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ObjectivesSurgeons become uncomfortable while performing surgery because heat transfer and evaporative cooling are restricted by insulating surgical gowns. Consequently, perceptions of thermal discomfort during surgery may impair cognitive performance. We, therefore, aimed to evaluate surgeons’ thermal comfort, cognitive performance, core and mean skin temperatures, perceptions of sweat-soaked clothing, fatigue and exertion with and without a CoolSource cooling vest (Cardinal Health, Dublin, Ohio, USA).MethodsThirty orthopaedic surgeons participated in a randomised cross-over trial, each performing four total-joint arthroplasties with randomisation to one of four treatment sequences. The effects of cooling versus no cooling were measured using a repeated-measures linear model accounting for within-subject correlations.ResultsThe cooling vest improved thermal comfort by a mean (95% CI) of −2.1 (–2.7 to –1.6) points on a 0–10 scale, pConclusionsA cooling vest worn during surgery lowered core and skin temperatures, improved thermal comfort, and decreased perceptions of sweating and fatigue, but did not improve cognition. Thermal discomfort during major orthopaedic surgery is thus largely preventable, but cooling does not affect cognition.Trial registration numberNCT04511208.

Background: The self-administered iPad-based Cleveland Clinic Cognitive Battery (C3B) was designed specifically for the efficient screening of cognitive functioning of older adults in a primary care setting. Objective: 1) Generate regression-based norms from healthy participants to enable demographic corrections to facilitate clinical interpretation; 2) estimate test-retest reliability and practice effects; 3) examine ability to discriminate mild cognitive impairment (MCI) from healthy aging; 4) d etermine validity of screening in a distracting clinical environment; and 5) determine completion rates and patient satisfaction in a primary care setting. Methods: Study 1 (S1) recruited a stratified sample of 428 healthy adults, ages 18–89, to generate regression-based equations. S2 assessed 2-week test-retest reliability and practice effects in 30 healthy elders. S3 recruited 30 MCI patients and 30 demographically-matched healthy controls. In S4, 30 healthy elders self-administered the C3B in a distracting environment and in a quiet private room in counterbalanced order. In a demonstration project, 470 consecutive primary care patients were administered the C3B as part of routine clinical care (S5). Results: C3B performance was primarily influenced by age, education, and race (S1), had acceptably high test-retest reliability and minimal practice effects (S2), discriminated MCI from healthy controls (S3), was not negatively impacted by a distracting clinical environment (S4), had high completion rates (>92%) and positive ratings from primary care patients (S5). Conclusion: The C3B is a computerized cognitive screening tool that is reliable, validated, self-administered, and is conducive to integration into a busy primary care clinical workflow for detecting MCI, early Alzheimer’s disease, and other related dementias.

The neotropical savannas of Eastern Colombia (Llanos) are subjected to changes in land use associated with intensification of beef production and there is limited knowledge on the long-term impacts of these change processes. Furthermore, the effects of spatial and temporal intensification at farm level via the introduction of sown pastures on beef herd outputs, their greenhouse gas (GHG) emissions and the resulting carbon (C) footprints in contrasting savanna landscapes of of the Llanos are unknown. This study was aimed to assess the consequences of gradual system intensification via introduction of sown tropical pastures in two contrasting landscapes, the tillable, flat savannas and the highly dissected rangelands, of the well-drained Eastern savannas of Colombia, in terms of cow-calf production and GHG emissions and the resulting C footprints. A dynamic model was developed to simulate the gradual introduction of two types of tropical pastures in a region with dissected and steep slopes and limited tillable areas where cattle would also have access to Serrania savanna and sown pastures, versus one located in the Plains that are fully transformed over time with the exclusion of native rangelands. Marked changes in herd demography, animal outputs, and emissions were found over time. The C footprint of all systems varied over time depending upon the length of time that pastures contributed to soil organic carbon accumulation and the balance between savanna and sown pasture areas at a whole farm level. In conclusion, the dynamics of the systems subject to intensification were marked and were dependent on the temporal and spatial deployment of sown forage resources. Therefore, generalizing the trends for the region as a whole result in uncertainty. Nevertheless, examination of simulated prototypes may shed light on the expected trends and provides guidance for decision-making

