in pre-school age children and its diagnosis may be delayed because of the absence of symptoms.
- Published
- 2000
44. Improved Induction Tree Training for Automatic Lexical Categorization
- Author
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M. Soffer, M.D. López De Luise, and F. Spelanzon
- Subjects
Parsing ,Computer science ,business.industry ,Training (meteorology) ,computer.software_genre ,Tree (data structure) ,TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES ,Categorization ,Artificial intelligence ,business ,computer ,Natural language processing ,Word (computer architecture) ,Sentence - Abstract
This paper studies a tuned version of an induction tree which is used for automatic detection of lexical word category. The database used to train the tree has several fields to describe Spanish words morpho-syntactically. All the processing is performed using only the information of the word and its actual sentence. It will be shown here that this kind of induction is good enough to perform the linguistic categorization.
- Published
- 2009
45. 913 SPANISH CONSENSUS GUIDE FOR THE TREATMENT OF SEVERE REFRACTORY SPASTICITY WITH INTRATHECAL BACLOFEN
- Author
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J.M. Lopez‐Millan Infantes, G. Cerdá Olmedo, M.L. Franco Gay, J. Insausti, M.D. López Alarcón, S. Moliner Velázquez, V. Monsalve Dolz, J. Pérez Cajaraville, M. Tió Felip, and E. Uriarte
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Refractory ,business.industry ,Anesthesia ,Physical therapy ,Medicine ,Spasticity ,medicine.symptom ,business ,Intrathecal baclofen - Published
- 2009
46. Non-Technological Aspects on Web Searching Success
- Author
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M.D. López De Luise and Juan María Ale
- Subjects
Web standards ,Bayes' theorem ,Information retrieval ,C4.5 algorithm ,Computer science ,Process (engineering) ,media_common.quotation_subject ,Personality ,Cluster analysis ,Correspondence analysis ,Category utility ,media_common - Abstract
This paper studies the influence of social, cultural and emotional background of typical Web users into the web searching process. Several variables, describing such aspects, are represented and statistically analyzed with well known clustering and classifying algorithms such, as COBWEB, J48, Bayes classification, and Correspondence analysis. Results indicate that the efficiency of the complete process of Information Retrieval will not be fully understood without considering subjectivity and personality facts.
- Published
- 2008
47. Ambiguity and Contradiction From a Morpho-Syntactic Prototype Perspective
- Author
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M.D. López De Luise
- Subjects
biology ,Process (engineering) ,Computer science ,media_common.quotation_subject ,Perspective (graphical) ,Lexical ambiguity ,Contradiction ,Morpho ,Ambiguity ,biology.organism_classification ,Linguistics ,media_common - Abstract
In this paper, the contradiction and ambiguity problems in Natural language Processing are briefly introduced. We also present the morpho-syntactic WIH (Web Intelligent Handler) prototype and the overall approach it takes to process any Spanish text. Finally, we analyze how it processes Spanish sentences with contradictions or ambiguities using its own perspective, despite deeper linguistic considerations.
- Published
- 2008
48. A Metric for Automatic Word categorization
- Author
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M.D. López De Luise
- Subjects
Discriminator ,Computer science ,business.industry ,Part of speech ,computer.software_genre ,Text processing ,Categorization ,Statistical analyses ,Metric (mathematics) ,Artificial intelligence ,Computational linguistics ,business ,computer ,Word (computer architecture) ,Natural language processing - Abstract
This paper presents a metric to be used by the working prototype WIH (Web Intelligent Handler). This metric (referred here as po) is designed to reflect main topic words and discriminate certain text profiles through word weightings. The actual version is designed only for Spanish web texts. Statistical analyses show that it is possible to differentiate text profiles upon po behavior. A poll is presented also, showing that it is a good main words discriminator. This paper is posted here as a new algorithm useful for Spanish text processing.
- Published
- 2008
49. Determination of fenthion and fenthion-sulfoxide, in olive oil and in river water, by square-wave adsorptive-stripping voltammetry
- Author
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T. Galeano Díaz, A. Guiberteau Cabanillas, M.D. López Soto, and J. M. Ortiz
- Subjects
Acetonitriles ,Metabolite ,chemistry.chemical_element ,Fresh Water ,Chemistry Techniques, Analytical ,Analytical Chemistry ,chemistry.chemical_compound ,Rivers ,Safrole ,Adsorptive stripping voltammetry ,Electrochemistry ,Plant Oils ,Solid phase extraction ,Voltammetry ,Olive Oil ,Detection limit ,Chromatography ,Fenthion ,Chemistry ,Pesticide Residues ,Water ,Dropping mercury electrode ,Hydrogen-Ion Concentration ,Mercury (element) ,Calibration ,Adsorption ,Food Analysis - Abstract
Square-wave adsorptive-stripping voltammetry technique has been used to develop a method for the determination of fenthion in olive oil. Due to the fact that fenthion does not give any electrochemical signal at mercury electrode, the method has been based on a previous oxidation of fenthion to its metabolite, fenthion-sulfoxide, by using KMnO 4 . The metabolite gives rise to a peak due to an adsorptive-reductive process at −0.786 V. Fenthion is isolated from olive oil by carrying out a solid–liquid extraction procedure using silica cartridge, followed by a liquid–liquid partitioning with acetonitrile. The detection limit in olive oil is 78.8 ng g −1 and recoveries for four levels of fortification are ranged from 85% to 109%. On the other hand, it has been developed a method for the simultaneous determination of fenthion and its metabolite fenthion-sulfoxide, in river water. Pesticides are isolated from water by carrying out a liquid–liquid partitioning with trichloromethane. The detection limits are 0.41 ng g −1 and 0.44 ng g −1 , for fenthion and fenthion-sulfoxide, respectively. Recoveries for three levels of fortification are ranged from 96% to 103% for fenthion and 94% to 104% for fenthion-sulfoxide.
- Published
- 2007
50. PP110-SUN CONCOMITANT APOLIPOPROTEIN A-IV AND CITRULLINE PLASMA CHANGES IN CHRONIC SHORT BOWEL SYNDROME PATIENTS
- Author
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J. Ruiz, M.N. Virgili, D. Oró, A.M. Pita, M.D. López-Tejero, N. Garcia, and G. Creus
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Medicine (miscellaneous) ,Apolipoprotein A-IV ,Critical Care and Intensive Care Medicine ,Short bowel syndrome ,medicine.disease ,Gastroenterology ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Concomitant ,medicine ,Citrulline ,business - Published
- 2012
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