1. Measured parental height in Turner syndrome—a valuable but underused diagnostic tool
- Author
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Malcolm Donaldson, Avril Mason, Chourouk Mansour, Filiz Mine Çizmecioğlu, Emma Jane Gault, Jeremy Jones, and Yasmine Ouarezki
- Subjects
Parents ,medicine.medical_specialty ,Adolescent ,Turner syndrome ,Karyotype ,Growth promotion ,030209 endocrinology & metabolism ,Target range ,Short stature ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,Sensitivity ,030225 pediatrics ,Lower end of parental target range ,medicine ,Prevalence ,Birth Weight ,Humans ,Child ,Retrospective Studies ,Gynecology ,business.industry ,Infant, Newborn ,Mid-parental height ,Infant ,medicine.disease ,Body Height ,Child, Preschool ,Karyotyping ,Pediatrics, Perinatology and Child Health ,Specificity ,Female ,Original Article ,medicine.symptom ,Parental height ,business - Abstract
Early diagnosis of Turner syndrome (TS) is necessary to facilitate appropriate management, including growth promotion. Not all girls with TS have overt short stature, and comparison with parental height (Ht) is needed for appropriate evaluation. We examined both the prevalence and diagnostic sensitivity of measured parental Ht in a dedicated TS clinic between 1989 and 2013. Lower end of parental target range (LTR) was calculated as mid-parental Ht (correction factor 12.5 cm minus 8.5 cm) and converted to standard deviation scores (SDS) using UK 1990 data, then compared with patient Ht SDS at first accurate measurement aged > 1 year. Information was available in 172 girls of whom 142 (82.6%) were short at first measurement. However, both parents had been measured in only 94 girls (54.6%). In 92 of these girls age at measurement was 6.93 ± 3.9 years, Ht SDS vs LTR SDS − 2.63 ± 0.94 vs − 1.77 ± 0.81 (p
- Published
- 2018