Neotropical savannas of the Colombian Orinoquia are largely dedicated to year-round beef production. There is evidence of sustainable animal production in this savanna environment, but little is known of the links among animal lifetime performance, greenhouse gas emissions, and soil organic carbon (SOC) accumulation at the system level. The main objective of this study was to estimate C footprint of beef production from Brahman (Bos indicus) cull cows finished on contrasting C4-grass-based pastures in the Orinoco basin. Long-term individual variations of liveweights and reproductive performance were used in an Excel® dynamic model to estimate dry matter intake, methane (CH4) emissions and carcass traits, and C footprint at the farm gate. Values from the developed database were computed for cows born and raised on the savanna, bred on Brachiaria decumbens, and later finished on B. humidicola [Scenario (SCE) 1, SCE 2]; B. decumbens (SCE 3); Andropogon gayanus + Melinis minutiflora + Stylosanthes capitata (SCE 4); and A. gayanus + S. capitata (SCE 5) pastures. We estimated C footprints of SCE 1, SCE 3, and SCE 5 using published values of the rates of emission of CH4 and nitrous oxide from the soil, feces, and urine; and accumulation of SOC in soil during the fattening period. The majority of the estimated overall C footprint values at the system level were negative due to expected net SOC accumulation during the fattening period. Depending on the expected quality of management, systems ranged from near equilibrium in C balance to net increases in SOC accumulation.

Environmentally friendly materials are being explored as alternatives to lime and cement binders in ground improvement. Biological treatment methods are environmentally friendly as they rely on the natural activity of ubiquitous microbes to produce extracellular polymeric saccharides (EPS) and calcite cements. EPS extruded by microbes exhibit strong adhesion from growth of fibrous bridges and bonds between surfaces. In situ polysaccharide secretion in soils to improve their engineering properties has not been examined. In this study, pulverised dried cattle manure (CM) are is used for in situ EPS production in a synthetic soft soil specimen. The indigenous facultative anaerobes and aerobes in animal waste produce negatively charged EPS molecules in the soil specimen. Bridging of sand particles and embedment of CM fibres in kaolinite aggregates caused an immediate increase in unconfined compressive strength (UCS) of the stabilised specimen. EPS cementation improved soil strength by filling pores and engulfing kaolinite aggregates into bonded mass. Fibre reinforcement and bio-stabilisation by CM increased the UCS of the soil by 740%. Replacing C-intensive lime/cement binders by CM as a stabilising agent has the potential to prevent release of 1 t of carbon dioxide to the atmosphere per tonne of lime/cement consumed.

OBJECTIVE Bertolotti syndrome is a clinical diagnosis given to patients with low-back pain arising from a lumbosacral transitional vertebra (LSTV). While biomechanical studies have demonstrated abnormal torques and range of motion occurring at and above this type of LSTV, the long-term effects of these biomechanical changes on the LSTV adjacent segments are not well understood. This study examined degenerative changes at segments superjacent to the LSTV in patients with Bertolotti syndrome. METHODS This study involved a retrospective comparison of patients between 2010 and 2020 with an LSTV and chronic back pain (Bertolotti syndrome) and control patients with chronic back pain with no LSTV. The presence of an LSTV was confirmed on imaging, and the caudal-most mobile segment above the LSTV was assessed for degenerative changes. Degenerative changes were assessed by grading the intervertebral disc, facets, degree of spinal stenosis, and spondylolisthesis using well documented grading systems. All computations were performed in R, version 4.1.0. All tests were two-sided, and p values < 0.05 was considered statistically significant. Separate logistic regression analyses were run with the associated dependent variables for each aim, with age at MRI and sex included as covariates. Odds ratios and 95% confidence intervals were computed. RESULTS A total of 172 patients were included, 101 with Bertolotti syndrome and 71 controls. Control patients consisted of patients with low-back pain but no diagnosis of Bertolotti syndrome or an LSTV. Fifty-six Bertolotti (55.4%) and 27 control (38.0%) patients were female, (p = 0.03). After adjusting for age at MRI and sex, Bertolotti patients had pelvic incidence (PI) that was 9.83° greater than control patients (95% CI 5.15°–14.50°, p < 0.001). Sacral slope was not significantly different between the Bertolotti and control groups (beta estimate 3.10°, 95% CI −1.07° to 7.27°; p = 0.14). Bertolotti patients had 2.69 times higher odds of having a high disc grade at L4–5 (3–4 vs 0–2), compared with control patients (OR 2.69, 95% CI 1.28–5.90; p = 0.01). There were no significant differences between Bertolotti patients and controls for spondylolisthesis, facet grade, or spinal stenosis grade. CONCLUSIONS Patients with Bertolotti syndrome had a significantly higher PI and were more likely to have adjacent-segment disease (ASD; L4–5) compared with control patients. However, after controlling for age and sex, PI and ASD did not appear to have a significant association within the cohort of Bertolotti patients. The altered biomechanics and kinematics in this condition may be a causative factor in this degeneration, although proof of causation is not possible in this study. This association may warrant closer follow-up protocols for patients being treated for Bertolotti syndrome, but further prospective studies are needed to establish if radiographic parameters can serve as an indicator for biomechanical alterations in vivo.

