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Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance
- Source :
- Nano Today. 35:100967
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The emergence of drug-resistant tumour cells significantly interferes with the effectiveness of chemotherapeutic treatment plans and represents a major obstacle in the ongoing quest to overcome cancers. Therefore, exploring in detail new therapeutic strategies that can obviate this important challenge is regarded as a very important topic at the time being. Herein, we propose a non-invasive and remotely controllable mechano-chemotherapeutic approach that relies on the use of a rotating magnetic field (RMF) of low intensity (45 m T) in combination with a therapeutic agent consisting of a composite nanomaterial comprised of a poly(lactic-co-glycolic acid) (PLGA) shell co-loaded with Zn0.2Fe2.8O4 magnetic nanoparticles (mNPs) and Doxorubicin (DOX). We show that RMF exposure induces a mechanical movement to this nanomaterial, which can be exploited for (i) controllably releasing the anti-cancer drug for chemotherapy, and (ii) promoting the death of tumour cells by means of mechanical forces exerted onto their membranes. Such dual behavior leads to combating cancer cells via different and complementary routes enabling a controllable and efficient therapy. The proposed model enables controllable tumor therapy by precisely operating the magnetic nanomaterials at the nanometer scale, and its applicability is neither restricted to the nanomaterial here demonstrated nor to solely addressing cancer. Modified variants of the proposed model, together with the corresponding therapeutic agents, can be developed to address other pathologies, enabling novel therapeutic approaches that exceed the precision and efficiency of current ones.
- Subjects :
- Chemotherapy
Materials science
medicine.medical_treatment
Biomedical Engineering
Pharmaceutical Science
Tumor therapy
Bioengineering
Nanotechnology
02 engineering and technology
Drug resistance
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
PLGA
chemistry.chemical_compound
chemistry
Cancer cell
medicine
Magnetic nanoparticles
General Materials Science
Doxorubicin
0210 nano-technology
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 17480132
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Nano Today
- Accession number :
- edsair.doi...........e6cde0c4b2266799b0f211a3af7c0b1c