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Artificial intelligence is widely used in everyday life. However, an insufficient computing efficiency due to the so-called von Neumann bottleneck cannot satisfy the demand for real-time processing of rapidly growing data. Memristive in-memory computing is a promising candidate for highly efficient data processing. However, performance of memristors varies significantly because of microstructure change induced by electric-driven matter migration. Here, we propose an all-optically controlled (AOC) memristor with a simple Au/ZnO/Pt sandwich structure based on a purely electronic tuning mechanism of memconductance. The memconductance can be reversibly tuned only by light irradiation with different wavelengths. The device can be used to perform in-memory computation such as nonvolatile neuromorphic computing and Boolean logic functions. Moreover, no microstructure change is involved during the operation of our AOC memristor which demonstrates superior operation stability. Based on this and its structural simplicity, the device has attractive application prospects for the next generation of computing systems., 44 pages, 19 figures

The emergence of drug-resistant tumour cells significantly interferes with the effectiveness of chemotherapeutic treatment plans and represents a major obstacle in the ongoing quest to overcome cancers. Therefore, exploring in detail new therapeutic strategies that can obviate this important challenge is regarded as a very important topic at the time being. Herein, we propose a non-invasive and remotely controllable mechano-chemotherapeutic approach that relies on the use of a rotating magnetic field (RMF) of low intensity (45 m T) in combination with a therapeutic agent consisting of a composite nanomaterial comprised of a poly(lactic-co-glycolic acid) (PLGA) shell co-loaded with Zn0.2Fe2.8O4 magnetic nanoparticles (mNPs) and Doxorubicin (DOX). We show that RMF exposure induces a mechanical movement to this nanomaterial, which can be exploited for (i) controllably releasing the anti-cancer drug for chemotherapy, and (ii) promoting the death of tumour cells by means of mechanical forces exerted onto their membranes. Such dual behavior leads to combating cancer cells via different and complementary routes enabling a controllable and efficient therapy. The proposed model enables controllable tumor therapy by precisely operating the magnetic nanomaterials at the nanometer scale, and its applicability is neither restricted to the nanomaterial here demonstrated nor to solely addressing cancer. Modified variants of the proposed model, together with the corresponding therapeutic agents, can be developed to address other pathologies, enabling novel therapeutic approaches that exceed the precision and efficiency of current ones.