To properly maintain our public infrastructure, engineers and designers must learn different methods of inspection. An exhaustive review has been carried out for different aspects of non- destructive testing (NDT) adopted for RCC structures. NDT evaluates the remaining operation life of different components of structure. It provides an accurate diagnosis which allows prediction of extended life operation beyond the designed life. Different aspects are considered which includes condition assessment, durability, corrosion, condition ranking and service life of structures. In this review, several non-destructive inspection methods are evaluated, with the aim of identifying those, which are practical for detecting defects at early in the production sequence as possible. The methods used for carrying out non destructive analysis used by different investigators are also discussed. Merits and demerits of each method are also stated. RCC structures considered are reinforced buildings, bridges, ESRs, recently developed NDT techniques which are useful for prediction of performance of structure are also included.

A uniform and elastic SEI was constructed by in situ electro-polymerization of functionalized ionic liquid electrolyte to passivate the electrode surface, thus making potassium or lithium based batteries exhibit excellent electrochemical performance.

Photo-chargeable supercapacitor from a ZnO and V2O5 layered structure under UV illumination.

Electrolytes are critical for the safety and long-term cyclability of potassium ion batteries. Here, a low-concentration, non-flammable, and weakly solvating electrolyte enables the cycling stability of K||graphite cell for over 2 years.

Large scale surface coal mining activities result in disturbance of the local ecosystem by creating different land uses that alter soil properties and hydrological balance of the mining area and surrounding environment. This study aims to evaluate the changes in soil properties in mining affected lands (mine face topsoil, wasteland and agriculture land) and reclaimed mine soil (RMS), and to quantify the changes of the selected soil properties with respect to reference Sal forest (Shorearobusta Gaertn. F.). Changes in soil properties were analyzed on a profile basis (0–20, 20–40 and 40–60 cm). The study indicates that soil pH, electrical conductivity, and bulk density were increased significantly, while a decrease in nutrient content (N, P, and K) was observed in the mining affected lands. The overall findings of this study indicated that conversion of Sal forest into other land uses due to mining significantly reduced the nutrient content and soil quality of the area. Reclamation of the mine degraded land in short duration does not restore the overall properties of the soils, which has long term impacts on the surrounding ecosystem.

Introduction and Aim: T2DM being a most prevalent metabolic disorder globally and is mainly triggered by two important factors: decreased insulin secretion by pancreatic beta-cells and the defective insulin-sensitivity of tissues. Recent studies found that other factors influence insulin release are amino acids, fatty acids, incretins, certain neurotransmitters, and some of the pituitary hormones. Higher levels of peripheral serotonin in diabetic people have drawn attention to the involvement of metabolic homeostasis and cellular sensors. Thus, the aim of this study is to screen the association of tryptophan, serotonin, and insulin in T2DM. Materials and Methods: Serum samples from T2DM patients (n=80) were divided into 2 groups depending on HbA1C levels having good to moderate (6.5-8) and poor (>8) glycemic control to study the levels of tryptophan, serotonin, and insulin. Results: A boarderline statistically significant increase was observed in Serotonin levels in group 2 when compared with group 1. Statistical analysis showed a negative correlation between insulin and serotonin in group 1, whereas in group 2 a negative correlation has observed between HbA1C and insulin. Conclusion: The study report shows an increase in serum serotonin levels with increase in insulin levels and hyperglycemia.

Gut is not only of digestive but also of immunological importance because of the residing microbiota milieu. Pathological or certain therapeutic condition may modify the normal commensal microflora. Mucositis, the most common untoward effect of chemotherapy, can also lead to this microbiotic imbalance. This shift leads to various molecular cascades which in turn trigger the action of Pattern Recognition Receptors (PRR’s). Toll like receptor (TLR) is one such pattern recognition receptor. In the human body there are about 13 types of TLRs out of which TLR-2, TLR-4, TLR-5 and TLR-9 are intestinal specific. They respond through ligands such as bacterial derivatives like flagellin, Lipoteichoic acid, Lipopolysaccharides, microbial antigen or genetic material of the viru. In turn via adaptor molecules, TLRs alter the signalling mechanisms and further induct the activation of pro or anti-inflammatory cytokines based on the immunological need. Several of the studies have described the involvement of under twined mechanisms of TLRs during chemotherapy. Therefore, agonists and/or antagonists of these strategic molecules may play a key role in pathological and therapeutic aspects. Thus, this review is an attempt to focus on the involvement of TLRs and microbiota to different chemotherapeutic agents and thereby track the available mechanisms of functionality.

Reactive oxygen species (ROS) are free radical molecules obtained from biotransformation of molecular oxygen. Oxidative stress is referred as oxidative damage produced by free radicals, and has been associated with many diseases including periodontitis. Periodontitis is a chronic inflammatory disease resulting in loss of attachment and bone loss. There is over production of ROS in periodontitis, imbalance between free radicals and antioxidants locally result in destruction of periodontal tissues. Flavonoids are naturally occurring compounds known for various actions, such as, anti-inflammatory, antioxidant properties. The objective of this review is to provide an outline on the biological actions of flavonoids and their beneficial effects on periodontal tissues.

Menopause is an age-related naturally occurring phenomenon in women. Women generally attain menopause between the 40-58 years of age, during which they undergo several physiological changes that have an impact on their daily activities. The deficiency of B vitamins occurs mainly due to the dietary pattern, absorption and blood loss which may leads to health problems such as cognitive decline, osteoporosis, physical and mental imbalance. This review evaluated the published evidence on the vitamin B status and its impact in post-menopausal women. Selected data sources were searched for relevant literature (2010-2020) and included as per the set criteria using Prisma guidelines. The NIH quality questionnaire tool was used to rate the articles. Finally eleven articles were included for full length review having reports on the impact of B vitamins on bone loss, cognitive decline and physical activity. Existing evidences show that there is no association between B vitamins and bone loss. Very few studies are available which concluded association of B vitamin with cognitive decline and physical health. More studies are required to address this research gap.

Interprosthetic femur fractures (IFFs) are rare, but the treatment is challenging. Currently, there are many treatment methods used in practice, but an updated systematic review of comparison of common different surgical outcomes has not been thoroughly inspected.A systematic review of retrospective studies was conducted. The resource databases of PubMed, Cochrane, and Embase were searched using a combination of the keywords involving IFFs and surgical outcomes from inception through June 2021. Data collected included patient demographics, intraoperative data, and postoperative outcomes. Outcomes were measured based on healing time, revision rate, complication rate, and functional scores.Forty studies were included for review with a total of 508 patients. Average reported age of patients was 78.7 years old and 403 (79.3%) were females. Overall union rate was 74.0% with 376 of 508 patients achieving fracture union after primary treatment of IFF. Only 271 patients had reported healing times of fractures with a mean of 5.15 months. The plate, prosthetic revision, nail/rod, and external fixator groups had mean healing times of 4.69, 8.73, 6.5, and 5.1 months, respectively. Revision rates were highest in the femur replacement treatment group with 9 (32.1%) patients needing at least one reoperation surgery for any reason. Overall, hardware failure and non-unions were the most reported complications in treatment of IFFs. Postoperative functional outcome scores were available for 242 patients. Harris Hip Scores for the plate, revision, replacement, nail/rod, and plate + revision groups were 76.84, 77.14, 69.9, 77, and 78.4, respectively.Each treatment method should be carefully considered by the surgeon depending on the patient. Locking plate was the most common method for the treatment of the patients with IFFs. Half of them combined with cerclage wires/cables. Around two thirds' patients could achieve union with the fastest mean healing time around 4.69 months. Other less common methods included prosthetic revision, femur replacement, nail/rod, external fixator, etc. A small number of patients treated with Ilizarov external fixator, and it has proven to be a viable option with few complications and high union rates.

The granularity and structure of the International Council for Harmonisation’s (ICH) Medical Dictionary for Regulatory Activities (MedDRA) are useful for precise coding of adverse events (AEs) for data analysis. In product labeling for healthcare practitioners, however, the granularity of MedDRA Preferred Terms (PTs) can obscure the communication of adverse reactions (ARs). Driven by a focus on patient safety, business needs, and regulatory guidance, many sponsors and regulators have begun to develop institution-specific approaches to clustering similar AR terms in medical product prescribing information on a product-by-product basis. However, there are no agreed upon conventions that describe which AR terms may be appropriate to group together. In order to improve safety communication to patients and healthcare providers, there is an urgent need for a harmonized international approach to the creation and use of groups of MedDRA PTs which we refer to as “MedDRA Labeling Groupings (MLGs)” in medical product prescribing information. Given its long-standing contributions towards the design of Standardised MedDRA Queries (SMQs), the Council for International Organizations of Medical Sciences (CIOMS) convened an Expert Working Group (EWG) with involvement of multiple major stakeholders to produce a consensus document on principles and points to consider in the development of MLGs. The CIOMS MLG EWG identified variations in grouping of MedDRA PTs in product labels, and in the current document, proposes a strategy for improving the communication of drug safety labeling. It is envisaged that the use of these consensus recommendations would be voluntary and applied to product labels in a manner that is consistent with existing regulatory frameworks.

Background: In 2019, diabetes was the direct cause of 1.5 million deaths. DM (DM), long considered a disease of minor significance to world health, is taking its place as one of the main threats to human health in the 21st century [1]. It is the most common non-communicable disease worldwide and the fifth leading cause of death in developed countries. It has been estimated that by the year 2025, India will have the largest number of diabetic subjects in the world. Objectives: To study the prevalence of macrovascular and microvascular complications in newly diagnosed T2DM patients. Methods: The study is a clinical, cross-sectional study of 180 newly detected type 2 diabetics attending medicine department outpatient/ inpatient, Dr. B. R. Ambedkar Medical College, Kadugondanahalli, and Bangalore from November 2020 to May 2022(18 months) who matched the inclusion criteria. Results: In this, 84 were males and 66 were females. The prevalence of macrovascular complications CAD, and PVD was 17.0% and 8.0% respectively and microvascular complications of retinopathy, nephropathy, and neuropathy were 21.0%, 17.0%, and 22.0% respectively. Conclusion: There is a high prevalence of neuropathy and retinopathy at the time of diagnosis. HbA1c levels predict the prevalence of complications. Screening for neuropathy, retinopathy, and nephropathy at diagnosis is statistically significant. Screening with simple tests at diagnosis for all cases of diabetes is essential to identify the complications at an early reversible stage.

Introduction Repetitive exposure to blast overpressure waves can be a part of routine military and law enforcement training. However, our understanding of the effects of that repetitive exposure on human neurophysiology remains limited. To link an individual’s cumulative exposure with their neurophysiological effects, overpressure dosimetry needs to be concurrently collected with relevant physiological signals. Eye tracking has shown promise for providing insight into neurophysiological change because of neural injury, but video-based technology limits usage to a laboratory or clinic. In the present work, we show capability for using electrooculography-based eye tracking to enable physiological assessment in the field during activities involved repetitive blast exposures. Materials and Methods Overpressure dosimetry was accomplished by using a body-worn measurement system that captures continuous sound pressure levels as well as pressure waveforms of blast event in the range of 135-185 dB peak (0.1-36 kPa). Electrooculography eye tracking was performed using a commercial Shimmer Sensing system, which captured horizontal eye movements of both the left and right eyes, as well as vertical eye movements of the right eye, from which blinks can also be extracted. Data were collected during breaching activities that included repetitive use of explosives. Participants in the study were U.S. Army Special Operators and Federal Bureau of Investigations special agents. Approval for research was received by the Massachucetts Institute of Technology Committee on the Use of Humans as Experimental Subjects, the Air Force Human Research Protections Office, and the Federal Bureau of Investigations Institutional Review Board. Results The energy from overpressure events was accumulated and summarized into an 8-hour equivalent of sound pressure level (i.e., LZeq8hr). The total exposure in a single day, i.e., the LZeq8hr, ranged from 110 to 160 dB. Oculomotor features, such as blink and saccade rate, as well as variance in blink waveforms, show changes across the period of overpressure exposure. However, the features that showed significant change across the population were not necessarily the ones that showed significant correlation with the levels of overpressure exposure. A regression model built to predict overpressure levels from oculomotor features alone showed a significant association (R = 0.51, P Conclusions This study successfully demonstrated that eye tracking can be performed during training activities, such as explosive breaching, and that the modality may provide insight into neurophysiological change across periods of overpressure exposure. The results presented herein show that electrooculography-based eye tracking may be a useful method of assessing individualized physiological effects of overpressure exposure in the field. Future work is focused on time-dependent modeling to assess continuous changes in eye movements as this will enable building dose–response curves.

The world is facing a very big issue related to the presence in high proportion of very contaminated substance like copper as well as lead in the water, which can lead to health problems too. An existence of those metal ions in higher concentration may cause severe health problems to human beings and animals. The heavy metal should be extracted from the water which is very much toxic in nature, the method for this should be cost-effective and maintain the safety as well. In this perspective, the scholars across the globe are working on the economical invention for this serious problem. The discovery of the agro-based adsorbent material is highly demanding and the possibility of these material for removal of the toxic material present in the water. It is well known that the adsorption procedure is suitable for different water types and make possible of the removal of heavy metal ions, i.e. HM ions. The present work is related to solve this problem using Powdered Groundnut Husk, which is obtained from easy available agricultural by-products like Powdered Groundnut Husk (PGH) and Powder Activated Carbon (PAC). The batch mode method is used for the extraction of the Cu from the solution which is aqueous in nature. The properties of the pH solution on the efficiency of the removing of heavy metals using PGH and PAC have been investigated in the present work.

The formation of uranyl phosphate precipitates is a remediation strategy to limit the mobility of uranium in contaminated soils. However, exposure to organic ligands, like the plant exudate citrate, can remobilize the uranium. The purpose of this study is to provide a more thorough comprehension of citrate-promoted dissolution of a uranyl phosphate mineral, chernikovite [(H3O)(UO2)(PO4)•3H2O], by determining the extent of uranium release from chernikovite at a wide range of citrate concentrations. We have quantified the kinetics of dissolution and proposed potential mechanisms of chernikovite dissolution to gain a better understanding of the fate of uranyl phosphate precipitates in the environment. Batch dissolution and continuously stirred tank reactor (CSTR) experiments indicate that increasing citrate concentrations from 0.1 mM to 50 mM increases the concentration of dissolved uranium. However, at citrate concentrations of 10 mM and greater, the effectiveness of the ligand to enhance the dissolution decreases. Density functional theory modeling and Raman spectroscopy indicate a strong interaction between citrate and the uranyl ions at the surface of the uranyl phosphate. The interaction between citrate and uranyl suggests the formation of an alteration layer of uranyl-citrate surface complexes, which could impede uranium release at citrate concentrations of 10 mM or higher. Together, these results indicate that the citrate-promoted dissolution of chernikovite is a fast reaction that is hindered by a combination of surface saturation and a secondary-phase precipitation reaction at higher concentrations of citrate and reaction times greater than or equal to 72 minutes based on the hydraulic residence time of CSTR experiments. These findings improve our understanding of the stability of uranyl phosphate for use in sequestration of uranium groundwater plumes at contaminated sites.

The paper examines the role of slum redevelopment in the production of private property in land in a fast-growing city of southern India. Drawing on an in-depth case study in Bengaluru, we show that the tenurial rights of slum residents were eroded when the contested land on which they lived – which was layered with multiple rights and claims of various actors – was confirmed by the court as the sole property of an individual who claimed to be its owner. The transformation of the plot into private property and therefore into a fungible asset, free of encumbrances, allowed the landowner, the political entrepreneurs who spearheaded the redevelopment project, and various intermediaries to capture most of the rapidly escalating value of the land. The exchange of recognized land tenure rights for small flats carrying conditional titles further excluded slum residents from ‘proper’ urban citizenship based on property ownership and exacerbated the precarity of their lives in the city. In this case, in-situ (on the same site) slum redevelopment is shown to operate as a modality of enclosure in which the urban poor are displaced even while remaining in place – or a process of dispossession without displacement.

The relative natural abundance of potassium and potentially high energy density has established potassium-ion batteries as a promising technology for future large-scale global energy storage. However, the anodes’ low capacity and high discharge platform lead to low energy density, which impedes their rapid development. Herein, we present a possible co-activation mechanism between bismuth (Bi) and tin (Sn) that enhanced K-ion storage in battery anodes. The co-activated Bi-Sn anode delivered a high capacity of 634 mAh g–1 with a discharge plateau as low as 0.35 V and operated continuously for 500 cycles at a current density of 50 mA g–1 with high Coulombic efficiency of 99.2%. This possible co-activation strategy for high potassium storage may be extended to other Na/Zn/Ca/Mg/Al ion battery technologies, thus providing insights for improving their energy storage ability.

Scientometrics and bibliometrics, the subfields of library and information science, deal with the quantity and quality of research outputs. Currently, various scientometric indices are being used to quantify and compare research outputs. The most widely known is the h-index. However, this index and its derivatives suffer from dependence on the mere count of a scholar's highly cited publications. To remedy this deficiency, we developed a novel index, the Universal Research Index (UR-Index) (https://usern2021.github.io/UR-Index/) by which every single publication has its own impact on the total score. We developed this index by surveying international top 1 % cited scientists in various disciplines and included additional component variables such as publication type, leading role of a scholar, co-author count, and source metrics to this scientometric index. We acknowledge that unconscious biases built into the component variables included in the UR-Index might put research from specific groups at a disadvantage, thus continued efforts to improve equitable scholarly impact in science and academia are encouraged.

Background: Early and accurate diagnosis of acute infection has important consequences for antibiotic stewardship, resource allocation, and clinical outcomes. However, limited sensitivity and specificity of current diagnostics lead to the erroneous prescription of antibiotics. Host-response-based diagnostics have the potential to address these challenges, but accuracy varies widely across heterogeneous global patient populations. Methods: We performed a multi-cohort analysis of 4,200 unique samples across 69 retrospective blood transcriptome datasets from 20 countries. These samples were collected from patients with acute bacterial or viral infections representing a broad spectrum of biological (age, sex, race, ethnicity, pathogen, host genetics), clinical (severity, day of presentation), and technical (Affymetrix, Agilent, Illumina) heterogeneity. We also enrolled patients with infectious diseases in two cohorts from Laos and Nepal. Findings: Current host-response-based gene signatures distinguished intracellular bacterial infection from viral infections with substantially lower accuracy. Using 69 datasets, divided into training and validation datasets, we identified an 8-gene signature that distinguished intracellular or extracellular bacterial infections from viral infections with an area under the receiver operating characteristic curve (AUROC) >0.91 (85.9% specificity, 90.2% sensitivity). In two prospective cohorts from Nepal and Laos, profiled using Fluidigm RT-PCR, the 8-gene classifier distinguished bacterial infections from viral infections with an AUROC of 0.94 (87.9% specificity, 91% sensitivity). Interpretation: The 8-gene signature met the target product profile (90% sensitivity, 80% specificity) proposed by the WHO and others for distinguishing bacterial and viral infections. The 8-gene signature should be considered for further validation and implementation. Funding Information: PK is funded in part by the Bill and Melinda Gates Foundation (OPP1113682); the National Institute of Allergy and Infectious Diseases (NIAID) grants 1U19AI109662, U19AI057229, and 5R01AI125197; Department of Defense contracts W81XWH-18-1-0253 and W81XWH1910235; and the Ralph & Marian Falk Medical Research Trust. DAR is supported by NIH/NIAID U19 AI109761 and the Thomas C. and Joan M. Merigan Endowment at Stanford University. LOMWRU is funded by the Wellcome Trust of Great Britain. AMR is funded by the National Science Foundation Graduate Research Fellowship and the Stanford Graduate Fellowship. This research was funded in whole, or in part, by the Wellcome Trust [Grant number 220211]. Declaration of Interests: AMR, SJP, TES, DAR, and PK are named as inventors on a patent application describing the 8-gene set, which has been licensed to Inflammatix. TES and SAT are employees of Inflammatix, and TES and PK are shareholders in Inflammatix. Inflammatix had no role in the design, funding, or reporting of this work. SD is currently employed by FIND. The other authors declare no conflicts of interest. Ethics Approval Statement: Ethical clearance was granted by the former Faculty of Medical Sciences Ethical Review Committee (now University of Health Sciences Ethics Committee), National University of Laos, the Oxford University Tropical Ethics Committee, and the Stanford University Institutional Review Board.

We present analyses of an Intermediate Polar, IGR J15094-6649, based on the archival optical data obtained from the Transiting Exoplanet Survey Satellite (TESS) and X-ray data obtained from the Suzaku, NuSTAR, and Neil Gehrels Swift Observatory (Swift). Present analysis confirms and refines the previously reported spin period of IGR J15094-6649 as 809.49584$\pm$0.00075 s. Clear evidence of a beat period of 841.67376$\pm$0.00082 s is found during the long-term TESS optical observations, which was not evident in the earlier studies. The dominance of X-ray and optical spin pulse unveils the disc-fed dominance accretion, however, the presence of an additional beat frequency indicates that part of the accreting material also flows along the magnetic field lines. The energy-dependent spin pulsations in the low (< 10 keV) energy band are due to the photoelectric absorption in the accretion flow. However, the complex absorbers may be responsible to produce low amplitude spin modulations via Compton scattering in the hard ( > 10 keV) energy band and indicate that the height of the X-ray emitting region may be negligible. The observed double-humped X-ray profiles with a pronounced dip are indicative of the photoelectric absorption in the intervening accretion stream. Analysis of the X-ray spectra reveals the complexity of the X-ray emission, being composed of multi-temperature plasma components with a soft excess, reflection, and suffers from strong absorption., 15 pages, 10 figures, and 5 Tables, Accepted for publication in MNRAS. arXiv admin note: text overlap with arXiv:2112.06270

We present our analysis of new and archived observations of two candidate magnetic cataclysmic variables, namely 1RXS J174320.1-042953 and YY Sex. 1RXS J174320.1-042953 was observed in two distinctive high and low states where a phase shift was seen, which could be due to the changes in the shape, size, and (or) location of the accretion region. We find that its orbital X-ray modulations only persist in the soft (0.3-2.0 keV) energy band, which could be attributed to the photoelectric absorption in the accretion flow. The X-ray spectra exhibit a multi-temperature post-shock region where the hard X-rays are absorbed through a thick absorber with an equivalent hydrogen column of $\sim$7.5 $\times$ 10$^{23}$ cm$^{-2}$, which partially covers $\sim$56 per cent of the emission. No soft X-ray excess was found to be present; however, a soft X-ray emission with a blackbody temperature of $\sim$97 eV describes the spectra. Extensive TESS observations of YY Sex allow us to refine its orbital period to 1.5746 $\pm$ 0.0011 h. We did not find any signature of previously reported spin or beat periods in this system. Furthermore, our new polarimetric observations show clear circular polarization modulated on the orbital period only. Finally, both systems show strong Balmer and He II 4686 A$^\circ$ emission lines in the optical spectra, further indicative of their magnetic nature., 16 pages, 12 figures, and 7 tables (accepted for publication in MNRAS)

Phosphorus (P) is one of the essential macronutrients for plant growth and development, and it is an integral part of the major organic components, including nucleic acids, proteins and phospholipids. Although total P is abundant in most soils, a large amount of P is not easily absorbed by plants. Inorganic phosphate (Pi) is the plant-available P, which is generally immobile and of low availability in soils. Hence, Pi starvation is a major constraint limiting plant growth and productivity. Enhancing plant P efficiency can be achieved by improving P acquisition efficiency (PAE) through modification of morpho-physiological and biochemical alteration in root traits that enable greater acquisition of external Pi from soils. Major advances have been made to dissect the mechanisms underlying plant adaptation to P deficiency, especially for legumes, which are considered important dietary sources for humans and livestock. This review aims to describe how legume root growth responds to Pi starvation, such as changes in the growth of primary root, lateral roots, root hairs and cluster roots. In particular, it summarizes the various strategies of legumes to confront P deficiency by regulating root traits that contribute towards improving PAE. Within these complex responses, a large number of Pi starvation-induced (PSI) genes and regulators involved in the developmental and biochemical alteration of root traits are highlighted. The involvement of key functional genes and regulators in remodeling root traits provides new opportunities for developing legume varieties with maximum PAE needed for regenerative agriculture.